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- Product number
- 18165-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#18165-1-AP, RRID:AB_2144858
- Product name
- MMP13 antibody
- Antibody type
- Polyclonal
- Description
- MMP13 antibody (Cat. #18165-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Chondroitin sulfate alleviates osteoarthritis by upregulating HSPA8 to inhibit chondrocyte ferroptosis.
MSC Exosomes and Rutin-Chitosan-Pectin Nanoparticles Synergize to Ameliorate Adjuvant Arthritis via Th1/Th2 Modulation, MMP Suppression, Nrf2 Upregulation, and Antioxidant Boost.
Mitochondrial Dynamics Disorder Drives Nucleus Pulposus Cell Senescence in Lumbar Scoliosis of Aging Bipedal Rats Under Asymmetric Force.
Artemisinin exerts anti-inflammatory effects in osteoarthritis through the inhibition of TGF-β1 signaling.
Dissolvable microneedles loaded with denosumab alleviate knee osteoarthritis in rodent and canine models by inhibiting macrophage senescence.
Quercetin attenuates tendon stem/progenitor cell senescence and promotes aged tendon repair via AKT/NF-κB/NLRP3-mediated mitophagy activation.
Astragalus membranaceus Polysaccharides Attenuate Osteoarthritis in Human Primary Chondrocytes and in Animal Model: Mechanism Study Using RNA-Seq and Network Pharmacology.
Cinnamyl Alcohol Attenuates Osteoarthritis Progression via PIGR-Mediated Regulation of Chondrocyte Senescence and Cartilage Homeostasis.
Detoxification of T-2 toxin in human chondrocytes due to its hydroxylation by carboxylesterases and arylacetamide deacetylase in the liver.
Alzheimer's Disease Risk Factor APOE4 Exerts Dimorphic Effects on Female Bone.
Targeted knockdown of Piezo1 in synovial macrophages attenuates osteoarthritis development.
Hypoxia-preconditioned bone marrow mesenchymal stem cell-derived exosomes ameliorate knee osteoarthritis by promoting cartilage regeneration and alleviating pain in rats.
A novel MMP13 frameshift variant causes short stature via enhanced MMP13-HSPA5 interaction and activated endoplasmic reticulum stress.
The TRAF6/SPP1 axis participates in osteoarthritis progression through regulating the catabolism and anabolism of cartilage matrix.
Phellopterin Inhibits Inflammation and Relieves Cartilage Degradation by Suppressing MAPK Signaling in Osteoarthritis.
Natural photosynthetic system for restoring homeostasis of animal organelle interaction network.
Immunomodulatory and anabolic biphasic scaffold with hierarchical biomimetic structure directed osteochondral defect repair.
α-Ketoglutarate protects against cartilage damage via epigenetically driven metabolic reprogramming in osteoarthritis models.
Increased Expression of Connexin 43 Promotes Wnt/β-Catenin Signaling and the Progression of Temporomandibular Joint Osteoarthritis.
Phycocyanin-functionalized selenium nanoparticles attenuate osteoarthritis through ferroptosis suppression and modulation of the MAPK pathway.
Membrane-camouflaged nanoparticle alleviates intervertebral disc degeneration via oxidative stress suppression and autophagy activation.
Therapeutic effects of Tetramethylpyrazine on Cartilage in Rat Model of Post-traumatic Osteoarthritis.
ALOX5 knockdown alleviates cartilage damage in osteoarthritis by inhibiting the NF-κB signaling pathway.
Pterostilbene inhibits ferritinophagy-mediated ferroptosis via the NRF2/NCOA4/FTH1 axis and alleviates intervertebral disc degeneration through nanoliposomal delivery.
VDAC1-mediated cytosolic leakage of mtDNA triggers pyroptosis of nucleus pulposus cells by activating the TLR9 signaling pathway.
Long-acting triamcinolone acetonide prodrug microcrystals for sustained intra-articular treatment of osteoarthritis.
Artificial mitochondria ameliorates osteoarthritis through restoring cellular energy metabolism homeostasis.
Collagen II hydrogel-mediated sustained delivery of lacosamide attenuates cartilage degeneration and pain in osteoarthritis.
YAP in synovial macrophages mitigates mechanically-induced osteoarthritis by preserving mitochondrial fusion.
Targeting of CIRP attenuates osteoarthritis progression via suppressing TLR4/NF‑κB/NLRP3 signaling axis.
Intermittent intra-articular delivery of FGF8b enhances cartilage homeostasis and attenuates osteoarthritis progression.
Early Intervention of Subchondral Bone Resorption Mitigates Cartilage Degeneration in TMJOA.
Dual-PPARα/δ agonist H11 alleviates tendinopathy via modulating the Nrf2/HO-1/GPX4 pathway.
Pharmacological inhibition of PGK1 by genipin reduces inflammation and oxidative damage in osteoarthritis.
An injectable dihydroartemisinin nanocomposite hydrogel for dual-targeting PANoptosis and inflammation to treat osteoarthritis.
PTPN22 as a therapeutic target in intervertebral disc degeneration: Modulating mitophagy and pyroptosis through the PI3K/AKT/mTOR axis.
Promoter Methylation of WIF1 is Involved in IL-17-Induced Chondrocyte Inflammatory Injury and Matrix Degradation via Promoting Wnt5a/MAPK-JNK Signaling.
Injectable microgels loaded with programmable WELNs based on mendelian randomization macroanalysis alleviate osteoarthritis by restoring the circadian rhythm.
Integrating TWAS, chemical-genomic networks, and experimental models: melatonin as a ferroptosis inhibitor in osteoarthritis therapy.
Protopine attenuates hepatic fibrosis via HDAC6-mediated NLRP3 inflammasome activation.
NSUN3-mediated m5C modification of FABP5 regulates lipid droplets through autophagy to alleviate osteoarthritis progression.
Oxysophoridine promotes osteoarthritis repair via GSH system activation and ROS suppression.
Paeoniflorin Alleviates Metabolic Dysfunction-Associated Steatotic Liver Disease by Inhibiting Hepatic Lipogenesis and Inflammation.
Glibenclamide attenuates osteoarthritis by suppressing NLRP3 inflammasome activation in synovial macrophages through the MAPK pathway.
Synergistic Effects of Nutritional Formula on Joint Inflammation Through Modulation of Bone Metabolism in Rats.
Activated Rac1 promotes chondrocyte apoptosis through the NF-κB pathway in lumbar facet joint osteoarthritis.
High-intensity interval training remodels perineuronal nets in the medial prefrontal cortex to drive microglial polarization and alleviate osteoarthritis pain.
Synergistic microenvironment therapy: a dual-function nanogel of supramolecular collagen ll-mimetic matrix and antioxidant MXene for attenuating intervertebral disc degeneration.
CCL11 promotes hepatocellular carcinoma recurrence after surgery by potentiating immunosuppressive CCR5 + CD206 + M2-like macrophages and promoting tumor invasiveness.
Synovial inflammatory macrophage-derived extracellular vesicles exacerbate cartilage lesions with a FMRP-selectively sorted manner in osteoarthritis.
KLK8 promotes cartilage degradation and pyroptosis in osteoarthritis by activating the NF-κB and NLRP3 inflammasome pathways.
RP13-516M14.1 Regulates Autophagy Through miR-429 via Both a ceRNA Network and Direct Interaction.
Injectable microgels carrying engineered biomimetic nanoparticles for osteoarthritis therapy via dual-targeted senescent chondrocyte clearance and endogenous repair promotion.
An intelligent nanoliposome alleviates disc degeneration and discogenic pain by inhibiting neurovascular ingrowth via a "Soil-conditioning, seed-modulating, and weeds-suppressing" strategy.
Therapeutic effects of hypoxia-preconditioned cartilage progenitor cell-exosomes on osteoarthritis through autophagy activation and macrophage polarization modulation.
An engineered triple-network alginate/gelatin hydrogel mediates osteochondral regeneration through temporal regulation of the PI3K-AKT pathway.
Osteocyte-Intrinsic MMP13 exacerbates injury-induced temporomandibular joint osteoarthritis.
Hsa_circ_0101645 contributes to excessive autophagy and apoptosis in intervertebral disc degeneration by acting as a miR-1304-5p sponge modulating BNIP3 expression.
Pyrroloquinoline quinone alleviates age-related osteoarthritis via nuclear factor erythroid 2-related factor 2-mediated stress response and insulin-like growth factor 1 receptor upregulation.
Targeting adipocyte ESRRA alleviates osteoarthritis via interrupting inter-organelle crosstalk of complement C3-CFD-MAC cascade.
Identification of Autophagy-related Genes of the Osteoarthritis Using Machine Learning Algorithm.
Piezo2 Mediates a Vicious Cycle of "Mechanical Homeostasis Imbalance-Inflammation" in Sensory Nerves and the Cartilage Endplate.
A Pathological Microenvironment-Responsive Catalytic Carbon Nanodots Release Platform Intercepting the ROS-Inflammation Cascade to Alleviate Intervertebral Disc Degeneration.
HDAC6 exacerbates osteoarthritis by promoting macrophage inflammation-mediated chondrocyte degeneration.
Decoding Endoplasmic Reticulum Stress on Chondrocyte Driving Osteoarthritis Development through Integrating Single-Cell and Transcriptomic Profiling.
Identification of the key role of IL-17RB in the treatment of osteoarthritis with Shaoyao Gancao decoction: Verification based on RNA-seq and bioinformatics analysis.
Stigmasterol alleviates endplate chondrocyte degeneration through inducing mitophagy by enhancing PINK1 mRNA acetylation via the ESR1/NAT10 axis.
Microfluidic Synthesis of miR-200c-3p Lipid Nanoparticles: Targeting ZEB2 to Alleviate Chondrocyte Damage in Osteoarthritis.
Adipose Tissue-Derived Exosome Maintains Metabolic Balance of Extracellular Matrix in Rat Nucleus Pulposus Cells.
Enhancing Cartilage Repair in Osteoarthritis Using Platelet Lysates and Arthroscopic Microfracture.
Comparison of passive and active motion: effect of myokine irisin on cartilage in knee osteoarthritis rats.
Passive hydrotherapy preserves cartilage and muscle integrity in a murine osteoarthritis model: potential role of integrin αV/TGF-β mechanotransduction.
IL-19 suppresses Hippo signaling via modulating YAP1 phosphorylation in osteoarthritis.
Paeonol ameliorates ferroptosis and inflammation in chondrocytes through AMPK/Nrf2/GPX4 pathway.
Bone remodeling stimulated by Wnt-mediated mitophagy regulated extracellular vesicles in subchondral bone contributes to osteoarthritis development.
A strategy targeting ferroptosis for mitochondrial reprogramming and intervertebral disc degeneration therapy.
GLSP mitigates vascular aging by promoting Sirt7-mediated Keap1 deacetylation and Keap1-Nrf2 dissociation.
Lysyl Oxidase-Like 1 (LOXL1) Up-Regulation in Chondrocytes Promotes M1 Macrophage Activation in Osteoarthritis via NF-κB and STAT3 Signaling.
Hypoxia, cuproptosis, and osteoarthritis: Unraveling the molecular crosstalk.
TRPM2-mediated feed-forward loop promotes chondrocyte damage in osteoarthritis via calcium-cGAS-STING-NF-κB pathway.
Oxidative stress activates YAP/TEAD1/NCOA4 axis to promote ferroptosis of endplate chondrocytes and aggravate intervertebral disc degeneration.
Primary cilia in growth plates orchestrate long bone development.
Targeted Blockage of Pathological Extracellular Vesicles and Particles From Fibroblast-Like Synoviocytes for Osteoarthritis Relief: Proteomic Analysis and Cellular Effect.
Tryptophan metabolic dysregulation drives immune activation and cartilage degradation in osteoarthritis: Functional validation integrated with transcriptomic and single-cell RNA sequencing.
BRD-K20733377 inhibits ferroptosis and alleviates intervertebral disc degeneration via the STAT3/NFKB1 axis: a multiapproach study.
IRS2/FOXO1 mitigates osteoarthritis by regulating chondrocyte autophagy and mitochondrial function.
Circular RNA-based protein replacement therapy mitigates osteoarthritis in male mice.
Duhuo jisheng decoction alleviates osteoarthritis progression by mitigating ferroptosis in chondrocytes via the nuclear factor erythroid 2-related factor 2/glutathione peroxidase 4 axis.
Enhanced disc regeneration through CRISPR/Cas9-mediated SOX9 and TGFβ1 coexpression in tonsil-derived mesenchymal stromal cells.
Comparison of the therapeutic efficacy of leukocyte-poor and leukocyte-rich platelet-rich plasma in rabbit knee osteoarthritis and the study of autophagy mechanism.
Paeoniflorin mitigates iron overload-induced osteoarthritis by suppressing chondrocyte ferroptosis via the p53/SLC7A11/GPX4 pathway.
A hydrogel-based drug delivery system reduces inflammation and oxidative stress to alleviate intervertebral disc degeneration.
Sodium tanshinone IIA sulfonate alleviates osteoarthritis through targeting SIRT1.
cZFP609 Tethering BiP Alleviates Cartilage Degradation in Osteoarthritis via Remedying Aberrant ER-Mitochondrial Contacts.
Seeds-and-soil inspired hydrogel microspheres: A dual-action antioxidant and cellular therapy for reversing intervertebral disc degeneration.
Magnoflorine ameliorates cartilage degradation in osteoarthritis through inhibition of mitochondrial reactive oxygen species-mediated activation of the NLRP3 inflammasome.
Duhuo Jisheng decoction alleviates intervertebral disc degeneration by inhibiting nucleus pulposus cell ferroptosis via the exosome-mediated miR-19b-3p/ACSL4 axis.
Rabbits as preclinical animal models of cam morphology: proof of concept.
Therapeutic effects of Bushen Chushi formula on knee osteoarthritis via modulation of MAPK/SLC7A11/GPX4 signaling in rats.
Genotype and phenotype correlation analysis in 27 families with multiple osteochondroma and validation by ATDC5 chondrocyte models.
Paeonol reduces IL-1β induced apoptosis and degeneration by regulating MAPK pathway in nucleus pulposus cells.
Galangin Alleviates Intervertebral Disc Degeneration via the Nrf2/NF-κB Pathway.
Cytosolic phospholipase A2 as a therapeutic target for degenerative joint diseases.
Conjoint analysis of single-cell sequencing and high-throughput virtual screening regarding DDR2 in osteoarthritis disease models.
CORM-3 mitigates osteoarthritis by anti-inflammation and enhancing autophagy via inhibiting MAPK and mTOR pathways.
Circular RNA PVT1 promotes osteoarthritis progression through the miR-550a-3p/CX3CR1 pathway: A mechanistic study.
Upregulation of ACSL1 in synovial macrophages promotes lipid peroxidation via the IκB/NF-κB pathway to accelerate osteoarthritis.
Cuproptosis in osteoarthritis: Exploring chondrocyte cuproptosis and therapeutic avenues.
An aptamer specifically targeting mCRP ameliorates experimental arthritis.
Investigate the Regulatory Role of Parathyroid Hormone on Condylar Fibrocartilage Homeostasis.
Blocking Fpr3 ameliorates osteoarthritis by inhibiting NLRP3-mediated chondrocyte pyroptosis.
High-intensity running exercise promotes knee meniscal damage via the PI3K/AKT/mTOR axis.
KLF5 aggravates osteoarthritis progression by inhibiting chondrocyte autophagy via transcriptional activation of PLK2.
Lineage plasticity and signal dysregulation define the cellular trajectory of osteoarthritis progression.
FoxO1/PINK1/Parkin-dependent mitophagy mediates the chondroprotective effect of Guzhi Zengsheng Zhitong decoction in osteoarthritis.
Targeting ICAM1 through LIF-mediated NF-κB/JAK2-STAT3 crosstalk protects nucleus pulposus from IL-1β-driven pyroptosis to ameliorate intervertebral disc degeneration.
Targeting the ROS-ferroptosis-inflammation cycle with a nanozyme-functionalized hydrogel for intervertebral disc repair.
The Effect of Platelet-Rich Plasma on Synovial Fibrosis and Cartilage Degeneration in Knee Osteoarthritis.
SHP2-mediated ROS activation induces chondrocyte paraptosis in osteoarthritis and is attenuated by low-intensity pulsed ultrasound.
Cohesin Complex Interacting with Promoters of MMP Genes for in Pterygium Occurrence.
UGDH Lactylation Aggravates Osteoarthritis by Suppressing Glycosaminoglycan Synthesis and Orchestrating Nucleocytoplasmic Transport to Activate MAPK Signaling.
Cell-Free Fat Extract for the Treatment of Lumbar Disc Degeneration: A Novel Approach Using Adipose-Derived Biologic.
Dihydrotestosterone and 17β-estradiol modulate TMJ osteoarthritis development and reveal sex-specific differences in pathogenesis.
NOXA exacerbates endoplasmic-reticulum-stress-induced intervertebral disc degeneration by activating apoptosis and ECM degradation.
Osteocyte-derived extracellular vesicles mediate the bone-to-cartilage crosstalk and promote osteoarthritis progression.
Nicotinamide Adenine Dinucleotide-Loaded Lubricated Hydrogel Microspheres with a Three-Pronged Approach Alleviate Age-Related Osteoarthritis.
Streamlined metal-based hydrogel facilitates stem cell differentiation, extracellular matrix homeostasis and cartilage repair in male rats.
Blockade of the vaspin-AP-1 axis inhibits arthritis development.
Sustained therapeutic effects of self-assembled hyaluronic acid nanoparticles loaded with α-Ketoglutarate in various osteoarthritis stages.
Synergistic therapeutic effect of parecoxib and ilomastat combination in osteoarthritis via inhibition of IL-17/PI3K/AKT/NF-κB activity.
Piezo1 promotes intervertebral disc degeneration through the Ca(2+)/F-actin/Yap signaling axis.
Alleviation of inflammation in paraventricular nucleus and sympathetic outflow by melatonin efficiently repairs endplate porosities and attenuates spinal hyperalgesia.
circ_0000389 inhibits intervertebral disc degeneration by targeting the miR-346/KLF7 axis.
Selective promotion of sensory innervation-mediated immunoregulation for tissue repair.
Low intensity pulsed ultrasound alleviates synovial fibrosis in osteoarthritis via the PI3K/AKT pathway.
Targeting Txnip-mediated metabolic reprogramming has therapeutic potential for osteoarthritis.
Orientin alleviates chondrocyte senescence and osteoarthritis by inhibiting PI3K/AKT pathway.
LATS1-modulated ZBTB20 perturbing cartilage matrix homeostasis contributes to early-stage osteoarthritis.
A bladder-blood immune barrier constituted by suburothelial perivascular macrophages restrains uropathogen dissemination.
Gastrodin Alleviates Lumbar Intervertebral Disc Degeneration by Suppressing the NF-κB and MAPK Pathways.
Naringin in repairing articular cartilage injury by activating TGF-β/Smad signaling pathway to attenuate inflammatory response.
GM@mTG-V microspheres promote NP regeneration by reconstructing IVD biomechanics and inflammatory microenvironment.
Membrane biomimetic nanoenzyme-incorporated hybrid glycyrrhizic acid hydrogel for precise mitochondrial ROS scavenging for osteoarthritis treatment.
Vaccarin ameliorates osteoarthritis by suppressing the c-Jun N-terminal kinase (JNK)-serum amyloid A2 (SAA2) pathway mediating chondrocyte senescence.
CIP2A promotes inflammation and exacerbates osteoarthritis by targeting CEMIP.
Role and mechanism of lncRNA ZEB1-AS1 endogenous competition for miR-365a-3p targeting NRF2 in ferroptosis in articular chondrocytes.
Unveiling the mechanisms of mechanical loading-induced knee osteoarthritis through transcriptomics.
Berberine alleviates tendinopathy by suppressing the cGAS-STING pathway and Relieving ferroptosis.
Exosomal miR-574-3p from adipose-derived mesenchymal stem modulates CRIM1/BMPs signaling to restrain chondrocytes hypertrophy and inflammatory response in knee osteoarthritis.
Ginsenoside Rh1 attenuates chondrocyte senescence and osteoarthritis via AMPK/PINK1/Parkin-mediated mitophagy.
Merlin controls limb development and thumb formation by regulating primary cilium-hedgehog signaling.
RTA 408 attenuates TBHP-Induced apoptosis in nucleus pulposus cells via Nrf2/ARE and NF-κB signaling pathways: in vitro and in vivo evidence for mitigating rats' intervertebral disc degeneration.
Modulating systemic anti-inflammatory response mitigates osteoarthritis progression and associated pain after low-dose radiotherapy.
Injection of human umbilical cord mesenchymal stem cells exosomes for the treatment of knee osteoarthritis: from preclinical to clinical research.
Verification of Pain-Related Neuromodulation Mechanisms of Calcitonin in Knee Osteoarthritis.
Micro-Focused Ultrasound Technology for Remodeling of Skin Tissue Architecture in an Animal Model.
Senkyunolide I prevent chondrocytes from oxidative stress through Nrf2/HO-1 signaling pathway.
Spatiotemporally Programming Microenvironment to Recapitulate Endochondral Ossification via Greenhouse-Inspired Bionic Niche.
Crosstalk between ferroptosis and NLRP3, a possible therapeutic target in experimentally-induced rheumatoid arthritis: role of P2Y12R inhibition in modulating P53/SLC7A11/ALOX15 signaling.
Blocking the LRH-1/LCN2 axis by ML-180, an LRH-1 inverse agonist, ameliorates osteoarthritis via inhibiting the MAPK pathway.
Inhibition of Heat Shock Protein 90β by Catalpol: A Potential Therapeutic Approach for Alleviating Inflammation-Induced Cartilage Injuries in Osteoarthritis.
Liposome-encapsulated AICAR hydrogel regulates macrophage metabolic reprogramming via SIK1 activation to alleviate osteoarthritis.
CircZNF418 alleviates oxidative stress-induced cartilage endplate degeneration by stabilizing Sox9 through HuR.
Adipose Mesenchymal Stem Cells Derived Exosomes Ameliorates KOA Cartilage Damage and Inflammation by Activation of PINK1-Mediated Mitochondrial Autophagy.
Periplocin targets LRP4 to regulate metabolic homeostasis and anti-inflammation for the treatment of IVDD.
Genetically engineered chondrocyte-mimetic nanoplatform attenuates osteoarthritis by blocking IL-1β and restoring sirtuin-3.
Antler base (Cervus nippon Temminck) peptides modulate the NLRP3 inflammatory pyroptosis and Nrf2/HO-1/NQO1 signaling pathways to ameliorate osteoarthritis: a structural and mechanistic study.
Systematic pharmacology and experimental validation revealed the mechanism of Bupleurum chinense DC -mediated autophagy in alleviating osteoarthritis.
FK506 contributes to peripheral nerve regeneration by inhibiting neuroinflammatory responses and promoting neuron survival.
Defective RuO(2) Nanospheres Attenuate Osteoarthritis Progression via Suppressing the ROS/NLRP3/Caspase-1 Signaling Pathway.
MicroRNA‑4327 regulates TGF‑β1 stimulation of matrix metalloproteinase‑13 expression via CREB‑binding protein‑mediated Runx2 acetylation in human osteoblasts.
Protective role of Yougui Yin in experimental knee osteoarthritis: From the perspective of macrophage polarization.
The antiarthritic effect of CBR-470-1 in hypoxic environment is to increase the level of NOD-like receptor family pyrin domain containing 3 ubiquitination by decreasing phosphoglycerate kinase 1 activity.
Cell-free osteoarthritis treatment with dual-engineered chondrocyte-targeted extracellular vesicles derived from mechanical loading primed mesenchymal stem cells.
EZH2/miR-142-3p/HMGB1 axis mediates chondrocyte pyroptosis by regulating endoplasmic reticulum stress in knee osteoarthritis.
Characterization of a chemically induced osteoarthritis model in zebrafish.
Enhanced Chondrogenic Potential and Osteoarthritis Treatment Using Cyaonoside A-Induced MSC Delivered via a Hyaluronic Acid-Based Hydrogel System.
Integrated analysis of bioinformatics, mendelian randomization, and experimental validation reveals novel diagnostic and therapeutic targets for osteoarthritis: progesterone as a potential therapeutic agent.
Tree shrew as a new animal model for musculoskeletal disorders and aging.
Marein ameliorates the progression of osteoarthritis: An in vitro and in vivo studies.
RICTOR-mediated activation of AKT/mTOR signaling and autophagy inhibition promote osteoarthritis.
Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Loaded Mir-29-3p Targets AhR to Improve Juvenile Idiopathic Arthritis via Inhibiting the Expression of IL-22 in CD4(+) T Cell.
Blocking the CCL5/CCL7-CCR1 axis regulates macrophage polarization through NF-κB pathway to alleviate the progression of osteoarthritis.
Ferristatin II protects nucleus pulposus against degeneration through inhibiting ferroptosis and activating HIF-1α pathway mediated mitophagy.
kexB Gene Correlates With Aspergillus flavus Keratitis Severity: A Whole-Genome Analysis.
Revolutionizing the treatment of intervertebral disc degeneration: an approach based on molecular typing.
Matrix stiffness regulates nucleus pulposus cell glycolysis by MRTF-A-dependent mechanotransduction.
Yanghe decoction alleviates osteoarthritis by AMPK-SIRT3 positive feedback loop-mediated mitochondrial autophagy.
Delivery of FBXO6 with highly branched poly(β-amino ester)s to modulate the inflammatory environment for the treatment of osteoarthritis.
An Ex Vivo Model of Intervertebral Disc Degeneration for Assessing Retention of Injectable Cell-Based Grafts.
Experimental study on the role and biomarker potential of CX3CR1 in osteoarthritis.
Bioenergetic-active hydrogel drives extracellular matrix synthesis for cartilage repair.
Calcified Cartilage Zone Remodeling Induced by IL-1β Derived from Necrotic Subchondral Bone Initiates Cartilage Degeneration in Patients with Glucocorticoids-induced Osteonecrosis of the Femoral Head.
Integrating superlubricative nanomaterials with precision drug delivery for advanced osteoarthritis therapy.
Bottom-up engineering of the nucleus pulposus using a photocrosslinkable decellularized matrix hydrogel attenuates inflammaging and enhances microtissue-mediated regeneration.
Circadian rhythm disturbance induces osteoarthritis in mice: Involvement of Clock and Bmal1 dysregulation and Pdgfa inhibition.
Dysfunctional autophagy triggers STING1 activation to exacerbate cartilage degeneration in obesity-associated osteoarthritis.
HSF1 Increases EOGT-Mediated Glycosylation of Notch1 to Promote IL-1β-Induced Inflammatory Injury of Chondrocytes.
Microenvironment-Responsive Injectable Microspheres for Osteoarthritis Treatment via Oxidative Stress Inhibition and Sustained Lubrication.
TLR4-IN-C34 attenuates the progression of osteoarthritis through inhibiting inflammation, angiogenesis and pain.
Partial meniscus allograft transplantation preserving the recipient's anterior root: a comparative study in a rabbit model.
Photobiomodulation mitigates chondrocyte catabolism in osteoarthritis by modulating macrophage M1 polarization through the IL-6/JAK/STAT pathway.
Hydrogels Derived from Native Decellularized Perichondrium for Chondrocyte Differentiation and Temporomandibular Joint Repair.
RNF152-mediated, ubiquitin-dependent degradation of HSP27 activates the PI3K/AKT pathway, driving synovial inflammatory cascades in TMJOA.
Denosumab attenuates knee osteoarthritis progression by inhibiting synovial inflammation via the RANK/TRAF6/FSTL1 signalling.
Panaxatriol exerts anti-senescence effects and alleviates osteoarthritis and cartilage repair fibrosis by targeting UFL1.
WSTF nuclear autophagy regulates chronic but not acute inflammation.
Microneedle Radiofrequency Induces Extracellular Matrix Remodeling Through Fibroblast Activation: A Histological Study in a Porcine Model.
Schistosoma japonicum-Derived Peptide SJMHE1 Attenuates Osteoarthritis by Promoting Synovial M2 Macrophage Polarisation.
Pterostilbene Improves Apoptosis, Inflammation, and Autophagy of Osteoarthritis Chondrocytes Through the Ras/Raf/MEK/ERK Pathway.
Dual-functional ROS-responsive hydrogel alleviates temporomandibular joint osteoarthritis by enhancing cartilage repair and mitigating inflammation.
Deliver CEBPE via cartilage targeting Lipid nanoparticle to block CEBPE-LTF-STAT3 positive feedback loop for efficient treatment of cartilage endplate degeneration.
Zn(2+)-driven metformin conjugated with siRNA attenuates osteoarthritis progression by inhibiting NF-κB signaling and activating autophagy.
The Mechanosensitive Ion Channel Piezo1 Regulates Chondrocyte Homeostasis Through the PI3K/AKT/mTORC1 Pathway in Osteoarthritis.
Biomimetic Nanoplatform Integrating CeO₂ Nanozymes and Anti-Inflammatory Peptides for Osteoarthritis Therapy.
USP5-Rich Apoptotic Extracellular Vesicles Regulate Nucleus Pulposus Cells Apoptosis and DNA Damage Repair by Preventing E2F1 Proteasomal Degradation.
β-Mangostin Attenuates TET2-Mediated DNA Demethylation of Prkcg in the Prevention of Intervertebral Disc Degeneration.
Eosinophils-Induced Lumican Secretion by Synovial Fibroblasts Alleviates Cartilage Degradation via the TGF-β Pathway Mediated by Anxa1 Binding.
DNA Origami-Based CD44-Targeted Therapy Silences Stat3 Enhances Cartilage Regeneration and Alleviates Osteoarthritis Progression.
