16431-1-AP

antibody from Proteintech Group

Targeting: DLD DLDH, E3, GCSL, LAD, OGDC-E3

Provider product page for 16431-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [21]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [2]

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Product number: 16431-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#16431-1-AP, RRID:AB_2091888
Product name: DLD antibody
Antibody type: Polyclonal
Description: DLD antibody (Cat. #16431-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

DLD protein structure - 16431-1-AP shown in red.

Submitted references Clinical features and molecular landscape of cuproptosis signature-related molecular subtype in gastric cancer.

Chong W, Ren H, Chen H, Xu K, Zhu X, Liu Y, Sang Y, Li H, Liu J, Ye C, Shang L, Jing C, Li L
iMeta 2024 Jun;3(3):e190

Hypoxia induces mitochondrial protein lactylation to limit oxidative phosphorylation.

Mao Y, Zhang J, Zhou Q, He X, Zheng Z, Wei Y, Zhou K, Lin Y, Yu H, Zhang H, Zhou Y, Lin P, Wu B, Yuan Y, Zhao J, Xu W, Zhao S
Cell research 2024 Jan;34(1):13-30

Monocarboxylate transporter 4 deficiency enhances high-intensity interval training-induced metabolic adaptations in skeletal muscle.

Tamura Y, Jee E, Kouzaki K, Kotani T, Nakazato K
The Journal of physiology 2024 Apr;602(7):1313-1340

ITGB1-mediated molecular landscape and cuproptosis phenotype induced the worse prognosis in diffuse gastric cancer.

Zhu X, Chen H, Li H, Ren H, Ye C, Xu K, Liu J, Du F, Zhang Z, Liu Y, Xie X, Wang M, Ma T, Chong W, Shang L, Li L
Frontiers in oncology 2023;13:1115510

Branched-chain amino acids promote thrombocytopoiesis by activating mTOR signaling.

Jiang H, Zhang L, Yang M, Li G, Ding C, Xin M, Dai J, Sun X, Fan X, Sun H, Liu J, Xu Y
Journal of thrombosis and haemostasis : JTH 2023 Nov;21(11):3224-3235

Bioinformatics-Based Analysis of Key Genes in Steroid-Induced Osteonecrosis of the Femoral Head That Are Associated with Copper Metabolism.

Qi B, Li C, Cai X, Pu L, Guo M, Tang Z, Bu P, Xu Y
Biomedicines 2023 Mar 13;11(3)

Mitochondrial SENP2 regulates the assembly of SDH complex under metabolic stress.

Liu Y, Liu K, Thorne RF, Shi R, Zhang Q, Wu M, Liu L
Cell reports 2023 Feb 28;42(2):112041

Oxoglutarate dehydrogenase-like inhibits the progression of hepatocellular carcinoma by inducing DNA damage through non-canonical function.

Jiang X, Peng J, Xie Y, Xu Y, Liu Q, Cheng C, Yan P, Xu S, Wang Y, Zhang L, Li H, Li Y, Li B, Han J, Yu D
Cell death and differentiation 2023 Aug;30(8):1931-1942

Silencing of OGDHL promotes liver cancer metastasis by enhancing hypoxia inducible factor 1 α protein stability.

Dai W, Li Y, Sun W, Ji M, Bao R, Chen J, Xu S, Dai Y, Chen Y, Liu W, Ge C, Sun W, Mo W, Guo C, Xu X
Cancer science 2023 Apr;114(4):1309-1323

Aberrant methylmalonylation underlies methylmalonic acidemia and is attenuated by an engineered sirtuin.

Head PE, Myung S, Chen Y, Schneller JL, Wang C, Duncan N, Hoffman P, Chang D, Gebremariam A, Gucek M, Manoli I, Venditti CP
Science translational medicine 2022 May 25;14(646):eabn4772

Copper induces cell death by targeting lipoylated TCA cycle proteins.

