10392-1-AP

antibody from Proteintech Group

Targeting: USP2 UBP41

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

10392-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#10392-1-AP, RRID:AB_2212432

Product name

USP2 antibody

Antibody type

Polyclonal

Description

USP2 antibody (Cat. #10392-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Exploring the prognostic molecular mechanisms of medulloblastoma through methylation-transcriptome integration.

Tuerxun K, Ji W, Tukebai T, Liu D, Zhao J, Wang Y
SAGE open medicine 2026;14:20503121251386139

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Downregulation of B7-H4 contributes to the synergistic effect of USP2a-targeted/anti-PD-1 combination therapy in EGFR mutant lung cancer.

Sun B, Kong M, Jiang X, Zhu L, Zhang J, Tan L, Wang C, Yuan Z, Chen S, Wang C, Jiang Y, Zhang L
Cancer immunology, immunotherapy : CII 2026 Mar 26;75(4)

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USP2 Attenuates Spermatogenic Cell Apoptosis Via PINK1/Parkin-Dependent Mitophagy in Varicocoele: A Functional Study.

Yao RJ, Xiao H, Zheng JH, Lin B, Liao SJ, He HH, Xu N, Zhou HL
Andrology 2026 Apr 10;

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The deubiquitinase USP2 preserves intestinal barrier through the TRAF6/NF-κB/MLCK/MLC signaling in ulcerative colitis.

Zhou R, Cui Y, Wang W, Qu Y, Zhang G, Wang X, Sun Y, Li J
International immunopharmacology 2025 Sep 23;162:115099

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IL27RA promotes the proliferation and metastasis of hepatocellular carcinoma cells by regulating TGFβR1.

Zhang Y, Wu Y, Zhang Q, Xiong J, Xiao B, Zuo S
Scientific reports 2025 Oct 30;15(1):37959

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KAZN methylation as a potential diagnostic and prognostic marker in non-small cell lung cancer.

Zhu S, He Y, Wang W, Jiao Y, Xu Z, You S, Yu C, Ao J, Long M, Ren J, Zhang H, Liu SL, Bao H, Wang S
iScience 2025 Oct 17;28(10):113585

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USP2-mediated PPARγ stabilization promotes hepatocellular carcinoma progression and M2 macrophage polarization via oleic acid.

Cao J, Chen K, Hu K, Mi X, Pan Y, Xiao D, Liu S, Xiao L, Zhou L, Tao Y, Tang J
Journal for immunotherapy of cancer 2025 Nov 4;13(11)

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Lactate orchestrates the TGFβ pathway and ferroptosis nexus in organ fibrosis via USP2 lactylation.

Xiang J, Yang G, Li L, Liao T, Li Y, Liu X, Kang L, Wang X, Yang S, Liang Z
Communications biology 2025 Nov 28;8(1):1855

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USP41 plays carcinogenic roles in human cutaneous melanoma through PI3K/Akt signaling pathway.

Shen C, Wang X, Gu L, Cui X, Zhu W, Wang Y, Zhang X, Chen X
Archives of dermatological research 2025 May 20;317(1):768

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Deubiquitinating Enzyme USP2 Alleviates Muscle Atrophy by Stabilizing PPAR-γ.

Yang S, Xiong L, Liao T, Li L, Li Y, Kang L, Yang G, Liang Z
Diabetes 2025 May 1;74(5):773-786

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Targeting USP2 induces degradation of PML-RARα with or without drug-resistant mutations in acute promyelocytic leukemia.

Zhang J, Wu W, Wang Y, Zhang Y, Wang Y, Bai W, Zhang Z, Zhu C, Wu Y, Zhang Z, Yang L, Lei H, Xu H, Zhou L, Wu Y
Acta biochimica et biophysica Sinica 2025 Aug 11;58(3):574-83

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USP2-induced upregulation of LEF1 through deubiquitination relieves osteoporosis development by promoting the osteogenic differentiation of bone marrow mesenchymal stem cells.

