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- Antigen structure
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- Product number
- 60303-1-Ig - Provider product page
- Provider
- Proteintech Group
- Product name
- SIRT1 antibody
- Antibody type
- Monoclonal
- Description
- KD/KO validated SIRT1 antibody (Cat. #60303-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 7F6G6
- Vial size
- 20ul, 150ul
Submitted references Fucoxanthin ameliorates endoplasmic reticulum stress and inhibits apoptosis and alleviates intervertebral disc degeneration in rats by upregulating Sirt1.
Electroacupuncture improves cognitive function in a rat model of mild traumatic brain injury by regulating the SIRT-1/PGC-1α/mitochondrial pathway.
Resveratrol attenuates cyclosporin A-induced upregulation of the thromboxane A(2) receptor and hypertension via the AMPK/SIRT1 and MAPK/NF-κB pathways in the rat mesenteric artery.
Sirt1 inhibits macrophage polarization and inflammation in gouty arthritis by inhibiting the MAPK/NF-κB/AP-1 pathway and activating the Nrf2/HO-1 pathway.
High-fat diet induces cognitive impairment through repression of SIRT1/AMPK-mediated autophagy.
Metformin protects ovarian granulosa cells in chemotherapy-induced premature ovarian failure mice through AMPK/PPAR-γ/SIRT1 pathway.
Nicotinamide mononucleotide pretreatment improves long-term isoflurane anesthesia-induced cognitive impairment in mice.
The use of a systems approach to increase NAD(+) in human participants.
Pyrroloquinoline quinone promotes human mesenchymal stem cell-derived mitochondria to improve premature ovarian insufficiency in mice through the SIRT1/ATM/p53 pathway.
Nobiletin enhances mitochondrial function by regulating SIRT1/PGC-1α signaling in porcine oocytes during in vitro maturation.
Resveratrol Improves the Progression of Osteoarthritis by Regulating the SIRT1-FoxO1 Pathway-Mediated Cholesterol Metabolism.
Protectin DX Relieve Hyperoxia-induced Lung Injury by Protecting Pulmonary Endothelial Glycocalyx.
Eldecalcitol prevented OVX-induced osteoporosis through inhibiting BMSCs senescence by regulating the SIRT1-Nrf2 signal.
Knockdown of Y-box binding protein 1 induces autophagy in early porcine embryos.
Menaquinone-4 prevents medication-related osteonecrosis of the jaw through the SIRT1 signaling-mediated inhibition of cellular metabolic stresses-induced osteoblast apoptosis.
Investigation of the potential ameliorative effects of DHA-enriched phosphatidylserine on bisphenol A-induced murine nephrotoxicity.
Muscle PARP1 inhibition extends lifespan through AMPKα PARylation and activation in Drosophila.
HypERlnc attenuates angiotensin II-induced cardiomyocyte hypertrophy via promoting SIRT1 SUMOylation-mediated activation of PGC-1α/PPARα pathway in AC16 cells.
Glycolytic reprogramming controls periodontitis-associated macrophage pyroptosis via AMPK/SIRT1/NF-κB signaling pathway.
Y-box binding protein 1 influences zygotic genome activation by regulating N6-methyladenosine in porcine embryos.
Modulatory effect of n-3 polyunsaturated fatty acids on depressive-like behaviors in rats with chronic sleep deprivation: potential involvement of melatonin receptor pathway and brain lipidome.
Long non-coding RNA HOXC-AS1 exerts its oncogenic effects in esophageal squamous cell carcinoma by interaction with IGF2BP2 to stabilize SIRT1 expression.
Dietary selenium excess affected spermatogenesis via DNA damage and telomere-related cell senescence and apoptosis in mice.
Fyn deficiency inhibits oxidative stress by decreasing c-Cbl-mediated ubiquitination of Sirt1 to attenuate diabetic renal fibrosis.
GRP78 acts as a cAMP/PKA signaling modulator through the MC4R pathway in porcine embryonic development.
Resveratrol improves follicular development of PCOS rats via regulating glycolysis pathway and targeting SIRT1.
An Energy Metabolism Study on the Efficacy of Naoxintong Capsules against Myocardial Infarction in a Rat Model.
Mesenchymal Stem Cell-Derived Exosomes Ameliorate Delayed Neurocognitive Recovery in Aged Mice by Inhibiting Hippocampus Ferroptosis via Activating SIRT1/Nrf2/HO-1 Signaling Pathway.
