18236-1-AP

antibody from Proteintech Group

Targeting: TRPC6 FSGS2, TRP6

Provider product page for 18236-1-AP

Western blot

ELISA

Immunoprecipitation

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [24]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [1]

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Product number: 18236-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#18236-1-AP, RRID:AB_10859822
Product name: TRPC6 antibody
Antibody type: Polyclonal
Description: KD/KO validated TRPC6 antibody (Cat. #18236-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: FC, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

TRPC6 protein structure - 18236-1-AP shown in red.

Submitted references Xiaozheng Anshen Formula alleviates podocyte injury in diabetic kidney disease by restoring autophagy flux via inhibiting TRPC6-mediated calcium signaling.

Yan Z, Bai J, Liang Y, Du Y, Wu R, Chen Z, Wang Y, Zhou J
Journal of ethnopharmacology 2026 Jun 28;365:121580

Congenital Hypothyroidism Dysregulates TRPC6 to Mediate Abnormal Dendritic Spine Growth of Hippocampal Neurons.

Li T, Shen F, Li L, Chen P, Zhu Z, Zheng Y, Li H, Suo G, Wang Y, Shi J, Wu Y
CNS neuroscience & therapeutics 2025 Sep;31(9):e70618

Epigenetic reprogramming of HDAC2 in CA1 excitatory neurons determines Pb-induced non-spatial memory deficits.

Wang M, Huang C, Ai S, Xia Y, Li C, Zhi Y, Wang K, Nie M, Gu X, Xu Y, Zhang H, Wang HL
Journal of hazardous materials 2025 Sep 5;495:138818

Luteolin prevents axitinib-induced kidney damage in mice.

Niu N, Li X, Tang D, Jin TQ, Ji SW, Yu CL, Li Y
Chemico-biological interactions 2025 Sep 5;418:111628

The axis of miR-30a/AIF-1/TRPC6/calcineurin A/NFAT2 regulated the death modalities and inflammation of renal tubular epithelial cells in diabetic kidney disease via exosome.

Hao J, Wang S, Guo X, Guo X, Hao L
Life sciences 2025 Sep 15;377:123760

Staple oligomers induce a stable RNA G-quadruplex structure for protein translation inhibition in therapeutics.

Katsuda Y, Kamura T, Kida T, Ohno R, Shiroto S, Hasegawa Y, Utsumi K, Sakamoto Y, Nakamura S, Nakamura T, Tsujita K, Kitamura Y, Kamiya Y, Asanuma H, Ihara T, Hagihara M, Sato SI
Nature biomedical engineering 2025 Oct 15;

Impact of C-Terminal PKC Phosphorylation on TRPC6 Current Kinetics.

Keck M, Pöll S, Schmelzer H, Kressmann T, Hermann C, Mederos Y Schnitzler M, Storch U
International journal of molecular sciences 2025 Nov 27;26(23)

Exploration of Conserved Human Adipose Subpopulations Using Targeted Single-Nuclei RNA Sequencing Data Sets.

Potts CM, Yang X, Lynes MD, Malka K, Liaw L
Journal of the American Heart Association 2025 Mar 18;14(6):e038465

Clonidine mitigates noise-induced hearing loss by regulating TRPC6-mediated calcium influx in cochlear hair cells.

Zhai W, Kuang X, Wu J, Li L, Li B, Geng R, Zheng T, Zheng Q
Hearing research 2025 Jun;462:109284

Benzothiazole amide analogues as antagonists of TRPC 6 channels: A therapeutic approach for kidney fibrosis.

Ren C, Xu Q, Luo Q, Qiao X, Ding T, Wang W, Zeng X, Chen C, Xiao Y, Hong X
European journal of medicinal chemistry 2025 Jul 5;291:117628

Tinglu Yixin granule inhibited fibroblast-myofibroblast transdifferentiation to ameliorate myocardial fibrosis in diabetic mice.

Zhang M, Sun X, Zhao F, Chen Z, Liu M, Wang P, Lu P, Wang X
Journal of ethnopharmacology 2025 Jan 30;337(Pt 3):118980

TRPC6-Calpain-1 Axis Promotes Tubulointerstitial Inflammation by Inhibiting Mitophagy in Diabetic Kidney Disease.