Zhang Z, Cao J, Xing H, Liu J, Li L, Zhang Y
Journal of orthopaedic surgery and research 2025 Apr 29;20(1):430

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High dietary Fructose Drives Metabolic Dysfunction-Associated Steatotic Liver Disease via Activating ubiquitin-specific peptidase 2/11β-hydroxysteroid dehydrogenase type 1 Pathway in Mice.

Li C, Li M, Sheng W, Zhou W, Zhang Z, Ji G, Zhang L
International journal of biological sciences 2024;20(9):3480-3496

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Dual Inhibition of CDK4/6 and XPO1 Induces Senescence With Acquired Vulnerability to CRBN-Based PROTAC Drugs.

Wang H, Yuan S, Zheng Q, Zhang S, Zhang Q, Ji S, Wang W, Cao Y, Guo Y, Yang X, Geng H, Yang F, Xi S, Jin G, Zhang J, Gao Q, Bernards R, Qin W, Wang C
Gastroenterology 2024 Jun;166(6):1130-1144.e8

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Stress granule-localized USP8 potentiates cGAS-mediated type I interferonopathies through deubiquitination of DDX3X.

Zhang X, Han L, Hou J, Yang H, Xu H, Li G, Shu Q, Zhu D, Zheng Y, Gao C
Cell reports 2024 Jun 25;43(6):114248

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Identification of USP2 as a novel target to induce degradation of KRAS in myeloma cells.

Wang Y, Zhang Y, Luo H, Wei W, Liu W, Wang W, Wu Y, Peng C, Ji Y, Zhang J, Zhu C, Bai W, Xia L, Lei H, Xu H, Yin L, Weng W, Yang L, Liu L, Zhou A, Wei Y, Zhu Q, Zhu W, Yang Y, Xu Z, Wu Y
Acta pharmaceutica Sinica. B 2024 Dec;14(12):5235-5248

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The deubiquitinase USP2a promotes tumor immunosuppression by stabilizing immune checkpoint B7-H4 in lung adenocarcinoma harboring EGFR-activating mutants.

Lu Y, Sun Y, Zhang J, Kong M, Zhao Z, Sun B, Wang Y, Jiang Y, Chen S, Wang C, Tong Y, Wen L, Huang M, Wu F, Zhang L
Cancer letters 2024 Aug 1;596:217020

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USP2 promotes cell proliferation and metastasis in choroidal melanoma via stabilizing Snail.

Wei C, Zhao X, Zhang H, Wang L
Journal of cancer research and clinical oncology 2023 Sep;149(11):9263-9276

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In Cerebellar Atrophy of 12-Month-Old ATM-Null Mice, Transcriptome Upregulations Concern Most Neurotransmission and Neuropeptide Pathways, While Downregulations Affect Prominently Itpr1, Usp2 and Non-Coding RNA.

Reichlmeir M, Canet-Pons J, Koepf G, Nurieva W, Duecker RP, Doering C, Abell K, Key J, Stokes MP, Zielen S, Schubert R, Ivics Z, Auburger G
Cells 2023 Oct 3;12(19)

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Oncogenic KRAS effector USP13 promotes metastasis in non-small cell lung cancer through deubiquitinating β-catenin.

Guo Y, Tian J, Guo Y, Wang C, Chen C, Cai S, Yu W, Sun B, Yan J, Li Z, Fan J, Qi Q, Zhang D, Jin W, Hua Z, Chen G
Cell reports 2023 Dec 26;42(12):113511

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Derepression of the USP22-FASN axis by p53 loss under oxidative stress drives lipogenesis and tumorigenesis.

