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- References [164]
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- Product number
- 23673-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- UCP1 antibody
- Antibody type
- Polyclonal
- Description
- UCP1 antibody (Cat. #23673-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Puerarin Improves Glucose and Lipid Metabolism in Type 2 Diabetes by Regulating Gut Microbiota Homeostasis and Promoting Adipose Tissue Thermogenesis.
Exosomal miR-1246 of adipose stem cells attenuates obesity by polarizing M2 macrophages, reducing fat mass, and beiging of white adipose tissue.
PTG-Dependent Glycogen Metabolic Dysfunction Drives Impaired Adipose Browning: A Novel Mechanism Linking PM(2.5) to Metabolic Disorders.
Dendrobium officinale polysaccharide ameliorate hyperlipidemia through LKB1/AMPK and CD36/PGC-1α/UCP1 activation and gut microbiota modulation.
Metabolic beneficial effects of targeting a long non-coding RNA, lnc-megacluster, in obesity.
Growth hormone enhances mitochondria biogenesis and endows mitochondrial thermogenesis in murine adipocytes.
Flavonoid-rich extracts of Nelumbo nucifera leaves alleviate obesity in HFD-fed mice via microbiota-dependent modulation of brown fat thermogenesis.
Exclusive Breastfeeding Drives AMPK-Dependent Thermogenic Memory in BAT and Promotes Long-Term Metabolic Benefits in Offspring.
WTAP Maintains Alternative Activation of Macrophages by Promoting IDH1-Mediated α-ketoglutarate Production.
Human milk-derived 5'-UMP promotes thermogenesis and mitochondrial biogenesis to ameliorate obesity.
Targeting Dlat-Trpv3 pathway by hyperforin elicits non-canonical promotion of adipose thermogenesis as an effective anti-obesity strategy.
Gut microbiota modified by Mulberry leaf water extract improves T2DM through browning of WAT/BAT activation mediated by SCFAs-AMPK/SIRT1/PGC-1α signaling pathway.
Bisphenol A increases fat mass in adipose tissue by disturbing gut microbiota-dependent bile acid metabolism and TGR5/UCP1 signaling pathways in CD-1 mice.
Downregulation of uncoupling protein 1 by hypermethylation in gastric cancer activates Rap1 signaling.
Phosphatidylethanolamine/PKA signal axis mediated human milk extracellular vesicles enhance adipose thermogenesis and lipolysis via mitochondrial remodeling.
A Novel Glucomannan from Dendrobium officinale Inhibits Obesity and Improves Insulin Sensitivity through Regulating Adipogenesis and Lipid Metabolism.
Gut symbiont-derived ursodeoxycholic acid promotes fatty acid oxidation to protect against renal ischemia-reperfusion injury.
Cetacean loss of the master adipose tissue regulator β(3)-adrenergic receptor may underlie their thick blubber and an Oligocene radiation and dispersal.
Loss of histone methyltransferase Smyd3 triggers WAT browning and adaptive thermogenesis via enhancing PPARγ expression in a H4K20me3-dependent manner.
Eurotium Cristatum fermented instant dark tea prevents obesity and promotes adipose thermogenesis via modulating the gut microbiota.
Quercetin ameliorates renal injury by promoting UCP1-mediated alleviation of lipid accumulation in diabetic kidney disease.
Avian GCGR-mediated continuous fat utilization offers perspectives for obesity treatment.
Structural characterization and alleviative effects of novel polysaccharides from Artemisia sphaerocephala Krasch seed on obese mice by regulating gut microbiota.
Etomoxir suppresses the expression of PPARγ2 and inhibits the thermogenic gene induction of brown adipocytes through pathways other than β-oxidation inhibition.
The clinical antiprotozoal drug halofuginone promotes weight loss by elevating GDF15 and FGF21.
Brown adipose tissue transplantation ameliorates hindlimb ischemic damage in diabetic mice.
Barley polysaccharides modulate metabolic and mild cognitive impairment in naturally aging mice through the liver-gut-brain axis.
Time-restricted feeding mitigates HFD-induced sarcopenic obesity in aging mice through improving the sensitivity of FGF21.
Brown adipose tissue secretes OLFM4 to coordinate sensory and sympathetic innervation via Schwann cells.
UCP1 prevents the formation of thoracic aortic aneurysms and dissection by inhibiting the TLR4/NLRP3/IL-1β signaling pathway and VSMC phenotype switching in mice.
Anthraquinones of Cassiae Semen alleviate lipid accumulation in obesity by regulating brown adipose tissue and liver function.
Medium-chain triglyceride attenuates obesity by activating brown adipose tissue via upregulating the AMPK signaling pathway.
Polystyrene microplastics impair brown and beige adipocyte function via the gut microbiota-adipose tissue crosstalk in high-fat diet mice.
Resveratrol stimulates brown of white adipose via regulating ERK/DRP1-mediated mitochondrial fission and improves systemic glucose homeostasis.
Integrating network pharmacology and transcriptomics to study the potential mechanism of Jingzhi Niuhuang Jiedu tablet in rats with accumulation of heat in the lungs and stomach.
Maternal neonicotinoid pesticide exposure impairs glucose metabolism by deteriorating brown fat thermogenesis.
Isoliquiritigenin Ameliorates High-Fat Diet-Induced Obesity in Mice by Activating Brown Adipose Tissue.
MDPAO1 peptide from human milk enhances brown adipose tissue thermogenesis and mitigates obesity.
Baicalin alleviates sepsis-associated acute kidney injury through activation of the PPAR-γ/UCP1 signaling pathway.
Curcumin Inhibits Bisphenol A-Induced Fat Mass Gain by Enhancing White Adipose Tissue Browning via Modulating Gut Microbiota-Dependent Bile Acid Metabolism in CD-1 Mice.
The suprachiasmatic nucleus regulates brown fat thermogenesis in male mice through an adrenergic receptor ADRB3-S100B signaling pathway.
Dietary cannabidiol oil mitigates metabolic dysfunction in mice with high-fat diet-induced obesity.
WDR4-mediate tRNA m7G modification to promote mitophagy and browning of white adipose tissue for ameliorating obesity in male mice.
NRF2-REGγ-ACADM/KLF15 Signaling Pathway Regulates the Browning of White Adipose Tissue to Modulate Obesity.
Blubber Thickening Driven by UCP1 Inactivation: Insights from a Cetacean-Like Transgenic Mouse Model.
Blocking glycogen synthase 1 in white adipose tissue alleviates hypermetabolism following severe burn injury through inhibition of JAK2 by UDPG.
Eurotium cristatum Ameliorates Glucolipid Metabolic Dysfunction of Obese Mice in Association with Regulating Intestinal Gluconeogenesis and Microbiome.
Nrg4 Secreted by Brown Adipose Tissue Suppresses Ferroptosis of Sepsis-Induced Liver Injury.
Combination of Berberine and Evodiamine Alleviates Obesity by Promoting Browning in 3T3-L1 Cells and High-Fat Diet-Induced Mice.
Green Tea Ameliorates Depression-Like Behavior and Cognitive Impairment Induced by High-Fat Diet and Chronic Mild Stress.
Ling-gui-zhu-gan granules reduces obesity and ameliorates metabolic disorders by inducing white adipose tissue browning in obese mice.
TRPC absence induces pro-inflammatory macrophage polarization to promote obesity and exacerbate colorectal cancer.
Ling-gui-zhu-gan promotes adipocytes browning via targeting the miR-27b/PRDM16 pathway in 3T3-L1 cells.
Xiasangju alleviate metabolic syndrome by enhancing noradrenaline biosynthesis and activating brown adipose tissue.
Exercise attenuates high-fat diet-induced PVAT dysfunction through improved inflammatory response and BMP4-regulated adipose tissue browning.
siRNA nanoparticle targeting Usp20 lowers lipid levels and ameliorates metabolic syndrome in mice.
Single-Cell Landscape and a Macrophage Subset Enhancing Brown Adipocyte Function in Diabetes.
Lactating striped hamsters (Cricetulus barabensis) do not decrease the thermogenic capacity to cope with extreme cold temperature.
Synthesis and anti-proliferative effect of novel 4-Aryl-1, 3-Thiazole-TPP conjugates via mitochondrial uncoupling process.
GRP75 triggers white adipose tissue browning to promote cancer-associated cachexia.
Renal denervation alleviates vascular remodeling in spontaneously hypertensive rats by regulating perivascular adipose tissue.
Effective Prevention and Treatment of Acute Leukemias in Mice by Activation of Thermogenic Adipose Tissues.
Effects of the Fungicide Prothioconazole on Lipid Metabolism in Mice: Whitening Alterations of Brown Adipose Tissue.
SGLT2 inhibitor canagliflozin reduces visceral adipose tissue in db/db mice by modulating AMPK/KLF4 signaling and regulating mitochondrial dynamics to induce browning.
Characterization of Ucp1-iCre knockin mice reveals the recombination activity in male germ cells.
Procyanidin B2 improves developmental capacity of bovine oocytes via promoting PPARγ/UCP1-mediated uncoupling lipid catabolism during in vitro maturation.
Sestrin2 in POMC neurons modulates energy balance and obesity related metabolic disorders via mTOR signaling.
Sexual dimorphism in thermogenic regulators and metrnl expression in adipose tissue of offspring mice exposed to maternal and postnatal overnutrition.
Exercise-inducible circulating extracellular vesicle irisin promotes browning and the thermogenic program in white adipose tissue.
Loss of FoxO1 activates an alternate mechanism of mitochondrial quality control for healthy adipose browning.
Global gene expression profiling of perirenal brown adipose tissue whitening in goat kids reveals novel genes linked to adipose remodeling.
Eugenol mimics exercise to promote skeletal muscle fiber remodeling and myokine IL-15 expression by activating TRPV1 channel.
Structural Variances in Curcumin Degradants: Impact on Obesity in Mice.
Ginsenoside Rb1 regulates CPT1A deacetylation to inhibit intramuscular fat infiltration after rotator cuff tear.
Alisol B 23-acetate promotes white adipose tissue browning to mitigate high-fat diet-induced obesity by regulating mTOR-SREBP1 signaling.
MIIP downregulation drives colorectal cancer progression through inducing peri-cancerous adipose tissue browning.
Dysregulation of mitochondrial dynamics mediated aortic perivascular adipose tissue-associated vascular reactivity impairment under excessive fructose intake.