A sonoelectric niche for noninvasive intervertebral disc regeneration via targeted cell cycle modulation.
Matrix Stiffening-Induced SLIT3 Activation in Chondrocytes Drives Cartilage Degradation and Angiogenesis in Temporomandibular Joint Osteoarthritis.
Moxibustion ameliorates abnormal subchondral bone remodeling by promoting ACSL1-mediated autophagy to degrade NLRP3 in osteoarthritis.
Targeting MLKL ameliorates T-2 toxin-induced cartilage damage by inhibiting chondrocyte death and matrix degradation in mice.
The miR-6779/XIAP axis alleviates IL-1β-induced chondrocyte senescence and extracellular matrix loss in osteoarthritis.
Synergizing adaptive immunity and regenerative signals to enhance osteochondral defects repair.
Total glucosides of white paeony capsule alleviate articular cartilage degeneration and aberrant subchondral bone remodeling in knee osteoarthritis.
sLithospermic acid etched ZIF-8 nanoparticles delays osteoarthritis progression by inhibiting inflammatory signaling pathways and rescuing mitochondrial damage.
Cerium Dioxide Nanoparticles-Based Inspector Enhances Mitochondrial Quality Control to Maintain Chondrocyte Homeostasis in Osteoarthritis Therapy.
β-Diketone Functionalized Microspheres Chelate Reactive Iron via Metal Coordination for Cartilage Repair.
Palmatine activation of TFEB enhances autophagy and alleviates endoplasmic reticulum stress in intervertebral disc degeneration.
Regulatory effect and mechanism of CircSEC24A in IL-1β-induced osteoarthritis.
LIPUS Promotes Calcium Oscillation and Enhances Calcium Dependent Autophagy of Chondrocytes to Alleviate Osteoarthritis.
S-propargyl-cysteine attenuates temporomandibular joint osteoarthritis by regulating macrophage polarization via Inhibition of JAK/STAT signaling.
Lacc1-engineered extracellular vesicles reprogram mitochondrial metabolism to alleviate inflammation and cartilage degeneration in TMJ osteoarthritis.
Notopterol mitigates osteoarthritis progression and relieves pain in mice by inhibiting PI3K/Akt/GPX4-mediated ferroptosis.
RNA-binding protein HuR interacts with UFM1 mRNA to ameliorate chondrocyte inflammation, apoptosis and extracellular matrix degradation.
LGR6 modulates intervertebral disc degeneration through regulation of macrophage efferocytosis.
FAM20B-Catalyzed Glycosylation Regulates the Chondrogenic and Osteogenic Differentiation of the Embryonic Condyle by Controlling IHH Diffusion and Release.
LncRNA EMBP1 sponges miR-454-3p to upregulate IRF1 and activate NLRP3-mediated chondrocyte pyroptosis to drive osteoarthritis progression.
Impact of Escherichia coli and Lipopolysaccharide on the MAPK Signaling Pathway, MMPs, TIMPs, and the uPA System in Bovine Mammary Epithelial Cells.
Platelet-rich plasma ameliorates cartilage degradation in rat models of osteoarthritis via the OPG/RANKL/RANK system.
M2 Macrophage-Derived Small Extracellular Vesicles Ameliorate Pyroptosis and Intervertebral Disc Degeneration.
CD62E- and ROS-Responsive ETS Improves Cartilage Repair by Inhibiting Endothelial Cell Activation through OPA1-Mediated Mitochondrial Homeostasis.
The role and underlying mechanism of dental pulp stem cell-derived exosomal miR-31 in the treatment of osteoarthritis by targeting mTOR to enhance chondrocyte autophagy levels.
The Therapeutic Potential of Pristimerin in Osteoarthritis: Mechanistic Insights from in vitro and in vivo Studies.
Systematic Pharmacology and Experimental Validation to Reveal the Alleviation of Astragalus membranaceus Regulating Ferroptosis in Osteoarthritis.
"Dictionary of immune responses" reveals the critical role of monocytes and the core target IRF7 in intervertebral disc degeneration.
Spermidine attenuates chondrocyte inflammation and cellular pyroptosis through the AhR/NF-κB axis and the NLRP3/caspase-1/GSDMD pathway.
Identification of candidate genes and chemicals associated with osteonecrosis of femoral head by multiomics studies and chemical-gene interaction analysis.
A rabbit osteochondral defect (OCD) model for evaluation of tissue engineered implants on their biosafety and efficacy in osteochondral repair.
Melatonin Alleviates Osteoarthritis by Regulating NADPH Oxidase 4-Induced Ferroptosis and Mitigating Mitochondrial Dysfunction.
Memantine attenuates the development of osteoarthritis by blocking NMDA receptor mediated calcium overload and chondrocyte senescence.
Selenium Deficiency Can Promote the Expression of VEGF and Inflammatory Factors in Cartilage Differentiation and Mediates Cartilage Injury.
DSCR1-1 attenuates osteoarthritis-associated chondrocyte injury by regulating the CREB1/ALDH2/Wnt/β-catenin axis: An in vitro and in vivo study.
Suppression of YAP Ameliorates Cartilage Degeneration in Ankle Osteoarthritis via Modulation of the Wnt/β-Catenin Signaling Pathway.
Hypoxia-Preconditioned BMSC-Derived Exosomes Induce Mitophagy via the BNIP3-ANAX2 Axis to Alleviate Intervertebral Disc Degeneration.
Osteopontin deficiency promotes cartilaginous endplate degeneration by enhancing the NF-κB signaling to recruit macrophages and activate the NLRP3 inflammasome.
10-hydroxy-2-decenoic acid prevents osteoarthritis by targeting aspartyl β hydroxylase and inhibiting chondrocyte senescence in male mice preclinically.
Deferoxamine alleviates chondrocyte senescence and osteoarthritis progression by maintaining iron homeostasis.
Lubricin-Inspired Nanozymes Reconstruct Cartilage Lubrication System with an "In-Out" Strategy.
Ellagic acid improves osteoarthritis by inhibiting PGE2 production in M1 macrophages via targeting PTGS2.
A novel mesenchymal stem cell-targeting dual-miRNA delivery system based on aptamer-functionalized tetrahedral framework nucleic acids: Application to endogenous regeneration of articular cartilage.
LTF ameliorates cartilage endplate degeneration by suppressing calcification, senescence and matrix degradation through the JAK2/STAT3 pathway.
Therapeutic framework nucleic acid complexes targeting oxidative stress and pyroptosis for the treatment of osteoarthritis.
Multifunctional human serum albumin-crosslinked and self-assembling nanoparticles for therapy of periodontitis by anti-oxidation, anti-inflammation and osteogenesis.
Single-cell RNA sequencing reveals the MIF/ACKR3 receptor-ligand interaction between neutrophils and nucleus pulposus cells in intervertebral disc degeneration.
Collagen denaturation in post-run Achilles tendons and Achilles tendinopathy: In vivo mechanophysiology and magnetic resonance imaging.
IRF1-mediated upregulation of PARP12 promotes cartilage degradation by inhibiting PINK1/Parkin dependent mitophagy through ISG15 attenuating ubiquitylation and SUMOylation of MFN1/2.
Exploring the Mechanism of Sempervirine Inhibiting Glioblastoma Invasion Based on Network Pharmacology and Bioinformatics.
Bioenergetic-active exosomes for cartilage regeneration and homeostasis maintenance.
A RANKL-UCHL1-sCD13 negative feedback loop limits osteoclastogenesis in subchondral bone to prevent osteoarthritis progression.
TDP-43 ameliorates aging-related cartilage degradation through preventing chondrocyte senescence.
Leukemia inhibitory factor protects against experimental periodontitis through immuno-modulations of both macrophages and periodontal ligament fibroblasts.
β-Hydroxybutyrate enhances chondrocyte mitophagy and reduces cartilage degeneration in osteoarthritis via the HCAR2/AMPK/PINK1/Parkin pathway.
Circular RNA KIAA0564 Serves as a Competitive Endogenous RNA for MicroRNA-424-5p, Mediating the Expression of Lysine Demethylase 4a, Thereby Facilitating Intervertebral Disc Degeneration.
Targeted Therapy of Osteoarthritis via Intra-Articular Delivery of Lipid-Nanoparticle-Encapsulated Recombinant Human FGF18 mRNA.
Anti-Stress and Anti-ROS Effects of MnOx-Functionalized Thermosensitive Nanohydrogel Protect BMSCs for Intervertebral Disc Degeneration Repair.
Tetrahedral Framework Nucleic Acid-Based Delivery of Astaxanthin Suppresses Chondrocyte Pyroptosis and Modulates Oxidative Stress for the Treatment of Osteoarthritis.
RIP1 inhibition reduces chondrocyte apoptosis through downregulating nuclear factor-kappa B signaling in a mouse osteoarthritis model.
Development of a novel HER2-CAR monocyte cell therapy with controllable proliferation and enhanced anti-tumor efficacy.
Screening and validation of key genes associated with osteoarthritis.
Inhibition of PA28γ expression can alleviate osteoarthritis by inhibiting endoplasmic reticulum stress and promoting STAT3 phosphorylation.
Proteoglycans Enhance the Therapeutic Effect of BMSC Transplantation on Osteoarthritis.
Phillyrin: A potential therapeutic agent for osteoarthritis via modulation of NF-κB and Nrf2 signaling pathways.
Protective effects of sugarcane polyphenol against UV-B-induced photoaging in Balb/c mouse skin: Antioxidant, anti-inflammatory, and anti-glycosylation Effects.
HIF-2α/TFR1 mediated iron homeostasis disruption aggravates cartilage endplate degeneration through ferroptotic damage and mtDNA release: A new mechanism of intervertebral disc degeneration.
Histological and immunohistochemical analyses of articular cartilage during onset and progression of pre- and early-stage osteoarthritis in a rodent model.
D-mannose alleviates intervertebral disc degeneration through glutamine metabolism.
Effect of umbilical cord blood-mononuclear cells on knee osteoarthritis in rabbits.
Genkwanin alleviates intervertebral disc degeneration via regulating ITGA2/PI3K/AKT pathway and inhibiting apoptosis and senescence.
IGF2BP2 regulates the inflammation of fibroblast-like synoviocytes via GSTM5 in rheumatoid arthritis.
Machine learning-based identification and immune characterization of ferroptosis-related molecular clusters in osteoarthritis and validation.
Human Umbilical Cord Mesenchymal Stromal Cell-Derived Extracellular Vesicles Induce Fetal Wound Healing Features Revealed by Single-Cell RNA Sequencing.
Maslinic acid alleviates intervertebral disc degeneration by inhibiting the PI3K/AKT and NF-κB signaling pathways.
Matrix stiffening promotes chondrocyte senescence and the osteoarthritis development through downregulating HDAC3.
An integrated network pharmacology, molecular docking and experiment validation study to investigate the potential mechanism of Isobavachalcone in the treatment of osteoarthritis.
Spinosin ameliorates osteoarthritis through enhancing the Nrf2/HO-1 signaling pathway.
siRNA incorporated in slow-release injectable hydrogel continuously silences DDIT4 and regulates nucleus pulposus cell pyroptosis through the ROS/TXNIP/NLRP3 axis to alleviate intervertebral disc degeneration.
Ginkgolide C inhibits ROS-mediated activation of NLRP3 inflammasome in chondrocytes to ameliorate osteoarthritis.
Hnrnpk protects against osteoarthritis through targeting WWC1 mRNA and inhibiting Hippo signaling pathway.
Engineered Exosomes with ATF5-Modified mRNA Loaded in Injectable Thermogels Alleviate Osteoarthritis by Targeting the Mitochondrial Unfolded Protein Response.
Circ_ST6GAL1-mediated competing endogenous RNA network regulates TGF-β1-stimulated matrix Metalloproteinase-13 expression via Runx2 acetylation in osteoblasts.
Dynamics of N6-methyladenosine modification during aging and their potential roles in the degeneration of intervertebral disc.
Involvement of DJ-1 in the pathogenesis of intervertebral disc degeneration via hexokinase 2-mediated mitophagy.
RPL35 downregulated by mechanical overloading promotes chondrocyte senescence and osteoarthritis development via Hedgehog-Gli1 signaling.
Mitochondrial-targeting and NIR-responsive Mn(3)O(4)@PDA@Pd-SS31 nanozymes reduce oxidative stress and reverse mitochondrial dysfunction to alleviate osteoarthritis.
Inhibition of SAT1 alleviates chondrocyte inflammation and ferroptosis by repressing ALOX15 expression and activating the Nrf2 pathway.
CircEYA3 aggravates intervertebral disc degeneration through the miR-196a-5p/EBF1 axis and NF-κB signaling.
Gentiopicroside ameliorates the lipopolysaccharide-induced inflammatory response and hypertrophy in chondrocytes.
Circular RNA CircFOXO3 Functions as a Competitive Endogenous RNA for Acid-Sensing Ion Channel Subunit 1 Mediating Oxeiptosis in Nucleus Pulposus.
TfR1 mediated iron metabolism dysfunction as a potential therapeutic target for osteoarthritis.
Low-intensity pulsed ultrasound delays the progression of osteoarthritis by regulating the YAP-RIPK1-NF-κB axis and influencing autophagy.
Oxymatrine protects articular chondrocytes from IL-1β-induced damage through autophagy activation via AKT/mTOR signaling pathway inhibition.
Kongensin a attenuates intervertebral disc degeneration by inhibiting TAK1-mediated PANoptosis of nucleus pulposus cells.
Atractylenolide-III attenuates osteoarthritis by repolarizing macrophages through inactivating TLR4/NF-κB signaling.
Moderate mechanical stress suppresses chondrocyte ferroptosis in osteoarthritis by regulating NF-κB p65/GPX4 signaling pathway.
Apigetrin alleviates intervertebral disk degeneration by regulating nucleus pulposus cell autophagy.
A natural hydrogel complex improves intervertebral disc degeneration by correcting fatty acid metabolism and inhibiting nucleus pulposus cell pyroptosis.
A multifunctional nanogel encapsulating layered double hydroxide for enhanced osteoarthritis treatment via protection of chondrocytes and ECM.
Platelet-rich plasma alleviates knee arthritis in rats by inhibiting p65.
Injectable Ozone-Rich Nanocomposite Hydrogel Loaded with D-Mannose for Anti-Inflammatory and Cartilage Protection in Osteoarthritis Treatment.
Botulinum toxin A attenuates osteoarthritis development via inhibiting chondrocyte ferroptosis through SLC7Al1/GPX4 axis.
IL16 Regulates Osteoarthritis Progression as a Target Gene of Novel-miR-81.
Development of primary osteoarthritis during aging in genetically diverse UM-HET3 mice.
A Novel Role for Protein Tyrosine Phosphatase 1B in Alleviating Chondrocyte Senescence.
Identification of osteoblastic autophagy-related genes for predicting diagnostic markers in osteoarthritis.
S100A6 Regulates nucleus pulposus cell apoptosis via Wnt/β-catenin signaling pathway: an in vitro and in vivo study.
Time-Dependent Effect of Eggshell Membrane on Monosodium-Iodoacetate-Induced Osteoarthritis: Early-Stage Inflammation Control and Late-Stage Cartilage Protection.
Targeting the senescence-related genes MAPK12 and FOS to alleviate osteoarthritis.
TBK1 pharmacological inhibition mitigates osteoarthritis through attenuating inflammation and cellular senescence in chondrocytes.
Scutellarein alleviates osteoarthritis progression through the PI3K/Akt/NF-kappaB signaling pathway: In vitro and in vivo studies.
Microenvironment-responsive metal-phenolic network release platform with ROS scavenging, anti-pyroptosis, and ECM regeneration for intervertebral disc degeneration.
MMP13-targeted siRNA-loaded micelles for diagnosis and treatment of posttraumatic osteoarthritis.
GPX7 reduces chondrocyte inflammation and extracellular matrix degradation triggered by IL‑1β, via a mechanism mediated by ferroptosis.
Acetyl-11-keto-β-boswellic acid restrains the progression of synovitis in osteoarthritis via the Nrf2/HO-1 pathway.
Quercetin Modulates Ferroptosis via the SIRT1/Nrf-2/HO-1 Pathway and Attenuates Cartilage Destruction in an Osteoarthritis Rat Model.
Pain Relief, Functional Recovery, and Chondroprotective Effects of Angelica gigas Nakai in Osteoarthritis Due to Its Anti-Inflammatory Property: An In Vitro and In Vivo Study.
Fabrication of heterocellular spheroids with controllable core-shell structure using inertial focusing effect for scaffold-free 3D cell culture models.
IRF1 regulation of ZBP1 links mitochondrial DNA and chondrocyte damage in osteoarthritis.
Circadian rhythm disruption upregulating Per1 in mandibular condylar chondrocytes mediating temporomandibular joint osteoarthritis via GSK3β/β-CATENIN pathway.
Rescue of nucleus pulposus cells from an oxidative stress microenvironment via glutathione-derived carbon dots to alleviate intervertebral disc degeneration.
The Combined Intraosseous Administration of Orthobiologics Outperformed Isolated Intra-articular Injections in Alleviating Pain and Cartilage Degeneration in a Rat Model of MIA-Induced Knee Osteoarthritis.
TCF12 regulates the TGF-β/Smad2/3 signaling pathway to accelerate the progression of osteoarthritis by targeting CXCR4.
microRNA-365 attenuated intervertebral disc degeneration through modulating nucleus pulposus cell apoptosis and extracellular matrix degradation by targeting EFNA3.
CircIRAK3 exerts negative feedback regulation on inflammation by binding to HNRNP U and destabilizing proinflammatory cytokine mRNA in osteoarthritis and chondrogenesis.
Moxibustion ameliorates osteoarthritis by regulating gut microbiota via impacting cAMP-related signaling pathway.
Gut-joint axis: Oral Probiotic ameliorates Osteoarthritis.
Ganoderic acid A slows osteoarthritis progression by attenuating endoplasmic reticulum stress and blocking NF-Κb pathway.
Exercise-induced modulation of myokine irisin on muscle-bone unit in the rat model of post-traumatic osteoarthritis.
Danggui-Shaoyao-San (DSS) ameliorates the progression of osteoarthritis via suppressing the NF-κB signaling pathway: an in vitro and in vivo study combined with bioinformatics analysis.
Carveol alleviates osteoarthritis progression by acting on synovial macrophage polarization transformation: An in vitro and in vivo study.
Sesamin-mediated high expression of BECN2 ameliorates cartilage endplate degeneration by reducing autophagy and inflammation.
The protective effect of Ergolide in osteoarthritis: In vitro and in vivo studies.
Single-cell atlas of human infrapatellar fat pad and synovium implicates APOE signaling in osteoarthritis pathology.
Selenium-SelK-GPX4 axis protects nucleus pulposus cells against mechanical overloading-induced ferroptosis and attenuates senescence of intervertebral disc.
Development of primary osteoarthritis during aging in genetically diverse UM-HET3 mice.
The CREB1 inhibitor 666-15 maintains cartilage homeostasis and mitigates osteoarthritis progression.
Development of primary osteoarthritis during aging in genetically diverse UM-HET3 mice.
General Control Non-derepressible 2 Alleviates Cartilage Degeneration and Inhibits NLRP3 Inflammasome Activation in Osteoarthritis.
Nrf2 protects against cartilage endplate degeneration through inhibiting NCOA4‑mediated ferritinophagy.
The sonic hedgehog pathway suppresses oxidative stress and senescence in nucleus pulposus cells to alleviate intervertebral disc degeneration via GPX4.
Network Pharmacology and Experimental Verifications to Discover Scutellaria baicalensis Georgi's Effects on Joint Inflammation, Destruction, and Pain in Osteoarthritis.
Loss of Slc39a12 in hippocampal neurons is responsible for anxiety-like behavior caused by temporomandibular joint osteoarthritis.
Fisetin suppresses chondrocyte senescence and attenuates osteoarthritis progression by targeting sirtuin 6.
P21 resists ferroptosis in osteoarthritic chondrocytes by regulating GPX4 protein stability.
Inhibition of HOXD11 promotes cartilage degradation and induces osteoarthritis development.
Analysis and identification of ferroptosis-related diagnostic markers in rheumatoid arthritis.
Novel injectable adhesive hydrogel loaded with exosomes for holistic repair of hemophilic articular cartilage defect.
Esculin Alleviates Osteoarthritis Progression Through the Sirt1/NF-κB Pathway.
An injectable self-lubricating supramolecular polymer hydrogel loaded with platelet lysate to boost osteoarthritis treatment.
Enhanced therapeutic potential of a self-healing hyaluronic acid hydrogel for early intervention in osteoarthritis.
MSCs-derived ECM functionalized hydrogel regulates macrophage reprogramming for osteoarthritis treatment by improving mitochondrial function and energy metabolism.
The active ingredient of Evodia rutaecarpa reduces inflammation in knee osteoarthritis rats through blocking calcium influx and NF-κB pathway.
Lycopodium japonicum Thunb. inhibits chondrocyte apoptosis, senescence and inflammation in osteoarthritis through STING/NF-κB signaling pathway.
A human organoid drug screen identifies α2-adrenergic receptor signaling as a therapeutic target for cartilage regeneration.
Ginkgolide A enhances FoxO1 expression and reduces endoplasmic reticulum stress to mitigate osteoarthritis in mice.
Kongensin A targeting PI3K attenuates inflammation-induced osteoarthritis by modulating macrophage polarization and alleviating inflammatory signaling.
High-Intensity Interval Training Increases Osteoarthritis-Associated Pain-Sensitive Threshold Through Reduction of Perineuronal Nets of the Medial Prefrontal Cortex in Rats.
Guilu Erxian glue reduces endoplasmic reticulum stress-mediated apoptosis and restores the balance of extracellular matrix synthesis and degradation in chondrocytes by inhibiting the ATF6/GRP78/CHOP signaling pathway.
Identification and validation of up-regulated TNFAIP6 in osteoarthritis with type 2 diabetes mellitus.
T-2 toxin induces chondrocyte extracellular matrix degradation by regulating the METTL3-mediated Ctsk m6A modification.
Wedelolactone alleviates inflammation and cartilage degeneration by suppressing the NF-κB signaling pathway in osteoarthritis.
Targeted lipid nanoparticles distributed in hydrogel treat osteoarthritis by modulating cholesterol metabolism and promoting endogenous cartilage regeneration.
Celecoxib Combined with Tocilizumab Has Anti-Inflammatory Effects and Promotes the Recovery of Damaged Cartilage via the Nrf2/HO-1 Pathway In Vitro.
Potential Effects of Indomethacin on Alleviating Osteoarthritis Progression in Vitro.
Nrf2 activation by pyrroloquinoline quinone inhibits natural aging-related intervertebral disk degeneration in mice.
Excessive mechanical loading promotes osteoarthritis development by upregulating Rcn2.
Zwitterion-Lubricated Hydrogel Microspheres Encapsulated with Metformin Ameliorate Age-Associated Osteoarthritis.
Mulberroside A mitigates intervertebral disc degeneration by inhibiting MAPK and modulating Ppar-γ/NF-κB pathways.
4-Octyl itaconate protects chondrocytes against IL-1β-induced oxidative stress and ferroptosis by inhibiting GPX4 methylation in osteoarthritis.
Oxygen vacancy-engineered cerium oxide mediated by copper-platinum exhibit enhanced SOD/CAT-mimicking activities to regulate the microenvironment for osteoarthritis therapy.
Matrix stiffness aggravates osteoarthritis progression through H3K27me3 demethylation induced by mitochondrial damage.
METTL3 Promotes Nucleus Pulposus Cell Senescence in Intervertebral Disc Degeneration by Regulating TLR2 m6A Methylation and Gut Microbiota.
Inhibiting DNA methyltransferase DNMT3B confers protection against ferroptosis in nucleus pulposus and ameliorates intervertebral disc degeneration via upregulating SLC40A1.
Scutellarein Ameliorated Chondrocyte Inflammation and Osteoarthritis in Rats.
Baicalin Maintains Articular Cartilage Homeostasis and Alleviates Osteoarthritis by Activating FOXO1.
Spermidine ameliorates osteoarthritis via altering macrophage polarization.
Inflammatory Fibroblast-Like Synoviocyte-Derived Exosomes Aggravate Osteoarthritis via Enhancing Macrophage Glycolysis.
Gold nanoparticles exhibit anti-osteoarthritic effects via modulating interaction of the "microbiota-gut-joint" axis.
Confirmation of pain-related neuromodulation mechanism of Bushen Zhuangjin Decoction on knee osteoarthritis.
AP39 through AMPK-ULK1-FUNDC1 pathway regulates mitophagy, inhibits pyroptosis, and improves doxorubicin-induced myocardial fibrosis.
Verapamil Attenuates the Severity of Tendinopathy by Mitigating Mitochondrial Dysfunction through the Activation of the Nrf2/HO-1 Pathway.
Biomimetic zwitterionic copolymerized chitosan as an articular lubricant.
pH-Responsive Delivery of H2 through Ammonia Borane-Loaded Hollow Polydopamine for Intervertebral Disc Degeneration Therapy.
The Role of the miR-548au-3p/CA12 Axis in Tracheal Chondrogenesis in Congenital Pulmonary Airway Malformations.
Betulinic Acid Attenuates Osteoarthritis via Limiting NLRP3 Inflammasome Activation to Decrease Interleukin-1β Maturation and Secretion.
1,25-Dihydroxyvitamin D Deficiency Accelerates Aging-related Osteoarthritis via Downregulation of Sirt1 in Mice.
Pioglitazone-Loaded Cartilage-Targeted Nanomicelles (Pio@C-HA-DOs) for Osteoarthritis Treatment.
The Protective Effect of Selenium Nanoparticles in Osteoarthritis: In vitro and in vivo Studies.
Therapeutic Effect of Acupotomy at Sanheyang for Cartilage Collagen Damage in Moderate Knee Osteoarthritis: A Rabbit Model.
Digoxin protects against intervertebral disc degeneration via TNF/NF-κB and LRP4 signaling.
Identification of EGFR as an essential regulator in chondrocytes ferroptosis of osteoarthritis using bioinformatics, in vivo, and in vitro study.
Donor-Matched Peripheral Blood-Derived Mesenchymal Stem Cells Combined With Platelet-Rich Plasma Synergistically Ameliorate Surgery-Induced Osteoarthritis in Rabbits: An In Vitro and In Vivo Study.
Notopterol alleviates the progression of osteoarthritis: An in vitro and in vivo study.
Cynarin alleviates intervertebral disc degeneration via protecting nucleus pulposus cells from ferroptosis.
Engineering exosomes derived from subcutaneous fat MSCs specially promote cartilage repair as miR-199a-3p delivery vehicles in Osteoarthritis.
Genistein Suppresses IL-6 and MMP-13 to Attenuate Osteoarthritis in Obese Diabetic Mice.
Rutaecarpine ameliorates osteoarthritis by inhibiting PI3K/AKT/NF‑κB and MAPK signalling transduction through integrin αVβ3.
An in vitro and in vivo study: Valencene protects cartilage and alleviates the progression of osteoarthritis by anti-oxidative stress and anti-inflammatory effects.
Ganoderma lucidum polysaccharide peptide (GLPP) attenuates rheumatic arthritis in rats through inactivating NF-κB and MAPK signaling pathways.
Systemic pharmacology reveal the mechanism by which the Qiangjin Zhuanggu Qufeng mixture inhibits LPS-induced pyroptosis of rat nucleus pulposus cells.
Clock gene Per1 regulates rat temporomandibular osteoarthritis through NF-κB pathway: an in vitro and in vivo study.
Low-intensity pulsed ultrasound irradiation attenuates collagen degradation of articular cartilage in early osteoarthritis-like model mice.
ALKBH5-mediated m(6)A demethylation of HS3ST3B1-IT1 prevents osteoarthritis progression.
Focused low-intensity pulsed ultrasound alleviates osteoarthritis via restoring impaired FUNDC1-mediated mitophagy.
Repair of osteochondral defects: efficacy of a tissue-engineered hybrid implant containing both human MSC and human iPSC-cartilaginous particles.
Pentraxin 3 deficiency ameliorates the severity of osteoarthritis and alleviates inflammation.
Dapagliflozin suppress endoplasmic reticulum stress mediated apoptosis of chondrocytes by activating Sirt1.
α-Ketoglutaric acid ameliorates intervertebral disk degeneration by blocking the IL-6/JAK2/STAT3 pathway.
Xanthohumol alleviates palmitate-induced inflammation and prevents osteoarthritis progression by attenuating mitochondria dysfunction/NLRP3 inflammasome axis.
Orientin inhibits inflammation in chondrocytes and attenuates osteoarthritis through Nrf2/NF-κB and SIRT6/NF-κB pathway.
Pacenta polypeptide injection alleviates the fibrosis and inflammation in cigarette smoke extracts-induced BEAS-2B cells by modulating MMP-9/TIMP-1 signaling.
Acetyl zingerone ameliorates osteoarthritis by inhibiting chondrocyte programmed cell death.
Epigenetic PPARγ preservation attenuates temporomandibular joint osteoarthritis.
Pyroptosis of chondrocytes activated by synovial inflammation accelerates TMJ osteoarthritis cartilage degeneration via ROS/NLRP3 signaling.
Rspo2 exacerbates rheumatoid arthritis by targeting aggressive phenotype of fibroblast-like synoviocytes and disrupting chondrocyte homeostasis via Wnt/β-catenin pathway.
Resatorvid alleviates experimental inflammatory TMJOA by restraining chondrocyte pyroptosis and synovial inflammation.
