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- Product number
- 13161-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13161-1-AP, RRID:AB_10646436
- Product name
- SIRT1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated SIRT1 antibody (Cat. #13161-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Combined polyphenols in Psidium guajava-citrus limon leaf extract attenuate fructose-induced cardiac injury by modulating metabolic and oxidative stress pathways in rats.
4-Methylesculetin Ameliorates Hepatic Insulin Resistance in HepG2 Cells Through AMPK/FOXO1, PI3K/AKT/GSK3β Pathways and SIRT1/NOX4 Axis.
H3K18 lactylation-mediated SPHK1-SIRT1 feedback loop accelerates pyroptosis of tubular epithelial cells in sepsis-associated acute kidney injury.
Lithospermic Acid Improves Doxorubicin-Induced Cardiomyopathy Through Sirtuin-3-Mediated Deacetylation of p53.
MED1 IDR deacetylation controls stress responsive genes through RNA Pol II recruitment.
Microglia Dld-K127 lactylation promotes Parkinson's disease via regulating the metabolism of lactate-pyruvate transformation.
Fermented Black Soybean and Dehulled Adlay Improve Metabolic Syndrome via AMPK-SIRT1 Activation and Gut Microbiota Modulation.
Genetic deletion of adenosine A(2A) receptors attenuates memory deterioration and alterations of synaptic plasticity and metabolic controllers in the hippocampus and prefrontal cortex of aged mice.
Atractylodes macrocephala Koidz. water extract alleviates exercise-induced fatigue by activating mitochondrial biogenesis via the PGC-1α/NRF1/TFAM axis.
METTL1-deficient mesenchymal stem cells protect against metabolic-associated fatty liver disease by increasing NAMPT secretion.
Melatonin Ameliorates decaBDE-Induced Autism-Relevant Behaviors Through Promoting SIRT1/SIRT3/FOXO3a-Dependent Mitochondrial Quality Control.
High-Intensity Interval Training Outperforms Moderate-Intensity Exercise in Hyperlipidemic ApoE⁻/⁻ Mice: A Molecular and Histological Comparison.
Allosteric activation of pyruvate carboxylase by Dracoflavan B(2) enhances endothelial energy metabolism to attenuate myocardial infarction.
Gastric bypass surgery improves lipid metabolism and mitochondrial function through the glutamate receptor Grin3a-mediated CaMKKβ/AMPK pathway in a rat model of type 2 diabetes.
Sepsis-Induced Liver Injury Mitigated by Isoferulic Acid Through Inhibition of Hepatic Ferroptosis via the SIRT1 Signaling Pathway.
Metformin alleviates presbycusis by activating the SIRT1/PINK1/GPX4 pathway in vitro and in vivo.
Suppression of HIF-1α alleviates the symptoms associated with diabetic retinopathy in mice.
SIRT1 Regulates Iron Metabolism to Attenuate β-Cell Dedifferentiation by Inhibiting FoxO1 Acetylation.
Periplocin and bufalin induce cardiotoxicity by regulating AMPK/SIRT1/PGC-1α pathway to inhibit energy metabolism and trigger autophagy.
Nobiletin Ameliorates Skeletal Muscle Performance in D-Galactose-Induced Aging Mice by Boosting Aerobic Metabolism.
Renal-targeted exosomes inhibiting miR-182-5p for treatment of renal ischemia-reperfusion injury.
Sodium tanshinone IIA sulfonate alleviates neuroinflammation-induced damage to hippocampal neurons by activating SIRT1 in mice with sepsis-associated encephalopathy.
SIRT1 activation by SRT2104 enhances mitophagy and reduces senescence in auditory cells.
Shen-Shuai-II-Recipe inhibits aerobic glycolysis through SIRT1 in 5/6 ablation/infarction renal failure model.
Flavonoid-rich extracts of Nelumbo nucifera leaves alleviate obesity in HFD-fed mice via microbiota-dependent modulation of brown fat thermogenesis.
Lactate-mediated Ran lactylation at lysine 123 promotes astrocytes polarization after oxygen-glucose deprivation/reoxygenation.
Genistein Ameliorates the Ischemic State of Random Skin Flap by Regulating Macrophage Polarization Through AMPK/SIRT1 Signaling Pathway.
FGF2 Enhances MSCs Secretome Therapy for Skin Photoaging by Delaying Senescence via iNAMPT/AMPK Signaling and Facilitating eNAMPT-Mediated Regenerative Crosstalk.
High-fat diet mediates the formation of nonalcoholic fatty liver by modulating the AhR/miR-132/SIRT1 axis.
Cardiac PTN-SIRT1 axis alleviates oxidative stress and promotes mitochondrial energy reprogramming to mitigate doxorubicin-induced cardiotoxicity through AMPK/PGC1α signaling.
Ginsenoside Rb2 improves diminished ovarian reserve through regulation of gonadal hormones and apoptosis via SIRT1.
The SIRT1-Mediated p53 Deacetylation Pathway Modulates Apoptosis and Promotes Viral Replication in MVC-Infected Cells.
Preparation of Artemisia argyi-Derived Extracellular Nanovesicles and Their Protective Effects Against Oxidative Stress-Induced Senescence in Endometrial Stromal Cells.
ANGPT2/Tie2 Enhances H3K18la-Mediated Macrophage M2 Polarization to Promote Endothelial Cell Proliferation in the Chronically Ischaemic Brain.
Disruption of the SIRT1/PI3K/AKT Signaling Axis Mediates Fluoride-Induced Cardiotoxicity: Evidence from in Vitro and Zebrafish Models.
Delactylation of viral proteins by SIRT1 suppresses influenza A virus replication.
Pretreatment with a ketogenic diet inhibits mitochondrial damage in rat models of spinal cord injury via the PGC-1α/Sirt1/Nrf1 pathway.
N (1)-methylnicotinamide promotes age-related cochlear damage via the overexpression of SIRT1.
4'-Methoxyresveratrol Improves Hepatic Insulin Resistance Induced by a High-Fat-Diet via Anti-Oxidative-Stress Activity.
Integrated network pharmacology and experimental verification to reveal the mechanisms of curcumin in the treatment of colorectal cancer.
Cardiac protection of wogonin in mice with pulmonary fibrosis by regulating Sirt1/ γ-H2AX pathway.
Alisol A ameliorates vascular cognitive impairment via AMPK/NAMPT/SIRT1-mediated regulation of cholesterol and autophagy.
The Effects of M2 Macrophages-Derived Exosomes on Urethral Fibrosis and Stricture in Scar Formation.
Claudin-1 impairs blood-brain barrier by downregulating endothelial junctional proteins in traumatic brain injury.
Ozone water enema activates SIRT1-Nrf2/HO-1 pathway to ameliorate gut dysbiosis in mice receiving COVID-19 patient-derived faecal microbiota.
Agomelatine alleviates palmitic acid-induced mouse oocyte meiosis defects by restoring mitochondrial function.
The Role of SIRT1-BDNF Signaling Pathway in Fluoride-Induced Toxicity for Glial BV-2 Cells.
Flavonoids in Rosa roxburghii Tratt Fermentation Broth Ameliorate Obesity via DNMT3a/SIRT1-Mediated Epigenetic Modulation.
Salidroside protects bovine hepatocytes against fatty acid-induced lipid accumulation and inflammation by activating AMPK/SIRT1 pathway.
Effects of Tributyrin on Antioxidant Capacity, Immune Function, and Liver Macrophage Polarization in Weaned Piglets Under LPS Challenge.
Gut microbiota modified by Mulberry leaf water extract improves T2DM through browning of WAT/BAT activation mediated by SCFAs-AMPK/SIRT1/PGC-1α signaling pathway.
Self-assembled cyanidin-3-O-glucoside nanoparticles alleviate inflammation and ferroptosis induced by PRRSV infection.
Melatonin attenuates ischemia-reperfusion-induced acute kidney injury by regulating abnormal autophagy and pyroptosis through SIRT1-mediated p53 deacetylation.
Celastrol modulates IRS1 expression to alleviate ovarian aging and to enhance follicular development.
The Role of Sirt1 in Regulating Inflammatory Cytokines and Oxidative Stress in the Transition Mechanism from Depressive Disorder to Alzheimer's Disease.
Combination of imeglimin and resistance exercise improves mitochondrial function and glucose metabolism in skeletal muscles.
SIRT1 Expression in Human Gastrointestinal Tumors and Its Clinical Significance.
LncRNA-like MMP14 RNA facilitates colorectal cancer metastasis by suppressing H3K27cr at the STARD13 promoter region.
Luteoloside alleviates bleomycin-induced pulmonary fibrosis in mice via SIRT1-mediated protective effect against alveolar epithelial cell senescence.
Trace element-dictated exosome modules and self-adaptive dual-network hydrogel orchestrate diabetic foot regeneration through complement-mitochondria-autophagy circuitry.
Yunnan Baiyao regulates Th17/Treg cell homeostasis to inhibit periodontitis through the miR-155-5p/ATG5 pathway.
PACAP inhibits high fat-induced NLRP3 inflammasome-mediated pyroptosis in vascular endothelial cells by regulating the SIRT1/ROS pathway.
Disruption of ovarian function and induction of apoptosis in female mice by Brefeldin A: Mechanistic insights into reproductive toxicity.
Deacetylase SIRT1 modulates antiviral innate immunity and autoimmune diseases.
Inhibition of SIRT1/PGC-1α Axis Exacerbates Fluorine and Aluminium Induced Neurotoxicity via Drp1-dependent Aggravated Mitochondrial Fission.
Multi-Target Botanical Complex Attenuates Cellular Senescence via Bidirectional P21/P53/SIRT1 Regulation: Dual Model Validation.
Flavonoids from Rosa roxburghii Tratt fermentation broth inhibit adipogenesis via the SIRT1 pathway: insights from metabolomics and network pharmacology.
Metformin mitigates cisplatin-induced premature ovarian insufficiency via Sirt1/Nrf2 activation.
Hyperosmolarity-Induced Oxidative Stress Leads to Senescence in Human Corneal Epithelial Cells (HCEPC) via DNA Damage, Metabolic Disturbance and Mitophagy Decline.
SIRT1 Alleviates Oxidative Stress-Induced Mitochondrial Dysfunction and Mitochondria-Associated Membrane Dysregulation in Stress Urinary Incontinence.
Lycium ruthenicum Murray Anthocyanins Alleviate Aging Through SIRT1/P53 Signaling Pathway.
Human umbilical cord mesenchymal stem cell-derived exosomes repair IBD by activating the SIRT1-FXR pathway in macrophages.
Dual-responsive nanoparticles targeting ACE-II senescence for therapeutic mitigation of acute lung injury.
Hepatic sphingomyelin phosphodiesterase 3 promotes steatohepatitis by disrupting membrane sphingolipid metabolism.
Insights into the potential role of BMSCs-exo delivered USP14 on SIRT1 deubiquitination in Staphylococcus aureus-induced model of osteomyelitis.
NUDT21 lactylation reprograms alternative polyadenylation to promote cuproptosis resistance.
Xiasangju alleviates hepatic insulin resistance in db/db mice via AMPK pathway: Mechanisms and active components study.
Inhibition of CDK5 signaling mediated inflammation in macrophages promotes cutaneous wound healing.
Bufei Yishen formula alleviates airway epithelial cell senescence in COPD by activating AMPK-Sirt1-FoxO3a pathway and promoting autophagy.
Delta Opioid Peptide [d-Ala2, d-Leu5]-Enkephalin Improves Physical and Cognitive Function and Increases Lifespan in Aged Female Mice.
Exercise-induced Activation of SIRT1/BDNF/mTORC1 Signaling Pathway: A Novel Mechanism to Reduce Neuroinflammation and Improve Post-stroke Depression.
The potential role of the SIRT1-Nrf2 signaling pathway in alleviating hidden hearing loss via antioxidant stress.
Panax ginseng exerts cardioprotective effect post myocardial infarction by attenuating myocardial fibrosis and inflammation through SIRT1 signaling pathways.
Anti-fibrosis effect and its mechanism of atractylenolide III on post-traumatic extending knee joint contracture in rats.
Sirtuin-2 Is Involved in the Regulation of Claudin-4 Expression and Paracellular Barrier Function in Keratinocytes.
miR-138-5p inhibits healing of femoral fracture osteogenesis in rats by modulating osteoblast differentiation via SIRT1/FOXO1 axis.
Apoptotic vesicles derived from bone marrow mesenchymal stem cells increase angiogenesis in a hind limb ischemia model via the NAMPT/SIRT1/FOXO1 axis.
5-Demethyl-Polymethoxyflavones Mitigate Obesity by Reducing Adipose Tissue Inflammation, Promoting Browning, and Modulating Gut Microbiota in High-Fat Diet-Fed Mice.
Inhibition of SIRT1/HSF1 pathway contributes to doxorubicin-induced nephrotoxicity in ovarian tumor-bearing mice.
Ginsenoside Rk1 Ameliorates Non-Alcoholic Fatty Liver Disease by Targeting CD36 to Modulate the AMPK Signaling Pathway.
Cardioprotective effects of the jiming formula on myocardial metabolism in Mice with myocardial infarction via the AMPK/SIRT1/PGC-1α pathway.
Pelargonidin-3-O-galactoside Alleviates Acute Lung Injury Induced by Klebsiella pneumoniae by Targeting CD38-Mediated Pyroptosis.
Initiating Empagliflozin and Sacubitril/Valsartan Early After Acute Myocardial Infarction: Mechanistic Study.
Time Does Matter: The Cellular Response to Resveratrol Varies Depending on the Exposure Duration.
Sevoflurane: A dual modulator of miR‑211‑5p and mitochondrial apoptosis in glioma therapy.
Alpha-lipoamide prevents acute kidney injury in mouse by inhibiting renal tubular epithelial cell pyroptosis.
Scutellarein ameliorates pulmonary arterial hypertension via sirtuin 1 mediated deacetylation of nicotinamide nucleotide transhydrogenase.
Systematic pharmacology and experimental validation revealed the mechanism of Bupleurum chinense DC -mediated autophagy in alleviating osteoarthritis.
Buzhong Yiqi decoction improves inflammation and oxidative damage in autoimmune thyroiditis by inhibiting apoptosis via the SIRT1-Mediated Nrf2/NF-κB axis.
Trigonelline attenuated sepsis-induced acute kidney injury by activating NAD+/SIRT1 Pathway.
Erythropoietin (EPO) Alleviates Chronic Stress-Induced Depression by Modulating SIRT1-Mediated Mitochondrial Function.
Exogenous H(2)S reduces oxidative stress induced by lipid mixture in HepG2 cells through USP22/SIRT1 axis.
Nicotinamide riboside promoted cardiac energetics and alleviated doxorubicin-induced cardiotoxicity via SIRT1/ERRα signal in human pluripotent stem cells-derived cardiomyocytes.
USP7 promotes PINK1/Parkin-dependent mitophagy to ameliorate cerebral ischemia-reperfusion injury by deubiquitinating and stabilizing SIRT1.
Human HDAC6 senses valine abundancy to regulate DNA damage.
Melatonin protects porcine oocytes from gossypol-induced meiosis defects via regulation of SIRT1-mediated mitophagy.
LncRNA HOXB3OS improves high glucose-mediated podocyte damage and progression of diabetic kidney disease through enhancing SIRT1 mRNA stability.
Delphinidin or α-amyrin attenuated liver steatosis and metabolic disarrangement in rats fed a high-fat diet.
MiR-128-3p promotes hyperproliferation of keratinocytes and psoriasis-like inflammation by targeting SIRT1/HIF-1α.
Fatty Acid Esterification of Octacosanol Attenuates Triglyceride and Cholesterol Synthesis in Mice.
Sirtuin-1 Regulates Mitochondrial Calcium Uptake Through Mitochondrial Calcium Uptake 1 (MICU1).
Mesoporous Prussian blue nanoparticle neuroconduit for the biological therapy targeting oxidative stress reduction, inflammation inhibition, and nerve regeneration.
Therapeutic Effects of GDF6-Overexpressing Mesenchymal Stem Cells through Upregulation of the GDF15/SIRT1 Axis in Age-Related Hearing Loss.
Puerarin reduces diabetic nephropathy-induced podocyte pyroptosis by modulating the SIRT1/NLRP3/caspase-1 pathway.
Inhalation exposure to airborne PM(2.5) attenuates hepatic metabolic pathways through S-nitrosylation of the primary ER stress sensor.
Melatonin alleviates oxidative stress and inflammation of Leydig cells of Min pig through SIRT1 pathway.
Aptamer-Conjugated Exosomes Ameliorate Diabetes-Induced Muscle Atrophy by Enhancing SIRT1/FoxO1/3a-Mediated Mitochondrial Function.
Hydroxysafflor yellow A attenuates the inflammatory response in cerebral ischemia-reperfusion injured mice by regulating microglia polarization per SIRT1-mediated HMGB1/NF-κB signaling pathway.
Ergothioneine improves healthspan of aged animals by enhancing cGPDH activity through CSE-dependent persulfidation.
Ribes diacanthum Pall modulates bile acid homeostasis and oxidative stress in cholestatic mice by activating the SIRT1/FXR and Keap1/Nrf2 signaling pathways.
Puerarin reduces susceptibility to ventricular arrhythmias and inhibits ferroptosis via Sirt1/Nrf2 signaling in high-fat-diet rats.
NAD(+) Enhanced Mesenchymal Stromal Cells Effect on Muscle Atrophy by Improving SIRT1-Mediated Mitochondrial Function via NAMPT.
Hesperidin Reverses Oxidative Stress-Induced Damage in Kidney Cells by Modulating Antioxidant, Longevity, and Senescence-Related Genes.
Effect of Food Migrations of PEEK-Modified Atmosphere Packaging Materials on Mitochondrial Damage via PGC-1α/Nrf2 Signaling Pathway.
The Ku80-p53-SIRT1 axis in DNA damage response contributes to sporadic and familial ALS and FTD.
Role of Esketamine in Attenuating Neuroinflammation and Improving Postoperative Cognitive Function via Autophagy Activation Through PARP1 Targeting.
Exploring neuroprotective effects of Chuanzhitongluo capsule on an alzheimer's disease rat model.
Interleukin 13 alleviates traumatic brain injury by promoting pericyte autophagy.
Sirt1 attenuates necrotizing enterocolitis via Hif-1α deacetylation-mediated suppression of Bnip3-Dependent mitophagy.
Phosphorylation of PA28γ by CK2 kinase facilitates HNSCC tumor formation and progression.
Liraglutide attenuates high glucose-induced endothelial cell senescence and dysfunction via SIRT1-mediated deacetylation of p53/p65.
Improvement effect of Shengxian Decoction on cardiac toxicity induced by arsenic trioxide in rats.
RhFGF21 protects the skin from UVB irradiation in diabetic mice through the inhibition of epidermal cell apoptosis and macrophage-mediated inflammation via the SIRT1 signaling pathway.
New insights into ovarian regression-related mitochondrial dysfunction in the late-laying period.
Loss of NgBR causes neuronal damage through decreasing KAT7-mediated RFX1 acetylation and FGF1 expression.
LNCAROD was stabilized through N(6)-methyladenosine methylation and exerted its anticancer effects in lung squamous cell carcinoma by inhibiting SIRT1 activity via CCAR2.
Synergistic mechanism of olaparib and cisplatin on breast cancer elucidated by network pharmacology.
TACC3 enhances glycolysis in bladder cancer cells through inducing acetylation of c-Myc.
Nicotinamide mononucleotide promotes female germline stem cell proliferation by activating the H4K16ac-Hmgb1-Fyn-PLD signaling pathway through epigenetic remodeling.
Nicotinamide ameliorates podocyte injury and albuminuria in adriamycin-induced nephropathy.
Young TSPC-Derived Exosomal circPVT1 Ameliorates Aging-Impaired Cell Function via SIRT1/NF-κB.
Forsythoside B alleviates cerebral ischemia-reperfusion injury via inhibiting NLRP3 inflammasome mediated by SIRT1 activation.
Jagged 2 inhibition attenuates hypoxia-induced mitochondrial damage and pulmonary hypertension through Sirtuin 1 signaling.
Integrated Network Pharmacology and in vivo Experimental Validation Approach to Explore the Potential Antioxidant Effects of Annao Pingchong Decoction in Intracerebral Hemorrhage Rats.
Inflammation Can Be a High-Risk Factor for Mucosal Nonunion of MRONJ by Regulating SIRT1 Signaling When Treated with an Oncologic Dose of Zoledronate.
NAD-Dependent Protein Deacetylase Sirtuin-1 Mediated Mitophagy Regulates Early Brain Injury After Subarachnoid Hemorrhage.
Diosgenin derivative ML5 attenuates MPTP-induced neuronal impairment via regulating AMPK/PGC-1α-mediated mitochondrial biogenesis and fusion/fission.
Inhibition SIRT1 to regulate FOXP3 or RORγt can restore the balance of Treg/Th17 axis in ulcerative colitis and enhance the anti-inflammatory effect of moxibustion.
The role of SIRT1-FXR signaling pathway in valproic acid induced liver injury: a quantitative targeted metabolomic evaluation in epileptic children.
The mitochondria‒paraspeckle axis regulates the survival of transplanted stem cells under oxidative stress conditions.
Nicorandil mitigates arsenic trioxide-induced lung injury via modulating vital signalling pathways SIRT1/PGC-1α/TFAM, JAK1/STAT3, and miRNA-132 expression.
Aspirin exposure coupled with hypoxia interferes energy metabolism, antioxidant and autophagic processes and causes liver injury in estuarine goby Mugilogobius chulae.
BAP1 regulates HSF1 activity and cancer immunity in pancreatic cancer.
LINC00887 promotes GCN5-dependent H3K27cr level and CRC metastasis via recruitment of YEATS2 and enhancing ETS1 expression.
Melatonin Regulates the Expression of VEGF and HOXA10 in Bovine Endometrial Epithelial Cells through the SIRT1/PI3K/AKT Pathway.
Sirtuin 1 Inhibits Fatty Acid Synthesis through Forkhead Box Protein O1-Mediated Adipose Triglyceride Lipase Expression in Goat Mammary Epithelial Cells.
Unveiling the regulatory role of SIRT1 in the oxidative stress response of bovine mammary cells.
The transcription factor PPARA mediates SIRT1 regulation of NCOR1 to protect damaged heart cells.
Human adipose and umbilical cord mesenchymal stem cell-derived extracellular vesicles mitigate photoaging via TIMP1/Notch1.
Luteolin Protects against Vascular Calcification by Modulating SIRT1/CXCR4 Signaling Pathway and Promoting Autophagy.
Black phosphorus nanosheets induce autophagy dysfunction by a size- and surface modification-related impairment of lysosomes in macrophages.
Discovery of SIRT1-Activating Hydrogen Sulfide Donating Derivatives for Efficient Resistant of Myocardial Ischemic Injury.
Exploring the Effects of Whole Food-Based Dragon Fruit on Metabolic Disorders in High-Fat Diet-Induced Mice.
SIRT1, a target of miR-708-3p, alleviates fluoride-induced neuronal damage via remodeling mitochondrial network dynamics.
6-Gingerol improves lipid metabolism disorders in skeletal muscle by regulating AdipoR1/AMPK signaling pathway.
Resistance Exercise Improves Glycolipid Metabolism and Mitochondrial Biogenesis in Skeletal Muscle of T2DM Mice via miR-30d-5p/SIRT1/PGC-1α Axis.
Tat-Beclin-1 Peptide Ameliorates Metabolic Dysfunction-Associated Steatotic Liver Disease by Enhancing Hepatic Autophagy.
Acetylation of FOXO1 is involved in cadmium-induced rat kidney injury via mediating autophagosome-lysosome fusion blockade and autophagy inhibition.
Taraxerone inhibits M1 polarization and alleviates sepsis-induced acute lung injury by activating SIRT1.
SIRT1-Dependent Neuroprotection by Resveratrol in TOCP-Induced Spinal Cord Injury: Modulation of ER Stress and Autophagic Flux.
Hydrogen sulfide upregulates SIRT1 to inhibit ox-HDL-induced endothelial cell damage and mitochondrial dysfunction.
Myricanol improves metabolic profiles in dexamethasone induced lipid and protein metabolism disorders in mice.
Rap1GAP exacerbates myocardial infarction by regulating the AMPK/SIRT1/NF-κB signaling pathway.
Development and Application of the CRISPR-dcas13d-eIF4G Translational Regulatory System to Inhibit Ferroptosis in Calcium Oxalate Crystal-Induced Kidney Injury.
Inhibition of SIRT1 in the nucleus accumbens attenuates heroin addiction-related behavior by decreasing D1 neuronal autophagy.
FTH1 overexpression using a dCasRx translation enhancement system protects the kidney from calcium oxalate crystal-induced injury.
Senegenin Attenuates Pulmonary Fibrosis by Inhibiting Oxidative-Stress-Induced Epithelial Cell Senescence through Activation of the Sirt1/Pgc-1α Signaling Pathway.
PM(2.5) induces cardiac defects via AHR-SIRT1-PGC-1α mediated mitochondrial damage.
Nicotine regulates abnormal macrophage polarization and trophoblast invasion associated with preterm labor via the α7nAChR/SIRT1 axis.
Curculigoside Attenuates Endoplasmic Reticulum Stress-Induced Epithelial Cell and Fibroblast Senescence by Regulating the SIRT1-P300 Signaling Pathway.
Caffeic acid phenethyl ester inhibits neuro-inflammation and oxidative stress following spinal cord injury by mitigating mitochondrial dysfunction via the SIRT1/PGC1α/DRP1 signaling pathway.
The Effectiveness of Four Nicotinamide Adenine Dinucleotide (NAD(+)) Precursors in Alleviating the High-Glucose-Induced Damage to Hepatocytes in Megalobrama amblycephala: Evidence in NAD(+) Homeostasis, Sirt1/3 Activation, Redox Defense, Inflammatory Response, Apoptosis, and Glucose Metabolism.
Deacetylase Sirtuin 1 mitigates type I IFN- and type II IFN-induced signaling and antiviral immunity.
MED1 IDR acetylation reorganizes the transcription preinitiation complex, rewires 3D chromatin interactions and reprograms gene expression.
BNC1 deficiency induces mitochondrial dysfunction-triggered spermatogonia apoptosis through the CREB/SIRT1/FOXO3 pathway: the therapeutic potential of nicotinamide riboside and metformin†.
Cluster of Differentiation-44-Targeting Prussian Blue Nanoparticles Onloaded with Colchicine for Atherosclerotic Plaque Regression in a Mice Model.
Acupuncture alleviates CUMS-induced depression-like behaviors of rats by regulating oxidative stress, neuroinflammation and ferroptosis.
Structural characterization and improves cognitive disorder in ageing mice of a glucomannan from Dendrobium huoshanense.
Glucose regulates the HMGB1 signaling pathway through SIRT1 in glioma.
Inhibiting Pink1/Parkin-mediated mitophagy enhances the anticancer effects of quercetin in hepatocellular carcinomaf.
Menaquinone-4 alleviates hypoxic-ischemic brain damage in neonatal rats by reducing mitochondrial dysfunction via Sirt1-PGC-1α-TFAM signaling pathway.
TBK1 pharmacological inhibition mitigates osteoarthritis through attenuating inflammation and cellular senescence in chondrocytes.
Carnosol prevents cardiac remodeling and ventricular arrhythmias in pressure overload-induced heart failure mice.
Taraxerone exerts antipulmonary fibrosis effect through Smad signaling pathway and antioxidant stress response in a Sirtuin1-dependent manner.
Mechanism Research of DHEA Treatment Improving Diminished Ovarian Reserve by Attenuating the AMPK-SIRT1 Signaling and Mitophagy.
miR-485-3p targets SIRT1 in vascular smooth muscle cells mediating the occurrence of aortic dissection.
Pinocembrin's protective effect against acute pancreatitis in a rat model: The correlation between TLR4/NF-κB/NLRP3 and miR-34a-5p/SIRT1/Nrf2/HO-1 pathways.
Luteolin alleviates cadmium-induced metabolism disorder through antioxidant and anti-inflammatory mechanisms in chicken kidney.
Dulaglutide restores endothelial progenitor cell levels in diabetic mice and mitigates high glucose-induced endothelial injury through SIRT1-mediated mitochondrial fission.
Ginsenoside Rb1 regulates CPT1A deacetylation to inhibit intramuscular fat infiltration after rotator cuff tear.
Weissella paramesenteroides NRIC1542 inhibits dextran sodium sulfate-induced colitis in mice through regulating gut microbiota and SIRT1/NF-κB signaling pathway.
Overexpression of SESN1 improves mitochondrial damage and mitophagy, a potential therapeutic strategy for cognitive dysfunction after anaesthesia.
Electroacupuncture ameliorates chronic unpredictable mild stress-induced depression-like behavior and cognitive impairment through suppressing oxidative stress and neuroinflammation in rats.
Protectin D1 ameliorates non-compressive lumbar disc herniation through SIRT1-mediated CGRP signaling.
TIMELESS promotes reprogramming of glucose metabolism in oral squamous cell carcinoma.
LncRNA HOTAIR regulates autophagy and proliferation mechanisms in premature ovarian insufficiency through the miR-148b-3p/ATG14 axis.
The promotion of fatty acid β-oxidation by hesperidin via activating SIRT1/PGC1α to improve NAFLD induced by a high-fat diet.
Quercetin stimulates trophoblast fusion via the mitochondrial function.
The SIRT1/Nrf2 signaling pathway mediates the anti-pulmonary fibrosis effect of liquiritigenin.
Decoupling NAD(+) metabolic dependency in chondrosarcoma by targeting the SIRT1-HIF-2α axis.
Tryptophanylation of insulin receptor by WARS attenuates insulin signaling.
Network pharmacology and experimental validation on yangjing zhongyu decoction against diminished ovarian reserve.
The role and mechanism of RIPK1 in vascular endothelial dysfunction in chronic kidney disease.
Safranal acts as a neurorestorative agent in rats with cerebral ischemic stroke via upregulating SIRT1.
Gestational exposure to bisphenol AF causes endocrine disorder of corpus luteum by altering ovarian SIRT-1/Nrf2/NF-kB expressions and macrophage proangiogenic function in mice.
Ginsenoside Rg5 inhibits lipid accumulation and hepatocyte apoptosis via the Notch1 signaling pathway in NASH mice.
Ginsenoside Rb1 prevents age-related endothelial senescence by modulating SIRT1/caveolin-1/enos signaling pathway.
Txnip promotes autophagic apoptosis in diabetic cardiomyopathy by upregulating FoxO1 and its acetylation.
CTRP6-mediated cardiac protection in heart failure via the AMPK/SIRT1/PGC-1α signalling pathway.
SIRT1 Activation Suppresses Corneal Endothelial-Mesenchymal Transition via the TGF-β/Smad2/3 Pathway.
Qianyang yuyin granule ameliorates mitochondrial dysfunction of hypertensive myocardial remodeling.
Efficacy of DHA-enriched phosphatidylserine and its underlying mechanism in alleviating polystyrene nanoplastics-induced hepatotoxicity in mice.
Bone-protective effects of neutralizing angiopoietin-like protein 4 monoclonal antibody in rheumatoid arthritis.
Long-term exposure to advanced lipid peroxidation end products impairs cognitive function through microbiota-gut-brain axis.
DEHP regulates ferritinophagy to promote testicular ferroptosis via suppressing SIRT1/PGC-1α pathway.
Dietary sodium sulphate supplementation during mid-to-late gestation improves placental angiogenesis, bile acid metabolism, and serum amino acid concentrations of sows.
1,8-cineole ameliorates experimental diabetic angiopathy by inhibiting NLRP3 inflammasome-mediated pyroptosis in HUVECs via SIRT2.
Phenylsulfate-induced oxidative stress and mitochondrial dysfunction in podocytes are ameliorated by Astragaloside IV activation of the SIRT1/PGC1α /Nrf1 signaling pathway.
Integrative Analysis of Lactylome and Proteome of Hypertrophic Scar To Identify Pathways or Proteins Associated with Disease Development.
Mesenchymal stromal cells ameliorate mitochondrial dysfunction in α cells and hyperglucagonemia in type 2 diabetes via SIRT1/FoxO3a signaling.
Diosgenin attenuates nonalcoholic hepatic steatosis through the hepatic SIRT1/PGC-1α pathway.
Berberine ameliorates contrast-induced acute kidney injury by regulating HDAC4-FoxO3a axis-induced autophagy: In vivo and in vitro.
Danggui Shaoyao San protects cyclophosphamide-induced premature ovarian failure by inhibiting apoptosis and oxidative stress through the regulation of the SIRT1/p53 signaling pathway.
Luteolin Alleviates Cadmium-Induced Kidney Injury by Inhibiting Oxidative DNA Damage and Repairing Autophagic Flux Blockade in Chickens.
Mechanism of ameliorating cerebral ischemia/reperfusion injury by antioxidant inhibition of autophagy based on network pharmacology and experimental verification.
IgG is an aging factor that drives adipose tissue fibrosis and metabolic decline.
Protective role of forsythoside B in Kawasaki disease-induced cardiac injury: Inhibition of pyroptosis via the SIRT1-NF-κB-p65 signaling pathway.
Apigenin delays postovulatory oocyte aging by reducing oxidative stress through SIRT1 upregulation.
LncRNA GAS5 restrains ISO-induced cardiac fibrosis by modulating mir-217 regulation of SIRT1.
Echinacoside alleviates airway remodeling and inflammation in an ovalbumin-induced neonatal mouse model of asthma by modulating the SIRT1-NF-κB pathway.
Triamcinolone acetonide induces the autophagy of Ag85B-treated WI-38 cells via SIRT1/FOXO3 pathway.
ESE-1 mediates lipopolysaccharide-induced BV2 cell inflammation via upregulation of HMGB1 expression.
Puromycin-induced kidney injury and subsequent regeneration in adult zebrafish.
Diet Control and Swimming Exercise Ameliorate HFD-Induced Cognitive Impairment Related to the SIRT1-NF-κB/PGC-1α Pathways in ApoE-/- Mice.