Brown adipose Vanin-1 is required for the maintenance of mitochondrial homeostasis and prevents diet-induced metabolic dysfunction.
miR-1182-mediated ALDH3A2 inhibition affects lipid metabolism and progression in ccRCC by activating the PI3K-AKT pathway.
Whitening of brown adipose tissue inhibits osteogenic differentiation via secretion of S100A8/A9.
Body size influences the capacity to cope with extreme cold or hot temperatures in the striped hamster.
Adipose Tissue-Resident Sphingomonas Paucimobilis Suppresses Adaptive Thermogenesis by Reducing 15-HETE Production and Inhibiting AMPK Pathway.
Sodium Houttuybonate Promotes the Browning of White Adipose Tissue by Inhibiting Ferroptosis via the AMPK-NRF2-HO1 Pathway.
Adipocyte-Targeted Nanocomplex with Synergistic Photothermal and Pharmacological Effects for Combating Obesity and Related Metabolic Syndromes.
Repurposing lansoprazole to alleviate metabolic syndrome via PHOSPHO1 inhibition.
Pterostilbene Enhances Thermogenesis and Mitochondrial Biogenesis by Activating the SIRT1/PGC-1α/SIRT3 Pathway to Prevent Western Diet-Induced Obesity.
Polysaccharide from Ziyang Selenium-Enriched Green Tea Prevents Obesity and Promotes Adipose Thermogenesis via Modulating the Gut Microbiota.
Acetyl-coenzyme A acetyltransferase 1 promotes brown adipogenesis by activating the AMPK-PGC1α signaling pathway.
Geniposide ameliorates atherosclerosis by regulating macrophage polarization via perivascular adipocyte-derived CXCL14.
Miquelianin in Folium Nelumbinis extract promotes white-to-beige fat conversion via blocking AMPK/DRP1/mitophagy and modulating gut microbiota in HFD-fed mice.
HDAC1 inhibits beige adipocyte-mediated thermogenesis through histone crotonylation of Pgc1a/Ucp1.
CX3CR1(hi) macrophages sustain metabolic adaptation by relieving adipose-derived stem cell senescence in visceral adipose tissue.
Metrnl Alleviates Lipid Accumulation by Modulating Mitochondrial Homeostasis in Diabetic Nephropathy.
Bioactivity-based molecular networking-guided identification of guttiferone J from Garcinia cambogia as an anti-obesity candidate.
Adipocyte YTH N(6)-methyladenosine RNA-binding protein 1 protects against obesity by promoting white adipose tissue beiging in male mice.
FoxO1 regulates adipose transdifferentiation and iron influx by mediating Tgfβ1 signaling pathway.
Hypoxia promotes white adipose tissues browning in rats under simulated environment at altitude of 5000 m.
T-cell immunoglobulin- and mucin-domain-containing molecule-4 maintains adipose tissue homeostasis by orchestrating M2 macrophage polarization via nuclear factor kappa B pathway.
Knockout of ICAT in Adipose Tissue Alleviates Fibro-inflammation in Obese Mice.
Increased BAT Thermogenesis in Male Mouse Apolipoprotein A4 Transgenic Mice.
Lipopolysaccharide-induced persistent inflammation ameliorates fat accumulation by promoting adipose browning in vitro and in vivo.
CCE and EODF as two distinct non-shivering thermogenesis models inducing weight loss.
Muscle-specific ER-associated degradation maintains postnatal muscle hypertrophy and systemic energy metabolism.
Interference of a mammalian circRNA regulates lipid metabolism reprogramming by targeting miR-24-3p/Igf2/PI3K-AKT-mTOR and Igf2bp2/Ucp1 axis.
Transcriptome-based selection and validation of optimal reference genes in perirenal adipose developing of goat (Capra hircus).
Comprehensive Analysis and Validation of Solute Carrier Family 25 (SLC25) and Its Correlation with Immune Infiltration in Pan-Cancer.
Ceiling culture of human mature white adipocytes with a browning agent: A novel approach to induce transdifferentiation into beige adipocytes.
Naringenin activates beige adipocyte browning in high fat diet-fed C57BL/6 mice by shaping the gut microbiota.
Artemisia sphaerocephala Krasch polysaccharide promotes adipose thermogenesis and decreases obesity by shaping the gut microbiota.
Irisin reduces the abnormal reproductive and metabolic phenotypes of PCOS by regulating the activity of brown adipose tissue in mice†.
A tumor-suppressive function for Notch3 in the parous mammary gland.
Dysregulated adipose tissue expansion and impaired adipogenesis in Prader-Willi syndrome children before obesity-onset.
Functional Attenuation of UCP1 as the Potential Mechanism for a Thickened Blubber Layer in Cetaceans.
Adenosine-rich extract of Ganoderma lucidum: A safe and effective lipid-lowering substance.
Pu-erh tea increases the metabolite Cinnabarinic acid to improve circadian rhythm disorder-induced obesity.
Lytic cocktail: An effective method to alleviate severe burn induced hyper-metabolism through regulating white adipose tissue browning.
Effects of maternal feed intake restriction on the blood parameters, fatty acid profile and lipogenetic genes expression of perirenal fat in offspring kids.
Knockdown of VEGFB/VEGFR1 Signaling Promotes White Adipose Tissue Browning and Skeletal Muscle Development.
Parathyroid hormone-related protein prevents high-fat-diet-induced obesity, hepatic steatosis and insulin resistance in mice.
Dopamine receptor D1 signaling stimulates lipolysis and browning of white adipocytes.
Inhibition of high-fat diet-induced obesity via reduction of ER-resident protein Nogo occurs through multiple mechanisms.
Dietary succinate supplementation to maternal mice improves fetal brown adipose tissue development and thermogenesis of female offspring.
Quercetin, Engelitin and Caffeic Acid of Smilax china L. Polyphenols, Stimulate 3T3-L1 Adipocytes to Brown-like Adipocytes Via β3-AR/AMPK Signaling Pathway.
miR-669a-5p promotes adipogenic differentiation and induces browning in preadipocytes.
Cold exposure prevents fat accumulation in striped hamsters refed a high-fat diet following food restriction.
Gold nanoclusters eliminate obesity induced by antipsychotics.
Transcription Factor E2F1 Knockout Promotes Mice White Adipose Tissue Browning Through Autophagy Inhibition.
Empagliflozin Induces White Adipocyte Browning and Modulates Mitochondrial Dynamics in KK Cg-Ay/J Mice and Mouse Adipocytes.
DMRT2 Interacts With FXR and Improves Insulin Resistance in Adipocytes and a Mouse Model.
Vitellogenin 2 promotes muscle development and stimulates the browning of white fat.
Vitamin D/VDR regulates peripheral energy homeostasis via central renin-angiotensin system.
Exposure to melamine cyanuric acid in adult mice induced thyroid dysfunction and circadian rhythm disorder.
Aqueous extracts of Aconite promote thermogenesis in rats with hypothermia via regulating gut microbiota and bile acid metabolism.
Curcumin improves adipocytes browning and mitochondrial function in 3T3-L1 cells and obese rodent model.
A flavonoid-rich Smilax china L. extract prevents obesity by upregulating the adiponectin-receptor/AMPK signalling pathway and modulating the gut microbiota in mice.
Improvement of obesity-associated disorders by a small-molecule drug targeting mitochondria of adipose tissue macrophages.
Skip participates in formation and lipid metabolism of beige adipose and might mediate the effects of SIRT1 activator BTM-0512 on beige remodeling.
Nobiletin activates thermogenesis of brown and white adipose tissue in high-fat diet-fed C57BL/6 mice by shaping the gut microbiota.
Gentisic acid prevents diet-induced obesity in mice by accelerating the thermogenesis of brown adipose tissue.
Cbl Proto-Oncogene B (CBLB) c.197A>T Mutation Induces Mild Metabolic Dysfunction in Partial Type I Multiple Symmetric Lipomatosis (MSL).
Anti-Adipogenic Effect of Theabrownin Is Mediated by Bile Acid Alternative Synthesis via Gut Microbiota Remodeling.
A dysregulated bile acid-gut microbiota axis contributes to obesity susceptibility.
Supplementation with Extracellular Vesicles Derived from Adipose-Derived Stem Cells Increases Fat Graft Survival and Browning in Mice: A Cell-Free Approach to Construct Beige Fat from White Fat Grafting.
ChREBP-β regulates thermogenesis in brown adipose tissue.
TSH promotes adiposity by inhibiting the browning of white fat.
Feeding induces cholesterol biosynthesis via the mTORC1-USP20-HMGCR axis.
p66Shc Contributes to Liver Fibrosis through the Regulation of Mitochondrial Reactive Oxygen Species.
Lipid Profiling Reveals Browning Heterogeneity of White Adipose Tissue by Β3-Adrenergic Stimulation.
Metabolic and endocrinal effects of N-desmethyl-olanzapine in mice with obesity: Implication for olanzapine-associated metabolic changes.
Regulating glycolysis, the TLR4 signal pathway and expression of RBM3 in mouse liver in response to acute cold exposure.
Gpnmb secreted from liver promotes lipogenesis in white adipose tissue and aggravates obesity and insulin resistance.
Deficiency of heat shock protein A12A promotes browning of white adipose tissues in mice.
Gdf11 gene transfer prevents high fat diet-induced obesity and improves metabolic homeostasis in obese and STZ-induced diabetic mice.
Identification of a natural beige adipose depot in mice.
Zinc-α2-Glycoprotein Is Associated with Obesity in Chinese People and HFD-Induced Obese Mice.
The Protective Effects of Danggui-Baizhu-Tang on High-Fat Diet-Induced Obesity in Mice by Activating Thermogenesis.
Renoprotective Effect of Danhong Injection on Streptozotocin-Induced Diabetic Rats through a Peroxisome Proliferator-Activated Receptor γ Mediated Pathway.
Exosomes From Adipose-Derived Stem Cells Attenuate Adipose Inflammation and Obesity Through Polarizing M2 Macrophages and Beiging in White Adipose Tissue.
Antiobesity effect of Lactobacillus reuteri 263 associated with energy metabolism remodeling of white adipose tissue in high-energy-diet-fed rats.
Green tea extract induces genes related to browning of white adipose tissue and limits weight-gain in high energy diet-fed rat.
Pdcd4 restrains the self-renewal and white-to-beige transdifferentiation of adipose-derived stem cells.
Liraglutide suppresses obesity and induces brown fat-like phenotype via Soluble Guanylyl Cyclase mediated pathway in vivo and in vitro.
