PML

gene product
MYL, RNF71, TRIM19
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
More gene data

Featured antibodies

Antibodies

 

Filters

Antibodypedia Validation Initiative

Validation method

Application

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

  or   Clear
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Validated within AVI
Eligible for validation within AVI
475 antibodies from 39 providers.

Antibody properties

Applications

or Cancel
AntibodyRefsTypeAVIWBELICCIPIHCFC
Novus Biologicals
21 antibodies
Biorbyt
18 antibodies
Santa Cruz Biotechnology
2 antibodies
Abnova Corporation
14 antibodies
Abgent
3 antibodies
NSJ Bioreagents
3 antibodies
antibodies-online
127 antibodies
Invitrogen Antibodies
5 antibodies
Bethyl Laboratories
3 antibodies
Boster Biological Technology
4 antibodies
Aviva Systems Biology
5 antibodies
Acris Antibodies GmbH
17 antibodies
Enzo Life Sciences
1 antibody
OriGene
18 antibodies
LifeSpan BioSciences, Inc.
81 antibodies
Affinity Biosciences
1 antibody
GeneTex
3 antibodies
Bioworld Technology, Inc
2 antibodies
ProSci
2 antibodies
NovoPro Bioscience Inc.
4 antibodies
St John's Laboratory
3 antibodies
Atlas Antibodies
1 antibody
Sigma-Aldrich
6 antibodies
Abbiotec
1 antibody
Abbkine Scientific Co.Ltd.
1 antibody
Proteintech Group
1 antibody
MyBioSource
8 antibodies
Creative Biolabs
5 antibodies
Arigo
2 antibodies
Creative Diagnostics
5 antibodies
RabMAbs
2 antibodies
RayBiotech, Inc.
2 antibodies
United States Biological
69 antibodies
Spring Bioscience
4 antibodies
Abiocode, Inc.
2 antibodies
EMD Millipore
3 antibodies
Active Motif
1 antibody
Rockland Immunochemicals, Inc.
1 antibody