Antibody data
- Antibody Data
- Antigen structure
- References [26]
- Comments [0]
- Validations
- Flow cytometry [1]
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- Product number
- NBP2-24902 - Provider product page
- Provider
- Novus Biologicals
- Product name
- Mouse Monoclonal TLR3 Antibody
- Antibody type
- Monoclonal
- Description
- Protein G purified.
- Reactivity
- Human, Mouse, Canine
- Host
- Mouse
- Conjugate
- Yellow dye
- Isotype
- IgG
- Vial size
- 0.1 ml
- Storage
- Store at 4C in the dark.
Submitted references Substance P represents a novel first-line defense mechanism in the nose.
Early IFN-γ production together with decreased expression of TLR3 and TLR9 characterizes EAE development conditional on the presence of myelin.
Toll-like receptor 3 expression and function in childhood idiopathic nephrotic syndrome.
Deprived TLR9 expression in apparently healthy nasal mucosa might trigger polyp-growth in chronic rhinosinusitis patients.
Toll-like receptor (TLR) expression of immune system cells from metastatic breast cancer patients with circulating tumor cells.
Characterization of the Toll-like receptor expression profile in human multiple myeloma cells.
Expression of Toll-like receptor-3 is enhanced in active inflammatory bowel disease and mediates the excessive release of lipocalin 2.
Toll-like receptor 3 and RIG-I-like receptor activation induces innate antiviral responses in mouse ovarian granulosa cells.
The role of UNC93B1 protein in surface localization of TLR3 receptor and in cell priming to nucleic acid agonists.
Epidermal growth factor receptor is essential for Toll-like receptor 3 signaling.
Short-interfering RNAs induce retinal degeneration via TLR3 and IRF3.
Engagement of TLR2 reverses the suppressor function of conjunctiva CD4+CD25+ regulatory T cells and promotes herpes simplex virus epitope-specific CD4+CD25- effector T cell responses.
Mechanism of endosomal TLR inhibition by antimalarial drugs and imidazoquinolines.
Extracts of the rat tapeworm, Hymenolepis diminuta, suppress macrophage activation in vitro and alleviate chemically induced colitis in mice.
Toll-like receptor 3 (TLR3) plays a major role in the formation of rabies virus Negri Bodies.
STAT3- and STAT5-dependent pathways competitively regulate the pan-differentiation of CD34pos cells into tumor-competent dendritic cells.
Antibodies specific for human or murine Toll-like receptors detect canine leukocytes by flow cytometry.
Inhibitors of TLR8 reduce TNF production from human rheumatoid synovial membrane cultures.
Inhibitors of TLR8 reduce TNF production from human rheumatoid synovial membrane cultures.
Biochemical and functional analyses of the human Toll-like receptor 3 ectodomain.
Intracellular signaling mechanisms regulating toll-like receptor-mediated activation of eosinophils.
Toll-like receptors in cellular subsets of human tonsil T cells: altered expression during recurrent tonsillitis.
High-avidity antitumor T-cell generation by toll receptor 8-primed, myeloid- derived dendritic cells is mediated by IL-12 production.
Inhibition of neutrophil apoptosis by TLR agonists in whole blood: involvement of the phosphoinositide 3-kinase/Akt and NF-kappaB signaling pathways, leading to increased levels of Mcl-1, A1, and phosphorylated Bad.
Inhibition of neutrophil apoptosis by TLR agonists in whole blood: involvement of the phosphoinositide 3-kinase/Akt and NF-kappaB signaling pathways, leading to increased levels of Mcl-1, A1, and phosphorylated Bad.
The cytoplasmic 'linker region' in Toll-like receptor 3 controls receptor localization and signaling.
Larsson O, Tengroth L, Xu Y, Uddman R, Kumlien Georén S, Cardell LO
The Journal of allergy and clinical immunology 2018 Jan;141(1):128-136.e3
The Journal of allergy and clinical immunology 2018 Jan;141(1):128-136.e3
Early IFN-γ production together with decreased expression of TLR3 and TLR9 characterizes EAE development conditional on the presence of myelin.
Evangelista MG, Castro SB, Alves CC, Dias AT, Souza VW, Reis LB, Silva LC, Castañon MC, Farias RE, Juliano MA, Ferreira AP
Autoimmunity 2016 Jun;49(4):258-67
Autoimmunity 2016 Jun;49(4):258-67
Toll-like receptor 3 expression and function in childhood idiopathic nephrotic syndrome.
Jamin A, Dehoux L, Dossier C, Fila M, Heming N, Monteiro RC, Deschênes G
Clinical and experimental immunology 2015 Dec;182(3):332-45
Clinical and experimental immunology 2015 Dec;182(3):332-45
Deprived TLR9 expression in apparently healthy nasal mucosa might trigger polyp-growth in chronic rhinosinusitis patients.