Programmed cell death-4 deficiency prevents diet-induced obesity, adipose tissue inflammation, and insulin resistance.
Zinc-alpha2-glycoprotein is involved in regulation of body weight through inhibition of lipogenic enzymes in adipose tissue.
Cheng L, Gan M, Wang H, Song Y, Bai Y, Zhang D
Phytotherapy research : PTR 2026 May;40(5):2397-2416
Phytotherapy research : PTR 2026 May;40(5):2397-2416
Exosomal miR-1246 of adipose stem cells attenuates obesity by polarizing M2 macrophages, reducing fat mass, and beiging of white adipose tissue.
Wang B, Pi Q, Mohsin A, Gao WQ, Guo M, Xu H
Journal of advanced research 2026 Mar;81:195-209
Journal of advanced research 2026 Mar;81:195-209
PTG-Dependent Glycogen Metabolic Dysfunction Drives Impaired Adipose Browning: A Novel Mechanism Linking PM(2.5) to Metabolic Disorders.
Wang L, Hu R, Chai Y, He P, Li S, Zhao L, Zhao W, Zhang L, Qin L, Li R, Hou X, Sun Q, Liu C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar;13(16):e12589
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar;13(16):e12589
Dendrobium officinale polysaccharide ameliorate hyperlipidemia through LKB1/AMPK and CD36/PGC-1α/UCP1 activation and gut microbiota modulation.
Gong Y, Fang H, Wu L, Zhang J, Wen Y, Rao Y, Zhao Y
Naunyn-Schmiedeberg's archives of pharmacology 2026 Mar 4;
Naunyn-Schmiedeberg's archives of pharmacology 2026 Mar 4;
Metabolic beneficial effects of targeting a long non-coding RNA, lnc-megacluster, in obesity.
Abdollahi M, Malek V, Tanwar VS, Kato M, Lanting L, Rezaei A, Zhang L, Yang L, Pillai RK, Kebrom L, Nandi J, Huang W, Ma K, Natarajan R
Molecular therapy. Nucleic acids 2026 Mar 12;37(1):102792
Molecular therapy. Nucleic acids 2026 Mar 12;37(1):102792
Growth hormone enhances mitochondria biogenesis and endows mitochondrial thermogenesis in murine adipocytes.
Sadiq E, Liu Y, Li N, Zong C, Li X, Yu T, Pu Z, Alameri L, Li Z, Li S, Wang X, Zhao R
Molecular and cellular endocrinology 2026 Jun;616:112758
Molecular and cellular endocrinology 2026 Jun;616:112758
Flavonoid-rich extracts of Nelumbo nucifera leaves alleviate obesity in HFD-fed mice via microbiota-dependent modulation of brown fat thermogenesis.
Wang Z, Ren X, Peng Z, Zeng M, Wang Z, Chen Q, Chen J, Dai X, Christian M, Qie X, He Z
Journal of ethnopharmacology 2026 Jan 10;354:120513
Journal of ethnopharmacology 2026 Jan 10;354:120513
Exclusive Breastfeeding Drives AMPK-Dependent Thermogenic Memory in BAT and Promotes Long-Term Metabolic Benefits in Offspring.
Wu N, Yin A, Yu X, Wang M, Zhang J, Liu K, Hou Y, Cao M, Zhang Y, Zhang X, Gao Y, Guo X, Zhang L, Li Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(12):e08956
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(12):e08956
WTAP Maintains Alternative Activation of Macrophages by Promoting IDH1-Mediated α-ketoglutarate Production.
Xu Q, Zhang J, Zou Y, Chen L, Sun F, Luo X, Wang T, Li Y, Zhang S, Xiong F, Yu Q, Yang P, Gong Q, Liu SW, Wang CY
International journal of biological sciences 2025;21(12):5428-5443
International journal of biological sciences 2025;21(12):5428-5443
Human milk-derived 5'-UMP promotes thermogenesis and mitochondrial biogenesis to ameliorate obesity.
Zhang L, Peng Z, Lin C, Hu H, Du J, Huang S, Huang S, Gao J, Guo X
Frontiers in nutrition 2025;12:1661778
Frontiers in nutrition 2025;12:1661778
Targeting Dlat-Trpv3 pathway by hyperforin elicits non-canonical promotion of adipose thermogenesis as an effective anti-obesity strategy.
Lu S, Jiang Q, Zhou P, Yin L, Wang N, Xu J, Qian Q, Tao M, Yin H, Han L, Gu Y, Gao F, Liu J, Chen S
Journal of advanced research 2025 Sep;75:793-809
Journal of advanced research 2025 Sep;75:793-809
Gut microbiota modified by Mulberry leaf water extract improves T2DM through browning of WAT/BAT activation mediated by SCFAs-AMPK/SIRT1/PGC-1α signaling pathway.
Du Y, He C, An Y, Zhao Y, Zhang H, Shan Z, Yang Y, Wang M, Xie J, Huang Y, Fu W, Yuan Y, Zhao B
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120408
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120408
Bisphenol A increases fat mass in adipose tissue by disturbing gut microbiota-dependent bile acid metabolism and TGR5/UCP1 signaling pathways in CD-1 mice.
Chen X, Zou J, Hong T, Zhang H, Yang J, Mai H, Shi H, Li X, Feng D
Ecotoxicology and environmental safety 2025 Sep 15;303:118922
Ecotoxicology and environmental safety 2025 Sep 15;303:118922
Downregulation of uncoupling protein 1 by hypermethylation in gastric cancer activates Rap1 signaling.
Chen YJ, Peng C, Wang LW, Chai JX, Wang JD, He QB
World journal of gastrointestinal oncology 2025 Sep 15;17(9):108760
World journal of gastrointestinal oncology 2025 Sep 15;17(9):108760
Phosphatidylethanolamine/PKA signal axis mediated human milk extracellular vesicles enhance adipose thermogenesis and lipolysis via mitochondrial remodeling.
Peng Z, Gao J, Xu L, Huang S, Wang R, Du J, Zhang Z, Zhang L, Feng L, Wang X, Guo X
International journal of obesity (2005) 2025 Oct;49(10):2081-2093
International journal of obesity (2005) 2025 Oct;49(10):2081-2093
A Novel Glucomannan from Dendrobium officinale Inhibits Obesity and Improves Insulin Sensitivity through Regulating Adipogenesis and Lipid Metabolism.
Chen J, Zhang M, Yang Y, Peng H, Zhang J, Shou Y, Tang Y, Du X, Guo C, Wang X
Journal of agricultural and food chemistry 2025 Oct 29;73(43):27751-27770
Journal of agricultural and food chemistry 2025 Oct 29;73(43):27751-27770
Gut symbiont-derived ursodeoxycholic acid promotes fatty acid oxidation to protect against renal ischemia-reperfusion injury.
Xie M, Zheng J, Yu Y, Yang Q, Zhou Z, Xue J, Wang B, Qiu Y, Zhu Z, Sun Q, Shi X, Shangguan W, Li L, Zou Z, Zhao J, Wu P
Cell reports. Medicine 2025 Oct 21;6(10):102373
Cell reports. Medicine 2025 Oct 21;6(10):102373
Cetacean loss of the master adipose tissue regulator β(3)-adrenergic receptor may underlie their thick blubber and an Oligocene radiation and dispersal.
Tian R, Zhang T, Dong H, Seim I, Yang G
Nature communications 2025 Oct 17;16(1):9235
Nature communications 2025 Oct 17;16(1):9235
Loss of histone methyltransferase Smyd3 triggers WAT browning and adaptive thermogenesis via enhancing PPARγ expression in a H4K20me3-dependent manner.
Shu M, Ma Y, Zhao D, Meng C, Chen L, Wang L, Liu J, Yang D
Journal of translational medicine 2025 Oct 1;23(1):1041
Journal of translational medicine 2025 Oct 1;23(1):1041
Eurotium Cristatum fermented instant dark tea prevents obesity and promotes adipose thermogenesis via modulating the gut microbiota.
Wang X, Li Y, Yu P, Zhang L, Wang Y, Yang X, Ren D
Food research international (Ottawa, Ont.) 2025 Nov;219:116969
Food research international (Ottawa, Ont.) 2025 Nov;219:116969
Quercetin ameliorates renal injury by promoting UCP1-mediated alleviation of lipid accumulation in diabetic kidney disease.
Yong W, Li Z, Xu W, Gao D, Sha B, Jin Y, Shen Y, Zhang Y, Pan Y, Liu J, Zhang F, Yu J, Jin L, Yang Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov;147:157213
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov;147:157213
Avian GCGR-mediated continuous fat utilization offers perspectives for obesity treatment.
Zhang C, Wang X, Feng C, Zheng H, Leng S, Jiang Y, Sun Q, Li X, Zhang T, Zhang J, Chen H, Lai S, Makalowski W, Brosius J, Shi Y, He Y, Hu P, Sun Q, Deng C
Nature communications 2025 Nov 28;16(1):11706
Nature communications 2025 Nov 28;16(1):11706
Structural characterization and alleviative effects of novel polysaccharides from Artemisia sphaerocephala Krasch seed on obese mice by regulating gut microbiota.
Zeng X, Yu P, Li D, Li Y, Wang X, Yang X, Ren D
International journal of biological macromolecules 2025 May;310(Pt 4):143407
International journal of biological macromolecules 2025 May;310(Pt 4):143407
Etomoxir suppresses the expression of PPARγ2 and inhibits the thermogenic gene induction of brown adipocytes through pathways other than β-oxidation inhibition.
Shimura H, Yamamoto S, Shiiba I, Oikawa M, Uchinomiya S, Ojida A, Yanagi S, Kadowaki H, Nishitoh H, Fukuda T, Nagashima S, Yamaguchi T
Journal of biochemistry 2025 Mar 4;177(3):203-212
Journal of biochemistry 2025 Mar 4;177(3):203-212
The clinical antiprotozoal drug halofuginone promotes weight loss by elevating GDF15 and FGF21.
Xu S, Liu Z, Tian T, Zhao W, Wang Z, Liu M, Xu M, Zhang F, Zhang Z, Chen M, Yin Y, Su M, Fang W, Pan W, Liu S, Li MD, Little PJ, Kamato D, Zhang S, Wang D, Offermanns S, Speakman JR, Weng J
Science advances 2025 Mar 28;11(13):eadt3142
Science advances 2025 Mar 28;11(13):eadt3142
Brown adipose tissue transplantation ameliorates hindlimb ischemic damage in diabetic mice.
