NFATC2

This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Apr 2012]

Description

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2

Protein family

Cancer-related genes, Mapped to UniProt SWISS-PROT, Predicted intracellular proteins, Protein evidence (Ezkurdia et al 2014), Protein evidence (Kim et al 2014), Transcription factors

Chromosome

20:q13.2 (51386957 - 51562831)

Ensembl ID

ENSG00000101096  (ver. 84.38)

Orthologs

Mouse Nfatc2: ENSMUSG00000027544

UniProt

Q13469

neXtProt

NX_Q13469

Human splice variants
Mouse splice variants