CD247

The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Description

CD247 molecule

Tissue specificity

Group enriched (bone marrow, lymphoid tissue)

Predicted location

Membrane

Protein family

CD markers
Disease related genes
FDA approved drug targets
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transporters

Chromosome

1 (167430640 - 167518610)

Ensembl ID

ENSG00000198821  (ver. 103.38)

Orthologs

Mouse Cd247: ENSMUSG00000005763

UniProt

P20963

neXtProt

NX_P20963

Human splice variants
Mouse splice variants

Protein structure