Antibody data
- Antibody Data
- Antigen structure
- References [138]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
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Validation data
Reference
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- Product number
- 18165-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#18165-1-AP, RRID:AB_2144858
- Product name
- MMP13 antibody
- Antibody type
- Polyclonal
- Description
- MMP13 antibody (Cat. #18165-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Mettl3 inhibits the apoptosis and autophagy of chondrocytes in inflammation through mediating Bcl2 stability via Ythdf1-mediated m6A modification.
Fermentation supernatant of Staphylococcus aureus drives catabolism in chondrocytes via NF-κB signaling mediated increase of cholesterol metabolism.
Reducing Inflammation and Vascular Invasion in Intervertebral Disc Degeneration via Cystathionine-γ-Lyase Inhibitory Effect on E-Selectin.
Osteocyte Apoptosis Contributes to Cold Exposure-induced Bone Loss.
Exosomes Isolated From Bone Marrow Mesenchymal Stem Cells Exert a Protective Effect on Osteoarthritis via lncRNA LYRM4-AS1-GRPR-miR-6515-5p.
Leptin Induced TLR4 Expression via the JAK2-STAT3 Pathway in Obesity-Related Osteoarthritis.
MCC950, the NLRP3 Inhibitor, Protects against Cartilage Degradation in a Mouse Model of Osteoarthritis.
Bardoxolone-Methyl Prevents Oxidative Stress-Mediated Apoptosis and Extracellular Matrix Degradation in vitro and Alleviates Osteoarthritis in vivo.
Aberrant Fluid Shear Stress Contributes to Articular Cartilage Pathogenesis via Epigenetic Regulation of ZBTB20 by H3K4me3.
Exosome-Encapsulated microRNA-127-3p Released from Bone Marrow-Derived Mesenchymal Stem Cells Alleviates Osteoarthritis Through Regulating CDH11-Mediated Wnt/β-Catenin Pathway.
Isovitexin Depresses Osteoarthritis Progression via the Nrf2/NF-κB Pathway: An in vitro Study.
Therapeutic Effects of Naringin in Rheumatoid Arthritis: Network Pharmacology and Experimental Validation.
Exhausting circ_0136474 and Restoring miR-766-3p Attenuate Chondrocyte Oxidative Injury in IL-1β-Induced Osteoarthritis Progression Through Regulating DNMT3A.
MicroRNA-497 Reduction and Increase of Its Family Member MicroRNA-424 Lead to Dysregulation of Multiple Inflammation Related Genes in Synovial Fibroblasts With Rheumatoid Arthritis.
Injectable exosome-functionalized extracellular matrix hydrogel for metabolism balance and pyroptosis regulation in intervertebral disc degeneration.
Integrative analysis of genome-wide DNA methylation and single-nucleotide polymorphism identified ACSM5 as a suppressor of lumbar ligamentum flavum hypertrophy.
Asporin regulated by miR-26b-5p mediates chondrocyte senescence and exacerbates osteoarthritis progression via TGF-β1/Smad2 pathway.
18β-Glycyrrhetinic acid inhibits IL-1β-induced inflammatory response in mouse chondrocytes and prevents osteoarthritic progression by activating Nrf2.
Therapeutic effect of neohesperidin on TNF-α-stimulated human rheumatoid arthritis fibroblast-like synoviocytes.
Frugoside delays osteoarthritis progression via inhibiting miR-155-modulated synovial macrophage M1 polarization.
SP600125 Restored TNF-α-Induced Impaired Chondrogenesis in Bone Mesenchymal Stem Cells and Its Antiosteoarthritis Effect in Mice.
Compressive force regulates cementoblast migration via downregulation of autophagy.
Effects of mechanical stress and deficiency of dihydrotestosterone or 17β-estradiol on Temporomandibular Joint Osteoarthritis in mice.
Regulation of osteoarthritis development by ADAM17/Tace in articular cartilage.
MFG-E8 regulated by miR-99b-5p protects against osteoarthritis by targeting chondrocyte senescence and macrophage reprogramming via the NF-κB pathway.
Decreased miR-214-3p activates NF-κB pathway and aggravates osteoarthritis progression.
Senolytic agent Quercetin ameliorates intervertebral disc degeneration via the Nrf2/NF-κB axis.
d-Mannose suppresses osteoarthritis development in vivo and delays IL-1β-induced degeneration in vitro by enhancing autophagy activated via the AMPK pathway.
Cardamonin protects nucleus pulposus cells against IL-1β-induced inflammation and catabolism via Nrf2/NF-κB axis.
Inhibition of HDAC6 by Tubastatin A reduces chondrocyte oxidative stress in chondrocytes and ameliorates mouse osteoarthritis by activating autophagy.
BMP5 silencing inhibits chondrocyte senescence and apoptosis as well as osteoarthritis progression in mice.
Phgdh serves a protective role in Il‑1β induced chondrocyte inflammation and oxidative‑stress damage.
AMD3465 (hexahydrobromide) rescues the MG63 osteoblasts against the apoptosis induced by high glucose.
TGF-β/Alk5 signaling prevents osteoarthritis initiation via regulating the senescence of articular cartilage stem cells.
α-Cyperone (CYP) down-regulates NF-κB and MAPKs signaling, attenuating inflammation and extracellular matrix degradation in chondrocytes, to ameliorate osteoarthritis in mice.
Activation of transient receptor potential vanilloid 4 protects articular cartilage against inflammatory responses via CaMKK/AMPK/NF-κB signaling pathway.
Metabolic reprogramming in chondrocytes to promote mitochondrial respiration reduces downstream features of osteoarthritis.
LncRNA H19-Derived miR-675-5p Accelerates the Invasion of Extravillous Trophoblast Cells by Inhibiting GATA2 and Subsequently Activating Matrix Metalloproteinases.
The Role of Panx3 in Age-Associated and Injury-Induced Intervertebral Disc Degeneration.
Endoplasmic reticulum stress pathway mediates T-2 toxin-induced chondrocyte apoptosis.
Acetabular development and fate of inverted limbus in rabbits: Experimental observation from an animal model.
Glucagon-like peptide-1 receptor activation maintains extracellular matrix integrity by inhibiting the activity of mitogen-activated protein kinases and activator protein-1.
Silencing BLNK protects against interleukin-1β-induced chondrocyte injury through the NF-κB signaling pathway.
Role of the hippo signaling pathway in the extracellular matrix degradation of chondrocytes induced by fluoride exposure.
TGF-β1-stimulation of NFATC2 and ATF3 proteins and their interaction for matrix metalloproteinase 13 expression in human breast cancer cells.
Involvement of Transient Receptor Potential Vanilloid Channel 2 in the Induction of Lubricin and Suppression of Ectopic Endochondral Ossification in Mouse Articular Cartilage.
Scleraxis expressing scleral cells respond to inflammatory stimulation.
Suramin attenuates intervertebral disc degeneration by inhibiting NF-κB signalling pathway.
METTL3 involves the progression of osteoarthritis probably by affecting ECM degradation and regulating the inflammatory response.
Oroxylin A attenuates IL-1β-induced inflammatory reaction via inhibiting the activation of the ERK and PI3K/AKT signaling pathways in osteoarthritis chondrocytes.
Effects of HDAC4 on IL-1β-induced matrix metalloproteinase expression regulated partially through the WNT3A/β-catenin pathway.
ZIP8 mediates the extracellular matrix degradation of nucleus pulposus cells via NF-κB signaling pathway.
OPN Deficiency Increases the Severity of Osteoarthritis Associated with Aberrant Chondrocyte Senescence and Apoptosis and Upregulates the Expression of Osteoarthritis-Associated Genes.
Punicalagin Inhibits Tert-Butyl Hydroperoxide-Induced Apoptosis and Extracellular Matrix Degradation in Chondrocytes by Activating Autophagy and Ameliorates Murine Osteoarthritis.
LncRNA TRPC7-AS1 regulates nucleus pulposus cellular senescence and ECM synthesis via competing with HPN for miR-4769-5p binding.
A chondroprotective effect of moracin on IL-1β-induced primary rat chondrocytes and an osteoarthritis rat model through Nrf2/HO-1 and NF-κB axes.
TLR4 contributes to the damage of cartilage and subchondral bone in discectomy-induced TMJOA mice.
S-allyl cysteine reduces osteoarthritis pathology in the tert-butyl hydroperoxide-treated chondrocytes and the destabilization of the medial meniscus model mice via the Nrf2 signaling pathway.
IL-37 inhibits M1-like macrophage activation to ameliorate temporomandibular joint inflammation through the NLRP3 pathway.
Heparan sulfate deficiency leads to hypertrophic chondrocytes by increasing bone morphogenetic protein signaling.
miR-873-3p targets HDAC4 to stimulate matrix metalloproteinase-13 expression upon parathyroid hormone exposure in rat osteoblasts.
Reducing macrophage numbers alleviates temporomandibular joint ankylosis.