Han Z, Liu M, Xie Y, Zeng K, Zhan Z, Chen Y, Wang L, Chen X, Luo Y, Zeng Y, Zhan H, Lin Y, Zhang K, Zhu X, Liu S, Luo X, Zhou A
Cell death discovery 2022 Nov 4;8(1):445

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Ubiquitin-specific peptidase 2 inhibits epithelial-mesenchymal transition in clear cell renal cell carcinoma metastasis by downregulating the NF-κB pathway.

Duan J, Jin M, Yang D, Shi J, Gao J, Guo D, Tang H, Zhang S, Qiao B
Bioengineered 2022 Feb;13(2):4455-4467

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Ubiquitin-specific protease 2 regulates Ang Ⅱ-induced cardiac fibroblasts activation by up-regulating cyclin D1 and stabilizing β-catenin in vitro.

Xu Q, Liu M, Zhang F, Liu X, Ling S, Chen X, Gu J, Ou W, Liu S, Liu N
Journal of cellular and molecular medicine 2021 Jan;25(2):1001-1011

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Regulation of Bax-dependent apoptosis by mitochondrial deubiquitinase USP30.

Yan D, Li X, Yang Q, Huang Q, Yao L, Zhang P, Sun W, Lin S, Dou QP, Liu J, Chen X
Cell death discovery 2021 Aug 11;7(1):211

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Overexpression of Ubiquitin-Specific Protease 2 (USP2) in the Heart Suppressed Pressure Overload-Induced Cardiac Remodeling.

Xing J, Li P, Hong J, Wang M, Liu Y, Gao Y, Dong J, Gu H, Li L
Mediators of inflammation 2020;2020:4121750

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Inhibition of USP2 eliminates cancer stem cells and enhances TNBC responsiveness to chemotherapy.

He J, Lee HJ, Saha S, Ruan D, Guo H, Chan CH
Cell death & disease 2019 Mar 28;10(4):285

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3,3'-Diindolylmethane suppresses high-fat diet-induced obesity through inhibiting adipogenesis of pre-adipocytes by targeting USP2 activity.

Yang H, Seo SG, Shin SH, Min S, Kang MJ, Yoo R, Kwon JY, Yue S, Kim KH, Cheng JX, Kim JR, Park JS, Kim JH, Park JHY, Lee HJ, Lee KW
Molecular nutrition & food research 2017 Oct;61(10)

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CMP-Neu5Ac Hydroxylase Null Mice as a Model for Studying Metabolic Disorders Caused by the Evolutionary Loss of Neu5Gc in Humans.

Kwon DN, Choi YJ, Cho SG, Park C, Seo HG, Song H, Kim JH
BioMed research international 2015;2015:830315

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USP2 promotes cell migration and invasion in triple negative breast cancer cell lines.

Qu Q, Mao Y, Xiao G, Fei X, Wang J, Zhang Y, Liu J, Cheng G, Chen X, Wang J, Shen K
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2015 Jul;36(7):5415-23

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Ubiquitin-specific protease 2-69 in macrophages potentially modulates metainflammation.

Kitamura H, Kimura S, Shimamoto Y, Okabe J, Ito M, Miyamoto T, Naoe Y, Kikuguchi C, Meek B, Toda C, Okamoto S, Kanehira K, Hase K, Watarai H, Ishizuka M, El-Osta A, Ohara O, Miyoshi I
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013 Dec;27(12):4940-53

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Expression of USP2-69 in mesangial cells in vivo and in vitro.

Wang S, Wu H, Liu Y, Sun J, Zhao Z, Chen Q, Guo M, Ma D, Zhang Z
Pathology international 2010 Mar;60(3):184-92

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

mouse brain tissue were subjected to SDS PAGE followed by western blot with 10392-1-AP(USP2 antibody) at dilution of 1:500

Sample type

tissue

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human breast cancer using 10392-1-AP(USP2 antibody) at dilution of 1:50 (under 10x lens)

Sample type

tissue

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

The USP2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human USP2. This antibody recognizes human, mouse, rat antigen. The USP2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.

Appendix

10392-1-AP.pdf

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