60207-1-Ig

antibody from Proteintech Group

Targeting: LGALS3 GALIG, LGALS2, MAC-2

Provider product page for 60207-1-Ig

Western blot

ELISA

Immunocytochemistry

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [68]
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Validations
Western blot [1]
Immunocytochemistry [1]
Immunohistochemistry [2]

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Product number: 60207-1-Ig - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#60207-1-Ig, RRID:AB_10951109
Product name: Galectin-3 antibody
Antibody type: Monoclonal
Description: KD/KO validated Galectin-3 antibody (Cat. #60207-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Antibody clone number: 1C1B2
Vial size: 20ul, 150ul

LGALS3 protein structure - 60207-1-Ig shown in red.

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The FEBS journal 2026 Mar 30;

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Wang S, Han W, Zhao B, Hong Y, Li J, Miao J, Lin Z
PLoS pathogens 2026 Feb;22(2):e1013932

A Biomimetic Mn-Doped Polydopamine Nanoplatform for MRI-Enabled Synergistic Therapy to Enhance Lenvatinib Efficacy in Liver Cancer.

Luo W, Ma Y, Zhu W, Nie R, Wu Y, Shan D, Xu S, Song HY, Hu H
ACS applied materials & interfaces 2026 Apr 29;18(16):22769-22783

tRF-AspGTC Promotes Intracranial Aneurysm Formation by Controlling TRIM29-Mediated Galectin-3 Ubiquitination.

Wang C, Yu B, Zhou H, Li H, Li S, Li X, Wang W, Feng Y, Yu T
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Zheng Z, Chen J, Xue X, Ma X, Zhang S, Wang M, Xue Y, Jia Y
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Xu G, Chen H, Cong Z, Zhou L, Zhao N, Yang Y, Li T, Liu X, Wang Y, Li B
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Du C, Ma C, Geng R, Wang X, Wang X, Yang J, Hu J
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Huang J, Weng Y, Feng Y, Wu D, Chen Y, Li Z, Jiang X, Wang H, Wang Z
Nature communications 2025 Aug 14;16(1):7543

VCP Inhibition Augments NLRP3 Inflammasome Activation.

Sharma A, Dhavale DD, Kotzbauer PT, Weihl CC
Inflammation 2024 Oct;47(5):1868-1883

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Xing Y, Yang J, Peng A, Qian Y, Liu Y, Pan P, Liu Q
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Fu M, Zhao J, Zhang L, Sheng Z, Li X, Qiu F, Feng Y, You M, Xu H, Zhang J, Zeng R, Huang Y, Li C, Chen W, Chen Z, Peng H, Li L, Wu Y, Ye D, Chi Y, Hua W, Mao Y
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Goto E, Taki T, Nomura K, Miyakami Y, Miyoshi T, Tane K, Samejima J, Aokage K, Nagamine M, Sakashita S, Sakamoto N, Kojima M, Suzuki K, Tsuboi M, Ishii G
Lung cancer (Amsterdam, Netherlands) 2024 Jun;192:107830

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TFEB ameliorates DEHP-induced neurotoxicity by activating GAL3/TRIM16 axis dependent lysophagy and alleviating lysosomal dysfunction.

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Environmental toxicology 2024 Jul;39(7):3779-3789

Surplus fatty acid synthesis increases oxidative stress in adipocytes and lnduces lipodystrophy.

Weng L, Tang WS, Wang X, Gong Y, Liu C, Hong NN, Tao Y, Li KZ, Liu SN, Jiang W, Li Y, Yao K, Chen L, Huang H, Zhao YZ, Hu ZP, Lu Y, Ye H, Du X, Zhou H, Li P, Zhao TJ
Nature communications 2024 Jan 2;15(1):133

Y9, a Gboxin analog, displays anti-tumor effect in non-small cell lung cancer by inducing lysosomal dysfunction and apoptosis.

Yin J, Ding L, Yao S, Huang J, Xiao Y, Wang Y, Zhang B, Rehmutulla M, Gu L, Tong Q, Zhang Y
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Zinc ions regulate mitochondrial quality control in neurons under oxidative stress and reduce PANoptosis in spinal cord injury models via the Lgals3-Bax pathway.