α-Mangostin Inhibited M1 Polarization of Macrophages/Monocytes in Antigen-Induced Arthritis Mice by Up-Regulating Silent Information Regulator 1 and Peroxisome Proliferators-Activated Receptor γ Simultaneously.
MiRNA-Seq reveals key MicroRNAs involved in fat metabolism of sheep liver.
Exercise prevents fatal stress-induced myocardial injury in obese mice.
Biomarker identification and pathway analysis of Astragalus membranaceus and Curcuma zedoaria couplet medicines on adenine-induced chronic kidney disease in rats based on metabolomics.
Pterostilbene Enhances Thermogenesis and Mitochondrial Biogenesis by Activating the SIRT1/PGC-1α/SIRT3 Pathway to Prevent Western Diet-Induced Obesity.
α-myosin heavy chain lactylation maintains sarcomeric structure and function and alleviates the development of heart failure.
Genetic modification of miR-34a enhances efficacy of transplanted human dental pulp stem cells after ischemic stroke.
Dendrobium officinale Kimura & Migo polysaccharide inhibits hyperglycaemia-induced kidney fibrosis via the miRNA-34a-5p/SIRT1 signalling pathway.
Baicalein ameliorates polymyxin B-induced acute renal injury by inhibiting ferroptosis via regulation of SIRT1/p53 acetylation.
A novel pyroptosis-associated lncRNA LINC01133 promotes pancreatic adenocarcinoma development via miR-30b-5p/SIRT1 axis.
PM2.5 mediates mouse testis Sertoli TM4 cell damage by reducing cellular NAD().
Effects of Gestational Hypoxia on PGC1α and Mitochondrial Acetylation in Fetal Guinea Pig Hearts.
Sirtuin1 Mediates the Protective Effects of Echinacoside against Sepsis-Induced Acute Lung Injury via Regulating the NOX4-Nrf2 Axis.
Dapagliflozin suppress endoplasmic reticulum stress mediated apoptosis of chondrocytes by activating Sirt1.
Shuangshi Tonglin capsule improves chronic prostatitis through the SIRT-1/AMPK and MAPK signalling pathways.
SIRT1-dependent mitochondrial biogenesis supports therapeutic effects of vidarabine against rotenone-induced neural cell injury.
Miquelianin in Folium Nelumbinis extract promotes white-to-beige fat conversion via blocking AMPK/DRP1/mitophagy and modulating gut microbiota in HFD-fed mice.
SIRT1-dependent mitochondrial biogenesis supports therapeutic effects of 4-butyl-polyhydroxybenzophenone compounds against NAFLD.
5-(3',4'-dihydroxyphenyl)-γ-valerolactone, a microbiota metabolite of flavan-3-ols, activates SIRT1-mediated autophagy to attenuate H₂O₂-induced inhibition of osteoblast differentiation in MC3T3-E1 cells.
Sirt1 protects against intervertebral disc degeneration induced by 1,25-dihydroxyvitamin D insufficiency in mice by inhibiting the NF-κB inflammatory pathway.
Naringin against doxorubicin-induced hepatotoxicity in mice through reducing oxidative stress, inflammation, and apoptosis via the up-regulation of SIRT1.
Resveratrol protects renal damages induced by periodontitis via preventing mitochondrial dysfunction in rats.
SZC-6, a small-molecule activator of SIRT3, attenuates cardiac hypertrophy in mice.
The mechanism of low-level arsenic exposure-induced hypertension: Inhibition of the activity of the angiotensin-converting enzyme 2.
Resveratrol reversed ambient particulate matter exposure-perturbed oscillations of hepatic glucose metabolism by regulating SIRT1 in mice.
Erxian decoction alleviates cisplatin-induced premature ovarian failure in rats by reducing oxidation levels in ovarian granulosa cells.
N(6)-methyladenosine of Spi2a attenuates inflammation and sepsis-associated myocardial dysfunction in mice.
Phosphoglycerate dehydrogenase activates PKM2 to phosphorylate histone H3T11 and attenuate cellular senescence.
Neonatal exposure to low-dose X-ray causes behavioral defects and abnormal hippocampal development in mice.
miR-484 mediates oxidative stress-induced ovarian dysfunction and promotes granulosa cell apoptosis via SESN2 downregulation.
METTL3-mediated m6A modification of SIRT1 mRNA inhibits progression of endometriosis by cellular senescence enhancing.
β-Nicotinamide mononucleotide activates NAD+/SIRT1 pathway and attenuates inflammatory and oxidative responses in the hippocampus regions of septic mice.
Hydrogen sulfide attenuates TMAO‑induced macrophage inflammation through increased SIRT1 sulfhydration.
Silicate ions as soluble form of bioactive ceramics alleviate aortic aneurysm and dissection.
Astragaloside IV ameliorates cognitive impairment and protects oligodendrocytes from antioxidative stress via regulation of the SIRT1/Nrf2 signaling pathway.
Mulberry leaves attenuate D-galactose-induced aging in vivo and in vitro.
Down-regulated Smyd1 participated in the inhibition of myoblast differentiation induced by cigarette smoke extract.
Dietary leucine and fish oil cooperatively regulate skeletal myofiber type transformation via the CaMKII signaling pathway of pigs.
Platelet-derived extracellular vesicles ameliorate intervertebral disc degeneration by alleviating mitochondrial dysfunction.
Melatonin alleviates BDE-209-induced cognitive impairment and hippocampal neuroinflammation by modulating microglia polarization via SIRT1-mediated HMGB1/TLR4/NF-κB pathway.
Selenium alleviates cadmium-induced mitophagy through FUNDC1-mediated mitochondrial quality control pathway in the lungs of sheep.
Quercetin alleviates lipopolysaccharide‑induced acute lung injury by inhibiting ferroptosis via the Sirt1/Nrf2/Gpx4 pathway.
miR-653-3p promotes genomic instability of colorectal cancer cells via targeting SIRT1/TWIST1 signaling pathway.
Decreased SIRT1 mRNA expression in peripheral blood mononuclear cells from patients with neuromyelitis optica spectrum disorders.
7,8,3'-Trihydroxyflavone prevents doxorubicin-induced cardiotoxicity and mitochondrial dysfunction via activating Akt signaling pathway in H9c2 cells.
Didymin alleviates metabolic dysfunction-associated fatty liver disease (MAFLD) via the stimulation of Sirt1-mediated lipophagy and mitochondrial biogenesis.
Resveratrol Improves the Frozen-Thawed Ram Sperm Quality.
Paeoniflorin recued hepatotoxicity under zinc oxide nanoparticles exposure via regulation on gut-liver axis and reversal of pyroptosis.
Polystyrene exacerbates cadmium-induced mitochondrial damage to lung by blocking autophagy in mice.
Exogenous hydrogen sulfide alleviates hepatic endoplasmic reticulum stress via SIRT1/FoxO1/PCSK9 pathway in NAFLD.
Tanshinone IIA ameliorates experimental diabetic cardiomyopathy by inhibiting endoplasmic reticulum stress in cardiomyocytes via SIRT1.
Inhibition of SIRT1 promotes ultraviolet B induced cataract via downregulation of the KEAP1/NFE2L2 signaling pathway.
Salidroside alleviates oxidative stress in dry eye disease by activating autophagy through AMPK-Sirt1 pathway.
Salidroside ameliorates acetaminophen-induced acute liver injury through the inhibition of endoplasmic reticulum stress-mediated ferroptosis by activating the AMPK/SIRT1 pathway.
Salidroside alleviates acetaminophen-induced hepatotoxicity via Sirt1-mediated activation of Akt/Nrf2 pathway and suppression of NF-κB/NLRP3 inflammasome axis.
Intermittent fasting activates macrophage migration inhibitory factor and alleviates high-fat diet-induced nonalcoholic fatty liver disease.
Astaxanthin promotes mitochondrial biogenesis and antioxidant capacity in chronic high-intensity interval training.
MiR-155 promotes inflammation and apoptosis via targeting SIRT1 in hypoxic-ischemic brain damage.
Syndecan-3 Coregulates Milk Fat Metabolism and Inflammatory Reactions in Bovine Mammary Epithelial Cells through AMPK/SIRT1 Signaling Pathway.
Salvianolic Acid A Protects against Acetaminophen-Induced Hepatotoxicity via Regulation of the miR-485-3p/SIRT1 Pathway.
Nuclear ATR lysine-tyrosylation protects against heart failure by activating DNA damage response.
High-Dosage NMN Promotes Ferroptosis to Suppress Lung Adenocarcinoma Growth through the NAM-Mediated SIRT1-AMPK-ACC Pathway.
Gandi Capsule Improved Podocyte Lipid Metabolism of Diabetic Nephropathy Mice through SIRT1/AMPK/HNF4A Pathway.
Catalpol Enhances Random-Pattern Skin Flap Survival by Activating SIRT1-Mediated Enhancement of Autophagy.
Fluorofenidone Inhibits UUO/IRI-Induced Renal Fibrosis by Reducing Mitochondrial Damage.
Electroacupuncture Pretreatment Exhibits Lung Protective and Anti-Inflammation Effects in Lipopolysaccharide-Induced Acute Lung Injury via SIRT1-Dependent Pathways.
∆nFGF1 Protects β-Cells against High Glucose-Induced Apoptosis via the AMPK/SIRT1/PGC-1α Axis.
Atractylenolide III ameliorates Non-Alcoholic Fatty Liver Disease by activating Hepatic Adiponectin Receptor 1-Mediated AMPK Pathway.
Photobiomodulation promotes repair following spinal cord injury by restoring neuronal mitochondrial bioenergetics via AMPK/PGC-1α/TFAM pathway.
Melatonin promotes sirtuin 1 expression and inhibits IRE1α-XBP1S-CHOP to reduce endoplasmic reticulum stress-mediated apoptosis in chondrocytes.
Protective effect of Astragaloside IV on chronic intermittent hypoxia-induced vascular endothelial dysfunction through the calpain-1/SIRT1/AMPK signaling pathway.
Chitosan/Sodium Alginate/Velvet Antler Blood Peptides Hydrogel Promoted Wound Healing by Regulating PI3K/AKT/mTOR and SIRT1/NF-κB Pathways.
Antisense Oligonucleotide-Based Therapy on miR-181a-5p Alleviates Cartilage Degradation of Temporomandibular Joint Osteoarthritis via Promoting SIRT1.
Sleeve Gastrectomy-Induced AMPK Activation Attenuates Diabetic Cardiomyopathy by Maintaining Mitochondrial Homeostasis via NR4A1 Suppression in Rats.
Cold Exposure Induces Intestinal Barrier Damage and Endoplasmic Reticulum Stress in the Colon via the SIRT1/Nrf2 Signaling Pathway.
Involvement of the SIRT1/PGC-1α Signaling Pathway in Noise-Induced Hidden Hearing Loss.
Mouse promyelocytic leukemia zinc finger protein (PLZF) regulates hepatic lipid and glucose homeostasis dependent on SIRT1.
Yinchen Linggui Zhugan decoction ameliorates high fat diet-induced nonalcoholic fatty liver disease by modulation of SIRT1/Nrf2 signaling pathway and gut microbiota.
Small extracellular vesicle-associated miR-6068 promotes aggressive phenotypes of prostate cancer through miR-6068/HIC2/SIRT1 axis.
Naringenin regulates gut microbiota and SIRT1/ PGC-1ɑ signaling pathway in rats with letrozole-induced polycystic ovary syndrome.
Glutamine in suppression of lipopolysaccharide-induced piglet intestinal inflammation: The crosstalk between AMPK activation and mitochondrial function.
SUMOylation of SIRT1 activating PGC-1α/PPARα pathway mediates the protective effect of LncRNA-MHRT in cardiac hypertrophy.
SIRT1 modifies DNA methylation linked to synaptic deficits induced by Pb in vitro and in vivo.
Yangjing Zhongyu decoction facilitates mitochondrial activity, estrogenesis, and energy metabolism in H(2)O(2)-induced human granulosa cell line KGN.
Anti-inflammatory potential of stevia residue extract against uric acid-associated renal injury in mice.
Angiotensin II type-2 receptor activation in alveolar macrophages mediates protection against cigarette smoke-induced chronic obstructive pulmonary disease.
Ginseng under forest exerts stronger anti-aging effects compared to garden ginseng probably via regulating PI3K/AKT/mTOR pathway, SIRT1/NF-κB pathway and intestinal flora.
Transcriptomic Analysis Reveals Lactobacillus reuteri Alleviating Alcohol-Induced Liver Injury in Mice by Enhancing the Farnesoid X Receptor Signaling Pathway.
Recombinant Humanized IgG1 Antibody Protects against oxLDL-Induced Oxidative Stress and Apoptosis in Human Monocyte/Macrophage THP-1 Cells by Upregulation of MSRA via Sirt1-FOXO1 Axis.
METTL3 acetylation impedes cancer metastasis via fine-tuning its nuclear and cytosolic functions.
Disturbing NLRP3 acetylation and inflammasome assembly inhibits androgen receptor-promoted inflammatory responses and prostate cancer progression.
Hyperglycemia promotes myocardial dysfunction via the ERS-MAPK10 signaling pathway in db/db mice.
SIRT2 promotes the viability, invasion and metastasis of osteosarcoma cells by inhibiting the degradation of Snail.
O-GlcNAcylation of SIRT1 Protects against Cold Stress-Induced Skeletal Muscle Damage via Amelioration of Mitochondrial Homeostasis.
A High-Fat Diet Induces Muscle Mitochondrial Dysfunction and Impairs Swimming Capacity in Zebrafish: A New Model of Sarcopenic Obesity.
Aberrant methylmalonylation underlies methylmalonic acidemia and is attenuated by an engineered sirtuin.
SIRT1 prevents cigarette smoking-induced lung fibroblasts activation by regulating mitochondrial oxidative stress and lipid metabolism.
Circular RNA PVT1 inhibits tendon stem/progenitor cell senescence by sponging microRNA-199a-5p.
Polysaccharides from Platycodonis Radix ameliorated respiratory syncytial virus-induced epithelial cell apoptosis and inflammation through activation of miR-181a-mediated Hippo and SIRT1 pathways.
Polydatin Attenuates Intra-Uterine Growth Retardation-Induced Liver Injury and Mitochondrial Dysfunction in Weanling Piglets by Improving Energy Metabolism and Redox Balance.
Modification of lysine deacetylation regulates curcumol-induced necroptosis through autophagy in hepatic stellate cells.
SIRT1 alleviates IL-1β induced nucleus pulposus cells pyroptosis via mitophagy in intervertebral disc degeneration.
Estradiol initiates the immune escape of non-small cell lung cancer cells via ERβ/SIRT1/FOXO3a/PD-L1 axis.
Sirt1 protects against hippocampal atrophy and its induced cognitive impairment in middle-aged mice.
Integrated metabolism and epigenetic modifications in the macrophages of mice in responses to cold stress.
Inhibition of nuclear deacetylase Sirtuin-1 induces mitochondrial acetylation and calcium overload leading to cell death.
MG53 protein rejuvenates hUC-MSCs and facilitates their therapeutic effects in AD mice by activating Nrf2 signaling pathway.
Selenium alleviates cadmium-induced aging via mitochondrial quality control in the livers of sheep.
Phenylalanine impairs insulin signaling and inhibits glucose uptake through modification of IRβ.
Effect of Qingyangshen glycosides on social defeat mice model.
NAD(P)H: quinone oxidoreductase 1 attenuates oxidative stress and apoptosis by regulating Sirt1 in diabetic nephropathy.
Iron overload inhibits cell proliferation and promotes autophagy via PARP1/SIRT1 signaling in endometriosis and adenomyosis.
Ubiquitin-specific protease 3 attenuates interleukin-1β-mediated chondrocyte senescence by deacetylating forkhead box O-3 via sirtuin-3.
Ginsenoside CK ameliorates hepatic lipid accumulation via activating the LKB1/AMPK pathway in vitro and in vivo.
A plant-derived natural photosynthetic system for improving cell anabolism.
Small ubiquitin-related modifier (SUMO)ylation of SIRT1 mediates (-)-epicatechin inhibited- differentiation of cardiac fibroblasts into myofibroblasts.
Nicotinamide mononucleotide promotes pancreatic islet function through the SIRT1 pathway in mice after severe burns.
Resveratrol inhibits the progression of premature senescence partially by regulating v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA) and sirtuin 1 (SIRT1).
Epigallocatechin-3-gallate (EGCG) attenuates inflammatory responses and oxidative stress in lipopolysaccharide (LPS)-induced endometritis via silent information regulator transcript-1 (SIRT1)/nucleotide oligomerization domain (NOD)-like receptor pyrin domain-containing 3 (NLRP3) pathway.
Spermidine Alleviates Intrauterine Hypoxia-Induced Offspring Newborn Myocardial Mitochondrial Damage in Rats by Inhibiting Oxidative Stress and Regulating Mitochondrial Quality Control.
Quercetin protects against LPS-induced lung injury in mice via SIRT1-mediated suppression of PKM2 nuclear accumulation.
Cordycepin exhibits anti-fatigue effect via activating TIGAR/SIRT1/PGC-1α signaling pathway.
Response of the Sirtuin/PXR signaling pathway in Mugilogobius chulae exposed to environmentally relevant concentration Paracetamol.
Styrylpyrones from Phellinus linteus Mycelia Alleviate Non-Alcoholic Fatty Liver by Modulating Lipid and Glucose Metabolic Homeostasis in High-Fat and High-Fructose Diet-Fed Mice.
Deficiency of Sirtuin 1 Impedes Endometrial Decidualization in Recurrent Implantation Failure Patients.
Sustained Release of MiR-217 Inhibitor by Nanoparticles Facilitates MSC-Mediated Attenuation of Neointimal Hyperplasia After Vascular Injury.
Exploring the Oxidative Stress Mechanism of Buyang Huanwu Decoction in Intervention of Vascular Dementia Based on Systems Biology Strategy.
l-Theanine Ameliorates d-Galactose-Induced Brain Damage in Rats via Inhibiting AGE Formation and Regulating Sirtuin1 and BDNF Signaling Pathways.
Protective Effects of Huangqi Shengmai Yin on Type 1 Diabetes-Induced Cardiomyopathy by Improving Myocardial Lipid Metabolism.
Protective Effects of N(1)-Methylnicotinamide Against High-Fat Diet- and Age-Induced Hearing Loss via Moderate Overexpression of Sirtuin 1 Protein.
Ulinastatin protects against acetaminophen-induced liver injury by alleviating ferroptosis via the SIRT1/NRF2/HO-1 pathway.
Protective Effects and Mechanisms of Polyethylene Glycol Loxenatide Against Hyperglycemia and Liver Injury in db/db diabetic Mice.
β-hydroxybutyrate Alleviates Learning and Memory Impairment Through the SIRT1 Pathway in D-Galactose-Injured Mice.
Impaired Nicotinamide Adenine Dinucleotide Biosynthesis in the Kidney of Chronic Kidney Disease.
Dexmedetomidine Protects Against Septic Liver Injury by Enhancing Autophagy Through Activation of the AMPK/SIRT1 Signaling Pathway.
S100A11 Promotes Liver Steatosis via FOXO1-Mediated Autophagy and Lipogenesis.
Exercise training ameliorates early diabetic kidney injury by regulating the H(2) S/SIRT1/p53 pathway.
The effects of compound centella formula on OxInflammation and silent information regulator 1 in a high-fat diet/streptozotocin-induced diabetic kidney disease rat model.
Loss of Elp1 perturbs histone H2A.Z and the Notch signaling pathway.
miR-132-3p promotes the cisplatin-induced apoptosis and inflammatory response of renal tubular epithelial cells by targeting SIRT1 via the NF-κB pathway.
Advanced Maternal Age-associated SIRT1 Deficiency Compromises Trophoblast Epithelial-Mesenchymal Transition through an Increase in Vimentin Acetylation.
Influence of psychostimulants and opioids on epigenetic modification of class III histone deacetylase (HDAC)-sirtuins in glial cells.
Exercise Intervention Mitigates Pathological Liver Changes in NAFLD Zebrafish by Activating SIRT1/AMPK/NRF2 Signaling.
Melatonin alleviated oxidative stress induced by energy restriction on sheep Leydig cells through Sirt1/Sod2 pathway.
Hepatic COX-2 expression protects mice from an alcohol-high fat diet-induced metabolic disorder by involving protein acetylation related energy metabolism.
Danthron ameliorates obesity and MAFLD through activating the interplay between PPARα/RXRα heterodimer and adiponectin receptor 2.
The near-infrared dye IR-61 restores erectile function in a streptozotocin-induced diabetes model via mitochondrial protection.
Effect of circular RNA, mmu_circ_0000296, on neuronal apoptosis in chronic cerebral ischaemia via the miR-194-5p/Runx3/Sirt1 axis.
Exercise improves lipid droplet metabolism disorder through activation of AMPK-mediated lipophagy in NAFLD.
SIRT1 inhibitors mitigate radiation-induced GI syndrome by enhancing intestinal-stem-cell survival.
Amelioration of Juglanin against LPS-Induced Activation of NLRP3 Inflammasome in Chondrocytes Mediated by SIRT1.
Melatonin inhibits lipid accumulation to repress prostate cancer progression by mediating the epigenetic modification of CES1.
CD38 deficiency alleviates Ang II-induced vascular remodeling by inhibiting small extracellular vesicle-mediated vascular smooth muscle cell senescence in mice.
The SESAME complex regulates cell senescence through the generation of acetyl-CoA.
Theaflavin Promotes Mitochondrial Abundance and Glucose Absorption in Myotubes by Activating the CaMKK2-AMPK Signal Axis via Calcium-Ion Influx.
Selenium Deficiency-Induced Damage and Altered Expression of Mitochondrial Biogenesis Markers in the Kidneys of Mice.
Hyperglycemia-reduced NAD(+) biosynthesis impairs corneal epithelial wound healing in diabetic mice.
MAR1 suppresses inflammatory response in LPS-induced RAW 264.7 macrophages and human primary peripheral blood mononuclear cells via the SIRT1/PGC-1α/PPAR-γ pathway.
The miRNA199a/SIRT1/P300/Yy1/sST2 signaling axis regulates adverse cardiac remodeling following MI.
Abdominal Massage Alleviates Skeletal Muscle Insulin Resistance by Regulating the AMPK/SIRT1/PGC-1α Signaling Pathway.
Dimethyl fumarate ameliorates endotoxin-induced acute kidney injury against macrophage oxidative stress.
Resveratrol and its derivative pterostilbene attenuate oxidative stress-induced intestinal injury by improving mitochondrial redox homeostasis and function via SIRT1 signaling.
Long non-coding RNA MCM3AP-AS1 protects chondrocytes ATDC5 and CHON-001 from IL-1β-induced inflammation via regulating miR-138-5p/SIRT1.
Ginsenoside Rg5 Improves Insulin Resistance and Mitochondrial Biogenesis of Liver via Regulation of the Sirt1/PGC-1α Signaling Pathway in db/db Mice.
Curcumin and Resveratrol Improve Muscle Function and Structure through Attenuation of Proteolytic Markers in Experimental Cancer-Induced Cachexia.
Melatonin Ameliorates Lipopolysaccharide-Induced Microglial Inflammation via Triggering SIRT1/HMGB1 Signaling Axis.
Cigarette smoke-inactivated SIRT1 promotes autophagy-dependent senescence of alveolar epithelial type 2 cells to induce pulmonary fibrosis.
Corrigendum to article "Quantitative proteomics reveals that long non-coding RNA MALAT1 interacts with DBC1 to regulate p53 acetylation''.
Ketamine ameliorates hypoxia-induced endothelial injury in human umbilical vein endothelial cells.
Time-Restricted Feeding Reduces the Detrimental Effects of a High-Fat Diet, Possibly by Modulating the Circadian Rhythm of Hepatic Lipid Metabolism and Gut Microbiota.
Effect of Quercetin on PC12 Alzheimer's Disease Cell Model Induced by Aβ (25-35) and Its Mechanism Based on Sirtuin1/Nrf2/HO-1 Pathway.
A Newly Synthesized Rhamnoside Derivative Alleviates Alzheimer's Amyloid-β-Induced Oxidative Stress, Mitochondrial Dysfunction, and Cell Senescence through Upregulating SIRT3.
Cumulative Effect of Cardiovascular Risk Factors on Regulation of AMPK/SIRT1-PGC-1α-SIRT3 Pathway in the Human Erectile Tissue.
Septin4 Prevents PDGF-BB-induced HAVSMC Phenotypic Transformation, Proliferation and Migration by Promoting SIRT1-STAT3 Deacetylation and Dephosphorylation.
Astragalus Polysaccharides Inhibits Tumorigenesis and Lipid Metabolism Through miR-138-5p/SIRT1/SREBP1 Pathway in Prostate Cancer.
Quercetin Attenuates Atherosclerosis via Modulating Oxidized LDL-Induced Endothelial Cellular Senescence.
MicroRNA-34a Inhibition Alleviates Lung Injury in Cecal Ligation and Puncture Induced Septic Mice.
Exosomes derived from GDNF-modified human adipose mesenchymal stem cells ameliorate peritubular capillary loss in tubulointerstitial fibrosis by activating the SIRT1/eNOS signaling pathway.
SIRT1-dependent mitochondrial biogenesis supports therapeutic effects of resveratrol against neurodevelopment damage by fluoride.
miR-29a Modulates GSK3β/SIRT1-Linked Mitochondrial Proteostatic Stress to Ameliorate Mouse Non-Alcoholic Steatohepatitis.
Consumption of a Blueberry-Enriched Diet by Women for 6 Weeks Alters Determinants of Human Muscle Progenitor Cell Function.
Sodium butyrate promotes milk fat synthesis in bovine mammary epithelial cells via GPR41 and its downstream signalling pathways.
Melatonin Rescues the Ti Particle-Impaired Osteogenic Potential of Bone Marrow Mesenchymal Stem Cells via the SIRT1/SOD2 Signaling Pathway.
Revealing active components, action targets and molecular mechanism of Gandi capsule for treating diabetic nephropathy based on network pharmacology strategy.
A translational program that suppresses metabolism to shield the genome.
Anomalous AMPK-regulated angiotensin AT(1)R expression and SIRT1-mediated mitochondrial biogenesis at RVLM in hypertension programming of offspring to maternal high fructose exposure.
Melatonin enhances mitochondrial biogenesis and protects against rotenone-induced mitochondrial deficiency in early porcine embryos.
The effect of high glucose on the biological characteristics of nucleus pulposus-derived mesenchymal stem cells.
Berbamine ameliorates ethanol-induced liver injury by inhibition of hepatic inflammation in mice.
The effect of swimming exercise and diet on the hypothalamic inflammation of ApoE-/- mice based on SIRT1-NF-κB-GnRH expression.
Satellite Cells and Markers of Muscle Regeneration during Unloading and Reloading: Effects of Treatment with Resveratrol and Curcumin.
Insufficiency of melatonin in follicular fluid is a reversible cause for advanced maternal age-related aneuploidy in oocytes.
Differential structural features in soleus and gastrocnemius of carnitine-treated cancer cachectic rats.
Antrodan Alleviates High-Fat and High-Fructose Diet-Induced Fatty Liver Disease in C57BL/6 Mice Model via AMPK/Sirt1/SREBP-1c/PPARγ Pathway.
Spermidine alleviates cardiac aging by improving mitochondrial biogenesis and function.
Muscle Phenotype, Proteolysis, and Atrophy Signaling During Reloading in Mice: Effects of Curcumin on the Gastrocnemius.
Ubiquinol-10 delays postovulatory oocyte aging by improving mitochondrial renewal in pigs.
Neuroinflammation induced by secretion of acetylated HMGB1 from activated microglia in hippocampi of mice following chronic cold exposure.
Anti-insulin resistance effects of salidroside through mitochondrial quality control.
GABA-mediated activated microglia induce neuroinflammation in the hippocampus of mice following cold exposure through the NLRP3 inflammasome and NF-κB signaling pathways.
Fengbaisan suppresses endoplasmic reticulum stress by up-regulating SIRT1 expression to protect rats with chronic obstructive pulmonary diseases.
Functional Food XingJiuTang Attenuates Alcohol-Induced Liver Injury by Regulating SIRT1/Nrf-2 Signaling Pathway.
Neuroprotective effects and mechanisms of action of nicotinamide mononucleotide (NMN) in a photoreceptor degenerative model of retinal detachment.
Mitochondrial Nuclear Retrograde Regulator 1 (MNRR1) rescues the cellular phenotype of MELAS by inducing homeostatic mechanisms.
Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism.
WWP2 regulates SIRT1-STAT3 acetylation and phosphorylation involved in hypertensive angiopathy.
Atorvastatin promotes bone formation in aged apoE(-/-) mice through the Sirt1-Runx2 axis.
Schisandrin ameliorates cognitive deficits, endoplasmic reticulum stress and neuroinflammation in streptozotocin (STZ)-induced Alzheimer's disease rats.
Pum2 mediates Sirt1 mRNA decay and exacerbates hypoxia/reoxygenation-induced cardiomyocyte apoptosis.
Associations of sirtuins with clinicopathological variables and prognosis in human ovarian cancer.
Comprehensive Analysis of Expression and Prognostic Value of Sirtuins in Ovarian Cancer.
Propofol Alleviates DNA Damage Induced by Oxygen Glucose Deprivation and Reperfusion via FoxO1 Nuclear Translocation in H9c2 Cells.
Protective Effects of Dioscin Against Doxorubicin-Induced Hepatotoxicity Via Regulation of Sirt1/FOXO1/NF-κb Signal.
Feeding restriction alleviates high carbohydrate diet-induced oxidative stress and inflammation of Megalobrama amblycephala by activating the AMPK-SIRT1 pathway.
A positive feedback loop of SIRT1 and miR17HG promotes the repair of DNA double-stranded breaks.
Partially Hydrolyzed Guar Gum Attenuates d-Galactose-Induced Oxidative Stress and Restores Gut Microbiota in Rats.
Myricanol modulates skeletal muscle-adipose tissue crosstalk to alleviate high-fat diet-induced obesity and insulin resistance.
SIRT1 activation attenuates cardiac fibrosis by endothelial-to-mesenchymal transition.
Anti-ageing and antioxidant effects of sulfate oligosaccharides from green algae Ulva lactuca and Enteromorpha prolifera in SAMP8 mice.
The protective effect of lithocholic acid on the intestinal epithelial barrier is mediated by the vitamin D receptor via a SIRT1/Nrf2 and NF-κB dependent mechanism in Caco-2 cells.
Sodium/calcium overload and Sirt1/Nrf2/OH-1 pathway are critical events in mercuric chloride-induced nephrotoxicity.
The protective effect of oleanolic acid on NMDA-induced MLE-12 cells apoptosis and lung injury in mice by activating SIRT1 and reducing NF-κB acetylation.
Osteocyte TSC1 promotes sclerostin secretion to restrain osteogenesis in mice.
CERKL regulates autophagy via the NAD-dependent deacetylase SIRT1.
Neuroprotective Effects of Ginsenosides against Cerebral Ischemia.
Sirtuin-mediated deacetylation of hnRNP A1 suppresses glycolysis and growth in hepatocellular carcinoma.
Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents.
High fructose diet induces early mortality via autophagy factors accumulation in the rostral ventrolateral medulla as ameliorated by pioglitazone.
The effect of intervertebral disc degenerative change on biological characteristics of nucleus pulposus mesenchymal stem cell: an in vitro study in rats.
Abnormal expression of SIRTs in psoriasis: Decreased expression of SIRT 1-5 and increased expression of SIRT 6 and 7.
Complement C3 activation regulates the production of tRNA-derived fragments Gly-tRFs and promotes alcohol-induced liver injury and steatosis.
Ambient particulate matter attenuates Sirtuin1 and augments SREBP1-PIR axis to induce human pulmonary fibroblast inflammation: molecular mechanism of microenvironment associated with COPD.
HMGB1-mediated differential response on hippocampal neurotransmitter disorder and neuroinflammation in adolescent male and female mice following cold exposure.
Catalpol alleviates adriamycin-induced nephropathy by activating the SIRT1 signalling pathway in vivo and in vitro.
Bone marrow mesenchymal stem cells could reduce the toxic effects of hexavalent chromium on the liver by decreasing endoplasmic reticulum stress-mediated apoptosis via SIRT1/HIF-1α signaling pathway in rats.
MicroRNA-128-3p aggravates doxorubicin-induced liver injury by promoting oxidative stress via targeting Sirtuin-1.
Corneal Denervation Causes Epithelial Apoptosis Through Inhibiting NAD+ Biosynthesis.
Nicotinamide phosphoribosyl transferase regulates cell growth via the Sirt1/P53 signaling pathway and is a prognosis marker in colorectal cancer.
Effects of SIRT1 silencing on viability, invasion and metastasis of human glioma cell lines.
Resveratrol Improves the Energy Sensing and Glycolipid Metabolism of Blunt Snout Bream Megalobrama amblycephala Fed High-Carbohydrate Diets by Activating the AMPK-SIRT1-PGC-1α Network.
Modified Si-Ni-San Decoction Ameliorates Central Fatigue by Improving Mitochondrial Biogenesis in the Rat Hippocampus.
Electroacupuncture: A Feasible Sirt1 Promoter Which Modulates Metainflammation in Diet-Induced Obesity Rats.
2,3,5,4'-Tetrahydroxystilbene-2-O-β-glucoside potentiates self-renewal of human dental pulp stem cells via the AMPK/ERK/SIRT1 axis.
Layer-by-layer assembled gold nanoshells for the intracellular delivery of miR-34a.
Cardioprotection of CAPE-oNO(2) against myocardial ischemia/reperfusion induced ROS generation via regulating the SIRT1/eNOS/NF-κB pathway in vivo and in vitro.
Synergistic Effects of Salvianolic Acid B and Puerarin on Cerebral Ischemia Reperfusion Injury.
Regulation on SIRT1-PGC-1α/Nrf2 pathway together with selective inhibition of aldose reductase makes compound hr5F a potential agent for the treatment of diabetic complications.
