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ImmunohistochemistryAntibody data
- Antibody Data
- Antigen structure
- References [2]
- Comments [0]
- Validations
- Immunohistochemistry [1]
- Chromatin Immunoprecipitation [1]
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- Product number
- HPA024369 - Provider product page
- Provider
- Atlas Antibodies
- Proper citation
- Atlas Antibodies Cat#HPA024369, RRID:AB_1854413
- Product name
- Anti-NFATC2
- Antibody type
- Polyclonal
- Description
- Polyclonal Antibody against Human NFATC2, Gene description: nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2, Alternative Gene Names: NF-ATP, NFAT1, NFATp, Validated applications: ChIP, IHC, Uniprot ID: Q13469, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 µl
- Concentration
- 0.1 mg/ml
- Storage
- Store at +4°C for short term storage. Long time storage is recommended at -20°C.
- Handling
- The antibody solution should be gently mixed before use.
Submitted references Epithelial calcineurin controls microbiota-dependent intestinal tumor development
NFATc2 is an intrinsic regulator of melanoma dedifferentiation
Peuker K, Muff S, Wang J, Künzel S, Bosse E, Zeissig Y, Luzzi G, Basic M, Strigli A, Ulbricht A, Kaser A, Arlt A, Chavakis T, van den Brink G, Schafmayer C, Egberts J, Becker T, Bianchi M, Bleich A, Röcken C, Hampe J, Schreiber S, Baines J, Blumberg R, Zeissig S
Nature Medicine 2016;22(5):506-515
Nature Medicine 2016;22(5):506-515
NFATc2 is an intrinsic regulator of melanoma dedifferentiation
Perotti V, Baldassari P, Molla A, Vegetti C, Bersani I, Maurichi A, Santinami M, Anichini A, Mortarini R
Oncogene 2015;35(22):2862-2872
Oncogene 2015;35(22):2862-2872
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Supportive validation
- Submitted by
- Atlas Antibodies (provider)
- Enhanced method
- Orthogonal validation
- Main image
- Experimental details
- Immunohistochemistry analysis in human lymph node and cerebral cortex tissues using Anti-NFATC2 antibody. Corresponding NFATC2 RNA-seq data are presented for the same tissues.
- Sample type
- Human
- Protocol
- Protocol
Supportive validation
- Submitted by
- Atlas Antibodies (provider)
- Main image
- Experimental details
- ChIP-Exo-Seq composite graph for Anti-NFATC2 (HPA024369, Lot A114950) tested in K562 cells. Strand-specific reads (blue: forward, red: reverse) and IgG controls (black: forward, grey: reverse) are plotted against the distance from a composite set of reference binding sites. The antibody exhibits robust target enrichment compared to a non-specific IgG control and precisely reveals its structural organization around the binding site. Data generated by Prof. B. F. Pugh´s Lab at Cornell University.