Lu T, Liu A, Li C, Li Y, Yang B, Liu Q, Jiang H
Scientific reports 2025 Mar 14;15(1):8820
Scientific reports 2025 Mar 14;15(1):8820
Barley polysaccharides modulate metabolic and mild cognitive impairment in naturally aging mice through the liver-gut-brain axis.
Fan M, Jiang Y, Cai C, Wang Z, Chen L, Zhang X, Yin H, Hu S, Liu J, Qian Z, Huang S
International journal of biological macromolecules 2025 Jun;311(Pt 3):144008
International journal of biological macromolecules 2025 Jun;311(Pt 3):144008
Time-restricted feeding mitigates HFD-induced sarcopenic obesity in aging mice through improving the sensitivity of FGF21.
Wang T, Lin H, Deng Y, Chen W, Xu Y, Wang L, Zhou A, Zhang Y, Wang Z, Jin X, Zhang L, Wang X, Zhou Y, Wang R, Rong S
The Journal of nutritional biochemistry 2025 Jun;140:109893
The Journal of nutritional biochemistry 2025 Jun;140:109893
Brown adipose tissue secretes OLFM4 to coordinate sensory and sympathetic innervation via Schwann cells.
Lai M, Zhou W, Zou W, Qiu L, Liang Z, Chen W, Wang Y, Guo B, Zhao C, Zhang S, Lai P, Hu L, Liu X, Jiang Y, Chen Y, Huang MJ, Bai X, Zou Z
Nature communications 2025 Jun 4;16(1):5206
Nature communications 2025 Jun 4;16(1):5206
UCP1 prevents the formation of thoracic aortic aneurysms and dissection by inhibiting the TLR4/NLRP3/IL-1β signaling pathway and VSMC phenotype switching in mice.
Xiang J, Yue H, Jiang D, Zheng S, Wu Z
Biochemical pharmacology 2025 Jul;237:116929
Biochemical pharmacology 2025 Jul;237:116929
Anthraquinones of Cassiae Semen alleviate lipid accumulation in obesity by regulating brown adipose tissue and liver function.
Li Y, Wu R, Li X, Li J, Zhang Y, Huang Y, Fan G, Li X
Chinese herbal medicines 2025 Jul;17(3):488-499
Chinese herbal medicines 2025 Jul;17(3):488-499
Medium-chain triglyceride attenuates obesity by activating brown adipose tissue via upregulating the AMPK signaling pathway.
Jia M, Yue H, Wang X, Zong A, Xu T, Xu YJ, Liu Y
The Journal of nutritional biochemistry 2025 Jul;141:109914
The Journal of nutritional biochemistry 2025 Jul;141:109914
Polystyrene microplastics impair brown and beige adipocyte function via the gut microbiota-adipose tissue crosstalk in high-fat diet mice.
Kou G, Yao S, Ullah A, Fang S, Guo E, Bo Y
Journal of hazardous materials 2025 Jul 15;492:138225
Journal of hazardous materials 2025 Jul 15;492:138225
Resveratrol stimulates brown of white adipose via regulating ERK/DRP1-mediated mitochondrial fission and improves systemic glucose homeostasis.
Yan H, Shao M, Lin X, Peng T, Chen C, Yang M, Zhong J, Yang J, Hui S
Endocrine 2025 Jan;87(1):144-158
Endocrine 2025 Jan;87(1):144-158
Integrating network pharmacology and transcriptomics to study the potential mechanism of Jingzhi Niuhuang Jiedu tablet in rats with accumulation of heat in the lungs and stomach.
Dai ZQ, Guo ZQ, Zhang T, Chu YF, Yan Y, Gao F, Li SL, Gu YH, Jiao JY, Lin YX, Zhao SW, Xu B, Lei HM
Journal of ethnopharmacology 2025 Jan 30;337(Pt 2):118890
Journal of ethnopharmacology 2025 Jan 30;337(Pt 2):118890
Maternal neonicotinoid pesticide exposure impairs glucose metabolism by deteriorating brown fat thermogenesis.
Zhu W, Fang J, Ji C, Zhong H, Zhong T, Cui X
Ecotoxicology and environmental safety 2025 Jan 15;290:117596
Ecotoxicology and environmental safety 2025 Jan 15;290:117596
Isoliquiritigenin Ameliorates High-Fat Diet-Induced Obesity in Mice by Activating Brown Adipose Tissue.
Zhao L, Li M, Zhu Q, Fang X, Yang H, Zhao Y
International journal of molecular sciences 2025 Feb 14;26(4)
International journal of molecular sciences 2025 Feb 14;26(4)
MDPAO1 peptide from human milk enhances brown adipose tissue thermogenesis and mitigates obesity.
Gao Y, Zhang J, Cao M, Zhang Y, Cao M, Gu W, Wang M
Molecular and cellular endocrinology 2025 Feb 1;597:112443
Molecular and cellular endocrinology 2025 Feb 1;597:112443
Baicalin alleviates sepsis-associated acute kidney injury through activation of the PPAR-γ/UCP1 signaling pathway.
Bao N, Gu MJ, Huang QY, Sun HJ, Zhu XX, Gu X, Wang J, Yu X, Lu QB, Yu YF
Renal failure 2025 Dec;47(1):2508908
Renal failure 2025 Dec;47(1):2508908
Curcumin Inhibits Bisphenol A-Induced Fat Mass Gain by Enhancing White Adipose Tissue Browning via Modulating Gut Microbiota-Dependent Bile Acid Metabolism in CD-1 Mice.
Chen X, Zou J, Cao Z, Hong T, Zhang H, Yang J, Mai H, Li X, Feng D
Journal of medicinal food 2025 Dec;28(12):1244-1255
Journal of medicinal food 2025 Dec;28(12):1244-1255
The suprachiasmatic nucleus regulates brown fat thermogenesis in male mice through an adrenergic receptor ADRB3-S100B signaling pathway.
Zeng Y, Song X, Chen Q, Gu Y, Zhang J, Zhou T, Li Z, Wang T, Chang L, Yao H, Wang Y, Miao L, Qian L, Guo T, Zhang Y, Rodriguez-Fernandez S, Vidal-Puig A, Xu Y
PLoS biology 2025 Dec;23(12):e3003534
PLoS biology 2025 Dec;23(12):e3003534
Dietary cannabidiol oil mitigates metabolic dysfunction in mice with high-fat diet-induced obesity.
Bravo Iniguez A, Sun Q, Tian Q, Du M, Zhu MJ
The Journal of nutritional biochemistry 2025 Dec;146:110040
The Journal of nutritional biochemistry 2025 Dec;146:110040
WDR4-mediate tRNA m7G modification to promote mitophagy and browning of white adipose tissue for ameliorating obesity in male mice.
Lin B, Wang C, Yang Y, Liu Z, Mu P, Xu W, Li Y
Adipocyte 2025 Dec;14(1):2588888
Adipocyte 2025 Dec;14(1):2588888
NRF2-REGγ-ACADM/KLF15 Signaling Pathway Regulates the Browning of White Adipose Tissue to Modulate Obesity.
Chen H, Guan Q, Gong S, Du Y, Zhang Z, Liu Y, Zhou L, Liu L, Xin B, Guo Y, Zhang H, Zhou Z, Pei T, Yu G, Yin S, Li L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(46):e09429
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(46):e09429
Blubber Thickening Driven by UCP1 Inactivation: Insights from a Cetacean-Like Transgenic Mouse Model.
Zhang Q, Wang Y, Zhang H, Xu G, Xu S, Yang G
Integrative zoology 2025 Dec 8;
Integrative zoology 2025 Dec 8;
Blocking glycogen synthase 1 in white adipose tissue alleviates hypermetabolism following severe burn injury through inhibition of JAK2 by UDPG.
Zhuo S, Wang Z, Yang L, Yuan Y, Hu D, Chen Y
Cell reports 2025 Dec 23;44(12):116577
Cell reports 2025 Dec 23;44(12):116577
Eurotium cristatum Ameliorates Glucolipid Metabolic Dysfunction of Obese Mice in Association with Regulating Intestinal Gluconeogenesis and Microbiome.
Yang W, Han N, Zhang X
Foods (Basel, Switzerland) 2025 Dec 12;14(24)
Foods (Basel, Switzerland) 2025 Dec 12;14(24)
Nrg4 Secreted by Brown Adipose Tissue Suppresses Ferroptosis of Sepsis-Induced Liver Injury.
Feng L, Cui J, Chen W, Zhu L, Li P, Zhou H, Sun Y, Yi W
Inflammation 2025 Aug;48(4):2783-2801
Inflammation 2025 Aug;48(4):2783-2801
Combination of Berberine and Evodiamine Alleviates Obesity by Promoting Browning in 3T3-L1 Cells and High-Fat Diet-Induced Mice.
Zhang H, Xiong P, Zheng T, Hu Y, Guo P, Shen T, Zhou X
International journal of molecular sciences 2025 Apr 28;26(9)
International journal of molecular sciences 2025 Apr 28;26(9)
Green Tea Ameliorates Depression-Like Behavior and Cognitive Impairment Induced by High-Fat Diet and Chronic Mild Stress.
Fan M, Jiang Y, Cai C, Wang Z, Chen L, Hu S, Zhang X, Yin H, Qian Z, Huang S, Yang J
Phytotherapy research : PTR 2025 Apr 17;
Phytotherapy research : PTR 2025 Apr 17;
Ling-gui-zhu-gan granules reduces obesity and ameliorates metabolic disorders by inducing white adipose tissue browning in obese mice.
Li Y, Ye Z, Zhao Y, Xu B, Xue W, Wang Z, An R, Wang F, Wu R
Frontiers in physiology 2024;15:1427722
Frontiers in physiology 2024;15:1427722
TRPC absence induces pro-inflammatory macrophage polarization to promote obesity and exacerbate colorectal cancer.
Lin Y, Gao R, Jing D, Liu Y, Da H, Birnbaumer L, Yang Y, Gao X, Gao Z, Cao Q
Frontiers in pharmacology 2024;15:1392328
Frontiers in pharmacology 2024;15:1392328
Ling-gui-zhu-gan promotes adipocytes browning via targeting the miR-27b/PRDM16 pathway in 3T3-L1 cells.
Ye Z, Zhao Y, Cui Y, Xu B, Wang F, Zhao D, Dong G, Wang Z, Wu R
Frontiers in pharmacology 2024;15:1386794
Frontiers in pharmacology 2024;15:1386794
Xiasangju alleviate metabolic syndrome by enhancing noradrenaline biosynthesis and activating brown adipose tissue.