Oxymatrine suppresses IL-1β-induced degradation of the nucleus pulposus cell and extracellular matrix through the TLR4/NF-κB signaling pathway.
Paclitaxel-induced peripheral neuropathy is caused by epidermal ROS and mitochondrial damage through conserved MMP-13 activation.
Long non-coding RNA SNHG15 is a competing endogenous RNA of miR-141-3p that prevents osteoarthritis progression by upregulating BCL2L13 expression.
Casticin Attenuates Osteoarthritis-Related Cartilage Degeneration by Inhibiting the ROS-Mediated NF-κB Signaling Pathway in vitro and in vivo.
Curcumol may reverse early and advanced liver fibrogenesis through downregulating the uPA/uPAR pathway.
MicroRNA-675-3p regulates IL-1β-stimulated human chondrocyte apoptosis and cartilage degradation by targeting GNG5.
The protective effect of myricitrin in osteoarthritis: An in vitro and in vivo study.
MiR-455-3p reduces apoptosis and alleviates degeneration of chondrocyte through regulating PI3K/AKT pathway.
Hypoxic mast cells accelerate the proliferation, collagen accumulation and phenotypic alteration of human lung fibroblasts.
Targeting exosome-associated human antigen R attenuates fibrosis and inflammation in diabetic heart.
MicroRNA-377-3p alleviates IL-1β-caused chondrocyte apoptosis and cartilage degradation in osteoarthritis in part by downregulating ITGA6.
Protective effect of resveratrol on obesity-related osteoarthritis via alleviating JAK2/STAT3 signaling pathway is independent of SOCS3.
Inhibition of PI3K/Akt/NF-κB signaling by Aloin for ameliorating the progression of osteoarthritis: In vitro and in vivo studies.
Exogenous hydrogen sulfide inhibits apoptosis by regulating endoplasmic reticulum stress-autophagy axis and improves myocardial reconstruction after acute myocardial infarction.
Stachydrine ameliorates the progression of intervertebral disc degeneration via the PI3K/Akt/NF-κB signaling pathway: in vitro and in vivo studies.
Glycitin Suppresses Cartilage Destruction of Osteoarthritis in Mice.
Crenigacestat, a selective NOTCH1 inhibitor, reduces intrahepatic cholangiocarcinoma progression by blocking VEGFA/DLL4/MMP13 axis.
Macromechanics and polycaprolactone fiber organization drive macrophage polarization and regulate inflammatory activation of tendon in vitro and in vivo.
Vitamin D3 protects articular cartilage by inhibiting the Wnt/β-catenin signaling pathway.
IκB kinase α: an independent prognostic factor that promotes the migration and invasion of oral squamous cell carcinoma.
Keratocytes promote corneal neovascularization through VEGFr3 induced by PPARα-inhibition.
FTO promotes cell proliferation and migration in esophageal squamous cell carcinoma through up-regulation of MMP13.
25-HC promotes hepatocellular carcinoma metastasis through up-regulation of TLR4 dependent FABP4.
A Compound of Chinese Herbs Protects against Alcoholic Liver Fibrosis in Rats via the TGF-β1/Smad Signaling Pathway.
KLF2 Protects against Osteoarthritis by Repressing Oxidative Response through Activation of Nrf2/ARE Signaling In Vitro and In Vivo.
Nobiletin Inhibits IL-1β-Induced Inflammation in Chondrocytes via Suppression of NF-κB Signaling and Attenuates Osteoarthritis in Mice.
Targeting the IL-1β/IL-1Ra pathways for the aggregation of human islet amyloid polypeptide in an ex vivo organ culture system of the intervertebral disc.
Effects of simvastatin on matrix metalloproteinase regulation in IL-1β-induced SW1353 cells.
Alleviation of murine osteoarthritis by deletion of the focal adhesion mechanosensitive adapter, Hic-5.
Development of a Mouse Model of Knee Osteoarthritis Based on Obesity and Bipedal Walking.
ZnO nanoparticles inhibit the activity of Porphyromonas gingivalis and Actinomyces naeslundii and promote the mineralization of the cementum.
25-HC decreases the sensitivity of human gastric cancer cells to 5-fluorouracil and promotes cells invasion via the TLR2/NF-κB signaling pathway.
Cortistatin binds to TNF-α receptors and protects against osteoarthritis.
miR-100-5p-abundant exosomes derived from infrapatellar fat pad MSCs protect articular cartilage and ameliorate gait abnormalities via inhibition of mTOR in osteoarthritis.
miR-93-5p attenuates IL-1β-induced chondrocyte apoptosis and cartilage degradation in osteoarthritis partially by targeting TCF4.
Adamts17 is involved in skeletogenesis through modulation of BMP-Smad1/5/8 pathway.
Quercetin alleviates rat osteoarthritis by inhibiting inflammation and apoptosis of chondrocytes, modulating synovial macrophages polarization to M2 macrophages.
Reduced PDGF-AA in subchondral bone leads to articular cartilage degeneration after strenuous running.
Inhibition of Ihh Reverses Temporomandibular Joint Osteoarthritis via a PTH1R Signaling Dependent Mechanism.
Effects of IL-1β on MMP-9 Expression in Cementoblast-Derived Cell Line and MMP-Mediated Degradation of Type I Collagen.
SIRT3 Activation by Dihydromyricetin Suppresses Chondrocytes Degeneration via Maintaining Mitochondrial Homeostasis.
mTOR-mediated inactivation of 4E-BP1, an inhibitor of translation, precedes cartilage degeneration in rat osteoarthritic knees.
Differential effects of high-physiological oestrogen on the degeneration of mandibular condylar cartilage and subchondral bone.
Loss of Fgfr1 in chondrocytes inhibits osteoarthritis by promoting autophagic activity in temporomandibular joint.
ETV4 transcription factor and MMP13 metalloprotease are interplaying actors of breast tumorigenesis.
Postnatal deletion of Alk5 gene in meniscal cartilage accelerates age-dependent meniscal degeneration in mice.
Toxoplasma gondii GRA15II effector-induced M1 cells ameliorate liver fibrosis in mice infected with Schistosomiasis japonica.
Emodin ameliorates cartilage degradation in osteoarthritis by inhibiting NF-κB and Wnt/β-catenin signaling in-vitro and in-vivo.
Tumor-derived exosomes educate dendritic cells to promote tumor metastasis via HSP72/HSP105-TLR2/TLR4 pathway.
Chondroprotective Effects and Multitarget Mechanisms of Fu Yuan Capsule in a Rat Osteoarthritis Model.
Upregulation of FBXW7 Suppresses Renal Cancer Metastasis and Epithelial Mesenchymal Transition.
Cartilage-specific deletion of Alk5 gene results in a progressive osteoarthritis-like phenotype in mice.
Icariin inhibits MMP‑1, MMP‑3 and MMP‑13 expression through MAPK pathways in IL‑1β‑stimulated SW1353 chondrosarcoma cells.
Simvastatin Inhibits IL-1β-Induced Apoptosis and Extracellular Matrix Degradation by Suppressing the NF-kB and MAPK Pathways in Nucleus Pulposus Cells.
Potential Involvement of the IL-6/JAK/STAT3 Pathway in the Pathogenesis of Intervertebral Disc Degeneration.
AMPK deficiency in chondrocytes accelerated the progression of instability-induced and ageing-associated osteoarthritis in adult mice.
Chlorogenic acid prevents inflammatory responses in IL‑1β‑stimulated human SW‑1353 chondrocytes, a model for osteoarthritis.
Conditional knockdown of hyaluronidase 2 in articular cartilage stimulates osteoarthritic progression in a mice model.
Fibroblast Growth Factor Receptor 3 Inhibits Osteoarthritis Progression in the Knee Joints of Adult Mice.
Iron overload in a murine model of hereditary hemochromatosis is associated with accelerated progression of osteoarthritis under mechanical stress.
Conditional knockout of tissue factor pathway inhibitor 2 in vascular endothelial cells accelerates atherosclerotic plaque development in mice.
Exogenous fibroblast growth factor 9 attenuates cartilage degradation and aggravates osteophyte formation in post-traumatic osteoarthritis.
Conditional Deletion of Fgfr3 in Chondrocytes leads to Osteoarthritis-like Defects in Temporomandibular Joint of Adult Mice.
Levofloxacin increases apoptosis of rat annulus fibrosus cells via the mechanism of upregulating MMP-2 and MMP-13.
Deletion of Dual Specificity Phosphatase 1 Does Not Predispose Mice to Increased Spontaneous Osteoarthritis.
17β-estradiol protects against apoptosis induced by interleukin-1β in rat nucleus pulposus cells by down-regulating MMP-3 and MMP-13.
Deletion of Panx3 Prevents the Development of Surgically Induced Osteoarthritis.
Potent effects of dioscin against liver fibrosis.
Keratocytes create stromal spaces to promote corneal neovascularization via MMP13 expression.