Effect of intra-articular injection of a hyaluronic acid-alendronate conjugate on post-traumatic osteoarthritis induced by destabilization of the medial meniscus in rats.
Activation of the Nrf-2 pathway by pinocembrin safeguards vertebral endplate chondrocytes against apoptosis and degeneration caused by oxidative stress.
Oleanolic acid, a small-molecule natural product, inhibits ECM degeneration in osteoarthritis by regulating the Hippo/YAP and Wnt/β-catenin pathways.
Docosahexaenoic acid alleviates the excessive degradation of extracellular matrix in the nucleus pulposus by reducing the content of lncRNA NEAT1 to prevent the progression of intervertebral disc degeneration.
Sirt1 protects against intervertebral disc degeneration induced by 1,25-dihydroxyvitamin D insufficiency in mice by inhibiting the NF-κB inflammatory pathway.
Gli1 depletion induces oxidative stress and apoptosis of nucleus pulposus cells via Fos in intervertebral disc degeneration.
Circular RNA SLTM as a miR-421-competing endogenous RNA to mediate HMGB2 expression stimulates apoptosis and inflammation in arthritic chondrocytes.
Bone mesenchymal stem cell-derived exosomes involved co-delivery and synergism effect with icariin via mussel-inspired multifunctional hydrogel for cartilage protection.
The Bcr-Abl inhibitor DCC-2036 inhibits necroptosis and ameliorates osteoarthritis by targeting RIPK1 and RIPK3 kinases.
Down-regulated GAS6 impairs synovial macrophage efferocytosis and promotes obesity-associated osteoarthritis.
An injectable liposome-anchored teriparatide incorporated gallic acid-grafted gelatin hydrogel for osteoarthritis treatment.
Accelerated aging in articular cartilage by ZMPSTE24 deficiency leads to osteoarthritis with impaired metabolic signaling and epigenetic regulation.
Polydopamine-Pd nanozymes as potent ROS scavengers in combination with near-infrared irradiation for osteoarthritis treatment.
Preparation of Melatonin-Loaded Nanoparticles with Targeting and Sustained Release Function and Their Application in Osteoarthritis.
Physalin A alleviates intervertebral disc degeneration via anti-inflammatory and anti-fibrotic effects.
hASCs-derived exosomal miR-155-5p targeting TGFβR2 promotes autophagy and reduces pyroptosis to alleviate intervertebral disc degeneration.
METTL3 promotes SMSCs chondrogenic differentiation by targeting the MMP3, MMP13, and GATA3.
The Effect of Gut Microbiota on the Progression of Intervertebral Disc Degeneration.
Hepatic TREM2(+) macrophages express matrix metalloproteinases to control fibrotic scar formation.
Apigenin Inhibits the Progression of Osteoarthritis by Mediating Macrophage Polarization.
PTEN inhibitor VO-OHpic protects endplate chondrocytes against apoptosis and calcification via activating Nrf-2 signaling pathway.
Pan-cancer analysis reveals the associations between MMP13 high expression and carcinogenesis and its value as a serum diagnostic marker.
Therapeutic effects of kefir peptides on adjuvant-induced arthritis in rats through anti-inflammation and downregulation of matrix metalloproteinases.
Thermosensitive hydrogel for cartilage regeneration via synergistic delivery of SDF-1α like polypeptides and kartogenin.
ROS-responsive magnesium-containing microspheres for antioxidative treatment of intervertebral disc degeneration.
BACH1 promotes intervertebral disc degeneration by regulating HMOX1/GPX4 to mediate oxidative stress, ferroptosis, and lipid metabolism in nucleus pulposus cells.
Luteolin ameliorates cornea stromal collagen degradation and inflammatory damage in rats with corneal alkali burn.
Excess Growth Hormone Triggers Inflammation-Associated Arthropathy, Subchondral Bone Loss, and Arthralgia.
Stevioside protects primary articular chondrocytes against IL-1β-induced inflammation and catabolism by targeting integrin.
Astaxanthin suppresses oxidative stress and calcification in vertebral cartilage endplate via activating Nrf-2/HO-1 signaling pathway.
Isobavachalcone ameliorates the progression of osteoarthritis by suppressing NF-κB signaling pathway.
ADSCs increase the autophagy of chondrocytes through decreasing miR-7-5p in Osteoarthritis rats by targeting ATG4A.
Suramin ameliorates osteoarthritis by acting on the Nrf2/HO-1 and NF-κB signaling pathways in chondrocytes and promoting M2 polarization in macrophages.
SIRT5-related desuccinylation modification of AIFM1 protects against compression-induced intervertebral disc degeneration by regulating mitochondrial homeostasis.
Novel insights into the effect of deer IGF-1 on chondrocyte viability and IL-1β-induced inflammation response.
miR-140-5p protects cartilage progenitor/stem cells from fate changes in knee osteoarthritis.
Methyl gallate prevents oxidative stress induced apoptosis and ECM degradation in chondrocytes via restoring Sirt3 mediated autophagy and ameliorates osteoarthritis progression.
Transglutaminase 2 inhibitors attenuate osteoarthritic degeneration of TMJ-osteoarthritis by suppressing NF-κB activation.
Knockdown of LINC01138 protects human chondrocytes against IL-1β-induced damage by regulating the hsa-miR-1207-5p/KIAA0101 axis.
N-acetylglucosamine-bearing polymers mimicking O-GlcNAc-modified proteins elicit anti-fibrotic activities in myofibroblasts and activated stellate cells.
Indole-3-propionic acid alleviates chondrocytes inflammation and osteoarthritis via the AhR/NF-κB axis.
LncRNA WDR11-AS1 Promotes Extracellular Matrix Synthesis in Osteoarthritis by Directly Interacting with RNA-Binding Protein PABPC1 to Stabilize SOX9 Expression.
Ginsenoside Compound K Ameliorates Osteoarthritis by Inhibiting the Chondrocyte Endoplasmic Reticulum Stress-Mediated IRE1α-TXNIP-NLRP3 Axis and Pyroptosis.
Dendrobine Alleviates Cellular Senescence and Osteoarthritis via the ROS/NF-κB Axis.
Inhibition of Klf10 Attenuates Oxidative Stress-Induced Senescence of Chondrocytes via Modulating Mitophagy.
Targeting TRMT5 suppresses hepatocellular carcinoma progression via inhibiting the HIF-1α pathways.
Type 1 diabetes mellitus leads to gingivitis and an early compensatory increase in bone remodeling.
Hypoxia-Inducible Factor-1α Protects Against Intervertebral Disc Degeneration Through Antagonizing Mitochondrial Oxidative Stress.
Cyasterone inhibits IL-1β-mediated apoptosis and inflammation via the NF-κB and MAPK signaling pathways in rat chondrocytes and ameliorates osteoarthritisin vivo.
Platelet-derived extracellular vesicles ameliorate intervertebral disc degeneration by alleviating mitochondrial dysfunction.
Analyses of Transcriptomics upon IL-1β-Stimulated Mouse Chondrocytes and the Protective Effect of Catalpol through the NOD2/NF-κB/MAPK Signaling Pathway.
Mulberroside A alleviates osteoarthritis via restoring impaired autophagy and suppressing MAPK/NF-κB/PI3K-AKT-mTOR signaling pathways.
Matrix Stiffness Activating YAP/TEAD1-Cyclin B1 in Nucleus Pulposus Cells Promotes Intervertebral Disc Degeneration.
Treadmill Exercise Suppresses Histological Progression of Disuse Atrophy in Articular Cartilage in Rat Knee Joints during Hindlimb Suspension.
FUNDC1/PFKP-mediated mitophagy induced by KD025 ameliorates cartilage degeneration in osteoarthritis.
MiR-146b-5p enriched bioinspired exosomes derived from fucoidan-directed induction mesenchymal stem cells protect chondrocytes in osteoarthritis by targeting TRAF6.
MiR-203a-3p attenuates apoptosis and pyroptosis of chondrocytes by regulating the MYD88/NF-κB pathway to alleviate osteoarthritis progression.
Hsa_circ_0001946 Ameliorates Mechanical Stress-induced Intervertebral Disk Degeneration Via Targeting miR-432-5p and SOX9.
Bauhinia championii alleviates extracellular matrix degradation in IL-1β induced chondrocytes via miRNA-145-5p/TLR4/NF-κB axis.
Ginsenoside compound K alleviates osteoarthritis by inhibiting NLRP3‑mediated pyroptosis.
YY1/miR-140-5p/Jagged1/Notch axis mediates cartilage progenitor/stem cells fate reprogramming in knee osteoarthritis.
ROR1/STAT3 positive feedback loop facilitates cartilage degeneration in Osteoarthritis through activation of NF-κB signaling pathway.
Induced skin aging by blue-light irradiation in human skin fibroblasts via TGF-β, JNK and EGFR pathways.
Adseverin, an actin-binding protein, modulates hypertrophic chondrocyte differentiation and osteoarthritis progression.
ADRM1/RPN13 attenuates cartilage extracellular matrix degradation via enhancing UCH37-mediated ALK5 deubiquitination.
Injectable photocrosslinking spherical hydrogel-encapsulated targeting peptide-modified engineered exosomes for osteoarthritis therapy.
Skin Extracellular Matrix Breakdown Following Paclitaxel Therapy in Patients with Chemotherapy-Induced Peripheral Neuropathy.
WITHDRAWN: Expression of Tmem41b and MMP13 associated with poor outcome in osteosarcomas.
Hederagenin Suppresses Inflammation and Cartilage Degradation to Ameliorate the Progression of Osteoarthritis: An In vivo and In vitro Study.
Intra-articular treatment of temporomandibular joint osteoarthritis by injecting actively-loaded meloxicam liposomes with dual-functions of anti-inflammation and lubrication.
Cardamonin alleviates chondrocytes inflammation and cartilage degradation of osteoarthritis by inhibiting ferroptosis via p53 pathway.
Integrated Cascade Nanozyme Remodels Chondrocyte Inflammatory Microenvironment in Temporomandibular Joint Osteoarthritis via Inhibiting ROS-NF-κB and MAPK Pathways.
Dihydrocaffeic acid improves IL-1β-induced inflammation and cartilage degradation via inhibiting NF-κB and MAPK signalling pathways.
Maintaining hypoxia environment of subchondral bone alleviates osteoarthritis progression.
Monotropein attenuates apoptosis and pyroptosis in chondrocytes and alleviates osteoarthritis progression in mice.
Dioscin alleviates the progression of osteoarthritis: an in vitro and in vivo study.
Natural product, bilobalide, improves joint health in rabbits with osteoarthritis by anti-matrix degradation and antioxidant activities.
Gastrocnemius Muscle Injury Is the Condition to Induce Cartilage Degeneration of the Rabbit Tibiofemoral Joint: A New Perspective.
Selenium Attenuates TBHP-Induced Apoptosis of Nucleus Pulposus Cells by Suppressing Mitochondrial Fission through Activating Nuclear Factor Erythroid 2-Related Factor 2.
Cyclic Polypeptide D7 Protects Bone Marrow Mesenchymal Cells and Promotes Chondrogenesis during Osteonecrosis of the Femoral Head via Growth Differentiation Factor 15-Mediated Redox Signaling.
Theaflavin-3,3'-Digallate Protects Cartilage from Degradation by Modulating Inflammation and Antioxidant Pathways.
Oxymatrine Protects Chondrocytes against IL-1β-triggered Apoptosis in Vitro and Inhibits Osteoarthritis in Mice Model.
Corynoline Alleviates Osteoarthritis Development via the Nrf2/NF-κB Pathway.
Silencing of Angiopoietin-Like Protein 4 (Angptl4) Decreases Inflammation, Extracellular Matrix Degradation, and Apoptosis in Osteoarthritis via the Sirtuin 1/NF-κB Pathway.
Spheroid Formation Enhances the Regenerative Capacity of Nucleus Pulposus Cells via Regulating N-CDH and ITGβ1 Interaction.
Corosolic Acid Protects Rat Chondrocytes Against IL-1β-Induced ECM Degradation by Activating Autophagy via PI3K/AKT/mTOR Pathway and Ameliorates Rat Osteoarthritis.
3,3'-diindolylmethane inhibits LPS-induced human chondrocytes apoptosis and extracellular matrix degradation by activating PI3K-Akt-mTOR-mediated autophagy.
NRF2-directed PRPS1 upregulation to promote the progression and metastasis of melanoma.
Omaveloxolone inhibits IL-1β-induced chondrocyte apoptosis through the Nrf2/ARE and NF-κB signalling pathways in vitro and attenuates osteoarthritis in vivo.
Icariin protects vertebral endplate chondrocytes against apoptosis and degeneration via activating Nrf-2/HO-1 pathway.
The Protective Effect of Evodiamine in Osteoarthritis: An In Vitro and In Vivo Study in Mice Model.
Cepharanthine Ameliorates Chondrocytic Inflammation and Osteoarthritis via Regulating the MAPK/NF-κB-Autophagy Pathway.
Saikosaponin D Inhibited IL-1β Induced ATDC 5 Chondrocytes Apoptosis In Vitro and Delayed Articular Cartilage Degeneration in OA Model Mice In Vivo.
Deferoxamine Alleviates Osteoarthritis by Inhibiting Chondrocyte Ferroptosis and Activating the Nrf2 Pathway.
Oroxin B alleviates osteoarthritis through anti-inflammation and inhibition of PI3K/AKT/mTOR signaling pathway and enhancement of autophagy.
XMU-MP-1 attenuates osteoarthritis via inhibiting cartilage degradation and chondrocyte apoptosis.
Enhancing autophagy and energy metabolism in the meniscus can delay the occurrence of PTOA in ACLT rat.
Flavokawain A alleviates the progression of mouse osteoarthritis: An in vitro and in vivo study.
Hyaluronic acid ameliorates intervertebral disc degeneration via promoting mitophagy activation.
Transcriptomic analysis supports collective endometrial cell migration in the pathogenesis of adenomyosis.
CD40/TRAF1 decreases synovial cell apoptosis in patients with rheumatoid arthritis through JNK/NF-κB pathway.
Iron overload promotes intervertebral disc degeneration via inducing oxidative stress and ferroptosis in endplate chondrocytes.
Nanosilicate-Reinforced Silk Fibroin Hydrogel for Endogenous Regeneration of Both Cartilage and Subchondral Bone.
Magnoflorine attenuates inflammatory responses in RA by regulating the PI3K/Akt/NF-κB and Keap1-Nrf2/HO-1 signalling pathways in vivo and in vitro.
Omentin-1 promoted proliferation and ameliorated inflammation, apoptosis, and degeneration in human nucleus pulposus cells.
Vasorin-containing small extracellular vesicles retard intervertebral disc degeneration utilizing an injectable thermoresponsive delivery system.
ALPK1 Accelerates the Pathogenesis of Osteoarthritis by Activating NLRP3 Signaling.
Chicoric acid attenuates tumor necrosis factor-α-induced inflammation and apoptosis via the Nrf2/HO-1, PI3K/AKT and NF-κB signaling pathways in C28/I2 cells and ameliorates the progression of osteoarthritis in a rat model.
Self-amplifying loop of NF-κB and periostin initiated by PIEZO1 accelerates mechano-induced senescence of nucleus pulposus cells and intervertebral disc degeneration.
Calycosin mitigates chondrocyte inflammation and apoptosis by inhibiting the PI3K/AKT and NF-κB pathways.
Runx2 and Runx3 differentially regulate articular chondrocytes during surgically induced osteoarthritis development.
Astaxanthin attenuates osteoarthritis progression via inhibiting ferroptosis and regulating mitochondrial function in chondrocytes.
Dual-dynamic-bond cross-linked injectable hydrogel of multifunction for intervertebral disc degeneration therapy.
Caffeic acid phenethyl ester attenuates osteoarthritis progression by activating NRF2/HO‑1 and inhibiting the NF‑κB signaling pathway.
Selenium-sensitive histone deacetylase 2 is required for forkhead box O3A and regulates extracellular matrix metabolism in cartilage.
LncRNA TM1-3P Regulates Proliferation, Apoptosis and Inflammation of Fibroblasts in Osteoarthritis through miR-144-3p/ONECUT2 Axis.
ALPK1 Aggravates TMJOA Cartilage Degradation via NF-κB and ERK1/2 Signaling.
Carbon dots derived from folic acid attenuates osteoarthritis by protecting chondrocytes through NF-κB/MAPK pathway and reprogramming macrophages.
Gaseous signal molecule SO(2) regulates autophagy through PI3K/AKT pathway inhibits cardiomyocyte apoptosis and improves myocardial fibrosis in rats with type II diabetes.
Piceatannol suppresses inflammation and promotes apoptosis in rheumatoid arthritis‑fibroblast‑like synoviocytes by inhibiting the NF‑κB and MAPK signaling pathways.
Intra-articular injection of a novel Wnt pathway inhibitor, SM04690, upregulates Wnt16 expression and reduces disease progression in temporomandibular joint osteoarthritis.
Dual functions of microRNA-17 in maintaining cartilage homeostasis and protection against osteoarthritis.
Asporin regulated by miR-26b-5p mediates chondrocyte senescence and exacerbates osteoarthritis progression via TGF-β1/Smad2 pathway.
TGF-β1 regulates chondrocyte proliferation and extracellular matrix synthesis via circPhf21a-Vegfa axis in osteoarthritis.
The lncRNA PILA promotes NF-κB signaling in osteoarthritis by stimulating the activity of the protein arginine methyltransferase PRMT1.
Exosomes-derived miR-125-5p from cartilage endplate stem cells regulates autophagy and ECM metabolism in nucleus pulposus by targeting SUV38H1.
Paeoniflorin inhibits pyroptosis of nucleus pulposus cells in an acidic environment and alleviates the degeneration of the intervertebral disc in rats.
HSP70 attenuates compression-induced apoptosis of nucleus pulposus cells by suppressing mitochondrial fission via upregulating the expression of SIRT3.
Oxidative stress-induced circKIF18A downregulation impairs MCM7-mediated anti-senescence in intervertebral disc degeneration.
Regulation of osteoarthritis development by ADAM17/Tace in articular cartilage.
Use of mesoporous polydopamine nanoparticles as a stable drug-release system alleviates inflammation in knee osteoarthritis.
Arctiin-reinforced antioxidant microcarrier antagonizes osteoarthritis progression.
FABP4 secreted by M1-polarized macrophages promotes synovitis and angiogenesis to exacerbate rheumatoid arthritis.
Inhibition of HMGB1 suppresses inflammation and catabolism in temporomandibular joint osteoarthritis via NF-κB signaling pathway.
Upregulation of P2Y12 inhibits chondrocyte apoptosis in lumbar osteoarthritis through the PI3K/AKT signaling pathway.
Periostin promotes nucleus pulposus cells apoptosis by activating the Wnt/β-catenin signaling pathway.
Asiaticoside ameliorates osteoarthritis progression through activation of Nrf2/HO-1 and inhibition of the NF-κB pathway.
Epigallocatechin-3-O-gallate ameliorates oxidative stress-induced chondrocyte dysfunction and exerts chondroprotective effects via the Keap1/Nrf2/ARE signaling pathway.
Extracellular vesicles derived from human umbilical cord mesenchymal stem cells alleviate osteoarthritis of the knee in mice model by interacting with METTL3 to reduce m6A of NLRP3 in macrophage.
Histone demethylase JMJD3 downregulation protects against aberrant force-induced osteoarthritis through epigenetic control of NR4A1.
Mettl3 inhibits the apoptosis and autophagy of chondrocytes in inflammation through mediating Bcl2 stability via Ythdf1-mediated m(6)A modification.
T-2 toxin induces articular cartilage damage by increasing the expression of MMP-13 via the TGF-β receptor pathway.
Exosomes derived from platelet-rich plasma administration in site mediate cartilage protection in subtalar osteoarthritis.
Mesenchymal stromal cell-derived septoclasts resorb cartilage during developmental ossification and fracture healing.
Anti-inflammatory and immunomodulatory effects of the extracellular vesicles derived from human umbilical cord mesenchymal stem cells on osteoarthritis via M2 macrophages.
Fermentation supernatant of Staphylococcus aureus drives catabolism in chondrocytes via NF-κB signaling mediated increase of cholesterol metabolism.
SKI knockdown suppresses apoptosis and extracellular matrix degradation of nucleus pulposus cells via inhibition of the Wnt/β-catenin pathway and ameliorates disc degeneration.
Transforming growth factor-β receptors mediates matrix degradation and abnormal hypertrophy in T-2 toxin-induced hypertrophic chondrocytes.
Restoring the dampened expression of the core clock molecule BMAL1 protects against compression-induced intervertebral disc degeneration.
Cartilage Repair Using Clematis Triterpenoid Saponin Delivery Microcarrier, Cultured in a Microgravity Bioreactor Prior to Application in Rabbit Model.
dsRNA Induced IFNβ-MMP13 Axis Drives Corneal Wound Healing.
Stabilization of hypoxia-inducible factor-1α alleviates osteoarthritis via interacting with Per2 and resetting the circadian clock.
S100A10 regulates tumor necrosis factor alpha-induced apoptosis in chondrocytes via the reactive oxygen species/nuclear factor-kappa B pathway.
A plant-derived natural photosynthetic system for improving cell anabolism.
Shoc2 controls ERK1/2-driven neural crest development by balancing components of the extracellular matrix.
Nodakenin attenuates cartilage degradation and inflammatory responses in a mice model of knee osteoarthritis by regulating mitochondrial Drp1/ROS/NLRP3 axis.
Traumatic temporomandibular joint bony ankylosis in growing rats.
Osthole Suppresses Knee Osteoarthritis Development by Enhancing Autophagy Activated via the AMPK/ULK1 Pathway.
Metformin mitigates cholesterol accumulation via the AMPK/SIRT1 pathway to protect osteoarthritis chondrocytes.
An Injectable Hydrogel Scaffold Loaded with Dual-Drug/Sustained-Release PLGA Microspheres for the Regulation of Macrophage Polarization in the Treatment of Intervertebral Disc Degeneration.
Protective role of Achyranthes bidentata polysaccharides against chondrocyte extracellular matrix degeneration through lncRNA GAS5 in osteoarthritis.
Circular RNA circNFKB1 promotes osteoarthritis progression through interacting with ENO1 and sustaining NF-κB signaling.
PCB153 suppressed autophagy via PI3K/Akt/mTOR and RICTOR/Akt/mTOR signaling by the upregulation of microRNA-155 in rat primary chondrocytes.
Tri-n-butyl phosphate delays tissue repair by dysregulating neutrophil function in zebrafish.
TET enzymes regulate skeletal development through increasing chromatin accessibility of RUNX2 target genes.
Tangeretin suppresses osteoarthritis progression via the Nrf2/NF-κB and MAPK/NF-κB signaling pathways.
Itaconate attenuates osteoarthritis by inhibiting STING/NF-κB axis in chondrocytes and promoting M2 polarization in macrophages.
Ellagic acid attenuates interleukin-1β-induced oxidative stress and exerts protective effects on chondrocytes through the Kelch-like ECH-associated protein 1 (Keap1)/ Nuclear factor erythroid 2-related factor 2 (Nrf2) pathway.
Elevation of α-1,3 fucosylation promotes the binding ability of TNFR1 to TNF-α and contributes to osteoarthritic cartilage destruction and apoptosis.
Exosomes derived from hypoxia preconditioned mesenchymal stem cells laden in a silk hydrogel promote cartilage regeneration via the miR-205-5p/PTEN/AKT pathway.
Apigenin Alleviates Intervertebral Disc Degeneration via Restoring Autophagy Flux in Nucleus Pulposus Cells.
LncRNA Malat-1 From MSCs-Derived Extracellular Vesicles Suppresses Inflammation and Cartilage Degradation in Osteoarthritis.
Reducing Inflammation and Vascular Invasion in Intervertebral Disc Degeneration via Cystathionine-γ-Lyase Inhibitory Effect on E-Selectin.
Osteocyte Apoptosis Contributes to Cold Exposure-induced Bone Loss.
Exosomes Isolated From Bone Marrow Mesenchymal Stem Cells Exert a Protective Effect on Osteoarthritis via lncRNA LYRM4-AS1-GRPR-miR-6515-5p.
Single-Cell Profiles of Age-Related Osteoarthritis Uncover Underlying Heterogeneity Associated With Disease Progression.
Leptin Induced TLR4 Expression via the JAK2-STAT3 Pathway in Obesity-Related Osteoarthritis.
MCC950, the NLRP3 Inhibitor, Protects against Cartilage Degradation in a Mouse Model of Osteoarthritis.
Bardoxolone-Methyl Prevents Oxidative Stress-Mediated Apoptosis and Extracellular Matrix Degradation in vitro and Alleviates Osteoarthritis in vivo.
1,25-Dihydroxyvitamin D Inhibits Osteoarthritis by Modulating Interaction Between Vitamin D Receptor and NLRP3 in Macrophages.
Aberrant Fluid Shear Stress Contributes to Articular Cartilage Pathogenesis via Epigenetic Regulation of ZBTB20 by H3K4me3.
Exosome-Encapsulated microRNA-127-3p Released from Bone Marrow-Derived Mesenchymal Stem Cells Alleviates Osteoarthritis Through Regulating CDH11-Mediated Wnt/β-Catenin Pathway.
Isovitexin Depresses Osteoarthritis Progression via the Nrf2/NF-κB Pathway: An in vitro Study.
Physalin A Inhibits MAPK and NF-κB Signal Transduction Through Integrin αVβ3 and Exerts Chondroprotective Effect.
Therapeutic Effects of Naringin in Rheumatoid Arthritis: Network Pharmacology and Experimental Validation.
Exhausting circ_0136474 and Restoring miR-766-3p Attenuate Chondrocyte Oxidative Injury in IL-1β-Induced Osteoarthritis Progression Through Regulating DNMT3A.
MicroRNA-497 Reduction and Increase of Its Family Member MicroRNA-424 Lead to Dysregulation of Multiple Inflammation Related Genes in Synovial Fibroblasts With Rheumatoid Arthritis.
Injectable exosome-functionalized extracellular matrix hydrogel for metabolism balance and pyroptosis regulation in intervertebral disc degeneration.
Integrative analysis of genome-wide DNA methylation and single-nucleotide polymorphism identified ACSM5 as a suppressor of lumbar ligamentum flavum hypertrophy.
18β-Glycyrrhetinic acid inhibits IL-1β-induced inflammatory response in mouse chondrocytes and prevents osteoarthritic progression by activating Nrf2.
Therapeutic effect of neohesperidin on TNF-α-stimulated human rheumatoid arthritis fibroblast-like synoviocytes.
Frugoside delays osteoarthritis progression via inhibiting miR-155-modulated synovial macrophage M1 polarization.
SP600125 Restored TNF-α-Induced Impaired Chondrogenesis in Bone Mesenchymal Stem Cells and Its Antiosteoarthritis Effect in Mice.
Compressive force regulates cementoblast migration via downregulation of autophagy.
Effects of mechanical stress and deficiency of dihydrotestosterone or 17β-estradiol on Temporomandibular Joint Osteoarthritis in mice.
Zonal-Layered Chondrocyte Sheets for Repairment of Full-Thickness Articular Cartilage Defect: A Mini-Pig Model.
MFG-E8 regulated by miR-99b-5p protects against osteoarthritis by targeting chondrocyte senescence and macrophage reprogramming via the NF-κB pathway.
Decreased miR-214-3p activates NF-κB pathway and aggravates osteoarthritis progression.
Senolytic agent Quercetin ameliorates intervertebral disc degeneration via the Nrf2/NF-κB axis.
d-Mannose suppresses osteoarthritis development in vivo and delays IL-1β-induced degeneration in vitro by enhancing autophagy activated via the AMPK pathway.
Cardamonin protects nucleus pulposus cells against IL-1β-induced inflammation and catabolism via Nrf2/NF-κB axis.
Inhibition of HDAC6 by Tubastatin A reduces chondrocyte oxidative stress in chondrocytes and ameliorates mouse osteoarthritis by activating autophagy.
BMP5 silencing inhibits chondrocyte senescence and apoptosis as well as osteoarthritis progression in mice.
Staphylococcus aureus on the effect of expression of MMPs/TIMPs and uPA system in bovine mammary fibroblasts.
Phgdh serves a protective role in Il‑1β induced chondrocyte inflammation and oxidative‑stress damage.
AMD3465 (hexahydrobromide) rescues the MG63 osteoblasts against the apoptosis induced by high glucose.
Global Deletion of Pannexin 3 Resulting in Accelerated Development of Aging-Induced Osteoarthritis in Mice.
TGF-β/Alk5 signaling prevents osteoarthritis initiation via regulating the senescence of articular cartilage stem cells.
α-Cyperone (CYP) down-regulates NF-κB and MAPKs signaling, attenuating inflammation and extracellular matrix degradation in chondrocytes, to ameliorate osteoarthritis in mice.
Activation of transient receptor potential vanilloid 4 protects articular cartilage against inflammatory responses via CaMKK/AMPK/NF-κB signaling pathway.
Metabolic reprogramming in chondrocytes to promote mitochondrial respiration reduces downstream features of osteoarthritis.
LncRNA H19-Derived miR-675-5p Accelerates the Invasion of Extravillous Trophoblast Cells by Inhibiting GATA2 and Subsequently Activating Matrix Metalloproteinases.
The Role of Panx3 in Age-Associated and Injury-Induced Intervertebral Disc Degeneration.
Endoplasmic reticulum stress pathway mediates T-2 toxin-induced chondrocyte apoptosis.
Acetabular development and fate of inverted limbus in rabbits: Experimental observation from an animal model.