He C, An Y, Shi L, Huang Y, Zhang H, Fu W, Wang M, Shan Z, Du Y, Xie J, Huang Z, Sun W, Zhao Y, Zhao B
Frontiers in pharmacology 2024;15:1371929
Frontiers in pharmacology 2024;15:1371929
Exercise attenuates high-fat diet-induced PVAT dysfunction through improved inflammatory response and BMP4-regulated adipose tissue browning.
Liu X, Jiang X, Hu J, Ding M, Lee SK, Korivi M, Qian Y, Li T, Wang L, Li W
Frontiers in nutrition 2024;11:1393343
Frontiers in nutrition 2024;11:1393343
siRNA nanoparticle targeting Usp20 lowers lipid levels and ameliorates metabolic syndrome in mice.
Ding Y, Chen QB, Xu H, Adi D, Ding YW, Luo WJ, Zhu WZ, Xu JC, Zhao X, Shi XJ, Luo J, Yin H, Lu XY
Journal of lipid research 2024 Sep;65(9):100626
Journal of lipid research 2024 Sep;65(9):100626
Single-Cell Landscape and a Macrophage Subset Enhancing Brown Adipocyte Function in Diabetes.
Gu J, Jin J, Ren X, Zhang X, Li J, Wang X, Zhang S, Yin X, Zhang Q, Wang Z
Diabetes & metabolism journal 2024 Sep;48(5):885-900
Diabetes & metabolism journal 2024 Sep;48(5):885-900
Lactating striped hamsters (Cricetulus barabensis) do not decrease the thermogenic capacity to cope with extreme cold temperature.
Liu W, Liao SS, Bao MH, Huo DL, Cao J, Zhao ZJ
Zoology (Jena, Germany) 2024 Sep;166:126195
Zoology (Jena, Germany) 2024 Sep;166:126195
Synthesis and anti-proliferative effect of novel 4-Aryl-1, 3-Thiazole-TPP conjugates via mitochondrial uncoupling process.
Hu Y, Zhang Y, Guo J, Chen S, Jin J, Li P, Pan Y, Lei S, Li J, Wu S, Bu B, Fu L
Bioorganic chemistry 2024 Sep;150:107588
Bioorganic chemistry 2024 Sep;150:107588
GRP75 triggers white adipose tissue browning to promote cancer-associated cachexia.
Chen X, Wu Q, Gong W, Ju S, Fan J, Gao X, Liu X, Lei X, Liu S, Ming X, Wang Q, Fu M, Song Y, Wang Y, Zhan Q
Signal transduction and targeted therapy 2024 Sep 26;9(1):253
Signal transduction and targeted therapy 2024 Sep 26;9(1):253
Renal denervation alleviates vascular remodeling in spontaneously hypertensive rats by regulating perivascular adipose tissue.
Jiang T, Wei Y, Xu R, Jin Y, Song T, Wang H, Chen W, Tian H, Xu L, Zhao Y, Fu Y
Hypertension research : official journal of the Japanese Society of Hypertension 2024 Oct;47(10):2760-2772
Hypertension research : official journal of the Japanese Society of Hypertension 2024 Oct;47(10):2760-2772
Effective Prevention and Treatment of Acute Leukemias in Mice by Activation of Thermogenic Adipose Tissues.
Chen R, Cheng T, Xie S, Sun X, Chen M, Zhao S, Ruan Q, Ni X, Rao M, Quan X, Chen K, Zhang S, Cheng T, Xu Y, Chen Y, Yang Y, Cao Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Oct;11(38):e2402332
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Oct;11(38):e2402332
Effects of the Fungicide Prothioconazole on Lipid Metabolism in Mice: Whitening Alterations of Brown Adipose Tissue.
Song SL, Chen XY, Zhao J, Li YY, Xiong YM, Lv L, Chang J, Wang H, Li XH, Qin ZF
Environmental science & technology 2024 Oct 15;58(41):18155-18166
Environmental science & technology 2024 Oct 15;58(41):18155-18166
SGLT2 inhibitor canagliflozin reduces visceral adipose tissue in db/db mice by modulating AMPK/KLF4 signaling and regulating mitochondrial dynamics to induce browning.
Qu J, Tian L, Zhang M, Sun B, Chen L
Molecular and cellular endocrinology 2024 Oct 1;592:112320
Molecular and cellular endocrinology 2024 Oct 1;592:112320
Characterization of Ucp1-iCre knockin mice reveals the recombination activity in male germ cells.
Li MY, Lu M, Cao DM, Han Q, Ma XH, Wei CC, Zhang WJ
American journal of physiology. Endocrinology and metabolism 2024 Oct 1;327(4):E544-E551
American journal of physiology. Endocrinology and metabolism 2024 Oct 1;327(4):E544-E551
Procyanidin B2 improves developmental capacity of bovine oocytes via promoting PPARγ/UCP1-mediated uncoupling lipid catabolism during in vitro maturation.
Luo Y, Li J, Zheng L, Reyimjan Y, Ma Y, Huang S, Liu H, Zhou G, Bai J, Zhu Y, Sun Y, Zou X, Hou Y, Fu X
Cell proliferation 2024 Nov;57(11):e13687
Cell proliferation 2024 Nov;57(11):e13687
Sestrin2 in POMC neurons modulates energy balance and obesity related metabolic disorders via mTOR signaling.
Hu H, Lu X, He Y, Li J, Wang S, Luo Z, Wang Y, Wei J, Huang H, Duan C, Sun N
The Journal of nutritional biochemistry 2024 Nov;133:109703
The Journal of nutritional biochemistry 2024 Nov;133:109703
Sexual dimorphism in thermogenic regulators and metrnl expression in adipose tissue of offspring mice exposed to maternal and postnatal overnutrition.
Yang Z, Jiang J, Tan Y, Yang G, Chen M, Huang J, Liu J, Wei X, Wang S, Luo X, Han Z
Journal of physiology and biochemistry 2024 May;80(2):407-420
Journal of physiology and biochemistry 2024 May;80(2):407-420
Exercise-inducible circulating extracellular vesicle irisin promotes browning and the thermogenic program in white adipose tissue.
Shi H, Hao X, Sun Y, Zhao Y, Wang Y, Cao X, Gong Z, Ji S, Lu J, Yan Y, Yu X, Luo X, Wang J, Wang H
Acta physiologica (Oxford, England) 2024 Mar;240(3):e14103
Acta physiologica (Oxford, England) 2024 Mar;240(3):e14103
Loss of FoxO1 activates an alternate mechanism of mitochondrial quality control for healthy adipose browning.
Shi L, Yang J, Tao Z, Zheng L, Bui TF, Alonso RL, Yue F, Cheng Z
Clinical science (London, England : 1979) 2024 Mar 20;138(6):371-385
Clinical science (London, England : 1979) 2024 Mar 20;138(6):371-385
Global gene expression profiling of perirenal brown adipose tissue whitening in goat kids reveals novel genes linked to adipose remodeling.
Zhao L, Yang H, Li M, Xiao M, Li X, Cheng L, Cheng W, Chen M, Zhao Y
Journal of animal science and biotechnology 2024 Mar 14;15(1):47
Journal of animal science and biotechnology 2024 Mar 14;15(1):47
Eugenol mimics exercise to promote skeletal muscle fiber remodeling and myokine IL-15 expression by activating TRPV1 channel.
Huang T, Chen X, He J, Zheng P, Luo Y, Wu A, Yan H, Yu B, Chen D, Huang Z
eLife 2024 Jun 24;12
eLife 2024 Jun 24;12
Structural Variances in Curcumin Degradants: Impact on Obesity in Mice.
Koh YC, Hsu HW, Ho PY, Hsu KY, Lin WS, Nagabhushanam K, Ho CT, Pan MH
Journal of agricultural and food chemistry 2024 Jul 3;72(26):14786-14798
Journal of agricultural and food chemistry 2024 Jul 3;72(26):14786-14798
Ginsenoside Rb1 regulates CPT1A deacetylation to inhibit intramuscular fat infiltration after rotator cuff tear.
Yin Y, Wang Z, Yang Y, Shen M, Hu H, Chen C, Zhou H, Li Z, Wu S
iScience 2024 Jul 19;27(7):110331
iScience 2024 Jul 19;27(7):110331
Alisol B 23-acetate promotes white adipose tissue browning to mitigate high-fat diet-induced obesity by regulating mTOR-SREBP1 signaling.
Han LL, Zhang X, Zhang H, Li T, Zhao YC, Tian MH, Sun FL, Feng B
Journal of integrative medicine 2024 Jan;22(1):83-92
Journal of integrative medicine 2024 Jan;22(1):83-92
MIIP downregulation drives colorectal cancer progression through inducing peri-cancerous adipose tissue browning.
Wang Q, Su Y, Sun R, Xiong X, Guo K, Wei M, Yang G, Ru Y, Zhang Z, Li J, Zhang J, Qiao Q, Li X
Cell & bioscience 2024 Jan 20;14(1):12
Cell & bioscience 2024 Jan 20;14(1):12
Dysregulation of mitochondrial dynamics mediated aortic perivascular adipose tissue-associated vascular reactivity impairment under excessive fructose intake.
Wu KLH, Wu CW, Chen LW, Chang HH, Cheng CL, Wu CY, Lee YC, Chen IC, Hung CY, Liu WC
Nutrition & metabolism 2024 Jan 2;21(1):4
Nutrition & metabolism 2024 Jan 2;21(1):4
Brown adipose Vanin-1 is required for the maintenance of mitochondrial homeostasis and prevents diet-induced metabolic dysfunction.
Sun C, Liang J, Zheng J, Mao S, Chen S, Aikemu A, Liu C
Molecular metabolism 2024 Feb;80:101884
Molecular metabolism 2024 Feb;80:101884
miR-1182-mediated ALDH3A2 inhibition affects lipid metabolism and progression in ccRCC by activating the PI3K-AKT pathway.
Lv Q, Shi J, Miao D, Tan D, Zhao C, Xiong Z, Zhang X
Translational oncology 2024 Feb;40:101835
Translational oncology 2024 Feb;40:101835
Whitening of brown adipose tissue inhibits osteogenic differentiation via secretion of S100A8/A9.
