BS60921

antibody from Bioworld Technology, Inc
Targeting: IL1R2 CD121b, IL1RB
Provider product page for BS60921

Antibody data

Product number
BS60921 - Provider product page
Provider
Bioworld Technology, Inc
Product name
IL1R2 polyclonal antibody
Antibody type
Polyclonal
Antigen
A synthetic peptide corresponding to residues in Human IL1R2.
Description
Decoy receptors are structurally incapable of activating signaling pathways, but act as anti-inflammatory agents by sequestering agonists for actual signaling complexes. The type II IL-1 receptor (IL-1RII) acts as a decoy receptor for the chemokine interleukin-1 (IL-1). Additionally, the soluble form of IL-1R accessory protein (IL-1R AcP) increases the affinity of binding of IL-1Ï« and IL-1ÉÇ to IL-1RII 100-fold, but does not increase the affinity for another antiinflammatory agent, IL-1R antagonist (IL-1Ra). The end result is a complex regulatory mechanism for IL-1 activated inflammation, whereby dexamethasone and other molecules inducing IL-1RII, function in an immunosupressive and anti-inflammatory manner.
Reactivity
Human, Mouse
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
IL1R2 protein structure - BS60921 shown in red.