ZFYVE27

This gene encodes a protein with several transmembrane domains, a Rab11-binding domain and a lipid-binding FYVE finger domain. The encoded protein appears to promote neurite formation. A mutation in this gene has been reported to be associated with hereditary spastic paraplegia, however the pathogenicity of the mutation, which may simply represent a polymorphism, is unclear. [provided by RefSeq, Mar 2010]

Description

zinc finger, FYVE domain containing 27

Protein family

Disease related genes, Mapped to UniProt SWISS-PROT, Predicted membrane proteins, Protein evidence (Ezkurdia et al 2014), Protein evidence (Kim et al 2014)

Chromosome

10:q24.2 (97737121 - 97760907)

Ensembl ID

ENSG00000155256  (ver. 84.38)

Orthologs

Mouse Zfyve27: ENSMUSG00000018820

UniProt

Q5T4F4

neXtProt

NX_Q5T4F4

Human splice variants
Mouse splice variants