Metformin Sensitizes Non-small Cell Lung Cancer Cells to an Epigallocatechin-3-Gallate (EGCG) Treatment by Suppressing the Nrf2/HO-1 Signaling Pathway.
Resveratrol ameliorates diet-induced dysregulation of lipid metabolism in zebrafish (Danio rerio).
Regulation of autophagy by AMP-activated protein kinase/sirtuin 1 pathway reduces spinal cord neurons damage.
Quantitative proteomics reveals that long non-coding RNA MALAT1 interacts with DBC1 to regulate p53 acetylation.
Salidroside ameliorates sepsis-induced acute lung injury and mortality via downregulating NF-κB and HMGB1 pathways through the upregulation of SIRT1.
The Effects of Resveratrol on Inflammation and Oxidative Stress in a Rat Model of Chronic Obstructive Pulmonary Disease.
TRPC5 channel modulates endothelial cells senescence.
Resveratrol attenuates ICAM-1 expression and monocyte adhesiveness to TNF-α-treated endothelial cells: evidence for an anti-inflammatory cascade mediated by the miR-221/222/AMPK/p38/NF-κB pathway.
AMPK/α-Ketoglutarate Axis Regulates Intestinal Water and Ion Homeostasis in Young Pigs.
Short- and Long-Term Hindlimb Immobilization and Reloading: Profile of Epigenetic Events in Gastrocnemius.
Hormetic effect of panaxatriol saponins confers neuroprotection in PC12 cells and zebrafish through PI3K/AKT/mTOR and AMPK/SIRT1/FOXO3 pathways.
miR-138-5p suppresses autophagy in pancreatic cancer by targeting SIRT1.
Antiaging Effect of Inula britannica on Aging Mouse Model Induced by D-Galactose.
The Polyphenol Oleuropein Aglycone Modulates the PARP1-SIRT1 Interplay: An In Vitro and In Vivo Study.
Capsaicin reactivates hMOF in gastric cancer cells and induces cell growth inhibition.
Lycium barbarum polysaccharide attenuates high-fat diet-induced hepatic steatosis by up-regulating SIRT1 expression and deacetylase activity.
Effects of physical exercise on myokines expression and brown adipose-like phenotype modulation in rats fed a high-fat diet.
Sirtuin 1 Promotes Hyperoxia-Induced Lung Epithelial Cell Death Independent of NF-E2-Related Factor 2 Activation.
Dioscin alleviates dimethylnitrosamine-induced acute liver injury through regulating apoptosis, oxidative stress and inflammation.
Total Flavonoids from Rosa laevigata Michx Fruit Ameliorates Hepatic Ischemia/Reperfusion Injury through Inhibition of Oxidative Stress and Inflammation in Rats.
Protective Effect of the Total Flavonoids from Rosa laevigata Michx Fruit on Renal Ischemia-Reperfusion Injury through Suppression of Oxidative Stress and Inflammation.
Interleukin-6-stimulated progranulin expression contributes to the malignancy of hepatocellular carcinoma cells by activating mTOR signaling.
Resveratrol Ameliorated Vascular Calcification by Regulating Sirt-1 and Nrf2.
Expression of hMOF, but not HDAC4, is responsible for the global histone H4K16 acetylation in gastric carcinoma.
RhNRG-1β Protects the Myocardium against Irradiation-Induced Damage via the ErbB2-ERK-SIRT1 Signaling Pathway.
Curcumin treatment enhances the effect of exercise on mitochondrial biogenesis in skeletal muscle by increasing cAMP levels.
Effects of Aging and Cardiovascular Disease Risk Factors on the Expression of Sirtuins in the Human Corpus Cavernosum.
Quadriceps muscle weakness and atrophy are associated with a differential epigenetic profile in advanced COPD.
Expression of hMOF in different ovarian tissues and its effects on ovarian cancer prognosis.
Natural mineral-rich water ingestion improves hepatic and fat glucocorticoid-signaling and increases sirtuin 1 in an animal model of metabolic syndrome.
Sirt1 is involved in decreased bone formation in aged apolipoprotein E-deficient mice.
Do epigenetic events take place in the vastus lateralis of patients with mild chronic obstructive pulmonary disease?
Tetramethylpyrazine ameliorates high glucose-induced endothelial dysfunction by increasing mitochondrial biogenesis.
Ubiquitin-specific peptidase USP22 negatively regulates the STAT signaling pathway by deubiquitinating SIRT1.
Effects of natural mineral-rich water consumption on the expression of sirtuin 1 and angiogenic factors in the erectile tissue of rats with fructose-induced metabolic syndrome.
The protease Omi regulates mitochondrial biogenesis through the GSK3β/PGC-1α pathway.
Long-term high-fat consumption leads to downregulation of Akt phosphorylation of eNOS at Ser1177 and upregulation of Sirtuin-1 expression in rat cavernous tissue.
Exogenous NAD(+) supplementation protects H9c2 cardiac myoblasts against hypoxia/reoxygenation injury via Sirt1-p53 pathway.
Butyrate-producing probiotics reduce nonalcoholic fatty liver disease progression in rats: new insight into the probiotics for the gut-liver axis.
MiR-138 induces renal carcinoma cell senescence by targeting EZH2 and is downregulated in human clear cell renal cell carcinoma.
Essa HA, ElMosbah DE, Fahmy HA
PloS one 2026;21(1):e0339641
PloS one 2026;21(1):e0339641
4-Methylesculetin Ameliorates Hepatic Insulin Resistance in HepG2 Cells Through AMPK/FOXO1, PI3K/AKT/GSK3β Pathways and SIRT1/NOX4 Axis.
Su X, Du Y, Yang Y, Zhao Y, Zhao H, Xie J, Shan Z, Wang M, Huang Z, Fu W, Wan A, An Y, Zhao B
Journal of diabetes research 2026;2026(1):e8023146
Journal of diabetes research 2026;2026(1):e8023146
H3K18 lactylation-mediated SPHK1-SIRT1 feedback loop accelerates pyroptosis of tubular epithelial cells in sepsis-associated acute kidney injury.
Huang Y, Zhao E, Zhao G, Zhuo W, Zhao Y, Wang H, Lv G, Hu R, Zeng Z, Han S, Hu Y, Zhao G
Theranostics 2026;16(9):4768-4786
Theranostics 2026;16(9):4768-4786
Lithospermic Acid Improves Doxorubicin-Induced Cardiomyopathy Through Sirtuin-3-Mediated Deacetylation of p53.
Zhao Y, Xu T, Ye C, Zhang K, Heng X, Huang S, Chen Y, Guo Y, Shao S, Wen Z, Shao C, Lu X, Sun N, Yang H
Phytotherapy research : PTR 2026 Mar;40(3):965-985
Phytotherapy research : PTR 2026 Mar;40(3):965-985
MED1 IDR deacetylation controls stress responsive genes through RNA Pol II recruitment.
Lin R, Mo Y, Barrows D, Mei W, Onikubo T, Sun J, Zhang Z, Apostolou E, Tavazoie SF, Roeder RG
Nature chemical biology 2026 Mar;22(3):501-513
Nature chemical biology 2026 Mar;22(3):501-513
Microglia Dld-K127 lactylation promotes Parkinson's disease via regulating the metabolism of lactate-pyruvate transformation.
Wang G, Gong G, Yang X, Qian Y, Zhao Y, Li D, Liu M, Xu Z, Zhang F
Journal of advanced research 2026 Mar 9;
Journal of advanced research 2026 Mar 9;
Fermented Black Soybean and Dehulled Adlay Improve Metabolic Syndrome via AMPK-SIRT1 Activation and Gut Microbiota Modulation.
Kuo YR, Zheng YW, Ho PY, Lo YC, Tsai PJ, Pan MH
Journal of agricultural and food chemistry 2026 Mar 4;74(8):6864-6877
Journal of agricultural and food chemistry 2026 Mar 4;74(8):6864-6877
Genetic deletion of adenosine A(2A) receptors attenuates memory deterioration and alterations of synaptic plasticity and metabolic controllers in the hippocampus and prefrontal cortex of aged mice.
Lopes CR, Madeira D, Piteira M, Valada P, Santos J, Silva HB, Gonçalves FQ, Tomé ÂR, Canas PM, Lopes JP, Ferreira SG, Agostinho P, Cunha RA
GeroScience 2026 Mar 30;
GeroScience 2026 Mar 30;
Atractylodes macrocephala Koidz. water extract alleviates exercise-induced fatigue by activating mitochondrial biogenesis via the PGC-1α/NRF1/TFAM axis.
Ying G, Yu J, Jiao L, Liang J, Wu Z, Pan B, Gao S, Chen S, Lv G
Journal of ethnopharmacology 2026 Mar 25;359:121053
Journal of ethnopharmacology 2026 Mar 25;359:121053
METTL1-deficient mesenchymal stem cells protect against metabolic-associated fatty liver disease by increasing NAMPT secretion.
Du J, Zhang Y, Wang C, Wang Y, Zhang H, Zhao D, Lin J
Stem cells translational medicine 2026 Mar 23;15(4)
Stem cells translational medicine 2026 Mar 23;15(4)
Melatonin Ameliorates decaBDE-Induced Autism-Relevant Behaviors Through Promoting SIRT1/SIRT3/FOXO3a-Dependent Mitochondrial Quality Control.
Gao L, Shen J, Gao J, Li T, Yan D, Zeng X, Meng J, Li H, Chen D, Wu J
Antioxidants (Basel, Switzerland) 2026 Mar 23;15(3)
Antioxidants (Basel, Switzerland) 2026 Mar 23;15(3)
High-Intensity Interval Training Outperforms Moderate-Intensity Exercise in Hyperlipidemic ApoE⁻/⁻ Mice: A Molecular and Histological Comparison.
Qian C, Pei Z, Yang Z, Sun M, Zhang Y, Liu H, Sun Y
Frontiers in bioscience (Landmark edition) 2026 Mar 20;31(3):47751
Frontiers in bioscience (Landmark edition) 2026 Mar 20;31(3):47751
Allosteric activation of pyruvate carboxylase by Dracoflavan B(2) enhances endothelial energy metabolism to attenuate myocardial infarction.
Hong C, Li H, Liu RY, Wang R, Sun YJ, Huang YL, Wei TT, Tu PF, Zeng KW, Li J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158145
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158145
Gastric bypass surgery improves lipid metabolism and mitochondrial function through the glutamate receptor Grin3a-mediated CaMKKβ/AMPK pathway in a rat model of type 2 diabetes.
Zhang L, Wang J, Tan B, Wang X, Luan Z
Diabetic medicine : a journal of the British Diabetic Association 2026 Jan;43(1):e70170
Diabetic medicine : a journal of the British Diabetic Association 2026 Jan;43(1):e70170
Sepsis-Induced Liver Injury Mitigated by Isoferulic Acid Through Inhibition of Hepatic Ferroptosis via the SIRT1 Signaling Pathway.
Gan J, Xu T, Zhang J, Huang C, Hua Y, Xu H, Zhang G, Hu C, Pang M, Liu B, Zhou Y
Phytotherapy research : PTR 2026 Jan;40(1):3-20
Phytotherapy research : PTR 2026 Jan;40(1):3-20
Metformin alleviates presbycusis by activating the SIRT1/PINK1/GPX4 pathway in vitro and in vivo.
Zeng C, Lin W, Gu X, Chen X, Lin Y, Chen Y, Chen Z, Lin C
Inflammopharmacology 2026 Jan;34(1):729-741
Inflammopharmacology 2026 Jan;34(1):729-741
Suppression of HIF-1α alleviates the symptoms associated with diabetic retinopathy in mice.
Wang J, Fang S, Wang J, Liu W, Meng F, Zhou X, Gao L
Experimental eye research 2026 Jan;262:110741
Experimental eye research 2026 Jan;262:110741
SIRT1 Regulates Iron Metabolism to Attenuate β-Cell Dedifferentiation by Inhibiting FoxO1 Acetylation.
Li T, Ma R, Tang W, Zheng Y, Lv S, Liu Y, Wang L, Ding Y
Biological trace element research 2026 Jan;204(1):453-465
Biological trace element research 2026 Jan;204(1):453-465
Periplocin and bufalin induce cardiotoxicity by regulating AMPK/SIRT1/PGC-1α pathway to inhibit energy metabolism and trigger autophagy.
Gao X, Zhang J, Lin Y, Tian K, Tu J, Wu Z, Lv X, Hu H, Liu X, Lin S, Zhu A
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157688
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157688
Nobiletin Ameliorates Skeletal Muscle Performance in D-Galactose-Induced Aging Mice by Boosting Aerobic Metabolism.
Wang H, Zhang Y, Zhang Y, Wang X, Li Y, Ren F, Sun Y
Food science & nutrition 2026 Jan;14(1):e71416
Food science & nutrition 2026 Jan;14(1):e71416
Renal-targeted exosomes inhibiting miR-182-5p for treatment of renal ischemia-reperfusion injury.
Li Z, Sun S, Zhao Z, Guo Y, He Q, Yang M, Zheng J, Li J, Xue W, Ding C
Bioengineering & translational medicine 2026 Jan;11(1):e70081
Bioengineering & translational medicine 2026 Jan;11(1):e70081
Sodium tanshinone IIA sulfonate alleviates neuroinflammation-induced damage to hippocampal neurons by activating SIRT1 in mice with sepsis-associated encephalopathy.
Song Y, Lin W, Yuan H, Hu H, Wu S, Lu Y, Li D, Jing L, Tu S, Zhu W
Journal of ethnopharmacology 2026 Jan 30;355(Pt B):120731
Journal of ethnopharmacology 2026 Jan 30;355(Pt B):120731
SIRT1 activation by SRT2104 enhances mitophagy and reduces senescence in auditory cells.
Cho SI, Jo ER, Jang HS
Scientific reports 2026 Jan 27;16(1):6404
Scientific reports 2026 Jan 27;16(1):6404
Shen-Shuai-II-Recipe inhibits aerobic glycolysis through SIRT1 in 5/6 ablation/infarction renal failure model.
Lan T, Zhang X, Lyu X, Wu M, Wang C, Yang L
Scientific reports 2026 Jan 11;16(1):5022
Scientific reports 2026 Jan 11;16(1):5022
Flavonoid-rich extracts of Nelumbo nucifera leaves alleviate obesity in HFD-fed mice via microbiota-dependent modulation of brown fat thermogenesis.
Wang Z, Ren X, Peng Z, Zeng M, Wang Z, Chen Q, Chen J, Dai X, Christian M, Qie X, He Z
Journal of ethnopharmacology 2026 Jan 10;354:120513
Journal of ethnopharmacology 2026 Jan 10;354:120513
Lactate-mediated Ran lactylation at lysine 123 promotes astrocytes polarization after oxygen-glucose deprivation/reoxygenation.
Wang Z, Li M, Guo S, Deng C, Wang B, Gao F, Lv J, Sun L
International immunopharmacology 2026 Jan 1;168(Pt 2):115861
International immunopharmacology 2026 Jan 1;168(Pt 2):115861
Genistein Ameliorates the Ischemic State of Random Skin Flap by Regulating Macrophage Polarization Through AMPK/SIRT1 Signaling Pathway.
Fu Y, Ye C, Zhu Y, Chen T, Li Z, Chen Y
Phytotherapy research : PTR 2026 Feb;40(2):420-435
Phytotherapy research : PTR 2026 Feb;40(2):420-435
FGF2 Enhances MSCs Secretome Therapy for Skin Photoaging by Delaying Senescence via iNAMPT/AMPK Signaling and Facilitating eNAMPT-Mediated Regenerative Crosstalk.
Zhang Y, Lu M, Ouyang J, Liang L, Li F, Pei Z, Chen L, Ye M, Tan J, Xiang L, Kong L, Huang L, Fu L, Wang W, Qin L, Zhang Z, Du J
Stem cell reviews and reports 2026 Feb;22(2):941-962
Stem cell reviews and reports 2026 Feb;22(2):941-962
High-fat diet mediates the formation of nonalcoholic fatty liver by modulating the AhR/miR-132/SIRT1 axis.
Tao Q, Xie J, Zhou Y, Wu Y, Xia H, Wang J, Zhang C, Wei C, Jin Y
The Journal of nutritional biochemistry 2026 Feb;148:110174
The Journal of nutritional biochemistry 2026 Feb;148:110174
Cardiac PTN-SIRT1 axis alleviates oxidative stress and promotes mitochondrial energy reprogramming to mitigate doxorubicin-induced cardiotoxicity through AMPK/PGC1α signaling.
Sun Y, Wei T, Xu H, Li H, Zhou C, Liu X, Li Y, Huang S, Zhang Q, Duan X
Acta biochimica et biophysica Sinica 2026 Feb 5;58(2):421-436
Acta biochimica et biophysica Sinica 2026 Feb 5;58(2):421-436
Ginsenoside Rb2 improves diminished ovarian reserve through regulation of gonadal hormones and apoptosis via SIRT1.
Zhu C, Yi M, Cao H, Li H, Tang H, Xu L, Li L
Journal of ovarian research 2026 Feb 26;19(1)
Journal of ovarian research 2026 Feb 26;19(1)
The SIRT1-Mediated p53 Deacetylation Pathway Modulates Apoptosis and Promotes Viral Replication in MVC-Infected Cells.
Yan Y, Ren X, Xiao Y, Li F, Guo J, Ji K, Hei Z, Zhang Z, Sun Y
Pathogens (Basel, Switzerland) 2026 Feb 25;15(3)
Pathogens (Basel, Switzerland) 2026 Feb 25;15(3)
Preparation of Artemisia argyi-Derived Extracellular Nanovesicles and Their Protective Effects Against Oxidative Stress-Induced Senescence in Endometrial Stromal Cells.
Zheng X, Huang R, Liu Z, Liu T, Lin H, Yin L, Wu Q, Zhao M
Bioengineering (Basel, Switzerland) 2026 Feb 24;13(3)
Bioengineering (Basel, Switzerland) 2026 Feb 24;13(3)
ANGPT2/Tie2 Enhances H3K18la-Mediated Macrophage M2 Polarization to Promote Endothelial Cell Proliferation in the Chronically Ischaemic Brain.
Tai C, Ling C, Yang Y, Mo N, Yao C, Lv S, Zhang B, Wang H, Chen C
CNS neuroscience & therapeutics 2026 Apr;32(4):e70879
CNS neuroscience & therapeutics 2026 Apr;32(4):e70879
Disruption of the SIRT1/PI3K/AKT Signaling Axis Mediates Fluoride-Induced Cardiotoxicity: Evidence from in Vitro and Zebrafish Models.
Guo L, Yang B, Chen F, Yuan X, Cheng J, Chen X, Zhou Y, Yang X, Li Y, Liu Y, Tang D, Wang F
Biological trace element research 2026 Apr;204(4):2411-2426
Biological trace element research 2026 Apr;204(4):2411-2426
Delactylation of viral proteins by SIRT1 suppresses influenza A virus replication.
Chen D, Zhao G, Zhou J, Sun P, He S, Lv C, Chen Y, Zhu S, Gao M, Guo G
mBio 2026 Apr 8;17(4):e0248925
mBio 2026 Apr 8;17(4):e0248925
Pretreatment with a ketogenic diet inhibits mitochondrial damage in rat models of spinal cord injury via the PGC-1α/Sirt1/Nrf1 pathway.
Wang X, Lan W, Liao Y, Lu H
Iranian journal of basic medical sciences 2025;28(11):1516-1522
Iranian journal of basic medical sciences 2025;28(11):1516-1522
N (1)-methylnicotinamide promotes age-related cochlear damage via the overexpression of SIRT1.
Miwa T, Tarui A, Kouga T, Asai Y, Ogita H, Fujikawa T, Hakuba N
Frontiers in cellular neuroscience 2025;19:1542164
Frontiers in cellular neuroscience 2025;19:1542164
4'-Methoxyresveratrol Improves Hepatic Insulin Resistance Induced by a High-Fat-Diet via Anti-Oxidative-Stress Activity.
Zhang Z, Zhang X, Yang L, Nie Q, Song G
Diabetes, metabolic syndrome and obesity : targets and therapy 2025;18:2739-2752
Diabetes, metabolic syndrome and obesity : targets and therapy 2025;18:2739-2752
Integrated network pharmacology and experimental verification to reveal the mechanisms of curcumin in the treatment of colorectal cancer.
Yuan Z, Hu J, Cai C, Liu F, Chen H, Zeng B
Frontiers in pharmacology 2025;16:1703562
Frontiers in pharmacology 2025;16:1703562
Cardiac protection of wogonin in mice with pulmonary fibrosis by regulating Sirt1/ γ-H2AX pathway.
Wang L, Lin F, Miao R, Zhao T, Liu Y, Yang L, Zhang M
Frontiers in pharmacology 2025;16:1551141
Frontiers in pharmacology 2025;16:1551141
Alisol A ameliorates vascular cognitive impairment via AMPK/NAMPT/SIRT1-mediated regulation of cholesterol and autophagy.
Xu P, Zhou W, Wang S, Wang L, Bai Y, Xing S, Xue W, Li M, Shi J, Wu H
Theranostics 2025;15(18):9415-9446
Theranostics 2025;15(18):9415-9446
The Effects of M2 Macrophages-Derived Exosomes on Urethral Fibrosis and Stricture in Scar Formation.
Ren X, Wang Z, Wang J, Li X, Wei H, Liu C, Liu S, Zhu Y, Feng C, Yin Y, Tian Y, Wu M, Zeng X
ImmunoTargets and therapy 2025;14:151-173
ImmunoTargets and therapy 2025;14:151-173
Claudin-1 impairs blood-brain barrier by downregulating endothelial junctional proteins in traumatic brain injury.
Gowrikumar S, Tarudji A, McDonald BZ, Balusa SS, Kievit FM, Dhawan P
Tissue barriers 2025;13(4):2470482
Tissue barriers 2025;13(4):2470482
Ozone water enema activates SIRT1-Nrf2/HO-1 pathway to ameliorate gut dysbiosis in mice receiving COVID-19 patient-derived faecal microbiota.
Su Z, Lin J, Zeng X, Li X, Hou Q, Wang Q, Liu C, Qin J, Li Y, Zhang J, Wang X, Qian S, Liao L
Journal of medical microbiology 2025 Sep;74(9)
Journal of medical microbiology 2025 Sep;74(9)
Agomelatine alleviates palmitic acid-induced mouse oocyte meiosis defects by restoring mitochondrial function.
Zhao R, Tang Y, Zhang Y, Liu J, Zhong C, Ji B, Song W, Zhang C, Su J
International journal of obesity (2005) 2025 Sep;49(9):1781-1791
International journal of obesity (2005) 2025 Sep;49(9):1781-1791
The Role of SIRT1-BDNF Signaling Pathway in Fluoride-Induced Toxicity for Glial BV-2 Cells.
Yang B, Wang F, Yang X, Yuan X, Yang Y, Chen X, Tian T, Chen F, Tang D, He Z, Liu Y, Li Y
Biological trace element research 2025 Sep;203(9):4789-4806
Biological trace element research 2025 Sep;203(9):4789-4806
Flavonoids in Rosa roxburghii Tratt Fermentation Broth Ameliorate Obesity via DNMT3a/SIRT1-Mediated Epigenetic Modulation.
Liu M, Li H, Zhang J, Zhong Y, Huang C, Zhu L, Hu Z, Xu Y, Zhao S, Pan W
Food science & nutrition 2025 Sep;13(9):e70892
Food science & nutrition 2025 Sep;13(9):e70892
Salidroside protects bovine hepatocytes against fatty acid-induced lipid accumulation and inflammation by activating AMPK/SIRT1 pathway.
Li J, Zhao C, Zu K, Fan Z, Qi D, Kong F, Liu M, Gao J, Li E, Gao W, Du X, Song Y, Liu G, Li X, Feng H, Lei L
Journal of dairy science 2025 Sep;108(9):10136-10150
Journal of dairy science 2025 Sep;108(9):10136-10150
Effects of Tributyrin on Antioxidant Capacity, Immune Function, and Liver Macrophage Polarization in Weaned Piglets Under LPS Challenge.
Yuan M, Ning S, Yu D, Long F, Li W, Qi J, Liang Y, Hong C, Tang Y, Liu C, Wang G, Wu B, Zhong X
Animals : an open access journal from MDPI 2025 Sep 29;15(19)
Animals : an open access journal from MDPI 2025 Sep 29;15(19)
Gut microbiota modified by Mulberry leaf water extract improves T2DM through browning of WAT/BAT activation mediated by SCFAs-AMPK/SIRT1/PGC-1α signaling pathway.
Du Y, He C, An Y, Zhao Y, Zhang H, Shan Z, Yang Y, Wang M, Xie J, Huang Y, Fu W, Yuan Y, Zhao B
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120408
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120408
Self-assembled cyanidin-3-O-glucoside nanoparticles alleviate inflammation and ferroptosis induced by PRRSV infection.
Chen X, Pang Y, Amona FM, Liu Z, Wang F, Liang Y, Yang J, Zhang W, Fang X, Chen X
Journal of virology 2025 Sep 23;99(9):e0095425
Journal of virology 2025 Sep 23;99(9):e0095425
Melatonin attenuates ischemia-reperfusion-induced acute kidney injury by regulating abnormal autophagy and pyroptosis through SIRT1-mediated p53 deacetylation.
Sun C, Liu J, Li H, Yan Y
International immunopharmacology 2025 Sep 23;162:115092
International immunopharmacology 2025 Sep 23;162:115092
Celastrol modulates IRS1 expression to alleviate ovarian aging and to enhance follicular development.
Jiang Y, Shi Y, Lv M, Wang T, Wang P, Yuan X, Gao F, Ma B
Cell biology and toxicology 2025 Sep 2;41(1):129
Cell biology and toxicology 2025 Sep 2;41(1):129
The Role of Sirt1 in Regulating Inflammatory Cytokines and Oxidative Stress in the Transition Mechanism from Depressive Disorder to Alzheimer's Disease.
Zou J, Liu L, Chai F, Shan Q, Wang Y
Molecular neurobiology 2025 Oct;62(10):13136-13152
Molecular neurobiology 2025 Oct;62(10):13136-13152
Combination of imeglimin and resistance exercise improves mitochondrial function and glucose metabolism in skeletal muscles.
Ishiguro H, Minato K, Iwaasa K, Wu S, Antao G, Tsuchida T, Suwabe T, Katagiri T, Suzuki H, Masuko M, Watanabe KI, Ushiki T, Sone H
Journal of diabetes and its complications 2025 Oct;39(10):109145
Journal of diabetes and its complications 2025 Oct;39(10):109145
SIRT1 Expression in Human Gastrointestinal Tumors and Its Clinical Significance.
Liu W, Li X, Deng W
Cancer medicine 2025 Oct;14(19):e71217
Cancer medicine 2025 Oct;14(19):e71217
LncRNA-like MMP14 RNA facilitates colorectal cancer metastasis by suppressing H3K27cr at the STARD13 promoter region.
Li M, Gao Y, Sun X, Zheng W, Zhang M, Wang C, Chu W, Yang X, Wang L, Zheng M, Xue W, Dong F, Pei D, Liao M
Cellular & molecular biology letters 2025 Oct 6;30(1):115
Cellular & molecular biology letters 2025 Oct 6;30(1):115
Luteoloside alleviates bleomycin-induced pulmonary fibrosis in mice via SIRT1-mediated protective effect against alveolar epithelial cell senescence.
Deng L, Sun B, Xia J, Zhuo W, Jiang M, Yin S, Yang F
Scientific reports 2025 Oct 29;15(1):37837
Scientific reports 2025 Oct 29;15(1):37837
Trace element-dictated exosome modules and self-adaptive dual-network hydrogel orchestrate diabetic foot regeneration through complement-mitochondria-autophagy circuitry.
Wang SQ, Jin MJ, Guo ZK, Shen DR, Jin LN, Cheng F, Zhao YR, Liu T, Li YC, Wang NY, Chen LQ, Huang W, Quan XQ, Gao ZG
Military Medical Research 2025 Oct 28;12(1):71
Military Medical Research 2025 Oct 28;12(1):71
Yunnan Baiyao regulates Th17/Treg cell homeostasis to inhibit periodontitis through the miR-155-5p/ATG5 pathway.
Zhao R, Chen R, An Y, Liu W, Zheng M, Ma S, Li Y, Ren X, He H
International immunopharmacology 2025 Oct 10;163:115253
International immunopharmacology 2025 Oct 10;163:115253
PACAP inhibits high fat-induced NLRP3 inflammasome-mediated pyroptosis in vascular endothelial cells by regulating the SIRT1/ROS pathway.
Dong J, Ma T, Qu Y, Ye R, Feng J, Bai G, Hong A, Ma Y
Molecular and cellular endocrinology 2025 Oct 1;608:112633
Molecular and cellular endocrinology 2025 Oct 1;608:112633
Disruption of ovarian function and induction of apoptosis in female mice by Brefeldin A: Mechanistic insights into reproductive toxicity.
Jiang Y, Lv M, Fan H, Shi Y, Wang T, Wang P, Yuan X, Gao F, Ma B
Animal models and experimental medicine 2025 Nov;8(11):2053-2068
Animal models and experimental medicine 2025 Nov;8(11):2053-2068
Deacetylase SIRT1 modulates antiviral innate immunity and autoimmune diseases.
Yu SS, Yu H, Geng S, Tang RC, Zhang A, Zhang Y, Sun XY, Zhang J
International journal of biological macromolecules 2025 Nov;329(Pt 2):147873
International journal of biological macromolecules 2025 Nov;329(Pt 2):147873
Inhibition of SIRT1/PGC-1α Axis Exacerbates Fluorine and Aluminium Induced Neurotoxicity via Drp1-dependent Aggravated Mitochondrial Fission.
Yang L, Qian X, Jiang H, Xie C
Molecular neurobiology 2025 Nov 26;63(1):177
Molecular neurobiology 2025 Nov 26;63(1):177
Multi-Target Botanical Complex Attenuates Cellular Senescence via Bidirectional P21/P53/SIRT1 Regulation: Dual Model Validation.
Wu J, Dongzhu N, Zhao C, Liang J, Wang N, Suonan D, Sun S
International journal of molecular sciences 2025 Nov 25;26(23)
International journal of molecular sciences 2025 Nov 25;26(23)
Flavonoids from Rosa roxburghii Tratt fermentation broth inhibit adipogenesis via the SIRT1 pathway: insights from metabolomics and network pharmacology.
Liu M, Ruan Y, Huang C, Wang S, Zhong Y, Zhang Y, Xu Y, Pan W
Food & function 2025 Nov 24;16(23):9033-9047
Food & function 2025 Nov 24;16(23):9033-9047
Metformin mitigates cisplatin-induced premature ovarian insufficiency via Sirt1/Nrf2 activation.
Zheng Y, Fu Z, Yang S, Ma Q, Liu X, Wang Y, Geng T, Hao J, Li X
Medicine 2025 Nov 21;104(47):e46122
Medicine 2025 Nov 21;104(47):e46122
Hyperosmolarity-Induced Oxidative Stress Leads to Senescence in Human Corneal Epithelial Cells (HCEPC) via DNA Damage, Metabolic Disturbance and Mitophagy Decline.
Zhang Y, Fan T
Antioxidants (Basel, Switzerland) 2025 Nov 19;14(11)
Antioxidants (Basel, Switzerland) 2025 Nov 19;14(11)
SIRT1 Alleviates Oxidative Stress-Induced Mitochondrial Dysfunction and Mitochondria-Associated Membrane Dysregulation in Stress Urinary Incontinence.
Chen L, Tang J, Zuo X, Li B, Liu C, Hong S, Min J, Hu M, Li S, Zhou M, Chen M, He Y, Xiao Y, Huang X, Hong L
Cell proliferation 2025 May;58(5):e70009
Cell proliferation 2025 May;58(5):e70009
Lycium ruthenicum Murray Anthocyanins Alleviate Aging Through SIRT1/P53 Signaling Pathway.
Liang J, Ga Z, Wu J, Wang Y, Dongzhu N, Qieyang R, Li P, Huaqian S
International journal of molecular sciences 2025 May 9;26(10)
International journal of molecular sciences 2025 May 9;26(10)
Human umbilical cord mesenchymal stem cell-derived exosomes repair IBD by activating the SIRT1-FXR pathway in macrophages.
Zhou M, Pei B, Cai P, Yi C, Akanyibah FA, Lyu C, Mao F
Stem cell research & therapy 2025 May 9;16(1):233
Stem cell research & therapy 2025 May 9;16(1):233
Dual-responsive nanoparticles targeting ACE-II senescence for therapeutic mitigation of acute lung injury.
Gao L, Zheng F, Fu Z, Wang W
Journal of nanobiotechnology 2025 May 8;23(1):339
Journal of nanobiotechnology 2025 May 8;23(1):339
Hepatic sphingomyelin phosphodiesterase 3 promotes steatohepatitis by disrupting membrane sphingolipid metabolism.
Jiang J, Gao Y, Wang J, Huang Y, Yang R, Zhang Y, Ma Y, Wen Y, Luo G, Zhang S, Cao Y, Yu M, Wang Q, Hu S, Wang K, Guo X, Gonzalez FJ, Liu Y, Liu H, Xie Q, Xie C
Cell metabolism 2025 May 6;37(5):1119-1136.e13
Cell metabolism 2025 May 6;37(5):1119-1136.e13
Insights into the potential role of BMSCs-exo delivered USP14 on SIRT1 deubiquitination in Staphylococcus aureus-induced model of osteomyelitis.
Yu J, Yang M, Jin Y, Yang K, Yang H
Journal of orthopaedic surgery and research 2025 May 29;20(1):539
Journal of orthopaedic surgery and research 2025 May 29;20(1):539
NUDT21 lactylation reprograms alternative polyadenylation to promote cuproptosis resistance.
Lin J, Yin Y, Cao J, Zhang Y, Chen J, Chen R, Zou B, Huang C, Lv Y, Xu S, Yang H, Lin P, Xie D
Cell discovery 2025 May 28;11(1):52
Cell discovery 2025 May 28;11(1):52
Xiasangju alleviates hepatic insulin resistance in db/db mice via AMPK pathway: Mechanisms and active components study.