Bai M, Cui Y, Sang Z, Gao S, Zhao H, Mei X
Free radical biology & medicine 2024 Aug 20;221:169-180

IFI-16 inhibition attenuates myocardial remodeling following myocardial infarction.

Deng Y, Pang X, Chen L, Peng W, Huang X, Huang P, Zhao S, Li Z, Cai X, Huang Q, Zeng J, Feng Y, Chen B
iScience 2024 Aug 16;27(8):110568

Lysosomal destabilization: A missing link between pathological calcification and osteoarthritis.

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SMURF1 controls the PPP3/calcineurin complex and TFEB at a regulatory node for lysosomal biogenesis.

Xia Q, Zheng H, Li Y, Xu W, Wu C, Xu J, Li S, Zhang L, Dong L
Autophagy 2024 Apr;20(4):735-751

Chemical Carcinogen (Dimethyl-benzanthracene) Induced Transplantable Cancer in Fanconi Anemia (Fanca-/-) Mice.

Epperly MW, Mukherjee A, Fisher R, Shields D, Hou W, Wang H, Rigatti LH, Green A, Huq MS, Greenberger JS
In vivo (Athens, Greece) 2023 Nov-Dec;37(6):2421-2432

Transmission of NLRP3-IL-1β Signals in Cerebral Ischemia and Reperfusion Injury: from Microglia to Adjacent Neuron and Endothelial Cells via IL-1β/IL-1R1/TRAF6.

Pan J, Peng J, Li X, Wang H, Rong X, Peng Y
Molecular neurobiology 2023 May;60(5):2749-2766

Choline-deficient Diet-induced NAFLD Animal Model Recaptures Core Human Pathophysiology With Similar Gene Co-expression Networks.

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In vivo (Athens, Greece) 2023 Jul-Aug;37(4):1517-1531

Mechano-dependent sorbitol accumulation supports biomolecular condensate.

Torrino S, Oldham WM, Tejedor AR, Burgos IS, Rachedi N, Fraissard K, Chauvet C, Sbai C, O'Hara BP, Abélanet S, Brau F, Clavel S, Collepardo-Guevara R, Espinosa JR, Ben-Sahra I, Bertero T
bioRxiv : the preprint server for biology 2023 Jul 25;

Involvement of Galectin-3 in neurocognitive impairment in obstructive sleep apnea via regulating inflammation and oxidative stress through NLRP3.

Zong D, Liu X, Shen C, Liu T, Ouyang R
Sleep medicine 2023 Jan;101:1-10

Leucine-rich repeat kinase 2 (LRRK2) inhibition upregulates microtubule-associated protein 1B to ameliorate lysosomal dysfunction and parkinsonism.

Chen K, Tang F, Du B, Yue ZZ, Jiao LL, Ding XL, Tuo QZ, Meng J, He SY, Dai L, Lei P, Wei XW
MedComm 2023 Dec;4(6):e429

Catalpol Prevents Glomerular Angiogenesis Induced by Advanced Glycation End Products via Inhibiting Galectin-3.

Sun WX, Gao YY, Cao Y, Lu JF, Lv GH, Xu HQ
Current medical science 2023 Aug;43(4):668-678

Hepatocyte-derived MASP1-enriched small extracellular vesicles activate HSCs to promote liver fibrosis.

Liu X, Tan S, Liu H, Jiang J, Wang X, Li L, Wu B
Hepatology (Baltimore, Md.) 2023 Apr 1;77(4):1181-1197

Modified Citrus Pectin Alleviates Cerebral Ischemia/Reperfusion Injury by Inhibiting NLRP3 Inflammasome Activation via TLR4/NF-ĸB Signaling Pathway in Microglia.

Cui Y, Zhang NN, Wang D, Meng WH, Chen HS
Journal of inflammation research 2022;15:3369-3385

Single-cell RNA sequencing reveals a novel inhibitory effect of ApoA4 on NAFL mediated by liver-specific subsets of myeloid cells.

