Antibody data
- Antibody Data
- Antigen structure
- References [332]
- Comments [0]
- Validations
- Flow cytometry [1]
- Other assay [27]
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- Product number
- 14-0037-82 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- CD3 Monoclonal Antibody (OKT3), eBioscience™
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- Description: The OKT3 monoclonal antibody reacts with an epitope on the epsilon-subunit within the human CD3 complex. The OKT3 antibody has been reported to have potent immunosuppressive properties in vivo and has been proven effective in the treatment of renal, heart and liver allograft rejection. The CD3 subunits, gamma, delta, and epsilon chains, are required for proper assembly, trafficking and surface expression of the TCR complex. CD3 is expressed by thymocytes in a developmentally regulated manner and by all mature T cells. Crosslinking of TCR initiates an intracellular biochemical pathway resulting in cellular activation and proliferation.
- Antibody clone number
- OKT3
- Concentration
- 0.5 mg/mL
Submitted references Dynamic S-acylation of the ER-resident protein stromal interaction molecule 1 (STIM1) is required for store-operated Ca(2+) entry.
Cavβ1 regulates T cell expansion and apoptosis independently of voltage-gated Ca(2+) channel function.
CD40 Pathway and IL-2 Expression Mediate the Differential Outcome of Colorectal Cancer Patients with Different CSF1R c.1085 Genotypes.
T cell receptor-dependent S-acylation of ZAP-70 controls activation of T cells.
Engineering advanced logic and distributed computing in human CAR immune cells.
Increased Protein Stability and Interleukin-2 Production of a LAT(G131D) Variant With Possible Implications for T Cell Anergy.
Repositioning liothyronine for cancer immunotherapy by blocking the interaction of immune checkpoint TIGIT/PVR.
TGF-β Enhances the Anti-inflammatory Effect of Tumor- Infiltrating CD33+11b+HLA-DR Myeloid-Derived Suppressor Cells in Gastric Cancer: A Possible Relation to MicroRNA-494.
TIGIT is upregulated by HIV-1 infection and marks a highly functional adaptive and mature subset of natural killer cells.
Electroporation of NKG2D RNA CAR Improves Vγ9Vδ2 T Cell Responses against Human Solid Tumor Xenografts.
Human pDCs Are Superior to cDC2s in Attracting Cytolytic Lymphocytes in Melanoma Patients Receiving DC Vaccination.
Activation of Human Vδ2(+) γδ T Cells by Staphylococcus aureus Promotes Enhanced Anti-Staphylococcal Adaptive Immunity.
Evaluation of Single-Cell Cytokine Secretion and Cell-Cell Interactions with a Hierarchical Loading Microwell Chip.
The multi-functionality of N-809, a novel fusion protein encompassing anti-PD-L1 and the IL-15 superagonist fusion complex.
Peripheral blood CD4+ T cell populations by CD25 and Foxp3 expression as a potential biomarker: reflecting inflammatory activity in chronic obstructive pulmonary disease.
Targeting immunotherapy for bladder cancer by using anti-CD3 × CD155 bispecific antibody.
Stimulation of Mononuclear Cells Through Toll-Like Receptor 9 Induces Release of Microvesicles Expressing Double-Stranded DNA and Galectin 3-Binding Protein in an Interferon-α-Dependent Manner.
Immunosuppression by monocytic myeloid-derived suppressor cells in patients with pancreatic ductal carcinoma is orchestrated by STAT3.
Intrahepatic macrophage populations in the pathophysiology of primary sclerosing cholangitis.
Synthetic TRuC receptors engaging the complete T cell receptor for potent anti-tumor response.
Suppression of R5-type of HIV-1 in CD4(+) NKT cells by Vδ1(+) T cells activated by flavonoid glycosides, hesperidin and linarin.
Antisense oligonucleotide targeting CD39 improves anti-tumor T cell immunity.
Adaptive plasticity of IL-10(+) and IL-35(+) T(reg) cells cooperatively promotes tumor T cell exhaustion.
Efficient identification of neoantigen-specific T-cell responses in advanced human ovarian cancer.
NK cells specifically TCR-dressed to kill cancer cells.
Leptin induces TNFα-dependent inflammation in acquired generalized lipodystrophy and combined Crohn's disease.
Immunodeficiency and EBV-induced lymphoproliferation caused by 4-1BB deficiency.
Cutting Edge: IL-17B Uses IL-17RA and IL-17RB to Induce Type 2 Inflammation from Human Lymphocytes.
Filamin A Phosphorylation at Serine 2152 by the Serine/Threonine Kinase Ndr2 Controls TCR-Induced LFA-1 Activation in T Cells.
A Stretch of Negatively Charged Amino Acids of Linker for Activation of T-Cell Adaptor Has a Dual Role in T-Cell Antigen Receptor Intracellular Signaling.
Combined Immunodeficiency in Patients With Trichohepatoenteric Syndrome.
Choice of costimulatory domains and of cytokines determines CAR T-cell activity in neuroblastoma.
Improved migration of tumor ascites lymphocytes to ovarian cancer microenvironment by CXCR2 transduction.
The inhibitory checkpoint, PD-L2, is a target for effector T cells: Novel possibilities for immune therapy.
Site-specific PEGylation of an anti-CEA/CD3 bispecific antibody improves its antitumor efficacy.
A mutation in the progesterone receptor predisposes to HEV infection in HIV-positive patients.
Multiple Homozygous Variants in the STING-Encoding TMEM173 Gene in HIV Long-Term Nonprogressors.
Functional and phenotypical analysis of IL-6-secreting CD4(+) T cells in human adipose tissue.
Targeting bladder cancer using activated T cells armed with bispecific antibodies.
Adoptive Immunotherapy Using PRAME-Specific T Cells in Medulloblastoma.
CD226 opposes TIGIT to disrupt Tregs in melanoma.
TCF1 expression marks self-renewing human CD8(+) T cells.
STAT5B: A Differential Regulator of the Life and Death of CD4(+) Effector Memory T Cells.
Cytokine-induced alterations of BAMBI mediate the reciprocal regulation of human Th17/Treg cells in response to cigarette smoke extract.
"Waltz" of Cell Membrane-Coated Nanoparticles on Lipid Bilayers: Tracking Single Particle Rotation in Ligand-Receptor Binding.
Discovery and preclinical characterization of the antagonist anti-PD-L1 monoclonal antibody LY3300054.
An Analysis of Trafficking Receptors Shows that CD44 and P-Selectin Glycoprotein Ligand-1 Collectively Control the Migration of Activated Human T-Cells.
Dexamethasone and Monophosphoryl Lipid A Induce a Distinctive Profile on Monocyte-Derived Dendritic Cells through Transcriptional Modulation of Genes Associated With Essential Processes of the Immune Response.
Th2/1 Hybrid Cells Occurring in Murine and Human Strongyloidiasis Share Effector Functions of Th1 Cells.
Expression and role of interleukin-9 in Vogt-Koyanagi-Harada disease.
Functional characterization of T-cells from palatine tonsils in patients with chronic tonsillitis.
Constitutive and activation-dependent phosphorylation of lymphocyte phosphatase-associated phosphoprotein (LPAP).
A human tissue-based functional assay platform to evaluate the immune function impact of small molecule inhibitors that target the immune system.
Differential immunomodulation in human monocytes versus macrophages by filarial cystatin.
Src-family kinases negatively regulate NFAT signaling in resting human T cells.
Restimulation-induced T-cell death through NTB-A/SAP signaling pathway is impaired in tuberculosis patients with depressed immune responses.
Role of regulatory T cells in acute myeloid leukemia patients undergoing relapse-preventive immunotherapy.
Activity of lenalidomide in mantle cell lymphoma can be explained by NK cell-mediated cytotoxicity.
HLA-B*14:02-Restricted Env-Specific CD8(+) T-Cell Activity Has Highly Potent Antiviral Efficacy Associated with Immune Control of HIV Infection.
Antigen presentation profiling reveals recognition of lymphoma immunoglobulin neoantigens.
Clonal selection in the human Vδ1 T cell repertoire indicates γδ TCR-dependent adaptive immune surveillance.
A 3D microfluidic model for preclinical evaluation of TCR-engineered T cells against solid tumors.
FcγRIIIa Signaling Modulates Endosomal TLR Responses in Human CD4(+) T Cells.
Prolonged immunomodulation in inflammatory arthritis using the selective Kv1.3 channel blocker HsTX1[R14A] and its PEGylated analog.
5T4-specific chimeric antigen receptor modification promotes the immune efficacy of cytokine-induced killer cells against nasopharyngeal carcinoma stem cell-like cells.
CXCL4 Exposure Potentiates TLR-Driven Polarization of Human Monocyte-Derived Dendritic Cells and Increases Stimulation of T Cells.
A cycle of Zap70 kinase activation and release from the TCR amplifies and disperses antigenic stimuli.
A Proteomic Survey Indicates Sortilin as a Secondary Substrate of the ER Translocation Inhibitor Cyclotriazadisulfonamide (CADA).
Hepatitis C virus infection inhibits a Src-kinase regulatory phosphatase and reduces T cell activation in vivo.
Sorting nexin 27 interactome in T-lymphocytes identifies zona occludens-2 dynamic redistribution at the immune synapse.
Down-regulation of microRNA-451a facilitates the activation and proliferation of CD4(+) T cells by targeting Myc in patients with dilated cardiomyopathy.
NOD1 modulates IL-10 signalling in human dendritic cells.
D120 and K152 within the PH Domain of T Cell Adapter SKAP55 Regulate Plasma Membrane Targeting of SKAP55 and LFA-1 Affinity Modulation in Human T Lymphocytes.
Inhibiting Oxidative Phosphorylation In Vivo Restrains Th17 Effector Responses and Ameliorates Murine Colitis.
CD16(+) Monocyte Subset Was Enriched and Functionally Exacerbated in Driving T-Cell Activation and B-Cell Response in Systemic Lupus Erythematosus.
Umbilical Cord-Derived Mesenchymal Stem Cells Suppress Autophagy of T Cells in Patients with Systemic Lupus Erythematosus via Transfer of Mitochondria.
Follicular Lymphoma Tregs Have a Distinct Transcription Profile Impacting Their Migration and Retention in the Malignant Lymph Node.
Validation and Optimization of an Ex Vivo Assay of Intestinal Mucosal Biopsies in Crohn's Disease: Reflects Inflammation and Drug Effects.
Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination.
Differential effects of α4β7 and GPR15 on homing of effector and regulatory T cells from patients with UC to the inflamed gut in vivo.
A DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeleton.
HCV core protein inhibits polarization and activity of both M1 and M2 macrophages through the TLR2 signaling pathway.
Rational design of a Kv1.3 channel-blocking antibody as a selective immunosuppressant.
T-lymphocyte passive deformation is controlled by unfolding of membrane surface reservoirs.
Functional differences in hepatitis C virus nonstructural (NS) 3/4A- and 5A-specific T cell responses.
Increased Th17 cells and IL-17A exist in patients with B cell acute lymphoblastic leukemia and promote proliferation and resistance to daunorubicin through activation of Akt signaling.
IL15 Agonists Overcome the Immunosuppressive Effects of MEK Inhibitors.
Obesity decreases B cell responses in young and elderly individuals.
Expression of the galectin-9-Tim-3 pathway in glioma tissues is associated with the clinical manifestations of glioma.
The adhesion molecule PECAM-1 enhances the TGF-β-mediated inhibition of T cell function.
IL-7 Induces SAMHD1 Phosphorylation in CD4+ T Lymphocytes, Improving Early Steps of HIV-1 Life Cycle.
Control of Foxp3 stability through modulation of TET activity.
Combining FoxP3 and Helios with GARP/LAP markers can identify expanded Treg subsets in cancer patients.
Human naïve regulatory T-cells feature high steady-state turnover and are maintained by IL-7.
Implication of combined PD-L1/PD-1 blockade with cytokine-induced killer cells as a synergistic immunotherapy for gastrointestinal cancer.
A Small Molecule, Which Competes with MAdCAM-1, Activates Integrin α4β7 and Fails to Prevent Mucosal Transmission of SHIV-SF162P3.
Human Galectin-9 Is a Potent Mediator of HIV Transcription and Reactivation.
Receptor-Targeted Nipah Virus Glycoproteins Improve Cell-Type Selective Gene Delivery and Reveal a Preference for Membrane-Proximal Cell Attachment.
Golgi self-correction generates bioequivalent glycans to preserve cellular homeostasis.
Granulocyte colony-stimulating factor impairs CD8(+) T cell functionality by interfering with central activation elements.
Calcium influx through CRAC channels controls actin organization and dynamics at the immune synapse.
Treg activation defect in type 1 diabetes: correction with TNFR2 agonism.
Patients with MS under daclizumab therapy mount normal immune responses to influenza vaccination.
Monocyte-derived inflammatory Langerhans cells and dermal dendritic cells mediate psoriasis-like inflammation.
Genetically modified human CD4(+) T cells can be evaluated in vivo without lethal graft-versus-host disease.
MiRNA-22 inhibits oncogene galectin-1 in hepatocellular carcinoma.
Human TRAV1-2-negative MR1-restricted T cells detect S. pyogenes and alternatives to MAIT riboflavin-based antigens.
Synergistic COX2 Induction by IFNγ and TNFα Self-Limits Type-1 Immunity in the Human Tumor Microenvironment.
The Macrophage Galactose-Type C-Type Lectin (MGL) Modulates Regulatory T Cell Functions.
Inflammatory IL-15 is required for optimal memory T cell responses.
Conserved Motifs within Hepatitis C Virus Envelope (E2) RNA and Protein Independently Inhibit T Cell Activation.
Direct tumor recognition by a human CD4(+) T-cell subset potently mediates tumor growth inhibition and orchestrates anti-tumor immune responses.
In-vitro Optimization of Nanoparticle-Cell Labeling Protocols for In-vivo Cell Tracking Applications.
The human complement inhibitor Sushi Domain-Containing Protein 4 (SUSD4) expression in tumor cells and infiltrating T cells is associated with better prognosis of breast cancer patients.
Molecular difference between WASP and N-WASP critical for chemotaxis of T-cells towards SDF-1α.
Dual-Affinity Re-Targeting proteins direct T cell-mediated cytolysis of latently HIV-infected cells.
Increased Levels of Macrophage Inflammatory Proteins Result in Resistance to R5-Tropic HIV-1 in a Subset of Elite Controllers.
Broadening the repertoire of melanoma-associated T-cell epitopes.
Adenosine Receptor 2A Blockade Increases the Efficacy of Anti-PD-1 through Enhanced Antitumor T-cell Responses.
TIGIT and PD-1 impair tumor antigen-specific CD8⁺ T cells in melanoma patients.
A novel antibody-drug conjugate targeting SAIL for the treatment of hematologic malignancies.
The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway.
TLR5 Ligand-Secreting T Cells Reshape the Tumor Microenvironment and Enhance Antitumor Activity.
IL-12 secreting tumor-targeted chimeric antigen receptor T cells eradicate ovarian tumors in vivo.
c-CBL E3 ubiquitin ligase is overexpressed in cutaneous T-cell lymphoma: its inhibition promotes activation-induced cell death.
Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathway.
Mutations in early follicular lymphoma progenitors are associated with suppressed antigen presentation.
Activated human valvular interstitial cells sustain interleukin-17 production to recruit neutrophils in infective endocarditis.
PD-1+Tim-3+ CD8+ T Lymphocytes Display Varied Degrees of Functional Exhaustion in Patients with Regionally Metastatic Differentiated Thyroid Cancer.
South African HIV-1 subtype C transmitted variants with a specific V2 motif show higher dependence on α4β7 for replication.
Fatal autoimmunity in mice reconstituted with human hematopoietic stem cells encoding defective FOXP3.
Mature cystic fibrosis airway neutrophils suppress T cell function: evidence for a role of arginase 1 but not programmed death-ligand 1.
Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53.
Autoregulatory function of interleukin-10-producing pre-naïve B cells is defective in systemic lupus erythematosus.
Human NK cell repertoire diversity reflects immune experience and correlates with viral susceptibility.
Chemotherapy-Derived Inflammatory Responses Accelerate the Formation of Immunosuppressive Myeloid Cells in the Tissue Microenvironment of Human Pancreatic Cancer.
Integrative analysis of T cell motility from multi-channel microscopy data using TIAM.
Tryptophan 2,3-dioxygenase (TDO)-reactive T cells differ in their functional characteristics in health and cancer.
Ex vivo expansion of human T cells for adoptive immunotherapy using the novel Xeno-free CTS Immune Cell Serum Replacement.
Towards programming immune tolerance through geometric manipulation of phosphatidylserine.
Bone marrow-derived mesenchymal stromal cells harness purinergenic signaling to tolerize human Th1 cells in vivo.
Blocking GluR2-GAPDH ameliorates experimental autoimmune encephalomyelitis.
Increased presence of FOXP3+ regulatory T cells in inflamed muscle of patients with active juvenile dermatomyositis compared to peripheral blood.
Dendritic cells loaded with pancreatic Cancer Stem Cells (CSCs) lysates induce antitumor immune killing effect in vitro.
TL1A induces TCR independent IL-6 and TNF-α production and growth of PLZF⁺ leukocytes.
The generation of induced pluripotent stem cells for macular degeneration as a drug screening platform: identification of curcumin as a protective agent for retinal pigment epithelial cells against oxidative stress.
Spontaneous presence of FOXO3-specific T cells in cancer patients.
Exploring T cell reactivity to gliadin in young children with newly diagnosed celiac disease.
A truncated human NKG2D splice isoform negatively regulates NKG2D-mediated function.
Activation and propagation of tumor-infiltrating lymphocytes on clinical-grade designer artificial antigen-presenting cells for adoptive immunotherapy of melanoma.
An NCR1-based chimeric receptor endows T-cells with multiple anti-tumor specificities.
Akt-dependent enhanced migratory capacity of Th17 cells from children with lupus nephritis.
Exposure to a histone deacetylase inhibitor has detrimental effects on human lymphocyte viability and function.
NKG2D- and CD28-mediated costimulation regulate CD8+ T cell chemotaxis through different mechanisms: the role of Cdc42/N-WASp.
Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4(CRBN.).
High CTLA-4 expression on Th17 cells results in increased sensitivity to CTLA-4 coinhibition and resistance to belatacept.
Non-overlapping functions of Nck1 and Nck2 adaptor proteins in T cell activation.
Genuine Immunomodulation With dSLIM.
Adenosine triphosphate acts as a paracrine signaling molecule to reduce the motility of T cells.
Bioengineering T cells to target carbohydrate to treat opportunistic fungal infection.
N-glycosylation of asparagine 8 regulates surface expression of major histocompatibility complex class I chain-related protein A (MICA) alleles dependent on threonine 24.
Human Th2 but not Th9 cells release IL-31 in a STAT6/NF-κB-dependent way.
Prevailing role of contact guidance in intrastromal T-cell trapping in human pancreatic cancer.
Development of virus-specific CD4+ and CD8+ regulatory T cells induced by human herpesvirus 6 infection.
Comparative transcriptional and functional profiling defines conserved programs of intestinal DC differentiation in humans and mice.
A dual-targeting triplebody mediates preferential redirected lysis of antigen double-positive over single-positive leukemic cells.
Long-lasting disease stabilization in the absence of toxicity in metastatic lung cancer patients vaccinated with an epitope derived from indoleamine 2,3 dioxygenase.
Inhibition of the immunoproteasome ameliorates experimental autoimmune encephalomyelitis.
Building and optimizing a virus-specific T cell receptor library for targeted immunotherapy in viral infections.
Dual-specificity phosphatase 14 (DUSP14/MKP6) negatively regulates TCR signaling by inhibiting TAB1 activation.
High IP-10 levels decrease T cell function in HIV-1-infected individuals on ART.
Bispecific anti-CD3 x anti-HER2 antibody mediates T cell cytolytic activity to HER2-positive colorectal cancer in vitro and in vivo.
HIF-1α- and hypoxia-dependent immune responses in human CD4+CD25high T cells and T helper 17 cells.
Recombinant IgG2a Fc (M045) multimers effectively suppress experimental autoimmune myasthenia gravis.
Histone deacetylase inhibitors impair the elimination of HIV-infected cells by cytotoxic T-lymphocytes.
Calmodulin and PI(3,4,5)P₃ cooperatively bind to the Itk pleckstrin homology domain to promote efficient calcium signaling and IL-17A production.
Wiskott-Aldrich Syndrome causing mutation, Pro373Ser restricts conformational changes essential for WASP activity in T-cells.
CD4CD8αα lymphocytes, a novel human regulatory T cell subset induced by colonic bacteria and deficient in patients with inflammatory bowel disease.
Alternative capture of noncoding RNAs or protein-coding genes by herpesviruses to alter host T cell function.
T-cell responses to oncogenic merkel cell polyomavirus proteins distinguish patients with merkel cell carcinoma from healthy donors.
Novel CD47: SIRPα dependent mechanism for the activation of STAT3 in antigen-presenting cell.
HER2 as a promising target for cytotoxicity T cells in human melanoma therapy.
Cyclotides Suppress Human T-Lymphocyte Proliferation by an Interleukin 2-Dependent Mechanism.
Activated human nasal epithelial cells modulate specific antibody response against bacterial or viral antigens.
Impaired functionality of antiviral T cells in G-CSF mobilized stem cell donors: implications for the selection of CTL donor.
IL-4 confers resistance to IL-27-mediated suppression on CD4+ T cells by impairing signal transducer and activator of transcription 1 signaling.
IL-2-inducible T-cell kinase modulates TH2-mediated allergic airway inflammation by suppressing IFN-γ in naive CD4+ T cells.
Intercellular adhesion molecule 1 mediates migration of Th1 and Th17 cells across human retinal vascular endothelium.
Human T cells engineered to express a programmed death 1/28 costimulatory retargeting molecule display enhanced antitumor activity.
LAT1 is a critical transporter of essential amino acids for immune reactions in activated human T cells.
Effects of conventional therapeutic interventions on the number and function of regulatory T cells.
CD137L-stimulated dendritic cells are more potent than conventional dendritic cells at eliciting cytotoxic T-cell responses.
CD70-CD27 ligation between neural stem cells and CD4+ T cells induces Fas-FasL-mediated T-cell death.
Fine-tuning of regulatory T cell function: the role of calcium signals and naive regulatory T cells for regulatory T cell deficiency in multiple sclerosis.
Peptide library-based evaluation of T-cell receptor breadth detects defects in global and regulatory activation in human immunologic diseases.
Human neonatal naive CD4+ T cells have enhanced activation-dependent signaling regulated by the microRNA miR-181a.
The zinc-binding region of IL-2 inducible T cell kinase (Itk) is required for interaction with Gα13 and activation of serum response factor.
Adipocyte-derived lipids modulate CD4+ T-cell function.
Methylation of FOXP3 in regulatory T cells is related to the severity of coronary artery disease.
GB virus C particles inhibit T cell activation via envelope E2 protein-mediated inhibition of TCR signaling.
HHLA2 is a member of the B7 family and inhibits human CD4 and CD8 T-cell function.
Mesenchymal stem cells from periapical lesions modulate differentiation and functional properties of monocyte-derived dendritic cells.
Up-regulation of proliferative and migratory genes in regulatory T cells from patients with metastatic castration-resistant prostate cancer.
Phase I trial of a multi-epitope-pulsed dendritic cell vaccine for patients with newly diagnosed glioblastoma.
Enhanced function of redirected human T cells expressing linker for activation of T cells that is resistant to ubiquitylation.
Nuclear translocation of MEK1 triggers a complex T cell response through the corepressor silencing mediator of retinoid and thyroid hormone receptor.
