LMNA

gene product
CMD1A, HGPS, LGMD1B, LMN1, LMNL1, PRO1
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, Apr 2012]
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Antibodypedia Validation Initiative

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Enhanced validation
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1380 antibodies from 45 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
GeneTex
21 antibodies
antibodies-online
525 antibodies
Invitrogen Antibodies
18 antibodies
Novus Biologicals
141 antibodies
Abnova Corporation
16 antibodies
Boster Biological Technology
3 antibodies
Cell Signaling Technology, Inc
11 antibodies
NovoPro Bioscience Inc.
13 antibodies
Proteintech Group
1 antibody
Biorbyt
73 antibodies