Wang T, Zhao C, Zhang J, Li S, Zhang Y, Gong Y, Zhou Y, Yan L, Zhang S, Zhang Z, Hu H, Liu A, Bai X, Zou Z
iScience 2024 Feb 16;27(2):108857
iScience 2024 Feb 16;27(2):108857
Body size influences the capacity to cope with extreme cold or hot temperatures in the striped hamster.
Hu C, Zhang R, Zhang W, Zheng Y, Cao J, Zhao Z
Journal of thermal biology 2024 Dec;126:104008
Journal of thermal biology 2024 Dec;126:104008
Adipose Tissue-Resident Sphingomonas Paucimobilis Suppresses Adaptive Thermogenesis by Reducing 15-HETE Production and Inhibiting AMPK Pathway.
Zhu Y, Yang R, Deng Z, Deng B, Zhao K, Dai C, Wei G, Wang Y, Zheng J, Ren Z, Lv W, Xiao Y, Mei Z, Song T
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Dec;11(47):e2310236
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Dec;11(47):e2310236
Sodium Houttuybonate Promotes the Browning of White Adipose Tissue by Inhibiting Ferroptosis via the AMPK-NRF2-HO1 Pathway.
Liu W, Zou H, You D, Zhang H, Xu L
Antioxidants (Basel, Switzerland) 2024 Aug 30;13(9)
Antioxidants (Basel, Switzerland) 2024 Aug 30;13(9)
Adipocyte-Targeted Nanocomplex with Synergistic Photothermal and Pharmacological Effects for Combating Obesity and Related Metabolic Syndromes.
Zhang Y, Zeng X, Wu F, Yang X, Che T, Zheng Y, Li J, Zhang Y, Zhang X, Wu Z
Nanomaterials (Basel, Switzerland) 2024 Aug 19;14(16)
Nanomaterials (Basel, Switzerland) 2024 Aug 19;14(16)
Repurposing lansoprazole to alleviate metabolic syndrome via PHOSPHO1 inhibition.
Wu Y, Xin J, Li X, Yang T, Liu Y, Zhao Y, Xie W, Jiang M
Acta pharmaceutica Sinica. B 2024 Apr;14(4):1711-1725
Acta pharmaceutica Sinica. B 2024 Apr;14(4):1711-1725
Pterostilbene Enhances Thermogenesis and Mitochondrial Biogenesis by Activating the SIRT1/PGC-1α/SIRT3 Pathway to Prevent Western Diet-Induced Obesity.
Koh YC, Lin SJ, Hsu KY, Nagabhushanam K, Ho CT, Pan MH
Molecular nutrition & food research 2023 Sep;67(18):e2300370
Molecular nutrition & food research 2023 Sep;67(18):e2300370
Polysaccharide from Ziyang Selenium-Enriched Green Tea Prevents Obesity and Promotes Adipose Thermogenesis via Modulating the Gut Microbiota.
Li D, Cheng Y, Zeng X, Li Y, Xia Z, Yang X, Ren D
Journal of agricultural and food chemistry 2023 Sep 13;71(36):13363-13375
Journal of agricultural and food chemistry 2023 Sep 13;71(36):13363-13375
Acetyl-coenzyme A acetyltransferase 1 promotes brown adipogenesis by activating the AMPK-PGC1α signaling pathway.
Zhu K, Ni L, Han J, Yan Z, Zhang Y, Wang F, Wang L, Yang X
Biochimica et biophysica acta. Molecular and cell biology of lipids 2023 Oct;1868(10):159369
Biochimica et biophysica acta. Molecular and cell biology of lipids 2023 Oct;1868(10):159369
Geniposide ameliorates atherosclerosis by regulating macrophage polarization via perivascular adipocyte-derived CXCL14.
He P, Wang H, Cheng S, Hu F, Zhang L, Chen W, Xu Y, Zhang Y, Gu Y, Li Z, Jin Y, Liu X, Jia Y
Journal of ethnopharmacology 2023 Oct 5;314:116532
Journal of ethnopharmacology 2023 Oct 5;314:116532
Miquelianin in Folium Nelumbinis extract promotes white-to-beige fat conversion via blocking AMPK/DRP1/mitophagy and modulating gut microbiota in HFD-fed mice.
Wang Z, Yang T, Zeng M, Wang Z, Chen Q, Chen J, Christian M, He Z
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Nov;181:114089
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Nov;181:114089
HDAC1 inhibits beige adipocyte-mediated thermogenesis through histone crotonylation of Pgc1a/Ucp1.
Tian D, Zeng X, Gong Y, Zheng Y, Zhang J, Wu Z
Cellular signalling 2023 Nov;111:110875
Cellular signalling 2023 Nov;111:110875
CX3CR1(hi) macrophages sustain metabolic adaptation by relieving adipose-derived stem cell senescence in visceral adipose tissue.
Zhou Z, Zhang H, Tao Y, Jie H, Zhao J, Zang J, Li H, Wang Y, Wang T, Zhao H, Li Y, Guo C, Zhu F, Mao H, Zhang L, Liu F, Wang Q
Cell reports 2023 May 30;42(5):112424
Cell reports 2023 May 30;42(5):112424
Metrnl Alleviates Lipid Accumulation by Modulating Mitochondrial Homeostasis in Diabetic Nephropathy.
Zhou Y, Liu L, Jin B, Wu Y, Xu L, Chang X, Hu L, Wang G, Huang Y, Song L, Zhang T, Wang Y, Xiao Y, Zhang F, Shi M, Liu L, Wang T, Yan R, Guo B
Diabetes 2023 May 1;72(5):611-626
Diabetes 2023 May 1;72(5):611-626
Bioactivity-based molecular networking-guided identification of guttiferone J from Garcinia cambogia as an anti-obesity candidate.
Feng Z, Chen J, Chen C, Feng L, Wang R, Zhu J, Lou R, Liu J, Ye Y, Lin L
British journal of pharmacology 2023 Mar;180(5):589-608
British journal of pharmacology 2023 Mar;180(5):589-608
Adipocyte YTH N(6)-methyladenosine RNA-binding protein 1 protects against obesity by promoting white adipose tissue beiging in male mice.
Yan S, Zhou X, Wu C, Gao Y, Qian Y, Hou J, Xie R, Han B, Chen Z, Wei S, Gao X
Nature communications 2023 Mar 13;14(1):1379
Nature communications 2023 Mar 13;14(1):1379
FoxO1 regulates adipose transdifferentiation and iron influx by mediating Tgfβ1 signaling pathway.
Shi L, Tao Z, Zheng L, Yang J, Hu X, Scott K, de Kloet A, Krause E, Collins JF, Cheng Z
Redox biology 2023 Jul;63:102727
Redox biology 2023 Jul;63:102727
Hypoxia promotes white adipose tissues browning in rats under simulated environment at altitude of 5000 m.
Song Q, Liu S, Wang J, Chai J, Wen J, Xu C
Biochemical and biophysical research communications 2023 Jul 23;666:146-153
Biochemical and biophysical research communications 2023 Jul 23;666:146-153
T-cell immunoglobulin- and mucin-domain-containing molecule-4 maintains adipose tissue homeostasis by orchestrating M2 macrophage polarization via nuclear factor kappa B pathway.
Ding L, Liang Y, Wang Y, Tong Z, Liu W, Tan S, Zhang J, Wang Y, Wu Z, Liang X, Ma C, Gao L
Immunology 2023 Jan;168(1):49-62
Immunology 2023 Jan;168(1):49-62
Knockout of ICAT in Adipose Tissue Alleviates Fibro-inflammation in Obese Mice.
Song Z, Liu N, He Y, Chen J, Li J, Wang F, Wu Z
Inflammation 2023 Feb;46(1):404-417
Inflammation 2023 Feb;46(1):404-417
Increased BAT Thermogenesis in Male Mouse Apolipoprotein A4 Transgenic Mice.
LaRussa Z, Kuo HN, West K, Shen Z, Wisniewski K, Tso P, Coschigano KT, Lo CC
International journal of molecular sciences 2023 Feb 20;24(4)
International journal of molecular sciences 2023 Feb 20;24(4)
Lipopolysaccharide-induced persistent inflammation ameliorates fat accumulation by promoting adipose browning in vitro and in vivo.
Zhang W, Liu S, Kong L, Wu S, Zhong Z, Yu L, Yang Q, Zhang J, Li J, Zheng G
International journal of biological macromolecules 2023 Dec 1;252:126511
International journal of biological macromolecules 2023 Dec 1;252:126511
CCE and EODF as two distinct non-shivering thermogenesis models inducing weight loss.
Xu T, Wang J, Shi H, Wei X, Zhang H, Ji Y, Lu S, Yan Y, Yu X, Luo X, Wang H
Pflugers Archiv : European journal of physiology 2023 Aug;475(8):961-974
Pflugers Archiv : European journal of physiology 2023 Aug;475(8):961-974
Muscle-specific ER-associated degradation maintains postnatal muscle hypertrophy and systemic energy metabolism.
Abdon B, Liang Y, da Luz Scheffer D, Torres M, Shrestha N, Reinert RB, Lu Y, Pederson B, Bugarin-Lapuz A, Kersten S, Qi L
JCI insight 2023 Aug 3;8(17)
JCI insight 2023 Aug 3;8(17)
Interference of a mammalian circRNA regulates lipid metabolism reprogramming by targeting miR-24-3p/Igf2/PI3K-AKT-mTOR and Igf2bp2/Ucp1 axis.
Shao J, Wang M, Zhang A, Liu Z, Jiang G, Tang T, Wang J, Jia X, Lai S
Cellular and molecular life sciences : CMLS 2023 Aug 17;80(9):252
Cellular and molecular life sciences : CMLS 2023 Aug 17;80(9):252
Transcriptome-based selection and validation of optimal reference genes in perirenal adipose developing of goat (Capra hircus).
Zhao L, Yang H, Li X, Zhou Y, Liu T, Zhao Y
Frontiers in veterinary science 2022;9:1055866
Frontiers in veterinary science 2022;9:1055866
Comprehensive Analysis and Validation of Solute Carrier Family 25 (SLC25) and Its Correlation with Immune Infiltration in Pan-Cancer.
Liu AR, Liu YN, Shen SX, Yan LR, Lv Z, Ding HX, Wang A, Yuan Y, Xu Q
BioMed research international 2022;2022:4009354
BioMed research international 2022;2022:4009354
Ceiling culture of human mature white adipocytes with a browning agent: A novel approach to induce transdifferentiation into beige adipocytes.