Liu XH, Zhou JT, Yan CX, Cheng C, Fan JN, Xu J, Zheng Q, Bai Q, Li Z, Li S, Li X
Frontiers in immunology 2022;13:1038401

Transcriptomic Analysis Reveals that Activating Transcription Factor 3/c-Jun/Lgals3 Axis Is Associated with Central Diabetes Insipidus after Hypothalamic Injury.

Zhou M, Ou Y, Wu G, Li K, Peng J, Wang X, Che M, Gong H, Niu P, Liu Y, Feng Z, Qi S
Neuroendocrinology 2022;112(9):874-893

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Hong CL, Yu IS, Pai CH, Chen JS, Hsieh MS, Wu HL, Lin SW, Huang HP
Cancer research 2022 Oct 17;82(20):3734-3750

Galectin-3 Is a Natural Binding Ligand of MCAM (CD146, MUC18) in Melanoma Cells and Their Interaction Promotes Melanoma Progression.

Pang Y, Maxwell E, Sindrewicz-Goral P, Shapanis A, Li S, Morgan M, Yu LG
Biomolecules 2022 Oct 10;12(10)

Thiamine pretreatment improves endotoxemia-related liver injury and cholestatic complications by regulating galactose metabolism and inhibiting macrophage activation.

Li T, Bai J, Du Y, Tan P, Zheng T, Chen Y, Cheng Y, Cai T, Huang M, Fu W, Wen J
International immunopharmacology 2022 Jul;108:108892

17β-Estradiol Attenuates LPS-Induced Macrophage Inflammation In Vitro and Sepsis-Induced Vascular Inflammation In Vivo by Upregulating miR-29a-5p Expression.

Zhang ML, Chen H, Yang Z, Zhang MN, Wang X, Zhao K, Li X, Xiu N, Tong F, Wang YX
Mediators of inflammation 2021;2021:9921897

Quantitative proteomics reveals the selectivity of ubiquitin-binding autophagy receptors in the turnover of damaged lysosomes by lysophagy.

Eapen VV, Swarup S, Hoyer MJ, Paulo JA, Harper JW
eLife 2021 Sep 29;10

Galectin‑3 facilitates the proliferation and migration of nasopharyngeal carcinoma cells via activation of the ERK1/2 and Akt signaling pathways, and is positively correlated with the inflammatory state of nasopharyngeal carcinoma.

Li M, Chen YB, Liu F, Qu JQ, Ren LC, Chai J, Tang CE
Molecular medicine reports 2021 May;23(5)

Tumor cell membrane-based peptide delivery system targeting the tumor microenvironment for cancer immunotherapy and diagnosis.

Meng X, Wang J, Zhou J, Tian Q, Qie B, Zhou G, Duan W, Zhu Y
Acta biomaterialia 2021 Jun;127:266-275

Pro64His (rs4644) Polymorphism Within Galectin-3 Is a Risk Factor of Differentiated Thyroid Carcinoma and Affects the Transcriptome of Thyrocytes Engineered via CRISPR/Cas9 System.

Corrado A, Aceto R, Silvestri R, Dell'Anno I, Ricci B, Miglietta S, Romei C, Giovannoni R, Poliseno L, Evangelista M, Vitiello M, Cipollini M, Garritano S, Giusti L, Zallocco L, Elisei R, Landi S, Gemignani F
Thyroid : official journal of the American Thyroid Association 2021 Jul;31(7):1056-1066

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HeLa cells were subjected to SDS PAGE followed by western blot with 60207-1-Ig(Galectin 3 antibody) at dilution of 1:1000
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of MCF-7 cells, using LGALS3 antibody 60207-1-lg at 1:50 dilution and Rhodamine-labeled goat anti-mouse IgG (red).
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human colon using 60207-1-Ig(Galectin 3 antibody) at dilution of 1:200 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human colon using 60207-1-Ig(Galectin 3 antibody) at dilution of 1:200 (under 40x lens)
Sample type: tissue