LGALS3

This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. The protein exhibits antimicrobial activity against bacteria and fungi. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

Description

lectin, galactoside-binding, soluble, 3

Protein family

Cancer-related genes, Mapped to UniProt SWISS-PROT, Plasma proteins, Predicted intracellular proteins, Protein evidence (Ezkurdia et al 2014), Protein evidence (Kim et al 2014)

Chromosome

14:q22.3 (55124110 - 55145413)

Ensembl ID

ENSG00000131981  (ver. 84.38)

Orthologs

Mouse Lgals3: ENSMUSG00000050335

UniProt

P17931

neXtProt

NX_P17931

Human splice variants
Mouse splice variants