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- Immunoprecipitation [1]
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- Product number
- 60303-1-Ig - Provider product page
- Provider
- Proteintech Group
- Product name
- SIRT1 antibody
- Antibody type
- Monoclonal
- Description
- KD/KO validated SIRT1 antibody (Cat. #60303-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 7F6G6
- Vial size
- 20ul, 150ul
Submitted references NMN protects cisplatin-associated AKI via NAD(+)/SIRT1 pathway.
Maresin 1 activates autophagy through SIRT1/PPAR-γ signaling to mitigate high glucose-induced pyroptosis in human retinal pigment epithelial cells.
HHV-6A Drives Epigenetic Reprogramming via an EZH2-SIRT1 Axis to Sustain Mutant p53 and Reshape Oncogenic Inflammatory Signaling.
SIRT1 deficiency promotes age-related heart failure through enhancing ferroptosis via GATA4-HADHA-GPX4 axis.
High‑intensity exercise training inhibits excessive autophagy in the hyperlipidemic myocardium of ApoE(‑/‑) mice via the NAD(+)‑mediated SIRT1/MFN2 pathway.
Homoplantaginin alleviates high glucose-induced vascular endothelial barrier dysfunction by regulating Yes-associated protein 1.
Tissue-specific effects of bacterial PncA overexpression on NAD(+) metabolism and aging in mice: implications for tissue-specific aging interventions.
Cordycepin ameliorates morphine tolerance by inhibiting spinal cord ferroptosis and inflammation via targeting SIRT1.
HIGD1A Alleviates Oxidative Stress Related Ovarian Hypofunction by Enhancing Granulosa Cell Functions via NF-κB/SOD2 Signaling Pathway.
Oxidative stress-induced ZEB1 acetylation drives a hybrid epithelial-mesenchymal phenotype and promotes lung metastasis in triple-negative breast cancer.
Targeting Intratumoral Copper Inhibits Tumor Progression via p62-Mediated EZH2 Degradation and Potentiates Anti-PD-1 Immunotherapy in Oral Squamous Cell Carcinoma.
H(2)O(2)-Activated Serotonin Precursor Probe for Mapping Neuronal Redox Homeostasis Reveals 5-HT Interactions with Neighboring Proteins Under Oxidative Stress.
SIRT1/PGC-1α/Mfn2 pathway regulates mitochondrial homeostasis in VSMC to attenuate aging-related vascular calcification.
Downregulation of forkhead box O1 (FOXO1) acetylation ameliorates cognitive dysfunction by inhibiting endoplasmic reticulum stress-regulated neuronal apoptosis in APP/PS1 transgenic mice.
ED-71 ameliorates OVX-induced osteoporosis by regulating calcium homeostasis and SIRT1-mediated mitochondrial function, alleviating osteoblast senescence and suppressing osteoclastogenesis.
Exploring the Mechanism of Kidney Injury in Mice Induced by High-Fat Diet and Polystyrene Nanoplastics Co-Exposure Through the Kidney-Gut Axis.
Microbiota governs host chenodeoxycholic acid glucuronidation to ameliorate bile acid disorder induced diarrhea.
TBX3 is Essential for Zygotic Genome Activation and Embryonic Development in Pigs.
Nucleocytoplasmic shuttling of sirtuin 1 regulates histone modifications and transcriptional events during early porcine embryonic development.
Melatonin improves synaptic morphological plasticity of adolescent male rats after perinatal BDE-209 exposure via SIRT1-mediated LIMK1 and CREB signaling.
Resveratrol alleviates depressive-like behavior via the activation of SIRT1/NF-κB signaling pathway in microglia.
Herbal Composition Inhibits Mitochondrial Oxidative Phosphorylation to Prevent HER2-Positive Breast Cancer and Identifies Potential Active Compounds.
Sirtuin 1-mediated recruitment of non-structural protein 1 to glucocorticoid receptor induces glucocorticoid insensitivity post RSV infection.
Buckwheat protein-derived peptide ameliorates insulin resistance by directing O-linked N-acetylglucosamine transferase to regulate the SIRT1/PGC1α pathway.
Taxifolin ameliorates the D-galactose-induced aging of mouse hippocampal neurons HT-22 cells through modulating SIRT1/p53 and PI3K/AKT signaling pathways.
ED-71 Ameliorates Bone Loss in Type 2 Diabetes Mellitus by Enhancing Osteogenesis Through Upregulation of the Circadian Rhythm Coregulator BMAL1.
Puerarin suppresses macrophage M1 polarization to alleviate renal inflammatory injury through antagonizing TLR4/MyD88-mediated NF-κB p65 and JNK/FoxO1 activation.
SIRT1 Regulates Mitochondrial Damage in N2a Cells Treated with the Prion Protein Fragment 106-126 via PGC-1α-TFAM-Mediated Mitochondrial Biogenesis.
Resveratrol protects against a high-fat diet-induced neuroinflammation by suppressing mitochondrial fission via targeting SIRT1/PGC-1α.
Decreased in Mitochondrial Complex I Subunit NDUFS2 Is Critical for Oocyte Quality During Postovulatory Aging in Pigs.
IDH2 and GLUD1 depletion arrests embryonic development through an H4K20me3 epigenetic barrier in porcine parthenogenetic embryos.
Restoration of ARA metabolic disorders in vascular smooth muscle cells alleviates intimal hyperplasia.
Fucoxanthin ameliorates endoplasmic reticulum stress and inhibits apoptosis and alleviates intervertebral disc degeneration in rats by upregulating Sirt1.
Electroacupuncture improves cognitive function in a rat model of mild traumatic brain injury by regulating the SIRT-1/PGC-1α/mitochondrial pathway.
Resveratrol attenuates cyclosporin A-induced upregulation of the thromboxane A(2) receptor and hypertension via the AMPK/SIRT1 and MAPK/NF-κB pathways in the rat mesenteric artery.
Mitochondrial glycerol 3-phosphate dehydrogenase deficiency exacerbates lipotoxic cardiomyopathy.
Sirt1 inhibits macrophage polarization and inflammation in gouty arthritis by inhibiting the MAPK/NF-κB/AP-1 pathway and activating the Nrf2/HO-1 pathway.
BACH1 inhibits senescence, obesity, and short lifespan by ferroptotic FGF21 secretion.
NADase CD38 is a key determinant of ovarian aging.
High-fat diet induces cognitive impairment through repression of SIRT1/AMPK-mediated autophagy.