Tengroth L, Arebro J, Kumlien Georén S, Winqvist O, Cardell LO
PloS one 2014;9(8):e105618
PloS one 2014;9(8):e105618
Toll-like receptor (TLR) expression of immune system cells from metastatic breast cancer patients with circulating tumor cells.
Green TL, Santos MF, Ejaeidi AA, Craft BS, Lewis RE, Cruse JM
Experimental and molecular pathology 2014 Aug;97(1):44-8
Experimental and molecular pathology 2014 Aug;97(1):44-8
Characterization of the Toll-like receptor expression profile in human multiple myeloma cells.
Abdi J, Mutis T, Garssen J, Redegeld F
PloS one 2013;8(4):e60671
PloS one 2013;8(4):e60671
Expression of Toll-like receptor-3 is enhanced in active inflammatory bowel disease and mediates the excessive release of lipocalin 2.
Østvik AE, Granlund AV, Torp SH, Flatberg A, Beisvåg V, Waldum HL, Flo TH, Espevik T, Damås JK, Sandvik AK
Clinical and experimental immunology 2013 Sep;173(3):502-11
Clinical and experimental immunology 2013 Sep;173(3):502-11
Toll-like receptor 3 and RIG-I-like receptor activation induces innate antiviral responses in mouse ovarian granulosa cells.
Yan K, Zhu W, Yu L, Li N, Zhang X, Liu P, Chen Q, Chen Y, Han D
Molecular and cellular endocrinology 2013 Jun 15;372(1-2):73-85
Molecular and cellular endocrinology 2013 Jun 15;372(1-2):73-85
The role of UNC93B1 protein in surface localization of TLR3 receptor and in cell priming to nucleic acid agonists.
Pohar J, Pirher N, Benčina M, Manček-Keber M, Jerala R
The Journal of biological chemistry 2013 Jan 4;288(1):442-54
The Journal of biological chemistry 2013 Jan 4;288(1):442-54
Epidermal growth factor receptor is essential for Toll-like receptor 3 signaling.
Yamashita M, Chattopadhyay S, Fensterl V, Saikia P, Wetzel JL, Sen GC
Science signaling 2012 Jul 17;5(233):ra50
Science signaling 2012 Jul 17;5(233):ra50
Short-interfering RNAs induce retinal degeneration via TLR3 and IRF3.
Kleinman ME, Kaneko H, Cho WG, Dridi S, Fowler BJ, Blandford AD, Albuquerque RJ, Hirano Y, Terasaki H, Kondo M, Fujita T, Ambati BK, Tarallo V, Gelfand BD, Bogdanovich S, Baffi JZ, Ambati J
Molecular therapy : the journal of the American Society of Gene Therapy 2012 Jan;20(1):101-8
Molecular therapy : the journal of the American Society of Gene Therapy 2012 Jan;20(1):101-8
Engagement of TLR2 reverses the suppressor function of conjunctiva CD4+CD25+ regulatory T cells and promotes herpes simplex virus epitope-specific CD4+CD25- effector T cell responses.
Dasgupta G, Chentoufi AA, You S, Falatoonzadeh P, Urbano LA, Akhtarmalik A, Nguyen K, Ablabutyan L, Nesburn AB, BenMohamed L
Investigative ophthalmology & visual science 2011 May 17;52(6):3321-33
Investigative ophthalmology & visual science 2011 May 17;52(6):3321-33
Mechanism of endosomal TLR inhibition by antimalarial drugs and imidazoquinolines.
Kuznik A, Bencina M, Svajger U, Jeras M, Rozman B, Jerala R
Journal of immunology (Baltimore, Md. : 1950) 2011 Apr 15;186(8):4794-804
Journal of immunology (Baltimore, Md. : 1950) 2011 Apr 15;186(8):4794-804
Extracts of the rat tapeworm, Hymenolepis diminuta, suppress macrophage activation in vitro and alleviate chemically induced colitis in mice.
Johnston MJ, Wang A, Catarino ME, Ball L, Phan VC, MacDonald JA, McKay DM
Infection and immunity 2010 Mar;78(3):1364-75
Infection and immunity 2010 Mar;78(3):1364-75
Toll-like receptor 3 (TLR3) plays a major role in the formation of rabies virus Negri Bodies.
Ménager P, Roux P, Mégret F, Bourgeois JP, Le Sourd AM, Danckaert A, Lafage M, Préhaud C, Lafon M
PLoS pathogens 2009 Feb;5(2):e1000315
PLoS pathogens 2009 Feb;5(2):e1000315
STAT3- and STAT5-dependent pathways competitively regulate the pan-differentiation of CD34pos cells into tumor-competent dendritic cells.