Anti-KIT designer T cells for the treatment of gastrointestinal stromal tumor.
Beta-lactam antibiotics modulate T-cell functions and gene expression via covalent binding to cellular albumin.
LINE-1 retrotransposable element DNA accumulates in HIV-1-infected cells.
Anti-tumor necrosis factor α targets protein kinase B/c-Akt-induced resistance of effector cells to suppression in juvenile idiopathic arthritis.
B7-H4Ig inhibits mouse and human T-cell function and treats EAE via IL-10/Treg-dependent mechanisms.
Activation of the transcriptional function of the NF-κB protein c-Rel by O-GlcNAc glycosylation.
Toward eliminating HLA class I expression to generate universal cells from allogeneic donors.
Soluble GARP has potent antiinflammatory and immunomodulatory impact on human CD4⁺ T cells.
A practical approach to immunotherapy of hepatocellular carcinoma using T cells redirected against hepatitis B virus.
Hypomorphic Janus kinase 3 mutations result in a spectrum of immune defects, including partial maternal T-cell engraftment.
Low-dose interleukin-2 therapy restores regulatory T cell homeostasis in patients with chronic graft-versus-host disease.
Transmitted/founder and chronic subtype C HIV-1 use CD4 and CCR5 receptors with equal efficiency and are not inhibited by blocking the integrin α4β7.
Biochemical and functional studies of lymphoid-specific tyrosine phosphatase (Lyp) variants S201F and R266W.
Global activation of CD8+ cytotoxic T lymphocytes correlates with an impairment in regulatory T cells in patients with generalized vitiligo.
Cannabinoid receptor 2-mediated attenuation of CXCR4-tropic HIV infection in primary CD4+ T cells.
Apoptotic effects of antilymphocyte globulins on human pro-inflammatory CD4+CD28- T-cells.
HSP70 enhances immunosuppressive function of CD4(+)CD25(+)FoxP3(+) T regulatory cells and cytotoxicity in CD4(+)CD25(-) T cells.
A cancer vaccine induces expansion of NY-ESO-1-specific regulatory T cells in patients with advanced melanoma.
Fermented mistletoe extract as a multimodal antitumoral agent in gliomas.
Inhibition of activation induced CD154 on CD4+ CD25- cells: a valid surrogate for human Treg suppressor function.
Engagement of T-cell antigen receptor and CD4/CD8 co-receptors induces prolonged STAT activation through autocrine/paracrine stimulation in human primary T cells.
Lymphocyte-polarized dendritic cells are highly effective in inducing tumor-specific CTLs.
Novel humanized and highly efficient bispecific antibodies mediate killing of prostate stem cell antigen-expressing tumor cells by CD8+ and CD4+ T cells.
GB virus C envelope protein E2 inhibits TCR-induced IL-2 production and alters IL-2-signaling pathways.
Cytokine secretion by CD4+ T cells at the immunological synapse requires Cdc42-dependent local actin remodeling but not microtubule organizing center polarity.
Expression and isotopic labelling of the potassium channel blocker ShK toxin as a thioredoxin fusion protein in bacteria.
Polycomb antagonizes p300/CREB-binding protein-associated factor to silence FOXP3 in a Kruppel-like factor-dependent manner.
TCR-redirected human T cells inhibit hepatitis C virus replication: hepatotoxic potential is linked to antigen specificity and functional avidity.
K12/SECTM1, an interferon-γ regulated molecule, synergizes with CD28 to costimulate human T cell proliferation.
Emergence of peripheral CD3+CD56+ cytokine-induced killer cell in HIV-1-infected Chinese children.
DNGR-1 is a specific and universal marker of mouse and human Batf3-dependent dendritic cells in lymphoid and nonlymphoid tissues.
A foundation for universal T-cell based immunotherapy: T cells engineered to express a CD19-specific chimeric-antigen-receptor and eliminate expression of endogenous TCR.
A predictive biomimetic model of cytokine release induced by TGN1412 and other therapeutic monoclonal antibodies.
Loss of the signaling adaptor TRAF1 causes CD8+ T cell dysregulation during human and murine chronic infection.
Trogocytosis is a gateway to characterize functional diversity in melanoma-specific CD8+ T cell clones.
Phenotypic complexity of T regulatory subsets in patients with B-chronic lymphocytic leukemia.
Differential mTOR and ERK pathway utilization by effector CD4 T cells suggests combinatorial drug therapy of arthritis.
A mutation in the human Uncoordinated 119 gene impairs TCR signaling and is associated with CD4 lymphopenia.
Do plant cyclotides have potential as immunosuppressant peptides?
Production of TNF-α in macrophages activated by T cells, compared with lipopolysaccharide, uses distinct IL-10-dependent regulatory mechanism.
Blood-derived human iPS cells generate optic vesicle-like structures with the capacity to form retinal laminae and develop synapses.
Licensing virus-specific T cells to secrete the neutrophil attracting chemokine CXCL-8 during hepatitis B virus infection.
Follicular lymphoma tumor-infiltrating T-helper (T(H)) cells have the same polyfunctional potential as normal nodal T(H) cells despite skewed differentiation.
Functional human regulatory T cells fail to control autoimmune inflammation due to PKB/c-akt hyperactivation in effector cells.
Functional gap junctions accumulate at the immunological synapse and contribute to T cell activation.
Enhanced phosphoinositide 3-kinase δ activity is a frequent event in systemic lupus erythematosus that confers resistance to activation-induced T cell death.
Engineering T cells specific for a dominant severe acute respiratory syndrome coronavirus CD8 T cell epitope.
Increased frequency of regulatory T cells accompanies increased immune activation in rectal mucosae of HIV-positive noncontrollers.
Low telomerase activity in CD4+ regulatory T cells in patients with severe chronic GVHD after hematopoietic stem cell transplantation.
A critical role for STAT3 transcription factor signaling in the development and maintenance of human T cell memory.
Atorvastatin upregulates regulatory T cells and reduces clinical disease activity in patients with rheumatoid arthritis.
The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells.
In vitro and in vivo model of a novel immunotherapy approach for chronic lymphocytic leukemia by anti-CD23 chimeric antigen receptor.
Predicting cytotoxic T-cell age from multivariate analysis of static and dynamic biomarkers.
NKG2D receptor regulates human effector T-cell cytokine production.
An HIV-1 gp120 envelope human monoclonal antibody that recognizes a C1 conformational epitope mediates potent antibody-dependent cellular cytotoxicity (ADCC) activity and defines a common ADCC epitope in human HIV-1 serum.
Maturation of human dendritic cells with Saccharomyces cerevisiae (yeast) reduces the number and function of regulatory T cells and enhances the ratio of antigen-specific effectors to regulatory T cells.
Serine residues in the LAT adaptor are essential for TCR-dependent signal transduction.
SHP2 is a target of the immunosuppressant tautomycetin.
Heat shock protein 27 differentiates tolerogenic macrophages that may support human breast cancer progression.
Analysis of circulating regulatory T cells in patients with metastatic prostate cancer pre- versus post-vaccination.
The human cytomegalovirus UL11 protein interacts with the receptor tyrosine phosphatase CD45, resulting in functional paralysis of T cells.
T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice.
Interleukin-2 and regulatory T cells in graft-versus-host disease.
Cofilin-mediated F-actin severing is regulated by the Rap GTPase and controls the cytoskeletal dynamics that drive lymphocyte spreading and BCR microcluster formation.
Engineered artificial antigen presenting cells facilitate direct and efficient expansion of tumor infiltrating lymphocytes.
Protein kinase Ctheta is a specific target for inhibition of the HIV type 1 replication in CD4+ T lymphocytes.
Impairment of regulatory capacity of CD4+CD25+ regulatory T cells mediated by dendritic cell polarization and hyperthyroidism in Graves' disease.
Enhanced suppressive function of regulatory T cells from patients with immune-mediated diseases following successful ex vivo expansion.
PD-1 on immature and PD-1 ligands on migratory human Langerhans cells regulate antigen-presenting cell activity.
CD277 is a negative co-stimulatory molecule universally expressed by ovarian cancer microenvironmental cells.
Inhibition of effector function but not T cell activation and increase in FoxP3 expression in T cells differentiated in the presence of PP14.
Modulation of cell signaling networks after CTLA4 blockade in patients with metastatic melanoma.
NF-kappaB inhibits T-cell activation-induced, p73-dependent cell death by induction of MDM2.
Anaphase-promoting complex/cyclosome-Cdh1 coordinates glycolysis and glutaminolysis with transition to S phase in human T lymphocytes.
Altered regulatory T cell homeostasis in patients with CD4+ lymphopenia following allogeneic hematopoietic stem cell transplantation.
Fas ligand gene expression is directly regulated by stress-inducible heat shock transcription factor-1.
Derivation of induced pluripotent stem cells from human peripheral blood T lymphocytes.
Human tumor antigen-specific helper and regulatory T cells share common epitope specificity but exhibit distinct T cell repertoire.
CD137 ligand signaling induces human monocyte to dendritic cell differentiation.
Adhesion and degranulation promoting adapter protein (ADAP) is a central hub for phosphotyrosine-mediated interactions in T cells.
Effects of nilotinib on regulatory T cells: the dose matters.
Genome-wide analysis of allelic expression imbalance in human primary cells by high-throughput transcriptome resequencing.
Polyfunctional T-cell responses are disrupted by the ovarian cancer ascites environment and only partially restored by clinically relevant cytokines.
Human adenosine deaminase 2 induces differentiation of monocytes into macrophages and stimulates proliferation of T helper cells and macrophages.
T-cell receptor complex is essential for Fas signal transduction.
Role played by the programmed death-1-programmed death ligand pathway during innate immunity against Mycobacterium tuberculosis.
Accumulation of foxp3+ T regulatory cells in draining lymph nodes correlates with disease progression and immune suppression in colorectal cancer patients.
Androgen-regulated expression of arginase 1, arginase 2 and interleukin-8 in human prostate cancer.
A role for the transcription factor Helios in human CD4(+)CD25(+) regulatory T cells.
Selective inhibition of IDO1 effectively regulates mediators of antitumor immunity.
IL-7 and IL-21 are superior to IL-2 and IL-15 in promoting human T cell-mediated rejection of systemic lymphoma in immunodeficient mice.
Human cytomegalovirus elicits fetal gammadelta T cell responses in utero.
Expression of the autoimmune susceptibility gene FcRL3 on human regulatory T cells is associated with dysfunction and high levels of programmed cell death-1.
The adapter protein SLP-76 mediates "outside-in" integrin signaling and function in T cells.
Psychosocial adaptation and cellular immunity in breast cancer patients in the weeks after surgery: An exploratory study.
CD69 gene is differentially regulated in T and B cells by evolutionarily conserved promoter-distal elements.
Phosphorus overload and PTH induce aortic expression of Runx2 in experimental uraemia.
A2A adenosine receptor (AR) activation inhibits pro-inflammatory cytokine production by human CD4+ helper T cells and regulates Helicobacter-induced gastritis and bacterial persistence.
Accumulation of raft lipids in T-cell plasma membrane domains engaged in TCR signalling.
ESAT-6 inhibits production of IFN-gamma by Mycobacterium tuberculosis-responsive human T cells.
Parallel multi-time point cell stimulation and lysis on-chip for studying early signaling events in T cell activation.
Brx mediates the response of lymphocytes to osmotic stress through the activation of NFAT5.
Uncoordinated 119 protein controls trafficking of Lck via the Rab11 endosome and is critical for immunological synapse formation.
A role for human skin-resident T cells in wound healing.
Mature antigen-experienced T helper cells synthesize and secrete the B cell chemoattractant CXCL13 in the inflammatory environment of the rheumatoid joint.
Functional implications of plasma membrane condensation for T cell activation.
Dysfunctional CD4+,CD25+ regulatory T cells in untreated active systemic lupus erythematosus secondary to interferon-alpha-producing antigen-presenting cells.
The blood-brain barrier induces differentiation of migrating monocytes into Th17-polarizing dendritic cells.
Antigen presentation by human microvascular endothelial cells triggers ICAM-1-dependent transendothelial protrusion by, and fractalkine-dependent transendothelial migration of, effector memory CD4+ T cells.
Cell-type-specific tyrosine phosphorylation of the herpes simplex virus tegument protein VP11/12 encoded by gene UL46.
LXR signaling couples sterol metabolism to proliferation in the acquired immune response.
High TCL1 expression and intact T-cell receptor signaling define a hyperproliferative subset of T-cell prolymphocytic leukemia.
Establishment and characterization of a cell based artificial antigen-presenting cell for expansion and activation of CD8+ T cells ex vivo.
Enhanced functionality of CD4+CD25(high)FoxP3+ regulatory T cells in the peripheral blood of patients with prostate cancer.
PILAR is a novel modulator of human T-cell expansion.
HIV-induced type I interferon and tryptophan catabolism drive T cell dysfunction despite phenotypic activation.
The immunomodulatory Pseudomonas aeruginosa signalling molecule N-(3-oxododecanoyl)-L-homoserine lactone enters mammalian cells in an unregulated fashion.
Increased frequencies of CD4+ CD25(high) regulatory T cells in acute dengue infection.
Human IL4I1 is a secreted L-phenylalanine oxidase expressed by mature dendritic cells that inhibits T-lymphocyte proliferation.
General strategy for decoration of enveloped viruses with functionally active lipid-modified cytokines.
Lipid raft targeting of hematopoietic protein tyrosine phosphatase by protein kinase C theta-mediated phosphorylation.
Beta-agonists modulate T-cell functions via direct actions on type 1 and type 2 cells.
C1q and MBL, components of the innate immune system, influence monocyte cytokine expression.
Between adaptive and innate immunity: TLR4-mediated perforin production by CD28null T-helper cells in ankylosing spondylitis.
IL-8 responsiveness defines a subset of CD8 T cells poised to kill.
Kodakandla G, West SJ, Wang Q, Tewari R, Zhu MX, Akimzhanov AM, Boehning D
The Journal of biological chemistry 2022 Sep;298(9):102303
The Journal of biological chemistry 2022 Sep;298(9):102303
Cavβ1 regulates T cell expansion and apoptosis independently of voltage-gated Ca(2+) channel function.
Erdogmus S, Concepcion AR, Yamashita M, Sidhu I, Tao AY, Li W, Rocha PP, Huang B, Garippa R, Lee B, Lee A, Hell JW, Lewis RS, Prakriya M, Feske S
Nature communications 2022 Apr 19;13(1):2033
Nature communications 2022 Apr 19;13(1):2033
CD40 Pathway and IL-2 Expression Mediate the Differential Outcome of Colorectal Cancer Patients with Different CSF1R c.1085 Genotypes.
Yeh YM, Lin PC, Su WC, Shen MR
International journal of molecular sciences 2021 Nov 22;22(22)
International journal of molecular sciences 2021 Nov 22;22(22)
T cell receptor-dependent S-acylation of ZAP-70 controls activation of T cells.
Tewari R, Shayahati B, Fan Y, Akimzhanov AM
The Journal of biological chemistry 2021 Jan-Jun;296:100311
The Journal of biological chemistry 2021 Jan-Jun;296:100311
Engineering advanced logic and distributed computing in human CAR immune cells.
Cho JH, Okuma A, Sofjan K, Lee S, Collins JJ, Wong WW
Nature communications 2021 Feb 4;12(1):792
Nature communications 2021 Feb 4;12(1):792
Increased Protein Stability and Interleukin-2 Production of a LAT(G131D) Variant With Possible Implications for T Cell Anergy.
Arbulo-Echevarria MM, Vico-Barranco I, Narbona-Sánchez I, García-Cózar F, Miazek A, Aguado E
Frontiers in cell and developmental biology 2020;8:561503
Frontiers in cell and developmental biology 2020;8:561503
Repositioning liothyronine for cancer immunotherapy by blocking the interaction of immune checkpoint TIGIT/PVR.
Zhou X, Du J, Wang H, Chen C, Jiao L, Cheng X, Zhou X, Chen S, Gou S, Zhao W, Zhai W, Chen J, Gao Y
Cell communication and signaling : CCS 2020 Sep 7;18(1):142
Cell communication and signaling : CCS 2020 Sep 7;18(1):142
TGF-β Enhances the Anti-inflammatory Effect of Tumor- Infiltrating CD33+11b+HLA-DR Myeloid-Derived Suppressor Cells in Gastric Cancer: A Possible Relation to MicroRNA-494.
Moaaz M, Lotfy H, Elsherbini B, Motawea MA, Fadali G
Asian Pacific journal of cancer prevention : APJCP 2020 Nov 1;21(11):3393-3403
Asian Pacific journal of cancer prevention : APJCP 2020 Nov 1;21(11):3393-3403
TIGIT is upregulated by HIV-1 infection and marks a highly functional adaptive and mature subset of natural killer cells.
Vendrame E, Seiler C, Ranganath T, Zhao NQ, Vergara R, Alary M, Labbé AC, Guédou F, Poudrier J, Holmes S, Roger M, Blish CA
AIDS (London, England) 2020 May 1;34(6):801-813
AIDS (London, England) 2020 May 1;34(6):801-813
Electroporation of NKG2D RNA CAR Improves Vγ9Vδ2 T Cell Responses against Human Solid Tumor Xenografts.
Ang WX, Ng YY, Xiao L, Chen C, Li Z, Chi Z, Tay JC, Tan WK, Zeng J, Toh HC, Wang S
Molecular therapy oncolytics 2020 Jun 26;17:421-430
Molecular therapy oncolytics 2020 Jun 26;17:421-430
Human pDCs Are Superior to cDC2s in Attracting Cytolytic Lymphocytes in Melanoma Patients Receiving DC Vaccination.
van Beek JJP, Flórez-Grau G, Gorris MAJ, Mathan TSM, Schreibelt G, Bol KF, Textor J, de Vries IJM
Cell reports 2020 Jan 28;30(4):1027-1038.e4
Cell reports 2020 Jan 28;30(4):1027-1038.e4
Activation of Human Vδ2(+) γδ T Cells by Staphylococcus aureus Promotes Enhanced Anti-Staphylococcal Adaptive Immunity.
Cooper AJR, Lalor SJ, McLoughlin RM
Journal of immunology (Baltimore, Md. : 1950) 2020 Aug 15;205(4):1039-1049
Journal of immunology (Baltimore, Md. : 1950) 2020 Aug 15;205(4):1039-1049
Evaluation of Single-Cell Cytokine Secretion and Cell-Cell Interactions with a Hierarchical Loading Microwell Chip.
Zhou Y, Shao N, Bessa de Castro R, Zhang P, Ma Y, Liu X, Huang F, Wang RF, Qin L
Cell reports 2020 Apr 28;31(4):107574
Cell reports 2020 Apr 28;31(4):107574
The multi-functionality of N-809, a novel fusion protein encompassing anti-PD-L1 and the IL-15 superagonist fusion complex.
Jochems C, Tritsch SR, Knudson KM, Gameiro SR, Smalley Rumfield C, Pellom ST, Morillon YM, Newman R, Marcus W, Szeto C, Rabizadeh S, Wong HC, Soon-Shiong P, Schlom J
Oncoimmunology 2019;8(2):e1532764
Oncoimmunology 2019;8(2):e1532764
Peripheral blood CD4+ T cell populations by CD25 and Foxp3 expression as a potential biomarker: reflecting inflammatory activity in chronic obstructive pulmonary disease.
Meng ZJ, Wu JH, Zhou M, Sun SW, Miao SY, Han HL, Chen L, Xiong XZ
International journal of chronic obstructive pulmonary disease 2019;14:1669-1680
International journal of chronic obstructive pulmonary disease 2019;14:1669-1680
Targeting immunotherapy for bladder cancer by using anti-CD3 × CD155 bispecific antibody.
Ma W, Ma J, Lei T, Zhao M, Zhang M
Journal of Cancer 2019;10(21):5153-5161
Journal of Cancer 2019;10(21):5153-5161
Stimulation of Mononuclear Cells Through Toll-Like Receptor 9 Induces Release of Microvesicles Expressing Double-Stranded DNA and Galectin 3-Binding Protein in an Interferon-α-Dependent Manner.
Rasmussen NS, Nielsen CT, Jacobsen S, Nielsen CH
Frontiers in immunology 2019;10:2391
Frontiers in immunology 2019;10:2391
Immunosuppression by monocytic myeloid-derived suppressor cells in patients with pancreatic ductal carcinoma is orchestrated by STAT3.
Trovato R, Fiore A, Sartori S, Canè S, Giugno R, Cascione L, Paiella S, Salvia R, De Sanctis F, Poffe O, Anselmi C, Hofer F, Sartoris S, Piro G, Carbone C, Corbo V, Lawlor R, Solito S, Pinton L, Mandruzzato S, Bassi C, Scarpa A, Bronte V, Ugel S
Journal for immunotherapy of cancer 2019 Sep 18;7(1):255
Journal for immunotherapy of cancer 2019 Sep 18;7(1):255
Intrahepatic macrophage populations in the pathophysiology of primary sclerosing cholangitis.
Chen YY, Arndtz K, Webb G, Corrigan M, Akiror S, Liaskou E, Woodward P, Adams DH, Weston CJ, Hirschfield GM
JHEP reports : innovation in hepatology 2019 Nov;1(5):369-376
JHEP reports : innovation in hepatology 2019 Nov;1(5):369-376
Synthetic TRuC receptors engaging the complete T cell receptor for potent anti-tumor response.
Baeuerle PA, Ding J, Patel E, Thorausch N, Horton H, Gierut J, Scarfo I, Choudhary R, Kiner O, Krishnamurthy J, Le B, Morath A, Baldeviano GC, Quinn J, Tavares P, Wei Q, Weiler S, Maus MV, Getts D, Schamel WW, Hofmeister R
Nature communications 2019 May 7;10(1):2087
Nature communications 2019 May 7;10(1):2087
Suppression of R5-type of HIV-1 in CD4(+) NKT cells by Vδ1(+) T cells activated by flavonoid glycosides, hesperidin and linarin.
Yonekawa M, Shimizu M, Kaneko A, Matsumura J, Takahashi H
Scientific reports 2019 May 17;9(1):7506
Scientific reports 2019 May 17;9(1):7506
Antisense oligonucleotide targeting CD39 improves anti-tumor T cell immunity.
Kashyap AS, Thelemann T, Klar R, Kallert SM, Festag J, Buchi M, Hinterwimmer L, Schell M, Michel S, Jaschinski F, Zippelius A
Journal for immunotherapy of cancer 2019 Mar 12;7(1):67
Journal for immunotherapy of cancer 2019 Mar 12;7(1):67
Adaptive plasticity of IL-10(+) and IL-35(+) T(reg) cells cooperatively promotes tumor T cell exhaustion.
Sawant DV, Yano H, Chikina M, Zhang Q, Liao M, Liu C, Callahan DJ, Sun Z, Sun T, Tabib T, Pennathur A, Corry DB, Luketich JD, Lafyatis R, Chen W, Poholek AC, Bruno TC, Workman CJ, Vignali DAA
Nature immunology 2019 Jun;20(6):724-735
Nature immunology 2019 Jun;20(6):724-735
Efficient identification of neoantigen-specific T-cell responses in advanced human ovarian cancer.
Liu S, Matsuzaki J, Wei L, Tsuji T, Battaglia S, Hu Q, Cortes E, Wong L, Yan L, Long M, Miliotto A, Bateman NW, Lele SB, Chodon T, Koya RC, Yao S, Zhu Q, Conrads TP, Wang J, Maxwell GL, Lugade AA, Odunsi K
Journal for immunotherapy of cancer 2019 Jun 20;7(1):156
Journal for immunotherapy of cancer 2019 Jun 20;7(1):156
NK cells specifically TCR-dressed to kill cancer cells.
