BCLAF1

This gene encodes a transcriptional repressor that interacts with several members of the BCL2 family of proteins. Overexpression of this protein induces apoptosis, which can be suppressed by co-expression of BCL2 proteins. The protein localizes to dot-like structures throughout the nucleus, and redistributes to a zone near the nuclear envelope in cells undergoing apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Description

BCL2 associated transcription factor 1

Tissue specificity

Tissue enhanced (bone marrow)

Subcell location

Nuclear speckles

Predicted location

Intracellular

Protein family

Cancer-related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

6:q23.3 (136256627 - 136289851)

Ensembl ID

ENSG00000029363  (ver. 103.38)

Orthologs

Mouse Bclaf1: ENSMUSG00000037608

UniProt

Q9NYF8

neXtProt

NX_Q9NYF8

Human splice variants
Mouse splice variants