Glucagon-like peptide-1 receptor activation maintains extracellular matrix integrity by inhibiting the activity of mitogen-activated protein kinases and activator protein-1.
Silencing BLNK protects against interleukin-1β-induced chondrocyte injury through the NF-κB signaling pathway.
Physiological Reloading Recovers Histologically Disuse Atrophy of the Articular Cartilage and Bone by Hindlimb Suspension in Rat Knee Joint.
MicroRNA-4423-3p inhibits proliferation of fibroblast-like synoviocytes by targeting matrix metalloproteinase 13 in rheumatoid arthritis.
Role of the hippo signaling pathway in the extracellular matrix degradation of chondrocytes induced by fluoride exposure.
TGF-β1-stimulation of NFATC2 and ATF3 proteins and their interaction for matrix metalloproteinase 13 expression in human breast cancer cells.
Involvement of Transient Receptor Potential Vanilloid Channel 2 in the Induction of Lubricin and Suppression of Ectopic Endochondral Ossification in Mouse Articular Cartilage.
Scleraxis expressing scleral cells respond to inflammatory stimulation.
Suramin attenuates intervertebral disc degeneration by inhibiting NF-κB signalling pathway.
METTL3 involves the progression of osteoarthritis probably by affecting ECM degradation and regulating the inflammatory response.
Oroxylin A attenuates IL-1β-induced inflammatory reaction via inhibiting the activation of the ERK and PI3K/AKT signaling pathways in osteoarthritis chondrocytes.
Effects of HDAC4 on IL-1β-induced matrix metalloproteinase expression regulated partially through the WNT3A/β-catenin pathway.
ZIP8 mediates the extracellular matrix degradation of nucleus pulposus cells via NF-κB signaling pathway.
OPN Deficiency Increases the Severity of Osteoarthritis Associated with Aberrant Chondrocyte Senescence and Apoptosis and Upregulates the Expression of Osteoarthritis-Associated Genes.
Punicalagin Inhibits Tert-Butyl Hydroperoxide-Induced Apoptosis and Extracellular Matrix Degradation in Chondrocytes by Activating Autophagy and Ameliorates Murine Osteoarthritis.
LncRNA TRPC7-AS1 regulates nucleus pulposus cellular senescence and ECM synthesis via competing with HPN for miR-4769-5p binding.
A chondroprotective effect of moracin on IL-1β-induced primary rat chondrocytes and an osteoarthritis rat model through Nrf2/HO-1 and NF-κB axes.
TLR4 contributes to the damage of cartilage and subchondral bone in discectomy-induced TMJOA mice.
S-allyl cysteine reduces osteoarthritis pathology in the tert-butyl hydroperoxide-treated chondrocytes and the destabilization of the medial meniscus model mice via the Nrf2 signaling pathway.
IL-37 inhibits M1-like macrophage activation to ameliorate temporomandibular joint inflammation through the NLRP3 pathway.
Heparan sulfate deficiency leads to hypertrophic chondrocytes by increasing bone morphogenetic protein signaling.
miR-873-3p targets HDAC4 to stimulate matrix metalloproteinase-13 expression upon parathyroid hormone exposure in rat osteoblasts.
Overexpression of MIG-6 in the cartilage induces an osteoarthritis-like phenotype in mice.
Reducing macrophage numbers alleviates temporomandibular joint ankylosis.
Oxymatrine suppresses IL-1β-induced degradation of the nucleus pulposus cell and extracellular matrix through the TLR4/NF-κB signaling pathway.
Paclitaxel-induced peripheral neuropathy is caused by epidermal ROS and mitochondrial damage through conserved MMP-13 activation.
Long non-coding RNA SNHG15 is a competing endogenous RNA of miR-141-3p that prevents osteoarthritis progression by upregulating BCL2L13 expression.
Casticin Attenuates Osteoarthritis-Related Cartilage Degeneration by Inhibiting the ROS-Mediated NF-κB Signaling Pathway in vitro and in vivo.
Curcumol may reverse early and advanced liver fibrogenesis through downregulating the uPA/uPAR pathway.
MicroRNA-675-3p regulates IL-1β-stimulated human chondrocyte apoptosis and cartilage degradation by targeting GNG5.
The protective effect of myricitrin in osteoarthritis: An in vitro and in vivo study.
MiR-455-3p reduces apoptosis and alleviates degeneration of chondrocyte through regulating PI3K/AKT pathway.
Hypoxic mast cells accelerate the proliferation, collagen accumulation and phenotypic alteration of human lung fibroblasts.
Targeting exosome-associated human antigen R attenuates fibrosis and inflammation in diabetic heart.
MicroRNA-377-3p alleviates IL-1β-caused chondrocyte apoptosis and cartilage degradation in osteoarthritis in part by downregulating ITGA6.
Protective effect of resveratrol on obesity-related osteoarthritis via alleviating JAK2/STAT3 signaling pathway is independent of SOCS3.
Inhibition of PI3K/Akt/NF-κB signaling by Aloin for ameliorating the progression of osteoarthritis: In vitro and in vivo studies.
Exogenous hydrogen sulfide inhibits apoptosis by regulating endoplasmic reticulum stress-autophagy axis and improves myocardial reconstruction after acute myocardial infarction.
Stachydrine ameliorates the progression of intervertebral disc degeneration via the PI3K/Akt/NF-κB signaling pathway: in vitro and in vivo studies.
Glycitin Suppresses Cartilage Destruction of Osteoarthritis in Mice.
Crenigacestat, a selective NOTCH1 inhibitor, reduces intrahepatic cholangiocarcinoma progression by blocking VEGFA/DLL4/MMP13 axis.
Macromechanics and polycaprolactone fiber organization drive macrophage polarization and regulate inflammatory activation of tendon in vitro and in vivo.
Vitamin D3 protects articular cartilage by inhibiting the Wnt/β-catenin signaling pathway.
IκB kinase α: an independent prognostic factor that promotes the migration and invasion of oral squamous cell carcinoma.
Keratocytes promote corneal neovascularization through VEGFr3 induced by PPARα-inhibition.
FTO promotes cell proliferation and migration in esophageal squamous cell carcinoma through up-regulation of MMP13.
25-HC promotes hepatocellular carcinoma metastasis through up-regulation of TLR4 dependent FABP4.
A Compound of Chinese Herbs Protects against Alcoholic Liver Fibrosis in Rats via the TGF-β1/Smad Signaling Pathway.
KLF2 Protects against Osteoarthritis by Repressing Oxidative Response through Activation of Nrf2/ARE Signaling In Vitro and In Vivo.
Nobiletin Inhibits IL-1β-Induced Inflammation in Chondrocytes via Suppression of NF-κB Signaling and Attenuates Osteoarthritis in Mice.
Targeting the IL-1β/IL-1Ra pathways for the aggregation of human islet amyloid polypeptide in an ex vivo organ culture system of the intervertebral disc.
Effects of simvastatin on matrix metalloproteinase regulation in IL-1β-induced SW1353 cells.
Alleviation of murine osteoarthritis by deletion of the focal adhesion mechanosensitive adapter, Hic-5.
Development of a Mouse Model of Knee Osteoarthritis Based on Obesity and Bipedal Walking.
ZnO nanoparticles inhibit the activity of Porphyromonas gingivalis and Actinomyces naeslundii and promote the mineralization of the cementum.
25-HC decreases the sensitivity of human gastric cancer cells to 5-fluorouracil and promotes cells invasion via the TLR2/NF-κB signaling pathway.
Cortistatin binds to TNF-α receptors and protects against osteoarthritis.
miR-100-5p-abundant exosomes derived from infrapatellar fat pad MSCs protect articular cartilage and ameliorate gait abnormalities via inhibition of mTOR in osteoarthritis.
miR-93-5p attenuates IL-1β-induced chondrocyte apoptosis and cartilage degradation in osteoarthritis partially by targeting TCF4.
Adamts17 is involved in skeletogenesis through modulation of BMP-Smad1/5/8 pathway.
Quercetin alleviates rat osteoarthritis by inhibiting inflammation and apoptosis of chondrocytes, modulating synovial macrophages polarization to M2 macrophages.
Reduced PDGF-AA in subchondral bone leads to articular cartilage degeneration after strenuous running.
Inhibition of Ihh Reverses Temporomandibular Joint Osteoarthritis via a PTH1R Signaling Dependent Mechanism.
Effects of IL-1β on MMP-9 Expression in Cementoblast-Derived Cell Line and MMP-Mediated Degradation of Type I Collagen.
SIRT3 Activation by Dihydromyricetin Suppresses Chondrocytes Degeneration via Maintaining Mitochondrial Homeostasis.
mTOR-mediated inactivation of 4E-BP1, an inhibitor of translation, precedes cartilage degeneration in rat osteoarthritic knees.
Differential effects of high-physiological oestrogen on the degeneration of mandibular condylar cartilage and subchondral bone.
Loss of Fgfr1 in chondrocytes inhibits osteoarthritis by promoting autophagic activity in temporomandibular joint.
ETV4 transcription factor and MMP13 metalloprotease are interplaying actors of breast tumorigenesis.
Postnatal deletion of Alk5 gene in meniscal cartilage accelerates age-dependent meniscal degeneration in mice.
Stromal cell‑derived factor‑1 induces matrix metalloproteinase expression in human endplate chondrocytes, cartilage endplate degradation in explant culture, and the amelioration of nucleus pulposus degeneration in vivo.
Toxoplasma gondii GRA15(II) effector-induced M1 cells ameliorate liver fibrosis in mice infected with Schistosomiasis japonica.
Emodin ameliorates cartilage degradation in osteoarthritis by inhibiting NF-κB and Wnt/β-catenin signaling in-vitro and in-vivo.
Tumor-derived exosomes educate dendritic cells to promote tumor metastasis via HSP72/HSP105-TLR2/TLR4 pathway.
Chondroprotective Effects and Multitarget Mechanisms of Fu Yuan Capsule in a Rat Osteoarthritis Model.
Upregulation of FBXW7 Suppresses Renal Cancer Metastasis and Epithelial Mesenchymal Transition.
Cartilage-specific deletion of Alk5 gene results in a progressive osteoarthritis-like phenotype in mice.
Icariin inhibits MMP‑1, MMP‑3 and MMP‑13 expression through MAPK pathways in IL‑1β‑stimulated SW1353 chondrosarcoma cells.
Simvastatin Inhibits IL-1β-Induced Apoptosis and Extracellular Matrix Degradation by Suppressing the NF-kB and MAPK Pathways in Nucleus Pulposus Cells.
Potential Involvement of the IL-6/JAK/STAT3 Pathway in the Pathogenesis of Intervertebral Disc Degeneration.
AMPK deficiency in chondrocytes accelerated the progression of instability-induced and ageing-associated osteoarthritis in adult mice.
Chlorogenic acid prevents inflammatory responses in IL‑1β‑stimulated human SW‑1353 chondrocytes, a model for osteoarthritis.
Conditional knockdown of hyaluronidase 2 in articular cartilage stimulates osteoarthritic progression in a mice model.
Fibroblast Growth Factor Receptor 3 Inhibits Osteoarthritis Progression in the Knee Joints of Adult Mice.
Iron overload in a murine model of hereditary hemochromatosis is associated with accelerated progression of osteoarthritis under mechanical stress.
Conditional knockout of tissue factor pathway inhibitor 2 in vascular endothelial cells accelerates atherosclerotic plaque development in mice.
Exogenous fibroblast growth factor 9 attenuates cartilage degradation and aggravates osteophyte formation in post-traumatic osteoarthritis.
Conditional Deletion of Fgfr3 in Chondrocytes leads to Osteoarthritis-like Defects in Temporomandibular Joint of Adult Mice.
Levofloxacin increases apoptosis of rat annulus fibrosus cells via the mechanism of upregulating MMP-2 and MMP-13.
Deletion of Dual Specificity Phosphatase 1 Does Not Predispose Mice to Increased Spontaneous Osteoarthritis.
17β-estradiol protects against apoptosis induced by interleukin-1β in rat nucleus pulposus cells by down-regulating MMP-3 and MMP-13.
Deletion of Panx3 Prevents the Development of Surgically Induced Osteoarthritis.
Potent effects of dioscin against liver fibrosis.
Keratocytes create stromal spaces to promote corneal neovascularization via MMP13 expression.
Protective effects of biochanin A on articular cartilage: in vitro and in vivo studies.
Chondroprotective effects and multi-target mechanisms of Icariin in IL-1 beta-induced human SW 1353 chondrosarcoma cells and a rat osteoarthritis model.
Loss of Vhl in cartilage accelerated the progression of age-associated and surgically induced murine osteoarthritis.
Suppression of hyaluronan synthesis alleviates inflammatory responses in murine arthritis and in human rheumatoid synovial fibroblasts.
Celastrol, an inhibitor of heat shock protein 90β potently suppresses the expression of matrix metalloproteinases, inducible nitric oxide synthase and cyclooxygenase-2 in primary human osteoarthritic chondrocytes.
Anti-arthritic effects of crocin in interleukin-1β-treated articular chondrocytes and cartilage in a rabbit osteoarthritic model.
Genetic inhibition of fibroblast growth factor receptor 1 in knee cartilage attenuates the degeneration of articular cartilage in adult mice.
Drug delivery from internally implanted biomedical devices used in traumatology and in orthopedic surgery.
Jiang J, Xu Y, Dai T, Chen J, Li S, Meng Q
PloS one 2026;21(2):e0342242
PloS one 2026;21(2):e0342242
MSC Exosomes and Rutin-Chitosan-Pectin Nanoparticles Synergize to Ameliorate Adjuvant Arthritis via Th1/Th2 Modulation, MMP Suppression, Nrf2 Upregulation, and Antioxidant Boost.
Moftah KM, Hozayen WG, Hasona NA, Al-Muzafar HM, Amin KA, Alshwyeh HA, Zoheir KMA, Ahmed OM
Stem cells international 2026;2026:3586025
Stem cells international 2026;2026:3586025
Mitochondrial Dynamics Disorder Drives Nucleus Pulposus Cell Senescence in Lumbar Scoliosis of Aging Bipedal Rats Under Asymmetric Force.
Wang J, Cao D, Peng J, Zhou X, Liu Z, Wang X, Zhang A, Shen K
Stem cells international 2026;2026:1581661
Stem cells international 2026;2026:1581661
Artemisinin exerts anti-inflammatory effects in osteoarthritis through the inhibition of TGF-β1 signaling.
Zheng X, Yu B, Song Y, Chen Y, Li Z, Yao J
Frontiers in immunology 2026;17:1717045
Frontiers in immunology 2026;17:1717045
Dissolvable microneedles loaded with denosumab alleviate knee osteoarthritis in rodent and canine models by inhibiting macrophage senescence.
Ming C, Bi D, Tian H, Liu W, Li H, Hu Y, Song Z, Xu D, Xu H, Li H, Lan S, Xu W, Chen W, Li Q, Feng J, Cao Q, Wang X, Fan P, Zhu J, Yu W, Ming C, Dai Z, Liu Y, Tong W
Theranostics 2026;16(1):325-344
Theranostics 2026;16(1):325-344
Quercetin attenuates tendon stem/progenitor cell senescence and promotes aged tendon repair via AKT/NF-κB/NLRP3-mediated mitophagy activation.
Wang H, Gao YC, Ming-Zhang, Dai GC, Lu PP, Li YJ, Cao MM, Liu XY, Sheng RW, Shi L, Zhang C, Cui WG, Rui YF
Journal of advanced research 2026 May;83:741-758
Journal of advanced research 2026 May;83:741-758
Astragalus membranaceus Polysaccharides Attenuate Osteoarthritis in Human Primary Chondrocytes and in Animal Model: Mechanism Study Using RNA-Seq and Network Pharmacology.
Xu H, Li Y, Wang J, Xin Y, Xu Q, Qin X, Yang X, Yan Y, Chen Q, Chen Y, Zhang Y, Lu C, Xu K, Wang X
Phytotherapy research : PTR 2026 May;40(5):2249-2269
Phytotherapy research : PTR 2026 May;40(5):2249-2269
Cinnamyl Alcohol Attenuates Osteoarthritis Progression via PIGR-Mediated Regulation of Chondrocyte Senescence and Cartilage Homeostasis.
Zhu Q, You Q, Deng J, Tang H, Hu Y, Liao Y, Miao Y
Journal of medicinal food 2026 May;29(5):279-293
Journal of medicinal food 2026 May;29(5):279-293
Detoxification of T-2 toxin in human chondrocytes due to its hydroxylation by carboxylesterases and arylacetamide deacetylase in the liver.
Cheng S, Shi S, Cheng B, Liu C, Yang X, Liu L, Liu H, Wen Y, Tinkov AA, Skalny AV, Jia Y, Zhang F
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2026 May;211:116007
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2026 May;211:116007
Alzheimer's Disease Risk Factor APOE4 Exerts Dimorphic Effects on Female Bone.
Schurman CA, Kaur G, Kaya S, Bons J, Aguirre CG, Liu Q, King CD, Wilson KA, Baker HL, Hady M, Luna NM, Bieri G, Villeda SA, Ellerby LM, Schilling B, Alliston T
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 May;13(28):e23511
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 May;13(28):e23511
Targeted knockdown of Piezo1 in synovial macrophages attenuates osteoarthritis development.
Yan Z, Wu D, Zhao H, Guan H, Chen J, Huang C, Chen X, Deng X, Hu J, Wang J, Zhang Y
Journal of orthopaedic translation 2026 Mar;57:101053
Journal of orthopaedic translation 2026 Mar;57:101053
Hypoxia-preconditioned bone marrow mesenchymal stem cell-derived exosomes ameliorate knee osteoarthritis by promoting cartilage regeneration and alleviating pain in rats.
Zhang B, Lu C, Dou B, Gu W, Li K
Regenerative therapy 2026 Mar;31:101049
Regenerative therapy 2026 Mar;31:101049
A novel MMP13 frameshift variant causes short stature via enhanced MMP13-HSPA5 interaction and activated endoplasmic reticulum stress.
Lu H, Feng X, Dai S, Zhu Y, Yuan K, Chen Y, Zhu J, Fang Y, Yan Q, Wang C
Clinical and translational medicine 2026 Mar;16(3):e70648
Clinical and translational medicine 2026 Mar;16(3):e70648
The TRAF6/SPP1 axis participates in osteoarthritis progression through regulating the catabolism and anabolism of cartilage matrix.
Yao J, Huang J, Li C, Shang J, Lin X, Zhou X, Lu Y
Scientific reports 2026 Mar 4;16(1)
Scientific reports 2026 Mar 4;16(1)
Phellopterin Inhibits Inflammation and Relieves Cartilage Degradation by Suppressing MAPK Signaling in Osteoarthritis.
Sun C, Wang Y, Zhang K, Liu B
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Mar 31;40(6):e71698
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Mar 31;40(6):e71698
Natural photosynthetic system for restoring homeostasis of animal organelle interaction network.
Xia C, Dai Z, Wang Y, Yu J, Wang Z, Huang Z, Pan K, Yang K, Chen Y, Zhong P, Gu C, Fan S, Lin X, Chen P
Nature communications 2026 Mar 31;17(1)
Nature communications 2026 Mar 31;17(1)
Immunomodulatory and anabolic biphasic scaffold with hierarchical biomimetic structure directed osteochondral defect repair.
Yu H, Wang W, Wang H, Zhang W, Zheng Y, Chen L, Huang S, Yan W, Yao Q
NPJ Regenerative medicine 2026 Mar 3;11(1)
NPJ Regenerative medicine 2026 Mar 3;11(1)
α-Ketoglutarate protects against cartilage damage via epigenetically driven metabolic reprogramming in osteoarthritis models.
Li S, Huang J, Shang T, Lu L, Fan OR, Jin P, Zou X, Cai Z, Lu W, Jia S, Li L, Fang K, Niu F, Li J, Zhao C, Wang Q, Sun R, Shi S, Yin F, Zhang Y, Sun YE, Cui L
The Journal of clinical investigation 2026 Mar 2;136(5)
The Journal of clinical investigation 2026 Mar 2;136(5)
Increased Expression of Connexin 43 Promotes Wnt/β-Catenin Signaling and the Progression of Temporomandibular Joint Osteoarthritis.
Cai S, Yang X, Chen Z, Chen S, Chen L, Cai J, Cai J, Zou Y, Xu L, Wang H
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Mar 15;40(5):e71623
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Mar 15;40(5):e71623
Phycocyanin-functionalized selenium nanoparticles attenuate osteoarthritis through ferroptosis suppression and modulation of the MAPK pathway.
Hu J, Luo P, Zhang W, Chen T, Yang X, Chen Z, Huang S, Zhang X, Kuang Z, Zhang B
Materials today. Bio 2026 Jun;38:103113
Materials today. Bio 2026 Jun;38:103113
Membrane-camouflaged nanoparticle alleviates intervertebral disc degeneration via oxidative stress suppression and autophagy activation.
Niu Z, Fan Y, Chen J, Ji L, Tong Y, Yao L, Ding S, Xu H, Chen J, Zhang Q, Zhao C, Chen J, Bi Q, Xia C
Materials today. Bio 2026 Jun;38:103038
Materials today. Bio 2026 Jun;38:103038
Therapeutic effects of Tetramethylpyrazine on Cartilage in Rat Model of Post-traumatic Osteoarthritis.
Duan Z, Gao H, Li P, Tang S, He B
Regenerative therapy 2026 Jun;32:101098
Regenerative therapy 2026 Jun;32:101098
ALOX5 knockdown alleviates cartilage damage in osteoarthritis by inhibiting the NF-κB signaling pathway.
Cheng G, Chen K, Wang Z, Chen H, Shen Y
Cytokine 2026 Jun;202:157150
Cytokine 2026 Jun;202:157150
Pterostilbene inhibits ferritinophagy-mediated ferroptosis via the NRF2/NCOA4/FTH1 axis and alleviates intervertebral disc degeneration through nanoliposomal delivery.
Song Z, Yan M, Lv X, Zhang S, Kou H, Han H, Wang Z, Chen Y, Shi L, Shao Z, Hu B, Chen S, Liu H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158051
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158051
VDAC1-mediated cytosolic leakage of mtDNA triggers pyroptosis of nucleus pulposus cells by activating the TLR9 signaling pathway.
Hu T, Yan M, Chen Y, Chen S, Song Z, Jing X, Hu B, Liu H
Cellular signalling 2026 Jun;142:112387
Cellular signalling 2026 Jun;142:112387
Long-acting triamcinolone acetonide prodrug microcrystals for sustained intra-articular treatment of osteoarthritis.
Wang X, Dong Y, Lin X, Deng X, Li X, Shi X, Zhou Y, Yao X, Yu N, Guo S
Journal of controlled release : official journal of the Controlled Release Society 2026 Jun 10;394:114868
Journal of controlled release : official journal of the Controlled Release Society 2026 Jun 10;394:114868
Artificial mitochondria ameliorates osteoarthritis through restoring cellular energy metabolism homeostasis.
Yan W, Chen Y, Wu H, Gao Z, Hu X, Ao Y, Mao C, Wan M
Bioactive materials 2026 Jul;61:940-966
Bioactive materials 2026 Jul;61:940-966
Collagen II hydrogel-mediated sustained delivery of lacosamide attenuates cartilage degeneration and pain in osteoarthritis.
He C, Huang G, Moradi L, Bi J, Yang X, Liu X, Cui X, Varthi A, Wiznia DH, Waxman SG, Fu W, Liu CJ
Bioactive materials 2026 Jul;61:640-656
Bioactive materials 2026 Jul;61:640-656
YAP in synovial macrophages mitigates mechanically-induced osteoarthritis by preserving mitochondrial fusion.
Cheng Y, Guo ZL, Gu YF, Li WL, Zhang WB
Cellular signalling 2026 Jul;143:112430
Cellular signalling 2026 Jul;143:112430
Targeting of CIRP attenuates osteoarthritis progression via suppressing TLR4/NF‑κB/NLRP3 signaling axis.
Sun W, Liao Y, Feng J, Liang J, He Q, Cui Y, Huang D, Shi H, You W, Sun W, Yi Q
International journal of molecular medicine 2026 Jan;57(1)
International journal of molecular medicine 2026 Jan;57(1)
Intermittent intra-articular delivery of FGF8b enhances cartilage homeostasis and attenuates osteoarthritis progression.
Peng X, Han J, Tian Y, Li X, Zhang X, Li S, Yang J, Chen L, Zhou S, Su N, Mao X, Zhang B, Chen H, Yang J, Jin M, Li C, Jiang W, Liu P, Xie Y, Kuang L, Chen L
Journal of orthopaedic translation 2026 Jan;56:101037
Journal of orthopaedic translation 2026 Jan;56:101037
Early Intervention of Subchondral Bone Resorption Mitigates Cartilage Degeneration in TMJOA.
Cao MN, Feng SY, Gao CC, Xiao Y, Li YX, Lei J, Fu KY
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2026 Jan;55(1):133-146
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2026 Jan;55(1):133-146
Dual-PPARα/δ agonist H11 alleviates tendinopathy via modulating the Nrf2/HO-1/GPX4 pathway.
Lu Y, Yang S, Liu H, Zhang Y, Li Z, Lu J, Jiang Q, Xu X
Free radical biology & medicine 2026 Jan;242:333-344
Free radical biology & medicine 2026 Jan;242:333-344
Pharmacological inhibition of PGK1 by genipin reduces inflammation and oxidative damage in osteoarthritis.
Li M, Peng Y, Xiao Q, Chen S, Zhang C, Chen H, Zhao Y, Chang S, Qiu L, Zhang L, Guo X, Fu Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157729
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157729
An injectable dihydroartemisinin nanocomposite hydrogel for dual-targeting PANoptosis and inflammation to treat osteoarthritis.
Li Q, Chen L, Sun Y, Wang C, Sun Y, Lu K, Li L, Sun H, Liu M
Journal of nanobiotechnology 2026 Jan 29;24(1)
Journal of nanobiotechnology 2026 Jan 29;24(1)
PTPN22 as a therapeutic target in intervertebral disc degeneration: Modulating mitophagy and pyroptosis through the PI3K/AKT/mTOR axis.
Liang H, Yang S, Huang Y, Zhu Y, Wu Q, Wu Z, Li S, Shi Y, Chen Z, Jin H, Wang X
Journal of advanced research 2026 Feb;80:775-789
Journal of advanced research 2026 Feb;80:775-789
Promoter Methylation of WIF1 is Involved in IL-17-Induced Chondrocyte Inflammatory Injury and Matrix Degradation via Promoting Wnt5a/MAPK-JNK Signaling.
Chen X, Chen X, Xie J, Guo D
Molecular biotechnology 2026 Feb;68(2):496-506
Molecular biotechnology 2026 Feb;68(2):496-506
Injectable microgels loaded with programmable WELNs based on mendelian randomization macroanalysis alleviate osteoarthritis by restoring the circadian rhythm.
Yan R, Li W, Zhao D, Zhao J, Ying S, Xiang L, Wang H, He T, Zhao C, Cui W, Zheng C, Yang L
Bioactive materials 2026 Feb;56:483-508
Bioactive materials 2026 Feb;56:483-508
Integrating TWAS, chemical-genomic networks, and experimental models: melatonin as a ferroptosis inhibitor in osteoarthritis therapy.
Feng R, Aihaiti Y, Yu H, Xu K, Lu C, Xu P
Clinical rheumatology 2026 Feb;45(2):1559-1572
Clinical rheumatology 2026 Feb;45(2):1559-1572
Protopine attenuates hepatic fibrosis via HDAC6-mediated NLRP3 inflammasome activation.
Li Y, Liang M, Wang X, Zhu Q, Nie J, Sun L
Bioorganic chemistry 2026 Feb;169:109394
Bioorganic chemistry 2026 Feb;169:109394
NSUN3-mediated m5C modification of FABP5 regulates lipid droplets through autophagy to alleviate osteoarthritis progression.
Luo Z, Liu Y, Cheng B, Li Z, Yang L, Cheng C, Fang H, Liu Y
Cellular signalling 2026 Feb;138:112238
Cellular signalling 2026 Feb;138:112238
Oxysophoridine promotes osteoarthritis repair via GSH system activation and ROS suppression.
Tu J, Peng Z, Sun X, Liu H, Zhao J, Xu B, Zhu X, Liu B
Scientific reports 2026 Feb 3;16(1):7092
Scientific reports 2026 Feb 3;16(1):7092
Paeoniflorin Alleviates Metabolic Dysfunction-Associated Steatotic Liver Disease by Inhibiting Hepatic Lipogenesis and Inflammation.
Wei SZ, Dong Y, Zhou HY, Yang J, Lu JF, Zhao YL, Zhao Y, Lu JF
Inflammation 2026 Feb 26;49(1)
Inflammation 2026 Feb 26;49(1)
Glibenclamide attenuates osteoarthritis by suppressing NLRP3 inflammasome activation in synovial macrophages through the MAPK pathway.
Ni J, Zhou H, Shen K, Xu H, Wang J, Liu J, Liu F
Journal of translational medicine 2026 Feb 26;24(1)
Journal of translational medicine 2026 Feb 26;24(1)
Synergistic Effects of Nutritional Formula on Joint Inflammation Through Modulation of Bone Metabolism in Rats.
Wang H, Wang Y, Fan D, Niu Z, Su H, Li A, Kou R, Yue Z, Wu S, Lv H, Ji X, Hu Y, Zhao Y, Wang S
Nutrients 2026 Feb 26;18(5)
Nutrients 2026 Feb 26;18(5)
Activated Rac1 promotes chondrocyte apoptosis through the NF-κB pathway in lumbar facet joint osteoarthritis.
