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- References [16]
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- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 10392-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10392-1-AP, RRID:AB_2212432
- Product name
- USP2 antibody
- Antibody type
- Polyclonal
- Description
- USP2 antibody (Cat. #10392-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Dual Inhibition of CDK4/6 and XPO1 Induces Senescence With Acquired Vulnerability to CRBN-Based PROTAC Drugs.
The deubiquitinase USP2a promotes tumor immunosuppression by stabilizing immune checkpoint B7-H4 in lung adenocarcinoma harboring EGFR-activating mutants.
USP2 promotes cell proliferation and metastasis in choroidal melanoma via stabilizing Snail.
In Cerebellar Atrophy of 12-Month-Old ATM-Null Mice, Transcriptome Upregulations Concern Most Neurotransmission and Neuropeptide Pathways, While Downregulations Affect Prominently Itpr1, Usp2 and Non-Coding RNA.
Oncogenic KRAS effector USP13 promotes metastasis in non-small cell lung cancer through deubiquitinating β-catenin.
Derepression of the USP22-FASN axis by p53 loss under oxidative stress drives lipogenesis and tumorigenesis.
Ubiquitin-specific peptidase 2 inhibits epithelial-mesenchymal transition in clear cell renal cell carcinoma metastasis by downregulating the NF-κB pathway.
Ubiquitin-specific protease 2 regulates Ang Ⅱ-induced cardiac fibroblasts activation by up-regulating cyclin D1 and stabilizing β-catenin in vitro.
Regulation of Bax-dependent apoptosis by mitochondrial deubiquitinase USP30.
Overexpression of Ubiquitin-Specific Protease 2 (USP2) in the Heart Suppressed Pressure Overload-Induced Cardiac Remodeling.
Inhibition of USP2 eliminates cancer stem cells and enhances TNBC responsiveness to chemotherapy.
3,3'-Diindolylmethane suppresses high-fat diet-induced obesity through inhibiting adipogenesis of pre-adipocytes by targeting USP2 activity.
CMP-Neu5Ac Hydroxylase Null Mice as a Model for Studying Metabolic Disorders Caused by the Evolutionary Loss of Neu5Gc in Humans.
USP2 promotes cell migration and invasion in triple negative breast cancer cell lines.
Ubiquitin-specific protease 2-69 in macrophages potentially modulates metainflammation.
Expression of USP2-69 in mesangial cells in vivo and in vitro.
Wang H, Yuan S, Zheng Q, Zhang S, Zhang Q, Ji S, Wang W, Cao Y, Guo Y, Yang X, Geng H, Yang F, Xi S, Jin G, Zhang J, Gao Q, Bernards R, Qin W, Wang C
Gastroenterology 2024 Jun;166(6):1130-1144.e8
Gastroenterology 2024 Jun;166(6):1130-1144.e8
The deubiquitinase USP2a promotes tumor immunosuppression by stabilizing immune checkpoint B7-H4 in lung adenocarcinoma harboring EGFR-activating mutants.
Lu Y, Sun Y, Zhang J, Kong M, Zhao Z, Sun B, Wang Y, Jiang Y, Chen S, Wang C, Tong Y, Wen L, Huang M, Wu F, Zhang L
Cancer letters 2024 Aug 1;596:217020
Cancer letters 2024 Aug 1;596:217020
USP2 promotes cell proliferation and metastasis in choroidal melanoma via stabilizing Snail.
Wei C, Zhao X, Zhang H, Wang L
Journal of cancer research and clinical oncology 2023 Sep;149(11):9263-9276
Journal of cancer research and clinical oncology 2023 Sep;149(11):9263-9276
In Cerebellar Atrophy of 12-Month-Old ATM-Null Mice, Transcriptome Upregulations Concern Most Neurotransmission and Neuropeptide Pathways, While Downregulations Affect Prominently Itpr1, Usp2 and Non-Coding RNA.
Reichlmeir M, Canet-Pons J, Koepf G, Nurieva W, Duecker RP, Doering C, Abell K, Key J, Stokes MP, Zielen S, Schubert R, Ivics Z, Auburger G
Cells 2023 Oct 3;12(19)
Cells 2023 Oct 3;12(19)
Oncogenic KRAS effector USP13 promotes metastasis in non-small cell lung cancer through deubiquitinating β-catenin.
Guo Y, Tian J, Guo Y, Wang C, Chen C, Cai S, Yu W, Sun B, Yan J, Li Z, Fan J, Qi Q, Zhang D, Jin W, Hua Z, Chen G
Cell reports 2023 Dec 26;42(12):113511
Cell reports 2023 Dec 26;42(12):113511
Derepression of the USP22-FASN axis by p53 loss under oxidative stress drives lipogenesis and tumorigenesis.
