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- Antigen structure
- References [6]
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- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 12305-2-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12305-2-AP, RRID:AB_2056369
- Product name
- APLP1 antibody
- Antibody type
- Polyclonal
- Description
- APLP1 antibody (Cat. #12305-2-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Familial Alzheimer's disease mutations in amyloid precursor protein impair calcineurin signaling to NMDA receptors.
APLP1 Interacts with SARM1 and Regulates Axonal Maintenance and Post-Injury Degeneration.
Tau and other proteins found in Alzheimer's disease spinal fluid are linked to retromer-mediated endosomal traffic in mice and humans.
Label-free Quantitative Proteomics of Mouse Cerebrospinal Fluid Detects β-Site APP Cleaving Enzyme (BACE1) Protease Substrates In Vivo.
Label-Free LC-MS/MS Proteomic Analysis of Cerebrospinal Fluid Identifies Protein/Pathway Alterations and Candidate Biomarkers for Amyotrophic Lateral Sclerosis.
Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons.
Tavalin SJ
The Journal of biological chemistry 2025 Feb;301(2):108147
The Journal of biological chemistry 2025 Feb;301(2):108147
APLP1 Interacts with SARM1 and Regulates Axonal Maintenance and Post-Injury Degeneration.
Kang M, Kim H, Jeon Y, Shin YK, Park HT, Shin JE
Molecular neurobiology 2025 Dec 1;63(1):225
Molecular neurobiology 2025 Dec 1;63(1):225
Tau and other proteins found in Alzheimer's disease spinal fluid are linked to retromer-mediated endosomal traffic in mice and humans.
Simoes S, Neufeld JL, Triana-Baltzer G, Moughadam S, Chen EI, Kothiya M, Qureshi YH, Patel V, Honig LS, Kolb H, Small SA
Science translational medicine 2020 Nov 25;12(571)
Science translational medicine 2020 Nov 25;12(571)
Label-free Quantitative Proteomics of Mouse Cerebrospinal Fluid Detects β-Site APP Cleaving Enzyme (BACE1) Protease Substrates In Vivo.
Dislich B, Wohlrab F, Bachhuber T, Müller SA, Kuhn PH, Hogl S, Meyer-Luehmann M, Lichtenthaler SF
Molecular & cellular proteomics : MCP 2015 Oct;14(10):2550-63
Molecular & cellular proteomics : MCP 2015 Oct;14(10):2550-63
Label-Free LC-MS/MS Proteomic Analysis of Cerebrospinal Fluid Identifies Protein/Pathway Alterations and Candidate Biomarkers for Amyotrophic Lateral Sclerosis.
Collins MA, An J, Hood BL, Conrads TP, Bowser RP
Journal of proteome research 2015 Nov 6;14(11):4486-501
Journal of proteome research 2015 Nov 6;14(11):4486-501
Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons.
Kuhn PH, Koroniak K, Hogl S, Colombo A, Zeitschel U, Willem M, Volbracht C, Schepers U, Imhof A, Hoffmeister A, Haass C, Roßner S, Bräse S, Lichtenthaler SF
The EMBO journal 2012 Jun 22;31(14):3157-68
The EMBO journal 2012 Jun 22;31(14):3157-68
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse brain tissue were subjected to SDS PAGE followed by western blot with 12305-2-AP( APLP1 Antibody) at dilution of 1:1000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The APLP1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human APLP1. This antibody recognizes human, mouse antigen. The APLP1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