Wang X, Xue P, Zhang J, Jin H, Jiang J, Xu G, Cui Z
Journal of molecular histology 2026 Feb 25;57(2)
Journal of molecular histology 2026 Feb 25;57(2)
High-intensity interval training remodels perineuronal nets in the medial prefrontal cortex to drive microglial polarization and alleviate osteoarthritis pain.
Lin C, Zhang X, Ye Z, Zhou F, Huang K, Zhu S, Chen A, Li X
Scientific reports 2026 Feb 20;16(1)
Scientific reports 2026 Feb 20;16(1)
Synergistic microenvironment therapy: a dual-function nanogel of supramolecular collagen ll-mimetic matrix and antioxidant MXene for attenuating intervertebral disc degeneration.
Lyu G, Gao Z, Cao Z, Zhou Q, Chen Y, Yang S, Liang H, Lu X, Li S, Wang X, Sun S, Gao X, Zhou Y, Wu A, Zhou X, Wang X
Journal of nanobiotechnology 2026 Feb 19;24(1)
Journal of nanobiotechnology 2026 Feb 19;24(1)
CCL11 promotes hepatocellular carcinoma recurrence after surgery by potentiating immunosuppressive CCR5 + CD206 + M2-like macrophages and promoting tumor invasiveness.
Wang J, Yeung OW, Qiu W, Pang L, Liu J, Yang X, Zeng S, Ding T, Wang Z, Hu Z, Cheung TT, Man K, Ng KT
Cell death & disease 2026 Feb 19;17(1)
Cell death & disease 2026 Feb 19;17(1)
Synovial inflammatory macrophage-derived extracellular vesicles exacerbate cartilage lesions with a FMRP-selectively sorted manner in osteoarthritis.
Zhao S, Wang J, Xue M, Wu B, Sheng L, Wen Y, Wang G, Song J, Du D, Xu J
Bone research 2026 Feb 17;14(1):26
Bone research 2026 Feb 17;14(1):26
KLK8 promotes cartilage degradation and pyroptosis in osteoarthritis by activating the NF-κB and NLRP3 inflammasome pathways.
Xu L, Jiang Z, Li H
Tissue & cell 2026 Aug;101:103427
Tissue & cell 2026 Aug;101:103427
RP13-516M14.1 Regulates Autophagy Through miR-429 via Both a ceRNA Network and Direct Interaction.
Yang Z, Zeng A, Yu B, Xie C, Zhu W, Liu H, Gu C, Fu M
Biochemical genetics 2026 Apr;64(2):2416-2447
Biochemical genetics 2026 Apr;64(2):2416-2447
Injectable microgels carrying engineered biomimetic nanoparticles for osteoarthritis therapy via dual-targeted senescent chondrocyte clearance and endogenous repair promotion.
Wang P, Zhao H, Zhang S, Guo Y, Xing X, Zhou S, Yang S, Wang F, Chen W, Wang J, Zhang Y
Bioactive materials 2026 Apr;58:486-504
Bioactive materials 2026 Apr;58:486-504
An intelligent nanoliposome alleviates disc degeneration and discogenic pain by inhibiting neurovascular ingrowth via a "Soil-conditioning, seed-modulating, and weeds-suppressing" strategy.
Li F, Shi Y, Liu J, Yang Y, Yan C, Sun X, Zhang Z, Zhang B, Wang Q, Du M, Wang Z, Sun J, Xu X, Sun K, Sun J, Wang Y, Shi J
Bioactive materials 2026 Apr;58:157-182
Bioactive materials 2026 Apr;58:157-182
Therapeutic effects of hypoxia-preconditioned cartilage progenitor cell-exosomes on osteoarthritis through autophagy activation and macrophage polarization modulation.
Zhou P, Liu X, Li L, Du Y, Liu J, Deng X, Chen Z, Chen S, Li Z, Li Z, He Y
Materials today. Bio 2026 Apr;37:102961
Materials today. Bio 2026 Apr;37:102961
An engineered triple-network alginate/gelatin hydrogel mediates osteochondral regeneration through temporal regulation of the PI3K-AKT pathway.
Zhu Y, Leng P, Liang W, Xu W, Liang H, Yang Y, Si X, Liu X, Yang X, Shi C, Liu M
International journal of biological macromolecules 2026 Apr;358:151622
International journal of biological macromolecules 2026 Apr;358:151622
Osteocyte-Intrinsic MMP13 exacerbates injury-induced temporomandibular joint osteoarthritis.
Yee CS, Demirdji M, Bailey KN, Larios AD, Meliadis C, Luna CA, Taylor HB, Angel PM, Kapila S, Alliston T
Osteoarthritis and cartilage 2026 Apr;34(4):575-588
Osteoarthritis and cartilage 2026 Apr;34(4):575-588
Hsa_circ_0101645 contributes to excessive autophagy and apoptosis in intervertebral disc degeneration by acting as a miR-1304-5p sponge modulating BNIP3 expression.
Luo J, Yu T, Hu P, Liu J
Non-coding RNA research 2026 Apr;17:76-89
Non-coding RNA research 2026 Apr;17:76-89
Pyrroloquinoline quinone alleviates age-related osteoarthritis via nuclear factor erythroid 2-related factor 2-mediated stress response and insulin-like growth factor 1 receptor upregulation.
Xue Q, Gu Y, Qin R, Chen Z, Li J, Li M, Li Y, Li C, Gao W, Liu B, Yang R
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:157996
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:157996
Targeting adipocyte ESRRA alleviates osteoarthritis via interrupting inter-organelle crosstalk of complement C3-CFD-MAC cascade.
Huang T, Wang Z, Gao L, Gao J, Lu Z, Li P, Choy CH, Yuan Z, Zhong Y, Geng CA, Wang H, Yeung KWK, Li B, Pan H, Chen D, Guan M
Bone research 2026 Apr 29;14(1)
Bone research 2026 Apr 29;14(1)
Identification of Autophagy-related Genes of the Osteoarthritis Using Machine Learning Algorithm.
Zhang Z, Wang H, Cheng X, Zhang Z, Hou Z, Liu Z, Gao Y
Biochemical genetics 2026 Apr 21;
Biochemical genetics 2026 Apr 21;
Piezo2 Mediates a Vicious Cycle of "Mechanical Homeostasis Imbalance-Inflammation" in Sensory Nerves and the Cartilage Endplate.
Xu H, Geng W, Du Z, Du Y, Wu D, Tong B, Liang H, Zhou X, Ou Z, Wei J, Wang K, Song Y, Hua W, Xu Y, Ke W, Wang B, Yang C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr 16;:e07299
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr 16;:e07299
A Pathological Microenvironment-Responsive Catalytic Carbon Nanodots Release Platform Intercepting the ROS-Inflammation Cascade to Alleviate Intervertebral Disc Degeneration.
Luo X, Xie J, Yan F, Peng Z, Pan C, Hu Y, Zhang J, Cai C, Yuan J, Li Y, Miao X, He D, Cheng X
Advanced healthcare materials 2026 Apr 14;:e71151
Advanced healthcare materials 2026 Apr 14;:e71151
HDAC6 exacerbates osteoarthritis by promoting macrophage inflammation-mediated chondrocyte degeneration.
Wang S, Fu L, Qiu W, Ouyang J, Song D, Song Z, Zhu Y, Yan Z, Jin F, Lu YJ, Liu G
International immunopharmacology 2026 Apr 1;174:116399
International immunopharmacology 2026 Apr 1;174:116399
Decoding Endoplasmic Reticulum Stress on Chondrocyte Driving Osteoarthritis Development through Integrating Single-Cell and Transcriptomic Profiling.
Zhang Z, Cheng D, Dang J, Wang X, Fan H, Liu D
International journal of medical sciences 2025;22(15):3906-3923
International journal of medical sciences 2025;22(15):3906-3923
Identification of the key role of IL-17RB in the treatment of osteoarthritis with Shaoyao Gancao decoction: Verification based on RNA-seq and bioinformatics analysis.
Hou C, Yu Z, Song Q, Chu X, Wei G, Zhu J, Yang L, Zhao Y, Zhang P, Li Q
PloS one 2025;20(2):e0315913
PloS one 2025;20(2):e0315913
Stigmasterol alleviates endplate chondrocyte degeneration through inducing mitophagy by enhancing PINK1 mRNA acetylation via the ESR1/NAT10 axis.
Li H, Chen X, Huang B, He J, Xie J, Guo W, Liang J, Ruan J, Liu J, Xiang Z, Zhu L
Open life sciences 2025;20(1):20220913
Open life sciences 2025;20(1):20220913
Microfluidic Synthesis of miR-200c-3p Lipid Nanoparticles: Targeting ZEB2 to Alleviate Chondrocyte Damage in Osteoarthritis.
Zheng D, Chen T, Yang K, Yin G, Chen Y, Gui J, Xu C, Lv S
International journal of nanomedicine 2025;20:505-521
International journal of nanomedicine 2025;20:505-521
Adipose Tissue-Derived Exosome Maintains Metabolic Balance of Extracellular Matrix in Rat Nucleus Pulposus Cells.
Zhao R, Ma L, Li J, Liu S, Yang D, Liu G, Yang S
International journal of nanomedicine 2025;20:2411-2425
International journal of nanomedicine 2025;20:2411-2425
Enhancing Cartilage Repair in Osteoarthritis Using Platelet Lysates and Arthroscopic Microfracture.
Zhang H, Li D, Zheng W, Hua J, Chen Z, Xu W, Zhu J, Wang Y, Chen X, Chen H, Guo L, Yuan Q, Zhou L, Shan L
Drug design, development and therapy 2025;19:3827-3843
Drug design, development and therapy 2025;19:3827-3843
Comparison of passive and active motion: effect of myokine irisin on cartilage in knee osteoarthritis rats.
Duan Z, Gao H, Xiao X, He B
Frontiers in physiology 2025;16:1639174
Frontiers in physiology 2025;16:1639174
Passive hydrotherapy preserves cartilage and muscle integrity in a murine osteoarthritis model: potential role of integrin αV/TGF-β mechanotransduction.
Di W, Songyang W, Ruibing F, Yong H, Hao H, Xiaofeng D, Yang R, Yunxiang D, Gang W
Frontiers in physiology 2025;16:1633618
Frontiers in physiology 2025;16:1633618
IL-19 suppresses Hippo signaling via modulating YAP1 phosphorylation in osteoarthritis.
Deng J, Gu J, Gong X, Tang H, Cai Y, Yang Y, Dong S, Zhao C
Frontiers in immunology 2025;16:1630253
Frontiers in immunology 2025;16:1630253
Paeonol ameliorates ferroptosis and inflammation in chondrocytes through AMPK/Nrf2/GPX4 pathway.
Gong S, Lang S, Jiang X, Li X
Frontiers in pharmacology 2025;16:1526623
Frontiers in pharmacology 2025;16:1526623
Bone remodeling stimulated by Wnt-mediated mitophagy regulated extracellular vesicles in subchondral bone contributes to osteoarthritis development.
Gu Y, Zhou Q, Sheng S, Yang H, Huang D, Zhang Q, Zhang H, Cao Z, Zhang Y, Li Z, Jiang Y, Chen X, Jing Y, Wang C, Tan H, Xu K, Su J
Theranostics 2025;15(18):10007-10027
Theranostics 2025;15(18):10007-10027
A strategy targeting ferroptosis for mitochondrial reprogramming and intervertebral disc degeneration therapy.
Wu T, Teng Y, Song D, Yang Y, Shen H, Sun X, Chen R, Zhao L, Zhong X, Yan Q, Niu J, Ge J, Cheng L, Zou J
Theranostics 2025;15(17):9159-9178
Theranostics 2025;15(17):9159-9178
GLSP mitigates vascular aging by promoting Sirt7-mediated Keap1 deacetylation and Keap1-Nrf2 dissociation.
Cheng Y, Zheng G, Huang H, Ni J, Zhao Y, Sun Y, Chang Y, Liu S, He F, Li D, Guo Y, Miao Y, Xu M, Wang D, Zhang Y, Hua Y, Yang S, Fan G, Ma C
Theranostics 2025;15(10):4345-4367
Theranostics 2025;15(10):4345-4367
Lysyl Oxidase-Like 1 (LOXL1) Up-Regulation in Chondrocytes Promotes M1 Macrophage Activation in Osteoarthritis via NF-κB and STAT3 Signaling.
Jiang Y, Wang S, Zhu W, Liu X, Yang Y, Huo L, Ye J, Ma Y, Zhou Y, Yang Z, Mao J, Wang X
ImmunoTargets and therapy 2025;14:259-278
ImmunoTargets and therapy 2025;14:259-278
Hypoxia, cuproptosis, and osteoarthritis: Unraveling the molecular crosstalk.
Jiang Z, Li J, Shi M, Li Y, Sun N, Xi K, Li X, Zhao D, Leng X, Zhou Z, Dong H
Redox biology 2025 Sep;85:103757
Redox biology 2025 Sep;85:103757
TRPM2-mediated feed-forward loop promotes chondrocyte damage in osteoarthritis via calcium-cGAS-STING-NF-κB pathway.
Sun K, Zhang X, Hou L, Lu F, Liu H, Zheng Z, Guo Z, Xu J, Ruan Z, Hou Y, He J, Guo F, Yang K
Journal of advanced research 2025 Sep;75:213-227
Journal of advanced research 2025 Sep;75:213-227
Oxidative stress activates YAP/TEAD1/NCOA4 axis to promote ferroptosis of endplate chondrocytes and aggravate intervertebral disc degeneration.
Wang H, Liu X, Jing X, Zhang B, Liu X, Liu X, Jia F, Su C, Wang W, Cui X
Journal of orthopaedic translation 2025 Sep;54:8-25
Journal of orthopaedic translation 2025 Sep;54:8-25
Primary cilia in growth plates orchestrate long bone development.
Zhang L, Xu X, Tao D, Li X, Niu P, Gong X, Li G, Yu M, Sun Y
Fundamental research 2025 Sep;5(5):2368-2381
Fundamental research 2025 Sep;5(5):2368-2381
Targeted Blockage of Pathological Extracellular Vesicles and Particles From Fibroblast-Like Synoviocytes for Osteoarthritis Relief: Proteomic Analysis and Cellular Effect.
Liu B, Xian Y, Shen T, Ben Y, Wu W, Shi Y, An X, Peng R, Gao W, Gong W, Chen X, Guo B, Jiang Q
Journal of extracellular vesicles 2025 Sep;14(9):e70162
Journal of extracellular vesicles 2025 Sep;14(9):e70162
Tryptophan metabolic dysregulation drives immune activation and cartilage degradation in osteoarthritis: Functional validation integrated with transcriptomic and single-cell RNA sequencing.
Hou W, Chang Y, Zheng Z, Liang H
Biochemical and biophysical research communications 2025 Sep 30;782:152497
Biochemical and biophysical research communications 2025 Sep 30;782:152497
BRD-K20733377 inhibits ferroptosis and alleviates intervertebral disc degeneration via the STAT3/NFKB1 axis: a multiapproach study.
Sun H, You X, Li Z, Li Z, Hua B, Liu C, Zhang Y, Wu H, Zai S, Zhang L
Stem cell research & therapy 2025 Sep 29;16(1):531
Stem cell research & therapy 2025 Sep 29;16(1):531
IRS2/FOXO1 mitigates osteoarthritis by regulating chondrocyte autophagy and mitochondrial function.
Qin C, Chen K, Sun Y, Wang C, Yu Y, Zhu H, Zou G
Molecular medicine (Cambridge, Mass.) 2025 Sep 26;31(1):293
Molecular medicine (Cambridge, Mass.) 2025 Sep 26;31(1):293
Circular RNA-based protein replacement therapy mitigates osteoarthritis in male mice.
Suo J, Li L, Tan W, Yin X, Wang J, Shao R, Sun S, Guo SK, Feng J, Gao BQ, Wang Y, Wei MY, Wang L, Feng H, Gao X, Hu P, Zheng X, Chen LL, Lei G, Huang Y, Zou W
Nature communications 2025 Sep 26;16(1):8480
Nature communications 2025 Sep 26;16(1):8480
Duhuo jisheng decoction alleviates osteoarthritis progression by mitigating ferroptosis in chondrocytes via the nuclear factor erythroid 2-related factor 2/glutathione peroxidase 4 axis.
Wu B, Yang Z, Duan J, Chen Z, Xiao J, Luo Z, Jian G, Wang H, Lu G
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120441
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120441
Enhanced disc regeneration through CRISPR/Cas9-mediated SOX9 and TGFβ1 coexpression in tonsil-derived mesenchymal stromal cells.
Lee S, Yu Y, Kim DH, Bock M, Kim Y, An SB, Choi H, Shin HE, Hwang DY, Han I
Stem cell research & therapy 2025 Sep 25;16(1):501
Stem cell research & therapy 2025 Sep 25;16(1):501
Comparison of the therapeutic efficacy of leukocyte-poor and leukocyte-rich platelet-rich plasma in rabbit knee osteoarthritis and the study of autophagy mechanism.
Sun L, Wang Y, Zhang K, Chen X, Shi H
BMC musculoskeletal disorders 2025 Sep 24;26(1):857
BMC musculoskeletal disorders 2025 Sep 24;26(1):857
Paeoniflorin mitigates iron overload-induced osteoarthritis by suppressing chondrocyte ferroptosis via the p53/SLC7A11/GPX4 pathway.
Wu B, Luo Z, Chen Z, Lu Y, Duan J, Yang Z, Lu G
International immunopharmacology 2025 Sep 23;162:115111
International immunopharmacology 2025 Sep 23;162:115111
A hydrogel-based drug delivery system reduces inflammation and oxidative stress to alleviate intervertebral disc degeneration.
Wang S, Zhai Y, Liu M, Cheng Z, Zhang J, Zhang H, Wang H, Hu Y, Li C, Luo Z
Acta biomaterialia 2025 Sep 1;203:229-244
Acta biomaterialia 2025 Sep 1;203:229-244
Sodium tanshinone IIA sulfonate alleviates osteoarthritis through targeting SIRT1.
Xu M, Sun X, Ma X, Qin Z, Gao X, Jin X, Sun H
Chinese medicine 2025 Sep 1;20(1):142
Chinese medicine 2025 Sep 1;20(1):142
cZFP609 Tethering BiP Alleviates Cartilage Degradation in Osteoarthritis via Remedying Aberrant ER-Mitochondrial Contacts.
Song Y, Luo JL, Zhang F, Shi J, Du S, Jiang HB, Zhang WD, Chen SY, Zhang DD, Kong P, Gao Y, Han M, Li H
MedComm 2025 Oct;6(10):e70405
MedComm 2025 Oct;6(10):e70405
Seeds-and-soil inspired hydrogel microspheres: A dual-action antioxidant and cellular therapy for reversing intervertebral disc degeneration.
Yang Y, Guo J, Cao H, Tian X, Shen H, Niu J, Yang H, Shi Q, Xu Y
Biomaterials 2025 Oct;321:123326
Biomaterials 2025 Oct;321:123326
Magnoflorine ameliorates cartilage degradation in osteoarthritis through inhibition of mitochondrial reactive oxygen species-mediated activation of the NLRP3 inflammasome.
Peng Y, Huang YH, Luo X, Li MC, Xiao QQ, Qiu L, Fu Q
Journal of Asian natural products research 2025 Oct;27(10):1528-1549
Journal of Asian natural products research 2025 Oct;27(10):1528-1549
Duhuo Jisheng decoction alleviates intervertebral disc degeneration by inhibiting nucleus pulposus cell ferroptosis via the exosome-mediated miR-19b-3p/ACSL4 axis.
Feng J, Miao H, Xiao Z, Xu L, Wang Y, Cao X, Wang J, Wu Z, Xia P, Liu W
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Oct;146:157113
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Oct;146:157113
Rabbits as preclinical animal models of cam morphology: proof of concept.
Li Z, Wan P, Liu X, Jiang G, Li J, Chen D, Zhang W, Tian K
BMC musculoskeletal disorders 2025 Oct 6;26(1):918
BMC musculoskeletal disorders 2025 Oct 6;26(1):918
Therapeutic effects of Bushen Chushi formula on knee osteoarthritis via modulation of MAPK/SLC7A11/GPX4 signaling in rats.
Li Y, Tang H, He M, Wang X, Chen Y, Liu S, Zhang H
Hereditas 2025 Oct 29;162(1):220
Hereditas 2025 Oct 29;162(1):220
Genotype and phenotype correlation analysis in 27 families with multiple osteochondroma and validation by ATDC5 chondrocyte models.
Guo X, Lin M, Xu S, Liu B, Zhang R, Liu S, Pan Y
Bone & joint research 2025 Oct 27;14(10):901-914
Bone & joint research 2025 Oct 27;14(10):901-914
Paeonol reduces IL-1β induced apoptosis and degeneration by regulating MAPK pathway in nucleus pulposus cells.
Yu C, Wei X, Wang J, Wang L, Wang J
Biochemical and biophysical research communications 2025 Oct 20;785:152687
Biochemical and biophysical research communications 2025 Oct 20;785:152687
Galangin Alleviates Intervertebral Disc Degeneration via the Nrf2/NF-κB Pathway.
Chen L, Ying S, Guo Z, Tan H, Jin Y, Wang X, Sun J, Zhang X, Zhou C, Chen D, Jiang Y, Peng K
Journal of agricultural and food chemistry 2025 Oct 15;73(41):26060-26072
Journal of agricultural and food chemistry 2025 Oct 15;73(41):26060-26072
Cytosolic phospholipase A2 as a therapeutic target for degenerative joint diseases.
Huang G, He C, Fu W, Bi J, Wang J, Wiznia DH, Liu CJ
Bone research 2025 Oct 15;13(1):86
Bone research 2025 Oct 15;13(1):86
Conjoint analysis of single-cell sequencing and high-throughput virtual screening regarding DDR2 in osteoarthritis disease models.
Mei H, Wang J, Zheng X, Yan R, Li W, Wang P, Wang X, Liu L
European journal of medical research 2025 Oct 10;30(1):954
European journal of medical research 2025 Oct 10;30(1):954
CORM-3 mitigates osteoarthritis by anti-inflammation and enhancing autophagy via inhibiting MAPK and mTOR pathways.
Li J, Zeng Y, Wang S, Chen X, Huang H, Gan X, Kang H
International immunopharmacology 2025 Oct 10;163:115296
International immunopharmacology 2025 Oct 10;163:115296
Circular RNA PVT1 promotes osteoarthritis progression through the miR-550a-3p/CX3CR1 pathway: A mechanistic study.
Liu X, Li G, Yang L, Pan N, Tang S, Yu C, Zhang Q, Zeng L, Goswami A, Deng K, Liao X, Tian Y, Wu Y
International immunopharmacology 2025 Oct 10;163:115272
International immunopharmacology 2025 Oct 10;163:115272
Upregulation of ACSL1 in synovial macrophages promotes lipid peroxidation via the IκB/NF-κB pathway to accelerate osteoarthritis.
Yao Z, Yuan Z, Li Y, Li X, Peng C, Jin J, Zhang H, Bai X, Pan J, Cai D
Journal of orthopaedic translation 2025 Nov;55:360-375
Journal of orthopaedic translation 2025 Nov;55:360-375
Cuproptosis in osteoarthritis: Exploring chondrocyte cuproptosis and therapeutic avenues.
Hua H, Cheng F, Meng Z, Zhang A, Li M, Zhang M, Lou P, Zhu Y, Tong P, Zhang Y
Journal of orthopaedic translation 2025 Nov;55:293-308
Journal of orthopaedic translation 2025 Nov;55:293-308
An aptamer specifically targeting mCRP ameliorates experimental arthritis.
Wang Z, Xie D, Zhu P, Guo J, Cao C, Du Y, Lu A, Liang C
Journal of orthopaedic translation 2025 Nov;55:228-244
Journal of orthopaedic translation 2025 Nov;55:228-244
Investigate the Regulatory Role of Parathyroid Hormone on Condylar Fibrocartilage Homeostasis.
Zhan Y, Shi Z, Yang X, Cao P, Yu H, Wang P, Zhu S, Bi R
Oral diseases 2025 Nov;31(11):3089-3102
Oral diseases 2025 Nov;31(11):3089-3102
Blocking Fpr3 ameliorates osteoarthritis by inhibiting NLRP3-mediated chondrocyte pyroptosis.
Zhou B, Huang Y
Cytokine 2025 Nov;195:157020
Cytokine 2025 Nov;195:157020
High-intensity running exercise promotes knee meniscal damage via the PI3K/AKT/mTOR axis.
Yao J, Ke H, Huang G, Wang X, Li Z, Shao Y, Chen H, Pan J, Cai D, Zeng C
Bone & joint research 2025 Nov 7;14(11):969-983
Bone & joint research 2025 Nov 7;14(11):969-983
KLF5 aggravates osteoarthritis progression by inhibiting chondrocyte autophagy via transcriptional activation of PLK2.
Wang B, Zhang H, Fan Z, Shi H, Huang F, Zhang H
Scientific reports 2025 Nov 6;15(1):38963
Scientific reports 2025 Nov 6;15(1):38963
Lineage plasticity and signal dysregulation define the cellular trajectory of osteoarthritis progression.
Chen G, Tai K, Dai G
Clinical and experimental medicine 2025 Nov 25;26(1):41
Clinical and experimental medicine 2025 Nov 25;26(1):41
FoxO1/PINK1/Parkin-dependent mitophagy mediates the chondroprotective effect of Guzhi Zengsheng Zhitong decoction in osteoarthritis.
Bocheng L, Yongfu C, Junjie C, Ziqi L, Lina G, Tingli Q, Li T, Qian Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157322
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157322
Targeting ICAM1 through LIF-mediated NF-κB/JAK2-STAT3 crosstalk protects nucleus pulposus from IL-1β-driven pyroptosis to ameliorate intervertebral disc degeneration.
Wang Z, Liu J, Xu H, Sun Y, Xu S, He X
Journal of orthopaedic surgery and research 2025 Nov 22;20(1):1096
Journal of orthopaedic surgery and research 2025 Nov 22;20(1):1096
Targeting the ROS-ferroptosis-inflammation cycle with a nanozyme-functionalized hydrogel for intervertebral disc repair.
Wang Y, Tan L, Yang Y, Duan H, Liu C, Zhao J, Zhou Y, Li C, Liu M
Nature communications 2025 Nov 20;16(1):11253
Nature communications 2025 Nov 20;16(1):11253
The Effect of Platelet-Rich Plasma on Synovial Fibrosis and Cartilage Degeneration in Knee Osteoarthritis.
Zhang JY, Xiang XN, Wang Q, Wang XX, Guan AJ, He CQ, Yu X, He HC
The American journal of sports medicine 2025 May;53(6):1428-1439
The American journal of sports medicine 2025 May;53(6):1428-1439
SHP2-mediated ROS activation induces chondrocyte paraptosis in osteoarthritis and is attenuated by low-intensity pulsed ultrasound.
Hou W, Shang X, Hao X, Pan C, Zheng Z, Zhang Y, Deng X, Chi R, Liu J, Guo F, Sun K, Xu T
Journal of orthopaedic translation 2025 May;52:233-248
Journal of orthopaedic translation 2025 May;52:233-248
Cohesin Complex Interacting with Promoters of MMP Genes for in Pterygium Occurrence.
Han S, Zhu W, Guo Q
Current eye research 2025 May;50(5):467-476
Current eye research 2025 May;50(5):467-476
UGDH Lactylation Aggravates Osteoarthritis by Suppressing Glycosaminoglycan Synthesis and Orchestrating Nucleocytoplasmic Transport to Activate MAPK Signaling.
Lan W, Chen X, Yu H, Ruan J, Kang J, Nie X, Cao Y, Tang S, Ding C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(20):e2413709
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(20):e2413709
Cell-Free Fat Extract for the Treatment of Lumbar Disc Degeneration: A Novel Approach Using Adipose-Derived Biologic.
Xu C, Zhou X, Yang C, Zhou F, Xie Y
Biomedicines 2025 May 30;13(6)
Biomedicines 2025 May 30;13(6)
Dihydrotestosterone and 17β-estradiol modulate TMJ osteoarthritis development and reveal sex-specific differences in pathogenesis.
Tomura T, Ishii T, Kasahara N, Nishii Y
Scientific reports 2025 May 28;15(1):18740
Scientific reports 2025 May 28;15(1):18740
NOXA exacerbates endoplasmic-reticulum-stress-induced intervertebral disc degeneration by activating apoptosis and ECM degradation.
Liu Z, Lu H, Zhang X, Tang S, Lin A, Han S, Ma X
Cell death discovery 2025 May 28;11(1):257
Cell death discovery 2025 May 28;11(1):257
Osteocyte-derived extracellular vesicles mediate the bone-to-cartilage crosstalk and promote osteoarthritis progression.
Liu N, Ma Y, Gong W, Shao X, Shi T, Li L, Wu W, Chen X, Shi Y, Zhang P, Lin J, Wang C, Fang D, Yang L, Wang P, Gao W, He Y, An X, Du R, Chen Y, Liu B, Qin J, Chen D, Cai P, Jiang Q, Guo B
Nature communications 2025 May 22;16(1):4746
Nature communications 2025 May 22;16(1):4746
Nicotinamide Adenine Dinucleotide-Loaded Lubricated Hydrogel Microspheres with a Three-Pronged Approach Alleviate Age-Related Osteoarthritis.
Lin Y, Wu H, Wang J, He W, Hou J, Martin VT, Zhu C, Chen Y, Zhong J, Yu B, Lu A, Guan D, Qin G, Chen W
ACS nano 2025 May 13;19(18):17606-17626
ACS nano 2025 May 13;19(18):17606-17626
Streamlined metal-based hydrogel facilitates stem cell differentiation, extracellular matrix homeostasis and cartilage repair in male rats.