Metformin protects ovarian granulosa cells in chemotherapy-induced premature ovarian failure mice through AMPK/PPAR-γ/SIRT1 pathway.
Nicotinamide mononucleotide pretreatment improves long-term isoflurane anesthesia-induced cognitive impairment in mice.
The use of a systems approach to increase NAD(+) in human participants.
Effects of Losartan and Fisetin on Microfracture-Mediated Cartilage Repair of Ankle Cartilage in a Rabbit Model.
MAT2A is essential for zygotic genome activation by maintaining of histone methylation in porcine embryos.
Sirtuin 1-mediated autophagy regulates testosterone synthesis in Leydig cells of piglets.
A novel method for exploration and prediction of the bioactive target of rice bran-derived peptide (KF-8) by integrating computational methods and experiments.
Axonal endoplasmic reticulum tubules control local translation via P180/RRBP1-mediated ribosome interactions.
Progesterone (P4) ameliorates cigarette smoke-induced chronic obstructive pulmonary disease (COPD).
Pyrroloquinoline quinone promotes human mesenchymal stem cell-derived mitochondria to improve premature ovarian insufficiency in mice through the SIRT1/ATM/p53 pathway.
Nobiletin enhances mitochondrial function by regulating SIRT1/PGC-1α signaling in porcine oocytes during in vitro maturation.
Resveratrol Improves the Progression of Osteoarthritis by Regulating the SIRT1-FoxO1 Pathway-Mediated Cholesterol Metabolism.
Protectin DX Relieve Hyperoxia-induced Lung Injury by Protecting Pulmonary Endothelial Glycocalyx.
Eldecalcitol prevented OVX-induced osteoporosis through inhibiting BMSCs senescence by regulating the SIRT1-Nrf2 signal.
Knockdown of Y-box binding protein 1 induces autophagy in early porcine embryos.
Menaquinone-4 prevents medication-related osteonecrosis of the jaw through the SIRT1 signaling-mediated inhibition of cellular metabolic stresses-induced osteoblast apoptosis.
Investigation of the potential ameliorative effects of DHA-enriched phosphatidylserine on bisphenol A-induced murine nephrotoxicity.
Muscle PARP1 inhibition extends lifespan through AMPKα PARylation and activation in Drosophila.
HypERlnc attenuates angiotensin II-induced cardiomyocyte hypertrophy via promoting SIRT1 SUMOylation-mediated activation of PGC-1α/PPARα pathway in AC16 cells.
Glycolytic reprogramming controls periodontitis-associated macrophage pyroptosis via AMPK/SIRT1/NF-κB signaling pathway.
Y-box binding protein 1 influences zygotic genome activation by regulating N6-methyladenosine in porcine embryos.
Modulatory effect of n-3 polyunsaturated fatty acids on depressive-like behaviors in rats with chronic sleep deprivation: potential involvement of melatonin receptor pathway and brain lipidome.
Long non-coding RNA HOXC-AS1 exerts its oncogenic effects in esophageal squamous cell carcinoma by interaction with IGF2BP2 to stabilize SIRT1 expression.
Dietary selenium excess affected spermatogenesis via DNA damage and telomere-related cell senescence and apoptosis in mice.
Fyn deficiency inhibits oxidative stress by decreasing c-Cbl-mediated ubiquitination of Sirt1 to attenuate diabetic renal fibrosis.
GRP78 acts as a cAMP/PKA signaling modulator through the MC4R pathway in porcine embryonic development.
Resveratrol improves follicular development of PCOS rats via regulating glycolysis pathway and targeting SIRT1.
An Energy Metabolism Study on the Efficacy of Naoxintong Capsules against Myocardial Infarction in a Rat Model.
Mesenchymal Stem Cell-Derived Exosomes Ameliorate Delayed Neurocognitive Recovery in Aged Mice by Inhibiting Hippocampus Ferroptosis via Activating SIRT1/Nrf2/HO-1 Signaling Pathway.
Rotenone causes mitochondrial dysfunction and prevents maturation in porcine oocytes.
Sirtuin Type 1 Mediates the Antidepressant Effect of S-Ketamine in a Chronic Unpredictable Stress Model.
Protocatechualdehyde Rescues Oxygen-Glucose Deprivation/Reoxygenation-Induced Endothelial Cells Injury by Inducing Autophagy and Inhibiting Apoptosis via Regulation of SIRT1.
Curcumol alleviates liver fibrosis by inducing endoplasmic reticulum stress-mediated necroptosis of hepatic stellate cells through Sirt1/NICD pathway.
Resveratrol protection against IL-1β-induced chondrocyte damage via the SIRT1/FOXO1 signaling pathway.
SIRT1/mTOR pathway-mediated autophagy dysregulation promotes Pb-induced hepatic lipid accumulation in HepG2 cells.
Modification of lysine deacetylation regulates curcumol-induced necroptosis through autophagy in hepatic stellate cells.
Curcumin attenuates isoniazid-induced hepatotoxicity by upregulating the SIRT1/PGC-1α/NRF1 pathway.
Berberine exerts protective effects on cardiac senescence by regulating the Klotho/SIRT1 signaling pathway.
COX-2/sEH Dual Inhibitor Alleviates Hepatocyte Senescence in NAFLD Mice by Restoring Autophagy through Sirt1/PI3K/AKT/mTOR.
Phenylalanine impairs insulin signaling and inhibits glucose uptake through modification of IRβ.
Exposure to Bisphenol A Caused Hepatoxicity and Intestinal Flora Disorder in Rats.
Resveratrol Improves Synaptic Plasticity in Hypoxic-Ischemic Brain Injury in Neonatal Mice via Alleviating SIRT1/NF-κB Signaling-Mediated Neuroinflammation.
G0S2 ameliorates oxidized low-density lipoprotein-induced vascular endothelial cell injury by regulating mitochondrial apoptosis.
The vesicular transporter STX11 governs ATGL-mediated hepatic lipolysis and lipophagy.
Ginsenoside CK Inhibits TGF-β-Induced Epithelial-Mesenchymal Transition in A549 Cell via SIRT1.
miR-539 Targeting SNAI2 Regulates MMP9 Signaling Pathway and Affects Blood-Brain Barrier Permeability in Cerebrovascular Occlusive Diseases: A Study Based on Head and Neck Ultrasound and CTA.
Acetyl-CoA synthases are essential for maintaining histone acetylation under metabolic stress during zygotic genome activation in pigs.
Aronia melanocarpa polysaccharide ameliorates inflammation and aging in mice by modulating the AMPK/SIRT1/NF-κB signaling pathway and gut microbiota.
