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LearnTissue expression
Cell line expression
Protein structure
LMNA
Lamin A/CCMD1A, HGPS, LGMD1B, LMN1, LMNL1, MADA, PRO1
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, Apr 2012]
Top validated antibodies |
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| Proteintech Group |  10298-1-AP |
102 references | Polyclonal |
WB
EL
ICC
IP
FC
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| Invitrogen Antibodies | MA1-06101 |
4 references | Monoclonal |
WB
ICC
IHC
ChIP
OA
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| GeneTex | GTX101127 |
20 references | Polyclonal |
WB
ICC
IP
IHC
|
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| Novus Biologicals | NBP2-19324 |
1 references | Polyclonal |
WB
ICC
IP
IHC
|
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| OriGene | BM4500 |
1 references | Monoclonal |
WB
ICC
IHC
FC
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