He Y, Liang Z, Wang J, Tang H, Li J, Cai J, Liao Y
Frontiers in bioengineering and biotechnology 2022;10:905194
Frontiers in bioengineering and biotechnology 2022;10:905194
Naringenin activates beige adipocyte browning in high fat diet-fed C57BL/6 mice by shaping the gut microbiota.
Zhang S, Li J, Shi X, Tan X, Si Q
Food & function 2022 Oct 3;13(19):9918-9930
Food & function 2022 Oct 3;13(19):9918-9930
Artemisia sphaerocephala Krasch polysaccharide promotes adipose thermogenesis and decreases obesity by shaping the gut microbiota.
Zeng X, Ren D, Li D, Du H, Yang X
Food & function 2022 Oct 17;13(20):10651-10664
Food & function 2022 Oct 17;13(20):10651-10664
Irisin reduces the abnormal reproductive and metabolic phenotypes of PCOS by regulating the activity of brown adipose tissue in mice†.
Zheng Y, He J, Yang D, Yuan M, Liu S, Dai F, Jia Y, Cheng Y
Biology of reproduction 2022 Oct 11;107(4):1046-1058
Biology of reproduction 2022 Oct 11;107(4):1046-1058
A tumor-suppressive function for Notch3 in the parous mammary gland.
Chung WC, Egan SE, Xu K
Development (Cambridge, England) 2022 Oct 1;149(19)
Development (Cambridge, England) 2022 Oct 1;149(19)
Dysregulated adipose tissue expansion and impaired adipogenesis in Prader-Willi syndrome children before obesity-onset.
Chao Y, Gao L, Wang X, Cai Y, Shu Y, Zou X, Qin Y, Hu C, Dai Y, Zhu M, Shen Z, Zou C
Metabolism: clinical and experimental 2022 Nov;136:155295
Metabolism: clinical and experimental 2022 Nov;136:155295
Functional Attenuation of UCP1 as the Potential Mechanism for a Thickened Blubber Layer in Cetaceans.
Zhou M, Wu T, Chen Y, Xu S, Yang G
Molecular biology and evolution 2022 Nov 3;39(11)
Molecular biology and evolution 2022 Nov 3;39(11)
Adenosine-rich extract of Ganoderma lucidum: A safe and effective lipid-lowering substance.
Li H, Du Y, Ji H, Yang Y, Xu C, Li Q, Ran L, Wu C, Zhou Q, Wu S
iScience 2022 Nov 18;25(11):105214
iScience 2022 Nov 18;25(11):105214
Pu-erh tea increases the metabolite Cinnabarinic acid to improve circadian rhythm disorder-induced obesity.
Hu S, Hu C, Luo L, Zhang H, Zhao S, Liu Z, Zeng L
Food chemistry 2022 Nov 15;394:133500
Food chemistry 2022 Nov 15;394:133500
Lytic cocktail: An effective method to alleviate severe burn induced hyper-metabolism through regulating white adipose tissue browning.
Zhang M, Yang P, Yu T, Harmsen MC, Gao M, Liu D, Shi Y, Liu Y, Zhang X
Heliyon 2022 Mar;8(3):e09128
Heliyon 2022 Mar;8(3):e09128
Effects of maternal feed intake restriction on the blood parameters, fatty acid profile and lipogenetic genes expression of perirenal fat in offspring kids.
Chen W, Yang H, Yan Q, Zhou X, Tan Z, Wang Z
Animal reproduction science 2022 Mar;238:106955
Animal reproduction science 2022 Mar;238:106955
Knockdown of VEGFB/VEGFR1 Signaling Promotes White Adipose Tissue Browning and Skeletal Muscle Development.
Ling M, Lai X, Quan L, Li F, Lang L, Fu Y, Feng S, Yi X, Zhu C, Gao P, Zhu X, Wang L, Shu G, Jiang Q, Wang S
International journal of molecular sciences 2022 Jul 7;23(14)
International journal of molecular sciences 2022 Jul 7;23(14)
Parathyroid hormone-related protein prevents high-fat-diet-induced obesity, hepatic steatosis and insulin resistance in mice.
Qin B, Qincao L, He S, Liao Y, Shi J, Xie F, Diao N, Bai L
Endocrine journal 2022 Jan 28;69(1):55-65
Endocrine journal 2022 Jan 28;69(1):55-65
Dopamine receptor D1 signaling stimulates lipolysis and browning of white adipocytes.
Yu J, Zhu J, Deng J, Shen J, Du F, Wu X, Chen Y, Li M, Wen Q, Xiao Z, Zhao Y
Biochemical and biophysical research communications 2022 Jan 15;588:83-89
Biochemical and biophysical research communications 2022 Jan 15;588:83-89
Inhibition of high-fat diet-induced obesity via reduction of ER-resident protein Nogo occurs through multiple mechanisms.
Wang X, Yang Y, Zhao D, Zhang S, Chen Y, Chen Y, Feng K, Li X, Han J, Iwakiri Y, Duan Y, Yang X
The Journal of biological chemistry 2022 Feb;298(2):101561
The Journal of biological chemistry 2022 Feb;298(2):101561
Dietary succinate supplementation to maternal mice improves fetal brown adipose tissue development and thermogenesis of female offspring.
Liu X, Chen Y, Zhao L, Tian Q, deAvila JM, Zhu MJ, Du M
The Journal of nutritional biochemistry 2022 Feb;100:108908
The Journal of nutritional biochemistry 2022 Feb;100:108908
Quercetin, Engelitin and Caffeic Acid of Smilax china L. Polyphenols, Stimulate 3T3-L1 Adipocytes to Brown-like Adipocytes Via β3-AR/AMPK Signaling Pathway.
Kong L, Zhang W, Liu S, Zhong Z, Zheng G
Plant foods for human nutrition (Dordrecht, Netherlands) 2022 Dec;77(4):529-537
Plant foods for human nutrition (Dordrecht, Netherlands) 2022 Dec;77(4):529-537
miR-669a-5p promotes adipogenic differentiation and induces browning in preadipocytes.
Tan X, Zhu T, Zhang L, Fu L, Hu Y, Li H, Li C, Zhang J, Liang B, Liu J
Adipocyte 2022 Dec;11(1):120-132
Adipocyte 2022 Dec;11(1):120-132
Cold exposure prevents fat accumulation in striped hamsters refed a high-fat diet following food restriction.
Huo DL, Bao MH, Cao J, Zhao ZJ
BMC zoology 2022 Apr 18;7(1):19
BMC zoology 2022 Apr 18;7(1):19
Gold nanoclusters eliminate obesity induced by antipsychotics.
He M, Yao J, Zhang Z, Zhang Y, Chen R, Gu Z, Huang X, Deng C, Zhou R, Fan J, Zhang B, Xie Y, Gao G, Sun T
Scientific reports 2022 Apr 1;12(1):5502
Scientific reports 2022 Apr 1;12(1):5502
Transcription Factor E2F1 Knockout Promotes Mice White Adipose Tissue Browning Through Autophagy Inhibition.
Xiong M, Hu W, Tan Y, Yu H, Zhang Q, Zhao C, Yi Y, Wang Y, Wu Y, Wu M
Frontiers in physiology 2021;12:748040
Frontiers in physiology 2021;12:748040
Empagliflozin Induces White Adipocyte Browning and Modulates Mitochondrial Dynamics in KK Cg-Ay/J Mice and Mouse Adipocytes.
Xu L, Xu C, Liu X, Li X, Li T, Yu X, Xue M, Yang J, Kosmas CE, Moris D, Sanchis-Gomar F, Yoshida N, Berger NA, Aronow WS, Sun B, Chen L
Frontiers in physiology 2021;12:745058
Frontiers in physiology 2021;12:745058
DMRT2 Interacts With FXR and Improves Insulin Resistance in Adipocytes and a Mouse Model.
Tao J, Yu XL, Yuan YJ, Shen X, Liu J, Gu PP, Wang Z, Ma YT, Li GQ
Frontiers in endocrinology 2021;12:723623
Frontiers in endocrinology 2021;12:723623
Vitellogenin 2 promotes muscle development and stimulates the browning of white fat.
Li Y, Sun X, Bai Y, Ji Y, Ren H, Yu X, Yan Y, He X, Dong Y, Zhang L, Luo X, Wang H
Aging 2021 Oct 5;13(19):22985-23003
Aging 2021 Oct 5;13(19):22985-23003
Vitamin D/VDR regulates peripheral energy homeostasis via central renin-angiotensin system.
Su H, Liu N, Zhang Y, Kong J
Journal of advanced research 2021 Nov;33:69-80
Journal of advanced research 2021 Nov;33:69-80
Exposure to melamine cyanuric acid in adult mice induced thyroid dysfunction and circadian rhythm disorder.
Wang S, Wang S, Wang C, Feng D, Feng X
Ecotoxicology and environmental safety 2021 Nov 19;228:112992
Ecotoxicology and environmental safety 2021 Nov 19;228:112992
Aqueous extracts of Aconite promote thermogenesis in rats with hypothermia via regulating gut microbiota and bile acid metabolism.
Liu J, Tan Y, Ao H, Feng W, Peng C
Chinese medicine 2021 Mar 19;16(1):29
Chinese medicine 2021 Mar 19;16(1):29
Curcumin improves adipocytes browning and mitochondrial function in 3T3-L1 cells and obese rodent model.
Zhao D, Pan Y, Yu N, Bai Y, Ma R, Mo F, Zuo J, Chen B, Jia Q, Zhang D, Liu J, Jiang G, Gao S
Royal Society open science 2021 Mar 17;8(3):200974
Royal Society open science 2021 Mar 17;8(3):200974
A flavonoid-rich Smilax china L. extract prevents obesity by upregulating the adiponectin-receptor/AMPK signalling pathway and modulating the gut microbiota in mice.
Li X, Yang L, Li J, Lin L, Zheng G
Food & function 2021 Jul 5;12(13):5862-5875
Food & function 2021 Jul 5;12(13):5862-5875
Improvement of obesity-associated disorders by a small-molecule drug targeting mitochondria of adipose tissue macrophages.
Wang Y, Tang B, Long L, Luo P, Xiang W, Li X, Wang H, Jiang Q, Tan X, Luo S, Li H, Wang Z, Chen Z, Leng Y, Jiang Z, Wang Y, Ma L, Wang R, Zeng C, Liu Z, Wang Y, Miao H, Shi C
Nature communications 2021 Jan 4;12(1):102
Nature communications 2021 Jan 4;12(1):102
Skip participates in formation and lipid metabolism of beige adipose and might mediate the effects of SIRT1 activator BTM-0512 on beige remodeling.