Rotenone causes mitochondrial dysfunction and prevents maturation in porcine oocytes.
Sirtuin Type 1 Mediates the Antidepressant Effect of S-Ketamine in a Chronic Unpredictable Stress Model.
Protocatechualdehyde Rescues Oxygen-Glucose Deprivation/Reoxygenation-Induced Endothelial Cells Injury by Inducing Autophagy and Inhibiting Apoptosis via Regulation of SIRT1.
Curcumol alleviates liver fibrosis by inducing endoplasmic reticulum stress-mediated necroptosis of hepatic stellate cells through Sirt1/NICD pathway.
Resveratrol protection against IL-1β-induced chondrocyte damage via the SIRT1/FOXO1 signaling pathway.
SIRT1/mTOR pathway-mediated autophagy dysregulation promotes Pb-induced hepatic lipid accumulation in HepG2 cells.
Modification of lysine deacetylation regulates curcumol-induced necroptosis through autophagy in hepatic stellate cells.
Curcumin attenuates isoniazid-induced hepatotoxicity by upregulating the SIRT1/PGC-1α/NRF1 pathway.
Berberine exerts protective effects on cardiac senescence by regulating the Klotho/SIRT1 signaling pathway.
COX-2/sEH Dual Inhibitor Alleviates Hepatocyte Senescence in NAFLD Mice by Restoring Autophagy through Sirt1/PI3K/AKT/mTOR.
Phenylalanine impairs insulin signaling and inhibits glucose uptake through modification of IRβ.
Exposure to Bisphenol A Caused Hepatoxicity and Intestinal Flora Disorder in Rats.
Resveratrol Improves Synaptic Plasticity in Hypoxic-Ischemic Brain Injury in Neonatal Mice via Alleviating SIRT1/NF-κB Signaling-Mediated Neuroinflammation.
G0S2 ameliorates oxidized low-density lipoprotein-induced vascular endothelial cell injury by regulating mitochondrial apoptosis.
The vesicular transporter STX11 governs ATGL-mediated hepatic lipolysis and lipophagy.
Ginsenoside CK Inhibits TGF-β-Induced Epithelial-Mesenchymal Transition in A549 Cell via SIRT1.
miR-539 Targeting SNAI2 Regulates MMP9 Signaling Pathway and Affects Blood-Brain Barrier Permeability in Cerebrovascular Occlusive Diseases: A Study Based on Head and Neck Ultrasound and CTA.
Acetyl-CoA synthases are essential for maintaining histone acetylation under metabolic stress during zygotic genome activation in pigs.
Aronia melanocarpa polysaccharide ameliorates inflammation and aging in mice by modulating the AMPK/SIRT1/NF-κB signaling pathway and gut microbiota.
Maternally expressed 3 protects the intestinal barrier from cardiac arrest-induced ischemia/reperfusion injury via miR-34a-3p/sirtuin 1/nuclear factor kappa B signaling.
Endurance Exercise-Induced Autophagy/Mitophagy Coincides with a Reinforced Anabolic State and Increased Mitochondrial Turnover in the Cortex of Young Male Mouse Brain.
Melatonin protects mouse testes from palmitic acid-induced lipotoxicity by attenuating oxidative stress and DNA damage in a SIRT1-dependent manner.
Resveratrol Attenuates Aortic Dissection by Increasing Endothelial Barrier Function Through the SIRT1 Pathway.
Ameliorative effects and mechanism of crocetin in arsenic trioxide‑induced cardiotoxicity in rats.
TP53 mutation influences the efficacy of treatment of colorectal cancer cell lines with a combination of sirtuin inhibitors and chemotherapeutic agents.
Catalytic-independent neuroprotection by SIRT1 is mediated through interaction with HDAC1.
SIRT1 protects against urban particulate matter-induced airway inflammation.
SIRT1-regulated HMGB1 release is partially involved in TLR4 signal transduction: A possible anti-neuroinflammatory mechanism of resveratrol in neonatal hypoxic-ischemic brain injury.
Microglia Activated by Excess Cortisol Induce HMGB1 Acetylation and Neuroinflammation in the Hippocampal DG Region of Mice Following Cold Exposure.