Maternally expressed 3 protects the intestinal barrier from cardiac arrest-induced ischemia/reperfusion injury via miR-34a-3p/sirtuin 1/nuclear factor kappa B signaling.
Endurance Exercise-Induced Autophagy/Mitophagy Coincides with a Reinforced Anabolic State and Increased Mitochondrial Turnover in the Cortex of Young Male Mouse Brain.
Melatonin protects mouse testes from palmitic acid-induced lipotoxicity by attenuating oxidative stress and DNA damage in a SIRT1-dependent manner.
Resveratrol Attenuates Aortic Dissection by Increasing Endothelial Barrier Function Through the SIRT1 Pathway.
Ameliorative effects and mechanism of crocetin in arsenic trioxide‑induced cardiotoxicity in rats.
TP53 mutation influences the efficacy of treatment of colorectal cancer cell lines with a combination of sirtuin inhibitors and chemotherapeutic agents.
Catalytic-independent neuroprotection by SIRT1 is mediated through interaction with HDAC1.
SIRT1 protects against urban particulate matter-induced airway inflammation.
SIRT1-regulated HMGB1 release is partially involved in TLR4 signal transduction: A possible anti-neuroinflammatory mechanism of resveratrol in neonatal hypoxic-ischemic brain injury.
Microglia Activated by Excess Cortisol Induce HMGB1 Acetylation and Neuroinflammation in the Hippocampal DG Region of Mice Following Cold Exposure.
Wen Z, Wang J, Yang Y, Chen L, Ji X, Liu D, Shi C
Frontiers in immunology 2026;17:1721884
Frontiers in immunology 2026;17:1721884
Maresin 1 activates autophagy through SIRT1/PPAR-γ signaling to mitigate high glucose-induced pyroptosis in human retinal pigment epithelial cells.
Zhang J, Zhao D, Zhang Y, Sun H, Yan Z, Sun H
Experimental and therapeutic medicine 2026 May;31(5):141
Experimental and therapeutic medicine 2026 May;31(5):141
HHV-6A Drives Epigenetic Reprogramming via an EZH2-SIRT1 Axis to Sustain Mutant p53 and Reshape Oncogenic Inflammatory Signaling.
Benedetti R, Di Crosta M, Stirparo A, Aron GA, Mardente S, Santarelli R, Gonnella R, Gilardini Montani MS, Cirone M
Viruses 2026 Mar 26;18(4)
Viruses 2026 Mar 26;18(4)
SIRT1 deficiency promotes age-related heart failure through enhancing ferroptosis via GATA4-HADHA-GPX4 axis.
Duan Y, Luo Y, Han X, Yu H, Liu H, Zhou Y, Gao Y, Xu Q, Wei Y, Min R, Hong Y, Ji X, Jia H, Li Y, Zhang Y
Cell death & disease 2026 Mar 23;17(1)
Cell death & disease 2026 Mar 23;17(1)
High‑intensity exercise training inhibits excessive autophagy in the hyperlipidemic myocardium of ApoE(‑/‑) mice via the NAD(+)‑mediated SIRT1/MFN2 pathway.
Gao S, Yao W, Yang J, Liu Y, Pei Z
Molecular medicine reports 2026 Jan;33(1)
Molecular medicine reports 2026 Jan;33(1)
Homoplantaginin alleviates high glucose-induced vascular endothelial barrier dysfunction by regulating Yes-associated protein 1.
Li X, Wang J, Wang L, Sha X, Huang S, Ren M, Cheng L, Zhang Y, Zhou W, Lin Y, Wu F
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:157953
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:157953
Tissue-specific effects of bacterial PncA overexpression on NAD(+) metabolism and aging in mice: implications for tissue-specific aging interventions.
Huo F, Zhao M, Liu Y, Lv S, Feng S, Guo L, Wang N, Zhang S, Liu Q, Mi T, Wang H, Zhu JK, Liu H
Frontiers in aging 2025;6:1546017
Frontiers in aging 2025;6:1546017
Cordycepin ameliorates morphine tolerance by inhibiting spinal cord ferroptosis and inflammation via targeting SIRT1.
Li Z, Liu J, Ju J, Peng X, Zhao W, Ren J, Jia X, Wang J, Gao F
International journal of medical sciences 2025;22(9):2059-2074
International journal of medical sciences 2025;22(9):2059-2074
HIGD1A Alleviates Oxidative Stress Related Ovarian Hypofunction by Enhancing Granulosa Cell Functions via NF-κB/SOD2 Signaling Pathway.
Li H, Cai S, Mu H, Chang T, Wang X, Tang T, Dong T, Zhang Y, Zhang L, Li H, Zhou L, Xiang W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(34):e03828
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(34):e03828
Oxidative stress-induced ZEB1 acetylation drives a hybrid epithelial-mesenchymal phenotype and promotes lung metastasis in triple-negative breast cancer.
Guo M, Wang YJ, Shi J, Cao LX, Ou Y, Jia X, Qi CC, Li ZX, Liu YX, Zuo SY, Shuai QY, Yu TW, Hu HY, Chen X, Feng MD, Xue Y, Wang H, Sun PQ, Liu L, Shi Y, Yang S
Redox biology 2025 Oct;86:103834
Redox biology 2025 Oct;86:103834
Targeting Intratumoral Copper Inhibits Tumor Progression via p62-Mediated EZH2 Degradation and Potentiates Anti-PD-1 Immunotherapy in Oral Squamous Cell Carcinoma.
Lin X, Chen W, Li B, Zhao Z, Yu Z, Zhao XY, Zhou X, Feng Z, Lin C, Cao W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(40):e17795
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(40):e17795
H(2)O(2)-Activated Serotonin Precursor Probe for Mapping Neuronal Redox Homeostasis Reveals 5-HT Interactions with Neighboring Proteins Under Oxidative Stress.
Liu Y, Yuan J, Zhang T, Cai X, Xu M, Wang X, Wang R, Zhang B, Zhu HL, Qian Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(39):e02360
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(39):e02360
SIRT1/PGC-1α/Mfn2 pathway regulates mitochondrial homeostasis in VSMC to attenuate aging-related vascular calcification.
Wu C, Wu Z, Hu L, Tang L, Hu X, Fang C
Scientific reports 2025 Oct 30;15(1):38045
Scientific reports 2025 Oct 30;15(1):38045
Downregulation of forkhead box O1 (FOXO1) acetylation ameliorates cognitive dysfunction by inhibiting endoplasmic reticulum stress-regulated neuronal apoptosis in APP/PS1 transgenic mice.
