HCFC2

This gene encodes one of two proteins which interact with VP16, a herpes simplex virus protein that initiates virus infection. Both the encoded protein and the original Herpes host cell factor interact with VP16 through a beta-propeller domain. The original Herpes host cell factor, however, is effective at initiating viral infection while the encoded protein is not. Transcripts of varying length due to alternative polyadenylation signals have been described. [provided by RefSeq, Jul 2008]

Description

Host cell factor C2

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Plasma membrane, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

12 (104064531 - 104106524)

Ensembl ID

ENSG00000111727  (ver. 103.38)

Orthologs

Mouse Hcfc2: ENSMUSG00000020246

UniProt

Q9Y5Z7

neXtProt

NX_Q9Y5Z7

Human splice variants
Mouse splice variants

Protein structure