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- Antibody Data
- Antigen structure
- References [10]
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- Product number
- ABIN350817 - Provider product page
- Provider
- antibodies-online
- Proper citation
- Antibodies-Online Cat#ABIN350817, RRID:AB_10786374
- Product name
- anti-Runt-Related Transcription Factor 1 (RUNX1) (Internal Region) antibody
- Antibody type
- Polyclonal
- Antigen
- A synthetic peptide from the internal region of human Runt-related transcription factor 1 (Runx1, AML1, CBFA2) conjugated to an immunogenic carrier protein was used as the antigen.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Epitope
- Internal Region
- Vial size
- 100 μL
- Storage
- Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability.
- Handling
- Avoid freeze and thaw cycles.
Submitted references The RUNX1 Runt domain at 1.25A resolution: a structural switch and specifically bound chloride ions modulate DNA binding.
Structural analyses of DNA recognition by the AML1/Runx-1 Runt domain and its allosteric control by CBFbeta.
A novel transcript encoding an N-terminally truncated AML1/PEBP2 alphaB protein interferes with transactivation and blocks granulocytic differentiation of 32Dcl3 myeloid cells.
Expression of the human acute myeloid leukemia gene AML1 is regulated by two promoter regions.
AML1, AML2, and AML3, the human members of the runt domain gene-family: cDNA structure, expression, and chromosomal localization.
AML1 is expressed in skeletal muscle and is regulated by innervation.
Involvement of the AML1 gene in the t(3;21) in therapy-related leukemia and in chronic myeloid leukemia in blast crisis.
Isolation of PEBP2 alpha B cDNA representing the mouse homolog of human acute myeloid leukemia gene, AML1.
Leukaemia/Drosophila homology.
t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1.
Bäckström S, Wolf-Watz M, Grundström C, Härd T, Grundström T, Sauer UH
Journal of molecular biology 2002 Sep 13;322(2):259-72
Journal of molecular biology 2002 Sep 13;322(2):259-72
Structural analyses of DNA recognition by the AML1/Runx-1 Runt domain and its allosteric control by CBFbeta.
Tahirov TH, Inoue-Bungo T, Morii H, Fujikawa A, Sasaki M, Kimura K, Shiina M, Sato K, Kumasaka T, Yamamoto M, Ishii S, Ogata K
Cell 2001 Mar 9;104(5):755-67
Cell 2001 Mar 9;104(5):755-67
A novel transcript encoding an N-terminally truncated AML1/PEBP2 alphaB protein interferes with transactivation and blocks granulocytic differentiation of 32Dcl3 myeloid cells.
Zhang YW, Bae SC, Huang G, Fu YX, Lu J, Ahn MY, Kanno Y, Kanno T, Ito Y
Molecular and cellular biology 1997 Jul;17(7):4133-45
Molecular and cellular biology 1997 Jul;17(7):4133-45
Expression of the human acute myeloid leukemia gene AML1 is regulated by two promoter regions.
Ghozi MC, Bernstein Y, Negreanu V, Levanon D, Groner Y
Proceedings of the National Academy of Sciences of the United States of America 1996 Mar 5;93(5):1935-40
Proceedings of the National Academy of Sciences of the United States of America 1996 Mar 5;93(5):1935-40
AML1, AML2, and AML3, the human members of the runt domain gene-family: cDNA structure, expression, and chromosomal localization.
Levanon D, Negreanu V, Bernstein Y, Bar-Am I, Avivi L, Groner Y
Genomics 1994 Sep 15;23(2):425-32
Genomics 1994 Sep 15;23(2):425-32
AML1 is expressed in skeletal muscle and is regulated by innervation.
Zhu X, Yeadon JE, Burden SJ
Molecular and cellular biology 1994 Dec;14(12):8051-7
Molecular and cellular biology 1994 Dec;14(12):8051-7
Involvement of the AML1 gene in the t(3;21) in therapy-related leukemia and in chronic myeloid leukemia in blast crisis.
Nucifora G, Birn DJ, Espinosa R 3rd, Erickson P, LeBeau MM, Roulston D, McKeithan TW, Drabkin H, Rowley JD
Blood 1993 May 15;81(10):2728-34
Blood 1993 May 15;81(10):2728-34
Isolation of PEBP2 alpha B cDNA representing the mouse homolog of human acute myeloid leukemia gene, AML1.
Bae SC, Yamaguchi-Iwai Y, Ogawa E, Maruyama M, Inuzuka M, Kagoshima H, Shigesada K, Satake M, Ito Y
Oncogene 1993 Mar;8(3):809-14
Oncogene 1993 Mar;8(3):809-14
Leukaemia/Drosophila homology.
Daga A, Tighe JE, Calabi F
Nature 1992 Apr 9;356(6369):484
Nature 1992 Apr 9;356(6369):484
t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1.
Miyoshi H, Shimizu K, Kozu T, Maseki N, Kaneko Y, Ohki M
Proceedings of the National Academy of Sciences of the United States of America 1991 Dec 1;88(23):10431-4
Proceedings of the National Academy of Sciences of the United States of America 1991 Dec 1;88(23):10431-4
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