Protective effects of biochanin A on articular cartilage: in vitro and in vivo studies.
Chondroprotective effects and multi-target mechanisms of Icariin in IL-1 beta-induced human SW 1353 chondrosarcoma cells and a rat osteoarthritis model.
Loss of Vhl in cartilage accelerated the progression of age-associated and surgically induced murine osteoarthritis.
Suppression of hyaluronan synthesis alleviates inflammatory responses in murine arthritis and in human rheumatoid synovial fibroblasts.
Celastrol, an inhibitor of heat shock protein 90β potently suppresses the expression of matrix metalloproteinases, inducible nitric oxide synthase and cyclooxygenase-2 in primary human osteoarthritic chondrocytes.
Anti-arthritic effects of crocin in interleukin-1β-treated articular chondrocytes and cartilage in a rabbit osteoarthritic model.
Genetic inhibition of fibroblast growth factor receptor 1 in knee cartilage attenuates the degeneration of articular cartilage in adult mice.
He Y, Wang W, Xu X, Yang B, Yu X, Wu Y, Wang J
Bone 2022 Jan;154:116182
Bone 2022 Jan;154:116182
Fermentation supernatant of Staphylococcus aureus drives catabolism in chondrocytes via NF-κB signaling mediated increase of cholesterol metabolism.
Wang Q, Huang J, Li S, Zhang Y, Sun R, Ren J, Shi S, Cui L
Experimental cell research 2022 Jan 1;410(1):112952
Experimental cell research 2022 Jan 1;410(1):112952
Reducing Inflammation and Vascular Invasion in Intervertebral Disc Degeneration via Cystathionine-γ-Lyase Inhibitory Effect on E-Selectin.
Xu H, Wei K, Tu J, Chen Y, He Y, Ding Y, Xu H, Bao X, Xie H, Fang H, Wang H
Frontiers in cell and developmental biology 2021;9:741046
Frontiers in cell and developmental biology 2021;9:741046
Osteocyte Apoptosis Contributes to Cold Exposure-induced Bone Loss.
Du J, He Z, Cui J, Li H, Xu M, Zhang S, Zhang S, Yan M, Qu X, Yu Z
Frontiers in bioengineering and biotechnology 2021;9:733582
Frontiers in bioengineering and biotechnology 2021;9:733582
Exosomes Isolated From Bone Marrow Mesenchymal Stem Cells Exert a Protective Effect on Osteoarthritis via lncRNA LYRM4-AS1-GRPR-miR-6515-5p.
Wang X, Li Z, Cui Y, Cui X, Chen C, Wang Z
Frontiers in cell and developmental biology 2021;9:644380
Frontiers in cell and developmental biology 2021;9:644380
Leptin Induced TLR4 Expression via the JAK2-STAT3 Pathway in Obesity-Related Osteoarthritis.
Jiang M, He J, Sun Y, Dong X, Yao J, Gu H, Liu L
Oxidative medicine and cellular longevity 2021;2021:7385160
Oxidative medicine and cellular longevity 2021;2021:7385160
MCC950, the NLRP3 Inhibitor, Protects against Cartilage Degradation in a Mouse Model of Osteoarthritis.
Ni B, Pei W, Qu Y, Zhang R, Chu X, Wang Y, Huang X, You H
Oxidative medicine and cellular longevity 2021;2021:4139048
Oxidative medicine and cellular longevity 2021;2021:4139048
Bardoxolone-Methyl Prevents Oxidative Stress-Mediated Apoptosis and Extracellular Matrix Degradation in vitro and Alleviates Osteoarthritis in vivo.
Pang Z, Jiang Z, Zhu R, Song C, Tang H, Cao L, Guo C
Drug design, development and therapy 2021;15:3735-3747
Drug design, development and therapy 2021;15:3735-3747
Aberrant Fluid Shear Stress Contributes to Articular Cartilage Pathogenesis via Epigenetic Regulation of ZBTB20 by H3K4me3.
Jin Y, Li Z, Wu Y, Li H, Liu Z, Liu L, Ouyang N, Zhou T, Fang B, Xia L
Journal of inflammation research 2021;14:6067-6083
Journal of inflammation research 2021;14:6067-6083
Exosome-Encapsulated microRNA-127-3p Released from Bone Marrow-Derived Mesenchymal Stem Cells Alleviates Osteoarthritis Through Regulating CDH11-Mediated Wnt/β-Catenin Pathway.
Dong J, Li L, Fang X, Zang M
Journal of pain research 2021;14:297-310
Journal of pain research 2021;14:297-310
Isovitexin Depresses Osteoarthritis Progression via the Nrf2/NF-κB Pathway: An in vitro Study.
Hu X, Li R, Sun M, Kong Y, Zhu H, Wang F, Wan Q
Journal of inflammation research 2021;14:1403-1414
Journal of inflammation research 2021;14:1403-1414
Therapeutic Effects of Naringin in Rheumatoid Arthritis: Network Pharmacology and Experimental Validation.
Aihaiti Y, Song Cai Y, Tuerhong X, Ni Yang Y, Ma Y, Shi Zheng H, Xu K, Xu P
Frontiers in pharmacology 2021;12:672054
Frontiers in pharmacology 2021;12:672054
Exhausting circ_0136474 and Restoring miR-766-3p Attenuate Chondrocyte Oxidative Injury in IL-1β-Induced Osteoarthritis Progression Through Regulating DNMT3A.
Zhu H, Zhu S, Shang X, Meng X, Jing S, Yu L, Deng Y
Frontiers in genetics 2021;12:648709
Frontiers in genetics 2021;12:648709
MicroRNA-497 Reduction and Increase of Its Family Member MicroRNA-424 Lead to Dysregulation of Multiple Inflammation Related Genes in Synovial Fibroblasts With Rheumatoid Arthritis.
Wang S, Xu J, Guo Y, Cai Y, Ren X, Zhu W, Geng M, Meng L, Jiang C, Lu S
Frontiers in immunology 2021;12:619392
Frontiers in immunology 2021;12:619392
Injectable exosome-functionalized extracellular matrix hydrogel for metabolism balance and pyroptosis regulation in intervertebral disc degeneration.
Xing H, Zhang Z, Mao Q, Wang C, Zhou Y, Zhou X, Ying L, Xu H, Hu S, Zhang N
Journal of nanobiotechnology 2021 Sep 6;19(1):264
Journal of nanobiotechnology 2021 Sep 6;19(1):264
Integrative analysis of genome-wide DNA methylation and single-nucleotide polymorphism identified ACSM5 as a suppressor of lumbar ligamentum flavum hypertrophy.
Cao Y, Zhan Y, Qiu S, Chen Z, Gong K, Ni S, Duan Y
Arthritis research & therapy 2021 Sep 30;23(1):251
Arthritis research & therapy 2021 Sep 30;23(1):251
Asporin regulated by miR-26b-5p mediates chondrocyte senescence and exacerbates osteoarthritis progression via TGF-β1/Smad2 pathway.
Liu L, Zhao C, Zhang H, Lu Y, Luo B, Yao Z, Shao Y, Zeng H, Zeng C, Zhang R, Fang H, Pan J, Bai X, Cai D
Rheumatology (Oxford, England) 2021 Sep 24;
Rheumatology (Oxford, England) 2021 Sep 24;
18β-Glycyrrhetinic acid inhibits IL-1β-induced inflammatory response in mouse chondrocytes and prevents osteoarthritic progression by activating Nrf2.
Chen B, Zhu D, Xie C, Shi Y, Ni L, Zhang H, Li S, Lu J, Xiao J, Xia W, Huang C, Wang X
Food & function 2021 Sep 20;12(18):8399-8410
Food & function 2021 Sep 20;12(18):8399-8410
Therapeutic effect of neohesperidin on TNF-α-stimulated human rheumatoid arthritis fibroblast-like synoviocytes.
Wang XH, Dai C, Wang J, Liu R, Li L, Yin ZS
Chinese journal of natural medicines 2021 Oct;19(10):741-749
Chinese journal of natural medicines 2021 Oct;19(10):741-749
Frugoside delays osteoarthritis progression via inhibiting miR-155-modulated synovial macrophage M1 polarization.
Wang H, Zhang H, Fan K, Zhang D, Hu A, Zeng X, Liu YL, Tan G, Wang H
Rheumatology (Oxford, England) 2021 Oct 2;60(10):4899-4909
Rheumatology (Oxford, England) 2021 Oct 2;60(10):4899-4909
SP600125 Restored TNF-α-Induced Impaired Chondrogenesis in Bone Mesenchymal Stem Cells and Its Antiosteoarthritis Effect in Mice.
Ding N, Zeng MY, Song WJ, Xiao CX, Li EM, Wei B
Stem cells and development 2021 Oct 15;30(20):1028-1036
Stem cells and development 2021 Oct 15;30(20):1028-1036
Compressive force regulates cementoblast migration via downregulation of autophagy.