Zhang N, Zhao Z, Chen X, Yao H, Zhu M, Ma S, Wang H, Yin X, Zhou Y, Zheng C, Li J, Pan J, Wang K, Yang B, Wang Y, Fan J, Gong Y, Liu R, Zeng J, Fan X, Shentu Y
Neuroprotection (Chichester, England) 2025 Jun;3(2):183-201
Neuroprotection (Chichester, England) 2025 Jun;3(2):183-201
ED-71 ameliorates OVX-induced osteoporosis by regulating calcium homeostasis and SIRT1-mediated mitochondrial function, alleviating osteoblast senescence and suppressing osteoclastogenesis.
Zhang Y, Cui Y, Sun C, Guo J, Li M
Cellular signalling 2025 Jul;131:111713
Cellular signalling 2025 Jul;131:111713
Exploring the Mechanism of Kidney Injury in Mice Induced by High-Fat Diet and Polystyrene Nanoplastics Co-Exposure Through the Kidney-Gut Axis.
Dong J, Yang F, Xu Y, Zhao Q, Li X, Liu T, Tang Y
Journal of agricultural and food chemistry 2025 Jul 16;73(28):17956-17966
Journal of agricultural and food chemistry 2025 Jul 16;73(28):17956-17966
Microbiota governs host chenodeoxycholic acid glucuronidation to ameliorate bile acid disorder induced diarrhea.
Lin Z, Feng Y, Wang J, Men Z, Ma X
Microbiome 2025 Feb 4;13(1):36
Microbiome 2025 Feb 4;13(1):36
TBX3 is Essential for Zygotic Genome Activation and Embryonic Development in Pigs.
Li XH, Lee SH, Kim JD, Lee GH, Sim JM, Cui XS
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 2025 Feb 17;31(1)
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 2025 Feb 17;31(1)
Nucleocytoplasmic shuttling of sirtuin 1 regulates histone modifications and transcriptional events during early porcine embryonic development.
Lee SH, Lu QY, Zhan CL, Kim JD, Lee GH, Sim JM, Song HJ, Cui XS
International journal of biological macromolecules 2025 Dec;334(Pt 2):149016
International journal of biological macromolecules 2025 Dec;334(Pt 2):149016
Melatonin improves synaptic morphological plasticity of adolescent male rats after perinatal BDE-209 exposure via SIRT1-mediated LIMK1 and CREB signaling.
Gao J, Shen J, Gao L, Yan D, Wang Y, Meng J, Chen D, Li H, Wu J
Neurotoxicology 2025 Dec;111:103331
Neurotoxicology 2025 Dec;111:103331
Resveratrol alleviates depressive-like behavior via the activation of SIRT1/NF-κB signaling pathway in microglia.
Wu Y, Zhu Y, Zheng S, Mingxing D
Future science OA 2025 Dec;11(1):2463852
Future science OA 2025 Dec;11(1):2463852
Herbal Composition Inhibits Mitochondrial Oxidative Phosphorylation to Prevent HER2-Positive Breast Cancer and Identifies Potential Active Compounds.
Zhao Y, Hu W, Wang X, Ren Z, Gong Y, Liu L, Sun Y
International journal of molecular sciences 2025 Dec 12;26(24)
International journal of molecular sciences 2025 Dec 12;26(24)
Sirtuin 1-mediated recruitment of non-structural protein 1 to glucocorticoid receptor induces glucocorticoid insensitivity post RSV infection.
Che S, Long X, Mo S, Jiang Z, Xie X, Liu E, Xie J
International journal of biological macromolecules 2025 Aug;320(Pt 1):145811
International journal of biological macromolecules 2025 Aug;320(Pt 1):145811
Buckwheat protein-derived peptide ameliorates insulin resistance by directing O-linked N-acetylglucosamine transferase to regulate the SIRT1/PGC1α pathway.
Yang J, Hou S, Zhao Y, Sun Z, Zhang L, Deng Y, Shang X, Yu H, Li Z, Li H
International journal of biological macromolecules 2025 Apr;304(Pt 2):140925
International journal of biological macromolecules 2025 Apr;304(Pt 2):140925
Taxifolin ameliorates the D-galactose-induced aging of mouse hippocampal neurons HT-22 cells through modulating SIRT1/p53 and PI3K/AKT signaling pathways.
Liu XL, Zu S, Yue H, Li AN, Sun PP, Li JG, Yan L, Ma LN, Zhang S
Journal of Asian natural products research 2025 Apr;27(4):615-631
Journal of Asian natural products research 2025 Apr;27(4):615-631
ED-71 Ameliorates Bone Loss in Type 2 Diabetes Mellitus by Enhancing Osteogenesis Through Upregulation of the Circadian Rhythm Coregulator BMAL1.
Liu T, Wang L, Shi T, Liu H, Liu B, Guo J, Li M
Drug design, development and therapy 2024;18:3903-3919
Drug design, development and therapy 2024;18:3903-3919
Puerarin suppresses macrophage M1 polarization to alleviate renal inflammatory injury through antagonizing TLR4/MyD88-mediated NF-κB p65 and JNK/FoxO1 activation.
Hu Z, Chen D, Yan P, Zheng F, Zhu H, Yuan Z, Yang X, Zuo Y, Chen C, Lu H, Wu L, Lyu J, Bai Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155813
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155813
SIRT1 Regulates Mitochondrial Damage in N2a Cells Treated with the Prion Protein Fragment 106-126 via PGC-1α-TFAM-Mediated Mitochondrial Biogenesis.
Zhao M, Li J, Li Z, Yang D, Wang D, Sun Z, Wen P, Gou F, Dai Y, Ji Y, Li W, Zhao D, Yang L
International journal of molecular sciences 2024 Sep 7;25(17)
International journal of molecular sciences 2024 Sep 7;25(17)
Resveratrol protects against a high-fat diet-induced neuroinflammation by suppressing mitochondrial fission via targeting SIRT1/PGC-1α.
Su X, Li Q, Yang M, Zhang W, Liu X, Ba Y, Deng Q, Zhang Y, Han L, Huang H
Experimental neurology 2024 Oct;380:114899
Experimental neurology 2024 Oct;380:114899
Decreased in Mitochondrial Complex I Subunit NDUFS2 Is Critical for Oocyte Quality During Postovulatory Aging in Pigs.