Teng C, Wu J, Zhang Z, Wang J, Yang Y, Dong C, Wu L, Lin Z, Hu Y, Wang J, Zhang X, Lin Z
Phytotherapy research : PTR 2024 May;38(5):2114-2127
Phytotherapy research : PTR 2024 May;38(5):2114-2127
Electroacupuncture improves cognitive function in a rat model of mild traumatic brain injury by regulating the SIRT-1/PGC-1α/mitochondrial pathway.
Jin B, Gao Y, Fu Y, Zhang S, Zhang K, Su Y
Chinese medical journal 2024 Mar 20;137(6):711-719
Chinese medical journal 2024 Mar 20;137(6):711-719
Resveratrol attenuates cyclosporin A-induced upregulation of the thromboxane A(2) receptor and hypertension via the AMPK/SIRT1 and MAPK/NF-κB pathways in the rat mesenteric artery.
Li Q, Cao H, Xu X, Chen Y, Zhang Y, Mi Y, Zhu X, Shi Y, Liu J, Wang B, Xu CB, Wang C
European journal of pharmacology 2024 Jun 5;972:176543
European journal of pharmacology 2024 Jun 5;972:176543
Sirt1 inhibits macrophage polarization and inflammation in gouty arthritis by inhibiting the MAPK/NF-κB/AP-1 pathway and activating the Nrf2/HO-1 pathway.
Zhao X, Li M, Lu Y, Wang M, Xiao J, Xie Q, He X, Shuai S
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2024 Jul;73(7):1173-1184
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2024 Jul;73(7):1173-1184
High-fat diet induces cognitive impairment through repression of SIRT1/AMPK-mediated autophagy.
Yi W, Chen F, Yuan M, Wang C, Wang S, Wen J, Zou Q, Pu Y, Cai Z
Experimental neurology 2024 Jan;371:114591
Experimental neurology 2024 Jan;371:114591
Metformin protects ovarian granulosa cells in chemotherapy-induced premature ovarian failure mice through AMPK/PPAR-γ/SIRT1 pathway.
Yang Y, Tang X, Yao T, Zhang Y, Zhong Y, Wu S, Wang Y, Pan Z
Scientific reports 2024 Jan 16;14(1):1447
Scientific reports 2024 Jan 16;14(1):1447
Nicotinamide mononucleotide pretreatment improves long-term isoflurane anesthesia-induced cognitive impairment in mice.
Xu J, Chen X, Liu S, Wei Z, Xu M, Jiang L, Han X, Peng L, Gu X, Xia T
Behavioural brain research 2024 Feb 26;458:114738
Behavioural brain research 2024 Feb 26;458:114738
The use of a systems approach to increase NAD(+) in human participants.
Henderson JD, Quigley SNZ, Chachra SS, Conlon N, Ford D
npj aging 2024 Feb 1;10(1):7
npj aging 2024 Feb 1;10(1):7
Pyrroloquinoline quinone promotes human mesenchymal stem cell-derived mitochondria to improve premature ovarian insufficiency in mice through the SIRT1/ATM/p53 pathway.
Liu S, Wang Y, Yang H, Tan J, Zhang J, Zi D
Stem cell research & therapy 2024 Apr 5;15(1):97
Stem cell research & therapy 2024 Apr 5;15(1):97
Nobiletin enhances mitochondrial function by regulating SIRT1/PGC-1α signaling in porcine oocytes during in vitro maturation.
Lee SH, Li XH, Lu QY, Zhan CL, Kim JD, Lee GH, Sim JM, Cui XS
Biochemical and biophysical research communications 2024 Apr 30;706:149747
Biochemical and biophysical research communications 2024 Apr 30;706:149747
Resveratrol Improves the Progression of Osteoarthritis by Regulating the SIRT1-FoxO1 Pathway-Mediated Cholesterol Metabolism.
Liang C, Xing H, Wang C, Xu X, Hao Y, Qiu B
Mediators of inflammation 2023;2023:2936236
Mediators of inflammation 2023;2023:2936236
Protectin DX Relieve Hyperoxia-induced Lung Injury by Protecting Pulmonary Endothelial Glycocalyx.
Liang Z, Yue H, Xu C, Wang Q, Jin S
Journal of inflammation research 2023;16:421-431
Journal of inflammation research 2023;16:421-431
Eldecalcitol prevented OVX-induced osteoporosis through inhibiting BMSCs senescence by regulating the SIRT1-Nrf2 signal.