An Y, Zhao H, He C, Shi L, Su X, Zhang H, Huang Y, Shan Z, Wang M, Du Y, Xie J, Zhao Y, Yang Y, Huang Z, Wan A, Zhao Y, Zhao B
International immunopharmacology 2025 May 27;156:114675
International immunopharmacology 2025 May 27;156:114675
Inhibition of CDK5 signaling mediated inflammation in macrophages promotes cutaneous wound healing.
Wang J, Ji L, Gao Y, Sun J, Zhou X, Ding Y, Zhou Z, Guo X, Liu C, Wang Y, Zhang Q, Lv Z, Ma D
Scientific reports 2025 May 27;15(1):18509
Scientific reports 2025 May 27;15(1):18509
Bufei Yishen formula alleviates airway epithelial cell senescence in COPD by activating AMPK-Sirt1-FoxO3a pathway and promoting autophagy.
Cheng M, Yang M, Tian Y, Liu X, Li J, Zhao P
Scientific reports 2025 May 13;15(1):16584
Scientific reports 2025 May 13;15(1):16584
Delta Opioid Peptide [d-Ala2, d-Leu5]-Enkephalin Improves Physical and Cognitive Function and Increases Lifespan in Aged Female Mice.
Huo L, Zhang H, Tang C, Cui G, Xue T, Guo H, Yao F, Zhang W, Feng W
Molecular neurobiology 2025 Mar;62(3):3568-3582
Molecular neurobiology 2025 Mar;62(3):3568-3582
Exercise-induced Activation of SIRT1/BDNF/mTORC1 Signaling Pathway: A Novel Mechanism to Reduce Neuroinflammation and Improve Post-stroke Depression.
Tang J, Lu L, Yuan J, Feng L
Actas espanolas de psiquiatria 2025 Mar;53(2):366-378
Actas espanolas de psiquiatria 2025 Mar;53(2):366-378
The potential role of the SIRT1-Nrf2 signaling pathway in alleviating hidden hearing loss via antioxidant stress.
Zheng Z, Zhang P, Fu Y, Jiang Y, Zhu J, Wang F, Li S, Zhang Z, Chang T, Li T, Zhang M, Ruan B, Wang X
Cell biology international 2025 Mar;49(3):262-276
Cell biology international 2025 Mar;49(3):262-276
Panax ginseng exerts cardioprotective effect post myocardial infarction by attenuating myocardial fibrosis and inflammation through SIRT1 signaling pathways.
Xu H, Pang M, Hu C, Xu T, Chen G, Zhang G, Han X, Hua Y, Wu Y, Zhang J, Bi Y, Liu B, Zhou Y
Journal of ginseng research 2025 Mar;49(2):197-207
Journal of ginseng research 2025 Mar;49(2):197-207
Anti-fibrosis effect and its mechanism of atractylenolide III on post-traumatic extending knee joint contracture in rats.
Zhang BB, Xu L, Zhang QB, Wang Y, Chen C, Zhang JN, Rao XL, Zhu BJ, Li XM, Zhu DT, Kan XL, Mao J, Zhang R, Zhou Y
Experimental gerontology 2025 Mar;201:112708
Experimental gerontology 2025 Mar;201:112708
Sirtuin-2 Is Involved in the Regulation of Claudin-4 Expression and Paracellular Barrier Function in Keratinocytes.
Matsuda S, Miwa M, Tanabe M, Kobayashi M, Shu S, Yoshino Y, Tada N, Itoh A, Ikari A
Journal of cellular biochemistry 2025 Mar;126(3):e70027
Journal of cellular biochemistry 2025 Mar;126(3):e70027
miR-138-5p inhibits healing of femoral fracture osteogenesis in rats by modulating osteoblast differentiation via SIRT1/FOXO1 axis.
Dai G, Jiang W, Feng B, Zhang L
Journal of orthopaedic surgery and research 2025 Mar 14;20(1):280
Journal of orthopaedic surgery and research 2025 Mar 14;20(1):280
Apoptotic vesicles derived from bone marrow mesenchymal stem cells increase angiogenesis in a hind limb ischemia model via the NAMPT/SIRT1/FOXO1 axis.
Chen J, Shen Z, Chen B, Liu S, Mei Y, Li K, Peng Z, Feng C, Wang W, Lu S
Stem cell research & therapy 2025 Mar 1;16(1):105
Stem cell research & therapy 2025 Mar 1;16(1):105
5-Demethyl-Polymethoxyflavones Mitigate Obesity by Reducing Adipose Tissue Inflammation, Promoting Browning, and Modulating Gut Microbiota in High-Fat Diet-Fed Mice.
Lin WS, Lin YL, Koh YC, Ho PY, Lin YC, Ho CT, Pan MH
Molecular nutrition & food research 2025 Jun;69(12):e70069
Molecular nutrition & food research 2025 Jun;69(12):e70069
Inhibition of SIRT1/HSF1 pathway contributes to doxorubicin-induced nephrotoxicity in ovarian tumor-bearing mice.
Chen M, Zhao Y, Hu S, Yuan JB, Xie KJ, Cai SN, Zhu XY, Du JK, Xu PB
Apoptosis : an international journal on programmed cell death 2025 Jun;30(5-6):1572-1588
Apoptosis : an international journal on programmed cell death 2025 Jun;30(5-6):1572-1588
Ginsenoside Rk1 Ameliorates Non-Alcoholic Fatty Liver Disease by Targeting CD36 to Modulate the AMPK Signaling Pathway.
Wu Y, Duan Z, Qu L, Liu Y, Ma X, Fan D
Food research international (Ottawa, Ont.) 2025 Jun;211:116426
Food research international (Ottawa, Ont.) 2025 Jun;211:116426
Cardioprotective effects of the jiming formula on myocardial metabolism in Mice with myocardial infarction via the AMPK/SIRT1/PGC-1α pathway.
Fan X, Wei X, Wang W, Chai W, Xiao J, Han J, Li F, Guo S
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156727
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156727
Pelargonidin-3-O-galactoside Alleviates Acute Lung Injury Induced by Klebsiella pneumoniae by Targeting CD38-Mediated Pyroptosis.
Jiang F, Jiang J, Sun Y, Meng L, Chen J, Liang L, Wang X, Zhang H, Meng M, Yuan B, He S, Li R
Journal of agricultural and food chemistry 2025 Jun 4;73(22):13415-13426
Journal of agricultural and food chemistry 2025 Jun 4;73(22):13415-13426
Initiating Empagliflozin and Sacubitril/Valsartan Early After Acute Myocardial Infarction: Mechanistic Study.
Martínez-Falguera D, Aranyó J, Ferrer-Curriu G, Teis A, Revuelta-Lopez E, Diaz-Güemes I, Monguió-Tortajada M, Fadeuilhe E, Rodríguez-Leor O, Poblador F, Montejo B, Roura S, Villuendas R, Sarrias A, Bazan V, Jorge E, Delgado V, Jimenez-Trinidad FR, Rigol M, Martinez-Micaelo N, Amigó N, Bayes-Genis A, Bisbal F, Gálvez-Montón C
Journal of the American Heart Association 2025 Jun 3;14(11):e040214
Journal of the American Heart Association 2025 Jun 3;14(11):e040214
Time Does Matter: The Cellular Response to Resveratrol Varies Depending on the Exposure Duration.
Gramatyka M
International journal of molecular sciences 2025 Jun 10;26(12)
International journal of molecular sciences 2025 Jun 10;26(12)
Sevoflurane: A dual modulator of miR‑211‑5p and mitochondrial apoptosis in glioma therapy.
Wang H, Cheng G, Zhang S, Qu H, Zhao X, Yang A, Sun X, Pan H
Molecular medicine reports 2025 Jul;32(1)
Molecular medicine reports 2025 Jul;32(1)
Alpha-lipoamide prevents acute kidney injury in mouse by inhibiting renal tubular epithelial cell pyroptosis.
Tan WL, Yu X, Jia J, Chen RY, Xu XX, Liang LQ, Ruan YY, Wang FF, Chen YT, Peng YL, Peng J, Shi M, Tang L, Guo B, Wang YY
Biochemical pharmacology 2025 Jul;237:116942
Biochemical pharmacology 2025 Jul;237:116942
Scutellarein ameliorates pulmonary arterial hypertension via sirtuin 1 mediated deacetylation of nicotinamide nucleotide transhydrogenase.
Tang H, Ning K, Wu B, Wang X, He J, Li P, Pan L, Zhang J, He Y, Bian S, Ma X, Zhang J, Liu C, Qin Z, Hu H
Biochemical pharmacology 2025 Jul;237:116932
Biochemical pharmacology 2025 Jul;237:116932
Systematic pharmacology and experimental validation revealed the mechanism of Bupleurum chinense DC -mediated autophagy in alleviating osteoarthritis.
Wang Y, Wang C, Zhu Y, Chen K, Yu Y, Li R, Huang S, Tao T, Jiang Y
Journal of ethnopharmacology 2025 Jul 24;351:120042
Journal of ethnopharmacology 2025 Jul 24;351:120042
Buzhong Yiqi decoction improves inflammation and oxidative damage in autoimmune thyroiditis by inhibiting apoptosis via the SIRT1-Mediated Nrf2/NF-κB axis.
Zhao Z, Li J, Song N, Gao H, Liu D, Jin Z, Chen Y, Guo X, Liu Z, Yang X
Journal of ethnopharmacology 2025 Jul 24;351:119967
Journal of ethnopharmacology 2025 Jul 24;351:119967
Trigonelline attenuated sepsis-induced acute kidney injury by activating NAD+/SIRT1 Pathway.
Lv W, Cao D, Yang F
Physiological research 2025 Jul 23;74(3):439-447
Physiological research 2025 Jul 23;74(3):439-447
Erythropoietin (EPO) Alleviates Chronic Stress-Induced Depression by Modulating SIRT1-Mediated Mitochondrial Function.
Luo Y, Ali T, Hu Y, Gong Q, Zheng C, Li L, Li S, Hao L
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2025 Jul 21;20(1):73
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2025 Jul 21;20(1):73
Exogenous H(2)S reduces oxidative stress induced by lipid mixture in HepG2 cells through USP22/SIRT1 axis.
Cui X, Li C, He S, Li Y
Scientific reports 2025 Jul 2;15(1):23129
Scientific reports 2025 Jul 2;15(1):23129
Nicotinamide riboside promoted cardiac energetics and alleviated doxorubicin-induced cardiotoxicity via SIRT1/ERRα signal in human pluripotent stem cells-derived cardiomyocytes.
Wang R, Zhang H, Yi Q, Wang YP, Xu H, Tan B, Zhu J
Life sciences 2025 Jul 15;373:123685
Life sciences 2025 Jul 15;373:123685
USP7 promotes PINK1/Parkin-dependent mitophagy to ameliorate cerebral ischemia-reperfusion injury by deubiquitinating and stabilizing SIRT1.
Hou D, Hu Y, Yun T, Yu D, Yang G
Brain research 2025 Jul 1;1858:149638
Brain research 2025 Jul 1;1858:149638
Human HDAC6 senses valine abundancy to regulate DNA damage.
Jin J, Meng T, Yu Y, Wu S, Jiao CC, Song S, Li YX, Zhang Y, Zhao YY, Li X, Wang Z, Liu YF, Huang R, Qin J, Chen Y, Cao H, Tan X, Ge X, Jiang C, Xue J, Yuan J, Wu D, Wu W, Jiang CZ, Wang P
Nature 2025 Jan;637(8044):215-223
Nature 2025 Jan;637(8044):215-223
Melatonin protects porcine oocytes from gossypol-induced meiosis defects via regulation of SIRT1-mediated mitophagy.
Su X, He Y, Li H, Yu T, Sun Q, Chen M, Zhang B, Wang W, Ju S, Li Q
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Jan;195:115122
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Jan;195:115122
LncRNA HOXB3OS improves high glucose-mediated podocyte damage and progression of diabetic kidney disease through enhancing SIRT1 mRNA stability.
Wang Y, Pang Z, He W, Ren P, He Q, Jin J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2025 Jan;182:117770
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2025 Jan;182:117770
Delphinidin or α-amyrin attenuated liver steatosis and metabolic disarrangement in rats fed a high-fat diet.
Ali BM, Elbaz EM, Al-Mokaddem AK, El-Emam SZ, Awny MM
BioFactors (Oxford, England) 2025 Jan-Feb;51(1):e2133
BioFactors (Oxford, England) 2025 Jan-Feb;51(1):e2133
MiR-128-3p promotes hyperproliferation of keratinocytes and psoriasis-like inflammation by targeting SIRT1/HIF-1α.
You J, Wang Z, Jia X
Archives of dermatological research 2025 Jan 4;317(1):165
Archives of dermatological research 2025 Jan 4;317(1):165
Fatty Acid Esterification of Octacosanol Attenuates Triglyceride and Cholesterol Synthesis in Mice.
Kamchonemenukool S, Koh YC, Ho PY, Pan MH, Weerawatanakorn M
Journal of agricultural and food chemistry 2025 Jan 29;73(4):2430-2442
Journal of agricultural and food chemistry 2025 Jan 29;73(4):2430-2442
Sirtuin-1 Regulates Mitochondrial Calcium Uptake Through Mitochondrial Calcium Uptake 1 (MICU1).
Zhang X, Liu S, Su Y, Zhang L, Guo T, Wang X
Life (Basel, Switzerland) 2025 Jan 25;15(2)
Life (Basel, Switzerland) 2025 Jan 25;15(2)
Mesoporous Prussian blue nanoparticle neuroconduit for the biological therapy targeting oxidative stress reduction, inflammation inhibition, and nerve regeneration.
Zhu J, Zhang Y, Sun Y, Yu F, Lu Y, Hu Q, Guo J, Zhang H, Chen T, Lian F, Wang J, Li X, Xiao J
Journal of nanobiotechnology 2025 Jan 2;23(1):1
Journal of nanobiotechnology 2025 Jan 2;23(1):1
Therapeutic Effects of GDF6-Overexpressing Mesenchymal Stem Cells through Upregulation of the GDF15/SIRT1 Axis in Age-Related Hearing Loss.
Liu J, Peng H, Liu Y, Li C, Xie W
Frontiers in bioscience (Landmark edition) 2025 Jan 15;30(1):26179
Frontiers in bioscience (Landmark edition) 2025 Jan 15;30(1):26179
Puerarin reduces diabetic nephropathy-induced podocyte pyroptosis by modulating the SIRT1/NLRP3/caspase-1 pathway.
Wang L, Xie X, Chen Q, Chen Y, Xu X, Liang T
Molecular and cellular endocrinology 2025 Jan 1;595:112409
Molecular and cellular endocrinology 2025 Jan 1;595:112409
Inhalation exposure to airborne PM(2.5) attenuates hepatic metabolic pathways through S-nitrosylation of the primary ER stress sensor.
Yang Z, Chen Q, Wang J, Qiu Y, Thepsuwan P, Yi Z, Heng HH, Sun Q, Chen X, Li L, He P, Zhang R, Zhang K
American journal of physiology. Cell physiology 2025 Jan 1;328(1):C212-C226
American journal of physiology. Cell physiology 2025 Jan 1;328(1):C212-C226
Melatonin alleviates oxidative stress and inflammation of Leydig cells of Min pig through SIRT1 pathway.
Chen Y, Tang Y, Liu B, Wang J, Wang H, Li B, Liu S, Adeniran SO, Zheng P
Theriogenology 2025 Feb;233:112-122
Theriogenology 2025 Feb;233:112-122
Aptamer-Conjugated Exosomes Ameliorate Diabetes-Induced Muscle Atrophy by Enhancing SIRT1/FoxO1/3a-Mediated Mitochondrial Function.
Song J, Yang M, Xia L, Wang L, Wang K, Xiang Y, Cheng J, Chen J, Liu J, Zhao R, Liu F, Sun Z, Hou X, Zang N, Chen L
Journal of cachexia, sarcopenia and muscle 2025 Feb;16(1):e13717
Journal of cachexia, sarcopenia and muscle 2025 Feb;16(1):e13717
Hydroxysafflor yellow A attenuates the inflammatory response in cerebral ischemia-reperfusion injured mice by regulating microglia polarization per SIRT1-mediated HMGB1/NF-κB signaling pathway.
Yao M, Liu Y, Meng D, Zhou X, Chang D, Li L, Wang N, Huang Q
International immunopharmacology 2025 Feb 6;147:114040
International immunopharmacology 2025 Feb 6;147:114040
Ergothioneine improves healthspan of aged animals by enhancing cGPDH activity through CSE-dependent persulfidation.
Petrovic D, Slade L, Paikopoulos Y, D'Andrea D, Savic N, Stancic A, Miljkovic JL, Vignane T, Drekolia MK, Mladenovic D, Sutulovic N, Refeyton A, Kolakovic M, Jovanovic VM, Zivanovic J, Miler M, Vellecco V, Brancaleone V, Bucci M, Casey AM, Yu C, Kasarla SS, Smith KW, Kalfe-Yildiz A, Stenzel M, Miranda-Vizuete A, Hergenröder R, Phapale P, Stanojlovic O, Ivanovic-Burmazovic I, Vlaski-Lafarge M, Bibli SI, Murphy MP, Otasevic V, Filipovic MR
Cell metabolism 2025 Feb 4;37(2):542-556.e14
Cell metabolism 2025 Feb 4;37(2):542-556.e14
Ribes diacanthum Pall modulates bile acid homeostasis and oxidative stress in cholestatic mice by activating the SIRT1/FXR and Keap1/Nrf2 signaling pathways.
Bayoude A, Zhang J, Shen Y, Tilyek A, Chai C
Journal of ethnopharmacology 2025 Feb 27;342:119400
Journal of ethnopharmacology 2025 Feb 27;342:119400
Puerarin reduces susceptibility to ventricular arrhythmias and inhibits ferroptosis via Sirt1/Nrf2 signaling in high-fat-diet rats.
Jiang S, Qiu S, Mu Y, Liu C, Han Y, Jiang J, Wang Y
Free radical biology & medicine 2025 Feb 1;227:472-484
Free radical biology & medicine 2025 Feb 1;227:472-484
NAD(+) Enhanced Mesenchymal Stromal Cells Effect on Muscle Atrophy by Improving SIRT1-Mediated Mitochondrial Function via NAMPT.
Song J, Sun Y, Zang N, Liu X, Chen J, Wang K, Xia L, Chen J, Zhao R, Liu F, Hou X, Chen L, Cheng J, Zhang W
Journal of cachexia, sarcopenia and muscle 2025 Dec;16(6):e70142
Journal of cachexia, sarcopenia and muscle 2025 Dec;16(6):e70142
Hesperidin Reverses Oxidative Stress-Induced Damage in Kidney Cells by Modulating Antioxidant, Longevity, and Senescence-Related Genes.
Buakaew S, Sakonsinsiri C, Lert-Itthiporn W, Cha'on U, Rudtanatip T, Kraiklang R, Kaewlert W, Rattanaseth P, Pakdeechote P, Thanan R
Biomedicines 2025 Dec 9;13(12)
Biomedicines 2025 Dec 9;13(12)
Effect of Food Migrations of PEEK-Modified Atmosphere Packaging Materials on Mitochondrial Damage via PGC-1α/Nrf2 Signaling Pathway.
Guo S, Li K, Li W, Huang H, Zhang Y, Zhou Q, He Q, He Z, Wu W, Yang X, Wei Q
Toxics 2025 Dec 5;13(12)
Toxics 2025 Dec 5;13(12)
The Ku80-p53-SIRT1 axis in DNA damage response contributes to sporadic and familial ALS and FTD.
Jun YW, Lee S, Almeida S, Freude KK, Ichida JK, Gao FB
Nature communications 2025 Dec 20;17(1):1007
Nature communications 2025 Dec 20;17(1):1007
Role of Esketamine in Attenuating Neuroinflammation and Improving Postoperative Cognitive Function via Autophagy Activation Through PARP1 Targeting.
Zhao C, Liu J, Zhao S, Liu P, Li Z, Li Y, Dong R, Wang XL
Physiological research 2025 Dec 2;74(5):871-884
Physiological research 2025 Dec 2;74(5):871-884
Exploring neuroprotective effects of Chuanzhitongluo capsule on an alzheimer's disease rat model.
Sun Y, Shao M, Du L, Gan Y, Guan Y, Cheng G, Li S, Jin H, Li B, Zhang G, Yan S, Xiao X
Metabolic brain disease 2025 Dec 19;41(1):5
Metabolic brain disease 2025 Dec 19;41(1):5
Interleukin 13 alleviates traumatic brain injury by promoting pericyte autophagy.
Ya D, Guo B, Jiang Y, Deng J, Tian N, Li X, Chen W, Liao R
Free radical biology & medicine 2025 Dec 16;241:384-410
Free radical biology & medicine 2025 Dec 16;241:384-410
Sirt1 attenuates necrotizing enterocolitis via Hif-1α deacetylation-mediated suppression of Bnip3-Dependent mitophagy.
Zhu L, Huang M, He L, Rong Z
Free radical biology & medicine 2025 Dec 16;241:150-160
Free radical biology & medicine 2025 Dec 16;241:150-160
Phosphorylation of PA28γ by CK2 kinase facilitates HNSCC tumor formation and progression.
Sun S, Zhong B, Wang Y, Li Z, Jiang Y, Ji N, Feng X, Liu R, Zeng X, Zhou X, Li C, Zhao H, Li J, Chen Q
Nature communications 2025 Dec 10;17(1):443
Nature communications 2025 Dec 10;17(1):443
Liraglutide attenuates high glucose-induced endothelial cell senescence and dysfunction via SIRT1-mediated deacetylation of p53/p65.
Zhong W, Yang Y, Wang Y
Tissue & cell 2025 Aug;95:102882
Tissue & cell 2025 Aug;95:102882
Improvement effect of Shengxian Decoction on cardiac toxicity induced by arsenic trioxide in rats.
Wang Y, Hou J, Yu Y, He K, Guo H, Liu N, Wang H, Song Y, Ma D
Journal of ethnopharmacology 2025 Aug 29;352:120163
Journal of ethnopharmacology 2025 Aug 29;352:120163
RhFGF21 protects the skin from UVB irradiation in diabetic mice through the inhibition of epidermal cell apoptosis and macrophage-mediated inflammation via the SIRT1 signaling pathway.
Ye S, Lin J, Zhang Y, Li J, Wang Y, Liang F, Wu J, Xu Y, Lin L, Zhao Y
Biochimica et biophysica acta. Molecular basis of disease 2025 Apr;1871(4):167724
Biochimica et biophysica acta. Molecular basis of disease 2025 Apr;1871(4):167724
New insights into ovarian regression-related mitochondrial dysfunction in the late-laying period.
Gu T, Liu J, Zeng T, Chen L, Tian Y, Xu W, Lu L
Poultry science 2025 Apr;104(4):104938
Poultry science 2025 Apr;104(4):104938
Loss of NgBR causes neuronal damage through decreasing KAT7-mediated RFX1 acetylation and FGF1 expression.
Hu Y, Ma Y, Liu L, Hong Y, Wang G, Tang B, Guo J, Yang P, Cao Y, Ren H
Cellular and molecular life sciences : CMLS 2025 Apr 7;82(1):140
Cellular and molecular life sciences : CMLS 2025 Apr 7;82(1):140
LNCAROD was stabilized through N(6)-methyladenosine methylation and exerted its anticancer effects in lung squamous cell carcinoma by inhibiting SIRT1 activity via CCAR2.
Yan Q, Wong W, Lei J, Liang D, Yang J, Gong L, Berardi R, Dai S, Wang J
Translational lung cancer research 2025 Apr 30;14(4):1351-1370
Translational lung cancer research 2025 Apr 30;14(4):1351-1370
Synergistic mechanism of olaparib and cisplatin on breast cancer elucidated by network pharmacology.
Niu Q, Zhang T
Scientific reports 2025 Apr 28;15(1):14800
Scientific reports 2025 Apr 28;15(1):14800
TACC3 enhances glycolysis in bladder cancer cells through inducing acetylation of c-Myc.
Lin Z, Liang F, Hong G, Jiang X, Zhang Q, Wang M
Cell death & disease 2025 Apr 17;16(1):311
Cell death & disease 2025 Apr 17;16(1):311
Nicotinamide mononucleotide promotes female germline stem cell proliferation by activating the H4K16ac-Hmgb1-Fyn-PLD signaling pathway through epigenetic remodeling.
Zhou H, Liu Y, Tian GG, Wu J
Cell & bioscience 2025 Apr 17;15(1):48
Cell & bioscience 2025 Apr 17;15(1):48
Nicotinamide ameliorates podocyte injury and albuminuria in adriamycin-induced nephropathy.
Takahashi K, Sato E, Yamakoshi S, Ogane M, Sekimoto A, Ishikawa T, Kisu K, Oe Y, Okamoto K, Miyazaki M, Tanaka T, Takahashi N
American journal of physiology. Renal physiology 2025 Apr 1;328(4):F501-F516
American journal of physiology. Renal physiology 2025 Apr 1;328(4):F501-F516
Young TSPC-Derived Exosomal circPVT1 Ameliorates Aging-Impaired Cell Function via SIRT1/NF-κB.
Han W, Gu D, Li X, Chen H, Tao X, Chen L
Tissue engineering. Part C, Methods 2024;30(6):248-254
Tissue engineering. Part C, Methods 2024;30(6):248-254
Forsythoside B alleviates cerebral ischemia-reperfusion injury via inhibiting NLRP3 inflammasome mediated by SIRT1 activation.
Li Q, Zhang C, Sun X, Wang M, Zhang Z, Chen R, Sun X
PloS one 2024;19(6):e0305541
PloS one 2024;19(6):e0305541
Jagged 2 inhibition attenuates hypoxia-induced mitochondrial damage and pulmonary hypertension through Sirtuin 1 signaling.
Liu H, Pan Z, Wu X, Gong C, Hu J
PloS one 2024;19(1):e0297525
PloS one 2024;19(1):e0297525
Integrated Network Pharmacology and in vivo Experimental Validation Approach to Explore the Potential Antioxidant Effects of Annao Pingchong Decoction in Intracerebral Hemorrhage Rats.
Zhou X, Wang X, Li J, Zhang M, Yang Y, Lei S, He Y, Yang H, Zhou D, Guo C
Drug design, development and therapy 2024;18:699-717
Drug design, development and therapy 2024;18:699-717
Inflammation Can Be a High-Risk Factor for Mucosal Nonunion of MRONJ by Regulating SIRT1 Signaling When Treated with an Oncologic Dose of Zoledronate.
Zhu S, Cui Y, Zhang W, Ji Y, Li L, Luo S, Cui J, Li M
Drug design, development and therapy 2024;18:2793-2812
Drug design, development and therapy 2024;18:2793-2812
NAD-Dependent Protein Deacetylase Sirtuin-1 Mediated Mitophagy Regulates Early Brain Injury After Subarachnoid Hemorrhage.
Wang G, Lin N
Journal of inflammation research 2024;17:1971-1981
Journal of inflammation research 2024;17:1971-1981
Diosgenin derivative ML5 attenuates MPTP-induced neuronal impairment via regulating AMPK/PGC-1α-mediated mitochondrial biogenesis and fusion/fission.
Fan JJ, Ding WD, Liang YF, Wei YX, Huang Y, Ma L, Wang R
American journal of translational research 2024;16(8):3582-3598
American journal of translational research 2024;16(8):3582-3598
Inhibition SIRT1 to regulate FOXP3 or RORγt can restore the balance of Treg/Th17 axis in ulcerative colitis and enhance the anti-inflammatory effect of moxibustion.
Zhu Y, Wang Y, Zuo X, Liu S, Cao L, Wang J, Yang Q, Huang Q, Huang Q, Tian M, Ping Y, Wu Q
Frontiers in immunology 2024;15:1525469
Frontiers in immunology 2024;15:1525469
The role of SIRT1-FXR signaling pathway in valproic acid induced liver injury: a quantitative targeted metabolomic evaluation in epileptic children.
Zhao M, Li G, Zhao L
Frontiers in pharmacology 2024;15:1477619
Frontiers in pharmacology 2024;15:1477619
The mitochondria‒paraspeckle axis regulates the survival of transplanted stem cells under oxidative stress conditions.
Zhao M, Liu S, Wang Y, Lv K, Lou P, Zhou P, Zhu J, Li L, Cheng J, Lu Y, Liu J
Theranostics 2024;14(4):1517-1533
Theranostics 2024;14(4):1517-1533
Nicorandil mitigates arsenic trioxide-induced lung injury via modulating vital signalling pathways SIRT1/PGC-1α/TFAM, JAK1/STAT3, and miRNA-132 expression.
Abdel-Wahab BA, Zafaar D, Habeeb MS, El-Shoura EAM
British journal of pharmacology 2024 Sep;181(17):3215-3231
British journal of pharmacology 2024 Sep;181(17):3215-3231
Aspirin exposure coupled with hypoxia interferes energy metabolism, antioxidant and autophagic processes and causes liver injury in estuarine goby Mugilogobius chulae.
Wang Y, Zhao Y, Gong W, Hou Y, Ren J, Duan C, Zhang H, Nie X, Li J
Journal of hazardous materials 2024 Sep 5;476:135071
Journal of hazardous materials 2024 Sep 5;476:135071
BAP1 regulates HSF1 activity and cancer immunity in pancreatic cancer.
Yuan W, Zhang Q, Zhao Y, Xia W, Yin S, Liang X, Chen T, Li G, Liu Y, Liu Z, Huang J
Journal of experimental & clinical cancer research : CR 2024 Sep 30;43(1):275
Journal of experimental & clinical cancer research : CR 2024 Sep 30;43(1):275
LINC00887 promotes GCN5-dependent H3K27cr level and CRC metastasis via recruitment of YEATS2 and enhancing ETS1 expression.
Liao M, Zheng W, Wang Y, Li M, Sun X, Liu N, Yao J, Dong F, Wang Q, Ma Y, Mou J
Cell death & disease 2024 Sep 30;15(9):711
Cell death & disease 2024 Sep 30;15(9):711
Melatonin Regulates the Expression of VEGF and HOXA10 in Bovine Endometrial Epithelial Cells through the SIRT1/PI3K/AKT Pathway.
Li Q, Tang Y, Chen Y, Li B, Wang H, Liu S, Adeniran SO, Zheng P
Animals : an open access journal from MDPI 2024 Sep 25;14(19)
Animals : an open access journal from MDPI 2024 Sep 25;14(19)
Sirtuin 1 Inhibits Fatty Acid Synthesis through Forkhead Box Protein O1-Mediated Adipose Triglyceride Lipase Expression in Goat Mammary Epithelial Cells.
He Q, Yao W, Lv L, Zhang X, Wu J, Luo J
International journal of molecular sciences 2024 Sep 14;25(18)
International journal of molecular sciences 2024 Sep 14;25(18)
Unveiling the regulatory role of SIRT1 in the oxidative stress response of bovine mammary cells.
Zhang Y, Liu J, Yuan S, Liu S, Zhang M, Hu H, Cao Y, Hu G, Fu S, Guo W
Journal of dairy science 2024 Oct;107(10):8722-8735
Journal of dairy science 2024 Oct;107(10):8722-8735
The transcription factor PPARA mediates SIRT1 regulation of NCOR1 to protect damaged heart cells.
Wang M, Zhou F, Luo Y, Deng X, Chen X, Yi Q
Cardiovascular diagnosis and therapy 2024 Oct 31;14(5):832-847
Cardiovascular diagnosis and therapy 2024 Oct 31;14(5):832-847
Human adipose and umbilical cord mesenchymal stem cell-derived extracellular vesicles mitigate photoaging via TIMP1/Notch1.
Zhang H, Xiao X, Wang L, Shi X, Fu N, Wang S, Zhao RC
Signal transduction and targeted therapy 2024 Oct 30;9(1):294
Signal transduction and targeted therapy 2024 Oct 30;9(1):294
Luteolin Protects against Vascular Calcification by Modulating SIRT1/CXCR4 Signaling Pathway and Promoting Autophagy.
Yu X, Xu L, Su C, Wang C, Wang Z, Wang Y, Lu X, Sun H
The AAPS journal 2024 Oct 22;26(6):111
The AAPS journal 2024 Oct 22;26(6):111
Black phosphorus nanosheets induce autophagy dysfunction by a size- and surface modification-related impairment of lysosomes in macrophages.
Deng S, Zhao Q, Liu D, Xiong Z, Zhang S, Zhang X, Wu F, Xing B
Ecotoxicology and environmental safety 2024 Oct 15;285:117073
Ecotoxicology and environmental safety 2024 Oct 15;285:117073
Discovery of SIRT1-Activating Hydrogen Sulfide Donating Derivatives for Efficient Resistant of Myocardial Ischemic Injury.
Wang S, Feng D, Wang W, Zheng C, Liang C, Li S, Li H, Xu F, Cao H, Hua H, Cheng M, Li D
Journal of medicinal chemistry 2024 Oct 10;67(19):17657-17675
Journal of medicinal chemistry 2024 Oct 10;67(19):17657-17675
Exploring the Effects of Whole Food-Based Dragon Fruit on Metabolic Disorders in High-Fat Diet-Induced Mice.
Ho PY, Lin PX, Koh YC, Lin WS, Tang KL, Chen YH, Weerawatanakorn M, Pan MH
Molecular nutrition & food research 2024 Nov;68(21):e2400604
Molecular nutrition & food research 2024 Nov;68(21):e2400604
SIRT1, a target of miR-708-3p, alleviates fluoride-induced neuronal damage via remodeling mitochondrial network dynamics.
Zhao Q, Zhou GY, Niu Q, Chen JW, Li P, Tian ZY, Li DJ, Xia T, Zhang S, Wang AG
Journal of advanced research 2024 Nov;65:197-210
Journal of advanced research 2024 Nov;65:197-210
6-Gingerol improves lipid metabolism disorders in skeletal muscle by regulating AdipoR1/AMPK signaling pathway.