Liao ZM, Li AN, Cai Y, Chen JJ, Xu Y, Sui LH, Wang JL, Jin P, Wang KS, Yang ZC
Biochemical and biophysical research communications 2021 Jan 22;537:109-117
Biochemical and biophysical research communications 2021 Jan 22;537:109-117
Nobiletin activates thermogenesis of brown and white adipose tissue in high-fat diet-fed C57BL/6 mice by shaping the gut microbiota.
Kou G, Li P, Hu Y, Chen H, Nyantakyiwaa Amoah A, Seydou Traore S, Cui Z, Lyu Q
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Feb;35(2):e21267
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Feb;35(2):e21267
Gentisic acid prevents diet-induced obesity in mice by accelerating the thermogenesis of brown adipose tissue.
Han X, Guo J, Gao Y, Zhan J, You Y, Huang W
Food & function 2021 Feb 15;12(3):1262-1270
Food & function 2021 Feb 15;12(3):1262-1270
Cbl Proto-Oncogene B (CBLB) c.197A>T Mutation Induces Mild Metabolic Dysfunction in Partial Type I Multiple Symmetric Lipomatosis (MSL).
Chen K, Wan X, Zhao L, Zhao S, Peng L, Yang W, Yuan J, Zhu L, Mo Z
Diabetes, metabolic syndrome and obesity : targets and therapy 2020;13:3535-3549
Diabetes, metabolic syndrome and obesity : targets and therapy 2020;13:3535-3549
Anti-Adipogenic Effect of Theabrownin Is Mediated by Bile Acid Alternative Synthesis via Gut Microbiota Remodeling.
Kuang J, Zheng X, Huang F, Wang S, Li M, Zhao M, Sang C, Ge K, Li Y, Li J, Rajani C, Ma X, Zhou S, Zhao A, Jia W
Metabolites 2020 Nov 23;10(11)
Metabolites 2020 Nov 23;10(11)
A dysregulated bile acid-gut microbiota axis contributes to obesity susceptibility.
Wei M, Huang F, Zhao L, Zhang Y, Yang W, Wang S, Li M, Han X, Ge K, Qu C, Rajani C, Xie G, Zheng X, Zhao A, Bian Z, Jia W
EBioMedicine 2020 May;55:102766
EBioMedicine 2020 May;55:102766
Supplementation with Extracellular Vesicles Derived from Adipose-Derived Stem Cells Increases Fat Graft Survival and Browning in Mice: A Cell-Free Approach to Construct Beige Fat from White Fat Grafting.
Zhu YZ, Zhang J, Hu X, Wang ZH, Wu S, Yi YY
Plastic and reconstructive surgery 2020 May;145(5):1183-1195
Plastic and reconstructive surgery 2020 May;145(5):1183-1195
ChREBP-β regulates thermogenesis in brown adipose tissue.
Wei C, Ma X, Su K, Qi S, Zhu Y, Lin J, Wang C, Yang R, Chen X, Wang W, Zhang WJ
The Journal of endocrinology 2020 Jun;245(3):343-356
The Journal of endocrinology 2020 Jun;245(3):343-356
TSH promotes adiposity by inhibiting the browning of white fat.
Zhang J, Wu H, Ma S, Gao L, Yu C, Jing F, Zhao J
Adipocyte 2020 Dec;9(1):264-278
Adipocyte 2020 Dec;9(1):264-278
Feeding induces cholesterol biosynthesis via the mTORC1-USP20-HMGCR axis.
Lu XY, Shi XJ, Hu A, Wang JQ, Ding Y, Jiang W, Sun M, Zhao X, Luo J, Qi W, Song BL
Nature 2020 Dec;588(7838):479-484
Nature 2020 Dec;588(7838):479-484
p66Shc Contributes to Liver Fibrosis through the Regulation of Mitochondrial Reactive Oxygen Species.
Zhao Y, Wang Z, Feng D, Zhao H, Lin M, Hu Y, Zhang N, Lv L, Gao Z, Zhai X, Tian X, Yao J
Theranostics 2019;9(5):1510-1522
Theranostics 2019;9(5):1510-1522
Lipid Profiling Reveals Browning Heterogeneity of White Adipose Tissue by Β3-Adrenergic Stimulation.
He P, Hou B, Li Y, Xu C, Ma P, Lam SM, Gil V, Yang X, Yang X, Zhang L, Shui G, Song J, Qiang G, Liew CW, Du G
Biomolecules 2019 Sep 3;9(9)
Biomolecules 2019 Sep 3;9(9)
Metabolic and endocrinal effects of N-desmethyl-olanzapine in mice with obesity: Implication for olanzapine-associated metabolic changes.
Zhang X, Zhao Y, Shao H, Zheng X
Psychoneuroendocrinology 2019 Oct;108:163-171
Psychoneuroendocrinology 2019 Oct;108:163-171
Regulating glycolysis, the TLR4 signal pathway and expression of RBM3 in mouse liver in response to acute cold exposure.
Shi H, Yao R, Lian S, Liu P, Liu Y, Yang YY, Yang H, Li S
Stress (Amsterdam, Netherlands) 2019 May;22(3):366-376
Stress (Amsterdam, Netherlands) 2019 May;22(3):366-376
Gpnmb secreted from liver promotes lipogenesis in white adipose tissue and aggravates obesity and insulin resistance.
Gong XM, Li YF, Luo J, Wang JQ, Wei J, Wang JQ, Xiao T, Xie C, Hong J, Ning G, Shi XJ, Li BL, Qi W, Song BL
Nature metabolism 2019 May;1(5):570-583
Nature metabolism 2019 May;1(5):570-583
Deficiency of heat shock protein A12A promotes browning of white adipose tissues in mice.
Cheng H, Qi T, Zhang X, Kong Q, Min X, Mao Q, Cao X, Liu L, Ding Z
Biochimica et biophysica acta. Molecular basis of disease 2019 Jun 1;1865(6):1451-1459
Biochimica et biophysica acta. Molecular basis of disease 2019 Jun 1;1865(6):1451-1459
Gdf11 gene transfer prevents high fat diet-induced obesity and improves metabolic homeostasis in obese and STZ-induced diabetic mice.
Lu B, Zhong J, Pan J, Yuan X, Ren M, Jiang L, Yang Y, Zhang G, Liu D, Zhang C
Journal of translational medicine 2019 Dec 17;17(1):422
Journal of translational medicine 2019 Dec 17;17(1):422
Identification of a natural beige adipose depot in mice.
Chan M, Lim YC, Yang J, Namwanje M, Liu L, Qiang L
The Journal of biological chemistry 2019 Apr 26;294(17):6751-6761
The Journal of biological chemistry 2019 Apr 26;294(17):6751-6761
Zinc-α2-Glycoprotein Is Associated with Obesity in Chinese People and HFD-Induced Obese Mice.
Liu M, Zhu H, Dai Y, Pan H, Li N, Wang L, Yang H, Yan K, Gong F
Frontiers in physiology 2018;9:62
Frontiers in physiology 2018;9:62
The Protective Effects of Danggui-Baizhu-Tang on High-Fat Diet-Induced Obesity in Mice by Activating Thermogenesis.
Zhao L, Zhu X, Cong R, Yang X, Zhu Y
Frontiers in pharmacology 2018;9:1019
Frontiers in pharmacology 2018;9:1019
Renoprotective Effect of Danhong Injection on Streptozotocin-Induced Diabetic Rats through a Peroxisome Proliferator-Activated Receptor γ Mediated Pathway.
Yang X, Xiao X, Wang H, Li Y, Wang L, Li G, Deng S
Evidence-based complementary and alternative medicine : eCAM 2018;2018:3450141
Evidence-based complementary and alternative medicine : eCAM 2018;2018:3450141
Exosomes From Adipose-Derived Stem Cells Attenuate Adipose Inflammation and Obesity Through Polarizing M2 Macrophages and Beiging in White Adipose Tissue.
Zhao H, Shang Q, Pan Z, Bai Y, Li Z, Zhang H, Zhang Q, Guo C, Zhang L, Wang Q
Diabetes 2018 Feb;67(2):235-247
Diabetes 2018 Feb;67(2):235-247
Antiobesity effect of Lactobacillus reuteri 263 associated with energy metabolism remodeling of white adipose tissue in high-energy-diet-fed rats.
Chen LH, Chen YH, Cheng KC, Chien TY, Chan CH, Tsao SP, Huang HY
The Journal of nutritional biochemistry 2018 Apr;54:87-94
The Journal of nutritional biochemistry 2018 Apr;54:87-94
Green tea extract induces genes related to browning of white adipose tissue and limits weight-gain in high energy diet-fed rat.
Chen LH, Chien YW, Liang CT, Chan CH, Fan MH, Huang HY
Food & nutrition research 2017;61(1):1347480
Food & nutrition research 2017;61(1):1347480
Pdcd4 restrains the self-renewal and white-to-beige transdifferentiation of adipose-derived stem cells.
Bai Y, Shang Q, Zhao H, Pan Z, Guo C, Zhang L, Wang Q
Cell death & disease 2016 Mar 31;7(3):e2169
Cell death & disease 2016 Mar 31;7(3):e2169
Liraglutide suppresses obesity and induces brown fat-like phenotype via Soluble Guanylyl Cyclase mediated pathway in vivo and in vitro.
Zhu E, Yang Y, Zhang J, Li Y, Li C, Chen L, Sun B
Oncotarget 2016 Dec 6;7(49):81077-81089
Oncotarget 2016 Dec 6;7(49):81077-81089
Programmed cell death-4 deficiency prevents diet-induced obesity, adipose tissue inflammation, and insulin resistance.
Wang Q, Dong Z, Liu X, Song X, Song Q, Shang Q, Jiang Y, Guo C, Zhang L
Diabetes 2013 Dec;62(12):4132-43
Diabetes 2013 Dec;62(12):4132-43
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Gong FY, Zhang SJ, Deng JY, Zhu HJ, Pan H, Li NS, Shi YF
International journal of obesity (2005) 2009 Sep;33(9):1023-30
International journal of obesity (2005) 2009 Sep;33(9):1023-30
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse brown adipose tissue were subjected to SDS PAGE followed by western blot with 23673-1-AP( UCP1 antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded rat brain using 23673-1-AP( UCP1 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The UCP1 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human UCP1. This antibody recognizes human, mouse antigen. The UCP1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