Mensali N, Dillard P, Hebeisen M, Lorenz S, Theodossiou T, Myhre MR, Fåne A, Gaudernack G, Kvalheim G, Myklebust JH, Inderberg EM, Wälchli S
EBioMedicine 2019 Feb;40:106-117
EBioMedicine 2019 Feb;40:106-117
Leptin induces TNFα-dependent inflammation in acquired generalized lipodystrophy and combined Crohn's disease.
Ziegler JF, Böttcher C, Letizia M, Yerinde C, Wu H, Freise I, Rodriguez-Sillke Y, Stoyanova AK, Kreis ME, Asbach P, Kunkel D, Priller J, Anagnostopoulos I, Kühl AA, Miehle K, Stumvoll M, Tran F, Fredrich B, Forster M, Franke A, Bojarski C, Glauben R, Löscher BS, Siegmund B, Weidinger C
Nature communications 2019 Dec 10;10(1):5629
Nature communications 2019 Dec 10;10(1):5629
Immunodeficiency and EBV-induced lymphoproliferation caused by 4-1BB deficiency.
Alosaimi MF, Hoenig M, Jaber F, Platt CD, Jones J, Wallace J, Debatin KM, Schulz A, Jacobsen E, Möller P, Shamseldin HE, Abdulwahab F, Ibrahim N, Alardati H, Almuhizi F, Abosoudah IF, Basha TA, Chou J, Alkuraya FS, Geha RS
The Journal of allergy and clinical immunology 2019 Aug;144(2):574-583.e5
The Journal of allergy and clinical immunology 2019 Aug;144(2):574-583.e5
Cutting Edge: IL-17B Uses IL-17RA and IL-17RB to Induce Type 2 Inflammation from Human Lymphocytes.
Ramirez-Carrozzi V, Ota N, Sambandam A, Wong K, Hackney J, Martinez-Martin N, Ouyang W, Pappu R
Journal of immunology (Baltimore, Md. : 1950) 2019 Apr 1;202(7):1935-1941
Journal of immunology (Baltimore, Md. : 1950) 2019 Apr 1;202(7):1935-1941
Filamin A Phosphorylation at Serine 2152 by the Serine/Threonine Kinase Ndr2 Controls TCR-Induced LFA-1 Activation in T Cells.
Waldt N, Seifert A, Demiray YE, Devroe E, Turk BE, Reichardt P, Mix C, Reinhold A, Freund C, Müller AJ, Schraven B, Stork O, Kliche S
Frontiers in immunology 2018;9:2852
Frontiers in immunology 2018;9:2852
A Stretch of Negatively Charged Amino Acids of Linker for Activation of T-Cell Adaptor Has a Dual Role in T-Cell Antigen Receptor Intracellular Signaling.
Arbulo-Echevarria MM, Narbona-Sánchez I, Fernandez-Ponce CM, Vico-Barranco I, Rueda-Ygueravide MD, Dustin ML, Miazek A, Duran-Ruiz MC, García-Cózar F, Aguado E
Frontiers in immunology 2018;9:115
Frontiers in immunology 2018;9:115
Combined Immunodeficiency in Patients With Trichohepatoenteric Syndrome.
Vély F, Barlogis V, Marinier E, Coste ME, Dubern B, Dugelay E, Lemale J, Martinez-Vinson C, Peretti N, Perry A, Bourgeois P, Badens C, Goulet O, Hugot JP, Farnarier C, Fabre A
Frontiers in immunology 2018;9:1036
Frontiers in immunology 2018;9:1036
Choice of costimulatory domains and of cytokines determines CAR T-cell activity in neuroblastoma.
Quintarelli C, Orlando D, Boffa I, Guercio M, Polito VA, Petretto A, Lavarello C, Sinibaldi M, Weber G, Del Bufalo F, Giorda E, Scarsella M, Petrini S, Pagliara D, Locatelli F, De Angelis B, Caruana I
Oncoimmunology 2018;7(6):e1433518
Oncoimmunology 2018;7(6):e1433518
Improved migration of tumor ascites lymphocytes to ovarian cancer microenvironment by CXCR2 transduction.
Idorn M, Olsen M, Halldórsdóttir HR, Skadborg SK, Pedersen M, Høgdall C, Høgdall E, Met Ö, Thor Straten P
Oncoimmunology 2018;7(4):e1412029
Oncoimmunology 2018;7(4):e1412029
The inhibitory checkpoint, PD-L2, is a target for effector T cells: Novel possibilities for immune therapy.
Ahmad SM, Martinenaite E, Holmström M, Jørgensen MA, Met Ö, Nastasi C, Klausen U, Donia M, Pedersen LM, Munksgaard L, Ødum N, Woetmann A, Svane IM, Andersen MH
Oncoimmunology 2018;7(2):e1390641
Oncoimmunology 2018;7(2):e1390641
Site-specific PEGylation of an anti-CEA/CD3 bispecific antibody improves its antitumor efficacy.
Pan H, Liu J, Deng W, Xing J, Li Q, Wang Z
International journal of nanomedicine 2018;13:3189-3201
International journal of nanomedicine 2018;13:3189-3201
A mutation in the progesterone receptor predisposes to HEV infection in HIV-positive patients.
Debes JD, Pas SD, Groothuismink ZMA, van der Ende ME, de Man RA, Boonstra A
Liver international : official journal of the International Association for the Study of the Liver 2018 May;38(5):792-796
Liver international : official journal of the International Association for the Study of the Liver 2018 May;38(5):792-796
Multiple Homozygous Variants in the STING-Encoding TMEM173 Gene in HIV Long-Term Nonprogressors.
Nissen SK, Pedersen JG, Helleberg M, Kjær K, Thavachelvam K, Obel N, Tolstrup M, Jakobsen MR, Mogensen TH
Journal of immunology (Baltimore, Md. : 1950) 2018 May 15;200(10):3372-3382
Journal of immunology (Baltimore, Md. : 1950) 2018 May 15;200(10):3372-3382
Functional and phenotypical analysis of IL-6-secreting CD4(+) T cells in human adipose tissue.
de Jong AJ, Pollastro S, Kwekkeboom JC, Andersen SN, Dorjée AL, Bakker AM, Alzaid F, Soprani A, Nelissen RGHH, Mullers JB, Venteclef N, de Vries N, Kloppenburg M, Toes REM, Ioan-Facsinay A
European journal of immunology 2018 Mar;48(3):471-481
European journal of immunology 2018 Mar;48(3):471-481
Targeting bladder cancer using activated T cells armed with bispecific antibodies.
Ma J, Ge J, Xue X, Xiu W, Ma P, Sun X, Zhang M
Oncology reports 2018 Mar;39(3):1245-1252
Oncology reports 2018 Mar;39(3):1245-1252
Adoptive Immunotherapy Using PRAME-Specific T Cells in Medulloblastoma.
Orlando D, Miele E, De Angelis B, Guercio M, Boffa I, Sinibaldi M, Po A, Caruana I, Abballe L, Carai A, Caruso S, Camera A, Moseley A, Hagedoorn RS, Heemskerk MHM, Giangaspero F, Mastronuzzi A, Ferretti E, Locatelli F, Quintarelli C
Cancer research 2018 Jun 15;78(12):3337-3349
Cancer research 2018 Jun 15;78(12):3337-3349
CD226 opposes TIGIT to disrupt Tregs in melanoma.
Fourcade J, Sun Z, Chauvin JM, Ka M, Davar D, Pagliano O, Wang H, Saada S, Menna C, Amin R, Sander C, Kirkwood JM, Korman AJ, Zarour HM
JCI insight 2018 Jul 26;3(14)
JCI insight 2018 Jul 26;3(14)
TCF1 expression marks self-renewing human CD8(+) T cells.
Kratchmarov R, Magun AM, Reiner SL
Blood advances 2018 Jul 24;2(14):1685-1690
Blood advances 2018 Jul 24;2(14):1685-1690
STAT5B: A Differential Regulator of the Life and Death of CD4(+) Effector Memory T Cells.
Majri SS, Fritz JM, Villarino AV, Zheng L, Kanellopoulou C, Chaigne-Delalande B, Grönholm J, Niemela JE, Afzali B, Biancalana M, Pittaluga S, Sun A, Cohen JL, Holland SM, O'Shea JJ, Uzel G, Lenardo MJ
Journal of immunology (Baltimore, Md. : 1950) 2018 Jan 1;200(1):110-118
Journal of immunology (Baltimore, Md. : 1950) 2018 Jan 1;200(1):110-118
Cytokine-induced alterations of BAMBI mediate the reciprocal regulation of human Th17/Treg cells in response to cigarette smoke extract.
Liu HJ, Chen G, Chen L, Zhou M, Xiong XZ, Meng ZJ, Sun SW, Tao XN
International journal of molecular medicine 2018 Dec;42(6):3404-3414
International journal of molecular medicine 2018 Dec;42(6):3404-3414
"Waltz" of Cell Membrane-Coated Nanoparticles on Lipid Bilayers: Tracking Single Particle Rotation in Ligand-Receptor Binding.
Yu Y, Gao Y, Yu Y
ACS nano 2018 Dec 26;12(12):11871-11880
ACS nano 2018 Dec 26;12(12):11871-11880
Discovery and preclinical characterization of the antagonist anti-PD-L1 monoclonal antibody LY3300054.
Li Y, Carpenito C, Wang G, Surguladze D, Forest A, Malabunga M, Murphy M, Zhang Y, Sonyi A, Chin D, Burtrum D, Inigo I, Pennello A, Shen L, Malherbe L, Chen X, Hall G, Haidar JN, Ludwig DL, Novosiadly RD, Kalos M
Journal for immunotherapy of cancer 2018 Apr 30;6(1):31
Journal for immunotherapy of cancer 2018 Apr 30;6(1):31
An Analysis of Trafficking Receptors Shows that CD44 and P-Selectin Glycoprotein Ligand-1 Collectively Control the Migration of Activated Human T-Cells.
Ali AJ, Abuelela AF, Merzaban JS
Frontiers in immunology 2017;8:492
Frontiers in immunology 2017;8:492
Dexamethasone and Monophosphoryl Lipid A Induce a Distinctive Profile on Monocyte-Derived Dendritic Cells through Transcriptional Modulation of Genes Associated With Essential Processes of the Immune Response.
García-González PA, Schinnerling K, Sepúlveda-Gutiérrez A, Maggi J, Mehdi AM, Nel HJ, Pesce B, Larrondo ML, Aravena O, Molina MC, Catalán D, Thomas R, Verdugo RA, Aguillón JC
Frontiers in immunology 2017;8:1350
Frontiers in immunology 2017;8:1350
Th2/1 Hybrid Cells Occurring in Murine and Human Strongyloidiasis Share Effector Functions of Th1 Cells.
Bock CN, Babu S, Breloer M, Rajamanickam A, Boothra Y, Brunn ML, Kühl AA, Merle R, Löhning M, Hartmann S, Rausch S
Frontiers in cellular and infection microbiology 2017;7:261
Frontiers in cellular and infection microbiology 2017;7:261
Expression and role of interleukin-9 in Vogt-Koyanagi-Harada disease.
Peng Z, Jiang S, Wu M, Zhou X, Wang Q
Molecular vision 2017;23:538-547
Molecular vision 2017;23:538-547
Functional characterization of T-cells from palatine tonsils in patients with chronic tonsillitis.
Geißler K, Markwart R, Requardt RP, Weigel C, Schubert K, Scherag A, Rubio I, Guntinas-Lichius O
PloS one 2017;12(9):e0183214
PloS one 2017;12(9):e0183214
Constitutive and activation-dependent phosphorylation of lymphocyte phosphatase-associated phosphoprotein (LPAP).
Kruglova NA, Meshkova TD, Kopylov AT, Mazurov DV, Filatov AV
PloS one 2017;12(8):e0182468
PloS one 2017;12(8):e0182468
A human tissue-based functional assay platform to evaluate the immune function impact of small molecule inhibitors that target the immune system.
St Pierre C, Guo J, Shin JD, Engstrom LW, Lee HH, Herbert A, Surdi L, Baker J, Salmon M, Shah S, Ellis JM, Houshyar H, Crackower MA, Kleinschek MA, Jones DC, Hicks A, Zaller DM, Alves SE, Ramadas RA
PloS one 2017;12(7):e0180870
PloS one 2017;12(7):e0180870
Differential immunomodulation in human monocytes versus macrophages by filarial cystatin.
Venugopal G, Mueller M, Hartmann S, Steinfelder S
PloS one 2017;12(11):e0188138
PloS one 2017;12(11):e0188138
Src-family kinases negatively regulate NFAT signaling in resting human T cells.
Baer A, Colon-Moran W, Xiang J, Stapleton JT, Bhattarai N
PloS one 2017;12(10):e0187123
PloS one 2017;12(10):e0187123
Restimulation-induced T-cell death through NTB-A/SAP signaling pathway is impaired in tuberculosis patients with depressed immune responses.
Hernández Del Pino RE, Pellegrini JM, Rovetta AI, Peña D, Álvarez GI, Rolandelli A, Musella RM, Palmero DJ, Malbran A, Pasquinelli V, García VE
Immunology and cell biology 2017 Sep;95(8):716-728
Immunology and cell biology 2017 Sep;95(8):716-728
Role of regulatory T cells in acute myeloid leukemia patients undergoing relapse-preventive immunotherapy.
Sander FE, Nilsson M, Rydström A, Aurelius J, Riise RE, Movitz C, Bernson E, Kiffin R, Ståhlberg A, Brune M, Foà R, Hellstrand K, Thorén FB, Martner A
Cancer immunology, immunotherapy : CII 2017 Nov;66(11):1473-1484
Cancer immunology, immunotherapy : CII 2017 Nov;66(11):1473-1484
Activity of lenalidomide in mantle cell lymphoma can be explained by NK cell-mediated cytotoxicity.
Hagner PR, Chiu H, Ortiz M, Apollonio B, Wang M, Couto S, Waldman MF, Flynt E, Ramsay AG, Trotter M, Gandhi AK, Chopra R, Thakurta A
British journal of haematology 2017 Nov;179(3):399-409
British journal of haematology 2017 Nov;179(3):399-409
HLA-B*14:02-Restricted Env-Specific CD8(+) T-Cell Activity Has Highly Potent Antiviral Efficacy Associated with Immune Control of HIV Infection.
Leitman EM, Willberg CB, Tsai MH, Chen H, Buus S, Chen F, Riddell L, Haas D, Fellay J, Goedert JJ, Piechocka-Trocha A, Walker BD, Martin J, Deeks S, Wolinsky SM, Martinson J, Martin M, Qi Y, Sáez-Cirión A, Yang OO, Matthews PC, Carrington M, Goulder PJR
Journal of virology 2017 Nov 15;91(22)
Journal of virology 2017 Nov 15;91(22)
Antigen presentation profiling reveals recognition of lymphoma immunoglobulin neoantigens.
Khodadoust MS, Olsson N, Wagar LE, Haabeth OA, Chen B, Swaminathan K, Rawson K, Liu CL, Steiner D, Lund P, Rao S, Zhang L, Marceau C, Stehr H, Newman AM, Czerwinski DK, Carlton VE, Moorhead M, Faham M, Kohrt HE, Carette J, Green MR, Davis MM, Levy R, Elias JE, Alizadeh AA
Nature 2017 Mar 30;543(7647):723-727
Nature 2017 Mar 30;543(7647):723-727
Clonal selection in the human Vδ1 T cell repertoire indicates γδ TCR-dependent adaptive immune surveillance.
Davey MS, Willcox CR, Joyce SP, Ladell K, Kasatskaya SA, McLaren JE, Hunter S, Salim M, Mohammed F, Price DA, Chudakov DM, Willcox BE
Nature communications 2017 Mar 1;8:14760
Nature communications 2017 Mar 1;8:14760
A 3D microfluidic model for preclinical evaluation of TCR-engineered T cells against solid tumors.
Pavesi A, Tan AT, Koh S, Chia A, Colombo M, Antonecchia E, Miccolis C, Ceccarello E, Adriani G, Raimondi MT, Kamm RD, Bertoletti A
JCI insight 2017 Jun 15;2(12)
JCI insight 2017 Jun 15;2(12)
FcγRIIIa Signaling Modulates Endosomal TLR Responses in Human CD4(+) T Cells.
Chauhan AK
Journal of immunology (Baltimore, Md. : 1950) 2017 Jun 15;198(12):4596-4606
Journal of immunology (Baltimore, Md. : 1950) 2017 Jun 15;198(12):4596-4606
Prolonged immunomodulation in inflammatory arthritis using the selective Kv1.3 channel blocker HsTX1[R14A] and its PEGylated analog.
Tanner MR, Tajhya RB, Huq R, Gehrmann EJ, Rodarte KE, Atik MA, Norton RS, Pennington MW, Beeton C
Clinical immunology (Orlando, Fla.) 2017 Jul;180:45-57
Clinical immunology (Orlando, Fla.) 2017 Jul;180:45-57
5T4-specific chimeric antigen receptor modification promotes the immune efficacy of cytokine-induced killer cells against nasopharyngeal carcinoma stem cell-like cells.
Guo X, Zheng H, Luo W, Zhang Q, Liu J, Yao K
Scientific reports 2017 Jul 7;7(1):4859
Scientific reports 2017 Jul 7;7(1):4859
CXCL4 Exposure Potentiates TLR-Driven Polarization of Human Monocyte-Derived Dendritic Cells and Increases Stimulation of T Cells.
Silva-Cardoso SC, Affandi AJ, Spel L, Cossu M, van Roon JAG, Boes M, Radstake TRDJ
Journal of immunology (Baltimore, Md. : 1950) 2017 Jul 1;199(1):253-262
Journal of immunology (Baltimore, Md. : 1950) 2017 Jul 1;199(1):253-262
A cycle of Zap70 kinase activation and release from the TCR amplifies and disperses antigenic stimuli.
Katz ZB, Novotná L, Blount A, Lillemeier BF
Nature immunology 2017 Jan;18(1):86-95
Nature immunology 2017 Jan;18(1):86-95
A Proteomic Survey Indicates Sortilin as a Secondary Substrate of the ER Translocation Inhibitor Cyclotriazadisulfonamide (CADA).
Van Puyenbroeck V, Claeys E, Schols D, Bell TW, Vermeire K
Molecular & cellular proteomics : MCP 2017 Feb;16(2):157-167
Molecular & cellular proteomics : MCP 2017 Feb;16(2):157-167
Hepatitis C virus infection inhibits a Src-kinase regulatory phosphatase and reduces T cell activation in vivo.
Bhattarai N, McLinden JH, Xiang J, Mathahs MM, Schmidt WN, Kaufman TM, Stapleton JT
PLoS pathogens 2017 Feb;13(2):e1006232
PLoS pathogens 2017 Feb;13(2):e1006232
Sorting nexin 27 interactome in T-lymphocytes identifies zona occludens-2 dynamic redistribution at the immune synapse.
Tello-Lafoz M, Martínez-Martínez G, Rodríguez-Rodríguez C, Albar JP, Huse M, Gharbi S, Merida I
Traffic (Copenhagen, Denmark) 2017 Aug;18(8):491-504
Traffic (Copenhagen, Denmark) 2017 Aug;18(8):491-504
Down-regulation of microRNA-451a facilitates the activation and proliferation of CD4(+) T cells by targeting Myc in patients with dilated cardiomyopathy.
Zeng Z, Wang K, Li Y, Xia N, Nie S, Lv B, Zhang M, Tu X, Li Q, Tang T, Cheng X
The Journal of biological chemistry 2017 Apr 7;292(14):6004-6013
The Journal of biological chemistry 2017 Apr 7;292(14):6004-6013
NOD1 modulates IL-10 signalling in human dendritic cells.
Neuper T, Ellwanger K, Schwarz H, Kufer TA, Duschl A, Horejs-Hoeck J
Scientific reports 2017 Apr 21;7(1):1005
Scientific reports 2017 Apr 21;7(1):1005
D120 and K152 within the PH Domain of T Cell Adapter SKAP55 Regulate Plasma Membrane Targeting of SKAP55 and LFA-1 Affinity Modulation in Human T Lymphocytes.
Witte A, Meineke B, Sticht J, Philipsen L, Kuropka B, Müller AJ, Freund C, Schraven B, Kliche S
Molecular and cellular biology 2017 Apr 1;37(7)
Molecular and cellular biology 2017 Apr 1;37(7)
Inhibiting Oxidative Phosphorylation In Vivo Restrains Th17 Effector Responses and Ameliorates Murine Colitis.
Franchi L, Monteleone I, Hao LY, Spahr MA, Zhao W, Liu X, Demock K, Kulkarni A, Lesch CA, Sanchez B, Carter L, Marafini I, Hu X, Mashadova O, Yuan M, Asara JM, Singh H, Lyssiotis CA, Monteleone G, Opipari AW, Glick GD
Journal of immunology (Baltimore, Md. : 1950) 2017 Apr 1;198(7):2735-2746
Journal of immunology (Baltimore, Md. : 1950) 2017 Apr 1;198(7):2735-2746
CD16(+) Monocyte Subset Was Enriched and Functionally Exacerbated in Driving T-Cell Activation and B-Cell Response in Systemic Lupus Erythematosus.
Zhu H, Hu F, Sun X, Zhang X, Zhu L, Liu X, Li X, Xu L, Shi L, Gan Y, Su Y
Frontiers in immunology 2016;7:512
Frontiers in immunology 2016;7:512
Umbilical Cord-Derived Mesenchymal Stem Cells Suppress Autophagy of T Cells in Patients with Systemic Lupus Erythematosus via Transfer of Mitochondria.
Chen J, Wang Q, Feng X, Zhang Z, Geng L, Xu T, Wang D, Sun L
Stem cells international 2016;2016:4062789
Stem cells international 2016;2016:4062789
Follicular Lymphoma Tregs Have a Distinct Transcription Profile Impacting Their Migration and Retention in the Malignant Lymph Node.
Nedelkovska H, Rosenberg AF, Hilchey SP, Hyrien O, Burack WR, Quataert SA, Baker CM, Azadniv M, Welle SL, Ansell SM, Kim M, Bernstein SH
PloS one 2016;11(5):e0155347
PloS one 2016;11(5):e0155347
Validation and Optimization of an Ex Vivo Assay of Intestinal Mucosal Biopsies in Crohn's Disease: Reflects Inflammation and Drug Effects.
Vadstrup K, Galsgaard ED, Gerwien J, Vester-Andersen MK, Pedersen JS, Rasmussen J, Neermark S, Kiszka-Kanowitz M, Jensen T, Bendtsen F
PloS one 2016;11(5):e0155335
PloS one 2016;11(5):e0155335
Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination.
Pageon SV, Tabarin T, Yamamoto Y, Ma Y, Nicovich PR, Bridgeman JS, Cohnen A, Benzing C, Gao Y, Crowther MD, Tungatt K, Dolton G, Sewell AK, Price DA, Acuto O, Parton RG, Gooding JJ, Rossy J, Rossjohn J, Gaus K
Proceedings of the National Academy of Sciences of the United States of America 2016 Sep 13;113(37):E5454-63
Proceedings of the National Academy of Sciences of the United States of America 2016 Sep 13;113(37):E5454-63
Differential effects of α4β7 and GPR15 on homing of effector and regulatory T cells from patients with UC to the inflamed gut in vivo.
Fischer A, Zundler S, Atreya R, Rath T, Voskens C, Hirschmann S, López-Posadas R, Watson A, Becker C, Schuler G, Neufert C, Atreya I, Neurath MF
Gut 2016 Oct;65(10):1642-64
Gut 2016 Oct;65(10):1642-64
A DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeleton.