Zhou D, Lee SH, Li XH, Kim JD, Lee GH, Sim JM, Cui XS
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 2024 Nov 4;30(5):953-961
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 2024 Nov 4;30(5):953-961
IDH2 and GLUD1 depletion arrests embryonic development through an H4K20me3 epigenetic barrier in porcine parthenogenetic embryos.
Zhan CL, Lu QY, Lee SH, Li XH, Kim JD, Lee GH, Sim JM, Song HJ, Jin YY, Cui XS
Zoological research 2024 Nov 18;45(6):1175-1187
Zoological research 2024 Nov 18;45(6):1175-1187
Restoration of ARA metabolic disorders in vascular smooth muscle cells alleviates intimal hyperplasia.
Wu H, Li D, Zhang CY, Huang LL, Zeng YJ, Chen TG, Yu K, Meng JW, Lin YX, Guo R, Zhou Y, Gao G
European journal of pharmacology 2024 Nov 15;983:176824
European journal of pharmacology 2024 Nov 15;983:176824
Fucoxanthin ameliorates endoplasmic reticulum stress and inhibits apoptosis and alleviates intervertebral disc degeneration in rats by upregulating Sirt1.
Teng C, Wu J, Zhang Z, Wang J, Yang Y, Dong C, Wu L, Lin Z, Hu Y, Wang J, Zhang X, Lin Z
Phytotherapy research : PTR 2024 May;38(5):2114-2127
Phytotherapy research : PTR 2024 May;38(5):2114-2127
Electroacupuncture improves cognitive function in a rat model of mild traumatic brain injury by regulating the SIRT-1/PGC-1α/mitochondrial pathway.
Jin B, Gao Y, Fu Y, Zhang S, Zhang K, Su Y
Chinese medical journal 2024 Mar 20;137(6):711-719
Chinese medical journal 2024 Mar 20;137(6):711-719
Resveratrol attenuates cyclosporin A-induced upregulation of the thromboxane A(2) receptor and hypertension via the AMPK/SIRT1 and MAPK/NF-κB pathways in the rat mesenteric artery.
Li Q, Cao H, Xu X, Chen Y, Zhang Y, Mi Y, Zhu X, Shi Y, Liu J, Wang B, Xu CB, Wang C
European journal of pharmacology 2024 Jun 5;972:176543
European journal of pharmacology 2024 Jun 5;972:176543
Mitochondrial glycerol 3-phosphate dehydrogenase deficiency exacerbates lipotoxic cardiomyopathy.
Qu H, Liu X, Zhu J, He N, He Q, Zhang L, Wang Y, Gong X, Xiong X, Liu J, Wang C, Yang G, Yang Q, Luo G, Zhu Z, Zheng Y, Zheng H
iScience 2024 Jun 21;27(6):109796
iScience 2024 Jun 21;27(6):109796
Sirt1 inhibits macrophage polarization and inflammation in gouty arthritis by inhibiting the MAPK/NF-κB/AP-1 pathway and activating the Nrf2/HO-1 pathway.
Zhao X, Li M, Lu Y, Wang M, Xiao J, Xie Q, He X, Shuai S
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2024 Jul;73(7):1173-1184
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2024 Jul;73(7):1173-1184
BACH1 inhibits senescence, obesity, and short lifespan by ferroptotic FGF21 secretion.
Nishizawa H, Matsumoto M, Yamanaka M, Irikura R, Nakajima K, Tada K, Nakayama Y, Konishi M, Itoh N, Funayama R, Nakayama K, Igarashi K
Cell reports 2024 Jul 23;43(7):114403
Cell reports 2024 Jul 23;43(7):114403
NADase CD38 is a key determinant of ovarian aging.
Yang Q, Chen W, Cong L, Wang M, Li H, Wang H, Luo X, Zhu J, Zeng X, Zhu Z, Xu Y, Lei M, Zhao Y, Wei C, Sun Y
Nature aging 2024 Jan;4(1):110-128
Nature aging 2024 Jan;4(1):110-128
High-fat diet induces cognitive impairment through repression of SIRT1/AMPK-mediated autophagy.
Yi W, Chen F, Yuan M, Wang C, Wang S, Wen J, Zou Q, Pu Y, Cai Z
Experimental neurology 2024 Jan;371:114591
Experimental neurology 2024 Jan;371:114591
Metformin protects ovarian granulosa cells in chemotherapy-induced premature ovarian failure mice through AMPK/PPAR-γ/SIRT1 pathway.
Yang Y, Tang X, Yao T, Zhang Y, Zhong Y, Wu S, Wang Y, Pan Z
Scientific reports 2024 Jan 16;14(1):1447
Scientific reports 2024 Jan 16;14(1):1447
Nicotinamide mononucleotide pretreatment improves long-term isoflurane anesthesia-induced cognitive impairment in mice.
Xu J, Chen X, Liu S, Wei Z, Xu M, Jiang L, Han X, Peng L, Gu X, Xia T
Behavioural brain research 2024 Feb 26;458:114738
Behavioural brain research 2024 Feb 26;458:114738
The use of a systems approach to increase NAD(+) in human participants.
Henderson JD, Quigley SNZ, Chachra SS, Conlon N, Ford D
npj aging 2024 Feb 1;10(1):7
npj aging 2024 Feb 1;10(1):7
Effects of Losartan and Fisetin on Microfracture-Mediated Cartilage Repair of Ankle Cartilage in a Rabbit Model.
Stake IK, Gao X, Huard M, Fukase N, Ruzbarsky JJ, Ravuri S, Layne JE, Philippon MJ, Clanton TO, Huard J
The American journal of sports medicine 2024 Dec;52(14):3625-3640
The American journal of sports medicine 2024 Dec;52(14):3625-3640
MAT2A is essential for zygotic genome activation by maintaining of histone methylation in porcine embryos.
Li XH, Lee SH, Lu QY, Zhan CL, Lee GH, Kim JD, Sim JM, Song HJ, Cui XS
Theriogenology 2024 Dec;230:81-90
Theriogenology 2024 Dec;230:81-90
Sirtuin 1-mediated autophagy regulates testosterone synthesis in Leydig cells of piglets.
Zhang Y, Yu L, He Y, Liu C, Abouelfetouh MM, Ju S, Zhou Z, Li Q
Theriogenology 2024 Dec;230:130-141
Theriogenology 2024 Dec;230:130-141
A novel method for exploration and prediction of the bioactive target of rice bran-derived peptide (KF-8) by integrating computational methods and experiments.
Liang R, Song F, Liang Y, Fang Y, Wang J, Chen Y, Chen Z, Tan X, Dong J
Food & function 2024 Dec 9;15(24):11875-11887
Food & function 2024 Dec 9;15(24):11875-11887
Axonal endoplasmic reticulum tubules control local translation via P180/RRBP1-mediated ribosome interactions.
