ABIN493460

antibody from antibodies-online

Targeting: SIRT1 SIR2L1

Western blot (Recommended by provider)

Antibody Data

Product number

ABIN493460

Provider

antibodies-online

Product name

anti-Sirtuin 1 (SIRT1) (AA 33-55) antibody

Antibody type

Polyclonal

Antigen

Synthetic peptide corresponding to amino acids 33-55 of Rat Sirtuin-1. Remarks: 100% homology to Mouse and Human Sirtuin-1. The epitope is common in Bovine, Cat, Zebrafish Sirtuin 1 protein.

Reactivity

Human, Mouse, Rat, Bovine, Chicken/Avian, Feline

Host

Rabbit

Isotype

IgG

Vial size

0.1 mg

Concentration

0.69-0.75 mg/ml (lot. specific)

Storage

Store the antibody undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

References

Submitted references

SIRT1 is significantly elevated in mouse and human prostate cancer.

Huffman DM, Grizzle WE, Bamman MM, Kim JS, Eltoum IA, Elgavish A, Nagy TR
Cancer research 2007 Jul 15;67(14):6612-8

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Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis.

Cohen HY, Lavu S, Bitterman KJ, Hekking B, Imahiyerobo TA, Miller C, Frye R, Ploegh H, Kessler BM, Sinclair DA
Molecular cell 2004 Mar 12;13(5):627-38

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Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase.

Yeung F, Hoberg JE, Ramsey CS, Keller MD, Jones DR, Frye RA, Mayo MW
The EMBO journal 2004 Jun 16;23(12):2369-80

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Mammalian SIRT1 represses forkhead transcription factors.

Motta MC, Divecha N, Lemieux M, Kamel C, Chen D, Gu W, Bultsma Y, McBurney M, Guarente L
Cell 2004 Feb 20;116(4):551-63