Kou Y, Rong X, Tang R, Zhang Y, Yang P, Liu H, Ma W, Li M
Frontiers in pharmacology 2023;14:1067085
Frontiers in pharmacology 2023;14:1067085
Knockdown of Y-box binding protein 1 induces autophagy in early porcine embryos.
Jiang WJ, Lee SH, Heo G, Chung HJ, Cho ES, Sa SJ, Hochi S, Cui XS
Frontiers in cell and developmental biology 2023;11:1238546
Frontiers in cell and developmental biology 2023;11:1238546
Menaquinone-4 prevents medication-related osteonecrosis of the jaw through the SIRT1 signaling-mediated inhibition of cellular metabolic stresses-induced osteoblast apoptosis.
Cui Y, Zhang W, Yang P, Zhu S, Luo S, Li M
Free radical biology & medicine 2023 Sep;206:33-49
Free radical biology & medicine 2023 Sep;206:33-49
Investigation of the potential ameliorative effects of DHA-enriched phosphatidylserine on bisphenol A-induced murine nephrotoxicity.
Pu Q, Yang F, Zhao R, Jiang S, Tang Y, Han T
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Oct;180:114012
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Oct;180:114012
Muscle PARP1 inhibition extends lifespan through AMPKα PARylation and activation in Drosophila.
Guo S, Zhang S, Zhuang Y, Xie F, Wang R, Kong X, Zhang Q, Feng Y, Gao H, Kong X, Liu T
Proceedings of the National Academy of Sciences of the United States of America 2023 Mar 28;120(13):e2213857120
Proceedings of the National Academy of Sciences of the United States of America 2023 Mar 28;120(13):e2213857120
HypERlnc attenuates angiotensin II-induced cardiomyocyte hypertrophy via promoting SIRT1 SUMOylation-mediated activation of PGC-1α/PPARα pathway in AC16 cells.
Yue L, Sheng S, Yuan M, Lu J, Li T, Shi Y, Dong Z
Cell biology international 2023 Jun;47(6):1068-1080
Cell biology international 2023 Jun;47(6):1068-1080
Glycolytic reprogramming controls periodontitis-associated macrophage pyroptosis via AMPK/SIRT1/NF-κB signaling pathway.
He Y, Wang Y, Jia X, Li Y, Yang Y, Pan L, Zhao R, Han Y, Wang F, Guan X, Hou T
International immunopharmacology 2023 Jun;119:110192
International immunopharmacology 2023 Jun;119:110192
Y-box binding protein 1 influences zygotic genome activation by regulating N6-methyladenosine in porcine embryos.
Jiang WJ, Sun MH, Li XH, Lee SH, Heo G, Zhou D, Cui XS
Journal of cellular physiology 2023 Jul;238(7):1592-1604
Journal of cellular physiology 2023 Jul;238(7):1592-1604
Modulatory effect of n-3 polyunsaturated fatty acids on depressive-like behaviors in rats with chronic sleep deprivation: potential involvement of melatonin receptor pathway and brain lipidome.
Chang CH, Wu HC, Hsieh YR, Lai WD, Tung TH, Huang JJ, Kao WY, Huang SY
Food & function 2023 Jul 3;14(13):5977-5993
Food & function 2023 Jul 3;14(13):5977-5993
Long non-coding RNA HOXC-AS1 exerts its oncogenic effects in esophageal squamous cell carcinoma by interaction with IGF2BP2 to stabilize SIRT1 expression.
Yang Z, Wan J, Ma L, Li Z, Yang R, Yang H, Li J, Zhou F, Ming L
Journal of clinical laboratory analysis 2023 Jan;37(1):e24801
Journal of clinical laboratory analysis 2023 Jan;37(1):e24801
Dietary selenium excess affected spermatogenesis via DNA damage and telomere-related cell senescence and apoptosis in mice.
Zhang Y, Liu J, Li X, Zhou G, Sang Y, Zhang M, Gao L, Xue J, Zhao M, Yu H, Zhou X
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jan;171:113556
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jan;171:113556
Fyn deficiency inhibits oxidative stress by decreasing c-Cbl-mediated ubiquitination of Sirt1 to attenuate diabetic renal fibrosis.
