Antibody data
- Antibody Data
- Antigen structure
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- Comments [0]
- Validations
- Flow cytometry [1]
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- Product number
- 126706 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#126706, RRID:AB_1134012
- Product name
- PE anti-mouse/human Mac-2 (Galectin-3)
- Antibody type
- Monoclonal
- Antigen
- Recombinant (partial) human Galectin-3
- Description
- Galectin-3 (galactose-specific lectin 3) is a 30-32 kD glycoprotein, also known as Mac-2, Gal-3, RL-29, galactose-specific lectin 3, CBP-35, L-34, and εBP. It is a member of the animal β-galactoside-binding lectin family that is expressed in the cell nucleus, cytoplasm, plasma membrane, or extracellular matrix by variety of tumor cells, monocytes/macrophages, epithelial cells, Kupffer cells, and dendritic cells. Galectin-3 contains carbohydrate recognition domains and binds to β-galactoside residues bearing glycoproteins, such as as IgE, IgA, galactose, casein kinase I, laminin, mucin, LAMPs, and CD66. Galectin-3 is an adhesion molecule and plays an important role in regulation of cell proliferation, differentiation and tumor cell metastasis. Structurally, Galectin-3 possesses NWGR motif that is conserved in the BH-1 domain of the BCL-2 family and functions as an anti-apoptotic molecule.
- Reactivity
- Human, Mouse
- Host
- Mouse
- Conjugate
- Yellow dye
- Isotype
- IgG
- Vial size
- 200 µg
- Concentration
- 0.2 mg/ml
- Storage
- The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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Supportive validation
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- BioLegend (provider)
- Main image
- Experimental details
- Human peripheral blood monocytes intracellular stained with Gal397 PE
- Conjugate
- Yellow dye