Tsvetkov P, Coy S, Petrova B, Dreishpoon M, Verma A, Abdusamad M, Rossen J, Joesch-Cohen L, Humeidi R, Spangler RD, Eaton JK, Frenkel E, Kocak M, Corsello SM, Lutsenko S, Kanarek N, Santagata S, Golub TR
Science (New York, N.Y.) 2022 Mar 18;375(6586):1254-1261

Proteomic analysis reveals the heterogeneity of metabolic reprogramming in lacrimal gland tumors.

Yang J, Li Y, Gao W, Feng Y, He X, Ni H, Song X, Fan J
Experimental eye research 2022 Jun;219:109052

Beneficial effects of aloperine on inflammation and oxidative stress by suppressing necroptosis in lipopolysaccharide-induced acute lung injury mouse model.

Cui YR, Qu F, Zhong WJ, Yang HH, Zeng J, Huang JH, Liu J, Zhang MY, Zhou Y, Guan CX
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jun;100:154074

Mitochondrial FAD shortage in SLC25A32 deficiency affects folate-mediated one-carbon metabolism.

Peng MZ, Shao YX, Li XZ, Zhang KD, Cai YN, Lin YT, Jiang MY, Liu ZC, Su XY, Zhang W, Jiang XL, Liu L
Cellular and molecular life sciences : CMLS 2022 Jun 21;79(7):375

Blocking glycine utilization inhibits multiple myeloma progression by disrupting glutathione balance.

Xia J, Zhang J, Wu X, Du W, Zhu Y, Liu X, Liu Z, Meng B, Guo J, Yang Q, Wang Y, Wang Q, Feng X, Xie G, Shen Y, He Y, Xiang J, Wu M, An G, Qiu L, Jia W, Zhou W
Nature communications 2022 Jul 11;13(1):4007

Metabolon formation regulates branched-chain amino acid oxidation and homeostasis.

Patrick M, Gu Z, Zhang G, Wynn RM, Kaphle P, Cao H, Vu H, Cai F, Gao X, Zhang Y, Chen M, Ni M, Chuang DT, DeBerardinis RJ, Xu J
Nature metabolism 2022 Dec;4(12):1775-1791

Transketolase in human Müller cells is critical to resist light stress through the pentose phosphate and NRF2 pathways.

Chen Y, Zhang T, Zeng S, Xu R, Jin K, Coorey NJ, Wang Y, Wang K, Lee SR, Yam M, Zhu M, Chang A, Fan X, Zhang M, Du J, Gillies MC, Zhu L
Redox biology 2022 Aug;54:102379

OGDHL silencing promotes hepatocellular carcinoma by reprogramming glutamine metabolism.

Dai W, Xu L, Yu X, Zhang G, Guo H, Liu H, Song G, Weng S, Dong L, Zhu J, Liu T, Guo C, Shen X
Journal of hepatology 2020 May;72(5):909-923

Utilizing Optimized Tools to Investigate PTM Crosstalk: Identifying Potential PTM Crosstalk of Acetylated Mitochondrial Proteins.

Horita H, Law A, Middleton K
Proteomes 2018 May 22;6(2)

RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis.

Yang Z, Wang Y, Zhang Y, He X, Zhong CQ, Ni H, Chen X, Liang Y, Wu J, Zhao S, Zhou D, Han J
Nature cell biology 2018 Feb;20(2):186-197

Riboflavin responsive mitochondrial myopathy is a new phenotype of dihydrolipoamide dehydrogenase deficiency. The chaperon-like effect of vitamin B2.

Carrozzo R, Torraco A, Fiermonte G, Martinelli D, Di Nottia M, Rizza T, Vozza A, Verrigni D, Diodato D, Parisi G, Maiorana A, Rizzo C, Pierri CL, Zucano S, Piemonte F, Bertini E, Dionisi-Vici C
Mitochondrion 2014 Sep;18:49-57

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: human liver tissue were subjected to SDS PAGE followed by western blot with 16431-1-AP(DLD antibody) at dilution of 1:500
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human kidney using 16431-1-AP(DLD antibody) at dilution of 1:100 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The DLD antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human DLD. This antibody recognizes human,mouse,rat antigen. The DLD antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 16431-1-AP.pdf

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