HOXB6

This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development, including that of lung and skin, and has been localized to both the nucleus and cytoplasm. Altered expression of this gene or a change in the subcellular localization of its protein is associated with some cases of acute myeloid leukemia and colorectal cancer. [provided by RefSeq, Jul 2008]

Description

Homeobox B6

Tissue specificity

Tissue enhanced (epididymis, kidney)

Subcell location

Nucleoplasm, Golgi apparatus

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Transcription factors

Chromosome

17 (48595751 - 48604992)

Ensembl ID

ENSG00000108511  (ver. 103.38)

Orthologs

Mouse Hoxb6: ENSMUSG00000000690

UniProt

P17509

neXtProt

NX_P17509

Human splice variants
Mouse splice variants

Protein structure