PA1103
antibody from Boster Biological Technology
Targeting: LMNA
CMD1A, HGPS, LGMD1B, LMN1, LMNL1, MADA, PRO1
Antibody data
- Antibody Data
- Antigen structure
- References [7]
- Comments [0]
- Validations
- Immunohistochemistry [1]
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- Product number
- PA1103 - Provider product page
- Provider
- Boster Biological Technology
- Product name
- Anti-Lamin A + C/LMNA Antibody
- Antibody type
- Polyclonal
- Description
- Polyclonal antibody for LAMIN A/LMNA detection. Host: Rabbit.Size: 100μg/vial. Tested applications: IHC-P. Reactive species: Human. LAMIN A/LMNA information: Molecular Weight: 74139 MW; Subcellular Localization: Nucleus. Nucleus envelope. Nucleus lamina. Nucleus, nucleoplasm. Farnesylation of prelamin-A/C facilitates nuclear envelope targeting and subsequent cleaveage by ZMPSTE24/FACE1 to remove the farnesyl group produces mature lamin- A/C, which can then be inserted into the nuclear lamina. EMD is required for proper localization of non-farnesylated prelamin-A/C; Tissue Specificity: In the arteries, prelamin-A/C accumulation is not observed in young healthy vessels but is prevalent in medial vascular smooth muscle cells (VSMCs) from aged individuals and in atherosclerotic lesions, where it often colocalizes with senescent and degenerate VSMCs. Prelamin-A/C expression increases with age and disease. In normal aging, the accumulation of prelamin-A/C is caused in part by the down-regulation of ZMPSTE24/FACE1 in response to oxidative stress.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Vial size
- 100μg/vial
- Concentration
- Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
- Storage
- At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquoted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.
- Handling
- Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Submitted references Polysaccharides from Polygonatum kingianum Collett & Hemsl ameliorated fatigue by regulating NRF2/HO-1/NQO1 and AMPK/PGC-1α/TFAM signaling pathways, and gut microbiota.
Innate immune receptors co-recognition of polysaccharides initiates multi-pathway synergistic immune response.
c-myc-mediated upregulation of NAT10 facilitates tumor development via cell cycle regulation in non-small cell lung cancer.
Involvement of NF-κB in the reversal of CYP3A down-regulation induced by sea buckthorn in BCG-induced rats.
NF-κB-mediated regulation of rat CYP2E1 by two independent signaling pathways.
Hyperhomocysteinemia Accelerates Acute Kidney Injury to Chronic Kidney Disease Progression by Downregulating Heme Oxygenase-1 Expression.
Loss of lamin A but not lamin C expression in epithelial ovarian cancer cells is associated with metastasis and poor prognosis.
Xu X, Shan M, Chu C, Bie S, Wang H, Cai S
International journal of biological macromolecules 2024 May;266(Pt 2):131440
International journal of biological macromolecules 2024 May;266(Pt 2):131440
Innate immune receptors co-recognition of polysaccharides initiates multi-pathway synergistic immune response.
Li M, Huang X, Wen J, Chen S, Wu X, Ma W, Cui SW, Xie M, Nie S
Carbohydrate polymers 2023 Apr 1;305:120533
Carbohydrate polymers 2023 Apr 1;305:120533
c-myc-mediated upregulation of NAT10 facilitates tumor development via cell cycle regulation in non-small cell lung cancer.
Wang Z, Huang Y, Lu W, Liu J, Li X, Zhu S, Liu H, Song Y
Medical oncology (Northwood, London, England) 2022 Jul 14;39(10):140
Medical oncology (Northwood, London, England) 2022 Jul 14;39(10):140
Involvement of NF-κB in the reversal of CYP3A down-regulation induced by sea buckthorn in BCG-induced rats.
Liu F, Wang T, Li X, Jia J, Lin Q, Xue Y
PloS one 2020;15(9):e0238810
PloS one 2020;15(9):e0238810
NF-κB-mediated regulation of rat CYP2E1 by two independent signaling pathways.
Lin Q, Kang X, Li X, Wang T, Liu F, Jia J, Jin Z, Xue Y
PloS one 2019;14(12):e0225531
PloS one 2019;14(12):e0225531
Hyperhomocysteinemia Accelerates Acute Kidney Injury to Chronic Kidney Disease Progression by Downregulating Heme Oxygenase-1 Expression.
Li S, Qiu B, Lu H, Lai Y, Liu J, Luo J, Zhu F, Hu Z, Zhou M, Tian J, Zhou Z, Yu S, Yi F, Nie J
Antioxidants & redox signaling 2019 May 1;30(13):1635-1650
Antioxidants & redox signaling 2019 May 1;30(13):1635-1650
Loss of lamin A but not lamin C expression in epithelial ovarian cancer cells is associated with metastasis and poor prognosis.
Gong G, Chen P, Li L, Tan H, Zhou J, Zhou Y, Yang X, Wu X
Pathology, research and practice 2015 Feb;211(2):175-82
Pathology, research and practice 2015 Feb;211(2):175-82
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Supportive validation
- Submitted by
- Boster Biological Technology (provider)
- Main image
- Experimental details
- Anti-Lamin A+C antibody, PA1103, IHC(P)IHC(P): Human Lung Cancer Tissue
- Additional image