Antibody data
- Antibody Data
- Antigen structure
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- Product number
- BS1296 - Provider product page
- Provider
- Bioworld Technology, Inc
- Proper citation
- Bioworld Technology Cat#BS1296, RRID:AB_1663695
- Product name
- PML (P39) polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Synthetic peptide, corresponding to the N-terminal of Human PML.
- Description
- The PML protein is a zinc finger transcription factor expressed as three major transcription products due to alternative splicing. The gene encoding human PML maps to chromosome 15q22. The t(15;17) (q22;q11.2-q12) chromosomal trans-location of the retinoic acid receptor Ï« (RARÏ«) gene occurs in virtually all cases of acute promyelocytic leukemia and results in the expression of a PML/RARÏ« chimeric protein. Myeloid precursor cells expressing the PML/ RARÏ« chimera fail to differentiate and exhibit an increased growth rate consequent to diminished apoptosis. PML/RARÏ« transforms myeloid precursors by recruiting the nuclear co-repressor (N-CoR)-histone deacetylase complex that is essential to retinoic acid-dependent myeloid differentiation. PML/ RARÏ« also recruits DNA methyltransferases in order to induce gene hypermethylation and silencing, which ultimately facilitates leukemogenesis.
- Reactivity
- Human
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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