Koppers M, Özkan N, Nguyen HH, Jurriens D, McCaughey J, Nguyen DTM, Li CH, Stucchi R, Altelaar M, MacGillavry HD, Kapitein LC, Hoogenraad CC, Farías GG
Developmental cell 2024 Aug 19;59(16):2053-2068.e9
Developmental cell 2024 Aug 19;59(16):2053-2068.e9
Progesterone (P4) ameliorates cigarette smoke-induced chronic obstructive pulmonary disease (COPD).
Xie B, Chen Q, Dai Z, Jiang C, Chen X
Molecular medicine (Cambridge, Mass.) 2024 Aug 13;30(1):123
Molecular medicine (Cambridge, Mass.) 2024 Aug 13;30(1):123
Pyrroloquinoline quinone promotes human mesenchymal stem cell-derived mitochondria to improve premature ovarian insufficiency in mice through the SIRT1/ATM/p53 pathway.
Liu S, Wang Y, Yang H, Tan J, Zhang J, Zi D
Stem cell research & therapy 2024 Apr 5;15(1):97
Stem cell research & therapy 2024 Apr 5;15(1):97
Nobiletin enhances mitochondrial function by regulating SIRT1/PGC-1α signaling in porcine oocytes during in vitro maturation.
Lee SH, Li XH, Lu QY, Zhan CL, Kim JD, Lee GH, Sim JM, Cui XS
Biochemical and biophysical research communications 2024 Apr 30;706:149747
Biochemical and biophysical research communications 2024 Apr 30;706:149747
Resveratrol Improves the Progression of Osteoarthritis by Regulating the SIRT1-FoxO1 Pathway-Mediated Cholesterol Metabolism.
Liang C, Xing H, Wang C, Xu X, Hao Y, Qiu B
Mediators of inflammation 2023;2023:2936236
Mediators of inflammation 2023;2023:2936236
Protectin DX Relieve Hyperoxia-induced Lung Injury by Protecting Pulmonary Endothelial Glycocalyx.
Liang Z, Yue H, Xu C, Wang Q, Jin S
Journal of inflammation research 2023;16:421-431
Journal of inflammation research 2023;16:421-431
Eldecalcitol prevented OVX-induced osteoporosis through inhibiting BMSCs senescence by regulating the SIRT1-Nrf2 signal.
Kou Y, Rong X, Tang R, Zhang Y, Yang P, Liu H, Ma W, Li M
Frontiers in pharmacology 2023;14:1067085
Frontiers in pharmacology 2023;14:1067085
Knockdown of Y-box binding protein 1 induces autophagy in early porcine embryos.
Jiang WJ, Lee SH, Heo G, Chung HJ, Cho ES, Sa SJ, Hochi S, Cui XS
Frontiers in cell and developmental biology 2023;11:1238546
Frontiers in cell and developmental biology 2023;11:1238546
Menaquinone-4 prevents medication-related osteonecrosis of the jaw through the SIRT1 signaling-mediated inhibition of cellular metabolic stresses-induced osteoblast apoptosis.
Cui Y, Zhang W, Yang P, Zhu S, Luo S, Li M
Free radical biology & medicine 2023 Sep;206:33-49
Free radical biology & medicine 2023 Sep;206:33-49
Investigation of the potential ameliorative effects of DHA-enriched phosphatidylserine on bisphenol A-induced murine nephrotoxicity.
Pu Q, Yang F, Zhao R, Jiang S, Tang Y, Han T
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Oct;180:114012
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Oct;180:114012
Muscle PARP1 inhibition extends lifespan through AMPKα PARylation and activation in Drosophila.
Guo S, Zhang S, Zhuang Y, Xie F, Wang R, Kong X, Zhang Q, Feng Y, Gao H, Kong X, Liu T
Proceedings of the National Academy of Sciences of the United States of America 2023 Mar 28;120(13):e2213857120
Proceedings of the National Academy of Sciences of the United States of America 2023 Mar 28;120(13):e2213857120
HypERlnc attenuates angiotensin II-induced cardiomyocyte hypertrophy via promoting SIRT1 SUMOylation-mediated activation of PGC-1α/PPARα pathway in AC16 cells.
Yue L, Sheng S, Yuan M, Lu J, Li T, Shi Y, Dong Z
Cell biology international 2023 Jun;47(6):1068-1080
Cell biology international 2023 Jun;47(6):1068-1080
Glycolytic reprogramming controls periodontitis-associated macrophage pyroptosis via AMPK/SIRT1/NF-κB signaling pathway.
He Y, Wang Y, Jia X, Li Y, Yang Y, Pan L, Zhao R, Han Y, Wang F, Guan X, Hou T
International immunopharmacology 2023 Jun;119:110192
International immunopharmacology 2023 Jun;119:110192
Y-box binding protein 1 influences zygotic genome activation by regulating N6-methyladenosine in porcine embryos.
Jiang WJ, Sun MH, Li XH, Lee SH, Heo G, Zhou D, Cui XS
Journal of cellular physiology 2023 Jul;238(7):1592-1604
Journal of cellular physiology 2023 Jul;238(7):1592-1604
Modulatory effect of n-3 polyunsaturated fatty acids on depressive-like behaviors in rats with chronic sleep deprivation: potential involvement of melatonin receptor pathway and brain lipidome.
Chang CH, Wu HC, Hsieh YR, Lai WD, Tung TH, Huang JJ, Kao WY, Huang SY
Food & function 2023 Jul 3;14(13):5977-5993
Food & function 2023 Jul 3;14(13):5977-5993
Long non-coding RNA HOXC-AS1 exerts its oncogenic effects in esophageal squamous cell carcinoma by interaction with IGF2BP2 to stabilize SIRT1 expression.
Yang Z, Wan J, Ma L, Li Z, Yang R, Yang H, Li J, Zhou F, Ming L
Journal of clinical laboratory analysis 2023 Jan;37(1):e24801
Journal of clinical laboratory analysis 2023 Jan;37(1):e24801
Dietary selenium excess affected spermatogenesis via DNA damage and telomere-related cell senescence and apoptosis in mice.
Zhang Y, Liu J, Li X, Zhou G, Sang Y, Zhang M, Gao L, Xue J, Zhao M, Yu H, Zhou X
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jan;171:113556
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jan;171:113556
Fyn deficiency inhibits oxidative stress by decreasing c-Cbl-mediated ubiquitination of Sirt1 to attenuate diabetic renal fibrosis.
