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Flow cytometryAntibody data
- Antibody Data
- Antigen structure
- References [3]
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- Validations
- Flow cytometry [1]
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- Product number
- 14-5979-82 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- CD272 (BTLA) Monoclonal Antibody (MIH26), eBioscience™
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- Description: The BTLA monoclonal antibody reacts with human B and T lymphocyte attenuator (BTLA). BTLA is expressed by peripheral lymphocytes, splenic macrophages, developing B cells in the bone marrow and developing T cells in the thymus and mature, but not immature bone marrow-derived dendritic cells. BTLA is implicated as a negative regulator of the activation and/or function of various hemopoietic cell types. It is reported that BTLA binds to B7-H4, but further studies are needed to confirm this interaction.
- Antibody clone number
- MIH26
- Concentration
- 0.5 mg/mL
Submitted references A functional polymorphism in B and T lymphocyte attenuator is associated with susceptibility to rheumatoid arthritis.
B and T lymphocyte attenuator down-regulation by HIV-1 depends on type I interferon and contributes to T-cell hyperactivation.
BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1.
Oki M, Watanabe N, Owada T, Oya Y, Ikeda K, Saito Y, Matsumura R, Seto Y, Iwamoto I, Nakajima H
Clinical & developmental immunology 2011;2011:305656
Clinical & developmental immunology 2011;2011:305656
B and T lymphocyte attenuator down-regulation by HIV-1 depends on type I interferon and contributes to T-cell hyperactivation.
Zhang Z, Xu X, Lu J, Zhang S, Gu L, Fu J, Jin L, Li H, Zhao M, Zhang J, Wu H, Su L, Fu YX, Wang FS
The Journal of infectious diseases 2011 Jun 1;203(11):1668-78
The Journal of infectious diseases 2011 Jun 1;203(11):1668-78
BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1.
Watanabe N, Gavrieli M, Sedy JR, Yang J, Fallarino F, Loftin SK, Hurchla MA, Zimmerman N, Sim J, Zang X, Murphy TL, Russell JH, Allison JP, Murphy KM
Nature immunology 2003 Jul;4(7):670-9
Nature immunology 2003 Jul;4(7):670-9
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Supportive validation
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- Invitrogen Antibodies (provider)
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- Experimental details
- Staining of normal human peripheral blood cells with 0.25 µg of Mouse IgG2a kappa Isotype Control Purified (Product # 14-4724-82) (open histogram) or 0.25 µg of Anti-Human CD272 (BTLA) Purified (filled histogram) followed by Anti-Mouse IgG FITC (Product # 11-4011-85). Cells in the lymphocyte gate were used for analysis.