Janssen E, Tohme M, Hedayat M, Leick M, Kumari S, Ramesh N, Massaad MJ, Ullas S, Azcutia V, Goodnow CC, Randall KL, Qiao Q, Wu H, Al-Herz W, Cox D, Hartwig J, Irvine DJ, Luscinskas FW, Geha RS
The Journal of clinical investigation 2016 Oct 3;126(10):3837-3851
The Journal of clinical investigation 2016 Oct 3;126(10):3837-3851
HCV core protein inhibits polarization and activity of both M1 and M2 macrophages through the TLR2 signaling pathway.
Zhang Q, Wang Y, Zhai N, Song H, Li H, Yang Y, Li T, Guo X, Chi B, Niu J, Crispe IN, Su L, Tu Z
Scientific reports 2016 Oct 27;6:36160
Scientific reports 2016 Oct 27;6:36160
Rational design of a Kv1.3 channel-blocking antibody as a selective immunosuppressant.
Wang RE, Wang Y, Zhang Y, Gabrelow C, Zhang Y, Chi V, Fu Q, Luo X, Wang D, Joseph S, Johnson K, Chatterjee AK, Wright TM, Nguyen-Tran VT, Teijaro J, Theofilopoulos AN, Schultz PG, Wang F
Proceedings of the National Academy of Sciences of the United States of America 2016 Oct 11;113(41):11501-11506
Proceedings of the National Academy of Sciences of the United States of America 2016 Oct 11;113(41):11501-11506
T-lymphocyte passive deformation is controlled by unfolding of membrane surface reservoirs.
Guillou L, Babataheri A, Saitakis M, Bohineust A, Dogniaux S, Hivroz C, Barakat AI, Husson J
Molecular biology of the cell 2016 Nov 7;27(22):3574-3582
Molecular biology of the cell 2016 Nov 7;27(22):3574-3582
Functional differences in hepatitis C virus nonstructural (NS) 3/4A- and 5A-specific T cell responses.
Holmström F, Chen M, Balasiddaiah A, Sällberg M, Ahlén G, Frelin L
Scientific reports 2016 May 4;6:24991
Scientific reports 2016 May 4;6:24991
Increased Th17 cells and IL-17A exist in patients with B cell acute lymphoblastic leukemia and promote proliferation and resistance to daunorubicin through activation of Akt signaling.
Bi L, Wu J, Ye A, Wu J, Yu K, Zhang S, Han Y
Journal of translational medicine 2016 May 12;14(1):132
Journal of translational medicine 2016 May 12;14(1):132
IL15 Agonists Overcome the Immunosuppressive Effects of MEK Inhibitors.
Allegrezza MJ, Rutkowski MR, Stephen TL, Svoronos N, Tesone AJ, Perales-Puchalt A, Nguyen JM, Sarmin F, Sheen MR, Jeng EK, Tchou J, Wong HC, Fiering SN, Conejo-Garcia JR
Cancer research 2016 May 1;76(9):2561-72
Cancer research 2016 May 1;76(9):2561-72
Obesity decreases B cell responses in young and elderly individuals.
Frasca D, Ferracci F, Diaz A, Romero M, Lechner S, Blomberg BB
Obesity (Silver Spring, Md.) 2016 Mar;24(3):615-25
Obesity (Silver Spring, Md.) 2016 Mar;24(3):615-25
Expression of the galectin-9-Tim-3 pathway in glioma tissues is associated with the clinical manifestations of glioma.
Liu Z, Han H, He X, Li S, Wu C, Yu C, Wang S
Oncology letters 2016 Mar;11(3):1829-1834
Oncology letters 2016 Mar;11(3):1829-1834
The adhesion molecule PECAM-1 enhances the TGF-β-mediated inhibition of T cell function.
Newman DK, Fu G, Adams T, Cui W, Arumugam V, Bluemn T, Riese MJ
Science signaling 2016 Mar 8;9(418):ra27
Science signaling 2016 Mar 8;9(418):ra27
IL-7 Induces SAMHD1 Phosphorylation in CD4+ T Lymphocytes, Improving Early Steps of HIV-1 Life Cycle.
Coiras M, Bermejo M, Descours B, Mateos E, García-Pérez J, López-Huertas MR, Lederman MM, Benkirane M, Alcamí J
Cell reports 2016 Mar 8;14(9):2100-2107
Cell reports 2016 Mar 8;14(9):2100-2107
Control of Foxp3 stability through modulation of TET activity.
Yue X, Trifari S, Äijö T, Tsagaratou A, Pastor WA, Zepeda-Martínez JA, Lio CW, Li X, Huang Y, Vijayanand P, Lähdesmäki H, Rao A
The Journal of experimental medicine 2016 Mar 7;213(3):377-97
The Journal of experimental medicine 2016 Mar 7;213(3):377-97
Combining FoxP3 and Helios with GARP/LAP markers can identify expanded Treg subsets in cancer patients.
Abd Al Samid M, Chaudhary B, Khaled YS, Ammori BJ, Elkord E
Oncotarget 2016 Mar 22;7(12):14083-94
Oncotarget 2016 Mar 22;7(12):14083-94
Human naïve regulatory T-cells feature high steady-state turnover and are maintained by IL-7.
Silva SL, Albuquerque AS, Serra-Caetano A, Foxall RB, Pires AR, Matoso P, Fernandes SM, Ferreira J, Cheynier R, Victorino RM, Caramalho I, Barata JT, Sousa AE
Oncotarget 2016 Mar 15;7(11):12163-75
Oncotarget 2016 Mar 15;7(11):12163-75
Implication of combined PD-L1/PD-1 blockade with cytokine-induced killer cells as a synergistic immunotherapy for gastrointestinal cancer.
Dai C, Lin F, Geng R, Ge X, Tang W, Chang J, Wu Z, Liu X, Lin Y, Zhang Z, Li J
Oncotarget 2016 Mar 1;7(9):10332-44
Oncotarget 2016 Mar 1;7(9):10332-44
A Small Molecule, Which Competes with MAdCAM-1, Activates Integrin α4β7 and Fails to Prevent Mucosal Transmission of SHIV-SF162P3.
Arrode-Brusés G, Goode D, Kleinbeck K, Wilk J, Frank I, Byrareddy S, Arthos J, Grasperge B, Blanchard J, Zydowsky T, Gettie A, Martinelli E
PLoS pathogens 2016 Jun;12(6):e1005720
PLoS pathogens 2016 Jun;12(6):e1005720
Human Galectin-9 Is a Potent Mediator of HIV Transcription and Reactivation.
Abdel-Mohsen M, Chavez L, Tandon R, Chew GM, Deng X, Danesh A, Keating S, Lanteri M, Samuels ML, Hoh R, Sacha JB, Norris PJ, Niki T, Shikuma CM, Hirashima M, Deeks SG, Ndhlovu LC, Pillai SK
PLoS pathogens 2016 Jun;12(6):e1005677
PLoS pathogens 2016 Jun;12(6):e1005677
Receptor-Targeted Nipah Virus Glycoproteins Improve Cell-Type Selective Gene Delivery and Reveal a Preference for Membrane-Proximal Cell Attachment.
Bender RR, Muth A, Schneider IC, Friedel T, Hartmann J, Plückthun A, Maisner A, Buchholz CJ
PLoS pathogens 2016 Jun;12(6):e1005641
PLoS pathogens 2016 Jun;12(6):e1005641
Golgi self-correction generates bioequivalent glycans to preserve cellular homeostasis.
Mkhikian H, Mortales CL, Zhou RW, Khachikyan K, Wu G, Haslam SM, Kavarian P, Dell A, Demetriou M
eLife 2016 Jun 8;5
eLife 2016 Jun 8;5
Granulocyte colony-stimulating factor impairs CD8(+) T cell functionality by interfering with central activation elements.
Bunse CE, Tischer S, Lahrberg J, Oelke M, Figueiredo C, Blasczyk R, Eiz-Vesper B
Clinical and experimental immunology 2016 Jul;185(1):107-18
Clinical and experimental immunology 2016 Jul;185(1):107-18
Calcium influx through CRAC channels controls actin organization and dynamics at the immune synapse.
Hartzell CA, Jankowska KI, Burkhardt JK, Lewis RS
eLife 2016 Jul 21;5
eLife 2016 Jul 21;5
Treg activation defect in type 1 diabetes: correction with TNFR2 agonism.
Okubo Y, Torrey H, Butterworth J, Zheng H, Faustman DL
Clinical & translational immunology 2016 Jan;5(1):e56
Clinical & translational immunology 2016 Jan;5(1):e56
Patients with MS under daclizumab therapy mount normal immune responses to influenza vaccination.
Lin YC, Winokur P, Blake A, Wu T, Manischewitz J, King LR, Romm E, Golding H, Bielekova B
Neurology(R) neuroimmunology & neuroinflammation 2016 Feb;3(1):e196
Neurology(R) neuroimmunology & neuroinflammation 2016 Feb;3(1):e196
Monocyte-derived inflammatory Langerhans cells and dermal dendritic cells mediate psoriasis-like inflammation.
Singh TP, Zhang HH, Borek I, Wolf P, Hedrick MN, Singh SP, Kelsall BL, Clausen BE, Farber JM
Nature communications 2016 Dec 16;7:13581
Nature communications 2016 Dec 16;7:13581
Genetically modified human CD4(+) T cells can be evaluated in vivo without lethal graft-versus-host disease.
Ali R, Babad J, Follenzi A, Gebe JA, Brehm MA, Nepom GT, Shultz LD, Greiner DL, DiLorenzo TP
Immunology 2016 Aug;148(4):339-51
Immunology 2016 Aug;148(4):339-51
MiRNA-22 inhibits oncogene galectin-1 in hepatocellular carcinoma.
You Y, Tan JX, Dai HS, Chen HW, Xu XJ, Yang AG, Zhang YJ, Bai LH, Bie P
Oncotarget 2016 Aug 30;7(35):57099-57116
Oncotarget 2016 Aug 30;7(35):57099-57116
Human TRAV1-2-negative MR1-restricted T cells detect S. pyogenes and alternatives to MAIT riboflavin-based antigens.
Meermeier EW, Laugel BF, Sewell AK, Corbett AJ, Rossjohn J, McCluskey J, Harriff MJ, Franks T, Gold MC, Lewinsohn DM
Nature communications 2016 Aug 16;7:12506
Nature communications 2016 Aug 16;7:12506
Synergistic COX2 Induction by IFNγ and TNFα Self-Limits Type-1 Immunity in the Human Tumor Microenvironment.
Wong JL, Obermajer N, Odunsi K, Edwards RP, Kalinski P
Cancer immunology research 2016 Apr;4(4):303-11
Cancer immunology research 2016 Apr;4(4):303-11
The Macrophage Galactose-Type C-Type Lectin (MGL) Modulates Regulatory T Cell Functions.
Zizzari IG, Martufi P, Battisti F, Rahimi H, Caponnetto S, Bellati F, Nuti M, Rughetti A, Napoletano C
PloS one 2015;10(7):e0132617
PloS one 2015;10(7):e0132617
Inflammatory IL-15 is required for optimal memory T cell responses.
Richer MJ, Pewe LL, Hancox LS, Hartwig SM, Varga SM, Harty JT
The Journal of clinical investigation 2015 Sep;125(9):3477-90
The Journal of clinical investigation 2015 Sep;125(9):3477-90
Conserved Motifs within Hepatitis C Virus Envelope (E2) RNA and Protein Independently Inhibit T Cell Activation.
Bhattarai N, McLinden JH, Xiang J, Kaufman TM, Stapleton JT
PLoS pathogens 2015 Sep;11(9):e1005183
PLoS pathogens 2015 Sep;11(9):e1005183
Direct tumor recognition by a human CD4(+) T-cell subset potently mediates tumor growth inhibition and orchestrates anti-tumor immune responses.
Matsuzaki J, Tsuji T, Luescher IF, Shiku H, Mineno J, Okamoto S, Old LJ, Shrikant P, Gnjatic S, Odunsi K
Scientific reports 2015 Oct 8;5:14896
Scientific reports 2015 Oct 8;5:14896
In-vitro Optimization of Nanoparticle-Cell Labeling Protocols for In-vivo Cell Tracking Applications.
Betzer O, Meir R, Dreifuss T, Shamalov K, Motiei M, Shwartz A, Baranes K, Cohen CJ, Shraga-Heled N, Ofir R, Yadid G, Popovtzer R
Scientific reports 2015 Oct 28;5:15400
Scientific reports 2015 Oct 28;5:15400
The human complement inhibitor Sushi Domain-Containing Protein 4 (SUSD4) expression in tumor cells and infiltrating T cells is associated with better prognosis of breast cancer patients.
Englund E, Reitsma B, King BC, Escudero-Esparza A, Owen S, Orimo A, Okroj M, Anagnostaki L, Jiang WG, Jirström K, Blom AM
BMC cancer 2015 Oct 19;15:737
BMC cancer 2015 Oct 19;15:737
Molecular difference between WASP and N-WASP critical for chemotaxis of T-cells towards SDF-1α.
Jain N, Thanabalu T
Scientific reports 2015 Oct 14;5:15031
Scientific reports 2015 Oct 14;5:15031
Dual-Affinity Re-Targeting proteins direct T cell-mediated cytolysis of latently HIV-infected cells.
Sung JA, Pickeral J, Liu L, Stanfield-Oakley SA, Lam CY, Garrido C, Pollara J, LaBranche C, Bonsignori M, Moody MA, Yang Y, Parks R, Archin N, Allard B, Kirchherr J, Kuruc JD, Gay CL, Cohen MS, Ochsenbauer C, Soderberg K, Liao HX, Montefiori D, Moore P, Johnson S, Koenig S, Haynes BF, Nordstrom JL, Margolis DM, Ferrari G
The Journal of clinical investigation 2015 Nov 2;125(11):4077-90
The Journal of clinical investigation 2015 Nov 2;125(11):4077-90
Increased Levels of Macrophage Inflammatory Proteins Result in Resistance to R5-Tropic HIV-1 in a Subset of Elite Controllers.
Walker WE, Kurscheid S, Joshi S, Lopez CA, Goh G, Choi M, Barakat L, Francis J, Fisher A, Kozal M, Zapata H, Shaw A, Lifton R, Sutton RE, Fikrig E
Journal of virology 2015 May;89(10):5502-14
Journal of virology 2015 May;89(10):5502-14
Broadening the repertoire of melanoma-associated T-cell epitopes.
Frøsig TM, Lyngaa R, Met Ö, Larsen SK, Donia M, Svane IM, Thor Straten P, Hadrup SR
Cancer immunology, immunotherapy : CII 2015 May;64(5):609-20
Cancer immunology, immunotherapy : CII 2015 May;64(5):609-20
Adenosine Receptor 2A Blockade Increases the Efficacy of Anti-PD-1 through Enhanced Antitumor T-cell Responses.
Beavis PA, Milenkovski N, Henderson MA, John LB, Allard B, Loi S, Kershaw MH, Stagg J, Darcy PK
Cancer immunology research 2015 May;3(5):506-17
Cancer immunology research 2015 May;3(5):506-17
TIGIT and PD-1 impair tumor antigen-specific CD8⁺ T cells in melanoma patients.
Chauvin JM, Pagliano O, Fourcade J, Sun Z, Wang H, Sander C, Kirkwood JM, Chen TH, Maurer M, Korman AJ, Zarour HM
The Journal of clinical investigation 2015 May;125(5):2046-58
The Journal of clinical investigation 2015 May;125(5):2046-58
A novel antibody-drug conjugate targeting SAIL for the treatment of hematologic malignancies.
Kim SY, Theunissen JW, Balibalos J, Liao-Chan S, Babcock MC, Wong T, Cairns B, Gonzalez D, van der Horst EH, Perez M, Levashova Z, Chinn L, D'Alessio JA, Flory M, Bermudez A, Jackson DY, Ha E, Monteon J, Bruhns MF, Chen G, Migone TS
Blood cancer journal 2015 May 29;5(5):e316
Blood cancer journal 2015 May 29;5(5):e316
The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway.
Goodfellow HS, Frushicheva MP, Ji Q, Cheng DA, Kadlecek TA, Cantor AJ, Kuriyan J, Chakraborty AK, Salomon A, Weiss A
Science signaling 2015 May 19;8(377):ra49
Science signaling 2015 May 19;8(377):ra49
TLR5 Ligand-Secreting T Cells Reshape the Tumor Microenvironment and Enhance Antitumor Activity.
Geng D, Kaczanowska S, Tsai A, Younger K, Ochoa A, Rapoport AP, Ostrand-Rosenberg S, Davila E
Cancer research 2015 May 15;75(10):1959-1971
Cancer research 2015 May 15;75(10):1959-1971
IL-12 secreting tumor-targeted chimeric antigen receptor T cells eradicate ovarian tumors in vivo.
Koneru M, Purdon TJ, Spriggs D, Koneru S, Brentjens RJ
Oncoimmunology 2015 Mar;4(3):e994446
Oncoimmunology 2015 Mar;4(3):e994446
c-CBL E3 ubiquitin ligase is overexpressed in cutaneous T-cell lymphoma: its inhibition promotes activation-induced cell death.
Wu J, Salva KA, Wood GS
The Journal of investigative dermatology 2015 Mar;135(3):861-868
The Journal of investigative dermatology 2015 Mar;135(3):861-868
Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathway.
Kumari S, Depoil D, Martinelli R, Judokusumo E, Carmona G, Gertler FB, Kam LC, Carman CV, Burkhardt JK, Irvine DJ, Dustin ML
eLife 2015 Mar 11;4
eLife 2015 Mar 11;4
Mutations in early follicular lymphoma progenitors are associated with suppressed antigen presentation.
Green MR, Kihira S, Liu CL, Nair RV, Salari R, Gentles AJ, Irish J, Stehr H, Vicente-Dueñas C, Romero-Camarero I, Sanchez-Garcia I, Plevritis SK, Arber DA, Batzoglou S, Levy R, Alizadeh AA
Proceedings of the National Academy of Sciences of the United States of America 2015 Mar 10;112(10):E1116-25
Proceedings of the National Academy of Sciences of the United States of America 2015 Mar 10;112(10):E1116-25
Activated human valvular interstitial cells sustain interleukin-17 production to recruit neutrophils in infective endocarditis.
Yeh CY, Shun CT, Kuo YM, Jung CJ, Hsieh SC, Chiu YL, Chen JW, Hsu RB, Yang CJ, Chia JS
Infection and immunity 2015 Jun;83(6):2202-12
Infection and immunity 2015 Jun;83(6):2202-12
PD-1+Tim-3+ CD8+ T Lymphocytes Display Varied Degrees of Functional Exhaustion in Patients with Regionally Metastatic Differentiated Thyroid Cancer.
Severson JJ, Serracino HS, Mateescu V, Raeburn CD, McIntyre RC Jr, Sams SB, Haugen BR, French JD
Cancer immunology research 2015 Jun;3(6):620-30
Cancer immunology research 2015 Jun;3(6):620-30
South African HIV-1 subtype C transmitted variants with a specific V2 motif show higher dependence on α4β7 for replication.
Richardson SI, Gray ES, Mkhize NN, Sheward DJ, Lambson BE, Wibmer CK, Masson L, Werner L, Garrett N, Passmore JA, Karim QA, Karim SS, Williamson C, Moore PL, Morris L
Retrovirology 2015 Jun 24;12:54
Retrovirology 2015 Jun 24;12:54
Fatal autoimmunity in mice reconstituted with human hematopoietic stem cells encoding defective FOXP3.
Goettel JA, Biswas S, Lexmond WS, Yeste A, Passerini L, Patel B, Yang S, Sun J, Ouahed J, Shouval DS, McCann KJ, Horwitz BH, Mathis D, Milford EL, Notarangelo LD, Roncarolo MG, Fiebiger E, Marasco WA, Bacchetta R, Quintana FJ, Pai SY, Klein C, Muise AM, Snapper SB
Blood 2015 Jun 18;125(25):3886-95
Blood 2015 Jun 18;125(25):3886-95
Mature cystic fibrosis airway neutrophils suppress T cell function: evidence for a role of arginase 1 but not programmed death-ligand 1.
Ingersoll SA, Laval J, Forrest OA, Preininger M, Brown MR, Arafat D, Gibson G, Tangpricha V, Tirouvanziam R
Journal of immunology (Baltimore, Md. : 1950) 2015 Jun 1;194(11):5520-8
Journal of immunology (Baltimore, Md. : 1950) 2015 Jun 1;194(11):5520-8
Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53.
Yoon KW, Byun S, Kwon E, Hwang SY, Chu K, Hiraki M, Jo SH, Weins A, Hakroush S, Cebulla A, Sykes DB, Greka A, Mundel P, Fisher DE, Mandinova A, Lee SW
Science (New York, N.Y.) 2015 Jul 31;349(6247):1261669
Science (New York, N.Y.) 2015 Jul 31;349(6247):1261669
Autoregulatory function of interleukin-10-producing pre-naïve B cells is defective in systemic lupus erythematosus.
Sim JH, Kim HR, Chang SH, Kim IJ, Lipsky PE, Lee J
Arthritis research & therapy 2015 Jul 25;17(1):190
Arthritis research & therapy 2015 Jul 25;17(1):190
Human NK cell repertoire diversity reflects immune experience and correlates with viral susceptibility.
Strauss-Albee DM, Fukuyama J, Liang EC, Yao Y, Jarrell JA, Drake AL, Kinuthia J, Montgomery RR, John-Stewart G, Holmes S, Blish CA
Science translational medicine 2015 Jul 22;7(297):297ra115
Science translational medicine 2015 Jul 22;7(297):297ra115
Chemotherapy-Derived Inflammatory Responses Accelerate the Formation of Immunosuppressive Myeloid Cells in the Tissue Microenvironment of Human Pancreatic Cancer.
Takeuchi S, Baghdadi M, Tsuchikawa T, Wada H, Nakamura T, Abe H, Nakanishi S, Usui Y, Higuchi K, Takahashi M, Inoko K, Sato S, Takano H, Shichinohe T, Seino K, Hirano S
Cancer research 2015 Jul 1;75(13):2629-40
Cancer research 2015 Jul 1;75(13):2629-40
Integrative analysis of T cell motility from multi-channel microscopy data using TIAM.
Mayya V, Neiswanger W, Medina R, Wiggins CH, Dustin ML
Journal of immunological methods 2015 Jan;416:84-93
Journal of immunological methods 2015 Jan;416:84-93
Tryptophan 2,3-dioxygenase (TDO)-reactive T cells differ in their functional characteristics in health and cancer.
Hjortsø MD, Larsen SK, Kongsted P, Met Ö, Frøsig TM, Andersen GH, Ahmad SM, Svane IM, Becker JC, Straten PT, Andersen MH
Oncoimmunology 2015 Jan;4(1):e968480
Oncoimmunology 2015 Jan;4(1):e968480
Ex vivo expansion of human T cells for adoptive immunotherapy using the novel Xeno-free CTS Immune Cell Serum Replacement.
Smith C, Økern G, Rehan S, Beagley L, Lee SK, Aarvak T, Schjetne KW, Khanna R
Clinical & translational immunology 2015 Jan;4(1):e31
Clinical & translational immunology 2015 Jan;4(1):e31
Towards programming immune tolerance through geometric manipulation of phosphatidylserine.