Han Z, Liu M, Xie Y, Zeng K, Zhan Z, Chen Y, Wang L, Chen X, Luo Y, Zeng Y, Zhan H, Lin Y, Zhang K, Zhu X, Liu S, Luo X, Zhou A
Cell death discovery 2022 Nov 4;8(1):445
Cell death discovery 2022 Nov 4;8(1):445
Ubiquitin-specific peptidase 2 inhibits epithelial-mesenchymal transition in clear cell renal cell carcinoma metastasis by downregulating the NF-κB pathway.
Duan J, Jin M, Yang D, Shi J, Gao J, Guo D, Tang H, Zhang S, Qiao B
Bioengineered 2022 Feb;13(2):4455-4467
Bioengineered 2022 Feb;13(2):4455-4467
Ubiquitin-specific protease 2 regulates Ang Ⅱ-induced cardiac fibroblasts activation by up-regulating cyclin D1 and stabilizing β-catenin in vitro.
Xu Q, Liu M, Zhang F, Liu X, Ling S, Chen X, Gu J, Ou W, Liu S, Liu N
Journal of cellular and molecular medicine 2021 Jan;25(2):1001-1011
Journal of cellular and molecular medicine 2021 Jan;25(2):1001-1011
Regulation of Bax-dependent apoptosis by mitochondrial deubiquitinase USP30.
Yan D, Li X, Yang Q, Huang Q, Yao L, Zhang P, Sun W, Lin S, Dou QP, Liu J, Chen X
Cell death discovery 2021 Aug 11;7(1):211
Cell death discovery 2021 Aug 11;7(1):211
Overexpression of Ubiquitin-Specific Protease 2 (USP2) in the Heart Suppressed Pressure Overload-Induced Cardiac Remodeling.
Xing J, Li P, Hong J, Wang M, Liu Y, Gao Y, Dong J, Gu H, Li L
Mediators of inflammation 2020;2020:4121750
Mediators of inflammation 2020;2020:4121750
Inhibition of USP2 eliminates cancer stem cells and enhances TNBC responsiveness to chemotherapy.
He J, Lee HJ, Saha S, Ruan D, Guo H, Chan CH
Cell death & disease 2019 Mar 28;10(4):285
Cell death & disease 2019 Mar 28;10(4):285
3,3'-Diindolylmethane suppresses high-fat diet-induced obesity through inhibiting adipogenesis of pre-adipocytes by targeting USP2 activity.
Yang H, Seo SG, Shin SH, Min S, Kang MJ, Yoo R, Kwon JY, Yue S, Kim KH, Cheng JX, Kim JR, Park JS, Kim JH, Park JHY, Lee HJ, Lee KW
Molecular nutrition & food research 2017 Oct;61(10)
Molecular nutrition & food research 2017 Oct;61(10)
CMP-Neu5Ac Hydroxylase Null Mice as a Model for Studying Metabolic Disorders Caused by the Evolutionary Loss of Neu5Gc in Humans.
Kwon DN, Choi YJ, Cho SG, Park C, Seo HG, Song H, Kim JH
BioMed research international 2015;2015:830315
BioMed research international 2015;2015:830315
USP2 promotes cell migration and invasion in triple negative breast cancer cell lines.
Qu Q, Mao Y, Xiao G, Fei X, Wang J, Zhang Y, Liu J, Cheng G, Chen X, Wang J, Shen K
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2015 Jul;36(7):5415-23
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2015 Jul;36(7):5415-23
Ubiquitin-specific protease 2-69 in macrophages potentially modulates metainflammation.
Kitamura H, Kimura S, Shimamoto Y, Okabe J, Ito M, Miyamoto T, Naoe Y, Kikuguchi C, Meek B, Toda C, Okamoto S, Kanehira K, Hase K, Watarai H, Ishizuka M, El-Osta A, Ohara O, Miyoshi I
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013 Dec;27(12):4940-53
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013 Dec;27(12):4940-53
Expression of USP2-69 in mesangial cells in vivo and in vitro.
Wang S, Wu H, Liu Y, Sun J, Zhao Z, Chen Q, Guo M, Ma D, Zhang Z
Pathology international 2010 Mar;60(3):184-92
Pathology international 2010 Mar;60(3):184-92
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse brain tissue were subjected to SDS PAGE followed by western blot with 10392-1-AP(USP2 antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human breast cancer using 10392-1-AP(USP2 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The USP2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human USP2. This antibody recognizes human, mouse, rat antigen. The USP2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
