TLR3

gene product
CD283
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene. [provided by RefSeq, Jul 2008]
More gene data

Featured antibodies

Antibodies

 

Filters

Application

Antibodypedia Validation Initiative

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

  or   Clear
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Validated within AVI
Eligible for validation within AVI
1072 antibodies from 45 providers.

Antibody properties

General

Applications

or Cancel
AntibodyRefsTypeWBELICCIPIHCFC
Novus Biologicals
70 antibodies
Enzo Life Sciences
7 antibodies
antibodies-online
328 antibodies
Abnova Corporation
10 antibodies
GeneTex
9 antibodies
Invitrogen Antibodies
22 antibodies
Acris Antibodies GmbH
33 antibodies
LifeSpan BioSciences, Inc.
224 antibodies
OriGene
23 antibodies
NovoPro Bioscience Inc.
9 antibodies
R&D Systems
7 antibodies
Biorbyt
37 antibodies
Arigo
2 antibodies
Rockland Immunochemicals, Inc.
4 antibodies
BioLegend
7 antibodies
Boster Biological Technology
3 antibodies
ProSci
5 antibodies
Affinity Biosciences
2 antibodies
Abgent
9 antibodies
NSJ Bioreagents
6 antibodies
Aviva Systems Biology
8 antibodies
Bioworld Technology, Inc
1 antibody
FabGennix
3 antibodies
Creative Biolabs
77 antibodies