Roberts RA, Eitas TK, Byrne JD, Johnson BM, Short PJ, McKinnon KP, Reisdorf S, Luft JC, DeSimone JM, Ting JP
Biomaterials 2015 Dec;72:1-10
Biomaterials 2015 Dec;72:1-10
Bone marrow-derived mesenchymal stromal cells harness purinergenic signaling to tolerize human Th1 cells in vivo.
Amarnath S, Foley JE, Farthing DE, Gress RE, Laurence A, Eckhaus MA, Métais JY, Rose JJ, Hakim FT, Felizardo TC, Cheng AV, Robey PG, Stroncek DE, Sabatino M, Battiwalla M, Ito S, Fowler DH, Barrett AJ
Stem cells (Dayton, Ohio) 2015 Apr;33(4):1200-12
Stem cells (Dayton, Ohio) 2015 Apr;33(4):1200-12
Blocking GluR2-GAPDH ameliorates experimental autoimmune encephalomyelitis.
Zhai D, Lee FH, D'Souza C, Su P, Zhang S, Jia Z, Zhang L, Wong AH, Liu F
Annals of clinical and translational neurology 2015 Apr;2(4):388-400
Annals of clinical and translational neurology 2015 Apr;2(4):388-400
Increased presence of FOXP3+ regulatory T cells in inflamed muscle of patients with active juvenile dermatomyositis compared to peripheral blood.
Vercoulen Y, Bellutti Enders F, Meerding J, Plantinga M, Elst EF, Varsani H, van Schieveen C, Bakker MH, Klein M, Scholman RC, Spliet W, Ricotti V, Koenen HJ, de Weger RA, Wedderburn LR, van Royen-Kerkhof A, Prakken BJ
PloS one 2014;9(8):e105353
PloS one 2014;9(8):e105353
Dendritic cells loaded with pancreatic Cancer Stem Cells (CSCs) lysates induce antitumor immune killing effect in vitro.
Yin T, Shi P, Gou S, Shen Q, Wang C
PloS one 2014;9(12):e114581
PloS one 2014;9(12):e114581
TL1A induces TCR independent IL-6 and TNF-α production and growth of PLZF⁺ leukocytes.
Reichwald K, Jørgensen TZ, Tougaard P, Skov S
PloS one 2014;9(1):e85793
PloS one 2014;9(1):e85793
The generation of induced pluripotent stem cells for macular degeneration as a drug screening platform: identification of curcumin as a protective agent for retinal pigment epithelial cells against oxidative stress.
Chang YC, Chang WC, Hung KH, Yang DM, Cheng YH, Liao YW, Woung LC, Tsai CY, Hsu CC, Lin TC, Liu JH, Chiou SH, Peng CH, Chen SJ
Frontiers in aging neuroscience 2014;6:191
Frontiers in aging neuroscience 2014;6:191
Spontaneous presence of FOXO3-specific T cells in cancer patients.
Larsen SK, Ahmad SM, Idorn M, Met Ö, Martinenaite E, Svane IM, Straten PT, Andersen MH
Oncoimmunology 2014;3(8):e953411
Oncoimmunology 2014;3(8):e953411
Exploring T cell reactivity to gliadin in young children with newly diagnosed celiac disease.
Liu E, McDaniel K, Case S, Yu L, Gerhartz B, Ostermann N, Fankhauser G, Hungerford V, Zou C, Luyten M, Seidl KJ, Michels AW
Autoimmune diseases 2014;2014:927190
Autoimmune diseases 2014;2014:927190
A truncated human NKG2D splice isoform negatively regulates NKG2D-mediated function.
Karimi MA, Aguilar O, Zou B, Bachmann MH, Carlyle JR, Baldwin CL, Kambayashi T
Journal of immunology (Baltimore, Md. : 1950) 2014 Sep 15;193(6):2764-2771
Journal of immunology (Baltimore, Md. : 1950) 2014 Sep 15;193(6):2764-2771
Activation and propagation of tumor-infiltrating lymphocytes on clinical-grade designer artificial antigen-presenting cells for adoptive immunotherapy of melanoma.
Forget MA, Malu S, Liu H, Toth C, Maiti S, Kale C, Haymaker C, Bernatchez C, Huls H, Wang E, Marincola FM, Hwu P, Cooper LJ, Radvanyi LG
Journal of immunotherapy (Hagerstown, Md. : 1997) 2014 Nov-Dec;37(9):448-60
Journal of immunotherapy (Hagerstown, Md. : 1997) 2014 Nov-Dec;37(9):448-60
An NCR1-based chimeric receptor endows T-cells with multiple anti-tumor specificities.
Tal Y, Yaakobi S, Horovitz-Fried M, Safyon E, Rosental B, Porgador A, Cohen CJ
Oncotarget 2014 Nov 15;5(21):10949-58
Oncotarget 2014 Nov 15;5(21):10949-58
Akt-dependent enhanced migratory capacity of Th17 cells from children with lupus nephritis.
Kshirsagar S, Riedl M, Billing H, Tönshoff B, Thangavadivel S, Steuber C, Staude H, Wechselberger G, Edelbauer M
Journal of immunology (Baltimore, Md. : 1950) 2014 Nov 15;193(10):4895-903
Journal of immunology (Baltimore, Md. : 1950) 2014 Nov 15;193(10):4895-903
Exposure to a histone deacetylase inhibitor has detrimental effects on human lymphocyte viability and function.
Wong DJ, Rao A, Avramis E, Matsunaga DR, Komatsubara KM, Atefi MS, Escuin-Ordinas H, Chodon T, Koya RC, Ribas A, Comin-Anduix B
Cancer immunology research 2014 May;2(5):459-68
Cancer immunology research 2014 May;2(5):459-68
NKG2D- and CD28-mediated costimulation regulate CD8+ T cell chemotaxis through different mechanisms: the role of Cdc42/N-WASp.
Serrano-Pertierra E, Cernuda-Morollón E, López-Larrea C
Journal of leukocyte biology 2014 Mar;95(3):487-95
Journal of leukocyte biology 2014 Mar;95(3):487-95
Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4(CRBN.).
Gandhi AK, Kang J, Havens CG, Conklin T, Ning Y, Wu L, Ito T, Ando H, Waldman MF, Thakurta A, Klippel A, Handa H, Daniel TO, Schafer PH, Chopra R
British journal of haematology 2014 Mar;164(6):811-21
British journal of haematology 2014 Mar;164(6):811-21
High CTLA-4 expression on Th17 cells results in increased sensitivity to CTLA-4 coinhibition and resistance to belatacept.
Krummey SM, Cheeseman JA, Conger JA, Jang PS, Mehta AK, Kirk AD, Larsen CP, Ford ML
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2014 Mar;14(3):607-14
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2014 Mar;14(3):607-14
Non-overlapping functions of Nck1 and Nck2 adaptor proteins in T cell activation.
Ngoenkam J, Paensuwan P, Preechanukul K, Khamsri B, Yiemwattana I, Beck-García E, Minguet S, Schamel WW, Pongcharoen S
Cell communication and signaling : CCS 2014 Mar 26;12:21
Cell communication and signaling : CCS 2014 Mar 26;12:21
Genuine Immunomodulation With dSLIM.
Kapp K, Kleuss C, Schroff M, Wittig B
Molecular therapy. Nucleic acids 2014 Jun 24;3(6):e170
Molecular therapy. Nucleic acids 2014 Jun 24;3(6):e170
Adenosine triphosphate acts as a paracrine signaling molecule to reduce the motility of T cells.
Wang CM, Ploia C, Anselmi F, Sarukhan A, Viola A
The EMBO journal 2014 Jun 17;33(12):1354-64
The EMBO journal 2014 Jun 17;33(12):1354-64
Bioengineering T cells to target carbohydrate to treat opportunistic fungal infection.
Kumaresan PR, Manuri PR, Albert ND, Maiti S, Singh H, Mi T, Roszik J, Rabinovich B, Olivares S, Krishnamurthy J, Zhang L, Najjar AM, Huls MH, Lee DA, Champlin RE, Kontoyiannis DP, Cooper LJ
Proceedings of the National Academy of Sciences of the United States of America 2014 Jul 22;111(29):10660-5
Proceedings of the National Academy of Sciences of the United States of America 2014 Jul 22;111(29):10660-5
N-glycosylation of asparagine 8 regulates surface expression of major histocompatibility complex class I chain-related protein A (MICA) alleles dependent on threonine 24.
Mellergaard M, Skovbakke SL, Schneider CL, Lauridsen F, Andresen L, Jensen H, Skov S
The Journal of biological chemistry 2014 Jul 18;289(29):20078-91
The Journal of biological chemistry 2014 Jul 18;289(29):20078-91
Human Th2 but not Th9 cells release IL-31 in a STAT6/NF-κB-dependent way.
Maier E, Werner D, Duschl A, Bohle B, Horejs-Hoeck J
Journal of immunology (Baltimore, Md. : 1950) 2014 Jul 15;193(2):645-54
Journal of immunology (Baltimore, Md. : 1950) 2014 Jul 15;193(2):645-54
Prevailing role of contact guidance in intrastromal T-cell trapping in human pancreatic cancer.
Hartmann N, Giese NA, Giese T, Poschke I, Offringa R, Werner J, Ryschich E
Clinical cancer research : an official journal of the American Association for Cancer Research 2014 Jul 1;20(13):3422-33
Clinical cancer research : an official journal of the American Association for Cancer Research 2014 Jul 1;20(13):3422-33
Development of virus-specific CD4+ and CD8+ regulatory T cells induced by human herpesvirus 6 infection.
Wang F, Chi J, Peng G, Zhou F, Wang J, Li L, Feng D, Xie F, Gu B, Qin J, Chen Y, Yao K
Journal of virology 2014 Jan;88(2):1011-24
Journal of virology 2014 Jan;88(2):1011-24
Comparative transcriptional and functional profiling defines conserved programs of intestinal DC differentiation in humans and mice.
Watchmaker PB, Lahl K, Lee M, Baumjohann D, Morton J, Kim SJ, Zeng R, Dent A, Ansel KM, Diamond B, Hadeiba H, Butcher EC
Nature immunology 2014 Jan;15(1):98-108
Nature immunology 2014 Jan;15(1):98-108
A dual-targeting triplebody mediates preferential redirected lysis of antigen double-positive over single-positive leukemic cells.
Schubert I, Saul D, Nowecki S, Mackensen A, Fey GH, Oduncu FS
mAbs 2014 Jan-Feb;6(1):286-96
mAbs 2014 Jan-Feb;6(1):286-96
Long-lasting disease stabilization in the absence of toxicity in metastatic lung cancer patients vaccinated with an epitope derived from indoleamine 2,3 dioxygenase.
Iversen TZ, Engell-Noerregaard L, Ellebaek E, Andersen R, Larsen SK, Bjoern J, Zeyher C, Gouttefangeas C, Thomsen BM, Holm B, Thor Straten P, Mellemgaard A, Andersen MH, Svane IM
Clinical cancer research : an official journal of the American Association for Cancer Research 2014 Jan 1;20(1):221-32
Clinical cancer research : an official journal of the American Association for Cancer Research 2014 Jan 1;20(1):221-32
Inhibition of the immunoproteasome ameliorates experimental autoimmune encephalomyelitis.
Basler M, Mundt S, Muchamuel T, Moll C, Jiang J, Groettrup M, Kirk CJ
EMBO molecular medicine 2014 Feb;6(2):226-38
EMBO molecular medicine 2014 Feb;6(2):226-38
Building and optimizing a virus-specific T cell receptor library for targeted immunotherapy in viral infections.
Banu N, Chia A, Ho ZZ, Garcia AT, Paravasivam K, Grotenbreg GM, Bertoletti A, Gehring AJ
Scientific reports 2014 Feb 25;4:4166
Scientific reports 2014 Feb 25;4:4166
Dual-specificity phosphatase 14 (DUSP14/MKP6) negatively regulates TCR signaling by inhibiting TAB1 activation.
Yang CY, Li JP, Chiu LL, Lan JL, Chen DY, Chuang HC, Huang CY, Tan TH
Journal of immunology (Baltimore, Md. : 1950) 2014 Feb 15;192(4):1547-57
Journal of immunology (Baltimore, Md. : 1950) 2014 Feb 15;192(4):1547-57
High IP-10 levels decrease T cell function in HIV-1-infected individuals on ART.
Ramirez LA, Arango TA, Thompson E, Naji M, Tebas P, Boyer JD
Journal of leukocyte biology 2014 Dec;96(6):1055-63
Journal of leukocyte biology 2014 Dec;96(6):1055-63
Bispecific anti-CD3 x anti-HER2 antibody mediates T cell cytolytic activity to HER2-positive colorectal cancer in vitro and in vivo.
Han H, Ma J, Zhang K, Li W, Liu C, Zhang Y, Zhang G, Ma P, Wang L, Zhang G, Tao H, Gao B
International journal of oncology 2014 Dec;45(6):2446-54
International journal of oncology 2014 Dec;45(6):2446-54
HIF-1α- and hypoxia-dependent immune responses in human CD4+CD25high T cells and T helper 17 cells.
Bollinger T, Gies S, Naujoks J, Feldhoff L, Bollinger A, Solbach W, Rupp J
Journal of leukocyte biology 2014 Aug;96(2):305-12
Journal of leukocyte biology 2014 Aug;96(2):305-12
Recombinant IgG2a Fc (M045) multimers effectively suppress experimental autoimmune myasthenia gravis.
Thiruppathi M, Sheng JR, Li L, Prabhakar BS, Meriggioli MN
Journal of autoimmunity 2014 Aug;52:64-73
Journal of autoimmunity 2014 Aug;52:64-73
Histone deacetylase inhibitors impair the elimination of HIV-infected cells by cytotoxic T-lymphocytes.
Jones RB, O'Connor R, Mueller S, Foley M, Szeto GL, Karel D, Lichterfeld M, Kovacs C, Ostrowski MA, Trocha A, Irvine DJ, Walker BD
PLoS pathogens 2014 Aug;10(8):e1004287
PLoS pathogens 2014 Aug;10(8):e1004287
Calmodulin and PI(3,4,5)P₃ cooperatively bind to the Itk pleckstrin homology domain to promote efficient calcium signaling and IL-17A production.
Wang X, Boyken SE, Hu J, Xu X, Rimer RP, Shea MA, Shaw AS, Andreotti AH, Huang YH
Science signaling 2014 Aug 5;7(337):ra74
Science signaling 2014 Aug 5;7(337):ra74
Wiskott-Aldrich Syndrome causing mutation, Pro373Ser restricts conformational changes essential for WASP activity in T-cells.
Jain N, George B, Thanabalu T
Biochimica et biophysica acta 2014 Apr;1842(4):623-34
Biochimica et biophysica acta 2014 Apr;1842(4):623-34
CD4CD8αα lymphocytes, a novel human regulatory T cell subset induced by colonic bacteria and deficient in patients with inflammatory bowel disease.
Sarrabayrouse G, Bossard C, Chauvin JM, Jarry A, Meurette G, Quévrain E, Bridonneau C, Preisser L, Asehnoune K, Labarrière N, Altare F, Sokol H, Jotereau F
PLoS biology 2014 Apr;12(4):e1001833
PLoS biology 2014 Apr;12(4):e1001833
Alternative capture of noncoding RNAs or protein-coding genes by herpesviruses to alter host T cell function.
Guo YE, Riley KJ, Iwasaki A, Steitz JA
Molecular cell 2014 Apr 10;54(1):67-79
Molecular cell 2014 Apr 10;54(1):67-79
T-cell responses to oncogenic merkel cell polyomavirus proteins distinguish patients with merkel cell carcinoma from healthy donors.
Lyngaa R, Pedersen NW, Schrama D, Thrue CA, Ibrani D, Met O, Thor Straten P, Nghiem P, Becker JC, Hadrup SR
Clinical cancer research : an official journal of the American Association for Cancer Research 2014 Apr 1;20(7):1768-78
Clinical cancer research : an official journal of the American Association for Cancer Research 2014 Apr 1;20(7):1768-78
Novel CD47: SIRPα dependent mechanism for the activation of STAT3 in antigen-presenting cell.
Toledano N, Gur-Wahnon D, Ben-Yehuda A, Rachmilewitz J
PloS one 2013;8(9):e75595
PloS one 2013;8(9):e75595
HER2 as a promising target for cytotoxicity T cells in human melanoma therapy.
Ma J, Han H, Liu D, Li W, Feng H, Xue X, Wu X, Niu G, Zhang G, Zhao Y, Liu C, Tao H, Gao B
PloS one 2013;8(8):e73261
PloS one 2013;8(8):e73261
Cyclotides Suppress Human T-Lymphocyte Proliferation by an Interleukin 2-Dependent Mechanism.
Gründemann C, Thell K, Lengen K, Garcia-Käufer M, Huang YH, Huber R, Craik DJ, Schabbauer G, Gruber CW
PloS one 2013;8(6):e68016
PloS one 2013;8(6):e68016
Activated human nasal epithelial cells modulate specific antibody response against bacterial or viral antigens.
Yeh CY, Yeh TH, Jung CJ, Chen PL, Lien HT, Chia JS
PloS one 2013;8(2):e55472
PloS one 2013;8(2):e55472
Impaired functionality of antiviral T cells in G-CSF mobilized stem cell donors: implications for the selection of CTL donor.
Bunse CE, Borchers S, Varanasi PR, Tischer S, Figueiredo C, Immenschuh S, Kalinke U, Köhl U, Goudeva L, Maecker-Kolhoff B, Ganser A, Blasczyk R, Weissinger EM, Eiz-Vesper B
PloS one 2013;8(12):e77925
PloS one 2013;8(12):e77925
IL-4 confers resistance to IL-27-mediated suppression on CD4+ T cells by impairing signal transducer and activator of transcription 1 signaling.
Chen Z, Wang S, Erekosima N, Li Y, Hong J, Qi X, Merkel P, Nagabhushanam V, Choo E, Katial R, Alam R, Trikha A, Chu HW, Zhuang Y, Jin M, Bai C, Huang H
The Journal of allergy and clinical immunology 2013 Oct;132(4):912-21.e1-5
The Journal of allergy and clinical immunology 2013 Oct;132(4):912-21.e1-5
IL-2-inducible T-cell kinase modulates TH2-mediated allergic airway inflammation by suppressing IFN-γ in naive CD4+ T cells.
Kannan AK, Sahu N, Mohanan S, Mohinta S, August A
The Journal of allergy and clinical immunology 2013 Oct;132(4):811-20.e1-5
The Journal of allergy and clinical immunology 2013 Oct;132(4):811-20.e1-5
Intercellular adhesion molecule 1 mediates migration of Th1 and Th17 cells across human retinal vascular endothelium.
Bharadwaj AS, Schewitz-Bowers LP, Wei L, Lee RW, Smith JR
Investigative ophthalmology & visual science 2013 Oct 23;54(10):6917-25
Investigative ophthalmology & visual science 2013 Oct 23;54(10):6917-25
Human T cells engineered to express a programmed death 1/28 costimulatory retargeting molecule display enhanced antitumor activity.
Ankri C, Shamalov K, Horovitz-Fried M, Mauer S, Cohen CJ
Journal of immunology (Baltimore, Md. : 1950) 2013 Oct 15;191(8):4121-9
Journal of immunology (Baltimore, Md. : 1950) 2013 Oct 15;191(8):4121-9
LAT1 is a critical transporter of essential amino acids for immune reactions in activated human T cells.
Hayashi K, Jutabha P, Endou H, Sagara H, Anzai N
Journal of immunology (Baltimore, Md. : 1950) 2013 Oct 15;191(8):4080-5
Journal of immunology (Baltimore, Md. : 1950) 2013 Oct 15;191(8):4080-5
Effects of conventional therapeutic interventions on the number and function of regulatory T cells.
Roselli M, Cereda V, di Bari MG, Formica V, Spila A, Jochems C, Farsaci B, Donahue R, Gulley JL, Schlom J, Guadagni F
Oncoimmunology 2013 Oct 1;2(10):e27025
Oncoimmunology 2013 Oct 1;2(10):e27025
CD137L-stimulated dendritic cells are more potent than conventional dendritic cells at eliciting cytotoxic T-cell responses.
Harfuddin Z, Kwajah S, Chong Nyi Sim A, Macary PA, Schwarz H
Oncoimmunology 2013 Nov 1;2(11):e26859
Oncoimmunology 2013 Nov 1;2(11):e26859
CD70-CD27 ligation between neural stem cells and CD4+ T cells induces Fas-FasL-mediated T-cell death.
Lee EM, Hurh S, Cho B, Oh KH, Kim SU, Surh CD, Sprent J, Yang J, Kim JY, Ahn C
Stem cell research & therapy 2013 May 21;4(3):56
Stem cell research & therapy 2013 May 21;4(3):56
Fine-tuning of regulatory T cell function: the role of calcium signals and naive regulatory T cells for regulatory T cell deficiency in multiple sclerosis.
Schwarz A, Schumacher M, Pfaff D, Schumacher K, Jarius S, Balint B, Wiendl H, Haas J, Wildemann B
Journal of immunology (Baltimore, Md. : 1950) 2013 May 15;190(10):4965-70
Journal of immunology (Baltimore, Md. : 1950) 2013 May 15;190(10):4965-70
Peptide library-based evaluation of T-cell receptor breadth detects defects in global and regulatory activation in human immunologic diseases.
Barber JS, Yokomizo LK, Sheikh V, Freeman AF, Garabedian E, van Dijk E, Sokolic R, Candotti F, Weng NP, Sereti I, Milner JD
Proceedings of the National Academy of Sciences of the United States of America 2013 May 14;110(20):8164-9
Proceedings of the National Academy of Sciences of the United States of America 2013 May 14;110(20):8164-9
Human neonatal naive CD4+ T cells have enhanced activation-dependent signaling regulated by the microRNA miR-181a.
Palin AC, Ramachandran V, Acharya S, Lewis DB
Journal of immunology (Baltimore, Md. : 1950) 2013 Mar 15;190(6):2682-91
Journal of immunology (Baltimore, Md. : 1950) 2013 Mar 15;190(6):2682-91
The zinc-binding region of IL-2 inducible T cell kinase (Itk) is required for interaction with Gα13 and activation of serum response factor.
Huang W, Morales JL, Gazivoda VP, Lai J, Qi Q, August A
The international journal of biochemistry & cell biology 2013 Jun;45(6):1074-82
The international journal of biochemistry & cell biology 2013 Jun;45(6):1074-82
Adipocyte-derived lipids modulate CD4+ T-cell function.
Ioan-Facsinay A, Kwekkeboom JC, Westhoff S, Giera M, Rombouts Y, van Harmelen V, Huizinga TW, Deelder A, Kloppenburg M, Toes RE
European journal of immunology 2013 Jun;43(6):1578-87
European journal of immunology 2013 Jun;43(6):1578-87
Methylation of FOXP3 in regulatory T cells is related to the severity of coronary artery disease.
Jia L, Zhu L, Wang JZ, Wang XJ, Chen JZ, Song L, Wu YJ, Sun K, Yuan ZY, Hui R
Atherosclerosis 2013 Jun;228(2):346-52
Atherosclerosis 2013 Jun;228(2):346-52
GB virus C particles inhibit T cell activation via envelope E2 protein-mediated inhibition of TCR signaling.
Bhattarai N, McLinden JH, Xiang J, Landay AL, Chivero ET, Stapleton JT
Journal of immunology (Baltimore, Md. : 1950) 2013 Jun 15;190(12):6351-9
Journal of immunology (Baltimore, Md. : 1950) 2013 Jun 15;190(12):6351-9
HHLA2 is a member of the B7 family and inhibits human CD4 and CD8 T-cell function.
