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- References [18]
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- Product number
- 15170-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15170-1-AP, RRID:AB_2229978
- Product name
- CRAT antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated CRAT antibody (Cat. #15170-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Male obesity causes adipose mitochondrial dysfunction in F(1) mouse progeny via a let-7-DICER axis.
Palmitoyl-carnitine Regulates Lung Development by Promoting Pulmonary Mesenchyme Proliferation.
Sex Differences in Response to Diet Enriched With Glutathione Precursors in the Aging Heart.
A genetically encoded fluorescent biosensor for visualization of acetyl-CoA in live cells.
Androgen Receptors Promote Oxidative Phosphorylation and Resistance to Palmitate Lipotoxicity in ER-Mutant Breast Cancer.
Cyclic stretch Promotes osteogenesis of osteoblasts via ACh/α7nAChR pathway.
Artemether regulates liver glycogen and lipid utilization through mitochondrial pyruvate oxidation in db/db mice.
Mitochondrial fatty acid oxidation drives senescence.
Succinylation proteomic analysis identified differentially expressed succinylation sites affecting porcine muscle fiber type function.
CRAT links cholesterol metabolism to innate immune responses in the heart.
Stable isotope-labeled carnitine reveals its rapid transport into muscle cells and acetylation during contraction.
TGF-β1 attenuates mitochondrial bioenergetics in pulmonary arterial endothelial cells via the disruption of carnitine homeostasis.
Dissociation of Muscle Insulin Resistance from Alterations in Mitochondrial Substrate Preference.
Proximal Tubular Cell-Specific Ablation of Carnitine Acetyltransferase Causes Tubular Disease and Secondary Glomerulosclerosis.
Organelle-Derived Acetyl-CoA Promotes Prostate Cancer Cell Survival, Migration, and Metastasis via Activation of Calmodulin Kinase II.
Carnitine acetyltransferase (CRAT) expression in macrophages is dispensable for nutrient stress sensing and inflammation.
Disruption of endothelial cell mitochondrial bioenergetics in lambs with increased pulmonary blood flow.
Role of carnitine acetyl transferase in regulation of nitric oxide signaling in pulmonary arterial endothelial cells.
Huang C, Park JH, Altıntaş A, Stanic N, Kyle de Leon K, Isacson S, Kalogeropoulos P, Topel H, Madsen T, Zanner S, Ruppert PM, Valdebenito R, Havelund J, Larsen BDM, Chien YT, Huang WC, Budi YP, Jiang YF, Rocha AL, Lima-Junior NC, Szczepanowska K, Lackmann JW, Trifunovic A, Hejbøl EK, Detlefsen S, Jepsen IE, Kolstrup SH, Laguna-Barraza R, Martin-Gonzalez J, Khodosevich K, Færgeman NJ, Mori MA, Friedländer MR, Öst A, Barrès R, Kornfeld JW
Nature communications 2026 Feb 24;17(1)
Nature communications 2026 Feb 24;17(1)
Palmitoyl-carnitine Regulates Lung Development by Promoting Pulmonary Mesenchyme Proliferation.
Liu X, Lam SM, Zheng Y, Mo L, Li M, Sun T, Long X, Peng S, Zhang X, Mei M, Shui G, Bao S
Research (Washington, D.C.) 2025;8:0620
Research (Washington, D.C.) 2025;8:0620
Sex Differences in Response to Diet Enriched With Glutathione Precursors in the Aging Heart.
Angelini A, Garcia Marquez G, Malovannaya A, Fiorotto ML, Saltzman A, Jain A, Trial J, Taffet GE, Cieslik KA
The journals of gerontology. Series A, Biological sciences and medical sciences 2025 Jan 16;80(2)
The journals of gerontology. Series A, Biological sciences and medical sciences 2025 Jan 16;80(2)
A genetically encoded fluorescent biosensor for visualization of acetyl-CoA in live cells.
Smith JJ, Valentino TR, Ablicki AH, Banerjee R, Colligan AR, Eckert DM, Desjardins GA, Diehl KL
Cell chemical biology 2025 Feb 20;32(2):325-337.e10
Cell chemical biology 2025 Feb 20;32(2):325-337.e10
Androgen Receptors Promote Oxidative Phosphorylation and Resistance to Palmitate Lipotoxicity in ER-Mutant Breast Cancer.
Sessions DT, Boulton DP, Spoelstra NS, Caino MC, Yu M, Goodspeed A, Richer JK
Endocrinology 2025 Dec 5;167(1)
Endocrinology 2025 Dec 5;167(1)
Cyclic stretch Promotes osteogenesis of osteoblasts via ACh/α7nAChR pathway.