Li W, Shi Z, Jing H, Dou Y, Liu X, Zhang M, Qiu Z, Heger Z, Li N
Nature communications 2025 May 10;16(1):4344
Nature communications 2025 May 10;16(1):4344
Blockade of the vaspin-AP-1 axis inhibits arthritis development.
Jeon J, Cho C, Kim S, Kim H, Lee H, Kim SJ, Park H, Yu JH, Lee S, Lee KS, Jung J, Yang S
Experimental & molecular medicine 2025 Mar;57(3):628-636
Experimental & molecular medicine 2025 Mar;57(3):628-636
Sustained therapeutic effects of self-assembled hyaluronic acid nanoparticles loaded with α-Ketoglutarate in various osteoarthritis stages.
Wang X, Xue Y, Hao K, Peng B, Chen H, Liu H, Wang J, Cao J, Dong W, Zhang S, Yang Q, Li J, Lei W, Feng Y
Biomaterials 2025 Mar;314:122845
Biomaterials 2025 Mar;314:122845
Synergistic therapeutic effect of parecoxib and ilomastat combination in osteoarthritis via inhibition of IL-17/PI3K/AKT/NF-κB activity.
Feng X, Ma Y, Zhao Y, Zhao Z, Song Z, Lin L, Wang W
Molecular immunology 2025 Mar;179:94-105
Molecular immunology 2025 Mar;179:94-105
Piezo1 promotes intervertebral disc degeneration through the Ca(2+)/F-actin/Yap signaling axis.
Peng F, Sun M, Jing X, Chen F, Cao T, Li Z, Li T
Molecular medicine (Cambridge, Mass.) 2025 Mar 8;31(1):90
Molecular medicine (Cambridge, Mass.) 2025 Mar 8;31(1):90
Alleviation of inflammation in paraventricular nucleus and sympathetic outflow by melatonin efficiently repairs endplate porosities and attenuates spinal hyperalgesia.
Yan M, Lv X, Zhang S, Song Z, Hu B, Qing X, Kou H, Chen S, Shao Z, Liu H
International immunopharmacology 2025 Mar 6;149:114213
International immunopharmacology 2025 Mar 6;149:114213
circ_0000389 inhibits intervertebral disc degeneration by targeting the miR-346/KLF7 axis.
Liu C, Yu C, Duan Y, Li J, Chen X, Xu W, Qiu S
Acta biochimica et biophysica Sinica 2025 Mar 5;57(10):1636-1646
Acta biochimica et biophysica Sinica 2025 Mar 5;57(10):1636-1646
Selective promotion of sensory innervation-mediated immunoregulation for tissue repair.
Xu K, Wu K, Chen L, Zhao Y, Li H, Lin N, Ye Z, Xu J, Huang D, Huang X
Science advances 2025 Mar 21;11(12):eads9581
Science advances 2025 Mar 21;11(12):eads9581
Low intensity pulsed ultrasound alleviates synovial fibrosis in osteoarthritis via the PI3K/AKT pathway.
Liao Q, Chen J, Liu G
Scientific reports 2025 Mar 20;15(1):9644
Scientific reports 2025 Mar 20;15(1):9644
Targeting Txnip-mediated metabolic reprogramming has therapeutic potential for osteoarthritis.
Cao X, Yang X, Zhang P, Xu J, Zhao J, Yang E
Cell death discovery 2025 Mar 20;11(1):110
Cell death discovery 2025 Mar 20;11(1):110
Orientin alleviates chondrocyte senescence and osteoarthritis by inhibiting PI3K/AKT pathway.
Chen H, Liu S, Xing J, Wen Y, Chen L
Bone & joint research 2025 Mar 14;14(3):245-258
Bone & joint research 2025 Mar 14;14(3):245-258
LATS1-modulated ZBTB20 perturbing cartilage matrix homeostasis contributes to early-stage osteoarthritis.
Hao X, Zhao J, Jia L, Ding G, Liang X, Su F, Yang S, Yang Y, Fan J, Zhang WJ, Yang L, Jie Q
Bone research 2025 Mar 12;13(1):33
Bone research 2025 Mar 12;13(1):33
A bladder-blood immune barrier constituted by suburothelial perivascular macrophages restrains uropathogen dissemination.
Li L, Jiao Q, Yang Q, Lu H, Zhou X, Zhang Q, Zhang F, Li H, Tian Z, Zeng Z
Immunity 2025 Mar 11;58(3):568-584.e6
Immunity 2025 Mar 11;58(3):568-584.e6
Gastrodin Alleviates Lumbar Intervertebral Disc Degeneration by Suppressing the NF-κB and MAPK Pathways.
Hu H, Xie T
Cell biochemistry and biophysics 2025 Jun;83(2):2009-2021
Cell biochemistry and biophysics 2025 Jun;83(2):2009-2021
Naringin in repairing articular cartilage injury by activating TGF-β/Smad signaling pathway to attenuate inflammatory response.
Lyu T, Liu X, Liu Y, Yang Z, Li P, Lu Y, Zhao P, Chen J, Ye C
Archives of biochemistry and biophysics 2025 Jun;768:110396
Archives of biochemistry and biophysics 2025 Jun;768:110396
GM@mTG-V microspheres promote NP regeneration by reconstructing IVD biomechanics and inflammatory microenvironment.
Gao R, Zhang Y, Deng B, Zhang J, Liang Z, Wei Z, Xu F, Ding T
Materials today. Bio 2025 Jun;32:101897
Materials today. Bio 2025 Jun;32:101897
Membrane biomimetic nanoenzyme-incorporated hybrid glycyrrhizic acid hydrogel for precise mitochondrial ROS scavenging for osteoarthritis treatment.
Fan Y, Niu Z, Yin L, Yao L, Ding S, Tong Y, Wang J, Hong Z, Chen J, Zhang Q, Ji L, Chen J, Xia C, Bi Q
Materials today. Bio 2025 Jun;32:101778
Materials today. Bio 2025 Jun;32:101778
Vaccarin ameliorates osteoarthritis by suppressing the c-Jun N-terminal kinase (JNK)-serum amyloid A2 (SAA2) pathway mediating chondrocyte senescence.
Gan X, Li J, Jiang Y, Wang X, Zeng Y, Chen X, Huang H, Min J, Li G, Nie M, Kang H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156697
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156697
CIP2A promotes inflammation and exacerbates osteoarthritis by targeting CEMIP.
Su J, Sun X, Chen X, Wei K, Luo D, Yang S, Zhang C, Xu J, Deng Z
Cellular & molecular biology letters 2025 Jun 9;30(1):67
Cellular & molecular biology letters 2025 Jun 9;30(1):67
Role and mechanism of lncRNA ZEB1-AS1 endogenous competition for miR-365a-3p targeting NRF2 in ferroptosis in articular chondrocytes.
Zhang R, Liu Y, Zang H, He A, Mao Y, Liu W
Journal of molecular histology 2025 Jun 7;56(3):190
Journal of molecular histology 2025 Jun 7;56(3):190
Unveiling the mechanisms of mechanical loading-induced knee osteoarthritis through transcriptomics.
Wu Y, Li A, Sun N, Jiang Z, Li Y, Zhou Z, Li X, Zhao D, Leng X, Dong H
International immunopharmacology 2025 Jun 5;157:114785
International immunopharmacology 2025 Jun 5;157:114785
Berberine alleviates tendinopathy by suppressing the cGAS-STING pathway and Relieving ferroptosis.
Shen Y, Wei W, Lu Y, Song M, Yang S, Liu H, Xu X, Zhou H
Biochemical and biophysical research communications 2025 Jun 30;767:151923
Biochemical and biophysical research communications 2025 Jun 30;767:151923
Exosomal miR-574-3p from adipose-derived mesenchymal stem modulates CRIM1/BMPs signaling to restrain chondrocytes hypertrophy and inflammatory response in knee osteoarthritis.
Kang J, Zhang L, Zhang L, Nan N, Liu Y, Hao H
International immunopharmacology 2025 Jun 26;159:114916
International immunopharmacology 2025 Jun 26;159:114916
Ginsenoside Rh1 attenuates chondrocyte senescence and osteoarthritis via AMPK/PINK1/Parkin-mediated mitophagy.
Chen H, Zhao D, Liu S, Zhong Y, Wen Y, Chen L
International immunopharmacology 2025 Jun 26;159:114911
International immunopharmacology 2025 Jun 26;159:114911
Merlin controls limb development and thumb formation by regulating primary cilium-hedgehog signaling.
Wu S, Bian Y, Zhang C, Liu K, Sun F, Chen E, Zhou C, Yu L, Chen G, Wu M
Cell reports 2025 Jun 24;44(6):115849
Cell reports 2025 Jun 24;44(6):115849
RTA 408 attenuates TBHP-Induced apoptosis in nucleus pulposus cells via Nrf2/ARE and NF-κB signaling pathways: in vitro and in vivo evidence for mitigating rats' intervertebral disc degeneration.
Chen W, Li D, Chen L, Fei J, Bian M, Zeng Q, Jiang Z, Wu J
Arthritis research & therapy 2025 Jun 19;27(1):128
Arthritis research & therapy 2025 Jun 19;27(1):128
Modulating systemic anti-inflammatory response mitigates osteoarthritis progression and associated pain after low-dose radiotherapy.
Ma G, Yang Y, Li S, Li L, Meng X, Rong Y, Tang M, Cheng Q, Guo H, Li Q, Jin X
International immunopharmacology 2025 Jun 17;158:114815
International immunopharmacology 2025 Jun 17;158:114815
Injection of human umbilical cord mesenchymal stem cells exosomes for the treatment of knee osteoarthritis: from preclinical to clinical research.
Wang Y, Kong Y, Du J, Qi L, Liu M, Xie S, Hao J, Li M, Cao S, Cui H, Liu A, Ma J, Song Y
Journal of translational medicine 2025 Jun 11;23(1):641
Journal of translational medicine 2025 Jun 11;23(1):641
Verification of Pain-Related Neuromodulation Mechanisms of Calcitonin in Knee Osteoarthritis.
Lin Q, Tan X, Ma D, Huang Y, Wang L, Zheng D, Lin J, Zhu Z, Mao M, Yi Z, Wang J, Li X
Molecular neurobiology 2025 Jul;62(7):8341-8358
Molecular neurobiology 2025 Jul;62(7):8341-8358
Micro-Focused Ultrasound Technology for Remodeling of Skin Tissue Architecture in an Animal Model.
Tang H, Li Y, Xiang X, Li W, Wang H, Hamblin MR, Wen X
Lasers in surgery and medicine 2025 Jul;57(5):439-449
Lasers in surgery and medicine 2025 Jul;57(5):439-449
Senkyunolide I prevent chondrocytes from oxidative stress through Nrf2/HO-1 signaling pathway.
Li P, Tang W, Wen H, Zhou S, Cao H
Naunyn-Schmiedeberg's archives of pharmacology 2025 Jul;398(7):8335-8344
Naunyn-Schmiedeberg's archives of pharmacology 2025 Jul;398(7):8335-8344
Spatiotemporally Programming Microenvironment to Recapitulate Endochondral Ossification via Greenhouse-Inspired Bionic Niche.
Liu X, Zhao Y, Wu X, Zhou Y, Liu Y, Wang S, Zhang Y, Yang H, Song F, Huang C
Advanced materials (Deerfield Beach, Fla.) 2025 Jul;37(28):e2504057
Advanced materials (Deerfield Beach, Fla.) 2025 Jul;37(28):e2504057
Crosstalk between ferroptosis and NLRP3, a possible therapeutic target in experimentally-induced rheumatoid arthritis: role of P2Y12R inhibition in modulating P53/SLC7A11/ALOX15 signaling.
Eltyar FS, El-Tanbouly DM, Zaki HF, El-Sayed RM
Inflammopharmacology 2025 Jul;33(7):3947-3967
Inflammopharmacology 2025 Jul;33(7):3947-3967
Blocking the LRH-1/LCN2 axis by ML-180, an LRH-1 inverse agonist, ameliorates osteoarthritis via inhibiting the MAPK pathway.
Li J, Zhang Y, Gan X, Li J, Xia G, He L, Xia C, Zhang W, Akhtar Ali K, Zhu M, Huang H
Biochemical pharmacology 2025 Jul;237:116922
Biochemical pharmacology 2025 Jul;237:116922
Inhibition of Heat Shock Protein 90β by Catalpol: A Potential Therapeutic Approach for Alleviating Inflammation-Induced Cartilage Injuries in Osteoarthritis.
Zhou Z, Zhang B, Liu L, Yang J, Wang Y, Lv C, Zhang H, Wei Y, Jiang Z, Peng Z, Zhao D, Leng X, Li X, Su H, Dong H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(26):e2503909
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(26):e2503909
Liposome-encapsulated AICAR hydrogel regulates macrophage metabolic reprogramming via SIK1 activation to alleviate osteoarthritis.
Fu Y, Hou J, Yang Q, Lin Y, Rui N, Wang J, Wu H, Yu B
Journal of nanobiotechnology 2025 Jul 5;23(1):486
Journal of nanobiotechnology 2025 Jul 5;23(1):486
CircZNF418 alleviates oxidative stress-induced cartilage endplate degeneration by stabilizing Sox9 through HuR.
Du Q, Xue J, Fan D, Chen J, Zhong G, Chen J
Journal of molecular histology 2025 Jul 31;56(4):242
Journal of molecular histology 2025 Jul 31;56(4):242
Adipose Mesenchymal Stem Cells Derived Exosomes Ameliorates KOA Cartilage Damage and Inflammation by Activation of PINK1-Mediated Mitochondrial Autophagy.
Kang J, Jie L, Fu H, Zhang L, Lu G, Yu L, Tian D, Liao T, Yin S, Xin R, Wang P
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jul 31;39(14):e70811
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jul 31;39(14):e70811
Periplocin targets LRP4 to regulate metabolic homeostasis and anti-inflammation for the treatment of IVDD.
Liu Z, Qiao F, Liu D, Kong X, Liu K, Gu H, Zhang Y, Meng Q, Cheng L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156885
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156885
Genetically engineered chondrocyte-mimetic nanoplatform attenuates osteoarthritis by blocking IL-1β and restoring sirtuin-3.
Deng C, Yu L, Zhao X, Chen Y, Mei J, Wei J, Chen X, Lei G, Zeng C
Science advances 2025 Jul 25;11(30):eadv4238
Science advances 2025 Jul 25;11(30):eadv4238
Antler base (Cervus nippon Temminck) peptides modulate the NLRP3 inflammatory pyroptosis and Nrf2/HO-1/NQO1 signaling pathways to ameliorate osteoarthritis: a structural and mechanistic study.
Sun S, Qiu H, Wang C, Zhang K, Zhao H, Zhao H, Shen Y, Wang Y, Zhang Y
Journal of ethnopharmacology 2025 Jul 24;351:120149
Journal of ethnopharmacology 2025 Jul 24;351:120149
Systematic pharmacology and experimental validation revealed the mechanism of Bupleurum chinense DC -mediated autophagy in alleviating osteoarthritis.
Wang Y, Wang C, Zhu Y, Chen K, Yu Y, Li R, Huang S, Tao T, Jiang Y
Journal of ethnopharmacology 2025 Jul 24;351:120042
Journal of ethnopharmacology 2025 Jul 24;351:120042
FK506 contributes to peripheral nerve regeneration by inhibiting neuroinflammatory responses and promoting neuron survival.
Kou Y, Jin Z, Yuan Y, Ma B, Xie W, Han N
Neural regeneration research 2025 Jul 1;20(7):2108-2115
Neural regeneration research 2025 Jul 1;20(7):2108-2115
Defective RuO(2) Nanospheres Attenuate Osteoarthritis Progression via Suppressing the ROS/NLRP3/Caspase-1 Signaling Pathway.
Lv J, Muhammad F, Wang Z, Qiao C, Gu X, Liu Y, Li W, Gong W, Lv Z, Fei Y, Peng L, Lu Z, Xu N, Hu C, Zhang H, Wu R, Xu X, Wei H, Sun Z, Shi D
ACS nano 2025 Jul 1;19(25):23080-23095
ACS nano 2025 Jul 1;19(25):23080-23095
MicroRNA‑4327 regulates TGF‑β1 stimulation of matrix metalloproteinase‑13 expression via CREB‑binding protein‑mediated Runx2 acetylation in human osteoblasts.
Kolipaka R, Magesh I, Karthik S, Ashok Bharathy MR, Saranya I, Preetha D, Selvamurugan N
Experimental and therapeutic medicine 2025 Jan;29(1):20
Experimental and therapeutic medicine 2025 Jan;29(1):20
Protective role of Yougui Yin in experimental knee osteoarthritis: From the perspective of macrophage polarization.
Wu Z, Xu K, Chen M, Wang S, Ma Y
Prostaglandins & other lipid mediators 2025 Jan;176:106940
Prostaglandins & other lipid mediators 2025 Jan;176:106940
The antiarthritic effect of CBR-470-1 in hypoxic environment is to increase the level of NOD-like receptor family pyrin domain containing 3 ubiquitination by decreasing phosphoglycerate kinase 1 activity.
Duan A, Ma Z, Shao X, Xiong Z, Zhang C, Liu W, Wang G, Hu S, Lin W
Clinical and translational medicine 2025 Jan;15(1):e70118
Clinical and translational medicine 2025 Jan;15(1):e70118
Cell-free osteoarthritis treatment with dual-engineered chondrocyte-targeted extracellular vesicles derived from mechanical loading primed mesenchymal stem cells.
Wang P, Zhao H, Chen W, Guo Y, Zhang S, Xing X, Yang S, Wang F, Wang J, Shao Z, Zhang Y
Journal of tissue engineering 2025 Jan-Dec;16:20417314241312563
Journal of tissue engineering 2025 Jan-Dec;16:20417314241312563
EZH2/miR-142-3p/HMGB1 axis mediates chondrocyte pyroptosis by regulating endoplasmic reticulum stress in knee osteoarthritis.
Chen Y, Dong S, Zeng X, Xu Q, Liang M, Liao G, Li L, Shen B, Lu Y, Si H
Chinese medical journal 2025 Jan 5;138(1):79-92
Chinese medical journal 2025 Jan 5;138(1):79-92
Characterization of a chemically induced osteoarthritis model in zebrafish.
Xiao G, Qin J, Yang H, Song Q, Zhang R, Huang J, Mou Y, Liu W, Sun X, Nie M
Scientific reports 2025 Jan 31;15(1):3905
Scientific reports 2025 Jan 31;15(1):3905
Enhanced Chondrogenic Potential and Osteoarthritis Treatment Using Cyaonoside A-Induced MSC Delivered via a Hyaluronic Acid-Based Hydrogel System.
An X, Zhou Q, Sheng S, Deng A, Liu H, Wang X, Zhang Q, Jing Y, Xu K, He C, Zhao RC, Su J
Aging and disease 2025 Jan 29;17(1):466-482
Aging and disease 2025 Jan 29;17(1):466-482
Integrated analysis of bioinformatics, mendelian randomization, and experimental validation reveals novel diagnostic and therapeutic targets for osteoarthritis: progesterone as a potential therapeutic agent.
Weng Z, Wang C, Liu B, Yang Y, Zhang Y, Zhang C
Journal of orthopaedic surgery and research 2025 Jan 23;20(1):85
Journal of orthopaedic surgery and research 2025 Jan 23;20(1):85
Tree shrew as a new animal model for musculoskeletal disorders and aging.
Wei X, Li H, Qiu J, Jiao J, Guo X, Yin G, Yang P, Han Y, Zhao Q, Zeng H, Rao Z, Gao X, Li K, Lai P, Zhang S, Yang C, Lu D, Bai X
Bone research 2025 Jan 2;13(1):5
Bone research 2025 Jan 2;13(1):5
Marein ameliorates the progression of osteoarthritis: An in vitro and in vivo studies.
Yin L, He Z, Fan Y, Niu Z, Yao L, Ding S, Chen J, Zhang Q, Tong Y, Bi Q, Cao L
International immunopharmacology 2025 Jan 10;144:113695
International immunopharmacology 2025 Jan 10;144:113695
RICTOR-mediated activation of AKT/mTOR signaling and autophagy inhibition promote osteoarthritis.
Xu J, Wang G, Hou Y, Sun K, Zheng Z, Guo Z, Hou L, Zhang X, Ruan Z, Ye Y, Guo F
International immunopharmacology 2025 Jan 10;144:113681
International immunopharmacology 2025 Jan 10;144:113681
Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Loaded Mir-29-3p Targets AhR to Improve Juvenile Idiopathic Arthritis via Inhibiting the Expression of IL-22 in CD4(+) T Cell.
Wei X, Sui K, Peng Y, Li S, Fang Y, Chen Z, Du X, Xie X, Tang H, Wen Q, Li J, He M, Cheng Q, Zhang W
Stem cell reviews and reports 2025 Feb;21(2):536-553
Stem cell reviews and reports 2025 Feb;21(2):536-553
Blocking the CCL5/CCL7-CCR1 axis regulates macrophage polarization through NF-κB pathway to alleviate the progression of osteoarthritis.
Xu H, He Y, Chen S, Meng C, Liu Q, Huang XJ, You HB
International immunopharmacology 2025 Feb 6;147:114027
International immunopharmacology 2025 Feb 6;147:114027
Ferristatin II protects nucleus pulposus against degeneration through inhibiting ferroptosis and activating HIF-1α pathway mediated mitophagy.
Su C, Jing X, Liu X, Shao Y, Zheng Y, Liu X, Cui X
International immunopharmacology 2025 Feb 6;147:113895
International immunopharmacology 2025 Feb 6;147:113895
kexB Gene Correlates With Aspergillus flavus Keratitis Severity: A Whole-Genome Analysis.
Liu J, Kang M, Wei Y, Zhang Z, Pang J, Chen Q, Xu X, Wei Z, Zhang Y, Chen K, Wang Z, Lu X, Liang Q
Investigative ophthalmology & visual science 2025 Feb 3;66(2):42
Investigative ophthalmology & visual science 2025 Feb 3;66(2):42
Revolutionizing the treatment of intervertebral disc degeneration: an approach based on molecular typing.
Chen S, Zhang W, Liu Y, Huang R, Zhou X, Wei X
Journal of translational medicine 2025 Feb 25;23(1):227
Journal of translational medicine 2025 Feb 25;23(1):227
Matrix stiffness regulates nucleus pulposus cell glycolysis by MRTF-A-dependent mechanotransduction.
Xu H, Wei K, Ni J, Deng X, Wang Y, Xiang T, Song F, Wang Q, Niu Y, Jiang F, Wang J, Sheng L, Dai J
Bone research 2025 Feb 14;13(1):23
Bone research 2025 Feb 14;13(1):23
Yanghe decoction alleviates osteoarthritis by AMPK-SIRT3 positive feedback loop-mediated mitochondrial autophagy.
Shi PB, Du MM, Yu P, Bu XZ, Meng DF, Qiao WP, Wang LH, Li HY
Journal of ethnopharmacology 2025 Feb 11;341:119294
Journal of ethnopharmacology 2025 Feb 11;341:119294
Delivery of FBXO6 with highly branched poly(β-amino ester)s to modulate the inflammatory environment for the treatment of osteoarthritis.
Shi Y, Shen S, Huang D, Yilamu K, Chen Z, Wang K, Chen P, Pan N, Jin Z, Guo L, Xu W, Zhao X
Journal of controlled release : official journal of the Controlled Release Society 2025 Feb 10;378:294-305
Journal of controlled release : official journal of the Controlled Release Society 2025 Feb 10;378:294-305
An Ex Vivo Model of Intervertebral Disc Degeneration for Assessing Retention of Injectable Cell-Based Grafts.
Schmid R, Apte J, Schulze E, Sirek A, Schäfer G, Schäper J, Santini F, Negoias S, Barbero A, Martin I, Pelttari K, Schären S, Krupkova O, Mehrkens A
JOR spine 2025 Dec;8(4):e70144
JOR spine 2025 Dec;8(4):e70144
Experimental study on the role and biomarker potential of CX3CR1 in osteoarthritis.
Huang J, Zheng X, Meng J, Wang H, Chen L, Yao J
Annals of medicine 2025 Dec;57(1):2529577
Annals of medicine 2025 Dec;57(1):2529577
Bioenergetic-active hydrogel drives extracellular matrix synthesis for cartilage repair.
Jiang S, Lan Z, Zhang X, Liu X, Xu J, Chen Y, Li J, Chen C, Liu D, Chen M, Wang J, Du Y, Zhang S
Bioactive materials 2025 Dec;54:34-46
Bioactive materials 2025 Dec;54:34-46
Calcified Cartilage Zone Remodeling Induced by IL-1β Derived from Necrotic Subchondral Bone Initiates Cartilage Degeneration in Patients with Glucocorticoids-induced Osteonecrosis of the Femoral Head.
Wang P, Shen L, Yang R, Wang X, Wang X, Zhu Y, Liu R
Inflammation 2025 Dec;48(6):4126-4142
Inflammation 2025 Dec;48(6):4126-4142
Integrating superlubricative nanomaterials with precision drug delivery for advanced osteoarthritis therapy.
Gan X, Li J, Li S, Wang X, Wang Q, Chen X, Huang Y, Nie M, Kang H, Dai H
Materials today. Bio 2025 Dec;35:102359
Materials today. Bio 2025 Dec;35:102359
Bottom-up engineering of the nucleus pulposus using a photocrosslinkable decellularized matrix hydrogel attenuates inflammaging and enhances microtissue-mediated regeneration.
Li X, Li X, Zhou D, Xu Y, Sun B, Hu Y, Zhu Y, Hu J, Pang Z, Zhao C, Gao Y, Long Y, Li P, Zhou Q, Wang Y
Materials today. Bio 2025 Dec;35:102347
Materials today. Bio 2025 Dec;35:102347
Circadian rhythm disturbance induces osteoarthritis in mice: Involvement of Clock and Bmal1 dysregulation and Pdgfa inhibition.
Guo A, Zheng K, Jia W, Zhang S, Sui C
Biochemical pharmacology 2025 Dec;242(Pt 3):117342
Biochemical pharmacology 2025 Dec;242(Pt 3):117342
Dysfunctional autophagy triggers STING1 activation to exacerbate cartilage degeneration in obesity-associated osteoarthritis.
Kang X, Liu W, Ma X, Feng D, Sun H, Wu S
Autophagy 2025 Dec;21(12):3344-3360
Autophagy 2025 Dec;21(12):3344-3360
HSF1 Increases EOGT-Mediated Glycosylation of Notch1 to Promote IL-1β-Induced Inflammatory Injury of Chondrocytes.
Huang Y, Pan W, Bao H, Sun X, Xu C, Ma J
Cartilage 2025 Dec;16(4):486-494
Cartilage 2025 Dec;16(4):486-494
Microenvironment-Responsive Injectable Microspheres for Osteoarthritis Treatment via Oxidative Stress Inhibition and Sustained Lubrication.
Yu Z, Liu Y, Xiao R, Li R, Song J, Chen B, Liao L
Advanced healthcare materials 2025 Dec;14(32):e02637
Advanced healthcare materials 2025 Dec;14(32):e02637
TLR4-IN-C34 attenuates the progression of osteoarthritis through inhibiting inflammation, angiogenesis and pain.
Wei K, Zou Y, Xu H, Liu H, Liu C
Cellular signalling 2025 Dec;136:112084
Cellular signalling 2025 Dec;136:112084
Partial meniscus allograft transplantation preserving the recipient's anterior root: a comparative study in a rabbit model.
Tan H, Qin H, Chen Y, Wang E, Zhou A, Lian C, Zhang H
European journal of medical research 2025 Dec 26;31(1):160
European journal of medical research 2025 Dec 26;31(1):160
Photobiomodulation mitigates chondrocyte catabolism in osteoarthritis by modulating macrophage M1 polarization through the IL-6/JAK/STAT pathway.
Wang H, Ning W, Liu Y, Nie J, Du S, Zhang H
Journal of orthopaedic surgery and research 2025 Dec 24;20(1):1082
Journal of orthopaedic surgery and research 2025 Dec 24;20(1):1082
Hydrogels Derived from Native Decellularized Perichondrium for Chondrocyte Differentiation and Temporomandibular Joint Repair.
Zhou G, Yee MJ, Huh JT, Safina I, Chang WS, Koch A, Embree MC
ACS applied materials & interfaces 2025 Dec 24;17(51):69150-69161
ACS applied materials & interfaces 2025 Dec 24;17(51):69150-69161
RNF152-mediated, ubiquitin-dependent degradation of HSP27 activates the PI3K/AKT pathway, driving synovial inflammatory cascades in TMJOA.
Zhang X, Jiang Q, Deng W, Tang H, Liu Y, Xu Z, Guo K, Liu N, Wang H, Cui T, Wang F, Qiu J
Arthritis research & therapy 2025 Dec 18;28(1):16
Arthritis research & therapy 2025 Dec 18;28(1):16
Denosumab attenuates knee osteoarthritis progression by inhibiting synovial inflammation via the RANK/TRAF6/FSTL1 signalling.
Hu Y, Chen W, Lan S, Ming C, Xu D, Li H, Xu H, Shi D, Liu W, Dai Z, Wang J, He Z, Xu W, Shao Z, Liu Y, Tian H, Tong W
Nature communications 2025 Dec 17;16(1):11394
Nature communications 2025 Dec 17;16(1):11394
Panaxatriol exerts anti-senescence effects and alleviates osteoarthritis and cartilage repair fibrosis by targeting UFL1.
