BS1296

antibody from Bioworld Technology, Inc
Targeting: PML MYL, RNF71, TRIM19
Provider product page for BS1296
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS1296 - Provider product page
Provider
Bioworld Technology, Inc
Proper citation
Bioworld Technology Cat#BS1296, RRID:AB_1663695
Product name
PML (P39) polyclonal antibody
Antibody type
Polyclonal
Antigen
Synthetic peptide, corresponding to the N-terminal of Human PML.
Description
The PML protein is a zinc finger transcription factor expressed as three major transcription products due to alternative splicing. The gene encoding human PML maps to chromosome 15q22. The t(15;17) (q22;q11.2-q12) chromosomal trans-location of the retinoic acid receptor Ï« (RARÏ«) gene occurs in virtually all cases of acute promyelocytic leukemia and results in the expression of a PML/RARÏ« chimeric protein. Myeloid precursor cells expressing the PML/ RARÏ« chimera fail to differentiate and exhibit an increased growth rate consequent to diminished apoptosis. PML/RARÏ« transforms myeloid precursors by recruiting the nuclear co-repressor (N-CoR)-histone deacetylase complex that is essential to retinoic acid-dependent myeloid differentiation. PML/ RARÏ« also recruits DNA methyltransferases in order to induce gene hypermethylation and silencing, which ultimately facilitates leukemogenesis.
Reactivity
Human
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
PML protein structure - BS1296 shown in red.