BCLAF1

This gene encodes a transcriptional repressor that interacts with several members of the BCL2 family of proteins. Overexpression of this protein induces apoptosis, which can be suppressed by co-expression of BCL2 proteins. The protein localizes to dot-like structures throughout the nucleus, and redistributes to a zone near the nuclear envelope in cells undergoing apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Description

BCL2-associated transcription factor 1

Protein family

Cancer-related genes, Mapped to UniProt SWISS-PROT, Plasma proteins, Predicted intracellular proteins, Protein evidence (Ezkurdia et al 2014), Protein evidence (Kim et al 2014)

Chromosome

6:q23.3 (136256863 - 136289851)

Ensembl ID

ENSG00000029363  (ver. 84.38)

Orthologs

Mouse Bclaf1: ENSMUSG00000037608

UniProt

Q9NYF8

neXtProt

NX_Q9NYF8

Human splice variants
Mouse splice variants