TBX2

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product is the human homolog of mouse Tbx2, and shares strong sequence similarity with Drosophila omb protein. Expression studies indicate that this gene may have a potential role in tumorigenesis as an immortalizing agent. Transcript heterogeneity due to alternative polyadenylation has been noted for this gene. [provided by RefSeq, Jul 2008]

Description

T-box transcription factor 2

Tissue specificity

Tissue enhanced (lung)

Subcell location

Nucleoplasm, Cytosol

Predicted location

Intracellular

Protein family

Disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Transcription factors

Chromosome

17:q23.2 (61399843 - 61409466)

Ensembl ID

ENSG00000121068  (ver. 103.38)

Orthologs

Mouse Tbx2: ENSMUSG00000000093

UniProt

Q13207

neXtProt

NX_Q13207

Human splice variants
Mouse splice variants