Cohen PA, Koski GK, Czerniecki BJ, Bunting KD, Fu XY, Wang Z, Zhang WJ, Carter CS, Awad M, Distel CA, Nagem H, Paustian CC, Johnson TD, Tisdale JF, Shu S
Blood 2008 Sep 1;112(5):1832-43
Blood 2008 Sep 1;112(5):1832-43
Antibodies specific for human or murine Toll-like receptors detect canine leukocytes by flow cytometry.
Burgener IA, Jungi TW
Veterinary immunology and immunopathology 2008 Jul 15;124(1-2):184-91
Veterinary immunology and immunopathology 2008 Jul 15;124(1-2):184-91
Inhibitors of TLR8 reduce TNF production from human rheumatoid synovial membrane cultures.
Sacre SM, Lo A, Gregory B, Simmonds RE, Williams L, Feldmann M, Brennan FM, Foxwell BM
Journal of immunology (Baltimore, Md. : 1950) 2008 Dec 1;181(11):8002-9
Journal of immunology (Baltimore, Md. : 1950) 2008 Dec 1;181(11):8002-9
Inhibitors of TLR8 reduce TNF production from human rheumatoid synovial membrane cultures.
Sacre SM, Lo A, Gregory B, Simmonds RE, Williams L, Feldmann M, Brennan FM, Foxwell BM
Journal of immunology (Baltimore, Md. : 1950) 2008 Dec 1;181(11):8002-9
Journal of immunology (Baltimore, Md. : 1950) 2008 Dec 1;181(11):8002-9
Biochemical and functional analyses of the human Toll-like receptor 3 ectodomain.
Ranjith-Kumar CT, Miller W, Xiong J, Russell WK, Lamb R, Santos J, Duffy KE, Cleveland L, Park M, Bhardwaj K, Wu Z, Russell DH, Sarisky RT, Mbow ML, Kao CC
The Journal of biological chemistry 2007 Mar 9;282(10):7668-78
The Journal of biological chemistry 2007 Mar 9;282(10):7668-78
Intracellular signaling mechanisms regulating toll-like receptor-mediated activation of eosinophils.
Wong CK, Cheung PF, Ip WK, Lam CW
American journal of respiratory cell and molecular biology 2007 Jul;37(1):85-96
American journal of respiratory cell and molecular biology 2007 Jul;37(1):85-96
Toll-like receptors in cellular subsets of human tonsil T cells: altered expression during recurrent tonsillitis.
Mansson A, Adner M, Cardell LO
Respiratory research 2006 Feb 27;7:36
Respiratory research 2006 Feb 27;7:36
High-avidity antitumor T-cell generation by toll receptor 8-primed, myeloid- derived dendritic cells is mediated by IL-12 production.
Xu S, Koldovsky U, Xu M, Wang D, Fitzpatrick E, Son G, Koski G, Czerniecki BJ
Surgery 2006 Aug;140(2):170-8
Surgery 2006 Aug;140(2):170-8
Inhibition of neutrophil apoptosis by TLR agonists in whole blood: involvement of the phosphoinositide 3-kinase/Akt and NF-kappaB signaling pathways, leading to increased levels of Mcl-1, A1, and phosphorylated Bad.
François S, El Benna J, Dang PM, Pedruzzi E, Gougerot-Pocidalo MA, Elbim C
Journal of immunology (Baltimore, Md. : 1950) 2005 Mar 15;174(6):3633-42
Journal of immunology (Baltimore, Md. : 1950) 2005 Mar 15;174(6):3633-42
Inhibition of neutrophil apoptosis by TLR agonists in whole blood: involvement of the phosphoinositide 3-kinase/Akt and NF-kappaB signaling pathways, leading to increased levels of Mcl-1, A1, and phosphorylated Bad.
François S, El Benna J, Dang PM, Pedruzzi E, Gougerot-Pocidalo MA, Elbim C
Journal of immunology (Baltimore, Md. : 1950) 2005 Mar 15;174(6):3633-42
Journal of immunology (Baltimore, Md. : 1950) 2005 Mar 15;174(6):3633-42
The cytoplasmic 'linker region' in Toll-like receptor 3 controls receptor localization and signaling.
Funami K, Matsumoto M, Oshiumi H, Akazawa T, Yamamoto A, Seya T
International immunology 2004 Aug;16(8):1143-54
International immunology 2004 Aug;16(8):1143-54
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Flow Cytometry: TLR3 Antibody (40C1285.6) [PE] [NBP2-24902] - Intracellular analysis of TLR3 in human monocytes using 0.5 ug/10^6 cells of this antibody. Shaded histogram represents cells without antibody; green represents isotype control ; red represents anti-TLR3 antibody.