Zhao R, Chinai JM, Buhl S, Scandiuzzi L, Ray A, Jeon H, Ohaegbulam KC, Ghosh K, Zhao A, Scharff MD, Zang X
Proceedings of the National Academy of Sciences of the United States of America 2013 Jun 11;110(24):9879-84
Proceedings of the National Academy of Sciences of the United States of America 2013 Jun 11;110(24):9879-84
Mesenchymal stem cells from periapical lesions modulate differentiation and functional properties of monocyte-derived dendritic cells.
Dokić J, Tomić S, Marković M, Milosavljević P, Colić M
European journal of immunology 2013 Jul;43(7):1862-72
European journal of immunology 2013 Jul;43(7):1862-72
Up-regulation of proliferative and migratory genes in regulatory T cells from patients with metastatic castration-resistant prostate cancer.
Huen NY, Pang AL, Tucker JA, Lee TL, Vergati M, Jochems C, Intrivici C, Cereda V, Chan WY, Rennert OM, Madan RA, Gulley JL, Schlom J, Tsang KY
International journal of cancer 2013 Jul 15;133(2):373-82
International journal of cancer 2013 Jul 15;133(2):373-82
Phase I trial of a multi-epitope-pulsed dendritic cell vaccine for patients with newly diagnosed glioblastoma.
Phuphanich S, Wheeler CJ, Rudnick JD, Mazer M, Wang H, Nuño MA, Richardson JE, Fan X, Ji J, Chu RM, Bender JG, Hawkins ES, Patil CG, Black KL, Yu JS
Cancer immunology, immunotherapy : CII 2013 Jan;62(1):125-35
Cancer immunology, immunotherapy : CII 2013 Jan;62(1):125-35
Enhanced function of redirected human T cells expressing linker for activation of T cells that is resistant to ubiquitylation.
Kunii N, Zhao Y, Jiang S, Liu X, Scholler J, Balagopalan L, Samelson LE, Milone MC, June CH
Human gene therapy 2013 Jan;24(1):27-37
Human gene therapy 2013 Jan;24(1):27-37
Nuclear translocation of MEK1 triggers a complex T cell response through the corepressor silencing mediator of retinoid and thyroid hormone receptor.
Guo L, Chen C, Liang Q, Karim MZ, Gorska MM, Alam R
Journal of immunology (Baltimore, Md. : 1950) 2013 Jan 1;190(1):159-67
Journal of immunology (Baltimore, Md. : 1950) 2013 Jan 1;190(1):159-67
Anti-KIT designer T cells for the treatment of gastrointestinal stromal tumor.
Katz SC, Burga RA, Naheed S, Licata LA, Thorn M, Osgood D, Nguyen CT, Espat NJ, Fletcher JA, Junghans RP
Journal of translational medicine 2013 Feb 21;11:46
Journal of translational medicine 2013 Feb 21;11:46
Beta-lactam antibiotics modulate T-cell functions and gene expression via covalent binding to cellular albumin.
Mor F, Cohen IR
Proceedings of the National Academy of Sciences of the United States of America 2013 Feb 19;110(8):2981-6
Proceedings of the National Academy of Sciences of the United States of America 2013 Feb 19;110(8):2981-6
LINE-1 retrotransposable element DNA accumulates in HIV-1-infected cells.
Jones RB, Song H, Xu Y, Garrison KE, Buzdin AA, Anwar N, Hunter DV, Mujib S, Mihajlovic V, Martin E, Lee E, Kuciak M, Raposo RA, Bozorgzad A, Meiklejohn DA, Ndhlovu LC, Nixon DF, Ostrowski MA
Journal of virology 2013 Dec;87(24):13307-20
Journal of virology 2013 Dec;87(24):13307-20
Anti-tumor necrosis factor α targets protein kinase B/c-Akt-induced resistance of effector cells to suppression in juvenile idiopathic arthritis.
Wehrens EJ, Vastert SJ, Mijnheer G, Meerding J, Klein M, Wulffraat NM, Prakken BJ, van Wijk F
Arthritis and rheumatism 2013 Dec;65(12):3279-84
Arthritis and rheumatism 2013 Dec;65(12):3279-84
B7-H4Ig inhibits mouse and human T-cell function and treats EAE via IL-10/Treg-dependent mechanisms.
Podojil JR, Liu LN, Marshall SA, Chiang MY, Goings GE, Chen L, Langermann S, Miller SD
Journal of autoimmunity 2013 Aug;44:71-81
Journal of autoimmunity 2013 Aug;44:71-81
Activation of the transcriptional function of the NF-κB protein c-Rel by O-GlcNAc glycosylation.
Ramakrishnan P, Clark PM, Mason DE, Peters EC, Hsieh-Wilson LC, Baltimore D
Science signaling 2013 Aug 27;6(290):ra75
Science signaling 2013 Aug 27;6(290):ra75
Toward eliminating HLA class I expression to generate universal cells from allogeneic donors.
Torikai H, Reik A, Soldner F, Warren EH, Yuen C, Zhou Y, Crossland DL, Huls H, Littman N, Zhang Z, Tykodi SS, Kebriaei P, Lee DA, Miller JC, Rebar EJ, Holmes MC, Jaenisch R, Champlin RE, Gregory PD, Cooper LJ
Blood 2013 Aug 22;122(8):1341-9
Blood 2013 Aug 22;122(8):1341-9
Soluble GARP has potent antiinflammatory and immunomodulatory impact on human CD4⁺ T cells.
Hahn SA, Stahl HF, Becker C, Correll A, Schneider FJ, Tuettenberg A, Jonuleit H
Blood 2013 Aug 15;122(7):1182-91
Blood 2013 Aug 15;122(7):1182-91
A practical approach to immunotherapy of hepatocellular carcinoma using T cells redirected against hepatitis B virus.
Koh S, Shimasaki N, Suwanarusk R, Ho ZZ, Chia A, Banu N, Howland SW, Ong AS, Gehring AJ, Stauss H, Renia L, Sällberg M, Campana D, Bertoletti A
Molecular therapy. Nucleic acids 2013 Aug 13;2(8):e114
Molecular therapy. Nucleic acids 2013 Aug 13;2(8):e114
Hypomorphic Janus kinase 3 mutations result in a spectrum of immune defects, including partial maternal T-cell engraftment.
Cattaneo F, Recher M, Masneri S, Baxi SN, Fiorini C, Antonelli F, Wysocki CA, Calderon JG, Eibel H, Smith AR, Bonilla FA, Tsitsikov E, Giliani S, Notarangelo LD, Pai SY
The Journal of allergy and clinical immunology 2013 Apr;131(4):1136-45
The Journal of allergy and clinical immunology 2013 Apr;131(4):1136-45
Low-dose interleukin-2 therapy restores regulatory T cell homeostasis in patients with chronic graft-versus-host disease.
Matsuoka K, Koreth J, Kim HT, Bascug G, McDonough S, Kawano Y, Murase K, Cutler C, Ho VT, Alyea EP, Armand P, Blazar BR, Antin JH, Soiffer RJ, Ritz J
Science translational medicine 2013 Apr 3;5(179):179ra43
Science translational medicine 2013 Apr 3;5(179):179ra43
Transmitted/founder and chronic subtype C HIV-1 use CD4 and CCR5 receptors with equal efficiency and are not inhibited by blocking the integrin α4β7.
Parrish NF, Wilen CB, Banks LB, Iyer SS, Pfaff JM, Salazar-Gonzalez JF, Salazar MG, Decker JM, Parrish EH, Berg A, Hopper J, Hora B, Kumar A, Mahlokozera T, Yuan S, Coleman C, Vermeulen M, Ding H, Ochsenbauer C, Tilton JC, Permar SR, Kappes JC, Betts MR, Busch MP, Gao F, Montefiori D, Haynes BF, Shaw GM, Hahn BH, Doms RW
PLoS pathogens 2012;8(5):e1002686
PLoS pathogens 2012;8(5):e1002686
Biochemical and functional studies of lymphoid-specific tyrosine phosphatase (Lyp) variants S201F and R266W.
Liu J, Chen M, Li R, Yang F, Shi X, Zhu L, Wang HM, Yao W, Liu Q, Meng FG, Sun JP, Pang Q, Yu X
PloS one 2012;7(8):e43631
PloS one 2012;7(8):e43631
Global activation of CD8+ cytotoxic T lymphocytes correlates with an impairment in regulatory T cells in patients with generalized vitiligo.
Lili Y, Yi W, Ji Y, Yue S, Weimin S, Ming L
PloS one 2012;7(5):e37513
PloS one 2012;7(5):e37513
Cannabinoid receptor 2-mediated attenuation of CXCR4-tropic HIV infection in primary CD4+ T cells.
Costantino CM, Gupta A, Yewdall AW, Dale BM, Devi LA, Chen BK
PloS one 2012;7(3):e33961
PloS one 2012;7(3):e33961
Apoptotic effects of antilymphocyte globulins on human pro-inflammatory CD4+CD28- T-cells.
Duftner C, Dejaco C, Hengster P, Bijuklic K, Joannidis M, Margreiter R, Schirmer M
PloS one 2012;7(3):e33939
PloS one 2012;7(3):e33939
HSP70 enhances immunosuppressive function of CD4(+)CD25(+)FoxP3(+) T regulatory cells and cytotoxicity in CD4(+)CD25(-) T cells.
Wachstein J, Tischer S, Figueiredo C, Limbourg A, Falk C, Immenschuh S, Blasczyk R, Eiz-Vesper B
PloS one 2012;7(12):e51747
PloS one 2012;7(12):e51747
A cancer vaccine induces expansion of NY-ESO-1-specific regulatory T cells in patients with advanced melanoma.
Ebert LM, MacRaild SE, Zanker D, Davis ID, Cebon J, Chen W
PloS one 2012;7(10):e48424
PloS one 2012;7(10):e48424
Fermented mistletoe extract as a multimodal antitumoral agent in gliomas.
Podlech O, Harter PN, Mittelbronn M, Pöschel S, Naumann U
Evidence-based complementary and alternative medicine : eCAM 2012;2012:501796
Evidence-based complementary and alternative medicine : eCAM 2012;2012:501796
Inhibition of activation induced CD154 on CD4+ CD25- cells: a valid surrogate for human Treg suppressor function.
Hill D, Eastaff-Leung N, Bresatz-Atkins S, Warner N, Ruitenberg J, Krumbiegel D, Pederson S, McInnes N, Brown CY, Sadlon T, Barry SC
Immunology and cell biology 2012 Sep;90(8):812-21
Immunology and cell biology 2012 Sep;90(8):812-21
Engagement of T-cell antigen receptor and CD4/CD8 co-receptors induces prolonged STAT activation through autocrine/paracrine stimulation in human primary T cells.
Chueh FY, Yu CL
Biochemical and biophysical research communications 2012 Sep 21;426(2):242-6
Biochemical and biophysical research communications 2012 Sep 21;426(2):242-6
Lymphocyte-polarized dendritic cells are highly effective in inducing tumor-specific CTLs.
Berk E, Muthuswamy R, Kalinski P
Vaccine 2012 Sep 21;30(43):6216-24
Vaccine 2012 Sep 21;30(43):6216-24
Novel humanized and highly efficient bispecific antibodies mediate killing of prostate stem cell antigen-expressing tumor cells by CD8+ and CD4+ T cells.
Feldmann A, Arndt C, Töpfer K, Stamova S, Krone F, Cartellieri M, Koristka S, Michalk I, Lindemann D, Schmitz M, Temme A, Bornhäuser M, Ehninger G, Bachmann M
Journal of immunology (Baltimore, Md. : 1950) 2012 Sep 15;189(6):3249-59
Journal of immunology (Baltimore, Md. : 1950) 2012 Sep 15;189(6):3249-59
GB virus C envelope protein E2 inhibits TCR-induced IL-2 production and alters IL-2-signaling pathways.
Bhattarai N, McLinden JH, Xiang J, Kaufman TM, Stapleton JT
Journal of immunology (Baltimore, Md. : 1950) 2012 Sep 1;189(5):2211-6
Journal of immunology (Baltimore, Md. : 1950) 2012 Sep 1;189(5):2211-6
Cytokine secretion by CD4+ T cells at the immunological synapse requires Cdc42-dependent local actin remodeling but not microtubule organizing center polarity.
Chemin K, Bohineust A, Dogniaux S, Tourret M, Guégan S, Miro F, Hivroz C
Journal of immunology (Baltimore, Md. : 1950) 2012 Sep 1;189(5):2159-68
Journal of immunology (Baltimore, Md. : 1950) 2012 Sep 1;189(5):2159-68
Expression and isotopic labelling of the potassium channel blocker ShK toxin as a thioredoxin fusion protein in bacteria.
Chang SC, Galea CA, Leung EW, Tajhya RB, Beeton C, Pennington MW, Norton RS
Toxicon : official journal of the International Society on Toxinology 2012 Oct;60(5):840-50
Toxicon : official journal of the International Society on Toxinology 2012 Oct;60(5):840-50
Polycomb antagonizes p300/CREB-binding protein-associated factor to silence FOXP3 in a Kruppel-like factor-dependent manner.
Xiong Y, Khanna S, Grzenda AL, Sarmento OF, Svingen PA, Lomberk GA, Urrutia RA, Faubion WA Jr
The Journal of biological chemistry 2012 Oct 5;287(41):34372-85
The Journal of biological chemistry 2012 Oct 5;287(41):34372-85
TCR-redirected human T cells inhibit hepatitis C virus replication: hepatotoxic potential is linked to antigen specificity and functional avidity.
Pasetto A, Frelin L, Aleman S, Holmström F, Brass A, Ahlén G, Brenndörfer ED, Lohmann V, Bartenschlager R, Sällberg M, Bertoletti A, Chen M
Journal of immunology (Baltimore, Md. : 1950) 2012 Nov 1;189(9):4510-9
Journal of immunology (Baltimore, Md. : 1950) 2012 Nov 1;189(9):4510-9
K12/SECTM1, an interferon-γ regulated molecule, synergizes with CD28 to costimulate human T cell proliferation.
Wang T, Huang C, Lopez-Coral A, Slentz-Kesler KA, Xiao M, Wherry EJ, Kaufman RE
Journal of leukocyte biology 2012 Mar;91(3):449-59
Journal of leukocyte biology 2012 Mar;91(3):449-59
Emergence of peripheral CD3+CD56+ cytokine-induced killer cell in HIV-1-infected Chinese children.
Fu GF, Chen X, Hu HY, Yang HT, Xu XQ, Qiu T, Li L, Xu JS, Huan XP, Hou YY
International immunology 2012 Mar;24(3):197-206
International immunology 2012 Mar;24(3):197-206
DNGR-1 is a specific and universal marker of mouse and human Batf3-dependent dendritic cells in lymphoid and nonlymphoid tissues.
Poulin LF, Reyal Y, Uronen-Hansson H, Schraml BU, Sancho D, Murphy KM, Håkansson UK, Moita LF, Agace WW, Bonnet D, Reis e Sousa C
Blood 2012 Jun 21;119(25):6052-62
Blood 2012 Jun 21;119(25):6052-62
A foundation for universal T-cell based immunotherapy: T cells engineered to express a CD19-specific chimeric-antigen-receptor and eliminate expression of endogenous TCR.
Torikai H, Reik A, Liu PQ, Zhou Y, Zhang L, Maiti S, Huls H, Miller JC, Kebriaei P, Rabinovich B, Lee DA, Champlin RE, Bonini C, Naldini L, Rebar EJ, Gregory PD, Holmes MC, Cooper LJ
Blood 2012 Jun 14;119(24):5697-705
Blood 2012 Jun 14;119(24):5697-705
A predictive biomimetic model of cytokine release induced by TGN1412 and other therapeutic monoclonal antibodies.
Dhir V, Fort M, Mahmood A, Higbee R, Warren W, Narayanan P, Wittman V
Journal of immunotoxicology 2012 Jan-Mar;9(1):34-42
Journal of immunotoxicology 2012 Jan-Mar;9(1):34-42
Loss of the signaling adaptor TRAF1 causes CD8+ T cell dysregulation during human and murine chronic infection.
Wang C, McPherson AJ, Jones RB, Kawamura KS, Lin GH, Lang PA, Ambagala T, Pellegrini M, Calzascia T, Aidarus N, Elford AR, Yue FY, Kremmer E, Kovacs CM, Benko E, Tremblay C, Routy JP, Bernard NF, Ostrowski MA, Ohashi PS, Watts TH
The Journal of experimental medicine 2012 Jan 16;209(1):77-91
The Journal of experimental medicine 2012 Jan 16;209(1):77-91
Trogocytosis is a gateway to characterize functional diversity in melanoma-specific CD8+ T cell clones.
Uzana R, Eisenberg G, Sagi Y, Frankenburg S, Merims S, Amariglio N, Yefenof E, Peretz T, Machlenkin A, Lotem M
Journal of immunology (Baltimore, Md. : 1950) 2012 Jan 15;188(2):632-40
Journal of immunology (Baltimore, Md. : 1950) 2012 Jan 15;188(2):632-40
Phenotypic complexity of T regulatory subsets in patients with B-chronic lymphocytic leukemia.
Biancotto A, Dagur PK, Fuchs JC, Wiestner A, Bagwell CB, McCoy JP Jr
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2012 Feb;25(2):246-59
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2012 Feb;25(2):246-59
Differential mTOR and ERK pathway utilization by effector CD4 T cells suggests combinatorial drug therapy of arthritis.
Lin JT, Stein EA, Wong MT, Kalpathy KJ, Su LL, Utz PJ, Robinson WH, Fathman CG
Clinical immunology (Orlando, Fla.) 2012 Feb;142(2):127-38
Clinical immunology (Orlando, Fla.) 2012 Feb;142(2):127-38
A mutation in the human Uncoordinated 119 gene impairs TCR signaling and is associated with CD4 lymphopenia.
Gorska MM, Alam R
Blood 2012 Feb 9;119(6):1399-406
Blood 2012 Feb 9;119(6):1399-406
Do plant cyclotides have potential as immunosuppressant peptides?
Gründemann C, Koehbach J, Huber R, Gruber CW
Journal of natural products 2012 Feb 24;75(2):167-74
Journal of natural products 2012 Feb 24;75(2):167-74
Production of TNF-α in macrophages activated by T cells, compared with lipopolysaccharide, uses distinct IL-10-dependent regulatory mechanism.
Agbanoma G, Li C, Ennis D, Palfreeman AC, Williams LM, Brennan FM
Journal of immunology (Baltimore, Md. : 1950) 2012 Feb 1;188(3):1307-17
Journal of immunology (Baltimore, Md. : 1950) 2012 Feb 1;188(3):1307-17
Blood-derived human iPS cells generate optic vesicle-like structures with the capacity to form retinal laminae and develop synapses.
Phillips MJ, Wallace KA, Dickerson SJ, Miller MJ, Verhoeven AD, Martin JM, Wright LS, Shen W, Capowski EE, Percin EF, Perez ET, Zhong X, Canto-Soler MV, Gamm DM
Investigative ophthalmology & visual science 2012 Apr 18;53(4):2007-19
Investigative ophthalmology & visual science 2012 Apr 18;53(4):2007-19
Licensing virus-specific T cells to secrete the neutrophil attracting chemokine CXCL-8 during hepatitis B virus infection.
Gehring AJ, Koh S, Chia A, Paramasivam K, Chew VS, Ho ZZ, Lee KH, Maini MK, Madhavan K, Lim SG, Bertoletti A
PloS one 2011;6(8):e23330
PloS one 2011;6(8):e23330
Follicular lymphoma tumor-infiltrating T-helper (T(H)) cells have the same polyfunctional potential as normal nodal T(H) cells despite skewed differentiation.
Hilchey SP, Rosenberg AF, Hyrien O, Secor-Socha S, Cochran MR, Brady MT, Wang JC, Sanz I, Burack WR, Quataert SA, Bernstein SH
Blood 2011 Sep 29;118(13):3591-602
Blood 2011 Sep 29;118(13):3591-602
Functional human regulatory T cells fail to control autoimmune inflammation due to PKB/c-akt hyperactivation in effector cells.
Wehrens EJ, Mijnheer G, Duurland CL, Klein M, Meerding J, van Loosdregt J, de Jager W, Sawitzki B, Coffer PJ, Vastert B, Prakken BJ, van Wijk F
Blood 2011 Sep 29;118(13):3538-48
Blood 2011 Sep 29;118(13):3538-48
Functional gap junctions accumulate at the immunological synapse and contribute to T cell activation.
Mendoza-Naranjo A, Bouma G, Pereda C, Ramírez M, Webb KF, Tittarelli A, López MN, Kalergis AM, Thrasher AJ, Becker DL, Salazar-Onfray F
Journal of immunology (Baltimore, Md. : 1950) 2011 Sep 15;187(6):3121-32
Journal of immunology (Baltimore, Md. : 1950) 2011 Sep 15;187(6):3121-32
Enhanced phosphoinositide 3-kinase δ activity is a frequent event in systemic lupus erythematosus that confers resistance to activation-induced T cell death.
Suárez-Fueyo A, Barber DF, Martínez-Ara J, Zea-Mendoza AC, Carrera AC
Journal of immunology (Baltimore, Md. : 1950) 2011 Sep 1;187(5):2376-85
Journal of immunology (Baltimore, Md. : 1950) 2011 Sep 1;187(5):2376-85
Engineering T cells specific for a dominant severe acute respiratory syndrome coronavirus CD8 T cell epitope.
Oh HL, Chia A, Chang CX, Leong HN, Ling KL, Grotenbreg GM, Gehring AJ, Tan YJ, Bertoletti A
Journal of virology 2011 Oct;85(20):10464-71
Journal of virology 2011 Oct;85(20):10464-71
Increased frequency of regulatory T cells accompanies increased immune activation in rectal mucosae of HIV-positive noncontrollers.
Shaw JM, Hunt PW, Critchfield JW, McConnell DH, Garcia JC, Pollard RB, Somsouk M, Deeks SG, Shacklett BL
Journal of virology 2011 Nov;85(21):11422-34
Journal of virology 2011 Nov;85(21):11422-34
Low telomerase activity in CD4+ regulatory T cells in patients with severe chronic GVHD after hematopoietic stem cell transplantation.
Kawano Y, Kim HT, Matsuoka K, Bascug G, McDonough S, Ho VT, Cutler C, Koreth J, Alyea EP, Antin JH, Soiffer RJ, Ritz J
Blood 2011 Nov 3;118(18):5021-30
Blood 2011 Nov 3;118(18):5021-30
A critical role for STAT3 transcription factor signaling in the development and maintenance of human T cell memory.
Siegel AM, Heimall J, Freeman AF, Hsu AP, Brittain E, Brenchley JM, Douek DC, Fahle GH, Cohen JI, Holland SM, Milner JD
Immunity 2011 Nov 23;35(5):806-18
Immunity 2011 Nov 23;35(5):806-18
Atorvastatin upregulates regulatory T cells and reduces clinical disease activity in patients with rheumatoid arthritis.
Tang TT, Song Y, Ding YJ, Liao YH, Yu X, Du R, Xiao H, Yuan J, Zhou ZH, Liao MY, Yao R, Jevallee H, Shi GP, Cheng X
Journal of lipid research 2011 May;52(5):1023-32
Journal of lipid research 2011 May;52(5):1023-32
The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells.
Motomura Y, Kitamura H, Hijikata A, Matsunaga Y, Matsumoto K, Inoue H, Atarashi K, Hori S, Watarai H, Zhu J, Taniguchi M, Kubo M
Nature immunology 2011 May;12(5):450-9
Nature immunology 2011 May;12(5):450-9
In vitro and in vivo model of a novel immunotherapy approach for chronic lymphocytic leukemia by anti-CD23 chimeric antigen receptor.
