AGFG2

This gene is a member of the HIV-1 Rev binding protein (HRB) family and encodes a protein with one Arf-GAP zinc finger domain, several phe-gly (FG) motifs, and four asn-pro-phe (NPF) motifs. This protein interacts with Eps15 homology (EH) domains and plays a role in the Rev export pathway, which mediates the nucleocytoplasmic transfer of proteins and RNAs. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Feb 2013]

Description

ArfGAP with FG repeats 2

Tissue specificity

Tissue enriched (salivary gland)

Subcell location

Nucleoplasm, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

7 (100539203 - 100568220)

Ensembl ID

ENSG00000106351  (ver. 103.38)

Orthologs

Mouse Agfg2: ENSMUSG00000029722

UniProt

O95081

neXtProt

NX_O95081

Human splice variants
Mouse splice variants

Protein structure