Yang Y, Huang Y, Liu H, Zheng Y, Jia L, Li W
Journal of periodontology 2021 Nov;92(11):128-138
Journal of periodontology 2021 Nov;92(11):128-138
Effects of mechanical stress and deficiency of dihydrotestosterone or 17β-estradiol on Temporomandibular Joint Osteoarthritis in mice.
Ootake T, Ishii T, Sueishi K, Watanabe A, Ishizuka Y, Amano K, Nagao M, Nishimura K, Nishii Y
Osteoarthritis and cartilage 2021 Nov;29(11):1575-1589
Osteoarthritis and cartilage 2021 Nov;29(11):1575-1589
Regulation of osteoarthritis development by ADAM17/Tace in articular cartilage.
Kaneko T, Horiuchi K, Chijimatsu R, Mori D, Nagata K, Omata Y, Yano F, Inui H, Moro T, Tanaka S, Saito T
Journal of bone and mineral metabolism 2021 Nov 9;
Journal of bone and mineral metabolism 2021 Nov 9;
MFG-E8 regulated by miR-99b-5p protects against osteoarthritis by targeting chondrocyte senescence and macrophage reprogramming via the NF-κB pathway.
Lu Y, Liu L, Pan J, Luo B, Zeng H, Shao Y, Zhang H, Guan H, Guo D, Zeng C, Zhang R, Bai X, Zhang H, Cai D
Cell death & disease 2021 May 25;12(6):533
Cell death & disease 2021 May 25;12(6):533
Decreased miR-214-3p activates NF-κB pathway and aggravates osteoarthritis progression.
Cao Y, Tang S, Nie X, Zhou Z, Ruan G, Han W, Zhu Z, Ding C
EBioMedicine 2021 Mar;65:103283
EBioMedicine 2021 Mar;65:103283
Senolytic agent Quercetin ameliorates intervertebral disc degeneration via the Nrf2/NF-κB axis.
Shao Z, Wang B, Shi Y, Xie C, Huang C, Chen B, Zhang H, Zeng G, Liang H, Wu Y, Zhou Y, Tian N, Wu A, Gao W, Wang X, Zhang X
Osteoarthritis and cartilage 2021 Mar;29(3):413-422
Osteoarthritis and cartilage 2021 Mar;29(3):413-422
d-Mannose suppresses osteoarthritis development in vivo and delays IL-1β-induced degeneration in vitro by enhancing autophagy activated via the AMPK pathway.
Lin Z, Miao J, Zhang T, He M, Zhou X, Zhang H, Gao Y, Bai L
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Mar;135:111199
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Mar;135:111199
Cardamonin protects nucleus pulposus cells against IL-1β-induced inflammation and catabolism via Nrf2/NF-κB axis.
Xie C, Ma H, Shi Y, Li J, Wu H, Wang B, Shao Z, Huang C, Chen J, Sun L, Zhou Y, Tian N, Wu Y, Gao W, Wu A, Wang X, Zhang X
Food & function 2021 Mar 21;12(6):2703-2714
Food & function 2021 Mar 21;12(6):2703-2714
Inhibition of HDAC6 by Tubastatin A reduces chondrocyte oxidative stress in chondrocytes and ameliorates mouse osteoarthritis by activating autophagy.
Shen Z, Ji K, Cai Z, Huang C, He X, Xu H, Chen G
Aging 2021 Mar 19;13(7):9820-9837
Aging 2021 Mar 19;13(7):9820-9837
BMP5 silencing inhibits chondrocyte senescence and apoptosis as well as osteoarthritis progression in mice.
Shao Y, Zhao C, Pan J, Zeng C, Zhang H, Liu L, Fan K, Liu X, Luo B, Fang H, Bai X, Zhang H, Cai D
Aging 2021 Mar 19;13(7):9646-9664
Aging 2021 Mar 19;13(7):9646-9664
Phgdh serves a protective role in Il‑1β induced chondrocyte inflammation and oxidative‑stress damage.
Huang H, Liu K, Ou H, Qian X, Wan J
Molecular medicine reports 2021 Jun;23(6)
Molecular medicine reports 2021 Jun;23(6)
AMD3465 (hexahydrobromide) rescues the MG63 osteoblasts against the apoptosis induced by high glucose.
Zhang Z, Wu H, Huang S, Chen L, Chen X, Zhang W, Liao L, Zhang X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jun;138:111476
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jun;138:111476
TGF-β/Alk5 signaling prevents osteoarthritis initiation via regulating the senescence of articular cartilage stem cells.
Tan Q, Wang Q, Kuang L, Zhang J, Peng X, Liang S, Liu M, Chen H, Chen S, Luo X, Qi H, Li C, Luo F, Huang S, Ni Z, Jin M, Su N, Yang J, Yang P, Chen B, Chen L, Du X, Xie Y, Chen L
Journal of cellular physiology 2021 Jul;236(7):5278-5292
Journal of cellular physiology 2021 Jul;236(7):5278-5292
α-Cyperone (CYP) down-regulates NF-κB and MAPKs signaling, attenuating inflammation and extracellular matrix degradation in chondrocytes, to ameliorate osteoarthritis in mice.
Zhang H, Li S, Lu J, Jin J, Zhu G, Wang L, Yan Y, He L, Wang B, Wang X, Yu H
Aging 2021 Jul 8;13(13):17690-17706
Aging 2021 Jul 8;13(13):17690-17706
Activation of transient receptor potential vanilloid 4 protects articular cartilage against inflammatory responses via CaMKK/AMPK/NF-κB signaling pathway.
Hattori K, Takahashi N, Terabe K, Ohashi Y, Kishimoto K, Yokota Y, Suzuki M, Kojima T, Imagama S
Scientific reports 2021 Jul 30;11(1):15508
Scientific reports 2021 Jul 30;11(1):15508
Metabolic reprogramming in chondrocytes to promote mitochondrial respiration reduces downstream features of osteoarthritis.
Ohashi Y, Takahashi N, Terabe K, Tsuchiya S, Kojima T, Knudson CB, Knudson W, Imagama S
Scientific reports 2021 Jul 23;11(1):15131
Scientific reports 2021 Jul 23;11(1):15131
LncRNA H19-Derived miR-675-5p Accelerates the Invasion of Extravillous Trophoblast Cells by Inhibiting GATA2 and Subsequently Activating Matrix Metalloproteinases.
Ogoyama M, Ohkuchi A, Takahashi H, Zhao D, Matsubara S, Takizawa T
International journal of molecular sciences 2021 Jan 27;22(3)
International journal of molecular sciences 2021 Jan 27;22(3)
The Role of Panx3 in Age-Associated and Injury-Induced Intervertebral Disc Degeneration.
Serjeant M, Moon PM, Quinonez D, Penuela S, Beier F, Séguin CA
International journal of molecular sciences 2021 Jan 22;22(3)
International journal of molecular sciences 2021 Jan 22;22(3)
Endoplasmic reticulum stress pathway mediates T-2 toxin-induced chondrocyte apoptosis.
Liu YN, Mu YD, Wang H, Zhang M, Shi YW, Mi G, Peng LX, Chen JH
Toxicology 2021 Dec;464:152989
Toxicology 2021 Dec;464:152989
Acetabular development and fate of inverted limbus in rabbits: Experimental observation from an animal model.
Liu J, Zhou W, Chen Y, Li L
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2021 Dec;39(12):2595-2603
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2021 Dec;39(12):2595-2603
Glucagon-like peptide-1 receptor activation maintains extracellular matrix integrity by inhibiting the activity of mitogen-activated protein kinases and activator protein-1.
Peng Y, Lin H, Tian S, Liu S, Li J, Lv X, Chen S, Zhao L, Pu F, Chen X, Shu H, Qing X, Shao Z
Free radical biology & medicine 2021 Dec;177:247-259
Free radical biology & medicine 2021 Dec;177:247-259
Silencing BLNK protects against interleukin-1β-induced chondrocyte injury through the NF-κB signaling pathway.
Cheng Y, Li F, Zhang WS, Zou GY, Shen YX
Cytokine 2021 Dec;148:155686
Cytokine 2021 Dec;148:155686
Role of the hippo signaling pathway in the extracellular matrix degradation of chondrocytes induced by fluoride exposure.
Yu FF, Zuo J, Fu X, Gao MH, Sun L, Yu SY, Li Z, Zhou GY, Ba Y
Ecotoxicology and environmental safety 2021 Dec 1;225:112796
Ecotoxicology and environmental safety 2021 Dec 1;225:112796
TGF-β1-stimulation of NFATC2 and ATF3 proteins and their interaction for matrix metalloproteinase 13 expression in human breast cancer cells.
Rohini M, Vairamani M, Selvamurugan N
International journal of biological macromolecules 2021 Dec 1;192:1325-1330
International journal of biological macromolecules 2021 Dec 1;192:1325-1330
Involvement of Transient Receptor Potential Vanilloid Channel 2 in the Induction of Lubricin and Suppression of Ectopic Endochondral Ossification in Mouse Articular Cartilage.