Giordano Attianese GM, Marin V, Hoyos V, Savoldo B, Pizzitola I, Tettamanti S, Agostoni V, Parma M, Ponzoni M, Bertilaccio MT, Ghia P, Biondi A, Dotti G, Biagi E
Blood 2011 May 5;117(18):4736-45
Blood 2011 May 5;117(18):4736-45
Predicting cytotoxic T-cell age from multivariate analysis of static and dynamic biomarkers.
Rivet CA, Hill AS, Lu H, Kemp ML
Molecular & cellular proteomics : MCP 2011 Mar;10(3):M110.003921
Molecular & cellular proteomics : MCP 2011 Mar;10(3):M110.003921
NKG2D receptor regulates human effector T-cell cytokine production.
Barber A, Sentman CL
Blood 2011 Jun 16;117(24):6571-81
Blood 2011 Jun 16;117(24):6571-81
An HIV-1 gp120 envelope human monoclonal antibody that recognizes a C1 conformational epitope mediates potent antibody-dependent cellular cytotoxicity (ADCC) activity and defines a common ADCC epitope in human HIV-1 serum.
Ferrari G, Pollara J, Kozink D, Harms T, Drinker M, Freel S, Moody MA, Alam SM, Tomaras GD, Ochsenbauer C, Kappes JC, Shaw GM, Hoxie JA, Robinson JE, Haynes BF
Journal of virology 2011 Jul;85(14):7029-36
Journal of virology 2011 Jul;85(14):7029-36
Maturation of human dendritic cells with Saccharomyces cerevisiae (yeast) reduces the number and function of regulatory T cells and enhances the ratio of antigen-specific effectors to regulatory T cells.
Cereda V, Vergati M, Huen NY, di Bari MG, Jochems C, Intrivici C, Gulley JL, Apelian D, Schlom J, Tsang KY
Vaccine 2011 Jul 12;29(31):4992-9
Vaccine 2011 Jul 12;29(31):4992-9
Serine residues in the LAT adaptor are essential for TCR-dependent signal transduction.
Martínez-Florensa M, García-Blesa A, Yélamos J, Muñoz-Suano A, Domínguez-Villar M, Valdor R, Alonso A, García-Cózar F, Aparicio P, Malissen B, Aguado E
Journal of leukocyte biology 2011 Jan;89(1):63-73
Journal of leukocyte biology 2011 Jan;89(1):63-73
SHP2 is a target of the immunosuppressant tautomycetin.
Liu S, Yu Z, Yu X, Huang SX, Luo Y, Wu L, Shen W, Yang Z, Wang L, Gunawan AM, Chan RJ, Shen B, Zhang ZY
Chemistry & biology 2011 Jan 28;18(1):101-10
Chemistry & biology 2011 Jan 28;18(1):101-10
Heat shock protein 27 differentiates tolerogenic macrophages that may support human breast cancer progression.
Banerjee S, Lin CF, Skinner KA, Schiffhauer LM, Peacock J, Hicks DG, Redmond EM, Morrow D, Huston A, Shayne M, Langstein HN, Miller-Graziano CL, Strickland J, O'Donoghue L, De AK
Cancer research 2011 Jan 15;71(2):318-27
Cancer research 2011 Jan 15;71(2):318-27
Analysis of circulating regulatory T cells in patients with metastatic prostate cancer pre- versus post-vaccination.
Vergati M, Cereda V, Madan RA, Gulley JL, Huen NY, Rogers CJ, Hance KW, Arlen PM, Schlom J, Tsang KY
Cancer immunology, immunotherapy : CII 2011 Feb;60(2):197-206
Cancer immunology, immunotherapy : CII 2011 Feb;60(2):197-206
The human cytomegalovirus UL11 protein interacts with the receptor tyrosine phosphatase CD45, resulting in functional paralysis of T cells.
Gabaev I, Steinbrück L, Pokoyski C, Pich A, Stanton RJ, Schwinzer R, Schulz TF, Jacobs R, Messerle M, Kay-Fedorov PC
PLoS pathogens 2011 Dec;7(12):e1002432
PLoS pathogens 2011 Dec;7(12):e1002432
T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice.
Wiede F, Shields BJ, Chew SH, Kyparissoudis K, van Vliet C, Galic S, Tremblay ML, Russell SM, Godfrey DI, Tiganis T
The Journal of clinical investigation 2011 Dec;121(12):4758-74
The Journal of clinical investigation 2011 Dec;121(12):4758-74
Interleukin-2 and regulatory T cells in graft-versus-host disease.
Koreth J, Matsuoka K, Kim HT, McDonough SM, Bindra B, Alyea EP 3rd, Armand P, Cutler C, Ho VT, Treister NS, Bienfang DC, Prasad S, Tzachanis D, Joyce RM, Avigan DE, Antin JH, Ritz J, Soiffer RJ
The New England journal of medicine 2011 Dec 1;365(22):2055-66
The New England journal of medicine 2011 Dec 1;365(22):2055-66
Cofilin-mediated F-actin severing is regulated by the Rap GTPase and controls the cytoskeletal dynamics that drive lymphocyte spreading and BCR microcluster formation.
Freeman SA, Lei V, Dang-Lawson M, Mizuno K, Roskelley CD, Gold MR
Journal of immunology (Baltimore, Md. : 1950) 2011 Dec 1;187(11):5887-900
Journal of immunology (Baltimore, Md. : 1950) 2011 Dec 1;187(11):5887-900
Engineered artificial antigen presenting cells facilitate direct and efficient expansion of tumor infiltrating lymphocytes.
Ye Q, Loisiou M, Levine BL, Suhoski MM, Riley JL, June CH, Coukos G, Powell DJ Jr
Journal of translational medicine 2011 Aug 9;9:131
Journal of translational medicine 2011 Aug 9;9:131
Protein kinase Ctheta is a specific target for inhibition of the HIV type 1 replication in CD4+ T lymphocytes.
López-Huertas MR, Mateos E, Díaz-Gil G, Gómez-Esquer F, Sánchez del Cojo M, Alcamí J, Coiras M
The Journal of biological chemistry 2011 Aug 5;286(31):27363-77
The Journal of biological chemistry 2011 Aug 5;286(31):27363-77
Impairment of regulatory capacity of CD4+CD25+ regulatory T cells mediated by dendritic cell polarization and hyperthyroidism in Graves' disease.
Mao C, Wang S, Xiao Y, Xu J, Jiang Q, Jin M, Jiang X, Guo H, Ning G, Zhang Y
Journal of immunology (Baltimore, Md. : 1950) 2011 Apr 15;186(8):4734-43
Journal of immunology (Baltimore, Md. : 1950) 2011 Apr 15;186(8):4734-43
Enhanced suppressive function of regulatory T cells from patients with immune-mediated diseases following successful ex vivo expansion.
Cao T, Wenzel SE, Faubion WA, Harriman G, Li L
Clinical immunology (Orlando, Fla.) 2010 Sep;136(3):329-37
Clinical immunology (Orlando, Fla.) 2010 Sep;136(3):329-37
PD-1 on immature and PD-1 ligands on migratory human Langerhans cells regulate antigen-presenting cell activity.
Peña-Cruz V, McDonough SM, Diaz-Griffero F, Crum CP, Carrasco RD, Freeman GJ
The Journal of investigative dermatology 2010 Sep;130(9):2222-30
The Journal of investigative dermatology 2010 Sep;130(9):2222-30
CD277 is a negative co-stimulatory molecule universally expressed by ovarian cancer microenvironmental cells.
Cubillos-Ruiz JR, Martinez D, Scarlett UK, Rutkowski MR, Nesbeth YC, Camposeco-Jacobs AL, Conejo-Garcia JR
Oncotarget 2010 Sep;1(5):329-38
Oncotarget 2010 Sep;1(5):329-38
Inhibition of effector function but not T cell activation and increase in FoxP3 expression in T cells differentiated in the presence of PP14.
Ochanuna Z, Geiger-Maor A, Dembinsky-Vaknin A, Karussis D, Tykocinski ML, Rachmilewitz J
PloS one 2010 Sep 23;5(9):e12868
PloS one 2010 Sep 23;5(9):e12868
Modulation of cell signaling networks after CTLA4 blockade in patients with metastatic melanoma.
Comin-Anduix B, Sazegar H, Chodon T, Matsunaga D, Jalil J, von Euw E, Escuin-Ordinas H, Balderas R, Chmielowski B, Gomez-Navarro J, Koya RC, Ribas A
PloS one 2010 Sep 15;5(9):e12711
PloS one 2010 Sep 15;5(9):e12711
NF-kappaB inhibits T-cell activation-induced, p73-dependent cell death by induction of MDM2.
Busuttil V, Droin N, McCormick L, Bernassola F, Candi E, Melino G, Green DR
Proceedings of the National Academy of Sciences of the United States of America 2010 Oct 19;107(42):18061-6
Proceedings of the National Academy of Sciences of the United States of America 2010 Oct 19;107(42):18061-6
Anaphase-promoting complex/cyclosome-Cdh1 coordinates glycolysis and glutaminolysis with transition to S phase in human T lymphocytes.
Colombo SL, Palacios-Callender M, Frakich N, De Leon J, Schmitt CA, Boorn L, Davis N, Moncada S
Proceedings of the National Academy of Sciences of the United States of America 2010 Nov 2;107(44):18868-73
Proceedings of the National Academy of Sciences of the United States of America 2010 Nov 2;107(44):18868-73
Altered regulatory T cell homeostasis in patients with CD4+ lymphopenia following allogeneic hematopoietic stem cell transplantation.
Matsuoka K, Kim HT, McDonough S, Bascug G, Warshauer B, Koreth J, Cutler C, Ho VT, Alyea EP, Antin JH, Soiffer RJ, Ritz J
The Journal of clinical investigation 2010 May;120(5):1479-93
The Journal of clinical investigation 2010 May;120(5):1479-93
Fas ligand gene expression is directly regulated by stress-inducible heat shock transcription factor-1.
Bouchier-Hayes L, McBride S, van Geelen CM, Nance S, Lewis LK, Pinkoski MJ, Beere HM
Cell death and differentiation 2010 Jun;17(6):1034-46
Cell death and differentiation 2010 Jun;17(6):1034-46
Derivation of induced pluripotent stem cells from human peripheral blood T lymphocytes.
Brown ME, Rondon E, Rajesh D, Mack A, Lewis R, Feng X, Zitur LJ, Learish RD, Nuwaysir EF
PloS one 2010 Jun 29;5(6):e11373
PloS one 2010 Jun 29;5(6):e11373
Human tumor antigen-specific helper and regulatory T cells share common epitope specificity but exhibit distinct T cell repertoire.
Fourcade J, Sun Z, Kudela P, Janjic B, Kirkwood JM, El-Hafnawy T, Zarour HM
Journal of immunology (Baltimore, Md. : 1950) 2010 Jun 15;184(12):6709-18
Journal of immunology (Baltimore, Md. : 1950) 2010 Jun 15;184(12):6709-18
CD137 ligand signaling induces human monocyte to dendritic cell differentiation.
Kwajah M M S, Schwarz H
European journal of immunology 2010 Jul;40(7):1938-49
European journal of immunology 2010 Jul;40(7):1938-49
Adhesion and degranulation promoting adapter protein (ADAP) is a central hub for phosphotyrosine-mediated interactions in T cells.
Sylvester M, Kliche S, Lange S, Geithner S, Klemm C, Schlosser A, Grossmann A, Stelzl U, Schraven B, Krause E, Freund C
PloS one 2010 Jul 22;5(7):e11708
PloS one 2010 Jul 22;5(7):e11708
Effects of nilotinib on regulatory T cells: the dose matters.
Fei F, Yu Y, Schmitt A, Rojewski MT, Chen B, Greiner J, Götz M, Bunjes D, Schmitt M
Molecular cancer 2010 Jan 29;9:22
Molecular cancer 2010 Jan 29;9:22
Genome-wide analysis of allelic expression imbalance in human primary cells by high-throughput transcriptome resequencing.
Heap GA, Yang JH, Downes K, Healy BC, Hunt KA, Bockett N, Franke L, Dubois PC, Mein CA, Dobson RJ, Albert TJ, Rodesch MJ, Clayton DG, Todd JA, van Heel DA, Plagnol V
Human molecular genetics 2010 Jan 1;19(1):122-34
Human molecular genetics 2010 Jan 1;19(1):122-34
Polyfunctional T-cell responses are disrupted by the ovarian cancer ascites environment and only partially restored by clinically relevant cytokines.
Tran E, Nielsen JS, Wick DA, Ng AV, Johnson LD, Nesslinger NJ, McMurtrie E, Webb JR, Nelson BH
PloS one 2010 Dec 22;5(12):e15625
PloS one 2010 Dec 22;5(12):e15625
Human adenosine deaminase 2 induces differentiation of monocytes into macrophages and stimulates proliferation of T helper cells and macrophages.
Zavialov AV, Gracia E, Glaichenhaus N, Franco R, Zavialov AV, Lauvau G
Journal of leukocyte biology 2010 Aug;88(2):279-90
Journal of leukocyte biology 2010 Aug;88(2):279-90
T-cell receptor complex is essential for Fas signal transduction.
Akimzhanov AM, Wang X, Sun J, Boehning D
Proceedings of the National Academy of Sciences of the United States of America 2010 Aug 24;107(34):15105-10
Proceedings of the National Academy of Sciences of the United States of America 2010 Aug 24;107(34):15105-10
Role played by the programmed death-1-programmed death ligand pathway during innate immunity against Mycobacterium tuberculosis.
Alvarez IB, Pasquinelli V, Jurado JO, Abbate E, Musella RM, de la Barrera SS, García VE
The Journal of infectious diseases 2010 Aug 15;202(4):524-32
The Journal of infectious diseases 2010 Aug 15;202(4):524-32
Accumulation of foxp3+ T regulatory cells in draining lymph nodes correlates with disease progression and immune suppression in colorectal cancer patients.
Deng L, Zhang H, Luan Y, Zhang J, Xing Q, Dong S, Wu X, Liu M, Wang S
Clinical cancer research : an official journal of the American Association for Cancer Research 2010 Aug 15;16(16):4105-12
Clinical cancer research : an official journal of the American Association for Cancer Research 2010 Aug 15;16(16):4105-12
Androgen-regulated expression of arginase 1, arginase 2 and interleukin-8 in human prostate cancer.
Gannon PO, Godin-Ethier J, Hassler M, Delvoye N, Aversa M, Poisson AO, Péant B, Alam Fahmy M, Saad F, Lapointe R, Mes-Masson AM
PloS one 2010 Aug 11;5(8):e12107
PloS one 2010 Aug 11;5(8):e12107
A role for the transcription factor Helios in human CD4(+)CD25(+) regulatory T cells.
Getnet D, Grosso JF, Goldberg MV, Harris TJ, Yen HR, Bruno TC, Durham NM, Hipkiss EL, Pyle KJ, Wada S, Pan F, Pardoll DM, Drake CG
Molecular immunology 2010 Apr;47(7-8):1595-600
Molecular immunology 2010 Apr;47(7-8):1595-600
Selective inhibition of IDO1 effectively regulates mediators of antitumor immunity.
Liu X, Shin N, Koblish HK, Yang G, Wang Q, Wang K, Leffet L, Hansbury MJ, Thomas B, Rupar M, Waeltz P, Bowman KJ, Polam P, Sparks RB, Yue EW, Li Y, Wynn R, Fridman JS, Burn TC, Combs AP, Newton RC, Scherle PA
Blood 2010 Apr 29;115(17):3520-30
Blood 2010 Apr 29;115(17):3520-30
IL-7 and IL-21 are superior to IL-2 and IL-15 in promoting human T cell-mediated rejection of systemic lymphoma in immunodeficient mice.
Markley JC, Sadelain M
Blood 2010 Apr 29;115(17):3508-19
Blood 2010 Apr 29;115(17):3508-19
Human cytomegalovirus elicits fetal gammadelta T cell responses in utero.
Vermijlen D, Brouwer M, Donner C, Liesnard C, Tackoen M, Van Rysselberge M, Twité N, Goldman M, Marchant A, Willems F
The Journal of experimental medicine 2010 Apr 12;207(4):807-21
The Journal of experimental medicine 2010 Apr 12;207(4):807-21
Expression of the autoimmune susceptibility gene FcRL3 on human regulatory T cells is associated with dysfunction and high levels of programmed cell death-1.
Swainson LA, Mold JE, Bajpai UD, McCune JM
Journal of immunology (Baltimore, Md. : 1950) 2010 Apr 1;184(7):3639-47
Journal of immunology (Baltimore, Md. : 1950) 2010 Apr 1;184(7):3639-47
The adapter protein SLP-76 mediates "outside-in" integrin signaling and function in T cells.
Baker RG, Hsu CJ, Lee D, Jordan MS, Maltzman JS, Hammer DA, Baumgart T, Koretzky GA
Molecular and cellular biology 2009 Oct;29(20):5578-89
Molecular and cellular biology 2009 Oct;29(20):5578-89
Psychosocial adaptation and cellular immunity in breast cancer patients in the weeks after surgery: An exploratory study.
Blomberg BB, Alvarez JP, Diaz A, Romero MG, Lechner SC, Carver CS, Holley H, Antoni MH
Journal of psychosomatic research 2009 Nov;67(5):369-76
Journal of psychosomatic research 2009 Nov;67(5):369-76
CD69 gene is differentially regulated in T and B cells by evolutionarily conserved promoter-distal elements.
Vazquez BN, Laguna T, Carabana J, Krangel MS, Lauzurica P
Journal of immunology (Baltimore, Md. : 1950) 2009 Nov 15;183(10):6513-21
Journal of immunology (Baltimore, Md. : 1950) 2009 Nov 15;183(10):6513-21
Phosphorus overload and PTH induce aortic expression of Runx2 in experimental uraemia.
Graciolli FG, Neves KR, dos Reis LM, Graciolli RG, Noronha IL, Moysés RM, Jorgetti V
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2009 May;24(5):1416-21
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2009 May;24(5):1416-21
A2A adenosine receptor (AR) activation inhibits pro-inflammatory cytokine production by human CD4+ helper T cells and regulates Helicobacter-induced gastritis and bacterial persistence.
Alam MS, Kurtz CC, Wilson JM, Burnette BR, Wiznerowicz EB, Ross WG, Rieger JM, Figler RA, Linden J, Crowe SE, Ernst PB
Mucosal immunology 2009 May;2(3):232-42
Mucosal immunology 2009 May;2(3):232-42
Accumulation of raft lipids in T-cell plasma membrane domains engaged in TCR signalling.
Zech T, Ejsing CS, Gaus K, de Wet B, Shevchenko A, Simons K, Harder T
The EMBO journal 2009 Mar 4;28(5):466-76
The EMBO journal 2009 Mar 4;28(5):466-76
ESAT-6 inhibits production of IFN-gamma by Mycobacterium tuberculosis-responsive human T cells.
Wang X, Barnes PF, Dobos-Elder KM, Townsend JC, Chung YT, Shams H, Weis SE, Samten B
Journal of immunology (Baltimore, Md. : 1950) 2009 Mar 15;182(6):3668-77
Journal of immunology (Baltimore, Md. : 1950) 2009 Mar 15;182(6):3668-77
Parallel multi-time point cell stimulation and lysis on-chip for studying early signaling events in T cell activation.
Hirsch AM, Rivet CA, Zhang B, Kemp ML, Lu H
Lab on a chip 2009 Feb 21;9(4):536-44
Lab on a chip 2009 Feb 21;9(4):536-44
Brx mediates the response of lymphocytes to osmotic stress through the activation of NFAT5.
Kino T, Takatori H, Manoli I, Wang Y, Tiulpakov A, Blackman MR, Su YA, Chrousos GP, DeCherney AH, Segars JH
Science signaling 2009 Feb 10;2(57):ra5
Science signaling 2009 Feb 10;2(57):ra5
Uncoordinated 119 protein controls trafficking of Lck via the Rab11 endosome and is critical for immunological synapse formation.
Gorska MM, Liang Q, Karim Z, Alam R
Journal of immunology (Baltimore, Md. : 1950) 2009 Aug 1;183(3):1675-84
Journal of immunology (Baltimore, Md. : 1950) 2009 Aug 1;183(3):1675-84
A role for human skin-resident T cells in wound healing.
Toulon A, Breton L, Taylor KR, Tenenhaus M, Bhavsar D, Lanigan C, Rudolph R, Jameson J, Havran WL
The Journal of experimental medicine 2009 Apr 13;206(4):743-50
The Journal of experimental medicine 2009 Apr 13;206(4):743-50
Mature antigen-experienced T helper cells synthesize and secrete the B cell chemoattractant CXCL13 in the inflammatory environment of the rheumatoid joint.
Manzo A, Vitolo B, Humby F, Caporali R, Jarrossay D, Dell'accio F, Ciardelli L, Uguccioni M, Montecucco C, Pitzalis C
Arthritis and rheumatism 2008 Nov;58(11):3377-87
Arthritis and rheumatism 2008 Nov;58(11):3377-87
Functional implications of plasma membrane condensation for T cell activation.
Rentero C, Zech T, Quinn CM, Engelhardt K, Williamson D, Grewal T, Jessup W, Harder T, Gaus K
PloS one 2008 May 28;3(5):e2262
PloS one 2008 May 28;3(5):e2262
Dysfunctional CD4+,CD25+ regulatory T cells in untreated active systemic lupus erythematosus secondary to interferon-alpha-producing antigen-presenting cells.
Yan B, Ye S, Chen G, Kuang M, Shen N, Chen S
Arthritis and rheumatism 2008 Mar;58(3):801-12
Arthritis and rheumatism 2008 Mar;58(3):801-12
The blood-brain barrier induces differentiation of migrating monocytes into Th17-polarizing dendritic cells.
Ifergan I, Kébir H, Bernard M, Wosik K, Dodelet-Devillers A, Cayrol R, Arbour N, Prat A
Brain : a journal of neurology 2008 Mar;131(Pt 3):785-99
Brain : a journal of neurology 2008 Mar;131(Pt 3):785-99
Antigen presentation by human microvascular endothelial cells triggers ICAM-1-dependent transendothelial protrusion by, and fractalkine-dependent transendothelial migration of, effector memory CD4+ T cells.
Manes TD, Pober JS
Journal of immunology (Baltimore, Md. : 1950) 2008 Jun 15;180(12):8386-92
Journal of immunology (Baltimore, Md. : 1950) 2008 Jun 15;180(12):8386-92
Cell-type-specific tyrosine phosphorylation of the herpes simplex virus tegument protein VP11/12 encoded by gene UL46.
Zahariadis G, Wagner MJ, Doepker RC, Maciejko JM, Crider CM, Jerome KR, Smiley JR
Journal of virology 2008 Jul;82(13):6098-108
Journal of virology 2008 Jul;82(13):6098-108
LXR signaling couples sterol metabolism to proliferation in the acquired immune response.
Bensinger SJ, Bradley MN, Joseph SB, Zelcer N, Janssen EM, Hausner MA, Shih R, Parks JS, Edwards PA, Jamieson BD, Tontonoz P
Cell 2008 Jul 11;134(1):97-111
Cell 2008 Jul 11;134(1):97-111
High TCL1 expression and intact T-cell receptor signaling define a hyperproliferative subset of T-cell prolymphocytic leukemia.
Herling M, Patel KA, Teitell MA, Konopleva M, Ravandi F, Kobayashi R, Jones D
Blood 2008 Jan 1;111(1):328-37
Blood 2008 Jan 1;111(1):328-37
Establishment and characterization of a cell based artificial antigen-presenting cell for expansion and activation of CD8+ T cells ex vivo.