Li S, Lin Z, Xiao H, Xu Z, Li C, Zeng J, Xie X, Deng L, Huang H
Metabolism: clinical and experimental 2023 Feb;139:155378
Metabolism: clinical and experimental 2023 Feb;139:155378
GRP78 acts as a cAMP/PKA signaling modulator through the MC4R pathway in porcine embryonic development.
Heo G, Lee SH, Kim JD, Lee GH, Sim JM, Zhou D, Guo J, Cui XS
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Dec;37(12):e23274
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Dec;37(12):e23274
Resveratrol improves follicular development of PCOS rats via regulating glycolysis pathway and targeting SIRT1.
Huo P, Li M, Le J, Zhu C, Yao J, Zhang S
Systems biology in reproductive medicine 2023 Apr;69(2):153-165
Systems biology in reproductive medicine 2023 Apr;69(2):153-165
An Energy Metabolism Study on the Efficacy of Naoxintong Capsules against Myocardial Infarction in a Rat Model.
Zhao J, Ouyang Y, Wang H, Lai H, Hu S, Tang L, Yang H, Wu H
Oxidative medicine and cellular longevity 2022;2022:3712500
Oxidative medicine and cellular longevity 2022;2022:3712500
Mesenchymal Stem Cell-Derived Exosomes Ameliorate Delayed Neurocognitive Recovery in Aged Mice by Inhibiting Hippocampus Ferroptosis via Activating SIRT1/Nrf2/HO-1 Signaling Pathway.
Liu J, Huang J, Zhang Z, Zhang R, Sun Q, Zhang Z, Liu Y, Ma B
Oxidative medicine and cellular longevity 2022;2022:3593294
Oxidative medicine and cellular longevity 2022;2022:3593294
Rotenone causes mitochondrial dysfunction and prevents maturation in porcine oocytes.
Heo G, Sun MH, Jiang WJ, Li XH, Lee SH, Guo J, Zhou D, Cui XS
PloS one 2022;17(11):e0277477
PloS one 2022;17(11):e0277477
Sirtuin Type 1 Mediates the Antidepressant Effect of S-Ketamine in a Chronic Unpredictable Stress Model.
Hou L, Miao J, Meng H, Liu X, Wang D, Tan Y, Li C
Frontiers in psychiatry 2022;13:855810
Frontiers in psychiatry 2022;13:855810
Protocatechualdehyde Rescues Oxygen-Glucose Deprivation/Reoxygenation-Induced Endothelial Cells Injury by Inducing Autophagy and Inhibiting Apoptosis via Regulation of SIRT1.
Cao S, Chen S, Qiao X, Guo Y, Liu F, Ding Z, Jin B
Frontiers in pharmacology 2022;13:846513
Frontiers in pharmacology 2022;13:846513
Curcumol alleviates liver fibrosis by inducing endoplasmic reticulum stress-mediated necroptosis of hepatic stellate cells through Sirt1/NICD pathway.
Sun S, Huan S, Li Z, Yao Y, Su Y, Xia S, Wang S, Xu X, Shao J, Zhang Z, Zhang F, Fu J, Zheng S
PeerJ 2022;10:e13376
PeerJ 2022;10:e13376
Resveratrol protection against IL-1β-induced chondrocyte damage via the SIRT1/FOXO1 signaling pathway.
Liang C, Xing H, Wang C, Xu X, Hao Y, Qiu B
Journal of orthopaedic surgery and research 2022 Sep 5;17(1):406
Journal of orthopaedic surgery and research 2022 Sep 5;17(1):406
SIRT1/mTOR pathway-mediated autophagy dysregulation promotes Pb-induced hepatic lipid accumulation in HepG2 cells.
Zhao Y, Mao A, Zhang R, Guan S, Lu J
Environmental toxicology 2022 Mar;37(3):549-563
Environmental toxicology 2022 Mar;37(3):549-563
Modification of lysine deacetylation regulates curcumol-induced necroptosis through autophagy in hepatic stellate cells.
Sun S, Li Z, Huan S, Kai J, Xia S, Su Y, Ji S, Chen A, Wang S, Xu X, Shao J, Zhang F, Zhang B, Zhang Z, Zheng S
Phytotherapy research : PTR 2022 Jun;36(6):2660-2676
Phytotherapy research : PTR 2022 Jun;36(6):2660-2676
Curcumin attenuates isoniazid-induced hepatotoxicity by upregulating the SIRT1/PGC-1α/NRF1 pathway.
