USP2

This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

Description

Ubiquitin specific peptidase 2

Tissue specificity

Tissue enhanced (skeletal muscle, testis)

Subcell location

Plasma membrane, Cytosol

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins

Chromosome

11 (119355215 - 119381711)

Ensembl ID

ENSG00000036672  (ver. 103.38)

Orthologs

Mouse Usp2: ENSMUSG00000032010

UniProt

O75604

neXtProt

NX_O75604

Human splice variants
Mouse splice variants

Protein structure