HEXIM2

This gene encodes a member of the HEXIM family of proteins. This protein is a component of the 7SK small nuclear ribonucleoprotein. This protein has been found to negatively regulate the kinase activity of the cyclin-dependent kinase P-TEFb, which phosphorylates multiple target proteins to promote transcriptional elongation. This gene is located approximately 7 kb downstream from related family member HEXIM1 on chromosome 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

Description

HEXIM P-TEFb complex subunit 2

Tissue specificity

Tissue enhanced (skeletal muscle, testis)

Subcell location

Nucleoplasm, Nuclear speckles

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

17 (45160700 - 45170040)

Ensembl ID

ENSG00000168517  (ver. 103.38)

Orthologs

Mouse Hexim2: ENSMUSG00000043372

UniProt

Q96MH2

neXtProt

NX_Q96MH2

Human splice variants
Mouse splice variants

Protein structure