Nakamoto H, Katanosaka Y, Chijimatsu R, Mori D, Xuan F, Yano F, Omata Y, Maenohara Y, Murahashi Y, Kawaguchi K, Yamagami R, Inui H, Taketomi S, Taniguchi Y, Kanagawa M, Naruse K, Tanaka S, Saito T
Arthritis & rheumatology (Hoboken, N.J.) 2021 Aug;73(8):1441-1450
Arthritis & rheumatology (Hoboken, N.J.) 2021 Aug;73(8):1441-1450
Scleraxis expressing scleral cells respond to inflammatory stimulation.
Atta G, Schroedl F, Kaser-Eichberger A, Spitzer G, Traweger A, Heindl LM, Tempfer H
Histochemistry and cell biology 2021 Aug;156(2):123-132
Histochemistry and cell biology 2021 Aug;156(2):123-132
Suramin attenuates intervertebral disc degeneration by inhibiting NF-κB signalling pathway.
Liu ZM, Lu CC, Shen PC, Chou SH, Shih CL, Chen JC, Tien YC
Bone & joint research 2021 Aug;10(8):498-513
Bone & joint research 2021 Aug;10(8):498-513
METTL3 involves the progression of osteoarthritis probably by affecting ECM degradation and regulating the inflammatory response.
Sang W, Xue S, Jiang Y, Lu H, Zhu L, Wang C, Ma J
Life sciences 2021 Aug 1;278:119528
Life sciences 2021 Aug 1;278:119528
Oroxylin A attenuates IL-1β-induced inflammatory reaction via inhibiting the activation of the ERK and PI3K/AKT signaling pathways in osteoarthritis chondrocytes.
Zhang Y, Weng Q, Chen J, Li M, Han J
Experimental and therapeutic medicine 2021 Apr;21(4):388
Experimental and therapeutic medicine 2021 Apr;21(4):388
Effects of HDAC4 on IL-1β-induced matrix metalloproteinase expression regulated partially through the WNT3A/β-catenin pathway.
Ning Q, Gan YH, Shi RR, Meng JH
Chinese medical journal 2021 Apr 8;134(8):963-970
Chinese medical journal 2021 Apr 8;134(8):963-970
ZIP8 mediates the extracellular matrix degradation of nucleus pulposus cells via NF-κB signaling pathway.
Ding W, Ge Y, Sun H, Xu J, Gu H, Bian C, Chen H, Jiang L, Yin X
Biochemical and biophysical research communications 2021 Apr 23;550:30-36
Biochemical and biophysical research communications 2021 Apr 23;550:30-36
OPN Deficiency Increases the Severity of Osteoarthritis Associated with Aberrant Chondrocyte Senescence and Apoptosis and Upregulates the Expression of Osteoarthritis-Associated Genes.
Tian J, Cheng C, Kuang SD, Su C, Zhao X, Xiong YL, Li YS, Gao SG
Pain research & management 2020;2020:3428587
Pain research & management 2020;2020:3428587
Punicalagin Inhibits Tert-Butyl Hydroperoxide-Induced Apoptosis and Extracellular Matrix Degradation in Chondrocytes by Activating Autophagy and Ameliorates Murine Osteoarthritis.
Kong J, Wang J, Gong X, Zheng X, Chen T
Drug design, development and therapy 2020;14:5521-5533
Drug design, development and therapy 2020;14:5521-5533
LncRNA TRPC7-AS1 regulates nucleus pulposus cellular senescence and ECM synthesis via competing with HPN for miR-4769-5p binding.
Wang X, Li D, Wu H, Liu F, Liu F, Zhang Q, Li J
Mechanisms of ageing and development 2020 Sep;190:111293
Mechanisms of ageing and development 2020 Sep;190:111293
A chondroprotective effect of moracin on IL-1β-induced primary rat chondrocytes and an osteoarthritis rat model through Nrf2/HO-1 and NF-κB axes.
Zhou S, Shi J, Wen H, Xie W, Han X, Li H
Food & function 2020 Sep 23;11(9):7935-7945
Food & function 2020 Sep 23;11(9):7935-7945
TLR4 contributes to the damage of cartilage and subchondral bone in discectomy-induced TMJOA mice.
Liu X, Cai HX, Cao PY, Feng Y, Jiang HH, Liu L, Ke J, Long X
Journal of cellular and molecular medicine 2020 Oct;24(19):11489-11499
Journal of cellular and molecular medicine 2020 Oct;24(19):11489-11499
S-allyl cysteine reduces osteoarthritis pathology in the tert-butyl hydroperoxide-treated chondrocytes and the destabilization of the medial meniscus model mice via the Nrf2 signaling pathway.
Shao Z, Pan Z, Lin J, Zhao Q, Wang Y, Ni L, Feng S, Tian N, Wu Y, Sun L, Gao W, Zhou Y, Zhang X, Wang X
Aging 2020 Oct 7;12(19):19254-19272
Aging 2020 Oct 7;12(19):19254-19272
IL-37 inhibits M1-like macrophage activation to ameliorate temporomandibular joint inflammation through the NLRP3 pathway.
Luo P, Peng S, Yan Y, Ji P, Xu J
Rheumatology (Oxford, England) 2020 Oct 1;59(10):3070-3080
Rheumatology (Oxford, England) 2020 Oct 1;59(10):3070-3080
Heparan sulfate deficiency leads to hypertrophic chondrocytes by increasing bone morphogenetic protein signaling.
Kawashima K, Ogawa H, Komura S, Ishihara T, Yamaguchi Y, Akiyama H, Matsumoto K
Osteoarthritis and cartilage 2020 Nov;28(11):1459-1470
Osteoarthritis and cartilage 2020 Nov;28(11):1459-1470
miR-873-3p targets HDAC4 to stimulate matrix metalloproteinase-13 expression upon parathyroid hormone exposure in rat osteoblasts.
Malavika D, Shreya S, Raj Priya V, Rohini M, He Z, Partridge NC, Selvamurugan N
Journal of cellular physiology 2020 Nov;235(11):7996-8009
Journal of cellular physiology 2020 Nov;235(11):7996-8009
Reducing macrophage numbers alleviates temporomandibular joint ankylosis.
Zhao L, Xiao E, He L, Duan D, He Y, Chen S, Zhang Y, Gan Y
Cell and tissue research 2020 Mar;379(3):521-536
Cell and tissue research 2020 Mar;379(3):521-536
Oxymatrine suppresses IL-1β-induced degradation of the nucleus pulposus cell and extracellular matrix through the TLR4/NF-κB signaling pathway.
Wei K, Dai J, Wang Z, Pei Y, Chen Y, Ding Y, Ding Q, Ahati P, Zhou X, Wang H, Fang H
Experimental biology and medicine (Maywood, N.J.) 2020 Mar;245(6):532-541
Experimental biology and medicine (Maywood, N.J.) 2020 Mar;245(6):532-541
Paclitaxel-induced peripheral neuropathy is caused by epidermal ROS and mitochondrial damage through conserved MMP-13 activation.
Cirrincione AM, Pellegrini AD, Dominy JR, Benjamin ME, Utkina-Sosunova I, Lotti F, Jergova S, Sagen J, Rieger S
Scientific reports 2020 Mar 4;10(1):3970
Scientific reports 2020 Mar 4;10(1):3970
Long non-coding RNA SNHG15 is a competing endogenous RNA of miR-141-3p that prevents osteoarthritis progression by upregulating BCL2L13 expression.
Zhang X, Huang CR, Pan S, Pang Y, Chen YS, Zha GC, Guo KJ, Zheng X
International immunopharmacology 2020 Jun;83:106425
International immunopharmacology 2020 Jun;83:106425
Casticin Attenuates Osteoarthritis-Related Cartilage Degeneration by Inhibiting the ROS-Mediated NF-κB Signaling Pathway in vitro and in vivo.
Chu J, Yan B, Zhang J, Peng L, Ao X, Zheng Z, Jiang T, Zhang Z
Inflammation 2020 Jun;43(3):810-820
Inflammation 2020 Jun;43(3):810-820
Curcumol may reverse early and advanced liver fibrogenesis through downregulating the uPA/uPAR pathway.
Li G, Lin J, Peng Y, Qin K, Wen L, Zhao T, Feng Q
Phytotherapy research : PTR 2020 Jun;34(6):1421-1435
Phytotherapy research : PTR 2020 Jun;34(6):1421-1435
MicroRNA-675-3p regulates IL-1β-stimulated human chondrocyte apoptosis and cartilage degradation by targeting GNG5.
Shen XF, Cheng Y, Dong QR, Zheng MQ
Biochemical and biophysical research communications 2020 Jun 25;527(2):458-465
Biochemical and biophysical research communications 2020 Jun 25;527(2):458-465
The protective effect of myricitrin in osteoarthritis: An in vitro and in vivo study.