Li Y, Luo WW, Cheng X, Xiang HR, He B, Zhang QZ, Peng WX
Journal of applied toxicology : JAT 2022 Jul;42(7):1192-1204
Journal of applied toxicology : JAT 2022 Jul;42(7):1192-1204
Berberine exerts protective effects on cardiac senescence by regulating the Klotho/SIRT1 signaling pathway.
Li C, Jiang S, Wang H, Wang Y, Han Y, Jiang J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Jul;151:113097
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Jul;151:113097
COX-2/sEH Dual Inhibitor Alleviates Hepatocyte Senescence in NAFLD Mice by Restoring Autophagy through Sirt1/PI3K/AKT/mTOR.
Zhang CY, Tan XH, Yang HH, Jin L, Hong JR, Zhou Y, Huang XT
International journal of molecular sciences 2022 Jul 27;23(15)
International journal of molecular sciences 2022 Jul 27;23(15)
Phenylalanine impairs insulin signaling and inhibits glucose uptake through modification of IRβ.
Zhou Q, Sun WW, Chen JC, Zhang HL, Liu J, Lin Y, Lin PC, Wu BX, An YP, Huang L, Sun WX, Zhou XW, Li YM, Yuan YY, Zhao JY, Xu W, Zhao SM
Nature communications 2022 Jul 25;13(1):4291
Nature communications 2022 Jul 25;13(1):4291
Exposure to Bisphenol A Caused Hepatoxicity and Intestinal Flora Disorder in Rats.
Liu R, Liu B, Tian L, Jiang X, Li X, Cai D, Sun J, Bai W, Jin Y
International journal of molecular sciences 2022 Jul 21;23(14)
International journal of molecular sciences 2022 Jul 21;23(14)
Resveratrol Improves Synaptic Plasticity in Hypoxic-Ischemic Brain Injury in Neonatal Mice via Alleviating SIRT1/NF-κB Signaling-Mediated Neuroinflammation.
Peng X, Wang J, Peng J, Jiang H, Le K
Journal of molecular neuroscience : MN 2022 Jan;72(1):113-125
Journal of molecular neuroscience : MN 2022 Jan;72(1):113-125
G0S2 ameliorates oxidized low-density lipoprotein-induced vascular endothelial cell injury by regulating mitochondrial apoptosis.
Liang Z, Diao W, Jiang Y, Zhang Y
Annals of translational medicine 2022 Dec;10(24):1383
Annals of translational medicine 2022 Dec;10(24):1383
The vesicular transporter STX11 governs ATGL-mediated hepatic lipolysis and lipophagy.
Zhang G, Han J, Wang L, Yang X, Yan Z, Qu M, Zhou H, Bilal H, Wang F, Ge H, Yang X
iScience 2022 Apr 15;25(4):104085
iScience 2022 Apr 15;25(4):104085
Ginsenoside CK Inhibits TGF-β-Induced Epithelial-Mesenchymal Transition in A549 Cell via SIRT1.
Sun M, Zhuang X, Lv G, Lin Z, Huang X, Zhao J, Lin H, Wang Y
BioMed research international 2021;2021:9140191
BioMed research international 2021;2021:9140191
miR-539 Targeting SNAI2 Regulates MMP9 Signaling Pathway and Affects Blood-Brain Barrier Permeability in Cerebrovascular Occlusive Diseases: A Study Based on Head and Neck Ultrasound and CTA.
Li H, Han G, He D, Wang Y, Lin Y, Zhang T, Wang J, Du Y, Li G, Wang Y, Zhou J, Liu B
Journal of healthcare engineering 2021;2021:5699025
Journal of healthcare engineering 2021;2021:5699025
Acetyl-CoA synthases are essential for maintaining histone acetylation under metabolic stress during zygotic genome activation in pigs.
Zhou W, Nie ZW, Zhou DJ, Cui XS
Journal of cellular physiology 2021 Oct;236(10):6948-6962
Journal of cellular physiology 2021 Oct;236(10):6948-6962
Aronia melanocarpa polysaccharide ameliorates inflammation and aging in mice by modulating the AMPK/SIRT1/NF-κB signaling pathway and gut microbiota.