Gong W, Ji M, Cao Z, Wang L, Qian Y, Hu M, Qian L, Pan X
Cellular & molecular immunology 2008 Feb;5(1):47-53
Cellular & molecular immunology 2008 Feb;5(1):47-53
Enhanced functionality of CD4+CD25(high)FoxP3+ regulatory T cells in the peripheral blood of patients with prostate cancer.
Yokokawa J, Cereda V, Remondo C, Gulley JL, Arlen PM, Schlom J, Tsang KY
Clinical cancer research : an official journal of the American Association for Cancer Research 2008 Feb 15;14(4):1032-40
Clinical cancer research : an official journal of the American Association for Cancer Research 2008 Feb 15;14(4):1032-40
PILAR is a novel modulator of human T-cell expansion.
Huarte E, Cubillos-Ruiz JR, Nesbeth YC, Scarlett UK, Martinez DG, Engle XA, Rigby WF, Pioli PA, Guyre PM, Conejo-Garcia JR
Blood 2008 Aug 15;112(4):1259-68
Blood 2008 Aug 15;112(4):1259-68
HIV-induced type I interferon and tryptophan catabolism drive T cell dysfunction despite phenotypic activation.
Boasso A, Hardy AW, Anderson SA, Dolan MJ, Shearer GM
PloS one 2008 Aug 13;3(8):e2961
PloS one 2008 Aug 13;3(8):e2961
The immunomodulatory Pseudomonas aeruginosa signalling molecule N-(3-oxododecanoyl)-L-homoserine lactone enters mammalian cells in an unregulated fashion.
Ritchie AJ, Whittall C, Lazenby JJ, Chhabra SR, Pritchard DI, Cooley MA
Immunology and cell biology 2007 Nov-Dec;85(8):596-602
Immunology and cell biology 2007 Nov-Dec;85(8):596-602
Increased frequencies of CD4+ CD25(high) regulatory T cells in acute dengue infection.
Lühn K, Simmons CP, Moran E, Dung NT, Chau TN, Quyen NT, Thao le TT, Van Ngoc T, Dung NM, Wills B, Farrar J, McMichael AJ, Dong T, Rowland-Jones S
The Journal of experimental medicine 2007 May 14;204(5):979-85
The Journal of experimental medicine 2007 May 14;204(5):979-85
Human IL4I1 is a secreted L-phenylalanine oxidase expressed by mature dendritic cells that inhibits T-lymphocyte proliferation.
Boulland ML, Marquet J, Molinier-Frenkel V, Möller P, Guiter C, Lasoudris F, Copie-Bergman C, Baia M, Gaulard P, Leroy K, Castellano F
Blood 2007 Jul 1;110(1):220-7
Blood 2007 Jul 1;110(1):220-7
General strategy for decoration of enveloped viruses with functionally active lipid-modified cytokines.
Kueng HJ, Leb VM, Haiderer D, Raposo G, Thery C, Derdak SV, Schmetterer KG, Neunkirchner A, Sillaber C, Seed B, Pickl WF
Journal of virology 2007 Aug;81(16):8666-76
Journal of virology 2007 Aug;81(16):8666-76
Lipid raft targeting of hematopoietic protein tyrosine phosphatase by protein kinase C theta-mediated phosphorylation.
Nika K, Charvet C, Williams S, Tautz L, Bruckner S, Rahmouni S, Bottini N, Schoenberger SP, Baier G, Altman A, Mustelin T
Molecular and cellular biology 2006 Mar;26(5):1806-16
Molecular and cellular biology 2006 Mar;26(5):1806-16
Beta-agonists modulate T-cell functions via direct actions on type 1 and type 2 cells.
Loza MJ, Foster S, Peters SP, Penn RB
Blood 2006 Mar 1;107(5):2052-60
Blood 2006 Mar 1;107(5):2052-60
C1q and MBL, components of the innate immune system, influence monocyte cytokine expression.
Fraser DA, Bohlson SS, Jasinskiene N, Rawal N, Palmarini G, Ruiz S, Rochford R, Tenner AJ
Journal of leukocyte biology 2006 Jul;80(1):107-16
Journal of leukocyte biology 2006 Jul;80(1):107-16
Between adaptive and innate immunity: TLR4-mediated perforin production by CD28null T-helper cells in ankylosing spondylitis.
Raffeiner B, Dejaco C, Duftner C, Kullich W, Goldberger C, Vega SC, Keller M, Grubeck-Loebenstein B, Schirmer M
Arthritis research & therapy 2005;7(6):R1412-20
Arthritis research & therapy 2005;7(6):R1412-20
IL-8 responsiveness defines a subset of CD8 T cells poised to kill.
Hess C, Means TK, Autissier P, Woodberry T, Altfeld M, Addo MM, Frahm N, Brander C, Walker BD, Luster AD
Blood 2004 Dec 1;104(12):3463-71
Blood 2004 Dec 1;104(12):3463-71
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- Staining of normal human peripheral blood cells with 0.125 µg of Mouse IgG2a Isotype Control Purified (Product # 14-4724-82) (open histogram) or Anti-Human CD3 Purified (filled histogram) followed by Anti-Mouse IgG FITC (Product # 11-4011-85). Cells in the lymphocyte gate were used for analysis.
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- Figure 9 IL-6 produced by PBLs depleted for CD4 + , CD8 + , HLA-DR + or CD56 + /CD16 + cells. (A) Freshly purified PBLs stained for CD4, CD8, CD3, HLA-DR, CD16, CD56. Depletion controls for PBLs depleted for CD4 + , CD8 + , HLA-DR + or CD16 + /CD56 + cells. PBLs and depletions were stimulated for 7 days with combinations of IL-12 (4 ng/mL), IL-15 (10 ng/mL), IL-18 (40 ng/mL) and TL1A (100 ng/mL) and stained for CD4, CD8, CD3, HLA-DR, CD16 and CD56 expression. (B) IL-6 production after 7 days by PBLs and depletions stimulated with IL-12, IL-15, IL-18 and TL1A as described above. Error bars represent the SEM of two measurements. Statistically significant differences by t-test: *** = p
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- Figure 2. F-actin foci co-localize with TCR MC and not ICAM1. ( A ) Freshly isolated mouse AND CD4 T cells were incubated with lipid bilayer reconstituted with Alexa568 tagged anti-CD3 (TCR, red) and Alexa647-ICAM1 (blue), for 2 min at 37degC. Post incubation, cells were fixed and stained for F-actin using Alexa488-phalloidin (green), and imaged using TIRF microscopy. The region marked 1 in the 'merge' panel is magnified to clearly show the co-localization of actin foci with TCR-containing MCs. Lower panels: AND mouse CD4 T cell blasts exhibit F-actin enrichment at TCR MCs sites. AND mouse CD4 T cell blasts were labeled with Alexa568-H57 Fab (TCR), and incubated with bilayer reconstituted with MHCp and Alexa405-ICAM1 for 2 min at 37degC, fixed and stained for F-actin. Region marked 2 in the 'merge' image is further magnified to show the overlap between TCR and F-actin (arrows). The insets 1 and 2 in both MHC-activated and anti-CD3-activated mouse T cells are contrasted differently from the original 'merge' image to highlight the TCR and actin distribution. ( B ) Quantitation of the fraction of TCR or ICAM1 localized with F-actin foci. AND CD4 T blasts were incubated with antigen containing bilayer for 2 min, as described above and the images acquired were processed for colocalization assessment as described in 'Materials and methods' section. Each point represents fraction of total synaptic TCR or ICAM1 associated with F-actin foci in a
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- Figure 7 UC-MSCs transferred mitochondria to activate T cells. PBMCs from SLE patients were labeled with carboxyfluorescein succinimidyl amino ester (CFSE) and treated with anti-CD3/CD28 antibodies for two days. Then they were cocultured with UC-MSCs for 12 h, which had been prelabeled with respiratory mitochondrion specific probe Mitotracker Deep Red (MDR). PBMCs were cultured with UC-MSCs through transwell as control. Then PBMCs were stained with anti-CD3, anti-CD4, or anti-CD8 dye and detected for MDR fluorescence with flow cytometry. Fluorescence microscopy was carried out similarly with anti-CD3/28 stimulation for 12 h and then cocultured for 6 h. All experiments were performed in triplicate. (a) T cells (CD3 positive) rather than non-T cells (CD3 negative) got MDR staining. (b-d) T cells cultured with UC-MSCs directly rather than through transwell got transferred mitochondria ( n = 3). Arrows indicated transferred mitochondria within lymphocytes. * p < 0.05.
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- Figure 2 TL1A induces IL-6 and TNF-alpha. Freshly purified PBMCs were incubated with IL-12 (2 ng/mL), IL-15 (10 ng/mL), IL-18 (10 ng/mL), TL1A (100 ng/mL) and TL1AAb (1 ug/mL, blocking antibody). Extra IL-15 (2 ng/mL) was added on day 3. ( A ) After 6 days, supernatants were collected and different cytokines were measured by bead-based ELISA. Error bars represent the SEM of eight measurements. Statistically significant differences are indicated by ***(t-test, P
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- Figure 1--figure supplement 3. WASP silencing causes a reduction in F-actin foci. Mouse CD4 T cell blasts were electroporated with WASP siRNAs, or with non-targeting sequences (control). The extent of depletion of protein levels was estimated using western blots. ~40% of protein depletion was achieved using WASP siRNAs (relative densitometry value mentioned on top of gel lanes). Cells electroporated with WASP siRNA exhibited significantly fewer F-actin foci. AND T cell blasts electroporated with siRNA sequences, as described above, were incubated with bilayer containing anti-CD3 and ICAM1 for 2 min, followed with fixation and staining with Alexa488-phalloidin (left panels), and imaged using TIRF microscopy. The graphs show quantitation of total F-actin (right graph) or F-actin foci (left graph) per cell, in control or WASP siRNA-treated cells. n1 = 35, n2 = 60, p = 0.238 (right) , p = 0.0025 (left graph). DOI: http://dx.doi.org/
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- Figure 2--figure supplement 4. Lack of F-actin foci in the cSMAC of primary T cells and the Jurkat T cell line. AND CD4 T cell blasts were either incubated with bilayers containing Alexa568 tagged anti-CD3 and ICAM1 (far left panels) or were labeled with Alexa568-H57 Fab and incubated with MHCp/ICAM1 bilayers (center left panels), for 2 min. Cells were fixed and stained for F-actin using Alexa488-phalloidin (middle row, green) and visualized using spinning disc confocal microscopy. Each image is a maximum intensity projection of the bottom three planes that show high intensity signals from the bilayer. Note that TCR MCs (bottom row, red) in the F-actin depleted central zone of the cell (asterisk) exhibit no significant co-localization with actin foci. This phenomenon where central microclusters lack F-actin foci was observed in >90% cells exhibiting well-defined cSMAC (number of experiments >3). F-actin foci were not detected in Jurkat T cells (center right panel, and far right insets). Jurkat T cells were activated on bilayer containing Aexa568 tagged anti-CD3 (TCR, red, bottom row) and ICAM1 for 2 min and were fixed and stained with Alexa488-phalloidin (Actin, green, middle row). As highlighted in insets, visible F-actin enrichment is missing from the TCR MCs in these cells. Scale bars, 5 um (AND T cell) and 10 um (Jurkat T cell). DOI: http://dx.doi.org/
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- Figure 6--figure supplement 2. Effect of CK666 on TCR-induced Zap70 and PLCgamma phosphorylation in human T cells. Freshly purified human CD4 T cells were treated with DMSO (control) or CK666, and incubated with bilayer reconstituted with anti-CD3 and ICAM1 for 2 min, in presence of the inhibitor. Cells were then fixed and stained with Alexa488 phalloidin (Actin, green) and either of anti-phospho Zap70 (upper panels) or anti-phospho-PLCgamma1 (Lower panels) antibodies, and subsequently imaged using TIRFM. The graph represents phospho-Zap70 (upper graph) or phospho-PLCgamma1 levels at synapse, normalized to the mean value in control cells. For upper graph, n1 = 49 n2 = 47, p = 0.976; for the lower graph, n1 = 78, n2 = 67, p = 0.004. DOI: http://dx.doi.org/
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- Figure 6. Arp2/3 inhibition leads to defective TCR-distal signaling. ( A ) Formation of TCR MCs or CD45 exclusion does not require F-actin foci. AND CD4 T cell blasts labeled with Alexa568-H57 Fab (to assess TCR clustering), or Alexa488-CD45 Fab (for CD45 exclusion) at 40C, were then incubated with bilayers containing ICAM1 and MHCp for 2 min, fixed (to assess TCR clustering) or visualized live (for CD45 exclusion) using TIRF microscopy. The images were processed to assess TCR clustering, or CD45 and TCR colocalization using rank filter based filtering, as described in 'Materials and methods' section. For the bars showing TCR cluster intensities per cell, n1 = 45, n2 = 28, p = 0.6; for CD45 co-localization, n1 = 26, n2 = 13, p = 0.09 . ( B ) Phosphorylation of TCR-proximal molecule Zap70 is not reduced in the cells treated with CK666. T cells were treated with DMSO or CK666 for 10 min, then incubated with surface containing ICAM1/anti-CD3 for 3 min, and processed for Y319-phospho-Zap70 and imaged using TIRF. The images were quantified to obtain the synaptic levels phospho-Zap70, and plotted as normalized to mean value of the 'control' cells. In the graph shown here, n1 = 34, n2 = 38, p = 0.16 . ( C ) Synaptic phospho-PLCgamma1 levels are reduced in cells lacking F-actin foci. DMSO (control, top panel) or CK666 (bottom panel) treated AND CD4 T cell blasts were incubated with bilayer containing anti-CD3 and ICAM1 for 2 min, fixed and stained with Alexa488-ph
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- FIGURE 7: Evolution of lymphoblast membrane surface area during transendothelial migration and cell spreading. (A) Time lapse of a lymphoblast transmigrating between human aortic endothelial cells. Scale bar, 20 mum. Images were taken every 15 s. The projected surface area S proj is represented in yellow before (leftmost image) and after (rightmost image) transendothelial migration. The pore diameter, D pore , is estimated by taking the image in which the lymphoblast width is identical above and below the pore (yellow arrows). (B) D pore during transendothelial migration as a function of the lymphoblast's projected diameter before transendothelial migration (computed using D 0 = S proj /2pi, and D 0 is an equivalent diameter for a sphere whose projected area is S proj ). (C) Histogram of the duration of transmigration. The mean duration is 3 +- 2 min (mean +- SD). (D) Scanning electron microscopy images of lymphoblasts spreading on a substrate coated with anti-CD3 plus anti-CD28 activating antibodies. Scale bars, 100 mum, 20 mum, 10 mum (left to right). Yellow arrows indicate spread cells. (E) Boxplots of the apparent membrane surface area of T-lymphocytes under both passive (white-filled box) and active (blue-filled box) deformations. The bottom and top of the box indicate the 25th and 75th percentiles, respectively. Red plus signs indicate outliers. From left to right, resting T-lymphocytes initially (column 1, A 0 , n = 14) and at rupture (column 2, A *, n = 14) aspir
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- Figure 3. Relationship of F-actin foci to TCR engagement and TCR proximal signaling. ( A ) AND mouse CD4 T cell blasts were incubated with lipid bilayer containing Alexa405-ICAM1 and MHCp, or bilayer containing Alexa405-ICAM1 alone (ICAM1) at 37degC for 2 min. The cells were fixed and stained with Alexa488-phalloidin (Actin) and imaged using TIRF microscopy. The images in the right panel are reflection (interference reflection microscopy - IRM) images in the two conditions, showing cell-bilayer contact area. Actin images were further high-pass filtered using a rank-filter based subtraction method (see 'Materials and methods') to reveal spatially localized actin features within each cell, under both incubation conditions. The graph (top right) shows average intensity of actin features (F-actin foci) per cell. n1 = 31, n2 = 53, p < 0.0001 . The bottom graph shows foci induction in human CD4 T cells. Primary human CD4 T cells were incubated with bilayer containing Alexa405-ICAM1 alone, or both Alexa405-ICAM1 and Alexa568 tagged anti-CD3 at 37degC for 2 min, and were then fixed and stained for F-actin using Alexa488-phalloidin, for imaging using TIRF microscopy. The graph shows integrated intensity of actin spots per cell, each point on the graph represents a single cell. n1 = 117, n = 79, p < 0.0001 ( B ) Formation of TCR MC associated F-actin foci requires SFK signaling. AND T cell blasts were treated with PP2 for 10 min at 37degC and were labeled with Alexa568-H57 Fab. This
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- Figure 5. F-actin foci require activity of the Arp2/3 complex. ( A ) Arp2/3 complex is localized at TCR MCs. DMSO (Control, top) or CK666 treated-(bottom) AND mouse T cell blasts were labeled with Alexa568-H57 Fab and were incubated with bilayer containing ICAM1 and MHCp for 2 min at 37degC, and then fixed and immunostained with anti-Arp3 antibody. The TIRF images show relative distribution of Arp3 (left, green) and TCR (middle, red) in the TIRF plane. Note that while Arp3 distribution overlaps with MCs in control cells, MCs are significantly devoid of Arp3 in CK666-treated cells (areas from 'merge' panels further magnified in insets). The graph (far right) shows the fraction co-localization of total synaptic TCR with Arp3. n1 = 54, n2 = 41, p < 0.0001 . In this experiment, the mean intensity of Arp3 in synapse was 3.46 (+-0.022) x 10 6 for control cells, and 2.38 (+-0.015) x 10 6 for CK666 treated cells (data not shown), and it was repeated twice with similar results. ( B ) TCR MCs associated F-actin enrichment is generated by Arp2/3 complex activation. AND T cell blasts were treated with DMSO alone (control), or 100 muM CK666, or 100 muM blebbistatin for 10 min at 37degC, were labeled with Alexa568-H57 Fab (TCR, red), and incubated with Alexa405-ICAM1 (ICAM1, blue) and MHCp-containing bilayer in the presence of the specific inhibitors at 37degC for 2 min. Cells were subsequently fixed, stained with Alexa488-phalloidin and imaged using TIRF microscopy. Note that
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- Figure 7--figure supplement 1. ILP F-actin and signaling in T-EC immunological synapse is dependent on Arp2/3 activity. ( A ) Visualization of loss of F-actin in ILPs following CK666 treatment. T cells were incubated with membrane-YFP (green) expressing endothelial cells in the presence of DMSO (control, left) or CK666 (right) for 5 min, then fixed, permeabilized and stained with Alexa594-phalloidin ('Actin', pink). Note that F-actin rich protrusions are missing at the CK666-treated T cell interface. Scale bar, 5 um. ( B ) Loss of ILPs correlated with reduced phospho-HS1 at the T cell-endothelial cell synaptic interface. T cells were incubated with endothelial cell layer, as described in 'Materials and methods' for 5 min and were then fixed and stained with Alexa594-phalloidin ('Actin', green), phospho-HS1 (red) and anti-CD3 (blue). Cells were then imaged using confocal microscopy. The insets show single T cells marked in the 'Merge' image. Scale bar, 10 um. ( C ) The intensity of the indicated proteins was then analyzed in the synaptic plane without and with CK666 treatment. n1 = 58, n2 = 71, p1 = 0.031, p2, p3 < 0.0001 . DOI: http://dx.doi.org/
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- Figure 4 PEG-S-Fab can bind CEA on tumor cells and CD3 + on T cells. Notes: Flow cytometry analysis of PEG-S-Fab and S-Fab on CEA-positive LS174T cells ( A ), CEA-negative SKOV3 cells ( B ), and CD3 + T cells ( C ). The positive control anti-CD3 antibody OKT3 was used for T-cell flow cytometry. Confocal microscopy of immunofluorescence staining as described in the ""Materials and methods"" section. S-Fab ( D ) and PEG-S-Fab ( E ) on LS174T cells (upper panel) and SKOV3 cells (lower panel), respectively. The scale bar represents 30 mum. AF488, stained by the goat antihuman IgG (H + L)-AlexaFluor 488 antibody; LS174T, human colorectal cell line LS174T; SKOV3, human ovarian cancer cell line SKOV3. Abbreviations: CEA, carcinoembryonic antigen; DAPI, 4',6-diamidino-2-phenylindole; IgG, immunoglobulin G; PEG, polyethylene glycol; PEG-S-Fab, PEGylated S-Fab; S-Fab, single-domain antibody-linked Fab; FITC, fluoresceine isothiocyanate.
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- Figure 4 The expression of galectin-1 in HSCs promotes HSC-induced T cell apoptosis and Th1/Th2 cytokine balance skewing A. Flow cytometry (annexin V-FITC apoptosis detection) analyses to detect T cell apoptosis in CD3+ T cells, cultured alone or co-cultured with HSCs subjected to different pre-treatments (cell transfection for galectin-1 knockdown and overexpression: sh-3 group versus Scr group; Over group versus pcDNA3.1 group) for 48 hours at a ratio of 10:1 (T:HSC), B. ELISA showing the levels of cytokines (IFN-gamma and IL-10) in the supernatant. Data are shown as the means (+- SD) of triplicates (n = 7). *P < 0.05. NC, negative control group; Scr, non-targeting scrambled sequence group; sh, small hairpin RNA sequence transfection group; pcDNA3.1, negative control group; Over, galectin-1 overexpression group; No HSCs, T cells cultured alone.
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- Figure 2 Cell surface expression of SAIL in CLL, AML and MM patient samples and normal BMMC and PBMC controls. ( a ) Three CLL specimens analyzed by flow cytometry. CLL cells were identified as CD19/CD5 double-positive cells. The histograms present SAIL (filled) and isotype control (open) staining in the live-cell and the CLL population. ( b ) Flow cytometry analysis of three AML specimens. SAIL expression is assessed in live-cells, CD33-positive and CD34-positive cells. ( c ) Flow cytometry analysis of three MM specimens. CD38 high cells with CD56 expression were gated for MM cells. SAIL expression is assessed in the live-cell and the MM population. ( d and e ) Flow cytometry analysis of SAIL expression in BMMC ( d ) and PBMC ( e ) via co-staining with CD19, CD3, CD14, CD56, CD33, CD34 and a cocktail of lineage (LN) markers. Numbers in histograms are median-fluorescence-intensity fold-change values relative to the isotype control. Three and two representative examples are shown for the tumor and normal samples, respectively.
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- Figure 6 CD16 + monocytes promoted T-cell proliferation in SLE . CFSE-labeled CD4 + T cells isolated from freshly collected SLE blood or blood bank collected HC blood buffy coat were cocultured with CD16 + and CD16 - monocytes for 60 h in the presence of anti-CD3 (1 mug/mL) and anti-CD 28 (1 mug/mL) antibodies and M-CSF (50 ng/mL). CFSE histograms depicted the number of events ( y -axis) and the fluorescence intensity ( x -axis), with proliferating cells displaying a progressive loss in fluorescence intensity following cell division, indicative of proliferating cells. (A) Representative histogram plots from a patient with SLE displayed the frequencies of CFSE low T cells in monocyte/T-cell cocultures and T cells cultured alone. (B) Percentages of CFSE low T cells in CD4 + T cells after coculture with each monocyte subset from five healthy donors and six patients with SLE. (C) The percentage increase in CFSE low T cells in cocultures of monocytes and T cells compared with CD4 + T cells cultured alone was compared between five healthy individuals and six patients with SLE. Data were expressed as mean +- SD and analyzed by non-parametric paired t test and Mann-Whitney U test. * P < 0.05, ** P < 0.01; NS, no significance.