Yan Z, Lin Z, Wu Y, Zhan J, Qi W, Lin J, Shen J, Xue X, Pan X
International immunopharmacology 2020 Jul;84:106511
International immunopharmacology 2020 Jul;84:106511
MiR-455-3p reduces apoptosis and alleviates degeneration of chondrocyte through regulating PI3K/AKT pathway.
Wen X, Li H, Sun H, Zeng A, Lin R, Zhao J, Zhang Z
Life sciences 2020 Jul 15;253:117718
Life sciences 2020 Jul 15;253:117718
Hypoxic mast cells accelerate the proliferation, collagen accumulation and phenotypic alteration of human lung fibroblasts.
Wang X, Lin L, Chai X, Wu Y, Li Y, Liu X
International journal of molecular medicine 2020 Jan;45(1):175-185
International journal of molecular medicine 2020 Jan;45(1):175-185
Targeting exosome-associated human antigen R attenuates fibrosis and inflammation in diabetic heart.
Govindappa PK, Patil M, Garikipati VNS, Verma SK, Saheera S, Narasimhan G, Zhu W, Kishore R, Zhang J, Krishnamurthy P
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Feb;34(2):2238-2251
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Feb;34(2):2238-2251
MicroRNA-377-3p alleviates IL-1β-caused chondrocyte apoptosis and cartilage degradation in osteoarthritis in part by downregulating ITGA6.
Tu Y, Ma T, Wen T, Yang T, Xue L, Cai M, Wang F, Guan M, Xue H
Biochemical and biophysical research communications 2020 Feb 26;523(1):46-53
Biochemical and biophysical research communications 2020 Feb 26;523(1):46-53
Protective effect of resveratrol on obesity-related osteoarthritis via alleviating JAK2/STAT3 signaling pathway is independent of SOCS3.
Jiang M, He J, Gu H, Yang Y, Huang Y, Xu X, Liu L
Toxicology and applied pharmacology 2020 Feb 1;388:114871
Toxicology and applied pharmacology 2020 Feb 1;388:114871
Inhibition of PI3K/Akt/NF-κB signaling by Aloin for ameliorating the progression of osteoarthritis: In vitro and in vivo studies.
Zhang C, Shao Z, Hu X, Chen Z, Li B, Jiang R, Bsoul N, Chen J, Xu C, Gao W
International immunopharmacology 2020 Dec;89(Pt B):107079
International immunopharmacology 2020 Dec;89(Pt B):107079
Exogenous hydrogen sulfide inhibits apoptosis by regulating endoplasmic reticulum stress-autophagy axis and improves myocardial reconstruction after acute myocardial infarction.
Li Y, Liu M, Yi J, Song X, Zheng X, Liu D, Wang S, Chu C, Yang J
Acta biochimica et biophysica Sinica 2020 Dec 29;52(12):1325-1336
Acta biochimica et biophysica Sinica 2020 Dec 29;52(12):1325-1336
Stachydrine ameliorates the progression of intervertebral disc degeneration via the PI3K/Akt/NF-κB signaling pathway: in vitro and in vivo studies.
Shao Z, Lu J, Zhang C, Zeng G, Chen B, Liang H, Wu A, Zhang X, Wang X
Food & function 2020 Dec 1;11(12):10864-10875
Food & function 2020 Dec 1;11(12):10864-10875
Glycitin Suppresses Cartilage Destruction of Osteoarthritis in Mice.
Wang W, Yang R, Zhang M, Li J, Peng J, Xu M, Zhao Y, Li H, Pan X
Inflammation 2020 Aug;43(4):1312-1322
Inflammation 2020 Aug;43(4):1312-1322
Crenigacestat, a selective NOTCH1 inhibitor, reduces intrahepatic cholangiocarcinoma progression by blocking VEGFA/DLL4/MMP13 axis.
Mancarella S, Serino G, Dituri F, Cigliano A, Ribback S, Wang J, Chen X, Calvisi DF, Giannelli G
Cell death and differentiation 2020 Aug;27(8):2330-2343
Cell death and differentiation 2020 Aug;27(8):2330-2343
Macromechanics and polycaprolactone fiber organization drive macrophage polarization and regulate inflammatory activation of tendon in vitro and in vivo.
Schoenenberger AD, Tempfer H, Lehner C, Egloff J, Mauracher M, Bird A, Widmer J, Maniura-Weber K, Fucentese SF, Traweger A, Silvan U, Snedeker JG
Biomaterials 2020 Aug;249:120034
Biomaterials 2020 Aug;249:120034
Vitamin D3 protects articular cartilage by inhibiting the Wnt/β-catenin signaling pathway.
Yang T, Sun W, Duan YH, Sun YB, Ren YM, Hou WY, Tian MQ
Experimental and therapeutic medicine 2020 Aug;20(2):1775-1781
Experimental and therapeutic medicine 2020 Aug;20(2):1775-1781
IκB kinase α: an independent prognostic factor that promotes the migration and invasion of oral squamous cell carcinoma.
Lv S, Wang F, Wang K, Fan Y, Xu J, Zheng J, Zeng Y
The British journal of oral & maxillofacial surgery 2020 Apr;58(3):296-303
The British journal of oral & maxillofacial surgery 2020 Apr;58(3):296-303
Keratocytes promote corneal neovascularization through VEGFr3 induced by PPARα-inhibition.
Wang X, Tang L, Zhang Z, Li W, Chen Y
Experimental eye research 2020 Apr;193:107982
Experimental eye research 2020 Apr;193:107982
FTO promotes cell proliferation and migration in esophageal squamous cell carcinoma through up-regulation of MMP13.
Liu S, Huang M, Chen Z, Chen J, Chao Q, Yin X, Quan M
Experimental cell research 2020 Apr 1;389(1):111894
Experimental cell research 2020 Apr 1;389(1):111894
25-HC promotes hepatocellular carcinoma metastasis through up-regulation of TLR4 dependent FABP4.
Wang S, Yao Y, Wang X, Zheng G, Ouyang W, Chen W
American journal of cancer research 2019;9(10):2140-2155
American journal of cancer research 2019;9(10):2140-2155
A Compound of Chinese Herbs Protects against Alcoholic Liver Fibrosis in Rats via the TGF-β1/Smad Signaling Pathway.
Li X, Liu Y, Yue W, Tan Y, Wang H, Zhang L, Chen J
Evidence-based complementary and alternative medicine : eCAM 2019;2019:9121347
Evidence-based complementary and alternative medicine : eCAM 2019;2019:9121347
KLF2 Protects against Osteoarthritis by Repressing Oxidative Response through Activation of Nrf2/ARE Signaling In Vitro and In Vivo.
Gao X, Jiang S, Du Z, Ke A, Liang Q, Li X
Oxidative medicine and cellular longevity 2019;2019:8564681
Oxidative medicine and cellular longevity 2019;2019:8564681
Nobiletin Inhibits IL-1β-Induced Inflammation in Chondrocytes via Suppression of NF-κB Signaling and Attenuates Osteoarthritis in Mice.
Lin Z, Wu D, Huang L, Jiang C, Pan T, Kang X, Pan J
Frontiers in pharmacology 2019;10:570
Frontiers in pharmacology 2019;10:570
Targeting the IL-1β/IL-1Ra pathways for the aggregation of human islet amyloid polypeptide in an ex vivo organ culture system of the intervertebral disc.
Wu X, Liao Z, Wang K, Hua W, Liu X, Song Y, Zhang Y, Yang S, Yang C
Experimental & molecular medicine 2019 Sep 25;51(9):1-16
Experimental & molecular medicine 2019 Sep 25;51(9):1-16
Effects of simvastatin on matrix metalloproteinase regulation in IL-1β-induced SW1353 cells.
Cecen B, Keles D, Oktay G, Kozaci LD
Chemico-biological interactions 2019 Sep 1;310:108730
Chemico-biological interactions 2019 Sep 1;310:108730
Alleviation of murine osteoarthritis by deletion of the focal adhesion mechanosensitive adapter, Hic-5.
Miyauchi A, Kim-Kaneyama JR, Lei XF, Chang SH, Saito T, Haraguchi S, Miyazaki T, Miyazaki A
Scientific reports 2019 Oct 31;9(1):15770
Scientific reports 2019 Oct 31;9(1):15770
Development of a Mouse Model of Knee Osteoarthritis Based on Obesity and Bipedal Walking.
Son KM, Jung HA, Hong JI, Park IY, Kim HA
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2019 Nov;37(11):2411-2419
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2019 Nov;37(11):2411-2419
ZnO nanoparticles inhibit the activity of Porphyromonas gingivalis and Actinomyces naeslundii and promote the mineralization of the cementum.
Wang J, Du L, Fu Y, Jiang P, Wang X
BMC oral health 2019 May 14;19(1):84
BMC oral health 2019 May 14;19(1):84
25-HC decreases the sensitivity of human gastric cancer cells to 5-fluorouracil and promotes cells invasion via the TLR2/NF-κB signaling pathway.