Kuang B, Geng N, Yi M, Zeng Q, Fan M, Xian M, Deng L, Chen C, Pan Y, Kuang L, Luo F, Xie Y, Liu C, Deng Z, Nie M, Du Y, Guo F
Journal of advanced research 2025 Aug;74:493-511
Journal of advanced research 2025 Aug;74:493-511
WSTF nuclear autophagy regulates chronic but not acute inflammation.
Wang Y, Eapen VV, Liang Y, Kournoutis A, Sherman MS, Xu Y, Onorati A, Li X, Zhou X, Corey KE, Du K, Cabral Burkard AM, Ho CK, Xie J, Zhang H, Maeso-Díaz R, Ma X, Rieprecht U, O'Brien T, Cetinbas M, Wang L, Liu J, Bretz C, Havas AP, Zhou Z, Ho Sui SJ, Saladi SV, Sadreyev RI, Adams PD, Kingston RE, Diehl AM, Alman B, Goessling W, Yue Z, Wang XF, Johansen T, Dou Z
Nature 2025 Aug;644(8077):780-789
Nature 2025 Aug;644(8077):780-789
Microneedle Radiofrequency Induces Extracellular Matrix Remodeling Through Fibroblast Activation: A Histological Study in a Porcine Model.
Xu Y, Zhang Y, Wang H, Tang H, Zeng W, Wen X
Lasers in surgery and medicine 2025 Aug;57(6):528-543
Lasers in surgery and medicine 2025 Aug;57(6):528-543
Schistosoma japonicum-Derived Peptide SJMHE1 Attenuates Osteoarthritis by Promoting Synovial M2 Macrophage Polarisation.
Zhu W, Jiang Y, Wang S, Wang X, Zhang Q, Fan W
Parasite immunology 2025 Aug;47(8):e70018
Parasite immunology 2025 Aug;47(8):e70018
Pterostilbene Improves Apoptosis, Inflammation, and Autophagy of Osteoarthritis Chondrocytes Through the Ras/Raf/MEK/ERK Pathway.
Zhou L, Sun CC, Shen FJ, Yuan YF, Sun QL, Rui Z
Journal of biochemical and molecular toxicology 2025 Aug;39(8):e70407
Journal of biochemical and molecular toxicology 2025 Aug;39(8):e70407
Dual-functional ROS-responsive hydrogel alleviates temporomandibular joint osteoarthritis by enhancing cartilage repair and mitigating inflammation.
Kuang Y, Hua B, Ye X, Zhao Y, Yu M, Liu X
Materials today. Bio 2025 Aug;33:102103
Materials today. Bio 2025 Aug;33:102103
Deliver CEBPE via cartilage targeting Lipid nanoparticle to block CEBPE-LTF-STAT3 positive feedback loop for efficient treatment of cartilage endplate degeneration.
Zhao J, Xu P, Li T, Yuan J, Zhao W, Ding R, Yang G, Xie J, Huang G, Peng Z, Miao X, Cheng X
Materials today. Bio 2025 Aug;33:102027
Materials today. Bio 2025 Aug;33:102027
Zn(2+)-driven metformin conjugated with siRNA attenuates osteoarthritis progression by inhibiting NF-κB signaling and activating autophagy.
He H, Huang C, Huang H, Lan N, Liu S, Luo Y, Zheng L, Liu G, Qin Z, Zhao J
Biomaterials 2025 Aug;319:123210
Biomaterials 2025 Aug;319:123210
The Mechanosensitive Ion Channel Piezo1 Regulates Chondrocyte Homeostasis Through the PI3K/AKT/mTORC1 Pathway in Osteoarthritis.
Han Y, Cheng F, Li X, Yu J, Li G, Chen W, Zhang J, Feng C, Zhang Y, Wang J
Journal of cellular and molecular medicine 2025 Aug;29(15):e70734
Journal of cellular and molecular medicine 2025 Aug;29(15):e70734
Biomimetic Nanoplatform Integrating CeO₂ Nanozymes and Anti-Inflammatory Peptides for Osteoarthritis Therapy.
Yang C, Liao X, Wang Y, Zhong W, Xian F, Gao M, Zeng M, Chen J, Chen X, Li M, Zhou K
Small (Weinheim an der Bergstrasse, Germany) 2025 Aug;21(32):e2502677
Small (Weinheim an der Bergstrasse, Germany) 2025 Aug;21(32):e2502677
USP5-Rich Apoptotic Extracellular Vesicles Regulate Nucleus Pulposus Cells Apoptosis and DNA Damage Repair by Preventing E2F1 Proteasomal Degradation.
Shi P, Gao H, Cheng Z, Wu W, Zhang A, Chen X, Wu W, Zhang Y
Journal of extracellular vesicles 2025 Aug;14(8):e70148
Journal of extracellular vesicles 2025 Aug;14(8):e70148
β-Mangostin Attenuates TET2-Mediated DNA Demethylation of Prkcg in the Prevention of Intervertebral Disc Degeneration.
Kong X, Gu H, Zhang Y, Meng Q, Li Q, Song K, Li Y, Liu K, Liu Z, Hu R, Zhai H, Li T, Ling Z, Wei Z, Wei F, Cheng L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(32):e05077
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(32):e05077
Eosinophils-Induced Lumican Secretion by Synovial Fibroblasts Alleviates Cartilage Degradation via the TGF-β Pathway Mediated by Anxa1 Binding.
Chen W, Zhou Y, Yuan W, Ou Y, Lin H, He K, Qian X, Chen H, Wang C, Lu J, Chen W, Li D, Chen J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(29):e2416030
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(29):e2416030
DNA Origami-Based CD44-Targeted Therapy Silences Stat3 Enhances Cartilage Regeneration and Alleviates Osteoarthritis Progression.
Lv Q, Zhao X, Teng S, Jin X, Zhou Y, Sun Y, Pei H, Yan Z, Ma C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(29):e03939
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(29):e03939
A sonoelectric niche for noninvasive intervertebral disc regeneration via targeted cell cycle modulation.
Zhang X, Liang H, Liao Z, Tong B, Wu D, Ma L, Lei J, Zhou X, Zhu D, Ou Z, Wei J, Tan L, Yang C
Science advances 2025 Aug 8;11(32):eadu6860
Science advances 2025 Aug 8;11(32):eadu6860
Matrix Stiffening-Induced SLIT3 Activation in Chondrocytes Drives Cartilage Degradation and Angiogenesis in Temporomandibular Joint Osteoarthritis.
Chen Y, Yuan W, Wang Y, Liu W, Shi J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Aug 31;39(16):e70936
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Aug 31;39(16):e70936
Moxibustion ameliorates abnormal subchondral bone remodeling by promoting ACSL1-mediated autophagy to degrade NLRP3 in osteoarthritis.
Chen X, Fu L, Huang Y, Liao Q, Zou B, Yuan L, Liu G
Chinese medicine 2025 Aug 11;20(1):125
Chinese medicine 2025 Aug 11;20(1):125
Targeting MLKL ameliorates T-2 toxin-induced cartilage damage by inhibiting chondrocyte death and matrix degradation in mice.
Zhang M, Zhao X, Liu Y, Liu Y, Shi Y, Zhang Y, Chen J
Archives of toxicology 2025 Apr;99(4):1505-1516
Archives of toxicology 2025 Apr;99(4):1505-1516
The miR-6779/XIAP axis alleviates IL-1β-induced chondrocyte senescence and extracellular matrix loss in osteoarthritis.
Li Z, Dai A, Fang X, Tang K, Chen K, Gao P, Su J, Chen X, Yang S, Deng Z, Li L
Animal models and experimental medicine 2025 Apr;8(4):662-673
Animal models and experimental medicine 2025 Apr;8(4):662-673
Synergizing adaptive immunity and regenerative signals to enhance osteochondral defects repair.
Lin C, Ying C, Xu Y, Zou Y, Chen R, Xu K, Ji X, Cao Q, Weng J, Jiang L, Ye C, Xu K, He Y, Li W, Wu L, Ran J, Xiong Y, Yu X, Bao J
Bioactive materials 2025 Apr;46:242-258
Bioactive materials 2025 Apr;46:242-258
Total glucosides of white paeony capsule alleviate articular cartilage degeneration and aberrant subchondral bone remodeling in knee osteoarthritis.
Liao T, Kang J, Ma Z, Jie L, Feng M, Liu D, Mao J, Wang P, Xing R
Phytotherapy research : PTR 2025 Apr;39(4):1758-1775
Phytotherapy research : PTR 2025 Apr;39(4):1758-1775
sLithospermic acid etched ZIF-8 nanoparticles delays osteoarthritis progression by inhibiting inflammatory signaling pathways and rescuing mitochondrial damage.
Zhang Y, Lou Q, Lian H, Yang R, Cui R, Wang L, Ma B, Hou L, Jin L, Teng W
Materials today. Bio 2025 Apr;31:101589
Materials today. Bio 2025 Apr;31:101589
Cerium Dioxide Nanoparticles-Based Inspector Enhances Mitochondrial Quality Control to Maintain Chondrocyte Homeostasis in Osteoarthritis Therapy.
Chen L, Yang J, Cai Z, Huang Y, Zhang Q, Zhou C, Wang J, Huang W, Cui W, Hu N
Advanced healthcare materials 2025 Apr;14(10):e2405069
Advanced healthcare materials 2025 Apr;14(10):e2405069
β-Diketone Functionalized Microspheres Chelate Reactive Iron via Metal Coordination for Cartilage Repair.
Xu Y, Gu X, Li X, Chen Y, Wei Z, Wang J, Liu Y, Ji Y, Cheng Q, Jiang S, Yu J, Li X, Cui W, Ye X
Advanced healthcare materials 2025 Apr;14(10):e2403933
Advanced healthcare materials 2025 Apr;14(10):e2403933
Palmatine activation of TFEB enhances autophagy and alleviates endoplasmic reticulum stress in intervertebral disc degeneration.
Yu H, Chen K, Li X, Liang J, Jin Y, Bao Y, Chen H, Gou Y, Lu K, Wu L, Lin Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156431
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156431
Regulatory effect and mechanism of CircSEC24A in IL-1β-induced osteoarthritis.
Wang Y, Chen X, Chen Y, Sun Q, Wang H
Archives of physiology and biochemistry 2025 Apr;131(2):188-198
Archives of physiology and biochemistry 2025 Apr;131(2):188-198
LIPUS Promotes Calcium Oscillation and Enhances Calcium Dependent Autophagy of Chondrocytes to Alleviate Osteoarthritis.
Guan M, Han X, Liao B, Han W, Chen L, Zhang B, Peng X, Tian Y, Xiao G, Li X, Kuang L, Zhu Y, Bai D
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(16):e2413930
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(16):e2413930
S-propargyl-cysteine attenuates temporomandibular joint osteoarthritis by regulating macrophage polarization via Inhibition of JAK/STAT signaling.
Cai W, Wu A, Lin Z, Cao W, Pathak JL, Jaspers RT, Li R, Li X, Zheng K, Lin Y, Zhou N, Zhang X, Zhu Y, Zhang Q
Molecular medicine (Cambridge, Mass.) 2025 Apr 7;31(1):128
Molecular medicine (Cambridge, Mass.) 2025 Apr 7;31(1):128
Lacc1-engineered extracellular vesicles reprogram mitochondrial metabolism to alleviate inflammation and cartilage degeneration in TMJ osteoarthritis.
Hu X, Xie J, Su J
Journal of nanobiotechnology 2025 Apr 5;23(1):276
Journal of nanobiotechnology 2025 Apr 5;23(1):276
Notopterol mitigates osteoarthritis progression and relieves pain in mice by inhibiting PI3K/Akt/GPX4-mediated ferroptosis.
Zhou X, Pan Y, Li J, Zhuang R, Tong P, Xia H
International immunopharmacology 2025 Apr 4;151:114323
International immunopharmacology 2025 Apr 4;151:114323
RNA-binding protein HuR interacts with UFM1 mRNA to ameliorate chondrocyte inflammation, apoptosis and extracellular matrix degradation.
Li L, Zhou R, Yue Z, Li H, Han Y, Zhang L, Zhu J
Functional & integrative genomics 2025 Apr 28;25(1):95
Functional & integrative genomics 2025 Apr 28;25(1):95
LGR6 modulates intervertebral disc degeneration through regulation of macrophage efferocytosis.
Li F, Shi Y, Chen J, Sun J, Shi J, Sun K, Zheng B
Journal of translational medicine 2025 Apr 25;23(1):475
Journal of translational medicine 2025 Apr 25;23(1):475
FAM20B-Catalyzed Glycosylation Regulates the Chondrogenic and Osteogenic Differentiation of the Embryonic Condyle by Controlling IHH Diffusion and Release.
Chen X, Liu H, Huang Y, Li L, Jiang X, Liu B, Li N, Zhu L, Liu C, Xiao J
International journal of molecular sciences 2025 Apr 24;26(9)
International journal of molecular sciences 2025 Apr 24;26(9)
LncRNA EMBP1 sponges miR-454-3p to upregulate IRF1 and activate NLRP3-mediated chondrocyte pyroptosis to drive osteoarthritis progression.
Ma S, Yu P, Ma J, Liu K, Wang M, Shi P, Duong NTD, Cheng S, Wang S
International immunopharmacology 2025 Apr 24;153:114460
International immunopharmacology 2025 Apr 24;153:114460
Impact of Escherichia coli and Lipopolysaccharide on the MAPK Signaling Pathway, MMPs, TIMPs, and the uPA System in Bovine Mammary Epithelial Cells.
Zhang Y, Ding Y, Liang J, Zhang K, Su H, Wang D, Zhang M, Zhao F, Sun Z, Wu Z, Wang F, Cao G, Zhang Y
International journal of molecular sciences 2025 Apr 20;26(8)
International journal of molecular sciences 2025 Apr 20;26(8)
Platelet-rich plasma ameliorates cartilage degradation in rat models of osteoarthritis via the OPG/RANKL/RANK system.
Wu Q, Yao X, Shan N, Cai Y, Fan Y
Folia histochemica et cytobiologica 2024;62(3):154-164
Folia histochemica et cytobiologica 2024;62(3):154-164
M2 Macrophage-Derived Small Extracellular Vesicles Ameliorate Pyroptosis and Intervertebral Disc Degeneration.
Zhang K, Du L, Li Z, Huo Z, Shen L, Gao S, Jia Y, Zhu M, Xu B
Biomaterials research 2024;28:0047
Biomaterials research 2024;28:0047
CD62E- and ROS-Responsive ETS Improves Cartilage Repair by Inhibiting Endothelial Cell Activation through OPA1-Mediated Mitochondrial Homeostasis.
Tu P, Pan Y, Wang L, Li B, Sun X, Liang Z, Liu M, Zhao Z, Wu C, Wang J, Wang Z, Song Y, Zhang Y, Ma Y, Guo Y
Biomaterials research 2024;28:0006
Biomaterials research 2024;28:0006
The role and underlying mechanism of dental pulp stem cell-derived exosomal miR-31 in the treatment of osteoarthritis by targeting mTOR to enhance chondrocyte autophagy levels.
Zhao G, Lyu J, Huang X, Huang G, Chen F, Wei Y, Wang S, Xia J, Chen J, Shi J
Archives of medical science : AMS 2024;20(5):1680-1694
Archives of medical science : AMS 2024;20(5):1680-1694
The Therapeutic Potential of Pristimerin in Osteoarthritis: Mechanistic Insights from in vitro and in vivo Studies.
Yin L, Fan Y, Zhong X, Meng X, He Z, Hong Z, Chen J, Zhang Q, Kong M, Wang J, Tong Y, Bi Q
Drug design, development and therapy 2024;18:5445-5459
Drug design, development and therapy 2024;18:5445-5459
Systematic Pharmacology and Experimental Validation to Reveal the Alleviation of Astragalus membranaceus Regulating Ferroptosis in Osteoarthritis.
Chen K, Yu Y, Wang Y, Zhu Y, Qin C, Xu J, Zou X, Tao T, Li Y, Jiang Y
Drug design, development and therapy 2024;18:259-275
Drug design, development and therapy 2024;18:259-275
"Dictionary of immune responses" reveals the critical role of monocytes and the core target IRF7 in intervertebral disc degeneration.
Xu P, Li K, Yuan J, Zhao J, Pan H, Pan C, Xiong W, Tan J, Li T, Huang G, Chen X, Miao X, He D, Cheng X
Frontiers in immunology 2024;15:1465126
Frontiers in immunology 2024;15:1465126
Spermidine attenuates chondrocyte inflammation and cellular pyroptosis through the AhR/NF-κB axis and the NLRP3/caspase-1/GSDMD pathway.
Guo X, Feng X, Yang Y, Zhang H, Bai L
Frontiers in immunology 2024;15:1462777
Frontiers in immunology 2024;15:1462777
Identification of candidate genes and chemicals associated with osteonecrosis of femoral head by multiomics studies and chemical-gene interaction analysis.
Lu X, Wang X, Wang P, Zhu Y, Liu J, Liu G, Liu R
Frontiers in endocrinology 2024;15:1419742
Frontiers in endocrinology 2024;15:1419742
A rabbit osteochondral defect (OCD) model for evaluation of tissue engineered implants on their biosafety and efficacy in osteochondral repair.
Zhou L, Ho KK, Zheng L, Xu J, Chen Z, Ye X, Zou L, Li Y, Chang L, Shao H, Li X, Long J, Nie Y, Stoddart MJ, Lai Y, Qin L
Frontiers in bioengineering and biotechnology 2024;12:1352023
Frontiers in bioengineering and biotechnology 2024;12:1352023
Melatonin Alleviates Osteoarthritis by Regulating NADPH Oxidase 4-Induced Ferroptosis and Mitigating Mitochondrial Dysfunction.
Wang Q, Qi B, Shi S, Jiang W, Li D, Jiang X, Yi C
Journal of pineal research 2024 Sep;76(6):e12992
Journal of pineal research 2024 Sep;76(6):e12992
Memantine attenuates the development of osteoarthritis by blocking NMDA receptor mediated calcium overload and chondrocyte senescence.
Cheng Q, He K, Zhu J, Li X, Wu X, Zeng C, Lei G, Wang N, Li H, Wei J
Journal of orthopaedic translation 2024 Sep;48:204-216
Journal of orthopaedic translation 2024 Sep;48:204-216
Selenium Deficiency Can Promote the Expression of VEGF and Inflammatory Factors in Cartilage Differentiation and Mediates Cartilage Injury.
Meng X, Meng X, He Z, Yuan Y, Fan Y, Yin L, Tong Y, Hong Z, Zhu S, Zhang Q, Bi Q
Biological trace element research 2024 Sep;202(9):4170-4179
Biological trace element research 2024 Sep;202(9):4170-4179
DSCR1-1 attenuates osteoarthritis-associated chondrocyte injury by regulating the CREB1/ALDH2/Wnt/β-catenin axis: An in vitro and in vivo study.
Cao ZM, Fu S, Dong C, Yang TY, Liu XK, Zhang CL, Li DZ
Cellular signalling 2024 Sep;121:111287
Cellular signalling 2024 Sep;121:111287
Suppression of YAP Ameliorates Cartilage Degeneration in Ankle Osteoarthritis via Modulation of the Wnt/β-Catenin Signaling Pathway.
Fan Z, Zhao X, Ma J, Zhan H, Ma X
Calcified tissue international 2024 Sep;115(3):283-297
Calcified tissue international 2024 Sep;115(3):283-297
Hypoxia-Preconditioned BMSC-Derived Exosomes Induce Mitophagy via the BNIP3-ANAX2 Axis to Alleviate Intervertebral Disc Degeneration.
Jin Y, Wu O, Chen Q, Chen L, Zhang Z, Tian H, Zhou H, Zhang K, Gao J, Wang X, Guo Z, Sun J, Kwan KYH, Jones M, Li YM, Zare EN, Makvandi P, Wang X, Shen S, Wu A
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Sep;11(34):e2404275
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Sep;11(34):e2404275
Osteopontin deficiency promotes cartilaginous endplate degeneration by enhancing the NF-κB signaling to recruit macrophages and activate the NLRP3 inflammasome.
Wang Y, Zhang W, Yang Y, Qin J, Wang R, Wang S, Fu W, Niu Q, Wang Y, Li C, Li H, Zhou Y, Liu M
Bone research 2024 Sep 6;12(1):53
Bone research 2024 Sep 6;12(1):53
10-hydroxy-2-decenoic acid prevents osteoarthritis by targeting aspartyl β hydroxylase and inhibiting chondrocyte senescence in male mice preclinically.
Geng N, Fan M, Kuang B, Zhang F, Xian M, Deng L, Chen C, Pan Y, Chen J, Feng N, Liang L, Ye Y, Liu K, Li X, Du Y, Guo F
Nature communications 2024 Sep 4;15(1):7712
Nature communications 2024 Sep 4;15(1):7712
Deferoxamine alleviates chondrocyte senescence and osteoarthritis progression by maintaining iron homeostasis.
Guo Z, Lin Y, Liu H, Guo J, Hou L, Zhang X, Xu J, Ruan Z, Li M, Sun K, Guo F
International immunopharmacology 2024 Sep 30;139:112619
International immunopharmacology 2024 Sep 30;139:112619
Lubricin-Inspired Nanozymes Reconstruct Cartilage Lubrication System with an "In-Out" Strategy.
Du C, Chen Z, Liu S, Liu J, Zhan J, Zou J, Liao J, Huang W, Lei Y
Small methods 2024 Oct;8(10):e2400757
Small methods 2024 Oct;8(10):e2400757
Ellagic acid improves osteoarthritis by inhibiting PGE2 production in M1 macrophages via targeting PTGS2.
Zhang C, Li X, Wen P, Li Y
Clinical and experimental pharmacology & physiology 2024 Oct;51(10):e13918
Clinical and experimental pharmacology & physiology 2024 Oct;51(10):e13918
A novel mesenchymal stem cell-targeting dual-miRNA delivery system based on aptamer-functionalized tetrahedral framework nucleic acids: Application to endogenous regeneration of articular cartilage.
Fu L, Wu J, Li P, Zheng Y, Zhang Z, Yuan X, Ding Z, Ning C, Sui X, Liu S, Shi S, Guo Q, Lin Y
Bioactive materials 2024 Oct;40:634-648
Bioactive materials 2024 Oct;40:634-648
LTF ameliorates cartilage endplate degeneration by suppressing calcification, senescence and matrix degradation through the JAK2/STAT3 pathway.
Li T, Liu Y, Cao J, Pan C, Ding R, Zhao J, Liu J, He D, Jia J, Cheng X
Journal of cellular and molecular medicine 2024 Oct;28(19):e18267
Journal of cellular and molecular medicine 2024 Oct;28(19):e18267
Therapeutic framework nucleic acid complexes targeting oxidative stress and pyroptosis for the treatment of osteoarthritis.
Li J, Li Y, Shang X, Xu S, Zhang Z, Xu S, Wang X, Shen M
Materials today. Bio 2024 Oct;28:101202
Materials today. Bio 2024 Oct;28:101202
Multifunctional human serum albumin-crosslinked and self-assembling nanoparticles for therapy of periodontitis by anti-oxidation, anti-inflammation and osteogenesis.
Cao B, Da X, Wu W, Xie J, Li X, Wang X, Xu H, Gao J, Yang H, Su J
Materials today. Bio 2024 Oct;28:101163
Materials today. Bio 2024 Oct;28:101163
Single-cell RNA sequencing reveals the MIF/ACKR3 receptor-ligand interaction between neutrophils and nucleus pulposus cells in intervertebral disc degeneration.
Zhang TL, Chen WK, Huang XP, Zheng BW, Wu PF, Zheng BY, Jiang LX, Escobar D, Li J, Lv GH, Huang W, Zhou H, Xu Z, Zou MX
Translational research : the journal of laboratory and clinical medicine 2024 Oct;272:1-18
Translational research : the journal of laboratory and clinical medicine 2024 Oct;272:1-18
Collagen denaturation in post-run Achilles tendons and Achilles tendinopathy: In vivo mechanophysiology and magnetic resonance imaging.
Fang Y, Zhu D, Wei J, Qian L, Qiu R, Jia T, Huang K, Zhao S, Ouyang J, Li M, Li S, Li Y
Science advances 2024 Oct 4;10(40):eado2015
Science advances 2024 Oct 4;10(40):eado2015
IRF1-mediated upregulation of PARP12 promotes cartilage degradation by inhibiting PINK1/Parkin dependent mitophagy through ISG15 attenuating ubiquitylation and SUMOylation of MFN1/2.
Deng Z, Long D, Li C, Liu H, Li W, Zhong Y, Mo X, Li R, Yang Z, Kang Y, Mao G
Bone research 2024 Oct 28;12(1):63
Bone research 2024 Oct 28;12(1):63
Exploring the Mechanism of Sempervirine Inhibiting Glioblastoma Invasion Based on Network Pharmacology and Bioinformatics.
Zhang B, Wang W, Song Y, Chen H, Lin X, Chen J, Chen Y, Huang J, Li D, Wu S
Pharmaceuticals (Basel, Switzerland) 2024 Oct 2;17(10)
Pharmaceuticals (Basel, Switzerland) 2024 Oct 2;17(10)
Bioenergetic-active exosomes for cartilage regeneration and homeostasis maintenance.
Liu X, Jiang S, Jiang T, Lan Z, Zhang X, Zhong Z, Wu X, Xu C, Du Y, Zhang S
Science advances 2024 Oct 18;10(42):eadp7872
Science advances 2024 Oct 18;10(42):eadp7872
A RANKL-UCHL1-sCD13 negative feedback loop limits osteoclastogenesis in subchondral bone to prevent osteoarthritis progression.
Liang W, Feng R, Li X, Duan X, Feng S, Chen J, Li Y, Chen J, Liu Z, Wang X, Ruan G, Tang S, Ding C, Huang B, Zou Z, Chen T
Nature communications 2024 Oct 10;15(1):8792
Nature communications 2024 Oct 10;15(1):8792
TDP-43 ameliorates aging-related cartilage degradation through preventing chondrocyte senescence.
Wang L, Zhang J, Liang L, Song Z, Wang P, Ma L, Liao Z, Li N, Yang H, Li S
Experimental gerontology 2024 Oct 1;195:112546
Experimental gerontology 2024 Oct 1;195:112546
Leukemia inhibitory factor protects against experimental periodontitis through immuno-modulations of both macrophages and periodontal ligament fibroblasts.
Ou Y, Fan L, Wang X, Xia H, Cheng M, Huang J, Liang Y, Wang Y, Zhou Y
Journal of periodontology 2024 Nov;95(11):1073-1085
Journal of periodontology 2024 Nov;95(11):1073-1085
β-Hydroxybutyrate enhances chondrocyte mitophagy and reduces cartilage degeneration in osteoarthritis via the HCAR2/AMPK/PINK1/Parkin pathway.
Zhuang H, Ren X, Zhang Y, Li H, Zhou P
Aging cell 2024 Nov;23(11):e14294
Aging cell 2024 Nov;23(11):e14294
Circular RNA KIAA0564 Serves as a Competitive Endogenous RNA for MicroRNA-424-5p, Mediating the Expression of Lysine Demethylase 4a, Thereby Facilitating Intervertebral Disc Degeneration.
Zeng P, Zheng X, Zhang H, Zhou M, Chen Z, Song H, Xu W
Applied biochemistry and biotechnology 2024 Nov;196(11):8134-8155
Applied biochemistry and biotechnology 2024 Nov;196(11):8134-8155
Targeted Therapy of Osteoarthritis via Intra-Articular Delivery of Lipid-Nanoparticle-Encapsulated Recombinant Human FGF18 mRNA.
Sun M, Ma B, Pan Z, Zhao Y, Tian L, Fan Y, Kong W, Wang J, Xu B, Ao Y, Guo Q, Wang X, Peng X, Li X, Cheng J, Miao L, Wang K, Hu X
Advanced healthcare materials 2024 Nov;13(29):e2400804
Advanced healthcare materials 2024 Nov;13(29):e2400804
Anti-Stress and Anti-ROS Effects of MnOx-Functionalized Thermosensitive Nanohydrogel Protect BMSCs for Intervertebral Disc Degeneration Repair.
Wang X, Yu L, Duan J, Chang M, Hao M, Xiang Z, Qiu C, Sun J, Di D, Xia H, Li D, Yuan S, Tian Y, Qiu J, Liu H, Liu X, Sang Y, Wang L
Advanced healthcare materials 2024 Nov;13(29):e2400343
Advanced healthcare materials 2024 Nov;13(29):e2400343
Tetrahedral Framework Nucleic Acid-Based Delivery of Astaxanthin Suppresses Chondrocyte Pyroptosis and Modulates Oxidative Stress for the Treatment of Osteoarthritis.
Li Y, Li J, Xu S, Li D, Zhang Z, Huang Q, Wang X, Shen M, Xu S
Advanced healthcare materials 2024 Nov;13(28):e2401452
Advanced healthcare materials 2024 Nov;13(28):e2401452
RIP1 inhibition reduces chondrocyte apoptosis through downregulating nuclear factor-kappa B signaling in a mouse osteoarthritis model.
Zhao H, Wang C, Liu B, Weng Z, Shi Y, Zhang C
Molecular biology reports 2024 Nov 8;51(1):1132
Molecular biology reports 2024 Nov 8;51(1):1132
Development of a novel HER2-CAR monocyte cell therapy with controllable proliferation and enhanced anti-tumor efficacy.