Peng Z, Zeng Y, Zeng X, Tan Q, He Q, Wang S, Wang J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Nov;180:117462
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Nov;180:117462
Resistance Exercise Improves Glycolipid Metabolism and Mitochondrial Biogenesis in Skeletal Muscle of T2DM Mice via miR-30d-5p/SIRT1/PGC-1α Axis.
Zheng L, Rao Z, Wu J, Ma X, Jiang Z, Xiao W
International journal of molecular sciences 2024 Nov 19;25(22)
International journal of molecular sciences 2024 Nov 19;25(22)
Tat-Beclin-1 Peptide Ameliorates Metabolic Dysfunction-Associated Steatotic Liver Disease by Enhancing Hepatic Autophagy.
Chen CL, Huang FF, Lin HF, Wu CC, Ni YH, Lin YC
International journal of molecular sciences 2024 Nov 18;25(22)
International journal of molecular sciences 2024 Nov 18;25(22)
Acetylation of FOXO1 is involved in cadmium-induced rat kidney injury via mediating autophagosome-lysosome fusion blockade and autophagy inhibition.
Ruan Y, Xue Y, Zhang P, Jia J
Ecotoxicology and environmental safety 2024 Nov 15;287:117253
Ecotoxicology and environmental safety 2024 Nov 15;287:117253
Taraxerone inhibits M1 polarization and alleviates sepsis-induced acute lung injury by activating SIRT1.
Deng L, Xie W, Lin M, Xiong D, Huang L, Zhang X, Qian R, Huang X, Tang S, Liu W
Chinese medicine 2024 Nov 14;19(1):159
Chinese medicine 2024 Nov 14;19(1):159
SIRT1-Dependent Neuroprotection by Resveratrol in TOCP-Induced Spinal Cord Injury: Modulation of ER Stress and Autophagic Flux.
Tian X, Ou Y, Shi S, Zhou Q, Long S, Xiang Y, Zhao W, Long D
Toxics 2024 Nov 11;12(11)
Toxics 2024 Nov 11;12(11)
Hydrogen sulfide upregulates SIRT1 to inhibit ox-HDL-induced endothelial cell damage and mitochondrial dysfunction.
Zhao Y, Wang Y, Zheng H, Xu Q, Zhou K, Liu H, Xia Y, Wei DH, Jiang M, Tang ZH, Liu LS, Zheng H, Jiang Z
Nitric oxide : biology and chemistry 2024 Nov 1;152:78-89
Nitric oxide : biology and chemistry 2024 Nov 1;152:78-89
Myricanol improves metabolic profiles in dexamethasone induced lipid and protein metabolism disorders in mice.
Li T, Hu X, Fan L, Yang Y, He K
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 May;174:116557
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 May;174:116557
Rap1GAP exacerbates myocardial infarction by regulating the AMPK/SIRT1/NF-κB signaling pathway.
Shan T, Li X, Xie W, Wang S, Gao Y, Zheng Y, Su G, Li Y, Zhao Z
Cellular signalling 2024 May;117:111080
Cellular signalling 2024 May;117:111080
Development and Application of the CRISPR-dcas13d-eIF4G Translational Regulatory System to Inhibit Ferroptosis in Calcium Oxalate Crystal-Induced Kidney Injury.
He Z, Song C, Li S, Dong C, Liao W, Xiong Y, Yang S, Liu Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 May;11(17):e2309234
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 May;11(17):e2309234
Inhibition of SIRT1 in the nucleus accumbens attenuates heroin addiction-related behavior by decreasing D1 neuronal autophagy.
Huang Y, Liu M, Zheng Z, Lu R, Li C, Su M, Li Y, Xia B
Neuroreport 2024 May 8;35(7):486-498
Neuroreport 2024 May 8;35(7):486-498
FTH1 overexpression using a dCasRx translation enhancement system protects the kidney from calcium oxalate crystal-induced injury.
He Z, Dong C, Song T, Zhou J, Xu T, He R, Li S
Cellular & molecular biology letters 2024 May 7;29(1):65
Cellular & molecular biology letters 2024 May 7;29(1):65
Senegenin Attenuates Pulmonary Fibrosis by Inhibiting Oxidative-Stress-Induced Epithelial Cell Senescence through Activation of the Sirt1/Pgc-1α Signaling Pathway.
Zeng Q, Luo Y, Sang X, Liao M, Wen B, Hu Z, Sun M, Luo Z, Huang X, Liu W, Tang S
Antioxidants (Basel, Switzerland) 2024 May 31;13(6)
Antioxidants (Basel, Switzerland) 2024 May 31;13(6)
PM(2.5) induces cardiac defects via AHR-SIRT1-PGC-1α mediated mitochondrial damage.
Chen J, Zhang M, Aniagu S, Jiang Y, Chen T
Environmental toxicology and pharmacology 2024 Mar;106:104393
Environmental toxicology and pharmacology 2024 Mar;106:104393
Nicotine regulates abnormal macrophage polarization and trophoblast invasion associated with preterm labor via the α7nAChR/SIRT1 axis.
Ye A, Li L, Chen H, Tao P, Lou S
Placenta 2024 Mar 6;147:42-51
Placenta 2024 Mar 6;147:42-51
Curculigoside Attenuates Endoplasmic Reticulum Stress-Induced Epithelial Cell and Fibroblast Senescence by Regulating the SIRT1-P300 Signaling Pathway.
Xie W, Deng L, Qian R, Huang X, Liu W, Tang S
Antioxidants (Basel, Switzerland) 2024 Mar 29;13(4)
Antioxidants (Basel, Switzerland) 2024 Mar 29;13(4)
Caffeic acid phenethyl ester inhibits neuro-inflammation and oxidative stress following spinal cord injury by mitigating mitochondrial dysfunction via the SIRT1/PGC1α/DRP1 signaling pathway.
Zhang Y, Deng Q, Hong H, Qian Z, Wan B, Xia M
Journal of translational medicine 2024 Mar 25;22(1):304
Journal of translational medicine 2024 Mar 25;22(1):304
The Effectiveness of Four Nicotinamide Adenine Dinucleotide (NAD(+)) Precursors in Alleviating the High-Glucose-Induced Damage to Hepatocytes in Megalobrama amblycephala: Evidence in NAD(+) Homeostasis, Sirt1/3 Activation, Redox Defense, Inflammatory Response, Apoptosis, and Glucose Metabolism.
Dong Y, Wang X, Wei L, Liu Z, Chu X, Xiong W, Liu W, Li X
Antioxidants (Basel, Switzerland) 2024 Mar 22;13(4)
Antioxidants (Basel, Switzerland) 2024 Mar 22;13(4)
Deacetylase Sirtuin 1 mitigates type I IFN- and type II IFN-induced signaling and antiviral immunity.
Yu S-S, Tang R-C, Zhang A, Geng S, Yu H, Zhang Y, Sun X-Y, Zhang J
Journal of virology 2024 Mar 19;98(3):e0008824
Journal of virology 2024 Mar 19;98(3):e0008824
MED1 IDR acetylation reorganizes the transcription preinitiation complex, rewires 3D chromatin interactions and reprograms gene expression.
Lin R, Barrows D, Mo Y, Onikubo T, Zhang Z, Roeder RG
bioRxiv : the preprint server for biology 2024 Mar 18;
bioRxiv : the preprint server for biology 2024 Mar 18;
BNC1 deficiency induces mitochondrial dysfunction-triggered spermatogonia apoptosis through the CREB/SIRT1/FOXO3 pathway: the therapeutic potential of nicotinamide riboside and metformin†.
Ni F, Wang F, Li J, Liu Y, Sun X, Chen J, Li J, Zhang Y, Jin J, Ye X, Tu M, Chen J, Chen C, Zhang D
Biology of reproduction 2024 Mar 13;110(3):615-631
Biology of reproduction 2024 Mar 13;110(3):615-631
Cluster of Differentiation-44-Targeting Prussian Blue Nanoparticles Onloaded with Colchicine for Atherosclerotic Plaque Regression in a Mice Model.
Zhu Y, Fang Y, Wang Y, Han D, Liu J, Tian L, Xu M, Wang Y, Cao F
ACS biomaterials science & engineering 2024 Mar 11;10(3):1530-1543
ACS biomaterials science & engineering 2024 Mar 11;10(3):1530-1543
Acupuncture alleviates CUMS-induced depression-like behaviors of rats by regulating oxidative stress, neuroinflammation and ferroptosis.
Shen J, Hao C, Yuan S, Chen W, Tong T, Chen Y, Shahzad Aslam M, Yan S, Li J, Zeng J, Liu S, Chen Y, Jiang Y, Li P, Meng X
Brain research 2024 Mar 1;1826:148715
Brain research 2024 Mar 1;1826:148715
Structural characterization and improves cognitive disorder in ageing mice of a glucomannan from Dendrobium huoshanense.
Zhang X, Ge R, Wu J, Cai X, Deng G, Lv J, Ma M, Yu N, Yao L, Peng D
International journal of biological macromolecules 2024 Jun;269(Pt 1):131995
International journal of biological macromolecules 2024 Jun;269(Pt 1):131995
Glucose regulates the HMGB1 signaling pathway through SIRT1 in glioma.
Wang Y, Wang S, Wang Y, Wang C, Tang Y, Zhang C, Hou S, Yu D, Lin N
Cellular signalling 2024 Jun;118:111137
Cellular signalling 2024 Jun;118:111137
Inhibiting Pink1/Parkin-mediated mitophagy enhances the anticancer effects of quercetin in hepatocellular carcinomaf.
Chen F
Biochemical and biophysical research communications 2024 Jun 18;712-713:149899
Biochemical and biophysical research communications 2024 Jun 18;712-713:149899
Menaquinone-4 alleviates hypoxic-ischemic brain damage in neonatal rats by reducing mitochondrial dysfunction via Sirt1-PGC-1α-TFAM signaling pathway.
Feng X, Zheng Y, Mao N, Shen M, Chu L, Fang Y, Pang M, Wang Z, Lin Z
International immunopharmacology 2024 Jun 15;134:112257
International immunopharmacology 2024 Jun 15;134:112257
TBK1 pharmacological inhibition mitigates osteoarthritis through attenuating inflammation and cellular senescence in chondrocytes.
Lu R, Qu Y, Wang Z, He Z, Xu S, Cheng P, Lv Z, You H, Guo F, Chen A, Zhang J, Liang S
Journal of orthopaedic translation 2024 Jul;47:207-222
Journal of orthopaedic translation 2024 Jul;47:207-222
Carnosol prevents cardiac remodeling and ventricular arrhythmias in pressure overload-induced heart failure mice.
Fang Z, Lu M, Huang R, Wang G, Yushanjiang F, Jiang X, Li J
Phytotherapy research : PTR 2024 Jul;38(7):3763-3781
Phytotherapy research : PTR 2024 Jul;38(7):3763-3781
Taraxerone exerts antipulmonary fibrosis effect through Smad signaling pathway and antioxidant stress response in a Sirtuin1-dependent manner.
Chen Z, Xie W, Tang S, Lin M, Ren L, Huang X, Deng L, Qian R, Wang Z, Xiong D, Xie P, Liu W
Phytotherapy research : PTR 2024 Jul;38(7):3720-3735
Phytotherapy research : PTR 2024 Jul;38(7):3720-3735
Mechanism Research of DHEA Treatment Improving Diminished Ovarian Reserve by Attenuating the AMPK-SIRT1 Signaling and Mitophagy.
Ma Q, Shen M, Wu J, Ye C, Tan Y
Reproductive sciences (Thousand Oaks, Calif.) 2024 Jul;31(7):2059-2072
Reproductive sciences (Thousand Oaks, Calif.) 2024 Jul;31(7):2059-2072
miR-485-3p targets SIRT1 in vascular smooth muscle cells mediating the occurrence of aortic dissection.
Xie Y, Xie L, Qiu Z, He J, Jiang F, Cai M, Lin Y, Chen L
Journal of cellular and molecular medicine 2024 Jul;28(13):e18454
Journal of cellular and molecular medicine 2024 Jul;28(13):e18454
Pinocembrin's protective effect against acute pancreatitis in a rat model: The correlation between TLR4/NF-κB/NLRP3 and miR-34a-5p/SIRT1/Nrf2/HO-1 pathways.
Ali BM, Al-Mokaddem AK, Selim HMRM, Alherz FA, Saleh A, Hamdan AME, Ousman MS, El-Emam SZ
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jul;176:116854
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jul;176:116854
Luteolin alleviates cadmium-induced metabolism disorder through antioxidant and anti-inflammatory mechanisms in chicken kidney.
Wang X, Zhang K, Ali W, Li J, Huang Q, Liu D, Liu G, Ran D, Liu Z
Poultry science 2024 Jul;103(7):103817
Poultry science 2024 Jul;103(7):103817
Dulaglutide restores endothelial progenitor cell levels in diabetic mice and mitigates high glucose-induced endothelial injury through SIRT1-mediated mitochondrial fission.
Mei X, Li Y, Wu J, Liao L, Lu D, Qiu P, Yang HL, Tang MW, Liang XY, Liu D
Biochemical and biophysical research communications 2024 Jul 5;716:150002
Biochemical and biophysical research communications 2024 Jul 5;716:150002
Ginsenoside Rb1 regulates CPT1A deacetylation to inhibit intramuscular fat infiltration after rotator cuff tear.
Yin Y, Wang Z, Yang Y, Shen M, Hu H, Chen C, Zhou H, Li Z, Wu S
iScience 2024 Jul 19;27(7):110331
iScience 2024 Jul 19;27(7):110331
Weissella paramesenteroides NRIC1542 inhibits dextran sodium sulfate-induced colitis in mice through regulating gut microbiota and SIRT1/NF-κB signaling pathway.
Li S, Chen J, Zheng Y, Zhang Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jul 15;38(13):e23791
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jul 15;38(13):e23791
Overexpression of SESN1 improves mitochondrial damage and mitophagy, a potential therapeutic strategy for cognitive dysfunction after anaesthesia.
Sun L, Hong X, Wang D, Li Y
The European journal of neuroscience 2024 Jan;59(2):208-219
The European journal of neuroscience 2024 Jan;59(2):208-219
Electroacupuncture ameliorates chronic unpredictable mild stress-induced depression-like behavior and cognitive impairment through suppressing oxidative stress and neuroinflammation in rats.
Tong T, Hao C, Shen J, Liu S, Yan S, Aslam MS, Chen Y, Chen W, Li J, Li Y, Zeng J, Li M, You Z, Gulizhaerkezi T, Wei S, Zhu A, Meng X
Brain research bulletin 2024 Jan;206:110838
Brain research bulletin 2024 Jan;206:110838
Protectin D1 ameliorates non-compressive lumbar disc herniation through SIRT1-mediated CGRP signaling.
Zhu YC, Zhang Y, Gao X, Li LX, Tang YR, Wang YH
Molecular pain 2024 Jan-Dec;20:17448069241232349
Molecular pain 2024 Jan-Dec;20:17448069241232349
TIMELESS promotes reprogramming of glucose metabolism in oral squamous cell carcinoma.
Chen Y, Han Z, Zhang L, Gao C, Wei J, Yang X, Han Y, Li Y, Zhang C, Wei Y, Dong J, Xun W, Sun W, Zhang T, Zhang H, Chen J, Yuan P
Journal of translational medicine 2024 Jan 4;22(1):21
Journal of translational medicine 2024 Jan 4;22(1):21
LncRNA HOTAIR regulates autophagy and proliferation mechanisms in premature ovarian insufficiency through the miR-148b-3p/ATG14 axis.
Luo C, Wei L, Qian F, Bo L, Gao S, Yang G, Mao C
Cell death discovery 2024 Jan 24;10(1):44
Cell death discovery 2024 Jan 24;10(1):44
The promotion of fatty acid β-oxidation by hesperidin via activating SIRT1/PGC1α to improve NAFLD induced by a high-fat diet.
Nie T, Wang X, Li A, Shan A, Ma J
Food & function 2024 Jan 2;15(1):372-386
Food & function 2024 Jan 2;15(1):372-386
Quercetin stimulates trophoblast fusion via the mitochondrial function.
Yoshida K, Kusama K, Shinohara G, Sato S, Yoshie M, Tamura K
Scientific reports 2024 Jan 2;14(1):287
Scientific reports 2024 Jan 2;14(1):287
The SIRT1/Nrf2 signaling pathway mediates the anti-pulmonary fibrosis effect of liquiritigenin.
Hua Q, Ren L
Chinese medicine 2024 Jan 18;19(1):12
Chinese medicine 2024 Jan 18;19(1):12
Decoupling NAD(+) metabolic dependency in chondrosarcoma by targeting the SIRT1-HIF-2α axis.
Suh J, Kim H, Min J, Yeon HJ, Hemberg M, Scimeca L, Wu MR, Kang HG, Kim YJ, Kim JH
Cell reports. Medicine 2024 Jan 16;5(1):101342
Cell reports. Medicine 2024 Jan 16;5(1):101342
Tryptophanylation of insulin receptor by WARS attenuates insulin signaling.
Sun WX, Zhang KH, Zhou Q, Hu SH, Lin Y, Xu W, Zhao SM, Yuan YY
Cellular and molecular life sciences : CMLS 2024 Jan 12;81(1):25
Cellular and molecular life sciences : CMLS 2024 Jan 12;81(1):25
Network pharmacology and experimental validation on yangjing zhongyu decoction against diminished ovarian reserve.
Liu J, Wei B, Ma Q, Shi D, Pan X, Liu Z, Li J, Zhao P
Journal of ethnopharmacology 2024 Jan 10;318(Pt B):117023
Journal of ethnopharmacology 2024 Jan 10;318(Pt B):117023
The role and mechanism of RIPK1 in vascular endothelial dysfunction in chronic kidney disease.
Wang C, Chen H, Su H, Sheng Q, Lang Y, Yu Q, Lv Z, Wang R
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Feb;38(2):e23446
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Feb;38(2):e23446
Safranal acts as a neurorestorative agent in rats with cerebral ischemic stroke via upregulating SIRT1.
He F, Chen C, Wang Y, Wang S, Lyu S, Jiao J, Huang G, Yang J
Experimental and therapeutic medicine 2024 Feb;27(2):71
Experimental and therapeutic medicine 2024 Feb;27(2):71
Gestational exposure to bisphenol AF causes endocrine disorder of corpus luteum by altering ovarian SIRT-1/Nrf2/NF-kB expressions and macrophage proangiogenic function in mice.
Lu S, Liu M, Liu H, Yang C, Zhu J, Ling Y, Kuang H
Biochemical pharmacology 2024 Feb;220:115954
Biochemical pharmacology 2024 Feb;220:115954
Ginsenoside Rg5 inhibits lipid accumulation and hepatocyte apoptosis via the Notch1 signaling pathway in NASH mice.
Li N, Zhu C, Fu R, Ma X, Duan Z, Fan D
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Feb;124:155287
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Feb;124:155287
Ginsenoside Rb1 prevents age-related endothelial senescence by modulating SIRT1/caveolin-1/enos signaling pathway.
Zhou B, Sh G, Xie D, Zhao X, Hao B, Liu D, Wang M, Wu L, Lin L, Qian X
Heliyon 2024 Feb 15;10(3):e24586
Heliyon 2024 Feb 15;10(3):e24586
Txnip promotes autophagic apoptosis in diabetic cardiomyopathy by upregulating FoxO1 and its acetylation.
Zhang Y, Li B, Fu Y, Cai H, Zheng Y
Cellular signalling 2024 Dec;124:111469
Cellular signalling 2024 Dec;124:111469
CTRP6-mediated cardiac protection in heart failure via the AMPK/SIRT1/PGC-1α signalling pathway.
Fan T, Zhu N, Li M, Wang Z, Lin X
Experimental physiology 2024 Dec;109(12):2031-2045
Experimental physiology 2024 Dec;109(12):2031-2045
SIRT1 Activation Suppresses Corneal Endothelial-Mesenchymal Transition via the TGF-β/Smad2/3 Pathway.
Yu Y, Guo R, Ling J, Xu C, Ma M, Dong X, Wu J, Huang T
Current issues in molecular biology 2024 Dec 6;46(12):13846-13859
Current issues in molecular biology 2024 Dec 6;46(12):13846-13859
Qianyang yuyin granule ameliorates mitochondrial dysfunction of hypertensive myocardial remodeling.
Zheng Y, Fang Y, Luo Y, Fan Y, Fang Z
Journal of ethnopharmacology 2024 Dec 5;335:118610
Journal of ethnopharmacology 2024 Dec 5;335:118610
Efficacy of DHA-enriched phosphatidylserine and its underlying mechanism in alleviating polystyrene nanoplastics-induced hepatotoxicity in mice.
Zhang Y, Zhao Q, Zhao R, Lu Y, Jiang S, Tang Y
International immunopharmacology 2024 Dec 5;142(Pt A):113154
International immunopharmacology 2024 Dec 5;142(Pt A):113154
Bone-protective effects of neutralizing angiopoietin-like protein 4 monoclonal antibody in rheumatoid arthritis.
Ke L, He Q, Qu J, Wang X, Li K, Gong X, Li L, Xu J, Yu Q, Yu H, Lin X, Li J, Tan NS, Sun W, Li L, Zhang P, Cheng W
Molecular therapy : the journal of the American Society of Gene Therapy 2024 Dec 4;32(12):4497-4513
Molecular therapy : the journal of the American Society of Gene Therapy 2024 Dec 4;32(12):4497-4513
Long-term exposure to advanced lipid peroxidation end products impairs cognitive function through microbiota-gut-brain axis.
Wang Y, Fan D, Zhang Y, Wang J, Dong L, Hu Y, Wang S
Food chemistry 2024 Dec 15;461:140864
Food chemistry 2024 Dec 15;461:140864
DEHP regulates ferritinophagy to promote testicular ferroptosis via suppressing SIRT1/PGC-1α pathway.
Zhu Q, Zhai J, Chen Z, Guo Z, Sun X, Li J, Wang N, Yao X, Zhang C, Deng H, Wang S, Yang G
The Science of the total environment 2024 Dec 1;954:176497
The Science of the total environment 2024 Dec 1;954:176497
Dietary sodium sulphate supplementation during mid-to-late gestation improves placental angiogenesis, bile acid metabolism, and serum amino acid concentrations of sows.
Zhou R, Zhe L, Lai SS, Wen HM, Hu L, Zhang XL, Zhuo Y, Xu SY, Lin Y, Feng B, Che LQ, Wu D, Fang ZF
Animal : an international journal of animal bioscience 2024 Aug;18(8):101237
Animal : an international journal of animal bioscience 2024 Aug;18(8):101237
1,8-cineole ameliorates experimental diabetic angiopathy by inhibiting NLRP3 inflammasome-mediated pyroptosis in HUVECs via SIRT2.
Zhang J, Li X, Cui W, Lu D, Zhang Y, Liao J, Guo L, Jiao C, Tao L, Xu Y, Shen X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:117085
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:117085
Phenylsulfate-induced oxidative stress and mitochondrial dysfunction in podocytes are ameliorated by Astragaloside IV activation of the SIRT1/PGC1α /Nrf1 signaling pathway.
Li L, Zou J, Zhou M, Li H, Zhou T, Liu X, Huang Q, Yang S, Xiang Q, Yu R
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:117008
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:117008
Integrative Analysis of Lactylome and Proteome of Hypertrophic Scar To Identify Pathways or Proteins Associated with Disease Development.
Zhang E, Yan Q, Sun Y, Li J, Chen L, Zou J, Zeng S, Jiang J, Li J
Journal of proteome research 2024 Aug 2;23(8):3367-3382
Journal of proteome research 2024 Aug 2;23(8):3367-3382
Mesenchymal stromal cells ameliorate mitochondrial dysfunction in α cells and hyperglucagonemia in type 2 diabetes via SIRT1/FoxO3a signaling.
Song J, Wang L, Wang L, Guo X, He Q, Cui C, Hu H, Zang N, Yang M, Yan F, Liang K, Wang C, Liu F, Sun Y, Sun Z, Lai H, Hou X, Chen L
Stem cells translational medicine 2024 Aug 16;13(8):776-790
Stem cells translational medicine 2024 Aug 16;13(8):776-790
Diosgenin attenuates nonalcoholic hepatic steatosis through the hepatic SIRT1/PGC-1α pathway.
Meng D, Yin G, Chen S, Zhang X, Yu W, Wang L, Liu H, Jiang W, Sun Y, Zhang F
European journal of pharmacology 2024 Aug 15;977:176737
European journal of pharmacology 2024 Aug 15;977:176737
Berberine ameliorates contrast-induced acute kidney injury by regulating HDAC4-FoxO3a axis-induced autophagy: In vivo and in vitro.
Zuo Z, Li Q, Zhou S, Yu R, Wu C, Chen J, Xiao Y, Chen H, Song J, Pan Y, Wang W
Phytotherapy research : PTR 2024 Apr;38(4):1761-1780
Phytotherapy research : PTR 2024 Apr;38(4):1761-1780
Danggui Shaoyao San protects cyclophosphamide-induced premature ovarian failure by inhibiting apoptosis and oxidative stress through the regulation of the SIRT1/p53 signaling pathway.
Chen H, Zhang G, Peng Y, Wu Y, Han X, Xie L, Xu H, Chen G, Liu B, Xu T, Pang M, Hu C, Fan H, Bi Y, Hua Y, Zhou Y, Luo S
Journal of ethnopharmacology 2024 Apr 6;323:117718
Journal of ethnopharmacology 2024 Apr 6;323:117718
Luteolin Alleviates Cadmium-Induced Kidney Injury by Inhibiting Oxidative DNA Damage and Repairing Autophagic Flux Blockade in Chickens.
Zhang K, Li J, Dong W, Huang Q, Wang X, Deng K, Ali W, Song R, Zou H, Ran D, Liu G, Liu Z
Antioxidants (Basel, Switzerland) 2024 Apr 26;13(5)
Antioxidants (Basel, Switzerland) 2024 Apr 26;13(5)
Mechanism of ameliorating cerebral ischemia/reperfusion injury by antioxidant inhibition of autophagy based on network pharmacology and experimental verification.
Zheng Y, Huang Z, Zhao Y, Huang L, Wang J, Li H, Chen X, Wang J, Xie J
Aging 2024 Apr 25;16(8):7474-7486
Aging 2024 Apr 25;16(8):7474-7486
IgG is an aging factor that drives adipose tissue fibrosis and metabolic decline.
Yu L, Wan Q, Liu Q, Fan Y, Zhou Q, Skowronski AA, Wang S, Shao Z, Liao CY, Ding L, Kennedy BK, Zha S, Que J, LeDuc CA, Sun L, Wang L, Qiang L
Cell metabolism 2024 Apr 2;36(4):793-807.e5
Cell metabolism 2024 Apr 2;36(4):793-807.e5
Protective role of forsythoside B in Kawasaki disease-induced cardiac injury: Inhibition of pyroptosis via the SIRT1-NF-κB-p65 signaling pathway.
Yang Y, Wang N, Wang Z, Zhao M, Chen L, Shi Z
Chemico-biological interactions 2024 Apr 1;392:110953
Chemico-biological interactions 2024 Apr 1;392:110953
Apigenin delays postovulatory oocyte aging by reducing oxidative stress through SIRT1 upregulation.
Yao X, Guo P, Li YH, Guo H, Jin Z, Lui W, Yuan J, Gao Q, Wang L, Li Y, Shi J, Zhang X, Cao Q, Xu YN, Kim NH
Theriogenology 2024 Apr 1;218:89-98
Theriogenology 2024 Apr 1;218:89-98
LncRNA GAS5 restrains ISO-induced cardiac fibrosis by modulating mir-217 regulation of SIRT1.
Zhang YH, Sun TT, Liu ZH, Li X, Fan XF, Han LP
Scientific reports 2024 Apr 1;14(1):7652
Scientific reports 2024 Apr 1;14(1):7652
Echinacoside alleviates airway remodeling and inflammation in an ovalbumin-induced neonatal mouse model of asthma by modulating the SIRT1-NF-κB pathway.
Pan Y, Liu Y
Allergologia et immunopathologia 2023;51(4):71-77
Allergologia et immunopathologia 2023;51(4):71-77
Triamcinolone acetonide induces the autophagy of Ag85B-treated WI-38 cells via SIRT1/FOXO3 pathway.
Luo L, Zhou L, Luo L, Feng D, Ding Y, Lu Z, Nie G, Bai L, Xiao Y
Allergologia et immunopathologia 2023;51(2):27-35
Allergologia et immunopathologia 2023;51(2):27-35
ESE-1 mediates lipopolysaccharide-induced BV2 cell inflammation via upregulation of HMGB1 expression.
Lu Y, Ding J, Huang J, Zhao Y
Journal of biosciences 2023;48
Journal of biosciences 2023;48
Puromycin-induced kidney injury and subsequent regeneration in adult zebrafish.
Koun S, Park HJ, Jung SM, Cha JJ, Cha DR, Kang YS
Animal cells and systems 2023;27(1):112-119
Animal cells and systems 2023;27(1):112-119
Diet Control and Swimming Exercise Ameliorate HFD-Induced Cognitive Impairment Related to the SIRT1-NF-κB/PGC-1α Pathways in ApoE-/- Mice.
Wei W, Lin Z, Xu P, Lv X, Lin L, Li Y, Zhou Y, Lu T, Xue X
Neural plasticity 2023;2023:9206875
Neural plasticity 2023;2023:9206875
α-Mangostin Inhibited M1 Polarization of Macrophages/Monocytes in Antigen-Induced Arthritis Mice by Up-Regulating Silent Information Regulator 1 and Peroxisome Proliferators-Activated Receptor γ Simultaneously.
Wu YJ, Zhang SS, Yin Q, Lei M, Wang QH, Chen WG, Luo TT, Zhou P, Ji CL
Drug design, development and therapy 2023;17:563-577
Drug design, development and therapy 2023;17:563-577
MiRNA-Seq reveals key MicroRNAs involved in fat metabolism of sheep liver.
Fei X, Jin M, Yuan Z, Li T, Lu Z, Wang H, Lu J, Quan K, Yang J, He M, Wang T, Wang Y, Wei C
Frontiers in genetics 2023;14:985764
Frontiers in genetics 2023;14:985764
Exercise prevents fatal stress-induced myocardial injury in obese mice.
Dun Y, Hu Z, You B, Du Y, Zeng L, Zhao Y, Liu Y, Wu S, Cui N, Yang F, Liu S
Frontiers in endocrinology 2023;14:1223423
Frontiers in endocrinology 2023;14:1223423
Biomarker identification and pathway analysis of Astragalus membranaceus and Curcuma zedoaria couplet medicines on adenine-induced chronic kidney disease in rats based on metabolomics.
Lu L, Lu J, Chen J, Wang B, Peng H, Peng J, Liu X, Lin F, Xiong G
Frontiers in pharmacology 2023;14:1103527
Frontiers in pharmacology 2023;14:1103527
Pterostilbene Enhances Thermogenesis and Mitochondrial Biogenesis by Activating the SIRT1/PGC-1α/SIRT3 Pathway to Prevent Western Diet-Induced Obesity.
Koh YC, Lin SJ, Hsu KY, Nagabhushanam K, Ho CT, Pan MH
Molecular nutrition & food research 2023 Sep;67(18):e2300370
Molecular nutrition & food research 2023 Sep;67(18):e2300370
α-myosin heavy chain lactylation maintains sarcomeric structure and function and alleviates the development of heart failure.
Zhang N, Zhang Y, Xu J, Wang P, Wu B, Lu S, Lu X, You S, Huang X, Li M, Zou Y, Liu M, Zhao Y, Sun G, Wang W, Geng D, Liu J, Cao L, Sun Y
Cell research 2023 Sep;33(9):679-698
Cell research 2023 Sep;33(9):679-698
Genetic modification of miR-34a enhances efficacy of transplanted human dental pulp stem cells after ischemic stroke.
Wang J, He P, Tian Q, Luo Y, He Y, Liu C, Gong P, Guo Y, Ye Q, Li M
Neural regeneration research 2023 Sep;18(9):2029-2036
Neural regeneration research 2023 Sep;18(9):2029-2036
Dendrobium officinale Kimura & Migo polysaccharide inhibits hyperglycaemia-induced kidney fibrosis via the miRNA-34a-5p/SIRT1 signalling pathway.
Huang C, Yu J, Da J, Dong R, Dai L, Yang Y, Deng Y, Yuan J
Journal of ethnopharmacology 2023 Sep 15;313:116601
Journal of ethnopharmacology 2023 Sep 15;313:116601
Baicalein ameliorates polymyxin B-induced acute renal injury by inhibiting ferroptosis via regulation of SIRT1/p53 acetylation.
Yu M, Li H, Wang B, Wu Z, Wu S, Jiang G, Wang H, Huang Y
Chemico-biological interactions 2023 Sep 1;382:110607
Chemico-biological interactions 2023 Sep 1;382:110607
A novel pyroptosis-associated lncRNA LINC01133 promotes pancreatic adenocarcinoma development via miR-30b-5p/SIRT1 axis.
Li J, Lin J, Ji Y, Wang X, Fu D, Wang W, Shen B
Cellular oncology (Dordrecht, Netherlands) 2023 Oct;46(5):1381-1398
Cellular oncology (Dordrecht, Netherlands) 2023 Oct;46(5):1381-1398
PM2.5 mediates mouse testis Sertoli TM4 cell damage by reducing cellular NAD().
Xu P, Ren T, Yang Y
Toxicology mechanisms and methods 2023 Oct;33(8):636-645
Toxicology mechanisms and methods 2023 Oct;33(8):636-645
Effects of Gestational Hypoxia on PGC1α and Mitochondrial Acetylation in Fetal Guinea Pig Hearts.
Song H, Thompson LP
Reproductive sciences (Thousand Oaks, Calif.) 2023 Oct;30(10):2996-3009
Reproductive sciences (Thousand Oaks, Calif.) 2023 Oct;30(10):2996-3009
Sirtuin1 Mediates the Protective Effects of Echinacoside against Sepsis-Induced Acute Lung Injury via Regulating the NOX4-Nrf2 Axis.