Wang S, Yao Y, Rao C, Zheng G, Chen W
International journal of oncology 2019 Mar;54(3):966-980
International journal of oncology 2019 Mar;54(3):966-980
Cortistatin binds to TNF-α receptors and protects against osteoarthritis.
Zhao Y, Li Y, Qu R, Chen X, Wang W, Qiu C, Liu B, Pan X, Liu L, Vasilev K, Hayball J, Dong S, Li W
EBioMedicine 2019 Mar;41:556-570
EBioMedicine 2019 Mar;41:556-570
miR-100-5p-abundant exosomes derived from infrapatellar fat pad MSCs protect articular cartilage and ameliorate gait abnormalities via inhibition of mTOR in osteoarthritis.
Wu J, Kuang L, Chen C, Yang J, Zeng WN, Li T, Chen H, Huang S, Fu Z, Li J, Liu R, Ni Z, Chen L, Yang L
Biomaterials 2019 Jun;206:87-100
Biomaterials 2019 Jun;206:87-100
miR-93-5p attenuates IL-1β-induced chondrocyte apoptosis and cartilage degradation in osteoarthritis partially by targeting TCF4.
Xue H, Tu Y, Ma T, Wen T, Yang T, Xue L, Cai M, Wang F, Guan M
Bone 2019 Jun;123:129-136
Bone 2019 Jun;123:129-136
Adamts17 is involved in skeletogenesis through modulation of BMP-Smad1/5/8 pathway.
Oichi T, Taniguchi Y, Soma K, Oshima Y, Yano F, Mori Y, Chijimatsu R, Kim-Kaneyama JR, Tanaka S, Saito T
Cellular and molecular life sciences : CMLS 2019 Dec;76(23):4795-4809
Cellular and molecular life sciences : CMLS 2019 Dec;76(23):4795-4809
Quercetin alleviates rat osteoarthritis by inhibiting inflammation and apoptosis of chondrocytes, modulating synovial macrophages polarization to M2 macrophages.
Hu Y, Gui Z, Zhou Y, Xia L, Lin K, Xu Y
Free radical biology & medicine 2019 Dec;145:146-160
Free radical biology & medicine 2019 Dec;145:146-160
Reduced PDGF-AA in subchondral bone leads to articular cartilage degeneration after strenuous running.
Yao Z, Chen P, Wang S, Deng G, Hu Y, Lin Q, Zhang X, Yu B
Journal of cellular physiology 2019 Aug;234(10):17946-17958
Journal of cellular physiology 2019 Aug;234(10):17946-17958
Inhibition of Ihh Reverses Temporomandibular Joint Osteoarthritis via a PTH1R Signaling Dependent Mechanism.
Yang H, Zhang M, Liu Q, Zhang H, Zhang J, Lu L, Xie M, Chen D, Wang M
International journal of molecular sciences 2019 Aug 3;20(15)
International journal of molecular sciences 2019 Aug 3;20(15)
Effects of IL-1β on MMP-9 Expression in Cementoblast-Derived Cell Line and MMP-Mediated Degradation of Type I Collagen.
Du M, Wang Y, Liu Z, Wang L, Cao Z, Zhang C, Hao Y, He H
Inflammation 2019 Apr;42(2):413-425
Inflammation 2019 Apr;42(2):413-425
SIRT3 Activation by Dihydromyricetin Suppresses Chondrocytes Degeneration via Maintaining Mitochondrial Homeostasis.
Wang J, Wang K, Huang C, Lin D, Zhou Y, Wu Y, Tian N, Fan P, Pan X, Xu D, Hu J, Zhou Y, Wang X, Zhang X
International journal of biological sciences 2018;14(13):1873-1882
International journal of biological sciences 2018;14(13):1873-1882
mTOR-mediated inactivation of 4E-BP1, an inhibitor of translation, precedes cartilage degeneration in rat osteoarthritic knees.
Katsara O, Kolupaeva V
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2018 Oct;36(10):2728-2735
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2018 Oct;36(10):2728-2735
Differential effects of high-physiological oestrogen on the degeneration of mandibular condylar cartilage and subchondral bone.
Ye T, Sun D, Mu T, Chu Y, Miao H, Zhang M, Yang H, Liu Q, Lu L, Xing X, Yu S
Bone 2018 Jun;111:9-22
Bone 2018 Jun;111:9-22
Loss of Fgfr1 in chondrocytes inhibits osteoarthritis by promoting autophagic activity in temporomandibular joint.
Wang Z, Huang J, Zhou S, Luo F, Tan Q, Sun X, Ni Z, Chen H, Du X, Xie Y, Chen L
The Journal of biological chemistry 2018 Jun 8;293(23):8761-8774
The Journal of biological chemistry 2018 Jun 8;293(23):8761-8774
ETV4 transcription factor and MMP13 metalloprotease are interplaying actors of breast tumorigenesis.
Dumortier M, Ladam F, Damour I, Vacher S, Bièche I, Marchand N, de Launoit Y, Tulasne D, Chotteau-Lelièvre A
Breast cancer research : BCR 2018 Jul 11;20(1):73
Breast cancer research : BCR 2018 Jul 11;20(1):73
Postnatal deletion of Alk5 gene in meniscal cartilage accelerates age-dependent meniscal degeneration in mice.
Wang Q, Tan Q, Xu W, Kuang L, Zhang B, Wang Z, Ni Z, Su N, Jin M, Li C, Jiang W, Huang J, Li F, Zhu Y, Chen H, Du X, Chen D, Deng C, Qi H, Xie Y, Chen L
Journal of cellular physiology 2018 Jan;234(1):595-605
Journal of cellular physiology 2018 Jan;234(1):595-605
Toxoplasma gondii GRA15II effector-induced M1 cells ameliorate liver fibrosis in mice infected with Schistosomiasis japonica.
Xie Y, Wen H, Yan K, Wang S, Wang X, Chen J, Li Y, Xu Y, Zhong Z, Shen J, Chu D
Cellular & molecular immunology 2018 Feb;15(2):120-134
Cellular & molecular immunology 2018 Feb;15(2):120-134
Emodin ameliorates cartilage degradation in osteoarthritis by inhibiting NF-κB and Wnt/β-catenin signaling in-vitro and in-vivo.
Ding QH, Ye CY, Chen EM, Zhang W, Wang XH
International immunopharmacology 2018 Aug;61:222-230
International immunopharmacology 2018 Aug;61:222-230
Tumor-derived exosomes educate dendritic cells to promote tumor metastasis via HSP72/HSP105-TLR2/TLR4 pathway.
Shen Y, Guo D, Weng L, Wang S, Ma Z, Yang Y, Wang P, Wang J, Cai Z
Oncoimmunology 2017;6(12):e1362527
Oncoimmunology 2017;6(12):e1362527
Chondroprotective Effects and Multitarget Mechanisms of Fu Yuan Capsule in a Rat Osteoarthritis Model.
Zeng L, Xiao CZ, Deng ZT, Li RH
Evidence-based complementary and alternative medicine : eCAM 2017;2017:8985623
Evidence-based complementary and alternative medicine : eCAM 2017;2017:8985623
Upregulation of FBXW7 Suppresses Renal Cancer Metastasis and Epithelial Mesenchymal Transition.
Cai Y, Zhang M, Qiu X, Wang B, Fu Y, Zeng J, Bai J, Yang G
Disease markers 2017;2017:8276939
Disease markers 2017;2017:8276939
Cartilage-specific deletion of Alk5 gene results in a progressive osteoarthritis-like phenotype in mice.
Wang Q, Tan QY, Xu W, Qi HB, Chen D, Zhou S, Ni ZH, Kuang L, Guo JY, Huang JL, Wang XX, Wang ZQ, Su N, Chen L, Chen B, Jiang WL, Gao Y, Chen HG, Du XL, Xie YL, Chen L
Osteoarthritis and cartilage 2017 Nov;25(11):1868-1879
Osteoarthritis and cartilage 2017 Nov;25(11):1868-1879
Icariin inhibits MMP‑1, MMP‑3 and MMP‑13 expression through MAPK pathways in IL‑1β‑stimulated SW1353 chondrosarcoma cells.
Zeng L, Rong XF, Li RH, Wu XY
Molecular medicine reports 2017 May;15(5):2853-2858
Molecular medicine reports 2017 May;15(5):2853-2858
Simvastatin Inhibits IL-1β-Induced Apoptosis and Extracellular Matrix Degradation by Suppressing the NF-kB and MAPK Pathways in Nucleus Pulposus Cells.
Tu J, Li W, Zhang Y, Wu X, Song Y, Kang L, Liu W, Wang K, Li S, Hua W, Yang C
Inflammation 2017 Jun;40(3):725-734
Inflammation 2017 Jun;40(3):725-734
Potential Involvement of the IL-6/JAK/STAT3 Pathway in the Pathogenesis of Intervertebral Disc Degeneration.
