KCNMB1

MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the product of this gene, the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. [provided by RefSeq, Jul 2008]

Description

Potassium calcium-activated channel subfamily M regulatory beta subunit 1

Tissue specificity

Tissue enhanced (endometrium , intestine, seminal vesicle, smooth muscle)

Predicted location

Membrane

Protein family

FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Kim et al 2014)
Transporters

Chromosome

5 (170374671 - 170389634)

Ensembl ID

ENSG00000145936  (ver. 103.38)

Orthologs

Mouse Kcnmb1: ENSMUSG00000020155

UniProt

Q16558

neXtProt

NX_Q16558

Human splice variants
Mouse splice variants

Protein structure