LGALS3

This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. The protein exhibits antimicrobial activity against bacteria and fungi. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

Description

Galectin 3

Tissue specificity

Tissue enhanced (intestine)

Subcell location

Nucleoplasm, Plasma membrane, Cytosol

Predicted location

Intracellular, Secreted to blood

Protein family

Cancer-related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

14:q22.3 (55124110 - 55145423)

Ensembl ID

ENSG00000131981  (ver. 103.38)

Orthologs

Mouse Lgals3: ENSMUSG00000050335

UniProt

P17931

neXtProt

NX_P17931

Human splice variants
Mouse splice variants