Li S, Lin Z, Xiao H, Xu Z, Li C, Zeng J, Xie X, Deng L, Huang H
Metabolism: clinical and experimental 2023 Feb;139:155378
Metabolism: clinical and experimental 2023 Feb;139:155378
GRP78 acts as a cAMP/PKA signaling modulator through the MC4R pathway in porcine embryonic development.
Heo G, Lee SH, Kim JD, Lee GH, Sim JM, Zhou D, Guo J, Cui XS
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Dec;37(12):e23274
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Dec;37(12):e23274
Resveratrol improves follicular development of PCOS rats via regulating glycolysis pathway and targeting SIRT1.
Huo P, Li M, Le J, Zhu C, Yao J, Zhang S
Systems biology in reproductive medicine 2023 Apr;69(2):153-165
Systems biology in reproductive medicine 2023 Apr;69(2):153-165
An Energy Metabolism Study on the Efficacy of Naoxintong Capsules against Myocardial Infarction in a Rat Model.
Zhao J, Ouyang Y, Wang H, Lai H, Hu S, Tang L, Yang H, Wu H
Oxidative medicine and cellular longevity 2022;2022:3712500
Oxidative medicine and cellular longevity 2022;2022:3712500
Mesenchymal Stem Cell-Derived Exosomes Ameliorate Delayed Neurocognitive Recovery in Aged Mice by Inhibiting Hippocampus Ferroptosis via Activating SIRT1/Nrf2/HO-1 Signaling Pathway.
Liu J, Huang J, Zhang Z, Zhang R, Sun Q, Zhang Z, Liu Y, Ma B
Oxidative medicine and cellular longevity 2022;2022:3593294
Oxidative medicine and cellular longevity 2022;2022:3593294
Rotenone causes mitochondrial dysfunction and prevents maturation in porcine oocytes.
Heo G, Sun MH, Jiang WJ, Li XH, Lee SH, Guo J, Zhou D, Cui XS
PloS one 2022;17(11):e0277477
PloS one 2022;17(11):e0277477
Sirtuin Type 1 Mediates the Antidepressant Effect of S-Ketamine in a Chronic Unpredictable Stress Model.
Hou L, Miao J, Meng H, Liu X, Wang D, Tan Y, Li C
Frontiers in psychiatry 2022;13:855810
Frontiers in psychiatry 2022;13:855810
Protocatechualdehyde Rescues Oxygen-Glucose Deprivation/Reoxygenation-Induced Endothelial Cells Injury by Inducing Autophagy and Inhibiting Apoptosis via Regulation of SIRT1.
Cao S, Chen S, Qiao X, Guo Y, Liu F, Ding Z, Jin B
Frontiers in pharmacology 2022;13:846513
Frontiers in pharmacology 2022;13:846513
Curcumol alleviates liver fibrosis by inducing endoplasmic reticulum stress-mediated necroptosis of hepatic stellate cells through Sirt1/NICD pathway.
Sun S, Huan S, Li Z, Yao Y, Su Y, Xia S, Wang S, Xu X, Shao J, Zhang Z, Zhang F, Fu J, Zheng S
PeerJ 2022;10:e13376
PeerJ 2022;10:e13376
Resveratrol protection against IL-1β-induced chondrocyte damage via the SIRT1/FOXO1 signaling pathway.
Liang C, Xing H, Wang C, Xu X, Hao Y, Qiu B
Journal of orthopaedic surgery and research 2022 Sep 5;17(1):406
Journal of orthopaedic surgery and research 2022 Sep 5;17(1):406
SIRT1/mTOR pathway-mediated autophagy dysregulation promotes Pb-induced hepatic lipid accumulation in HepG2 cells.
Zhao Y, Mao A, Zhang R, Guan S, Lu J
Environmental toxicology 2022 Mar;37(3):549-563
Environmental toxicology 2022 Mar;37(3):549-563
Modification of lysine deacetylation regulates curcumol-induced necroptosis through autophagy in hepatic stellate cells.
Sun S, Li Z, Huan S, Kai J, Xia S, Su Y, Ji S, Chen A, Wang S, Xu X, Shao J, Zhang F, Zhang B, Zhang Z, Zheng S
Phytotherapy research : PTR 2022 Jun;36(6):2660-2676
Phytotherapy research : PTR 2022 Jun;36(6):2660-2676
Curcumin attenuates isoniazid-induced hepatotoxicity by upregulating the SIRT1/PGC-1α/NRF1 pathway.
Li Y, Luo WW, Cheng X, Xiang HR, He B, Zhang QZ, Peng WX
Journal of applied toxicology : JAT 2022 Jul;42(7):1192-1204
Journal of applied toxicology : JAT 2022 Jul;42(7):1192-1204
Berberine exerts protective effects on cardiac senescence by regulating the Klotho/SIRT1 signaling pathway.
Li C, Jiang S, Wang H, Wang Y, Han Y, Jiang J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Jul;151:113097
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Jul;151:113097
COX-2/sEH Dual Inhibitor Alleviates Hepatocyte Senescence in NAFLD Mice by Restoring Autophagy through Sirt1/PI3K/AKT/mTOR.
Zhang CY, Tan XH, Yang HH, Jin L, Hong JR, Zhou Y, Huang XT
International journal of molecular sciences 2022 Jul 27;23(15)
International journal of molecular sciences 2022 Jul 27;23(15)
Phenylalanine impairs insulin signaling and inhibits glucose uptake through modification of IRβ.
Zhou Q, Sun WW, Chen JC, Zhang HL, Liu J, Lin Y, Lin PC, Wu BX, An YP, Huang L, Sun WX, Zhou XW, Li YM, Yuan YY, Zhao JY, Xu W, Zhao SM
Nature communications 2022 Jul 25;13(1):4291
Nature communications 2022 Jul 25;13(1):4291
Exposure to Bisphenol A Caused Hepatoxicity and Intestinal Flora Disorder in Rats.
Liu R, Liu B, Tian L, Jiang X, Li X, Cai D, Sun J, Bai W, Jin Y
International journal of molecular sciences 2022 Jul 21;23(14)
International journal of molecular sciences 2022 Jul 21;23(14)
Resveratrol Improves Synaptic Plasticity in Hypoxic-Ischemic Brain Injury in Neonatal Mice via Alleviating SIRT1/NF-κB Signaling-Mediated Neuroinflammation.