Liu CC, Ji JL, Wang Z, Zhang XJ, Ding L, Zhang Y, Zhou Y, Zhang DJ, Tang ZL, Cao JY, Zhang AQ, Liu BC, Li ZL, Ma RX
Kidney international reports 2024 Nov;9(11):3301-3317

High cadmium exposure impairs adult hippocampal neurogenesis via disruption of store-operated calcium entry.

Li G, Sun C, Zhu L, Zeng Y, Li J, Mei Y
Ecotoxicology and environmental safety 2024 Nov 1;286:117162

Larixyl acetate, a TRPC6 inhibitor, attenuates pressure overload‑induced heart failure in mice.

Jia M, Liu W, Zhang K, Wang Z, Li R, Pan J, Yang J, Wang D
Molecular medicine reports 2024 Mar;29(3)

The calcium channel TRPC6 promotes chemotherapy-induced persistence by regulating integrin α6 mRNA splicing.

Mukhopadhyay D, Goel HL, Xiong C, Goel S, Kumar A, Li R, Zhu LJ, Clark JL, Brehm MA, Mercurio AM
Cell reports 2023 Nov 28;42(11):113347

Deciphering the pharmacological mechanisms of Rostellularia procumbens (L) Nees. Extract alleviates adriamycin-induced nephropathy in vivo and in vitro.

Ai Z, Wang M, Zhou Y, Yuan D, Jian Q, Wu S, Liu B, Yang Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 May;113:154736

Dexmedetomidine Alleviates Neuropathic Pain via the TRPC6-p38 MAPK Pathway in the Dorsal Root Ganglia of Rats.

Xu S, Yi Y, Wang Y, Wang P, Zhao Y, Feng W
Journal of pain research 2022;15:2437-2448

Sildenafil protects against pulmonary hypertension induced by hypoxia in neonatal rats via activation of PPARγ‑mediated downregulation of TRPC.

Huang W, Liu N, Tong X, Du Y
International journal of molecular medicine 2022 Feb;49(2)

TRPC6 interacted with K(Ca)1.1 channels to regulate the proliferation and apoptosis of glioma cells.

Yin H, Cheng H, Li P, Yang Z
Archives of biochemistry and biophysics 2022 Aug 15;725:109268

Amelioration of circadian disruption and calcium-handling protein defects by choline alleviates cardiac remodeling in abdominal aorta coarctation rats.

He X, Yang S, Deng J, Wu Q, Zang WJ
Laboratory investigation; a journal of technical methods and pathology 2021 Jul;101(7):878-896

Regenerative Metaplastic Clones in COPD Lung Drive Inflammation and Fibrosis.

Rao W, Wang S, Duleba M, Niroula S, Goller K, Xie J, Mahalingam R, Neupane R, Liew AA, Vincent M, Okuda K, O'Neal WK, Boucher RC, Dickey BF, Wechsler ME, Ibrahim O, Engelhardt JF, Mertens TCJ, Wang W, Jyothula SSK, Crum CP, Karmouty-Quintana H, Parekh KR, Metersky ML, McKeon FD, Xian W
Cell 2020 May 14;181(4):848-864.e18

Nongenetic optical modulation of neural stem cell proliferation and neuronal/glial differentiation.

Wang M, Xu Z, Liu Q, Sun W, Jiang B, Yang K, Li J, Gong Y, Liu Q, Liu D, Li X
Biomaterials 2019 Dec;225:119539

Catalpol alleviates adriamycin-induced nephropathy by activating the SIRT1 signalling pathway in vivo and in vitro.

Zhang J, Bi R, Meng Q, Wang C, Huo X, Liu Z, Wang C, Sun P, Sun H, Ma X, Wu J, Liu K
British journal of pharmacology 2019 Dec;176(23):4558-4573

TRPC6 channel translocation into phagosomal membrane augments phagosomal function.

Riazanski V, Gabdoulkhakova AG, Boynton LS, Eguchi RR, Deriy LV, Hogarth DK, Loaëc N, Oumata N, Galons H, Brown ME, Shevchenko P, Gallan AJ, Yoo SG, Naren AP, Villereal ML, Beacham DW, Bindokas VP, Birnbaumer L, Meijer L, Nelson DJ
Proceedings of the National Academy of Sciences of the United States of America 2015 Nov 24;112(47):E6486-95

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: mouse lung tissue were subjected to SDS PAGE followed by western blot with 18236-1-AP(TRPC6 antibody) at dilution of 1:500
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The TRPC6 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human TRPC6. This antibody recognizes human, mouse antigen. The TRPC6 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 18236-1-AP.pdf

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