BS60932

antibody from Bioworld Technology, Inc
Targeting: CD247 CD3H, CD3Q, CD3Z
Provider product page for BS60932

Antibody data

Product number
BS60932 - Provider product page
Provider
Bioworld Technology, Inc
Product name
CD247 polyclonal antibody
Antibody type
Polyclonal
Antigen
A synthetic peptide corresponding to residues in Human CD247.
Description
The T cell antigen receptor (TCR) recognizes foreign antigens and translates such recognition events into intracellular signals that elicit a change in the cell from a dormant to an activated state. Much of this signaling process can be attributed to a multisubunit complex of proteins that associates directly with the TCR. This complex has been designated CD3 (cluster of differentiation 3). It is composed of five invariant polypeptide chains that associate to form three dimers: a heterodimer of gamma and epsilon chains (Îۚ÷), a heterodimer of delta and epsilon chains (?š÷) and a homodimer of two zeta chains (šøšø) or a heterodimer of zeta and eta chains (šø»Ò). The šø and »Ò chains are encoded by the same gene but differ in their carboxyl-terminal ends due to an alternative splicing event. The ÎÛ, š÷ and Ñ´ chains each contain a single copy of a conserved immunoreceptor tyrosine-based activation motif (ITAM). In contrast, the šø chain contains three consecutive copies of the same motif. Phosphorylated ITAMs act as docking sites for protein kinases such as ZAP-70 and Syk and are also capable of regulating their kinase activity. The crystal structure of the ZAP-70 SH2 domains bound to the šø chain ITAMs has been solved.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
CD247 protein structure - BS60932 shown in red.