Peng X, Wang J, Peng J, Jiang H, Le K
Journal of molecular neuroscience : MN 2022 Jan;72(1):113-125
Journal of molecular neuroscience : MN 2022 Jan;72(1):113-125
G0S2 ameliorates oxidized low-density lipoprotein-induced vascular endothelial cell injury by regulating mitochondrial apoptosis.
Liang Z, Diao W, Jiang Y, Zhang Y
Annals of translational medicine 2022 Dec;10(24):1383
Annals of translational medicine 2022 Dec;10(24):1383
The vesicular transporter STX11 governs ATGL-mediated hepatic lipolysis and lipophagy.
Zhang G, Han J, Wang L, Yang X, Yan Z, Qu M, Zhou H, Bilal H, Wang F, Ge H, Yang X
iScience 2022 Apr 15;25(4):104085
iScience 2022 Apr 15;25(4):104085
Ginsenoside CK Inhibits TGF-β-Induced Epithelial-Mesenchymal Transition in A549 Cell via SIRT1.
Sun M, Zhuang X, Lv G, Lin Z, Huang X, Zhao J, Lin H, Wang Y
BioMed research international 2021;2021:9140191
BioMed research international 2021;2021:9140191
miR-539 Targeting SNAI2 Regulates MMP9 Signaling Pathway and Affects Blood-Brain Barrier Permeability in Cerebrovascular Occlusive Diseases: A Study Based on Head and Neck Ultrasound and CTA.
Li H, Han G, He D, Wang Y, Lin Y, Zhang T, Wang J, Du Y, Li G, Wang Y, Zhou J, Liu B
Journal of healthcare engineering 2021;2021:5699025
Journal of healthcare engineering 2021;2021:5699025
Acetyl-CoA synthases are essential for maintaining histone acetylation under metabolic stress during zygotic genome activation in pigs.
Zhou W, Nie ZW, Zhou DJ, Cui XS
Journal of cellular physiology 2021 Oct;236(10):6948-6962
Journal of cellular physiology 2021 Oct;236(10):6948-6962
Aronia melanocarpa polysaccharide ameliorates inflammation and aging in mice by modulating the AMPK/SIRT1/NF-κB signaling pathway and gut microbiota.
Zhao Y, Liu X, Zheng Y, Liu W, Ding C
Scientific reports 2021 Oct 18;11(1):20558
Scientific reports 2021 Oct 18;11(1):20558
Maternally expressed 3 protects the intestinal barrier from cardiac arrest-induced ischemia/reperfusion injury via miR-34a-3p/sirtuin 1/nuclear factor kappa B signaling.
Huang X, Pan M, Du P, Chen Y, Zhang C, Lu W, Lin J
Annals of translational medicine 2021 Jan;9(2):122
Annals of translational medicine 2021 Jan;9(2):122
Endurance Exercise-Induced Autophagy/Mitophagy Coincides with a Reinforced Anabolic State and Increased Mitochondrial Turnover in the Cortex of Young Male Mouse Brain.
Kwon I, Jang Y, Lee Y
Journal of molecular neuroscience : MN 2021 Jan;71(1):42-54
Journal of molecular neuroscience : MN 2021 Jan;71(1):42-54
Melatonin protects mouse testes from palmitic acid-induced lipotoxicity by attenuating oxidative stress and DNA damage in a SIRT1-dependent manner.
Xu D, Liu L, Zhao Y, Yang L, Cheng J, Hua R, Zhang Z, Li Q
Journal of pineal research 2020 Nov;69(4):e12690
Journal of pineal research 2020 Nov;69(4):e12690
Resveratrol Attenuates Aortic Dissection by Increasing Endothelial Barrier Function Through the SIRT1 Pathway.
Wang K, Zhao J, Zhang W, Zhu M, Xu M, Li D, Shi H, Zhang M, Shi J, Dong Z
Journal of cardiovascular pharmacology 2020 Jul;76(1):86-93
Journal of cardiovascular pharmacology 2020 Jul;76(1):86-93
Ameliorative effects and mechanism of crocetin in arsenic trioxide‑induced cardiotoxicity in rats.
Zhao Z, Li J, Zheng B, Liang Y, Shi J, Zhang J, Han X, Chu L, Chu X, Gao Y
Molecular medicine reports 2020 Dec;22(6):5271-5281
Molecular medicine reports 2020 Dec;22(6):5271-5281
TP53 mutation influences the efficacy of treatment of colorectal cancer cell lines with a combination of sirtuin inhibitors and chemotherapeutic agents.
Yang H, Chen Y, Jiang Y, Wang D, Yan J, Zhou Z
Experimental and therapeutic medicine 2020 Aug;20(2):1415-1422
Experimental and therapeutic medicine 2020 Aug;20(2):1415-1422
Catalytic-independent neuroprotection by SIRT1 is mediated through interaction with HDAC1.
Pfister JA, Ma C, D'Mello SR
PloS one 2019;14(4):e0215208
PloS one 2019;14(4):e0215208
SIRT1 protects against urban particulate matter-induced airway inflammation.
Lai T, Wen X, Wu D, Su G, Gao Y, Chen C, Wu W, Lv Y, Chen Z, Lv Q, Li W, Li D, Chen M, Wu B
International journal of chronic obstructive pulmonary disease 2019;14:1741-1752
International journal of chronic obstructive pulmonary disease 2019;14:1741-1752
SIRT1-regulated HMGB1 release is partially involved in TLR4 signal transduction: A possible anti-neuroinflammatory mechanism of resveratrol in neonatal hypoxic-ischemic brain injury.
Le K, Chibaatar Daliv E, Wu S, Qian F, Ali AI, Yu D, Guo Y
International immunopharmacology 2019 Oct;75:105779
International immunopharmacology 2019 Oct;75:105779
Microglia Activated by Excess Cortisol Induce HMGB1 Acetylation and Neuroinflammation in the Hippocampal DG Region of Mice Following Cold Exposure.
Xu B, Lang LM, Li SZ, Guo JR, Wang JF, Yang HM, Lian S
Biomolecules 2019 Aug 30;9(9)
Biomolecules 2019 Aug 30;9(9)
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 60303-1-Ig( SIRT1 Antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-SIRT1 (IP:60303-1-Ig, 5ug; Detection:60303-1-Ig 1:1000) with HeLa cells lysate 2000ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The SIRT1 antibody from Proteintech is a mouse monoclonal antibody to a recombinant protein of human SIRT1. This antibody recognizes human antigen. The SIRT1 antibody has been validated for the following applications: ELISA, WB, IHC, IP analysis.
