Antibody data
- Antibody Data
- Antigen structure
- References [8]
- Comments [0]
- Validations
- Western blot [2]
- Immunohistochemistry [3]
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- Product number
- ABIN2850431 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Ubiquitin Specific Peptidase 2 (USP2) (AA 508-538), (C-Term) antibody
- Antibody type
- Polyclonal
- Description
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
- Reactivity
- Human
- Host
- Rabbit
- Epitope
- AA 508-538, C-Term
- Antibody clone number
- RB4417
- Vial size
- 80 μL
- Storage
- Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots.
- Handling
- Avoid freeze-thaw cycles.
Submitted references Ubiquitin-specific protease 2b negatively regulates IFN-β production and antiviral activity by targeting TANK-binding kinase 1.
USP2a protein deubiquitinates and stabilizes the circadian protein CRY1 in response to inflammatory signals.
Mice lacking the USP2 deubiquitinating enzyme have severe male subfertility associated with defects in fertilization and sperm motility.
Ubiquitin-specific protease 2-45 (Usp2-45) binds to epithelial Na+ channel (ENaC)-ubiquitylating enzyme Nedd4-2.
MdmX is a substrate for the deubiquitinating enzyme USP2a.
Suppression of cancer cell growth by promoting cyclin D1 degradation.
Retraction for D. R. Zweitzig, N. Shcherbik, and D. S. Haines: AAA ATPase P97 and adaptor UBXD1 suppress MDM2 ubiquitination and degradation and promote constitutive P53 turnover.
The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2.
Zhang L, Zhao X, Zhang M, Zhao W, Gao C
Journal of immunology (Baltimore, Md. : 1950) 2014 Sep 1;193(5):2230-7
Journal of immunology (Baltimore, Md. : 1950) 2014 Sep 1;193(5):2230-7
USP2a protein deubiquitinates and stabilizes the circadian protein CRY1 in response to inflammatory signals.
Tong X, Buelow K, Guha A, Rausch R, Yin L
The Journal of biological chemistry 2012 Jul 20;287(30):25280-91
The Journal of biological chemistry 2012 Jul 20;287(30):25280-91
Mice lacking the USP2 deubiquitinating enzyme have severe male subfertility associated with defects in fertilization and sperm motility.
Bedard N, Yang Y, Gregory M, Cyr DG, Suzuki J, Yu X, Chian RC, Hermo L, O'Flaherty C, Smith CE, Clarke HJ, Wing SS
Biology of reproduction 2011 Sep;85(3):594-604
Biology of reproduction 2011 Sep;85(3):594-604
Ubiquitin-specific protease 2-45 (Usp2-45) binds to epithelial Na+ channel (ENaC)-ubiquitylating enzyme Nedd4-2.
Oberfeld B, Ruffieux-Daidié D, Vitagliano JJ, Pos KM, Verrey F, Staub O
American journal of physiology. Renal physiology 2011 Jul;301(1):F189-96
American journal of physiology. Renal physiology 2011 Jul;301(1):F189-96
MdmX is a substrate for the deubiquitinating enzyme USP2a.
Allende-Vega N, Sparks A, Lane DP, Saville MK
Oncogene 2010 Jan 21;29(3):432-41
Oncogene 2010 Jan 21;29(3):432-41
Suppression of cancer cell growth by promoting cyclin D1 degradation.
Shan J, Zhao W, Gu W
Molecular cell 2009 Nov 13;36(3):469-76
Molecular cell 2009 Nov 13;36(3):469-76
Retraction for D. R. Zweitzig, N. Shcherbik, and D. S. Haines: AAA ATPase P97 and adaptor UBXD1 suppress MDM2 ubiquitination and degradation and promote constitutive P53 turnover.
Zweitzig DR, Shcherbik N, Haines DS
Molecular biology of the cell 2008 Nov;19(11):5029
Molecular biology of the cell 2008 Nov;19(11):5029
The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2.
Stevenson LF, Sparks A, Allende-Vega N, Xirodimas DP, Lane DP, Saville MK
The EMBO journal 2007 Feb 21;26(4):976-86
The EMBO journal 2007 Feb 21;26(4):976-86
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Supportive validation
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- IHC
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