Zhao Y, Liu X, Zheng Y, Liu W, Ding C
Scientific reports 2021 Oct 18;11(1):20558
Scientific reports 2021 Oct 18;11(1):20558
Maternally expressed 3 protects the intestinal barrier from cardiac arrest-induced ischemia/reperfusion injury via miR-34a-3p/sirtuin 1/nuclear factor kappa B signaling.
Huang X, Pan M, Du P, Chen Y, Zhang C, Lu W, Lin J
Annals of translational medicine 2021 Jan;9(2):122
Annals of translational medicine 2021 Jan;9(2):122
Endurance Exercise-Induced Autophagy/Mitophagy Coincides with a Reinforced Anabolic State and Increased Mitochondrial Turnover in the Cortex of Young Male Mouse Brain.
Kwon I, Jang Y, Lee Y
Journal of molecular neuroscience : MN 2021 Jan;71(1):42-54
Journal of molecular neuroscience : MN 2021 Jan;71(1):42-54
Melatonin protects mouse testes from palmitic acid-induced lipotoxicity by attenuating oxidative stress and DNA damage in a SIRT1-dependent manner.
Xu D, Liu L, Zhao Y, Yang L, Cheng J, Hua R, Zhang Z, Li Q
Journal of pineal research 2020 Nov;69(4):e12690
Journal of pineal research 2020 Nov;69(4):e12690
Resveratrol Attenuates Aortic Dissection by Increasing Endothelial Barrier Function Through the SIRT1 Pathway.
Wang K, Zhao J, Zhang W, Zhu M, Xu M, Li D, Shi H, Zhang M, Shi J, Dong Z
Journal of cardiovascular pharmacology 2020 Jul;76(1):86-93
Journal of cardiovascular pharmacology 2020 Jul;76(1):86-93
Ameliorative effects and mechanism of crocetin in arsenic trioxide‑induced cardiotoxicity in rats.
Zhao Z, Li J, Zheng B, Liang Y, Shi J, Zhang J, Han X, Chu L, Chu X, Gao Y
Molecular medicine reports 2020 Dec;22(6):5271-5281
Molecular medicine reports 2020 Dec;22(6):5271-5281
TP53 mutation influences the efficacy of treatment of colorectal cancer cell lines with a combination of sirtuin inhibitors and chemotherapeutic agents.
Yang H, Chen Y, Jiang Y, Wang D, Yan J, Zhou Z
Experimental and therapeutic medicine 2020 Aug;20(2):1415-1422
Experimental and therapeutic medicine 2020 Aug;20(2):1415-1422
Catalytic-independent neuroprotection by SIRT1 is mediated through interaction with HDAC1.
Pfister JA, Ma C, D'Mello SR
PloS one 2019;14(4):e0215208
PloS one 2019;14(4):e0215208
SIRT1 protects against urban particulate matter-induced airway inflammation.
Lai T, Wen X, Wu D, Su G, Gao Y, Chen C, Wu W, Lv Y, Chen Z, Lv Q, Li W, Li D, Chen M, Wu B
International journal of chronic obstructive pulmonary disease 2019;14:1741-1752
International journal of chronic obstructive pulmonary disease 2019;14:1741-1752
SIRT1-regulated HMGB1 release is partially involved in TLR4 signal transduction: A possible anti-neuroinflammatory mechanism of resveratrol in neonatal hypoxic-ischemic brain injury.
Le K, Chibaatar Daliv E, Wu S, Qian F, Ali AI, Yu D, Guo Y
International immunopharmacology 2019 Oct;75:105779
International immunopharmacology 2019 Oct;75:105779
Microglia Activated by Excess Cortisol Induce HMGB1 Acetylation and Neuroinflammation in the Hippocampal DG Region of Mice Following Cold Exposure.
Xu B, Lang LM, Li SZ, Guo JR, Wang JF, Yang HM, Lian S
Biomolecules 2019 Aug 30;9(9)
Biomolecules 2019 Aug 30;9(9)
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 60303-1-Ig( SIRT1 Antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-SIRT1 (IP:60303-1-Ig, 5ug; Detection:60303-1-Ig 1:1000) with HeLa cells lysate 2000ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The SIRT1 antibody from Proteintech is a mouse monoclonal antibody to a recombinant protein of human SIRT1. This antibody recognizes human antigen. The SIRT1 antibody has been validated for the following applications: ELISA, WB, IHC, IP analysis.