Suzuki S, Fujita N, Fujii T, Watanabe K, Yagi M, Tsuji T, Ishii K, Miyamoto T, Horiuchi K, Nakamura M, Matsumoto M
Spine 2017 Jul 15;42(14):E817-E824
Spine 2017 Jul 15;42(14):E817-E824
AMPK deficiency in chondrocytes accelerated the progression of instability-induced and ageing-associated osteoarthritis in adult mice.
Zhou S, Lu W, Chen L, Ge Q, Chen D, Xu Z, Shi D, Dai J, Li J, Ju H, Cao Y, Qin J, Chen S, Teng H, Jiang Q
Scientific reports 2017 Feb 22;7:43245
Scientific reports 2017 Feb 22;7:43245
Chlorogenic acid prevents inflammatory responses in IL‑1β‑stimulated human SW‑1353 chondrocytes, a model for osteoarthritis.
Liu CC, Zhang Y, Dai BL, Ma YJ, Zhang Q, Wang Y, Yang H
Molecular medicine reports 2017 Aug;16(2):1369-1375
Molecular medicine reports 2017 Aug;16(2):1369-1375
Conditional knockdown of hyaluronidase 2 in articular cartilage stimulates osteoarthritic progression in a mice model.
Higuchi Y, Nishida Y, Kozawa E, Zhuo L, Arai E, Hamada S, Morita D, Ikuta K, Kimata K, Ushida T, Ishiguro N
Scientific reports 2017 Aug 1;7(1):7028
Scientific reports 2017 Aug 1;7(1):7028
Fibroblast Growth Factor Receptor 3 Inhibits Osteoarthritis Progression in the Knee Joints of Adult Mice.
Tang J, Su N, Zhou S, Xie Y, Huang J, Wen X, Wang Z, Wang Q, Xu W, Du X, Chen H, Chen L
Arthritis & rheumatology (Hoboken, N.J.) 2016 Oct;68(10):2432-43
Arthritis & rheumatology (Hoboken, N.J.) 2016 Oct;68(10):2432-43
Iron overload in a murine model of hereditary hemochromatosis is associated with accelerated progression of osteoarthritis under mechanical stress.
Camacho A, Simão M, Ea HK, Cohen-Solal M, Richette P, Branco J, Cancela ML
Osteoarthritis and cartilage 2016 Mar;24(3):494-502
Osteoarthritis and cartilage 2016 Mar;24(3):494-502
Conditional knockout of tissue factor pathway inhibitor 2 in vascular endothelial cells accelerates atherosclerotic plaque development in mice.
Hong J, Liu R, Chen L, Wu B, Yu J, Gao W, Pan J, Luo X, Shi H
Thrombosis research 2016 Jan;137:148-156
Thrombosis research 2016 Jan;137:148-156
Exogenous fibroblast growth factor 9 attenuates cartilage degradation and aggravates osteophyte formation in post-traumatic osteoarthritis.
Zhou S, Wang Z, Tang J, Li W, Huang J, Xu W, Luo F, Xu M, Wang J, Wen X, Chen L, Chen H, Su N, Shen Y, Du X, Xie Y, Chen L
Osteoarthritis and cartilage 2016 Dec;24(12):2181-2192
Osteoarthritis and cartilage 2016 Dec;24(12):2181-2192
Conditional Deletion of Fgfr3 in Chondrocytes leads to Osteoarthritis-like Defects in Temporomandibular Joint of Adult Mice.
Zhou S, Xie Y, Li W, Huang J, Wang Z, Tang J, Xu W, Sun X, Tan Q, Huang S, Luo F, Xu M, Wang J, Wu T, Chen L, Chen H, Su N, Du X, Shen Y, Chen L
Scientific reports 2016 Apr 4;6:24039
Scientific reports 2016 Apr 4;6:24039
Levofloxacin increases apoptosis of rat annulus fibrosus cells via the mechanism of upregulating MMP-2 and MMP-13.
Wei HK, Yang SD, Bai ZL, Zhang X, Yang DL, Ding WY
International journal of clinical and experimental medicine 2015;8(11):20198-207
International journal of clinical and experimental medicine 2015;8(11):20198-207
Deletion of Dual Specificity Phosphatase 1 Does Not Predispose Mice to Increased Spontaneous Osteoarthritis.
Pest MA, Pest CA, Bellini MR, Feng Q, Beier F
PloS one 2015;10(11):e0142822
PloS one 2015;10(11):e0142822
17β-estradiol protects against apoptosis induced by interleukin-1β in rat nucleus pulposus cells by down-regulating MMP-3 and MMP-13.
Yang SD, Yang DL, Sun YP, Wang BL, Ma L, Feng SQ, Ding WY
Apoptosis : an international journal on programmed cell death 2015 Mar;20(3):348-57
Apoptosis : an international journal on programmed cell death 2015 Mar;20(3):348-57
Deletion of Panx3 Prevents the Development of Surgically Induced Osteoarthritis.
Moon PM, Penuela S, Barr K, Khan S, Pin CL, Welch I, Attur M, Abramson SB, Laird DW, Beier F
Journal of molecular medicine (Berlin, Germany) 2015 Aug;93(8):845-56
Journal of molecular medicine (Berlin, Germany) 2015 Aug;93(8):845-56
Potent effects of dioscin against liver fibrosis.
Zhang X, Han X, Yin L, Xu L, Qi Y, Xu Y, Sun H, Lin Y, Liu K, Peng J
Scientific reports 2015 Apr 8;5:9713
Scientific reports 2015 Apr 8;5:9713
Keratocytes create stromal spaces to promote corneal neovascularization via MMP13 expression.
Ma J, Zhou D, Fan M, Wang H, Huang C, Zhang Z, Wu Y, Li W, Chen Y, Liu Z
Investigative ophthalmology & visual science 2014 Sep 4;55(10):6691-703
Investigative ophthalmology & visual science 2014 Sep 4;55(10):6691-703
Protective effects of biochanin A on articular cartilage: in vitro and in vivo studies.
Wu DQ, Zhong HM, Ding QH, Ba L
BMC complementary and alternative medicine 2014 Nov 15;14:444
BMC complementary and alternative medicine 2014 Nov 15;14:444
Chondroprotective effects and multi-target mechanisms of Icariin in IL-1 beta-induced human SW 1353 chondrosarcoma cells and a rat osteoarthritis model.
Zeng L, Wang W, Rong XF, Zhong Y, Jia P, Zhou GQ, Li RH
International immunopharmacology 2014 Jan;18(1):175-81
International immunopharmacology 2014 Jan;18(1):175-81
Loss of Vhl in cartilage accelerated the progression of age-associated and surgically induced murine osteoarthritis.
Weng T, Xie Y, Yi L, Huang J, Luo F, Du X, Chen L, Liu C, Chen D, Chen L
Osteoarthritis and cartilage 2014 Aug;22(8):1197-205
Osteoarthritis and cartilage 2014 Aug;22(8):1197-205
Suppression of hyaluronan synthesis alleviates inflammatory responses in murine arthritis and in human rheumatoid synovial fibroblasts.
Yoshioka Y, Kozawa E, Urakawa H, Arai E, Futamura N, Zhuo L, Kimata K, Ishiguro N, Nishida Y
Arthritis and rheumatism 2013 May;65(5):1160-70
Arthritis and rheumatism 2013 May;65(5):1160-70
Celastrol, an inhibitor of heat shock protein 90β potently suppresses the expression of matrix metalloproteinases, inducible nitric oxide synthase and cyclooxygenase-2 in primary human osteoarthritic chondrocytes.
Ding QH, Cheng Y, Chen WP, Zhong HM, Wang XH
European journal of pharmacology 2013 May 15;708(1-3):1-7
European journal of pharmacology 2013 May 15;708(1-3):1-7
Anti-arthritic effects of crocin in interleukin-1β-treated articular chondrocytes and cartilage in a rabbit osteoarthritic model.
Ding Q, Zhong H, Qi Y, Cheng Y, Li W, Yan S, Wang X
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2013 Jan;62(1):17-25
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2013 Jan;62(1):17-25
Genetic inhibition of fibroblast growth factor receptor 1 in knee cartilage attenuates the degeneration of articular cartilage in adult mice.
Weng T, Yi L, Huang J, Luo F, Wen X, Du X, Chen Q, Deng C, Chen D, Chen L
Arthritis and rheumatism 2012 Dec;64(12):3982-92
Arthritis and rheumatism 2012 Dec;64(12):3982-92
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- MDA-MB-453s cells were subjected to SDS PAGE followed by western blot with 18165-1-AP( MMP13 Antibody) at dilution of 1:600
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human breast cancer using 18165-1-AP(MMP13 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The MMP13 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human MMP13. This antibody recognizes human,mouse,rat,zebrafish antigen. The MMP13 antibody has been validated for the following applications: ELISA, IHC, WB analysis.