USP20

gene product
KIAA1003
This gene encodes a ubiquitin specific processing protease that was first identified as a substrate of the VHL (von Hippel-Lindau disease) protein E3 ubiquitin ligase complex. In addition to being ubiquitinated by the VHL-E3 ligase complex, this enzyme deubiquitinates hypoxia-inducible factor (HIF)-1 alpha and thereby causes increased expression of HIF-1alpha targeted genes which play a role in angiogenesis, glucose metabolism, cell proliferation and metastasis. The enzyme encoded by this gene also regulates G-protein coupled receptor signaling by mediating the deubiquitination of beta-2 adrenergic receptor (ADRB2). This enzyme is a ubiquitously expressed thiolester hydrolase. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jan 2013]
More gene data

Featured antibodies

Antibodies

 

Filters

Antibodypedia Validation Initiative

Validation method

Application

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

  or   Clear
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Validated within AVI
Eligible for validation within AVI
263 antibodies from 28 providers.

Antibody properties

Applications

or Cancel
AntibodyRefsTypeAVIWBELICCIPIHCFC
Novus Biologicals
7 antibodies
NovoPro Bioscience Inc.
1 antibody
antibodies-online
95 antibodies
Proteintech Group
1 antibody
Biorbyt
9 antibodies
Antibodies.com
1 antibody
Abnova Corporation
9 antibodies
Aviva Systems Biology
4 antibodies
Atlas Antibodies
1 antibody
LifeSpan BioSciences, Inc.
53 antibodies
GeneTex
2 antibodies
ProSci
5 antibodies
Bethyl Laboratories
1 antibody
St John's Laboratory
1 antibody
Invitrogen Antibodies
4 antibodies
Arigo
1 antibody
Everest Biotech
1 antibody
NSJ Bioreagents
1 antibody
OriGene
5 antibodies
Acris Antibodies GmbH
3 antibodies
MyBioSource
9 antibodies
Sigma-Aldrich
7 antibodies
Creative Diagnostics
3 antibodies
United States Biological
31 antibodies
RayBiotech, Inc.
3 antibodies
Abgent
2 antibodies
Exalpha Biologicals, Inc.
2 antibodies
Creative Biolabs
1 antibody