Xie W, Deng L, Lin M, Huang X, Qian R, Xiong D, Liu W, Tang S
Antioxidants (Basel, Switzerland) 2023 Oct 29;12(11)
Antioxidants (Basel, Switzerland) 2023 Oct 29;12(11)
Dapagliflozin suppress endoplasmic reticulum stress mediated apoptosis of chondrocytes by activating Sirt1.
Liu Z, Huang J, Wang X, Deng S, Zhou J, Gong Z, Li X, Wang Y, Yang J, Hu Y
Chemico-biological interactions 2023 Oct 1;384:110724
Chemico-biological interactions 2023 Oct 1;384:110724
Shuangshi Tonglin capsule improves chronic prostatitis through the SIRT-1/AMPK and MAPK signalling pathways.
Liu Q, Zhang X, Mao P, Wang Z, Mao Q, Wang C, Liu J, Zhu X, Wang B, Wei H
Heliyon 2023 Nov;9(11):e21745
Heliyon 2023 Nov;9(11):e21745
SIRT1-dependent mitochondrial biogenesis supports therapeutic effects of vidarabine against rotenone-induced neural cell injury.
Li L, Zhang Y, Chen Z, Yao R, Xu Z, Xu C, He F, Pei H, Hao C
Heliyon 2023 Nov;9(11):e21695
Heliyon 2023 Nov;9(11):e21695
Miquelianin in Folium Nelumbinis extract promotes white-to-beige fat conversion via blocking AMPK/DRP1/mitophagy and modulating gut microbiota in HFD-fed mice.
Wang Z, Yang T, Zeng M, Wang Z, Chen Q, Chen J, Christian M, He Z
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Nov;181:114089
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Nov;181:114089
SIRT1-dependent mitochondrial biogenesis supports therapeutic effects of 4-butyl-polyhydroxybenzophenone compounds against NAFLD.
Song J, Ren L, Ren Z, Ren X, Qi Y, Qin Y, Zhang X, Ren Y, Li Y
European journal of medicinal chemistry 2023 Nov 15;260:115728
European journal of medicinal chemistry 2023 Nov 15;260:115728
5-(3',4'-dihydroxyphenyl)-γ-valerolactone, a microbiota metabolite of flavan-3-ols, activates SIRT1-mediated autophagy to attenuate H₂O₂-induced inhibition of osteoblast differentiation in MC3T3-E1 cells.
Chen F, Zhang X, Chen S, Wu Y, Wei Q, Chu X, Zhang Z
Free radical biology & medicine 2023 Nov 1;208:309-318
Free radical biology & medicine 2023 Nov 1;208:309-318
Sirt1 protects against intervertebral disc degeneration induced by 1,25-dihydroxyvitamin D insufficiency in mice by inhibiting the NF-κB inflammatory pathway.
Wang P, Yang C, Lu J, Ren Y, Goltzman D, Miao D
Journal of orthopaedic translation 2023 May;40:13-26
Journal of orthopaedic translation 2023 May;40:13-26
Naringin against doxorubicin-induced hepatotoxicity in mice through reducing oxidative stress, inflammation, and apoptosis via the up-regulation of SIRT1.
Xi Y, Chi Z, Tao X, Zhai X, Zhao Z, Ren J, Yang S, Dong D
Environmental toxicology 2023 May;38(5):1153-1161
Environmental toxicology 2023 May;38(5):1153-1161
Resveratrol protects renal damages induced by periodontitis via preventing mitochondrial dysfunction in rats.
Li X, Liu XC, Ding X, Liu XM, Cao NB, Deng Y, Hou YB, Yu WX
Oral diseases 2023 May;29(4):1812-1825
Oral diseases 2023 May;29(4):1812-1825
SZC-6, a small-molecule activator of SIRT3, attenuates cardiac hypertrophy in mice.
Li ZY, Lu GQ, Lu J, Wang PX, Zhang XL, Zou Y, Liu PQ
Acta pharmacologica Sinica 2023 Mar;44(3):546-560
Acta pharmacologica Sinica 2023 Mar;44(3):546-560
The mechanism of low-level arsenic exposure-induced hypertension: Inhibition of the activity of the angiotensin-converting enzyme 2.
Rahaman MS, Mise N, Ikegami A, Zong C, Ichihara G, Ichihara S
Chemosphere 2023 Mar;318:137911
Chemosphere 2023 Mar;318:137911
Resveratrol reversed ambient particulate matter exposure-perturbed oscillations of hepatic glucose metabolism by regulating SIRT1 in mice.
Jiang J, Gu Y, Ding S, Zhang G, Ding J
Environmental science and pollution research international 2023 Mar;30(11):31821-31834
Environmental science and pollution research international 2023 Mar;30(11):31821-31834
Erxian decoction alleviates cisplatin-induced premature ovarian failure in rats by reducing oxidation levels in ovarian granulosa cells.
Liu J, Yang Y, He Y, Feng C, Ou H, Yang J, Chen Y, You F, Shao B, Bao J, Guan X, Chen F, Zhao P
Journal of ethnopharmacology 2023 Mar 25;304:116046
Journal of ethnopharmacology 2023 Mar 25;304:116046
N(6)-methyladenosine of Spi2a attenuates inflammation and sepsis-associated myocardial dysfunction in mice.
Wang X, Ding Y, Li R, Zhang R, Ge X, Gao R, Wang M, Huang Y, Zhang F, Zhao B, Liao W, Du J
Nature communications 2023 Mar 2;14(1):1185
Nature communications 2023 Mar 2;14(1):1185
Phosphoglycerate dehydrogenase activates PKM2 to phosphorylate histone H3T11 and attenuate cellular senescence.
Wu Y, Tang L, Huang H, Yu Q, Hu B, Wang G, Ge F, Yin T, Li S, Yu X
Nature communications 2023 Mar 10;14(1):1323
Nature communications 2023 Mar 10;14(1):1323
Neonatal exposure to low-dose X-ray causes behavioral defects and abnormal hippocampal development in mice.
Liu Y, Ma H, Wang Y, Ren B, Liu L, Sun A, Tang F
IUBMB life 2023 Jun;75(6):530-547
IUBMB life 2023 Jun;75(6):530-547
miR-484 mediates oxidative stress-induced ovarian dysfunction and promotes granulosa cell apoptosis via SESN2 downregulation.
Wang X, Yang J, Li H, Mu H, Zeng L, Cai S, Su P, Li H, Zhang L, Xiang W
Redox biology 2023 Jun;62:102684
Redox biology 2023 Jun;62:102684
METTL3-mediated m6A modification of SIRT1 mRNA inhibits progression of endometriosis by cellular senescence enhancing.
Wang X, Wang J, Zhao X, Wu H, Li J, Cheng Y, Guo Q, Cao X, Liang T, Sun L, Zhang G
Journal of translational medicine 2023 Jun 23;21(1):407
Journal of translational medicine 2023 Jun 23;21(1):407
β-Nicotinamide mononucleotide activates NAD+/SIRT1 pathway and attenuates inflammatory and oxidative responses in the hippocampus regions of septic mice.
Li HR, Liu Q, Zhu CL, Sun XY, Sun CY, Yu CM, Li P, Deng XM, Wang JF
Redox biology 2023 Jul;63:102745
Redox biology 2023 Jul;63:102745
Hydrogen sulfide attenuates TMAO‑induced macrophage inflammation through increased SIRT1 sulfhydration.
Liu MH, Lin XL, Xiao LL
Molecular medicine reports 2023 Jul;28(1)
Molecular medicine reports 2023 Jul;28(1)
Silicate ions as soluble form of bioactive ceramics alleviate aortic aneurysm and dissection.
Que Y, Zhang Z, Zhang Y, Li X, Chen L, Chen P, Ou C, Yang C, Chang J
Bioactive materials 2023 Jul;25:716-731
Bioactive materials 2023 Jul;25:716-731
Astragaloside IV ameliorates cognitive impairment and protects oligodendrocytes from antioxidative stress via regulation of the SIRT1/Nrf2 signaling pathway.
Ma J, Chen T, Wang R
Neurochemistry international 2023 Jul;167:105535
Neurochemistry international 2023 Jul;167:105535
Mulberry leaves attenuate D-galactose-induced aging in vivo and in vitro.
Zhu Y, Han Y, Wang W, Liang G, Qi J
Journal of ethnopharmacology 2023 Jul 15;311:116286
Journal of ethnopharmacology 2023 Jul 15;311:116286
Down-regulated Smyd1 participated in the inhibition of myoblast differentiation induced by cigarette smoke extract.
Li F, Xu M, Miao J, Hu N, Wang Y, Wang L
Toxicology letters 2023 Jul 1;383:98-111
Toxicology letters 2023 Jul 1;383:98-111
Dietary leucine and fish oil cooperatively regulate skeletal myofiber type transformation via the CaMKII signaling pathway of pigs.
Gong S, Yin Y, Han M, Guo L, Duan Y, Guo Q, Yin J, Li F
Food & function 2023 Jan 3;14(1):133-147
Food & function 2023 Jan 3;14(1):133-147
Platelet-derived extracellular vesicles ameliorate intervertebral disc degeneration by alleviating mitochondrial dysfunction.
Dai Z, Xia C, Zhao T, Wang H, Tian H, Xu O, Zhu X, Zhang J, Chen P
Materials today. Bio 2023 Feb;18:100512
Materials today. Bio 2023 Feb;18:100512
Melatonin alleviates BDE-209-induced cognitive impairment and hippocampal neuroinflammation by modulating microglia polarization via SIRT1-mediated HMGB1/TLR4/NF-κB pathway.
Wu J, Hao Z, Wang Y, Yan D, Meng J, Ma H
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Feb;172:113561
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Feb;172:113561
Selenium alleviates cadmium-induced mitophagy through FUNDC1-mediated mitochondrial quality control pathway in the lungs of sheep.
Lin S, Yang F, Hu M, Chen J, Chen G, Hu A, Li X, Fu D, Xing C, Xiong Z, Wu Y, Cao H
Environmental pollution (Barking, Essex : 1987) 2023 Feb 15;319:120954
Environmental pollution (Barking, Essex : 1987) 2023 Feb 15;319:120954
Quercetin alleviates lipopolysaccharide‑induced acute lung injury by inhibiting ferroptosis via the Sirt1/Nrf2/Gpx4 pathway.
Deng S, Li J, Li L, Lin S, Yang Y, Liu T, Zhang T, Xie G, Wu D, Xu Y
International journal of molecular medicine 2023 Dec;52(6)
International journal of molecular medicine 2023 Dec;52(6)
miR-653-3p promotes genomic instability of colorectal cancer cells via targeting SIRT1/TWIST1 signaling pathway.
Wang H, Liang Y, Zhao L, Deng J, Li Y, Zhao H, Zhang X, Zou F
Biochimica et biophysica acta. Molecular basis of disease 2023 Dec;1869(8):166821
Biochimica et biophysica acta. Molecular basis of disease 2023 Dec;1869(8):166821
Decreased SIRT1 mRNA expression in peripheral blood mononuclear cells from patients with neuromyelitis optica spectrum disorders.
Zhang L, Xue Y, Yuan C, Du X, Wang X, Guo L, Li B
Acta neurologica Belgica 2023 Dec;123(6):2287-2294
Acta neurologica Belgica 2023 Dec;123(6):2287-2294
7,8,3'-Trihydroxyflavone prevents doxorubicin-induced cardiotoxicity and mitochondrial dysfunction via activating Akt signaling pathway in H9c2 cells.
Zhao J, Yu HQ, Ge FQ, Zhang MR, Song YC, Guo DD, Li QH, Zhu H, Hang PZ
Cellular signalling 2023 Dec;112:110924
Cellular signalling 2023 Dec;112:110924
Didymin alleviates metabolic dysfunction-associated fatty liver disease (MAFLD) via the stimulation of Sirt1-mediated lipophagy and mitochondrial biogenesis.
Yang JW, Zou Y, Chen J, Cui C, Song J, Yang MM, Gao J, Hu HQ, Xia LQ, Wang LM, Lv XY, Chen L, Hou XG
Journal of translational medicine 2023 Dec 19;21(1):921
Journal of translational medicine 2023 Dec 19;21(1):921
Resveratrol Improves the Frozen-Thawed Ram Sperm Quality.
Zhu Z, Zhao H, Cui H, Adetunji AO, Min L
Animals : an open access journal from MDPI 2023 Dec 18;13(24)
Animals : an open access journal from MDPI 2023 Dec 18;13(24)
Paeoniflorin recued hepatotoxicity under zinc oxide nanoparticles exposure via regulation on gut-liver axis and reversal of pyroptosis.
Pei X, Tang S, Jiang H, Zhang W, Xu G, Zuo Z, Ren Z, Chen C, Shen Y, Li C, Li D
The Science of the total environment 2023 Dec 15;904:166885
The Science of the total environment 2023 Dec 15;904:166885
Polystyrene exacerbates cadmium-induced mitochondrial damage to lung by blocking autophagy in mice.
Tong X, Fu X, Yu G, Qu H, Zou H, Song R, Ma Y, Yuan Y, Bian J, Gu J, Liu Z
Environmental toxicology 2023 Aug;38(8):1775-1785
Environmental toxicology 2023 Aug;38(8):1775-1785
Exogenous hydrogen sulfide alleviates hepatic endoplasmic reticulum stress via SIRT1/FoxO1/PCSK9 pathway in NAFLD.
Cui X, Yao M, Feng Y, Li C, Li Y, Guo D, He S
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Aug;37(8):e23027
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Aug;37(8):e23027
Tanshinone IIA ameliorates experimental diabetic cardiomyopathy by inhibiting endoplasmic reticulum stress in cardiomyocytes via SIRT1.
Wu S, Lu D, Gajendran B, Hu Q, Zhang J, Wang S, Han M, Xu Y, Shen X
Phytotherapy research : PTR 2023 Aug;37(8):3543-3558
Phytotherapy research : PTR 2023 Aug;37(8):3543-3558
Inhibition of SIRT1 promotes ultraviolet B induced cataract via downregulation of the KEAP1/NFE2L2 signaling pathway.
Wu F, Xia X, Lei T, Du H, Hua H, Liu W, Xu B, Yang T
Journal of photochemistry and photobiology. B, Biology 2023 Aug;245:112753
Journal of photochemistry and photobiology. B, Biology 2023 Aug;245:112753
Salidroside alleviates oxidative stress in dry eye disease by activating autophagy through AMPK-Sirt1 pathway.
Liang Q, Guo R, Tsao JR, He Y, Wang C, Jiang J, Zhang D, Chen T, Yue T, Hu K
International immunopharmacology 2023 Aug;121:110397
International immunopharmacology 2023 Aug;121:110397
Salidroside ameliorates acetaminophen-induced acute liver injury through the inhibition of endoplasmic reticulum stress-mediated ferroptosis by activating the AMPK/SIRT1 pathway.
Xu J, Zhao L, Zhang X, Ying K, Zhou R, Cai W, Wu X, Jiang H, Xu Q, Miao D, Zeng Y, Yu F
Ecotoxicology and environmental safety 2023 Aug 7;262:115331
Ecotoxicology and environmental safety 2023 Aug 7;262:115331
Salidroside alleviates acetaminophen-induced hepatotoxicity via Sirt1-mediated activation of Akt/Nrf2 pathway and suppression of NF-κB/NLRP3 inflammasome axis.
Gao Z, Zhan H, Zong W, Sun M, Linghu L, Wang G, Meng F, Chen M
Life sciences 2023 Aug 15;327:121793
Life sciences 2023 Aug 15;327:121793
Intermittent fasting activates macrophage migration inhibitory factor and alleviates high-fat diet-induced nonalcoholic fatty liver disease.
Li D, Dun Y, Qi D, Ripley-Gonzalez JW, Dong J, Zhou N, Qiu L, Zhang J, Zeng T, You B, Liu S
Scientific reports 2023 Aug 11;13(1):13068
Scientific reports 2023 Aug 11;13(1):13068
Astaxanthin promotes mitochondrial biogenesis and antioxidant capacity in chronic high-intensity interval training.
Wang Y, Chen X, Baker JS, Davison GW, Xu S, Zhou Y, Bao X
European journal of nutrition 2023 Apr;62(3):1453-1466
European journal of nutrition 2023 Apr;62(3):1453-1466
MiR-155 promotes inflammation and apoptosis via targeting SIRT1 in hypoxic-ischemic brain damage.
Ke F, Wang H, Geng J, Jing X, Fang F, Fang C, Zhang BH
Experimental neurology 2023 Apr;362:114317
Experimental neurology 2023 Apr;362:114317
Syndecan-3 Coregulates Milk Fat Metabolism and Inflammatory Reactions in Bovine Mammary Epithelial Cells through AMPK/SIRT1 Signaling Pathway.
Fan J, Zhao Z, Wu H, Fang X, Miao F, Chen X, Jiang X, Li J, Jiang P, Yu H
International journal of molecular sciences 2023 Apr 3;24(7)
International journal of molecular sciences 2023 Apr 3;24(7)
Salvianolic Acid A Protects against Acetaminophen-Induced Hepatotoxicity via Regulation of the miR-485-3p/SIRT1 Pathway.
Tang F, Wang Z, Zhou J, Yao J
Antioxidants (Basel, Switzerland) 2023 Apr 3;12(4)
Antioxidants (Basel, Switzerland) 2023 Apr 3;12(4)
Nuclear ATR lysine-tyrosylation protects against heart failure by activating DNA damage response.
Zhao R, Cai K, Yang JJ, Zhou Q, Cao W, Xiang J, Shen YH, Cheng LL, Zang WD, Lin Y, Yuan YY, Xu W, Tao H, Zhao SM, Zhao JY
Cell reports 2023 Apr 25;42(4):112400
Cell reports 2023 Apr 25;42(4):112400
High-Dosage NMN Promotes Ferroptosis to Suppress Lung Adenocarcinoma Growth through the NAM-Mediated SIRT1-AMPK-ACC Pathway.
Zhang M, Cui J, Chen H, Wang Y, Kuai X, Sun S, Tang Q, Zong F, Chen Q, Wu J, Wu S
Cancers 2023 Apr 23;15(9)
Cancers 2023 Apr 23;15(9)
Gandi Capsule Improved Podocyte Lipid Metabolism of Diabetic Nephropathy Mice through SIRT1/AMPK/HNF4A Pathway.
Zhang Y, Yao H, Li C, Sun W, Chen X, Cao Y, Liu Y, Liu Y, Chen J, Qi J, Zhang Q, Zhang H, Xu A, Zhang J
Oxidative medicine and cellular longevity 2022;2022:6275505
Oxidative medicine and cellular longevity 2022;2022:6275505
Catalpol Enhances Random-Pattern Skin Flap Survival by Activating SIRT1-Mediated Enhancement of Autophagy.
Jiang RH, Dong CJ, Chen ZL, Cheng S, Yang JX, Gao WY
Oxidative medicine and cellular longevity 2022;2022:5668226
Oxidative medicine and cellular longevity 2022;2022:5668226
Fluorofenidone Inhibits UUO/IRI-Induced Renal Fibrosis by Reducing Mitochondrial Damage.
Liao X, Lv X, Zhang Y, Han Y, Li J, Zeng J, Tang D, Meng J, Yuan X, Peng Z, Tao L, Xie Y
Oxidative medicine and cellular longevity 2022;2022:2453617
Oxidative medicine and cellular longevity 2022;2022:2453617
Electroacupuncture Pretreatment Exhibits Lung Protective and Anti-Inflammation Effects in Lipopolysaccharide-Induced Acute Lung Injury via SIRT1-Dependent Pathways.
Luo D, Liu L, Zhang HM, Zhou YD, Zhou MF, Li JX, Yu ZM, Tang Q, Yang SR, Chen R, Liang FX
Evidence-based complementary and alternative medicine : eCAM 2022;2022:2252218
Evidence-based complementary and alternative medicine : eCAM 2022;2022:2252218
∆nFGF1 Protects β-Cells against High Glucose-Induced Apoptosis via the AMPK/SIRT1/PGC-1α Axis.
Chen Q, Chen X, Jia Z, Du Y, Zhang S, Xu W, Pan B, Lou J, Zhou J, Zhou J, Sun J
Oxidative medicine and cellular longevity 2022;2022:1231970
Oxidative medicine and cellular longevity 2022;2022:1231970
Atractylenolide III ameliorates Non-Alcoholic Fatty Liver Disease by activating Hepatic Adiponectin Receptor 1-Mediated AMPK Pathway.
Li Q, Tan JX, He Y, Bai F, Li SW, Hou YW, Ji LS, Gao YT, Zhang X, Zhou ZH, Yu Z, Fang M, Gao YQ, Li M
International journal of biological sciences 2022;18(4):1594-1611
International journal of biological sciences 2022;18(4):1594-1611
Photobiomodulation promotes repair following spinal cord injury by restoring neuronal mitochondrial bioenergetics via AMPK/PGC-1α/TFAM pathway.
Zhu Z, Wang X, Song Z, Zuo X, Ma Y, Zhang Z, Ju C, Liang Z, Li K, Hu X, Wang Z
Frontiers in pharmacology 2022;13:991421
Frontiers in pharmacology 2022;13:991421
Melatonin promotes sirtuin 1 expression and inhibits IRE1α-XBP1S-CHOP to reduce endoplasmic reticulum stress-mediated apoptosis in chondrocytes.
Qin K, Tang H, Ren Y, Yang D, Li Y, Huang W, Wu Y, Yin Z
Frontiers in pharmacology 2022;13:940629
Frontiers in pharmacology 2022;13:940629
Protective effect of Astragaloside IV on chronic intermittent hypoxia-induced vascular endothelial dysfunction through the calpain-1/SIRT1/AMPK signaling pathway.
Zhao F, Meng Y, Wang Y, Fan S, Liu Y, Zhang X, Ran C, Wang H, Lu M
Frontiers in pharmacology 2022;13:920977
Frontiers in pharmacology 2022;13:920977
Chitosan/Sodium Alginate/Velvet Antler Blood Peptides Hydrogel Promoted Wound Healing by Regulating PI3K/AKT/mTOR and SIRT1/NF-κB Pathways.
Hao M, Peng X, Sun S, Ding C, Liu W
Frontiers in pharmacology 2022;13:913408
Frontiers in pharmacology 2022;13:913408
Antisense Oligonucleotide-Based Therapy on miR-181a-5p Alleviates Cartilage Degradation of Temporomandibular Joint Osteoarthritis via Promoting SIRT1.
Qi H, Zhao Z, Xu L, Zhang Y, Li Y, Xiao L, Li Y, Zhao Z, Fang J
Frontiers in pharmacology 2022;13:898334
Frontiers in pharmacology 2022;13:898334
Sleeve Gastrectomy-Induced AMPK Activation Attenuates Diabetic Cardiomyopathy by Maintaining Mitochondrial Homeostasis via NR4A1 Suppression in Rats.
Li S, Dong S, Xu Q, Shi B, Li L, Zhang W, Zhu J, Cheng Y, Zhang G, Zhong M
Frontiers in physiology 2022;13:837798
Frontiers in physiology 2022;13:837798
Cold Exposure Induces Intestinal Barrier Damage and Endoplasmic Reticulum Stress in the Colon via the SIRT1/Nrf2 Signaling Pathway.
Guo J, Hu H, Chen Z, Xu J, Nie J, Lu J, Ma L, Ji H, Yuan J, Xu B
Frontiers in physiology 2022;13:822348
Frontiers in physiology 2022;13:822348
Involvement of the SIRT1/PGC-1α Signaling Pathway in Noise-Induced Hidden Hearing Loss.
Liu YH, Jiang YH, Li CC, Chen XM, Huang LG, Zhang M, Ruan B, Wang XC
Frontiers in physiology 2022;13:798395
Frontiers in physiology 2022;13:798395
Mouse promyelocytic leukemia zinc finger protein (PLZF) regulates hepatic lipid and glucose homeostasis dependent on SIRT1.
Hu H, Sun N, Du H, He Y, Pan K, Liu X, Lu X, Wei J, Liao M, Duan C
Frontiers in pharmacology 2022;13:1039726
Frontiers in pharmacology 2022;13:1039726
Yinchen Linggui Zhugan decoction ameliorates high fat diet-induced nonalcoholic fatty liver disease by modulation of SIRT1/Nrf2 signaling pathway and gut microbiota.
Jiang H, Mao T, Sun Z, Shi L, Han X, Zhang Y, Zhang X, Wang J, Hu J, Zhang L, Li J, Han H
Frontiers in microbiology 2022;13:1001778
Frontiers in microbiology 2022;13:1001778
Small extracellular vesicle-associated miR-6068 promotes aggressive phenotypes of prostate cancer through miR-6068/HIC2/SIRT1 axis.
Gaballah MSA, Ali HEA, Hassan ZA, Mahgoub S, Ali HI, Rhim JS, Zerfaoui M, El Sayed KA, Stephen D, Sylvester PW, Abd Elmageed ZY
American journal of cancer research 2022;12(8):4015-4027
American journal of cancer research 2022;12(8):4015-4027
Naringenin regulates gut microbiota and SIRT1/ PGC-1ɑ signaling pathway in rats with letrozole-induced polycystic ovary syndrome.
Wu YX, Yang XY, Han BS, Hu YY, An T, Lv BH, Lian J, Wang TY, Bao XL, Gao L, Jiang GJ
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Sep;153:113286
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Sep;153:113286
Glutamine in suppression of lipopolysaccharide-induced piglet intestinal inflammation: The crosstalk between AMPK activation and mitochondrial function.
He L, Zhou X, Wu Z, Feng Y, Liu D, Li T, Yin Y
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2022 Sep;10:137-147
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2022 Sep;10:137-147
SUMOylation of SIRT1 activating PGC-1α/PPARα pathway mediates the protective effect of LncRNA-MHRT in cardiac hypertrophy.
Liu MY, Yue LJ, Luo YC, Lu J, Wu GD, Sheng SQ, Shi YQ, Dong ZX
European journal of pharmacology 2022 Sep 5;930:175155
European journal of pharmacology 2022 Sep 5;930:175155
SIRT1 modifies DNA methylation linked to synaptic deficits induced by Pb in vitro and in vivo.
Wang R, Yang M, Wu Y, Liu R, Liu M, Li Q, Su X, Xin Y, Huo W, Deng Q, Ba Y, Huang H
International journal of biological macromolecules 2022 Sep 30;217:219-228
International journal of biological macromolecules 2022 Sep 30;217:219-228
Yangjing Zhongyu decoction facilitates mitochondrial activity, estrogenesis, and energy metabolism in H(2)O(2)-induced human granulosa cell line KGN.
Liu J, Shi D, Ma Q, Zhao P
Journal of ethnopharmacology 2022 Sep 15;295:115398
Journal of ethnopharmacology 2022 Sep 15;295:115398
Anti-inflammatory potential of stevia residue extract against uric acid-associated renal injury in mice.
Mehmood A, Althobaiti F, Zhao L, Usman M, Chen X, Alharthi F, Soliman MM, Shah AA, Murtaza MA, Nadeem M, Ranjha MMAN, Wang C
Journal of food biochemistry 2022 Oct;46(10):e14286
Journal of food biochemistry 2022 Oct;46(10):e14286
Angiotensin II type-2 receptor activation in alveolar macrophages mediates protection against cigarette smoke-induced chronic obstructive pulmonary disease.
Mei D, Liao W, Gan PXL, Tran QTN, Chan CCMY, Heng CKM, Wong WSF
Pharmacological research 2022 Oct;184:106469
Pharmacological research 2022 Oct;184:106469
Ginseng under forest exerts stronger anti-aging effects compared to garden ginseng probably via regulating PI3K/AKT/mTOR pathway, SIRT1/NF-κB pathway and intestinal flora.
Hao M, Ding C, Peng X, Chen H, Dong L, Zhang Y, Chen X, Liu W, Luo Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Oct;105:154365
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Oct;105:154365
Transcriptomic Analysis Reveals Lactobacillus reuteri Alleviating Alcohol-Induced Liver Injury in Mice by Enhancing the Farnesoid X Receptor Signaling Pathway.
Cheng Y, Xiang X, Liu C, Cai T, Li T, Chen Y, Bai J, Shi H, Zheng T, Huang M, Fu W
Journal of agricultural and food chemistry 2022 Oct 5;70(39):12550-12564
Journal of agricultural and food chemistry 2022 Oct 5;70(39):12550-12564
Recombinant Humanized IgG1 Antibody Protects against oxLDL-Induced Oxidative Stress and Apoptosis in Human Monocyte/Macrophage THP-1 Cells by Upregulation of MSRA via Sirt1-FOXO1 Axis.
Zhang Q, Li Z, Liu X, Zhao M
International journal of molecular sciences 2022 Oct 3;23(19)
International journal of molecular sciences 2022 Oct 3;23(19)
METTL3 acetylation impedes cancer metastasis via fine-tuning its nuclear and cytosolic functions.
Li Y, He X, Lu X, Gong Z, Li Q, Zhang L, Yang R, Wu C, Huang J, Ding J, He Y, Liu W, Chen C, Cao B, Zhou D, Shi Y, Chen J, Wang C, Zhang S, Zhang J, Ye J, You H
Nature communications 2022 Oct 26;13(1):6350
Nature communications 2022 Oct 26;13(1):6350
Disturbing NLRP3 acetylation and inflammasome assembly inhibits androgen receptor-promoted inflammatory responses and prostate cancer progression.
Zhao AN, Yang Z, Wang DD, Shi B, Zhang H, Bai Y, Yan BW, Zhang Y, Wen JK, Wang XL, Qu CB
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Nov;36(11):e22602
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Nov;36(11):e22602
Hyperglycemia promotes myocardial dysfunction via the ERS-MAPK10 signaling pathway in db/db mice.
Deng YW, Liu F, Li ZT, Gao JH, Zhao Y, Yang XL, Xia YL
Laboratory investigation; a journal of technical methods and pathology 2022 Nov;102(11):1192-1202
Laboratory investigation; a journal of technical methods and pathology 2022 Nov;102(11):1192-1202
SIRT2 promotes the viability, invasion and metastasis of osteosarcoma cells by inhibiting the degradation of Snail.
Tian Y, Liu R, Hou X, Gao Z, Liu X, Zhang W
Cell death & disease 2022 Nov 7;13(11):935
Cell death & disease 2022 Nov 7;13(11):935
O-GlcNAcylation of SIRT1 Protects against Cold Stress-Induced Skeletal Muscle Damage via Amelioration of Mitochondrial Homeostasis.
Cao Y, Zhang M, Li Y, Lu J, Zhou W, Li X, Shi H, Xu B, Li S
International journal of molecular sciences 2022 Nov 22;23(23)
International journal of molecular sciences 2022 Nov 22;23(23)
A High-Fat Diet Induces Muscle Mitochondrial Dysfunction and Impairs Swimming Capacity in Zebrafish: A New Model of Sarcopenic Obesity.
Zou YY, Chen ZL, Sun CC, Yang D, Zhou ZQ, Xiao Q, Peng XY, Tang CF
Nutrients 2022 May 9;14(9)
Nutrients 2022 May 9;14(9)
Aberrant methylmalonylation underlies methylmalonic acidemia and is attenuated by an engineered sirtuin.
Head PE, Myung S, Chen Y, Schneller JL, Wang C, Duncan N, Hoffman P, Chang D, Gebremariam A, Gucek M, Manoli I, Venditti CP
Science translational medicine 2022 May 25;14(646):eabn4772
Science translational medicine 2022 May 25;14(646):eabn4772
SIRT1 prevents cigarette smoking-induced lung fibroblasts activation by regulating mitochondrial oxidative stress and lipid metabolism.
Zhang Y, Li T, Pan M, Wang W, Huang W, Yuan Y, Xie Z, Chen Y, Peng J, Li X, Meng Y
Journal of translational medicine 2022 May 14;20(1):222
Journal of translational medicine 2022 May 14;20(1):222
Circular RNA PVT1 inhibits tendon stem/progenitor cell senescence by sponging microRNA-199a-5p.
Han W, Tao X, Weng T, Chen L
Toxicology in vitro : an international journal published in association with BIBRA 2022 Mar;79:105297
Toxicology in vitro : an international journal published in association with BIBRA 2022 Mar;79:105297
Polysaccharides from Platycodonis Radix ameliorated respiratory syncytial virus-induced epithelial cell apoptosis and inflammation through activation of miR-181a-mediated Hippo and SIRT1 pathways.
Li JJ, Liu ML, Lv JN, Chen RL, Ding K, He JQ
International immunopharmacology 2022 Mar;104:108510
International immunopharmacology 2022 Mar;104:108510
Polydatin Attenuates Intra-Uterine Growth Retardation-Induced Liver Injury and Mitochondrial Dysfunction in Weanling Piglets by Improving Energy Metabolism and Redox Balance.
Chen Y, Li Y, Jia P, Ji S, Zhang H, Wang T
Antioxidants (Basel, Switzerland) 2022 Mar 30;11(4)
Antioxidants (Basel, Switzerland) 2022 Mar 30;11(4)
Modification of lysine deacetylation regulates curcumol-induced necroptosis through autophagy in hepatic stellate cells.
Sun S, Li Z, Huan S, Kai J, Xia S, Su Y, Ji S, Chen A, Wang S, Xu X, Shao J, Zhang F, Zhang B, Zhang Z, Zheng S
Phytotherapy research : PTR 2022 Jun;36(6):2660-2676
Phytotherapy research : PTR 2022 Jun;36(6):2660-2676
SIRT1 alleviates IL-1β induced nucleus pulposus cells pyroptosis via mitophagy in intervertebral disc degeneration.
Ma Z, Tang P, Dong W, Lu Y, Tan B, Zhou N, Hao J, Shen J, Hu Z
International immunopharmacology 2022 Jun;107:108671
International immunopharmacology 2022 Jun;107:108671
Estradiol initiates the immune escape of non-small cell lung cancer cells via ERβ/SIRT1/FOXO3a/PD-L1 axis.