Guo H, Che X, Xiang R
Journal of biomechanics 2025 Apr;183:112616
Journal of biomechanics 2025 Apr;183:112616
Artemether regulates liver glycogen and lipid utilization through mitochondrial pyruvate oxidation in db/db mice.
Weng W, Shen L, Yu X, Yuan R, Shao M, Han P, Sun H
American journal of translational research 2024;16(1):27-38
American journal of translational research 2024;16(1):27-38
Mitochondrial fatty acid oxidation drives senescence.
Yamauchi S, Sugiura Y, Yamaguchi J, Zhou X, Takenaka S, Odawara T, Fukaya S, Fujisawa T, Naguro I, Uchiyama Y, Takahashi A, Ichijo H
Science advances 2024 Oct 25;10(43):eado5887
Science advances 2024 Oct 25;10(43):eado5887
Succinylation proteomic analysis identified differentially expressed succinylation sites affecting porcine muscle fiber type function.
Tan X, Liu K, He Y, Yan Z, Chen J, Zhao R, Sui X, Zhang J, Irwin DM, Zhang S, Li B
Food chemistry: X 2023 Dec 30;20:100962
Food chemistry: X 2023 Dec 30;20:100962
CRAT links cholesterol metabolism to innate immune responses in the heart.
Mao H, Angelini A, Li S, Wang G, Li L, Patterson C, Pi X, Xie L
Nature metabolism 2023 Aug;5(8):1382-1394
Nature metabolism 2023 Aug;5(8):1382-1394
Stable isotope-labeled carnitine reveals its rapid transport into muscle cells and acetylation during contraction.
Furuichi Y, Goto-Inoue N, Uchida S, Masuda S, Manabe Y, Fujii NL
Heliyon 2023 Apr;9(4):e15281
Heliyon 2023 Apr;9(4):e15281
TGF-β1 attenuates mitochondrial bioenergetics in pulmonary arterial endothelial cells via the disruption of carnitine homeostasis.
Sun X, Lu Q, Yegambaram M, Kumar S, Qu N, Srivastava A, Wang T, Fineman JR, Black SM
Redox biology 2020 Sep;36:101593
Redox biology 2020 Sep;36:101593
Dissociation of Muscle Insulin Resistance from Alterations in Mitochondrial Substrate Preference.
Song JD, Alves TC, Befroy DE, Perry RJ, Mason GF, Zhang XM, Munk A, Zhang Y, Zhang D, Cline GW, Rothman DL, Petersen KF, Shulman GI
Cell metabolism 2020 Nov 3;32(5):726-735.e5
Cell metabolism 2020 Nov 3;32(5):726-735.e5
Proximal Tubular Cell-Specific Ablation of Carnitine Acetyltransferase Causes Tubular Disease and Secondary Glomerulosclerosis.
Kruger C, Nguyen TT, Breaux C, Guillory A, Mangelli M, Fridianto KT, Kovalik JP, Burk DH, Noland RC, Mynatt R, Stadler K
Diabetes 2019 Apr;68(4):819-831
Diabetes 2019 Apr;68(4):819-831
Organelle-Derived Acetyl-CoA Promotes Prostate Cancer Cell Survival, Migration, and Metastasis via Activation of Calmodulin Kinase II.
Yu G, Cheng CJ, Lin SC, Lee YC, Frigo DE, Yu-Lee LY, Gallick GE, Titus MA, Nutt LK, Lin SH
Cancer research 2018 May 15;78(10):2490-2502
Cancer research 2018 May 15;78(10):2490-2502
Carnitine acetyltransferase (CRAT) expression in macrophages is dispensable for nutrient stress sensing and inflammation.
Goldberg EL, Dixit VD
Molecular metabolism 2017 Feb;6(2):219-225
Molecular metabolism 2017 Feb;6(2):219-225
Disruption of endothelial cell mitochondrial bioenergetics in lambs with increased pulmonary blood flow.
Sun X, Sharma S, Fratz S, Kumar S, Rafikov R, Aggarwal S, Rafikova O, Lu Q, Burns T, Dasarathy S, Wright J, Schreiber C, Radman M, Fineman JR, Black SM
Antioxidants & redox signaling 2013 May 10;18(14):1739-52
Antioxidants & redox signaling 2013 May 10;18(14):1739-52
Role of carnitine acetyl transferase in regulation of nitric oxide signaling in pulmonary arterial endothelial cells.
Sharma S, Sun X, Agarwal S, Rafikov R, Dasarathy S, Kumar S, Black SM
International journal of molecular sciences 2012 Dec 21;14(1):255-72
International journal of molecular sciences 2012 Dec 21;14(1):255-72
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The CRAT antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human CRAT. This antibody recognizes human,mouse,rat antigen. The CRAT antibody has been validated for the following applications: ELISA, WB analysis.
