Antibody data
- Antibody Data
- Antigen structure
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- Comments [0]
- Validations
- Western blot [1]
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- Product number
- BS60932 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- CD247 polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- A synthetic peptide corresponding to residues in Human CD247.
- Description
- The T cell antigen receptor (TCR) recognizes foreign antigens and translates such recognition events into intracellular signals that elicit a change in the cell from a dormant to an activated state. Much of this signaling process can be attributed to a multisubunit complex of proteins that associates directly with the TCR. This complex has been designated CD3 (cluster of differentiation 3). It is composed of five invariant polypeptide chains that associate to form three dimers: a heterodimer of gamma and epsilon chains (ÎÛ÷), a heterodimer of delta and epsilon chains (?÷) and a homodimer of two zeta chains (øø) or a heterodimer of zeta and eta chains (ø»Ò). The ø and »Ò chains are encoded by the same gene but differ in their carboxyl-terminal ends due to an alternative splicing event. The ÎÛ, ÷ and Ñ´ chains each contain a single copy of a conserved immunoreceptor tyrosine-based activation motif (ITAM). In contrast, the ø chain contains three consecutive copies of the same motif. Phosphorylated ITAMs act as docking sites for protein kinases such as ZAP-70 and Syk and are also capable of regulating their kinase activity. The crystal structure of the ZAP-70 SH2 domains bound to the ø chain ITAMs has been solved.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
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- Experimental details
- Western blot (WB) analysis of CD247 pAb at 1:500 dilutionLine1:Jurkat whole cell lysateLine2:PC12 whole cell lysateLine3:sp20 whole cell lysate