Song S, Tang H, Quan W, Shang A, Ling C
International immunopharmacology 2022 Jun;107:108629
International immunopharmacology 2022 Jun;107:108629
Sirt1 protects against hippocampal atrophy and its induced cognitive impairment in middle-aged mice.
Sun Z, Zhao S, Suo X, Dou Y
BMC neuroscience 2022 Jun 6;23(1):33
BMC neuroscience 2022 Jun 6;23(1):33
Integrated metabolism and epigenetic modifications in the macrophages of mice in responses to cold stress.
Lu J, Fu S, Dai J, Hu J, Li S, Ji H, Wang Z, Yu J, Bao J, Xu B, Guo J, Yang H
Journal of Zhejiang University. Science. B 2022 Jun 15;23(6):461-480
Journal of Zhejiang University. Science. B 2022 Jun 15;23(6):461-480
Inhibition of nuclear deacetylase Sirtuin-1 induces mitochondrial acetylation and calcium overload leading to cell death.
Sun Y, Yang YM, Hu YY, Ouyang L, Sun ZH, Yin XF, Li N, He QY, Wang Y
Redox biology 2022 Jul;53:102334
Redox biology 2022 Jul;53:102334
MG53 protein rejuvenates hUC-MSCs and facilitates their therapeutic effects in AD mice by activating Nrf2 signaling pathway.
Ma S, Zhou X, Wang Y, Li Z, Wang Y, Shi J, Guan F
Redox biology 2022 Jul;53:102325
Redox biology 2022 Jul;53:102325
Selenium alleviates cadmium-induced aging via mitochondrial quality control in the livers of sheep.
Xiong Z, Yang F, Xu T, Yang Y, Wang F, Zhou G, Wang Q, Guo X, Xing C, Bai H, Chen J, Wu Y, Yang S, Cao H
Journal of inorganic biochemistry 2022 Jul;232:111818
Journal of inorganic biochemistry 2022 Jul;232:111818
Phenylalanine impairs insulin signaling and inhibits glucose uptake through modification of IRβ.
Zhou Q, Sun WW, Chen JC, Zhang HL, Liu J, Lin Y, Lin PC, Wu BX, An YP, Huang L, Sun WX, Zhou XW, Li YM, Yuan YY, Zhao JY, Xu W, Zhao SM
Nature communications 2022 Jul 25;13(1):4291
Nature communications 2022 Jul 25;13(1):4291
Effect of Qingyangshen glycosides on social defeat mice model.
Liu D, Wang J, Chang L, Zhu Q, Jiang N, Azhar M, Zeng G
Journal of ethnopharmacology 2022 Jul 15;293:115253
Journal of ethnopharmacology 2022 Jul 15;293:115253
NAD(P)H: quinone oxidoreductase 1 attenuates oxidative stress and apoptosis by regulating Sirt1 in diabetic nephropathy.
Qiu D, Song S, Wang Y, Bian Y, Wu M, Wu H, Shi Y, Duan H
Journal of translational medicine 2022 Jan 28;20(1):44
Journal of translational medicine 2022 Jan 28;20(1):44
Iron overload inhibits cell proliferation and promotes autophagy via PARP1/SIRT1 signaling in endometriosis and adenomyosis.
Zhou Y, Zhao X, Zhang L, Xia Q, Peng Y, Zhang H, Yan D, Yang Z, Li J
Toxicology 2022 Jan 15;465:153050
Toxicology 2022 Jan 15;465:153050
Ubiquitin-specific protease 3 attenuates interleukin-1β-mediated chondrocyte senescence by deacetylating forkhead box O-3 via sirtuin-3.
Zhou Q, Wang W, Wu J, Qiu S, Yuan S, Fu PL, Qian QR, Xu YZ
Bioengineered 2022 Feb;13(2):2017-2027
Bioengineered 2022 Feb;13(2):2017-2027
Ginsenoside CK ameliorates hepatic lipid accumulation via activating the LKB1/AMPK pathway in vitro and in vivo.
Zhang J, Ma X, Fan D
Food & function 2022 Feb 7;13(3):1153-1167
Food & function 2022 Feb 7;13(3):1153-1167
A plant-derived natural photosynthetic system for improving cell anabolism.
Chen P, Liu X, Gu C, Zhong P, Song N, Li M, Dai Z, Fang X, Liu Z, Zhang J, Tang R, Fan S, Lin X
Nature 2022 Dec;612(7940):546-554
Nature 2022 Dec;612(7940):546-554
Small ubiquitin-related modifier (SUMO)ylation of SIRT1 mediates (-)-epicatechin inhibited- differentiation of cardiac fibroblasts into myofibroblasts.
Luo Y, Lu J, Wang Z, Wang L, Wu G, Guo Y, Dong Z
Pharmaceutical biology 2022 Dec;60(1):1762-1770
Pharmaceutical biology 2022 Dec;60(1):1762-1770
Nicotinamide mononucleotide promotes pancreatic islet function through the SIRT1 pathway in mice after severe burns.
Liu X, Li D, Liu Z, Song Y, Zhang B, Zang Y, Zhang W, Niu Y, Shen C
Burns : journal of the International Society for Burn Injuries 2022 Dec;48(8):1922-1932
Burns : journal of the International Society for Burn Injuries 2022 Dec;48(8):1922-1932
Resveratrol inhibits the progression of premature senescence partially by regulating v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA) and sirtuin 1 (SIRT1).
He S, Zhou M, Zheng H, Wang Y, Wu S, Gao Y, Chen J
Renal failure 2022 Dec;44(1):171-183
Renal failure 2022 Dec;44(1):171-183
Epigallocatechin-3-gallate (EGCG) attenuates inflammatory responses and oxidative stress in lipopolysaccharide (LPS)-induced endometritis via silent information regulator transcript-1 (SIRT1)/nucleotide oligomerization domain (NOD)-like receptor pyrin domain-containing 3 (NLRP3) pathway.
Di M, Zhang Q, Wang J, Xiao X, Huang J, Ma Y, Yang H, Li M
Journal of biochemical and molecular toxicology 2022 Dec;36(12):e23203
Journal of biochemical and molecular toxicology 2022 Dec;36(12):e23203
Spermidine Alleviates Intrauterine Hypoxia-Induced Offspring Newborn Myocardial Mitochondrial Damage in Rats by Inhibiting Oxidative Stress and Regulating Mitochondrial Quality Control.
Chai N, Zheng H, Zhang H, Li L, Yu X, Wang L, Bi X, Yang L, Niu T, Liu X, Zhao Y, Dong L
Iranian journal of pharmaceutical research : IJPR 2022 Dec;21(1):e133776
Iranian journal of pharmaceutical research : IJPR 2022 Dec;21(1):e133776
Quercetin protects against LPS-induced lung injury in mice via SIRT1-mediated suppression of PKM2 nuclear accumulation.
Chen LL, Song C, Zhang Y, Li Y, Zhao YH, Lin FY, Han DD, Dai MH, Li W, Pan PH
European journal of pharmacology 2022 Dec 5;936:175352
European journal of pharmacology 2022 Dec 5;936:175352
Cordycepin exhibits anti-fatigue effect via activating TIGAR/SIRT1/PGC-1α signaling pathway.
Chai X, Pan M, Wang J, Feng M, Wang Y, Zhang Q, Sun Y
Biochemical and biophysical research communications 2022 Dec 31;637:127-135
Biochemical and biophysical research communications 2022 Dec 31;637:127-135
Response of the Sirtuin/PXR signaling pathway in Mugilogobius chulae exposed to environmentally relevant concentration Paracetamol.
Meinan X, Yimeng W, Chao W, Tianli T, Li J, Peng Y, Xiangping N
Aquatic toxicology (Amsterdam, Netherlands) 2022 Aug;249:106222
Aquatic toxicology (Amsterdam, Netherlands) 2022 Aug;249:106222
Styrylpyrones from Phellinus linteus Mycelia Alleviate Non-Alcoholic Fatty Liver by Modulating Lipid and Glucose Metabolic Homeostasis in High-Fat and High-Fructose Diet-Fed Mice.
Chiu CH, Chang CC, Lin JJ, Chen CC, Chyau CC, Peng RY
Antioxidants (Basel, Switzerland) 2022 Apr 30;11(5)
Antioxidants (Basel, Switzerland) 2022 Apr 30;11(5)
Deficiency of Sirtuin 1 Impedes Endometrial Decidualization in Recurrent Implantation Failure Patients.
Li J, Qi J, Yao G, Zhu Q, Li X, Xu R, Zhu Z, Zhao H, Wang Y, Ding Y, Sun Y
Frontiers in cell and developmental biology 2021;9:598364
Frontiers in cell and developmental biology 2021;9:598364
Sustained Release of MiR-217 Inhibitor by Nanoparticles Facilitates MSC-Mediated Attenuation of Neointimal Hyperplasia After Vascular Injury.
Yu H, Hua Y, He Y, Wang Y, Hu X, Chen S, Liu J, Yang J, Li H
Frontiers in cardiovascular medicine 2021;8:739107
Frontiers in cardiovascular medicine 2021;8:739107
Exploring the Oxidative Stress Mechanism of Buyang Huanwu Decoction in Intervention of Vascular Dementia Based on Systems Biology Strategy.
Yang K, Zeng L, Ge A, Yi Y, Wang S, Ge J
Oxidative medicine and cellular longevity 2021;2021:8879060
Oxidative medicine and cellular longevity 2021;2021:8879060
l-Theanine Ameliorates d-Galactose-Induced Brain Damage in Rats via Inhibiting AGE Formation and Regulating Sirtuin1 and BDNF Signaling Pathways.
Zeng L, Lin L, Chen L, Xiao W, Gong Z
Oxidative medicine and cellular longevity 2021;2021:8850112
Oxidative medicine and cellular longevity 2021;2021:8850112
Protective Effects of Huangqi Shengmai Yin on Type 1 Diabetes-Induced Cardiomyopathy by Improving Myocardial Lipid Metabolism.
Cao Z, Pan J, Sui X, Fang C, Li N, Huang X, Qu X, Han D
Evidence-based complementary and alternative medicine : eCAM 2021;2021:5590623
Evidence-based complementary and alternative medicine : eCAM 2021;2021:5590623
Protective Effects of N(1)-Methylnicotinamide Against High-Fat Diet- and Age-Induced Hearing Loss via Moderate Overexpression of Sirtuin 1 Protein.
Miwa T
Frontiers in cellular neuroscience 2021;15:634868
Frontiers in cellular neuroscience 2021;15:634868
Ulinastatin protects against acetaminophen-induced liver injury by alleviating ferroptosis via the SIRT1/NRF2/HO-1 pathway.
Wang C, Liu T, Tong Y, Cui R, Qu K, Liu C, Zhang J
American journal of translational research 2021;13(6):6031-6042
American journal of translational research 2021;13(6):6031-6042
Protective Effects and Mechanisms of Polyethylene Glycol Loxenatide Against Hyperglycemia and Liver Injury in db/db diabetic Mice.
Zhang Y, Li Y, Zhao J, Wang C, Deng B, Zhang Q, Shi C
Frontiers in pharmacology 2021;12:781856
Frontiers in pharmacology 2021;12:781856
β-hydroxybutyrate Alleviates Learning and Memory Impairment Through the SIRT1 Pathway in D-Galactose-Injured Mice.
Yang X, Wang R, Zhou H, Wang L, Wang R, Li H, Tan B, Wu Q, Xu X, Cui L, Li Z, Li H
Frontiers in pharmacology 2021;12:751028
Frontiers in pharmacology 2021;12:751028
Impaired Nicotinamide Adenine Dinucleotide Biosynthesis in the Kidney of Chronic Kidney Disease.
Liu X, Luo D, Huang S, Liu S, Zhang B, Wang F, Lu J, Chen J, Li S
Frontiers in physiology 2021;12:723690
Frontiers in physiology 2021;12:723690
Dexmedetomidine Protects Against Septic Liver Injury by Enhancing Autophagy Through Activation of the AMPK/SIRT1 Signaling Pathway.
Yu Q, Zou L, Yuan X, Fang F, Xu F
Frontiers in pharmacology 2021;12:658677
Frontiers in pharmacology 2021;12:658677
S100A11 Promotes Liver Steatosis via FOXO1-Mediated Autophagy and Lipogenesis.
Zhang L, Zhang Z, Li C, Zhu T, Gao J, Zhou H, Zheng Y, Chang Q, Wang M, Wu J, Ran L, Wu Y, Miao H, Zou X, Liang B
Cellular and molecular gastroenterology and hepatology 2021;11(3):697-724
Cellular and molecular gastroenterology and hepatology 2021;11(3):697-724
Exercise training ameliorates early diabetic kidney injury by regulating the H(2) S/SIRT1/p53 pathway.
Yang L, Li DX, Cao BQ, Liu SJ, Xu DH, Zhu XY, Liu YJ
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Sep;35(9):e21823
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Sep;35(9):e21823
The effects of compound centella formula on OxInflammation and silent information regulator 1 in a high-fat diet/streptozotocin-induced diabetic kidney disease rat model.
Zhu Q, Li XH, Chen HY, Jin QY
Experimental and therapeutic medicine 2021 Sep;22(3):962
Experimental and therapeutic medicine 2021 Sep;22(3):962
Loss of Elp1 perturbs histone H2A.Z and the Notch signaling pathway.
Cameron B, Lehrmann E, Chih T, Walters J, Buksch R, Snyder S, Goffena J, Lefcort F, Becker KG, George L
Biology open 2021 Sep 15;10(9)
Biology open 2021 Sep 15;10(9)
miR-132-3p promotes the cisplatin-induced apoptosis and inflammatory response of renal tubular epithelial cells by targeting SIRT1 via the NF-κB pathway.
Han S, Lin F, Ruan Y, Zhao S, Yuan R, Ning J, Jiang K, Xie J, Li H, Li C, Rao T, Yu W, Xia Y, Zhou X, Cheng F
International immunopharmacology 2021 Oct;99:108022
International immunopharmacology 2021 Oct;99:108022
Advanced Maternal Age-associated SIRT1 Deficiency Compromises Trophoblast Epithelial-Mesenchymal Transition through an Increase in Vimentin Acetylation.
Xiong L, Ye X, Chen Z, Fu H, Li S, Xu P, Yu J, Wen L, Gao R, Fu Y, Qi H, Kilby MD, Saffery R, Baker PN, Tong C
Aging cell 2021 Oct;20(10):e13491
Aging cell 2021 Oct;20(10):e13491
Influence of psychostimulants and opioids on epigenetic modification of class III histone deacetylase (HDAC)-sirtuins in glial cells.
Sivalingam K, Doke M, Khan MA, Samikkannu T
Scientific reports 2021 Oct 29;11(1):21335
Scientific reports 2021 Oct 29;11(1):21335
Exercise Intervention Mitigates Pathological Liver Changes in NAFLD Zebrafish by Activating SIRT1/AMPK/NRF2 Signaling.
Zou Y, Chen Z, Sun C, Yang D, Zhou Z, Peng X, Zheng L, Tang C
International journal of molecular sciences 2021 Oct 10;22(20)
International journal of molecular sciences 2021 Oct 10;22(20)
Melatonin alleviated oxidative stress induced by energy restriction on sheep Leydig cells through Sirt1/Sod2 pathway.
Ma J, Yang H, Liu L, Wan Y, Wang F
Theriogenology 2021 Oct 1;173:83-92
Theriogenology 2021 Oct 1;173:83-92
Hepatic COX-2 expression protects mice from an alcohol-high fat diet-induced metabolic disorder by involving protein acetylation related energy metabolism.
Chen M, Sun X, Wei W, Cucarella C, Martín-Sanz P, Casado M, Pi L, Ren B, Cao Q
Alcohol (Fayetteville, N.Y.) 2021 May;92:41-52
Alcohol (Fayetteville, N.Y.) 2021 May;92:41-52
Danthron ameliorates obesity and MAFLD through activating the interplay between PPARα/RXRα heterodimer and adiponectin receptor 2.
Ma C, Wang Z, Xia R, Wei L, Zhang C, Zhang J, Zhao L, Wu H, Kang L, Yang S
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 May;137:111344
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 May;137:111344
The near-infrared dye IR-61 restores erectile function in a streptozotocin-induced diabetes model via mitochondrial protection.
Yue XF, Shen CX, Wang JW, Dai LY, Fang Q, Long L, Zhi Y, Li XR, Wang YW, Shen GF, Liu ZJ, Shi CM, Li WB
Asian journal of andrology 2021 May-Jun;23(3):249-258
Asian journal of andrology 2021 May-Jun;23(3):249-258
Effect of circular RNA, mmu_circ_0000296, on neuronal apoptosis in chronic cerebral ischaemia via the miR-194-5p/Runx3/Sirt1 axis.
Huang K, Yang C, Zheng J, Liu X, Liu J, Che D, Xue Y, An P, Wang D, Ruan X, Yu B
Cell death discovery 2021 May 29;7(1):124
Cell death discovery 2021 May 29;7(1):124
Exercise improves lipid droplet metabolism disorder through activation of AMPK-mediated lipophagy in NAFLD.
Li H, Dun Y, Zhang W, You B, Liu Y, Fu S, Qiu L, Cheng J, Ripley-Gonzalez JW, Liu S
Life sciences 2021 May 15;273:119314
Life sciences 2021 May 15;273:119314
SIRT1 inhibitors mitigate radiation-induced GI syndrome by enhancing intestinal-stem-cell survival.
Fu G, Chen S, Liang L, Li X, Tang P, Rao X, Pan M, Xu X, Li Y, Yao Y, Zhou Y, Gao J, Mo S, Cai S, Peng J, Zhang Z, Clevers H, Gao J, Hua G
Cancer letters 2021 Mar 31;501:20-30
Cancer letters 2021 Mar 31;501:20-30
Amelioration of Juglanin against LPS-Induced Activation of NLRP3 Inflammasome in Chondrocytes Mediated by SIRT1.
Wang T, Wang J, Sun T, Li Y
Inflammation 2021 Jun;44(3):1119-1129
Inflammation 2021 Jun;44(3):1119-1129
Melatonin inhibits lipid accumulation to repress prostate cancer progression by mediating the epigenetic modification of CES1.
Zhou L, Zhang C, Yang X, Liu L, Hu J, Hou Y, Tao H, Sugimura H, Chen Z, Wang L, Chen K
Clinical and translational medicine 2021 Jun;11(6):e449
Clinical and translational medicine 2021 Jun;11(6):e449
CD38 deficiency alleviates Ang II-induced vascular remodeling by inhibiting small extracellular vesicle-mediated vascular smooth muscle cell senescence in mice.
Gan L, Liu D, Liu J, Chen E, Chen C, Liu L, Hu H, Guan X, Ma W, Zhang Y, He Y, Liu B, Tang S, Jiang W, Xue J, Xin H
Signal transduction and targeted therapy 2021 Jun 11;6(1):223
Signal transduction and targeted therapy 2021 Jun 11;6(1):223
The SESAME complex regulates cell senescence through the generation of acetyl-CoA.
Chen W, Yu X, Wu Y, Tang J, Yu Q, Lv X, Zha Z, Hu B, Li X, Chen J, Ma L, Workman JL, Li S
Nature metabolism 2021 Jul;3(7):983-1000
Nature metabolism 2021 Jul;3(7):983-1000
Theaflavin Promotes Mitochondrial Abundance and Glucose Absorption in Myotubes by Activating the CaMKK2-AMPK Signal Axis via Calcium-Ion Influx.
Qu Z, Liu A, Liu C, Tang Q, Zhan L, Xiao W, Huang J, Liu Z, Zhang S
Journal of agricultural and food chemistry 2021 Jul 28;69(29):8144-8159
Journal of agricultural and food chemistry 2021 Jul 28;69(29):8144-8159
Selenium Deficiency-Induced Damage and Altered Expression of Mitochondrial Biogenesis Markers in the Kidneys of Mice.
Lai H, Nie T, Zhang Y, Chen Y, Tao J, Lin T, Ge T, Li F, Li H
Biological trace element research 2021 Jan;199(1):185-196
Biological trace element research 2021 Jan;199(1):185-196
Hyperglycemia-reduced NAD(+) biosynthesis impairs corneal epithelial wound healing in diabetic mice.
Li Y, Li J, Zhao C, Yang L, Qi X, Wang X, Zhou Q, Shi W
Metabolism: clinical and experimental 2021 Jan;114:154402
Metabolism: clinical and experimental 2021 Jan;114:154402
MAR1 suppresses inflammatory response in LPS-induced RAW 264.7 macrophages and human primary peripheral blood mononuclear cells via the SIRT1/PGC-1α/PPAR-γ pathway.
Wang W, Xu RL, He P, Chen R
Journal of inflammation (London, England) 2021 Feb 8;18(1):8
Journal of inflammation (London, England) 2021 Feb 8;18(1):8
The miRNA199a/SIRT1/P300/Yy1/sST2 signaling axis regulates adverse cardiac remodeling following MI.
Asensio-Lopez MC, Sassi Y, Soler F, Fernandez Del Palacio MJ, Pascual-Figal D, Lax A
Scientific reports 2021 Feb 16;11(1):3915
Scientific reports 2021 Feb 16;11(1):3915
Abdominal Massage Alleviates Skeletal Muscle Insulin Resistance by Regulating the AMPK/SIRT1/PGC-1α Signaling Pathway.
Han Y, Lu Z, Chen S, Zhong C, Yan M, Wang H, Meng M, Liu M
Cell biochemistry and biophysics 2021 Dec;79(4):895-903
Cell biochemistry and biophysics 2021 Dec;79(4):895-903
Dimethyl fumarate ameliorates endotoxin-induced acute kidney injury against macrophage oxidative stress.
Zhou K, Xie M, Yi S, Tang Y, Luo H, Xiao Q, Xiao J, Li Y
Renal failure 2021 Dec;43(1):1229-1239
Renal failure 2021 Dec;43(1):1229-1239
Resveratrol and its derivative pterostilbene attenuate oxidative stress-induced intestinal injury by improving mitochondrial redox homeostasis and function via SIRT1 signaling.
Chen Y, Zhang H, Ji S, Jia P, Chen Y, Li Y, Wang T
Free radical biology & medicine 2021 Dec;177:1-14
Free radical biology & medicine 2021 Dec;177:1-14
Long non-coding RNA MCM3AP-AS1 protects chondrocytes ATDC5 and CHON-001 from IL-1β-induced inflammation via regulating miR-138-5p/SIRT1.
Shi J, Cao F, Chang Y, Xin C, Jiang X, Xu J, Lu S
Bioengineered 2021 Dec;12(1):1445-1456
Bioengineered 2021 Dec;12(1):1445-1456
Ginsenoside Rg5 Improves Insulin Resistance and Mitochondrial Biogenesis of Liver via Regulation of the Sirt1/PGC-1α Signaling Pathway in db/db Mice.
Zhu Y, Yang H, Deng J, Fan D
Journal of agricultural and food chemistry 2021 Aug 4;69(30):8428-8439
Journal of agricultural and food chemistry 2021 Aug 4;69(30):8428-8439
Curcumin and Resveratrol Improve Muscle Function and Structure through Attenuation of Proteolytic Markers in Experimental Cancer-Induced Cachexia.
Penedo-Vázquez A, Duran X, Mateu J, López-Postigo A, Barreiro E
Molecules (Basel, Switzerland) 2021 Aug 13;26(16)
Molecules (Basel, Switzerland) 2021 Aug 13;26(16)
Melatonin Ameliorates Lipopolysaccharide-Induced Microglial Inflammation via Triggering SIRT1/HMGB1 Signaling Axis.
Chibaatar E, Le K, Abdoulaye IA, Wu S, Guo Y
Journal of molecular neuroscience : MN 2021 Apr;71(4):691-701
Journal of molecular neuroscience : MN 2021 Apr;71(4):691-701
Cigarette smoke-inactivated SIRT1 promotes autophagy-dependent senescence of alveolar epithelial type 2 cells to induce pulmonary fibrosis.
Zhang Y, Huang W, Zheng Z, Wang W, Yuan Y, Hong Q, Lin J, Li X, Meng Y
Free radical biology & medicine 2021 Apr;166:116-127
Free radical biology & medicine 2021 Apr;166:116-127
Corrigendum to article "Quantitative proteomics reveals that long non-coding RNA MALAT1 interacts with DBC1 to regulate p53 acetylation''.
Chen R, Liu Y, Zhuang H, Yang B, Hei K, Xiao M, Hou C, Gao H, Zhang X, Jia C, Li L, Li Y, Zhang N
Nucleic acids research 2021 Apr 19;49(7):4199-4202
Nucleic acids research 2021 Apr 19;49(7):4199-4202
Ketamine ameliorates hypoxia-induced endothelial injury in human umbilical vein endothelial cells.
Zhou X, Liu J, Yang S, Su Y, Meng Z, Hu Y
Clinics (Sao Paulo, Brazil) 2020;75:e1865
Clinics (Sao Paulo, Brazil) 2020;75:e1865
Time-Restricted Feeding Reduces the Detrimental Effects of a High-Fat Diet, Possibly by Modulating the Circadian Rhythm of Hepatic Lipid Metabolism and Gut Microbiota.
Ye Y, Xu H, Xie Z, Wang L, Sun Y, Yang H, Hu D, Mao Y
Frontiers in nutrition 2020;7:596285
Frontiers in nutrition 2020;7:596285
Effect of Quercetin on PC12 Alzheimer's Disease Cell Model Induced by Aβ (25-35) and Its Mechanism Based on Sirtuin1/Nrf2/HO-1 Pathway.
Yu X, Li Y, Mu X
BioMed research international 2020;2020:8210578
BioMed research international 2020;2020:8210578
A Newly Synthesized Rhamnoside Derivative Alleviates Alzheimer's Amyloid-β-Induced Oxidative Stress, Mitochondrial Dysfunction, and Cell Senescence through Upregulating SIRT3.
Li Y, Lu J, Cao X, Zhao H, Gao L, Xia P, Pei G
Oxidative medicine and cellular longevity 2020;2020:7698560
Oxidative medicine and cellular longevity 2020;2020:7698560
Cumulative Effect of Cardiovascular Risk Factors on Regulation of AMPK/SIRT1-PGC-1α-SIRT3 Pathway in the Human Erectile Tissue.
Pereira AS, Gouveia AM, Tomada N, Rodrigues AR, Neves D
Oxidative medicine and cellular longevity 2020;2020:1525949
Oxidative medicine and cellular longevity 2020;2020:1525949
Septin4 Prevents PDGF-BB-induced HAVSMC Phenotypic Transformation, Proliferation and Migration by Promoting SIRT1-STAT3 Deacetylation and Dephosphorylation.
Zhang N, Zhang Y, You S, Tian Y, Lu S, Cao L, Sun Y
International journal of biological sciences 2020;16(4):708-718
International journal of biological sciences 2020;16(4):708-718
Astragalus Polysaccharides Inhibits Tumorigenesis and Lipid Metabolism Through miR-138-5p/SIRT1/SREBP1 Pathway in Prostate Cancer.
Guo S, Ma B, Jiang X, Li X, Jia Y
Frontiers in pharmacology 2020;11:598
Frontiers in pharmacology 2020;11:598
Quercetin Attenuates Atherosclerosis via Modulating Oxidized LDL-Induced Endothelial Cellular Senescence.
Jiang YH, Jiang LY, Wang YC, Ma DF, Li X
Frontiers in pharmacology 2020;11:512
Frontiers in pharmacology 2020;11:512
MicroRNA-34a Inhibition Alleviates Lung Injury in Cecal Ligation and Puncture Induced Septic Mice.
Chen S, Ding R, Hu Z, Yin X, Xiao F, Zhang W, Yan S, Lv C
Frontiers in immunology 2020;11:1829
Frontiers in immunology 2020;11:1829
Exosomes derived from GDNF-modified human adipose mesenchymal stem cells ameliorate peritubular capillary loss in tubulointerstitial fibrosis by activating the SIRT1/eNOS signaling pathway.
Chen L, Wang Y, Li S, Zuo B, Zhang X, Wang F, Sun D
Theranostics 2020;10(20):9425-9442
Theranostics 2020;10(20):9425-9442
SIRT1-dependent mitochondrial biogenesis supports therapeutic effects of resveratrol against neurodevelopment damage by fluoride.
Zhao Q, Tian Z, Zhou G, Niu Q, Chen J, Li P, Dong L, Xia T, Zhang S, Wang A
Theranostics 2020;10(11):4822-4838
Theranostics 2020;10(11):4822-4838
miR-29a Modulates GSK3β/SIRT1-Linked Mitochondrial Proteostatic Stress to Ameliorate Mouse Non-Alcoholic Steatohepatitis.
Yang YL, Wang PW, Wang FS, Lin HY, Huang YH
International journal of molecular sciences 2020 Sep 19;21(18)
International journal of molecular sciences 2020 Sep 19;21(18)
Consumption of a Blueberry-Enriched Diet by Women for 6 Weeks Alters Determinants of Human Muscle Progenitor Cell Function.
Blum JE, Gheller BJ, Hwang S, Bender E, Gheller M, Thalacker-Mercer AE
The Journal of nutrition 2020 Sep 1;150(9):2412-2418
The Journal of nutrition 2020 Sep 1;150(9):2412-2418
Sodium butyrate promotes milk fat synthesis in bovine mammary epithelial cells via GPR41 and its downstream signalling pathways.
Cheng J, Zhang Y, Ge Y, Li W, Cao Y, Qu Y, Liu S, Guo Y, Fu S, Liu J
Life sciences 2020 Oct 15;259:118375
Life sciences 2020 Oct 15;259:118375
Melatonin Rescues the Ti Particle-Impaired Osteogenic Potential of Bone Marrow Mesenchymal Stem Cells via the SIRT1/SOD2 Signaling Pathway.
Zhang Y, Zhu X, Wang G, Chen L, Yang H, He F, Lin J
Calcified tissue international 2020 Nov;107(5):474-488
Calcified tissue international 2020 Nov;107(5):474-488
Revealing active components, action targets and molecular mechanism of Gandi capsule for treating diabetic nephropathy based on network pharmacology strategy.
Zhang Q, Ye Q, Huang X, Xu A, Liu Y, Qi J, Zhang H, Zhang J
BMC complementary medicine and therapies 2020 Nov 23;20(1):362
BMC complementary medicine and therapies 2020 Nov 23;20(1):362
A translational program that suppresses metabolism to shield the genome.
Balukoff NC, Ho JJD, Theodoridis PR, Wang M, Bokros M, Llanio LM, Krieger JR, Schatz JH, Lee S
Nature communications 2020 Nov 13;11(1):5755
Nature communications 2020 Nov 13;11(1):5755
Anomalous AMPK-regulated angiotensin AT(1)R expression and SIRT1-mediated mitochondrial biogenesis at RVLM in hypertension programming of offspring to maternal high fructose exposure.
Chao YM, Wu KLH, Tsai PC, Tain YL, Leu S, Lee WC, Chan JYH
Journal of biomedical science 2020 May 23;27(1):68
Journal of biomedical science 2020 May 23;27(1):68
Melatonin enhances mitochondrial biogenesis and protects against rotenone-induced mitochondrial deficiency in early porcine embryos.
Niu YJ, Zhou W, Nie ZW, Shin KT, Cui XS
Journal of pineal research 2020 Mar;68(2):e12627
Journal of pineal research 2020 Mar;68(2):e12627
The effect of high glucose on the biological characteristics of nucleus pulposus-derived mesenchymal stem cells.
Liu Y, Li Y, Nan LP, Wang F, Zhou SF, Wang JC, Feng XM, Zhang L
Cell biochemistry and function 2020 Mar;38(2):130-140
Cell biochemistry and function 2020 Mar;38(2):130-140
Berbamine ameliorates ethanol-induced liver injury by inhibition of hepatic inflammation in mice.
Liu XY, Chen GN, DU GM, Pan Y, Song WQ, Jiang TW, Liu HL
Chinese journal of natural medicines 2020 Mar;18(3):186-195
Chinese journal of natural medicines 2020 Mar;18(3):186-195
The effect of swimming exercise and diet on the hypothalamic inflammation of ApoE-/- mice based on SIRT1-NF-κB-GnRH expression.
Wang X, Yang J, Lu T, Zhan Z, Wei W, Lyu X, Jiang Y, Xue X
Aging 2020 Jun 9;12(11):11085-11099
Aging 2020 Jun 9;12(11):11085-11099
Satellite Cells and Markers of Muscle Regeneration during Unloading and Reloading: Effects of Treatment with Resveratrol and Curcumin.
Mañas-García L, Guitart M, Duran X, Barreiro E
Nutrients 2020 Jun 23;12(6)
Nutrients 2020 Jun 23;12(6)
Insufficiency of melatonin in follicular fluid is a reversible cause for advanced maternal age-related aneuploidy in oocytes.
Zhang M, Lu Y, Chen Y, Zhang Y, Xiong B
Redox biology 2020 Jan;28:101327
Redox biology 2020 Jan;28:101327
Differential structural features in soleus and gastrocnemius of carnitine-treated cancer cachectic rats.
Busquets S, Pérez-Peiró M, Salazar-Degracia A, Argilés JM, Serpe R, Rojano-Toimil A, López-Soriano FJ, Barreiro E
Journal of cellular physiology 2020 Jan;235(1):526-537
Journal of cellular physiology 2020 Jan;235(1):526-537
Antrodan Alleviates High-Fat and High-Fructose Diet-Induced Fatty Liver Disease in C57BL/6 Mice Model via AMPK/Sirt1/SREBP-1c/PPARγ Pathway.
Chyau CC, Wang HF, Zhang WJ, Chen CC, Huang SH, Chang CC, Peng RY
International journal of molecular sciences 2020 Jan 6;21(1)
International journal of molecular sciences 2020 Jan 6;21(1)
Spermidine alleviates cardiac aging by improving mitochondrial biogenesis and function.
Wang J, Li S, Wang J, Wu F, Chen Y, Zhang H, Guo Y, Lin Y, Li L, Yu X, Liu T, Zhao Y
Aging 2020 Jan 6;12(1):650-671
Aging 2020 Jan 6;12(1):650-671
Muscle Phenotype, Proteolysis, and Atrophy Signaling During Reloading in Mice: Effects of Curcumin on the Gastrocnemius.
