TMX1

This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and one transmembrane domain. Unlike most members of this gene family, it lacks a C-terminal ER-retention sequence. The mature membrane-bound protein can both oxidize and reduce disulfide bonds and acts selectively on membrane-associated polypeptides. [provided by RefSeq, Jan 2017]

Description

Thioredoxin related transmembrane protein 1

Tissue specificity

Low tissue specificity

Subcell location

Nucleoli, Endoplasmic reticulum

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transporters

Chromosome

14 (51240162 - 51257655)

Ensembl ID

ENSG00000139921  (ver. 103.38)

Orthologs

Mouse Tmx1: ENSMUSG00000021072

UniProt

Q9H3N1

neXtProt

NX_Q9H3N1

Human splice variants
Mouse splice variants

Protein structure