TAF1C

Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the largest SL1-specific TAF. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2011]

Description

TATA-box binding protein associated factor, RNA polymerase I subunit C

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Nucleoli fibrillar center

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

16 (84177847 - 84187070)

Ensembl ID

ENSG00000103168  (ver. 103.38)

Orthologs

Mouse Taf1c: ENSMUSG00000031832

UniProt

Q15572

neXtProt

NX_Q15572

Human splice variants
Mouse splice variants

Protein structure