Mañas-García L, Bargalló N, Gea J, Barreiro E
Nutrients 2020 Jan 31;12(2)
Nutrients 2020 Jan 31;12(2)
Ubiquinol-10 delays postovulatory oocyte aging by improving mitochondrial renewal in pigs.
Niu YJ, Zhou W, Nie ZW, Zhou D, Xu YN, Ock SA, Yan CG, Cui XS
Aging 2020 Jan 20;12(2):1256-1271
Aging 2020 Jan 20;12(2):1256-1271
Neuroinflammation induced by secretion of acetylated HMGB1 from activated microglia in hippocampi of mice following chronic cold exposure.
Xu B, Lang LM, Lian S, Guo JR, Wang JF, Liu J, Yang HM, Li SZ
Brain research 2020 Jan 1;1726:146495
Brain research 2020 Jan 1;1726:146495
Anti-insulin resistance effects of salidroside through mitochondrial quality control.
You B, Dun Y, Zhang W, Jiang L, Li H, Xie M, Liu Y, Liu S
The Journal of endocrinology 2020 Feb;244(2):383-393
The Journal of endocrinology 2020 Feb;244(2):383-393
GABA-mediated activated microglia induce neuroinflammation in the hippocampus of mice following cold exposure through the NLRP3 inflammasome and NF-κB signaling pathways.
Lang L, Xu B, Yuan J, Li S, Lian S, Chen Y, Guo J, Yang H
International immunopharmacology 2020 Dec;89(Pt B):106908
International immunopharmacology 2020 Dec;89(Pt B):106908
Fengbaisan suppresses endoplasmic reticulum stress by up-regulating SIRT1 expression to protect rats with chronic obstructive pulmonary diseases.
Wang Y, Su NX, Pan SG, Ge XP, Dai XP
Pharmaceutical biology 2020 Dec;58(1):878-885
Pharmaceutical biology 2020 Dec;58(1):878-885
Functional Food XingJiuTang Attenuates Alcohol-Induced Liver Injury by Regulating SIRT1/Nrf-2 Signaling Pathway.
Hao J, Ding Y, Shi W, Zhang C, Li R
Chemistry & biodiversity 2020 Dec;17(12):e2000619
Chemistry & biodiversity 2020 Dec;17(12):e2000619
Neuroprotective effects and mechanisms of action of nicotinamide mononucleotide (NMN) in a photoreceptor degenerative model of retinal detachment.
Chen X, Amorim JA, Moustafa GA, Lee JJ, Yu Z, Ishihara K, Iesato Y, Barbisan P, Ueta T, Togka KA, Lu L, Sinclair DA, Vavvas DG
Aging 2020 Dec 29;12(24):24504-24521
Aging 2020 Dec 29;12(24):24504-24521
Mitochondrial Nuclear Retrograde Regulator 1 (MNRR1) rescues the cellular phenotype of MELAS by inducing homeostatic mechanisms.
Aras S, Purandare N, Gladyck S, Somayajulu-Nitu M, Zhang K, Wallace DC, Grossman LI
Proceedings of the National Academy of Sciences of the United States of America 2020 Dec 15;117(50):32056-32065
Proceedings of the National Academy of Sciences of the United States of America 2020 Dec 15;117(50):32056-32065
Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism.
Fu Y, Sun Y, Wang M, Hou Y, Huang W, Zhou D, Wang Z, Yang S, Tang W, Zhen J, Li Y, Wang X, Liu M, Zhang Y, Wang B, Liu G, Yu X, Sun J, Zhang C, Yi F
Cell metabolism 2020 Dec 1;32(6):1052-1062.e8
Cell metabolism 2020 Dec 1;32(6):1052-1062.e8
WWP2 regulates SIRT1-STAT3 acetylation and phosphorylation involved in hypertensive angiopathy.
Zhang Y, You S, Tian Y, Lu S, Cao L, Sun Y, Zhang N
Journal of cellular and molecular medicine 2020 Aug;24(16):9041-9054
Journal of cellular and molecular medicine 2020 Aug;24(16):9041-9054
Atorvastatin promotes bone formation in aged apoE(-/-) mice through the Sirt1-Runx2 axis.
Hong W, Wei Z, Qiu Z, Li Z, Fu C, Ye Z, Xu X
Journal of orthopaedic surgery and research 2020 Aug 6;15(1):303
Journal of orthopaedic surgery and research 2020 Aug 6;15(1):303
Schisandrin ameliorates cognitive deficits, endoplasmic reticulum stress and neuroinflammation in streptozotocin (STZ)-induced Alzheimer's disease rats.
Song L, Piao Z, Yao L, Zhang L, Lu Y
Experimental animals 2020 Aug 5;69(3):363-373
Experimental animals 2020 Aug 5;69(3):363-373
Pum2 mediates Sirt1 mRNA decay and exacerbates hypoxia/reoxygenation-induced cardiomyocyte apoptosis.
Cao Y, Liu C, Wang Q, Wang W, Tao E, Wan L
Experimental cell research 2020 Aug 1;393(1):112058
Experimental cell research 2020 Aug 1;393(1):112058
Associations of sirtuins with clinicopathological variables and prognosis in human ovarian cancer.
He Q, Chen K, Ye R, Dai N, Guo P, Wang L
Oncology letters 2020 Apr;19(4):3278-3288
Oncology letters 2020 Apr;19(4):3278-3288
Comprehensive Analysis of Expression and Prognostic Value of Sirtuins in Ovarian Cancer.
Sun X, Wang S, Li Q
Frontiers in genetics 2019;10:879
Frontiers in genetics 2019;10:879
Propofol Alleviates DNA Damage Induced by Oxygen Glucose Deprivation and Reperfusion via FoxO1 Nuclear Translocation in H9c2 Cells.
Zhou D, Zhuang J, Wang Y, Zhao D, Zhao L, Zhu S, Pu J, Yin M, Zhang H, Wang Z, Hong J
Frontiers in physiology 2019;10:223
Frontiers in physiology 2019;10:223
Protective Effects of Dioscin Against Doxorubicin-Induced Hepatotoxicity Via Regulation of Sirt1/FOXO1/NF-κb Signal.
Song S, Chu L, Liang H, Chen J, Liang J, Huang Z, Zhang B, Chen X
Frontiers in pharmacology 2019;10:1030
Frontiers in pharmacology 2019;10:1030
Feeding restriction alleviates high carbohydrate diet-induced oxidative stress and inflammation of Megalobrama amblycephala by activating the AMPK-SIRT1 pathway.
Xu C, Liu WB, Remø SC, Wang BK, Shi HJ, Zhang L, Liu JD, Li XF
Fish & shellfish immunology 2019 Sep;92:637-648
Fish & shellfish immunology 2019 Sep;92:637-648
A positive feedback loop of SIRT1 and miR17HG promotes the repair of DNA double-stranded breaks.
Xie L, Huang R, Liu S, Wu W, Su A, Li R, Liu X, Lei Y, Sun H, Liu X, Xu S
Cell cycle (Georgetown, Tex.) 2019 Sep;18(17):2110-2123
Cell cycle (Georgetown, Tex.) 2019 Sep;18(17):2110-2123
Partially Hydrolyzed Guar Gum Attenuates d-Galactose-Induced Oxidative Stress and Restores Gut Microbiota in Rats.
Liu X, Wu C, Han D, Liu J, Liu H, Jiang Z
International journal of molecular sciences 2019 Sep 30;20(19)
International journal of molecular sciences 2019 Sep 30;20(19)
Myricanol modulates skeletal muscle-adipose tissue crosstalk to alleviate high-fat diet-induced obesity and insulin resistance.
Shen S, Liao Q, Zhang T, Pan R, Lin L
British journal of pharmacology 2019 Oct;176(20):3983-4001
British journal of pharmacology 2019 Oct;176(20):3983-4001
SIRT1 activation attenuates cardiac fibrosis by endothelial-to-mesenchymal transition.
Liu ZH, Zhang Y, Wang X, Fan XF, Zhang Y, Li X, Gong YS, Han LP
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Oct;118:109227
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Oct;118:109227
Anti-ageing and antioxidant effects of sulfate oligosaccharides from green algae Ulva lactuca and Enteromorpha prolifera in SAMP8 mice.
Liu XY, Liu D, Lin GP, Wu YJ, Gao LY, Ai C, Huang YF, Wang MF, El-Seedi HR, Chen XH, Zhao C
International journal of biological macromolecules 2019 Oct 15;139:342-351
International journal of biological macromolecules 2019 Oct 15;139:342-351
The protective effect of lithocholic acid on the intestinal epithelial barrier is mediated by the vitamin D receptor via a SIRT1/Nrf2 and NF-κB dependent mechanism in Caco-2 cells.
Yao B, He J, Yin X, Shi Y, Wan J, Tian Z
Toxicology letters 2019 Nov;316:109-118
Toxicology letters 2019 Nov;316:109-118
Sodium/calcium overload and Sirt1/Nrf2/OH-1 pathway are critical events in mercuric chloride-induced nephrotoxicity.
Li S, Jiang X, Luo Y, Zhou B, Shi M, Liu F, Sha A
Chemosphere 2019 Nov;234:579-588
Chemosphere 2019 Nov;234:579-588
The protective effect of oleanolic acid on NMDA-induced MLE-12 cells apoptosis and lung injury in mice by activating SIRT1 and reducing NF-κB acetylation.
Peng XP, Li XH, Li Y, Huang XT, Luo ZQ
International immunopharmacology 2019 May;70:520-529
International immunopharmacology 2019 May;70:520-529
Osteocyte TSC1 promotes sclerostin secretion to restrain osteogenesis in mice.
Liu W, Wang Z, Yang J, Wang Y, Li K, Huang B, Yan B, Wang T, Li M, Zou Z, Yang J, Xiao G, Cui ZK, Liu A, Bai X
Open biology 2019 May 31;9(5):180262
Open biology 2019 May 31;9(5):180262
CERKL regulates autophagy via the NAD-dependent deacetylase SIRT1.
Hu X, Lu Z, Yu S, Reilly J, Liu F, Jia D, Qin Y, Han S, Liu X, Qu Z, Lv Y, Li J, Huang Y, Jiang T, Jia H, Wang Q, Liu J, Shu X, Tang Z, Liu M
Autophagy 2019 Mar;15(3):453-465
Autophagy 2019 Mar;15(3):453-465
Neuroprotective Effects of Ginsenosides against Cerebral Ischemia.
Cheng Z, Zhang M, Ling C, Zhu Y, Ren H, Hong C, Qin J, Liu T, Wang J
Molecules (Basel, Switzerland) 2019 Mar 20;24(6)
Molecules (Basel, Switzerland) 2019 Mar 20;24(6)
Sirtuin-mediated deacetylation of hnRNP A1 suppresses glycolysis and growth in hepatocellular carcinoma.
Yang H, Zhu R, Zhao X, Liu L, Zhou Z, Zhao L, Liang B, Ma W, Zhao J, Liu J, Huang G
Oncogene 2019 Jun;38(25):4915-4931
Oncogene 2019 Jun;38(25):4915-4931
Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents.
Wang Z, Chen Z, Jiang Z, Luo P, Liu L, Huang Y, Wang H, Wang Y, Long L, Tan X, Liu D, Jin T, Wang Y, Wang Y, Liao F, Zhang C, Chen L, Gan Y, Liu Y, Yang F, Huang C, Miao H, Chen J, Cheng T, Fu X, Shi C
Nature communications 2019 Jun 10;10(1):2538
Nature communications 2019 Jun 10;10(1):2538
High fructose diet induces early mortality via autophagy factors accumulation in the rostral ventrolateral medulla as ameliorated by pioglitazone.
Lin IC, Wu CW, Tain YL, Chen IC, Hung CY, Wu KLH
The Journal of nutritional biochemistry 2019 Jul;69:87-97
The Journal of nutritional biochemistry 2019 Jul;69:87-97
The effect of intervertebral disc degenerative change on biological characteristics of nucleus pulposus mesenchymal stem cell: an in vitro study in rats.
Liu Y, Li Y, Huang ZN, Wang ZY, Nan LP, Wang F, Zhou SF, Wang JC, Feng XM, Zhang L
Connective tissue research 2019 Jul;60(4):376-388
Connective tissue research 2019 Jul;60(4):376-388
Abnormal expression of SIRTs in psoriasis: Decreased expression of SIRT 1-5 and increased expression of SIRT 6 and 7.
Fan X, Yan K, Meng Q, Sun R, Yang X, Yuan D, Li F, Deng H
International journal of molecular medicine 2019 Jul;44(1):157-171
International journal of molecular medicine 2019 Jul;44(1):157-171
Complement C3 activation regulates the production of tRNA-derived fragments Gly-tRFs and promotes alcohol-induced liver injury and steatosis.
Zhong F, Hu Z, Jiang K, Lei B, Wu Z, Yuan G, Luo H, Dong C, Tang B, Zheng C, Yang S, Zeng Y, Guo Z, Yu S, Su H, Zhang G, Qiu X, Tomlinson S, He S
Cell research 2019 Jul;29(7):548-561
Cell research 2019 Jul;29(7):548-561
Ambient particulate matter attenuates Sirtuin1 and augments SREBP1-PIR axis to induce human pulmonary fibroblast inflammation: molecular mechanism of microenvironment associated with COPD.
Tien CP, Chen CH, Lin WY, Liu CS, Liu KJ, Hsiao M, Chang YC, Hung SC
Aging 2019 Jul 12;11(13):4654-4671
Aging 2019 Jul 12;11(13):4654-4671
HMGB1-mediated differential response on hippocampal neurotransmitter disorder and neuroinflammation in adolescent male and female mice following cold exposure.
Xu B, Zang SC, Li SZ, Guo JR, Wang JF, Wang D, Zhang LP, Yang HM, Lian S
Brain, behavior, and immunity 2019 Feb;76:223-235
Brain, behavior, and immunity 2019 Feb;76:223-235
Catalpol alleviates adriamycin-induced nephropathy by activating the SIRT1 signalling pathway in vivo and in vitro.
Zhang J, Bi R, Meng Q, Wang C, Huo X, Liu Z, Wang C, Sun P, Sun H, Ma X, Wu J, Liu K
British journal of pharmacology 2019 Dec;176(23):4558-4573
British journal of pharmacology 2019 Dec;176(23):4558-4573
Bone marrow mesenchymal stem cells could reduce the toxic effects of hexavalent chromium on the liver by decreasing endoplasmic reticulum stress-mediated apoptosis via SIRT1/HIF-1α signaling pathway in rats.
Zhao Y, Yan J, Li AP, Zhang ZL, Li ZR, Guo KJ, Zhao KC, Ruan Q, Guo L
Toxicology letters 2019 Aug;310:31-38
Toxicology letters 2019 Aug;310:31-38
MicroRNA-128-3p aggravates doxorubicin-induced liver injury by promoting oxidative stress via targeting Sirtuin-1.
Zhao X, Jin Y, Li L, Xu L, Tang Z, Qi Y, Yin L, Peng J
Pharmacological research 2019 Aug;146:104276
Pharmacological research 2019 Aug;146:104276
Corneal Denervation Causes Epithelial Apoptosis Through Inhibiting NAD+ Biosynthesis.
Li Y, Ma X, Li J, Yang L, Zhao X, Qi X, Zhang X, Zhou Q, Shi W
Investigative ophthalmology & visual science 2019 Aug 1;60(10):3538-3546
Investigative ophthalmology & visual science 2019 Aug 1;60(10):3538-3546
Nicotinamide phosphoribosyl transferase regulates cell growth via the Sirt1/P53 signaling pathway and is a prognosis marker in colorectal cancer.
Pan JH, Zhou H, Zhu SB, Huang JL, Zhao XX, Ding H, Qin L, Pan YL
Journal of cellular physiology 2019 Apr;234(4):4385-4395
Journal of cellular physiology 2019 Apr;234(4):4385-4395
Effects of SIRT1 silencing on viability, invasion and metastasis of human glioma cell lines.
Li Y, Chen X, Cui Y, Wei Q, Chen S, Wang X
Oncology letters 2019 Apr;17(4):3701-3708
Oncology letters 2019 Apr;17(4):3701-3708
Resveratrol Improves the Energy Sensing and Glycolipid Metabolism of Blunt Snout Bream Megalobrama amblycephala Fed High-Carbohydrate Diets by Activating the AMPK-SIRT1-PGC-1α Network.
Shi HJ, Xu C, Liu MY, Wang BK, Liu WB, Chen DH, Zhang L, Xu CY, Li XF
Frontiers in physiology 2018;9:1258
Frontiers in physiology 2018;9:1258
Modified Si-Ni-San Decoction Ameliorates Central Fatigue by Improving Mitochondrial Biogenesis in the Rat Hippocampus.
Han C, Li F, Liu Y, Ma J, Yu X, Wu X, Zhang W, Li D, Chen D, Dai N, Lin B, Wu F, Mao M
Evidence-based complementary and alternative medicine : eCAM 2018;2018:9452127
Evidence-based complementary and alternative medicine : eCAM 2018;2018:9452127
Electroacupuncture: A Feasible Sirt1 Promoter Which Modulates Metainflammation in Diet-Induced Obesity Rats.
Luo D, Liu L, Liang FX, Yu ZM, Chen R
Evidence-based complementary and alternative medicine : eCAM 2018;2018:5302049
Evidence-based complementary and alternative medicine : eCAM 2018;2018:5302049
2,3,5,4'-Tetrahydroxystilbene-2-O-β-glucoside potentiates self-renewal of human dental pulp stem cells via the AMPK/ERK/SIRT1 axis.
Lin CY, Chin YT, Kuo PJ, Lee HW, Huang HM, Lin HY, Weng IT, Hsiung CN, Chan YH, Lee SY
International endodontic journal 2018 Oct;51(10):1159-1170
International endodontic journal 2018 Oct;51(10):1159-1170
Layer-by-layer assembled gold nanoshells for the intracellular delivery of miR-34a.
Goyal R, Kapadia CH, Melamed JR, Riley RS, Day ES
Cellular and molecular bioengineering 2018 Oct;11(5):383-396
Cellular and molecular bioengineering 2018 Oct;11(5):383-396
Cardioprotection of CAPE-oNO(2) against myocardial ischemia/reperfusion induced ROS generation via regulating the SIRT1/eNOS/NF-κB pathway in vivo and in vitro.
Li D, Wang X, Huang Q, Li S, Zhou Y, Li Z
Redox biology 2018 May;15:62-73
Redox biology 2018 May;15:62-73
Synergistic Effects of Salvianolic Acid B and Puerarin on Cerebral Ischemia Reperfusion Injury.
Ling C, Liang J, Zhang C, Li R, Mou Q, Qin J, Li X, Wang J
Molecules (Basel, Switzerland) 2018 Mar 2;23(3)
Molecules (Basel, Switzerland) 2018 Mar 2;23(3)
Regulation on SIRT1-PGC-1α/Nrf2 pathway together with selective inhibition of aldose reductase makes compound hr5F a potential agent for the treatment of diabetic complications.
Wang Z, Yuan S, Li Y, Zhang Z, Xiao W, Tang D, Ye K, Liu Z, Wang C, Zheng Y, Nie H, Chen H
Biochemical pharmacology 2018 Apr;150:54-63
Biochemical pharmacology 2018 Apr;150:54-63
Metformin Sensitizes Non-small Cell Lung Cancer Cells to an Epigallocatechin-3-Gallate (EGCG) Treatment by Suppressing the Nrf2/HO-1 Signaling Pathway.
Yu C, Jiao Y, Xue J, Zhang Q, Yang H, Xing L, Chen G, Wu J, Zhang S, Zhu W, Cao J
International journal of biological sciences 2017;13(12):1560-1569
International journal of biological sciences 2017;13(12):1560-1569
Resveratrol ameliorates diet-induced dysregulation of lipid metabolism in zebrafish (Danio rerio).
Ran G, Ying L, Li L, Yan Q, Yi W, Ying C, Wu H, Ye X
PloS one 2017;12(7):e0180865
PloS one 2017;12(7):e0180865
Regulation of autophagy by AMP-activated protein kinase/sirtuin 1 pathway reduces spinal cord neurons damage.
Yan P, Bai L, Lu W, Gao Y, Bi Y, Lv G
Iranian journal of basic medical sciences 2017 Sep;20(9):1029-1036
Iranian journal of basic medical sciences 2017 Sep;20(9):1029-1036
Quantitative proteomics reveals that long non-coding RNA MALAT1 interacts with DBC1 to regulate p53 acetylation.
Chen R, Liu Y, Zhuang H, Yang B, Hei K, Xiao M, Hou C, Gao H, Zhang X, Jia C, Li L, Li Y, Zhang N
Nucleic acids research 2017 Sep 29;45(17):9947-9959
Nucleic acids research 2017 Sep 29;45(17):9947-9959
Salidroside ameliorates sepsis-induced acute lung injury and mortality via downregulating NF-κB and HMGB1 pathways through the upregulation of SIRT1.
Lan KC, Chao SC, Wu HY, Chiang CL, Wang CC, Liu SH, Weng TI
Scientific reports 2017 Sep 20;7(1):12026
Scientific reports 2017 Sep 20;7(1):12026
The Effects of Resveratrol on Inflammation and Oxidative Stress in a Rat Model of Chronic Obstructive Pulmonary Disease.
Wang XL, Li T, Li JH, Miao SY, Xiao XZ
Molecules (Basel, Switzerland) 2017 Sep 12;22(9)
Molecules (Basel, Switzerland) 2017 Sep 12;22(9)
TRPC5 channel modulates endothelial cells senescence.
Li Z, Guo G, Wang H, Si X, Zhou G, Xiong Y, Li S, Dai R, Yang C
European journal of pharmacology 2017 May 5;802:27-35
European journal of pharmacology 2017 May 5;802:27-35
Resveratrol attenuates ICAM-1 expression and monocyte adhesiveness to TNF-α-treated endothelial cells: evidence for an anti-inflammatory cascade mediated by the miR-221/222/AMPK/p38/NF-κB pathway.
Liu CW, Sung HC, Lin SR, Wu CW, Lee CW, Lee IT, Yang YF, Yu IS, Lin SW, Chiang MH, Liang CJ, Chen YL
Scientific reports 2017 Mar 24;7:44689
Scientific reports 2017 Mar 24;7:44689
AMPK/α-Ketoglutarate Axis Regulates Intestinal Water and Ion Homeostasis in Young Pigs.
He L, Huang N, Li H, Tian J, Zhou X, Li T, Yao K, Wu G, Yin Y
Journal of agricultural and food chemistry 2017 Mar 22;65(11):2287-2298
Journal of agricultural and food chemistry 2017 Mar 22;65(11):2287-2298
Short- and Long-Term Hindlimb Immobilization and Reloading: Profile of Epigenetic Events in Gastrocnemius.
Chacon-Cabrera A, Gea J, Barreiro E
Journal of cellular physiology 2017 Jun;232(6):1415-1427
Journal of cellular physiology 2017 Jun;232(6):1415-1427
Hormetic effect of panaxatriol saponins confers neuroprotection in PC12 cells and zebrafish through PI3K/AKT/mTOR and AMPK/SIRT1/FOXO3 pathways.
Zhang C, Li C, Chen S, Li Z, Ma L, Jia X, Wang K, Bao J, Liang Y, Chen M, Li P, Su H, Lee SM, Liu K, Wan JB, He C
Scientific reports 2017 Jan 23;7:41082
Scientific reports 2017 Jan 23;7:41082
miR-138-5p suppresses autophagy in pancreatic cancer by targeting SIRT1.
Tian S, Guo X, Yu C, Sun C, Jiang J
Oncotarget 2017 Feb 14;8(7):11071-11082
Oncotarget 2017 Feb 14;8(7):11071-11082
Antiaging Effect of Inula britannica on Aging Mouse Model Induced by D-Galactose.
Chen H, Long Y, Guo L
Evidence-based complementary and alternative medicine : eCAM 2016;2016:6049083
Evidence-based complementary and alternative medicine : eCAM 2016;2016:6049083
The Polyphenol Oleuropein Aglycone Modulates the PARP1-SIRT1 Interplay: An In Vitro and In Vivo Study.
Luccarini I, Pantano D, Nardiello P, Cavone L, Lapucci A, Miceli C, Nediani C, Berti A, Stefani M, Casamenti F
Journal of Alzheimer's disease : JAD 2016 Sep 6;54(2):737-50
Journal of Alzheimer's disease : JAD 2016 Sep 6;54(2):737-50
Capsaicin reactivates hMOF in gastric cancer cells and induces cell growth inhibition.
Wang F, Zhao J, Liu D, Zhao T, Lu Z, Zhu L, Cao L, Yang J, Jin J, Cai Y
Cancer biology & therapy 2016 Nov;17(11):1117-1125
Cancer biology & therapy 2016 Nov;17(11):1117-1125
Lycium barbarum polysaccharide attenuates high-fat diet-induced hepatic steatosis by up-regulating SIRT1 expression and deacetylase activity.
Jia L, Li W, Li J, Li Y, Song H, Luan Y, Qi H, Ma L, Lu X, Yang Y
Scientific reports 2016 Nov 8;6:36209
Scientific reports 2016 Nov 8;6:36209
Effects of physical exercise on myokines expression and brown adipose-like phenotype modulation in rats fed a high-fat diet.
Rocha-Rodrigues S, Rodríguez A, Gouveia AM, Gonçalves IO, Becerril S, Ramírez B, Beleza J, Frühbeck G, Ascensão A, Magalhães J
Life sciences 2016 Nov 15;165:100-108
Life sciences 2016 Nov 15;165:100-108
Sirtuin 1 Promotes Hyperoxia-Induced Lung Epithelial Cell Death Independent of NF-E2-Related Factor 2 Activation.
Potteti HR, Rajasekaran S, Rajamohan SB, Tamatam CR, Reddy NM, Reddy SP
American journal of respiratory cell and molecular biology 2016 May;54(5):697-706
American journal of respiratory cell and molecular biology 2016 May;54(5):697-706
Dioscin alleviates dimethylnitrosamine-induced acute liver injury through regulating apoptosis, oxidative stress and inflammation.
Zhang W, Yin L, Tao X, Xu L, Zheng L, Han X, Xu Y, Wang C, Peng J
Environmental toxicology and pharmacology 2016 Jul;45:193-201
Environmental toxicology and pharmacology 2016 Jul;45:193-201
Total Flavonoids from Rosa laevigata Michx Fruit Ameliorates Hepatic Ischemia/Reperfusion Injury through Inhibition of Oxidative Stress and Inflammation in Rats.
Tao X, Sun X, Xu L, Yin L, Han X, Qi Y, Xu Y, Zhao Y, Wang C, Peng J
Nutrients 2016 Jul 8;8(7)
Nutrients 2016 Jul 8;8(7)
Protective Effect of the Total Flavonoids from Rosa laevigata Michx Fruit on Renal Ischemia-Reperfusion Injury through Suppression of Oxidative Stress and Inflammation.
Zhao L, Xu L, Tao X, Han X, Yin L, Qi Y, Peng J
Molecules (Basel, Switzerland) 2016 Jul 21;21(7)
Molecules (Basel, Switzerland) 2016 Jul 21;21(7)
Interleukin-6-stimulated progranulin expression contributes to the malignancy of hepatocellular carcinoma cells by activating mTOR signaling.
Liu F, Zhang W, Yang F, Feng T, Zhou M, Yu Y, Yu X, Zhao W, Yi F, Tang W, Lu Y
Scientific reports 2016 Feb 16;6:21260
Scientific reports 2016 Feb 16;6:21260
Resveratrol Ameliorated Vascular Calcification by Regulating Sirt-1 and Nrf2.
Zhang P, Li Y, Du Y, Li G, Wang L, Zhou F
Transplantation proceedings 2016 Dec;48(10):3378-3386
Transplantation proceedings 2016 Dec;48(10):3378-3386
Expression of hMOF, but not HDAC4, is responsible for the global histone H4K16 acetylation in gastric carcinoma.
Zhu L, Yang J, Zhao L, Yu X, Wang L, Wang F, Cai Y, Jin J
International journal of oncology 2015;46(6):2535-45
International journal of oncology 2015;46(6):2535-45
RhNRG-1β Protects the Myocardium against Irradiation-Induced Damage via the ErbB2-ERK-SIRT1 Signaling Pathway.
Gu A, Jie Y, Sun L, Zhao S, E M, You Q
PloS one 2015;10(9):e0137337
PloS one 2015;10(9):e0137337
Curcumin treatment enhances the effect of exercise on mitochondrial biogenesis in skeletal muscle by increasing cAMP levels.
Ray Hamidie RD, Yamada T, Ishizawa R, Saito Y, Masuda K
Metabolism: clinical and experimental 2015 Oct;64(10):1334-47
Metabolism: clinical and experimental 2015 Oct;64(10):1334-47
Effects of Aging and Cardiovascular Disease Risk Factors on the Expression of Sirtuins in the Human Corpus Cavernosum.
Freitas M, Rodrigues AR, Tomada N, Fonseca J, Magalhães A, Gouveia AM, Neves D
The journal of sexual medicine 2015 Nov;12(11):2141-52
The journal of sexual medicine 2015 Nov;12(11):2141-52
Quadriceps muscle weakness and atrophy are associated with a differential epigenetic profile in advanced COPD.
Puig-Vilanova E, Martínez-Llorens J, Ausin P, Roca J, Gea J, Barreiro E
Clinical science (London, England : 1979) 2015 Jun;128(12):905-21
Clinical science (London, England : 1979) 2015 Jun;128(12):905-21
Expression of hMOF in different ovarian tissues and its effects on ovarian cancer prognosis.
Cai M, Hu Z, Liu J, Gao J, Tan M, Zhang D, Zhu L, Liu S, Hou R, Lin B
Oncology reports 2015 Feb;33(2):685-92
Oncology reports 2015 Feb;33(2):685-92
Natural mineral-rich water ingestion improves hepatic and fat glucocorticoid-signaling and increases sirtuin 1 in an animal model of metabolic syndrome.
Pereira CD, Severo M, Neves D, Ascensão A, Magalhães J, Guimarães JT, Monteiro R, Martins MJ
Hormone molecular biology and clinical investigation 2015 Feb;21(2):149-57
Hormone molecular biology and clinical investigation 2015 Feb;21(2):149-57
Sirt1 is involved in decreased bone formation in aged apolipoprotein E-deficient mice.
Hong W, Xu XY, Qiu ZH, Gao JJ, Wei ZY, Zhen L, Zhang XL, Ye ZB
Acta pharmacologica Sinica 2015 Dec;36(12):1487-96
Acta pharmacologica Sinica 2015 Dec;36(12):1487-96
Do epigenetic events take place in the vastus lateralis of patients with mild chronic obstructive pulmonary disease?
Puig-Vilanova E, Ausin P, Martinez-Llorens J, Gea J, Barreiro E
PloS one 2014;9(7):e102296
PloS one 2014;9(7):e102296
Tetramethylpyrazine ameliorates high glucose-induced endothelial dysfunction by increasing mitochondrial biogenesis.
Xu Q, Xia P, Li X, Wang W, Liu Z, Gao X
PloS one 2014;9(2):e88243
PloS one 2014;9(2):e88243
Ubiquitin-specific peptidase USP22 negatively regulates the STAT signaling pathway by deubiquitinating SIRT1.
Ao N, Liu Y, Feng H, Bian X, Li Z, Gu B, Zhao X, Liu Y
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2014;33(6):1863-75
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2014;33(6):1863-75
Effects of natural mineral-rich water consumption on the expression of sirtuin 1 and angiogenic factors in the erectile tissue of rats with fructose-induced metabolic syndrome.
Pereira CD, Severo M, Rafael L, Martins MJ, Neves D
Asian journal of andrology 2014 Jul-Aug;16(4):631-8
Asian journal of andrology 2014 Jul-Aug;16(4):631-8
The protease Omi regulates mitochondrial biogenesis through the GSK3β/PGC-1α pathway.
Xu R, Hu Q, Ma Q, Liu C, Wang G
Cell death & disease 2014 Aug 14;5(8):e1373
Cell death & disease 2014 Aug 14;5(8):e1373
Long-term high-fat consumption leads to downregulation of Akt phosphorylation of eNOS at Ser1177 and upregulation of Sirtuin-1 expression in rat cavernous tissue.
Tomada I, Negrão R, Almeida H, Neves D
Age (Dordrecht, Netherlands) 2014 Apr;36(2):597-611
Age (Dordrecht, Netherlands) 2014 Apr;36(2):597-611
Exogenous NAD(+) supplementation protects H9c2 cardiac myoblasts against hypoxia/reoxygenation injury via Sirt1-p53 pathway.
Liu L, Wang P, Liu X, He D, Liang C, Yu Y
Fundamental & clinical pharmacology 2014 Apr;28(2):180-9
Fundamental & clinical pharmacology 2014 Apr;28(2):180-9
Butyrate-producing probiotics reduce nonalcoholic fatty liver disease progression in rats: new insight into the probiotics for the gut-liver axis.
Endo H, Niioka M, Kobayashi N, Tanaka M, Watanabe T
PloS one 2013;8(5):e63388
PloS one 2013;8(5):e63388
MiR-138 induces renal carcinoma cell senescence by targeting EZH2 and is downregulated in human clear cell renal cell carcinoma.
Liang J, Zhang Y, Jiang G, Liu Z, Xiang W, Chen X, Chen Z, Zhao J
Oncology research 2013;21(2):83-91
Oncology research 2013;21(2):83-91
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Jurkat cells were subjected to SDS PAGE followed by western blot with 13161-1-AP(SIRT1 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-SIRT1 (IP:13161-1-AP, 4ug; Detection:13161-1-AP 1:500) with mouse testis tissue lysate 8000ug.
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The SIRT1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SIRT1. This antibody recognizes human,mouse,rat antigen. The SIRT1 antibody has been validated for the following applications: ELISA, IP, IHC, WB analysis.
