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antibody from antibodies-online
Targeting: LMNA
CMD1A, HGPS, LGMD1B, LMN1, LMNL1, MADA, PRO1
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- Antibody Data
- Antigen structure
- References [5]
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- Validations [0]
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- Product number
- ABIN350369 - Provider product page
- Provider
- antibodies-online
- Proper citation
- Antibodies-Online Cat#ABIN350369, RRID:AB_10785192
- Product name
- anti-Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) (Internal Region) antibody
- Antibody type
- Polyclonal
- Antigen
- A synthetic peptide from the internal region of human HIF1 alpha (HIF1A, MOP1, Hypoxia-inducible factor 1 alpha) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen shares 94% identity with rat and mouse sequences.
- Reactivity
- Human, Mouse, Rat
- Host
- Goat
- Epitope
- Internal Region
- Vial size
- 100 μL
- Storage
- Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability.
- Handling
- Avoid freeze and thaw cycles.
Submitted references Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL.
Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway.
Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway.
Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha. Modulation of transcriptional activity by oxygen tension.
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.
Hon WC, Wilson MI, Harlos K, Claridge TD, Schofield CJ, Pugh CW, Maxwell PH, Ratcliffe PJ, Stuart DI, Jones EY
Nature 2002 Jun 27;417(6892):975-8
Nature 2002 Jun 27;417(6892):975-8
Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway.
Huang LE, Gu J, Schau M, Bunn HF
Proceedings of the National Academy of Sciences of the United States of America 1998 Jul 7;95(14):7987-92
Proceedings of the National Academy of Sciences of the United States of America 1998 Jul 7;95(14):7987-92
Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway.
Hogenesch JB, Chan WK, Jackiw VH, Brown RC, Gu YZ, Pray-Grant M, Perdew GH, Bradfield CA
The Journal of biological chemistry 1997 Mar 28;272(13):8581-93
The Journal of biological chemistry 1997 Mar 28;272(13):8581-93
Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha. Modulation of transcriptional activity by oxygen tension.
Jiang BH, Zheng JZ, Leung SW, Roe R, Semenza GL
The Journal of biological chemistry 1997 Aug 1;272(31):19253-60
The Journal of biological chemistry 1997 Aug 1;272(31):19253-60
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.
Wang GL, Jiang BH, Rue EA, Semenza GL
Proceedings of the National Academy of Sciences of the United States of America 1995 Jun 6;92(12):5510-4
Proceedings of the National Academy of Sciences of the United States of America 1995 Jun 6;92(12):5510-4
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