Yang B, Wang X, Wei X, Ma J
Chinese medical journal 2024 Nov 5;137(21):2590-2602
Chinese medical journal 2024 Nov 5;137(21):2590-2602
Screening and validation of key genes associated with osteoarthritis.
He M, Yu Q, Xiao H, Dong H, Li D, Gu W
BMC musculoskeletal disorders 2024 Nov 25;25(1):954
BMC musculoskeletal disorders 2024 Nov 25;25(1):954
Inhibition of PA28γ expression can alleviate osteoarthritis by inhibiting endoplasmic reticulum stress and promoting STAT3 phosphorylation.
Mo H, Sun K, Hou Y, Ruan Z, He Z, Liu H, Li L, Wang Z, Guo F
Bone & joint research 2024 Nov 20;13(11):659-672
Bone & joint research 2024 Nov 20;13(11):659-672
Proteoglycans Enhance the Therapeutic Effect of BMSC Transplantation on Osteoarthritis.
Ran C, Liu T, Bao Y, Wang W, Xue D, Yin G, Zhang X, Zhao D
Bioengineering (Basel, Switzerland) 2024 Nov 20;11(11)
Bioengineering (Basel, Switzerland) 2024 Nov 20;11(11)
Phillyrin: A potential therapeutic agent for osteoarthritis via modulation of NF-κB and Nrf2 signaling pathways.
Ma J, Wang Z, Sun Y, Zheng R, Tan H, Zhang H, Jin Z, Wu Y, Sun Z
International immunopharmacology 2024 Nov 15;141:112960
International immunopharmacology 2024 Nov 15;141:112960
Protective effects of sugarcane polyphenol against UV-B-induced photoaging in Balb/c mouse skin: Antioxidant, anti-inflammatory, and anti-glycosylation Effects.
Wang J, Wang M, Zhang C, Li W, Zhang T, Zhou Y, Flavel M, Xi Y, Li H, Liu X
Journal of food science 2024 May;89(5):3048-3063
Journal of food science 2024 May;89(5):3048-3063
HIF-2α/TFR1 mediated iron homeostasis disruption aggravates cartilage endplate degeneration through ferroptotic damage and mtDNA release: A new mechanism of intervertebral disc degeneration.
Jing X, Wang W, He X, Liu X, Yang X, Su C, Shao Y, Ge Z, Wang H, Cui X
Journal of orthopaedic translation 2024 May;46:65-78
Journal of orthopaedic translation 2024 May;46:65-78
Histological and immunohistochemical analyses of articular cartilage during onset and progression of pre- and early-stage osteoarthritis in a rodent model.
Takahashi I, Takeda K, Toyama T, Matsuzaki T, Kuroki H, Hoso M
Scientific reports 2024 May 8;14(1):10568
Scientific reports 2024 May 8;14(1):10568
D-mannose alleviates intervertebral disc degeneration through glutamine metabolism.
Dong ZL, Jiao X, Wang ZG, Yuan K, Yang YQ, Wang Y, Li YT, Wang TC, Kan TY, Wang J, Tao HR
Military Medical Research 2024 May 6;11(1):28
Military Medical Research 2024 May 6;11(1):28
Effect of umbilical cord blood-mononuclear cells on knee osteoarthritis in rabbits.
Fu Y, Zhang C, Yang Y, Zhou B, Yang M, Zhu G, Zhu Y
Journal of orthopaedic surgery and research 2024 May 30;19(1):323
Journal of orthopaedic surgery and research 2024 May 30;19(1):323
Genkwanin alleviates intervertebral disc degeneration via regulating ITGA2/PI3K/AKT pathway and inhibiting apoptosis and senescence.
Li M, Yu X, Chen X, Jiang Y, Zeng Y, Ren R, Nie M, Zhang Z, Bao Y, Kang H
International immunopharmacology 2024 May 30;133:112101
International immunopharmacology 2024 May 30;133:112101
IGF2BP2 regulates the inflammation of fibroblast-like synoviocytes via GSTM5 in rheumatoid arthritis.
Nan Y, Chen M, Wu W, Huang R, Sun W, Lu Q, Gu Z, Mao X, Xu H, Wang Y
Cell death discovery 2024 May 3;10(1):215
Cell death discovery 2024 May 3;10(1):215
Machine learning-based identification and immune characterization of ferroptosis-related molecular clusters in osteoarthritis and validation.
Guo X, Feng X, Yang Y, An W, Bai L
Aging 2024 May 29;16(11):9437-9459
Aging 2024 May 29;16(11):9437-9459
Human Umbilical Cord Mesenchymal Stromal Cell-Derived Extracellular Vesicles Induce Fetal Wound Healing Features Revealed by Single-Cell RNA Sequencing.
Liu Y, Zhang M, Wang C, Chen H, Su D, Yang C, Tao Y, Lv X, Zhou Z, Li J, Liao Y, You J, Wang Z, Cheng F, Yang R
ACS nano 2024 May 28;18(21):13696-13713
ACS nano 2024 May 28;18(21):13696-13713
Maslinic acid alleviates intervertebral disc degeneration by inhibiting the PI3K/AKT and NF-κB signaling pathways.
Que Y, Wong C, Qiu J, Gao W, Lin Y, Zhou H, Gao B, Li P, Deng Z, Shi H, Hu W, Liu S, Peng Y, Su P, Xu C, Liang A, Qiu X, Huang D
Acta biochimica et biophysica Sinica 2024 May 25;56(5):776-788
Acta biochimica et biophysica Sinica 2024 May 25;56(5):776-788
Matrix stiffening promotes chondrocyte senescence and the osteoarthritis development through downregulating HDAC3.
Fu B, Shen J, Zou X, Sun N, Zhang Z, Liu Z, Zeng C, Liu H, Huang W
Bone research 2024 May 24;12(1):32
Bone research 2024 May 24;12(1):32
An integrated network pharmacology, molecular docking and experiment validation study to investigate the potential mechanism of Isobavachalcone in the treatment of osteoarthritis.
Fan Y, Yin L, Zhong X, He Z, Meng X, Chai F, Kong M, Zhang Q, Xia C, Tong Y, Bi Q
Journal of ethnopharmacology 2024 May 23;326:117827
Journal of ethnopharmacology 2024 May 23;326:117827
Spinosin ameliorates osteoarthritis through enhancing the Nrf2/HO-1 signaling pathway.
Lu P, Li S, Zhang C, Jiang X, Xiang J, Xu H, Dong J, Wang K, Shi Y
European journal of histochemistry : EJH 2024 May 22;68(2)
European journal of histochemistry : EJH 2024 May 22;68(2)
siRNA incorporated in slow-release injectable hydrogel continuously silences DDIT4 and regulates nucleus pulposus cell pyroptosis through the ROS/TXNIP/NLRP3 axis to alleviate intervertebral disc degeneration.
Ma M, Zhang C, Zhong Z, Wang Y, He X, Zhu D, Qian Z, Yu B, Kang X
Bone & joint research 2024 May 21;13(5):247-260
Bone & joint research 2024 May 21;13(5):247-260
Ginkgolide C inhibits ROS-mediated activation of NLRP3 inflammasome in chondrocytes to ameliorate osteoarthritis.
Jia L, Gong Y, Jiang X, Fan X, Ji Z, Ma T, Li R, Liu F
Journal of ethnopharmacology 2024 May 10;325:117887
Journal of ethnopharmacology 2024 May 10;325:117887
Hnrnpk protects against osteoarthritis through targeting WWC1 mRNA and inhibiting Hippo signaling pathway.
Zhang S, Zhang B, Liao Z, Chen Y, Guo W, Wu J, Liu H, Weng R, Su D, Chen G, Zhang Z, Li C, Long J, Xiao Y, Ma Y, Zhou T, Xu C, Su P
Molecular therapy : the journal of the American Society of Gene Therapy 2024 May 1;32(5):1461-1478
Molecular therapy : the journal of the American Society of Gene Therapy 2024 May 1;32(5):1461-1478
Engineered Exosomes with ATF5-Modified mRNA Loaded in Injectable Thermogels Alleviate Osteoarthritis by Targeting the Mitochondrial Unfolded Protein Response.
Ma T, Xu G, Gao T, Zhao G, Huang G, Shi J, Chen J, Song J, Xia J, Ma X
ACS applied materials & interfaces 2024 May 1;16(17):21383-21399
ACS applied materials & interfaces 2024 May 1;16(17):21383-21399
Circ_ST6GAL1-mediated competing endogenous RNA network regulates TGF-β1-stimulated matrix Metalloproteinase-13 expression via Runx2 acetylation in osteoblasts.
Saranya I, Akshaya RL, Gomathi K, Mohanapriya R, He Z, Partridge NC, Selvamurugan N
Non-coding RNA research 2024 Mar;9(1):153-164
Non-coding RNA research 2024 Mar;9(1):153-164
Dynamics of N6-methyladenosine modification during aging and their potential roles in the degeneration of intervertebral disc.
Liu L, Sun H, Zhang Y, Liu C, Zhuang Y, Liu M, Ai X, Long D, Huang B, Li C, Zhou Y, Dong S, Feng C
JOR spine 2024 Mar;7(1):e1316
JOR spine 2024 Mar;7(1):e1316
Involvement of DJ-1 in the pathogenesis of intervertebral disc degeneration via hexokinase 2-mediated mitophagy.
Lin J, Wang L, Wu Y, Xiang Q, Zhao Y, Zheng X, Jiang S, Sun Z, Fan D, Li W
Experimental & molecular medicine 2024 Mar;56(3):747-759
Experimental & molecular medicine 2024 Mar;56(3):747-759
RPL35 downregulated by mechanical overloading promotes chondrocyte senescence and osteoarthritis development via Hedgehog-Gli1 signaling.
Zhu J, Liu L, Lin R, Guo X, Yin J, Xie H, Lu Y, Zhang Z, Zhang H, Yao Z, Zhang H, Wang X, Zeng C, Cai D
Journal of orthopaedic translation 2024 Mar;45:226-235
Journal of orthopaedic translation 2024 Mar;45:226-235
Mitochondrial-targeting and NIR-responsive Mn(3)O(4)@PDA@Pd-SS31 nanozymes reduce oxidative stress and reverse mitochondrial dysfunction to alleviate osteoarthritis.
Li Y, Yang J, Chen X, Hu H, Lan N, Zhao J, Zheng L
Biomaterials 2024 Mar;305:122449
Biomaterials 2024 Mar;305:122449
Inhibition of SAT1 alleviates chondrocyte inflammation and ferroptosis by repressing ALOX15 expression and activating the Nrf2 pathway.
Xu J, Ruan Z, Guo Z, Hou L, Wang G, Zheng Z, Zhang X, Liu H, Sun K, Guo F
Bone & joint research 2024 Mar 7;13(3):110-123
Bone & joint research 2024 Mar 7;13(3):110-123
CircEYA3 aggravates intervertebral disc degeneration through the miR-196a-5p/EBF1 axis and NF-κB signaling.
Wang T, Yan X, Song D, Li Y, Li Z, Feng D
Communications biology 2024 Mar 30;7(1):390
Communications biology 2024 Mar 30;7(1):390
Gentiopicroside ameliorates the lipopolysaccharide-induced inflammatory response and hypertrophy in chondrocytes.
Li L, Fan Q, Zhao Y, Zhang Q, Qin G, Li C, Li W
Journal of orthopaedic surgery and research 2024 Mar 25;19(1):198
Journal of orthopaedic surgery and research 2024 Mar 25;19(1):198
Circular RNA CircFOXO3 Functions as a Competitive Endogenous RNA for Acid-Sensing Ion Channel Subunit 1 Mediating Oxeiptosis in Nucleus Pulposus.
Chen X, Song Y, Chen G, Zhang B, Bai Y, Sun C, Fan D, Chen Z
Biomedicines 2024 Mar 18;12(3)
Biomedicines 2024 Mar 18;12(3)
TfR1 mediated iron metabolism dysfunction as a potential therapeutic target for osteoarthritis.
Wang W, Ma Z, Feng X, Ren J, Sun S, Shao Y, Zhang W, Yang X, Zhang J, Jing X
Arthritis research & therapy 2024 Mar 16;26(1):71
Arthritis research & therapy 2024 Mar 16;26(1):71
Low-intensity pulsed ultrasound delays the progression of osteoarthritis by regulating the YAP-RIPK1-NF-κB axis and influencing autophagy.
Pan C, Lu F, Hao X, Deng X, Liu J, Sun K, Hou W, Shang X, Chi R, Guo F, Xu T
Journal of translational medicine 2024 Mar 16;22(1):286
Journal of translational medicine 2024 Mar 16;22(1):286
Oxymatrine protects articular chondrocytes from IL-1β-induced damage through autophagy activation via AKT/mTOR signaling pathway inhibition.
Lu J, Bian J, Wang Y, Zhao Y, Zhao X, Wang G, Yang J
Journal of orthopaedic surgery and research 2024 Mar 11;19(1):178
Journal of orthopaedic surgery and research 2024 Mar 11;19(1):178
Kongensin a attenuates intervertebral disc degeneration by inhibiting TAK1-mediated PANoptosis of nucleus pulposus cells.
Chen Y, Hu B, Ni F, Han Y, Shu S, Xiong L, Shao Z, Wei Y
International immunopharmacology 2024 Mar 10;129:111661
International immunopharmacology 2024 Mar 10;129:111661
Atractylenolide-III attenuates osteoarthritis by repolarizing macrophages through inactivating TLR4/NF-κB signaling.
Yi G, Zhang R, Li M, Song X, Li S
International immunopharmacology 2024 Mar 10;129:111629
International immunopharmacology 2024 Mar 10;129:111629
Moderate mechanical stress suppresses chondrocyte ferroptosis in osteoarthritis by regulating NF-κB p65/GPX4 signaling pathway.
Han J, Zhan LN, Huang Y, Guo S, Zhou X, Kapilevich L, Wang Z, Ning K, Sun M, Zhang XA
Scientific reports 2024 Mar 1;14(1):5078
Scientific reports 2024 Mar 1;14(1):5078
Apigetrin alleviates intervertebral disk degeneration by regulating nucleus pulposus cell autophagy.
Xu T, Zhao H, Li J, Fang X, Wu H, Hu W
JOR spine 2024 Jun;7(2):e1325
JOR spine 2024 Jun;7(2):e1325
A natural hydrogel complex improves intervertebral disc degeneration by correcting fatty acid metabolism and inhibiting nucleus pulposus cell pyroptosis.
Wang D, Zhang L, He D, Zhang Y, Zhao L, Miao Z, Cheng W, Zhu C, Shao Y, Ge G, Zhu H, Jin H, Zhang W, Pan H
Materials today. Bio 2024 Jun;26:101081
Materials today. Bio 2024 Jun;26:101081
A multifunctional nanogel encapsulating layered double hydroxide for enhanced osteoarthritis treatment via protection of chondrocytes and ECM.
Liu C, Sun Y, Li D, Wang F, Wang H, An S, Sun S
Materials today. Bio 2024 Jun;26:101034
Materials today. Bio 2024 Jun;26:101034
Platelet-rich plasma alleviates knee arthritis in rats by inhibiting p65.
Zhuo F, Jia X, Wang Z, Zhang Y, Yan X
Cell and tissue banking 2024 Jun;25(2):463-473
Cell and tissue banking 2024 Jun;25(2):463-473
Injectable Ozone-Rich Nanocomposite Hydrogel Loaded with D-Mannose for Anti-Inflammatory and Cartilage Protection in Osteoarthritis Treatment.
Wu H, Wang J, Lin Y, He W, Hou J, Deng M, Chen Y, Liu Q, Lu A, Cui Z, Guan D, Yu B
Small (Weinheim an der Bergstrasse, Germany) 2024 Jun;20(25):e2309597
Small (Weinheim an der Bergstrasse, Germany) 2024 Jun;20(25):e2309597
Botulinum toxin A attenuates osteoarthritis development via inhibiting chondrocyte ferroptosis through SLC7Al1/GPX4 axis.
Zeng L, Liu Y, Wang Q, Wan H, Meng X, Tu P, Chen H, Luo A, Hu P, Ding X
Biochimica et biophysica acta. Molecular basis of disease 2024 Jun;1870(5):167215
Biochimica et biophysica acta. Molecular basis of disease 2024 Jun;1870(5):167215
IL16 Regulates Osteoarthritis Progression as a Target Gene of Novel-miR-81.
Luo Z, Han Q, Lu J, Ouyang X, Fan Y, Liu Y, Zhou X, Kong J, Liu H, Liu A, Chen D
Cartilage 2024 Jun;15(2):175-183
Cartilage 2024 Jun;15(2):175-183
Development of primary osteoarthritis during aging in genetically diverse UM-HET3 mice.
Poudel SB, Ruff RR, Yildirim G, Miller RA, Harrison DE, Strong R, Kirsch T, Yakar S
Arthritis research & therapy 2024 Jun 8;26(1):118
Arthritis research & therapy 2024 Jun 8;26(1):118
A Novel Role for Protein Tyrosine Phosphatase 1B in Alleviating Chondrocyte Senescence.
Li HM, Che X, Tong Z, Wei W, Teng C
ACS omega 2024 Jun 25;9(25):27017-27029
ACS omega 2024 Jun 25;9(25):27017-27029
Identification of osteoblastic autophagy-related genes for predicting diagnostic markers in osteoarthritis.
Cai R, Jiang Q, Chen D, Feng Q, Liang X, Ouyang Z, Liao W, Zhang R, Fang H
iScience 2024 Jun 21;27(6):110130
iScience 2024 Jun 21;27(6):110130
S100A6 Regulates nucleus pulposus cell apoptosis via Wnt/β-catenin signaling pathway: an in vitro and in vivo study.
Yang F, Duan Y, Li Y, Zhu D, Wang Z, Luo Z, Zhang Y, Zhang G, He X, Kang X
Molecular medicine (Cambridge, Mass.) 2024 Jun 14;30(1):87
Molecular medicine (Cambridge, Mass.) 2024 Jun 14;30(1):87
Time-Dependent Effect of Eggshell Membrane on Monosodium-Iodoacetate-Induced Osteoarthritis: Early-Stage Inflammation Control and Late-Stage Cartilage Protection.
Yu M, Park C, Son YB, Jo SE, Jeon SH, Kim YJ, Han SB, Hong JT, Son DJ
Nutrients 2024 Jun 14;16(12)
Nutrients 2024 Jun 14;16(12)
Targeting the senescence-related genes MAPK12 and FOS to alleviate osteoarthritis.
Geng N, Xian M, Deng L, Kuang B, Pan Y, Liu K, Ye Y, Fan M, Bai Z, Guo F
Journal of orthopaedic translation 2024 Jul;47:50-62
Journal of orthopaedic translation 2024 Jul;47:50-62
TBK1 pharmacological inhibition mitigates osteoarthritis through attenuating inflammation and cellular senescence in chondrocytes.
Lu R, Qu Y, Wang Z, He Z, Xu S, Cheng P, Lv Z, You H, Guo F, Chen A, Zhang J, Liang S
Journal of orthopaedic translation 2024 Jul;47:207-222
Journal of orthopaedic translation 2024 Jul;47:207-222
Scutellarein alleviates osteoarthritis progression through the PI3K/Akt/NF-kappaB signaling pathway: In vitro and in vivo studies.
Ye Z, Ge Z, Yang S, Hu T, Ye Q, Chen H
Phytotherapy research : PTR 2024 Jul;38(7):3509-3524
Phytotherapy research : PTR 2024 Jul;38(7):3509-3524
Microenvironment-responsive metal-phenolic network release platform with ROS scavenging, anti-pyroptosis, and ECM regeneration for intervertebral disc degeneration.
Zhou H, He J, Liu R, Cheng J, Yuan Y, Mao W, Zhou J, He H, Liu Q, Tan W, Shuai C, Deng Y
Bioactive materials 2024 Jul;37:51-71
Bioactive materials 2024 Jul;37:51-71
MMP13-targeted siRNA-loaded micelles for diagnosis and treatment of posttraumatic osteoarthritis.
Zhou D, Wei Y, Sheng S, Wang M, Lv J, Zhao B, Chen X, Xu K, Bai L, Wu Y, Song P, Cao L, Zhou F, Zhang H, Shi Z, Su J
Bioactive materials 2024 Jul;37:378-392
Bioactive materials 2024 Jul;37:378-392
GPX7 reduces chondrocyte inflammation and extracellular matrix degradation triggered by IL‑1β, via a mechanism mediated by ferroptosis.
Chen B, Fu W, Jie C, Zhang G, Li Z, Liu Y, Zhou S
Molecular medicine reports 2024 Jul;30(1)
Molecular medicine reports 2024 Jul;30(1)
Acetyl-11-keto-β-boswellic acid restrains the progression of synovitis in osteoarthritis via the Nrf2/HO-1 pathway.
Zhou J, Li X, Han Z, Qian Y, Bai L, Han Q, Gao M, Xue Y, Geng D, Yang X, Hao Y
Acta biochimica et biophysica Sinica 2024 Jul 8;56(11):1644-1658
Acta biochimica et biophysica Sinica 2024 Jul 8;56(11):1644-1658
Quercetin Modulates Ferroptosis via the SIRT1/Nrf-2/HO-1 Pathway and Attenuates Cartilage Destruction in an Osteoarthritis Rat Model.
Ruan H, Zhu T, Wang T, Guo Y, Liu Y, Zheng J
International journal of molecular sciences 2024 Jul 7;25(13)
International journal of molecular sciences 2024 Jul 7;25(13)
Pain Relief, Functional Recovery, and Chondroprotective Effects of Angelica gigas Nakai in Osteoarthritis Due to Its Anti-Inflammatory Property: An In Vitro and In Vivo Study.
Jo HG, Baek CY, Hwang Y, Baek E, Song HS, Lee D
Nutrients 2024 Jul 26;16(15)
Nutrients 2024 Jul 26;16(15)
Fabrication of heterocellular spheroids with controllable core-shell structure using inertial focusing effect for scaffold-free 3D cell culture models.
Tang T, Zhang P, Zhang Q, Man X, Xu Y
Biofabrication 2024 Jul 25;16(4)
Biofabrication 2024 Jul 25;16(4)
IRF1 regulation of ZBP1 links mitochondrial DNA and chondrocyte damage in osteoarthritis.
Sun K, Lu F, Hou L, Zhang X, Pan C, Liu H, Zheng Z, Guo Z, Ruan Z, Hou Y, Zhang J, Guo F, Zhu W
Cell communication and signaling : CCS 2024 Jul 18;22(1):366
Cell communication and signaling : CCS 2024 Jul 18;22(1):366
Circadian rhythm disruption upregulating Per1 in mandibular condylar chondrocytes mediating temporomandibular joint osteoarthritis via GSK3β/β-CATENIN pathway.
Wei J, Wang Y, Tu S, Zhang S, Feng Y, Hou Y, Ai H, Chen Z
Journal of translational medicine 2024 Jul 15;22(1):662
Journal of translational medicine 2024 Jul 15;22(1):662
Rescue of nucleus pulposus cells from an oxidative stress microenvironment via glutathione-derived carbon dots to alleviate intervertebral disc degeneration.
Bu W, Shi Y, Huang X, Wu S, Jiang L, Pan C, Li D, Xu Z, Wang H, Chen H, Du J
Journal of nanobiotechnology 2024 Jul 12;22(1):412
Journal of nanobiotechnology 2024 Jul 12;22(1):412
The Combined Intraosseous Administration of Orthobiologics Outperformed Isolated Intra-articular Injections in Alleviating Pain and Cartilage Degeneration in a Rat Model of MIA-Induced Knee Osteoarthritis.
Zhang K, Yu J, Li J, Fu W
The American journal of sports medicine 2024 Jan;52(1):140-154
The American journal of sports medicine 2024 Jan;52(1):140-154
TCF12 regulates the TGF-β/Smad2/3 signaling pathway to accelerate the progression of osteoarthritis by targeting CXCR4.
Zheng H, Fang J, Lu W, Liu Y, Chen S, Huang G, Zou Y, Hu S, Zheng Y, Fang H, Zhang R
Journal of orthopaedic translation 2024 Jan;44:35-46
Journal of orthopaedic translation 2024 Jan;44:35-46
microRNA-365 attenuated intervertebral disc degeneration through modulating nucleus pulposus cell apoptosis and extracellular matrix degradation by targeting EFNA3.
Jiang C, Liu Y, Zhao W, Yang Y, Ren Z, Wang X, Hao D, Du H, Yin S
Journal of cellular and molecular medicine 2024 Jan;28(2):e18054
Journal of cellular and molecular medicine 2024 Jan;28(2):e18054
CircIRAK3 exerts negative feedback regulation on inflammation by binding to HNRNP U and destabilizing proinflammatory cytokine mRNA in osteoarthritis and chondrogenesis.
Wen X, Fang G, Li H, Jiang Z, Du X, Liao Z, Liu R, Huang G, Meng F, Liao W, Zhang Z
International journal of biological macromolecules 2024 Jan;256(Pt 2):128453
International journal of biological macromolecules 2024 Jan;256(Pt 2):128453
Moxibustion ameliorates osteoarthritis by regulating gut microbiota via impacting cAMP-related signaling pathway.
Fu L, Duan H, Cai Y, Chen X, Zou B, Yuan L, Liu G
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jan;170:116031
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jan;170:116031
Gut-joint axis: Oral Probiotic ameliorates Osteoarthritis.
Amin U, Jiang R, Raza SM, Fan M, Liang L, Feng N, Li X, Yang Y, Guo F
Journal of traditional and complementary medicine 2024 Jan;14(1):26-39
Journal of traditional and complementary medicine 2024 Jan;14(1):26-39
Ganoderic acid A slows osteoarthritis progression by attenuating endoplasmic reticulum stress and blocking NF-Κb pathway.
Liu Y, Zhou C, Tan J, Wu T, Pan C, Liu J, Cheng X
Chemical biology & drug design 2024 Jan;103(1):e14382
Chemical biology & drug design 2024 Jan;103(1):e14382
Exercise-induced modulation of myokine irisin on muscle-bone unit in the rat model of post-traumatic osteoarthritis.
Shang X, Hao X, Hou W, Liu J, Chi R, Deng X, Pan C, Xu T
Journal of orthopaedic surgery and research 2024 Jan 9;19(1):49
Journal of orthopaedic surgery and research 2024 Jan 9;19(1):49
Danggui-Shaoyao-San (DSS) ameliorates the progression of osteoarthritis via suppressing the NF-κB signaling pathway: an in vitro and in vivo study combined with bioinformatics analysis.
Chen S, Kang P, Zhao Z, Zhang H, Li J, Xu K, Gong D, Jiao F, Wang H, Zhang M
Aging 2024 Jan 8;16(1):648-664
Aging 2024 Jan 8;16(1):648-664
Carveol alleviates osteoarthritis progression by acting on synovial macrophage polarization transformation: An in vitro and in vivo study.
Chen S, Xu H, He Y, Meng C, Fan Y, Qu Y, Wang Y, Zhou W, Huang X, You H
Chemico-biological interactions 2024 Jan 5;387:110781
Chemico-biological interactions 2024 Jan 5;387:110781
Sesamin-mediated high expression of BECN2 ameliorates cartilage endplate degeneration by reducing autophagy and inflammation.
Zhang B, He Z, Guo J, Li F, Huang Z, Zheng W, Xing W, Li M, Zhu Y, Yang X
Aging 2024 Jan 26;16(2):1145-1160
Aging 2024 Jan 26;16(2):1145-1160
The protective effect of Ergolide in osteoarthritis: In vitro and in vivo studies.
Meng X, Sun L, Meng X, Bi Q
International immunopharmacology 2024 Jan 25;127:111355
International immunopharmacology 2024 Jan 25;127:111355
Single-cell atlas of human infrapatellar fat pad and synovium implicates APOE signaling in osteoarthritis pathology.
Tang S, Yao L, Ruan J, Kang J, Cao Y, Nie X, Lan W, Zhu Z, Han W, Liu Y, Tian J, Seale P, Qin L, Ding C
Science translational medicine 2024 Jan 24;16(731):eadf4590
Science translational medicine 2024 Jan 24;16(731):eadf4590
Selenium-SelK-GPX4 axis protects nucleus pulposus cells against mechanical overloading-induced ferroptosis and attenuates senescence of intervertebral disc.
Jia C, Xiang Z, Zhang P, Liu L, Zhu X, Yu R, Liu Z, Wang S, Liu K, Wang Z, Vasilev K, Zhou S, Geng Z, Liu X, Zhao Y, Gao Y, Cheng L, Li Y
Cellular and molecular life sciences : CMLS 2024 Jan 22;81(1):49
Cellular and molecular life sciences : CMLS 2024 Jan 22;81(1):49
Development of primary osteoarthritis during aging in genetically diverse UM-HET3 mice.
Poudel SB, Ruff RR, Yildirim G, Miller RA, Harrison DE, Strong R, Kirsch T, Yakar S
Research square 2024 Jan 22;
Research square 2024 Jan 22;
The CREB1 inhibitor 666-15 maintains cartilage homeostasis and mitigates osteoarthritis progression.
Wang Y, Wu Z, Yan G, Li S, Zhang Y, Li G, Wu C
Bone & joint research 2024 Jan 2;13(1):4-18
Bone & joint research 2024 Jan 2;13(1):4-18
Development of primary osteoarthritis during aging in genetically diverse UM-HET3 mice.
Poudel SB, Ruff RR, Yildirim G, Miller RA, Harrison DE, Strong R, Kirsch T, Yakar S
bioRxiv : the preprint server for biology 2024 Jan 14;
bioRxiv : the preprint server for biology 2024 Jan 14;
General Control Non-derepressible 2 Alleviates Cartilage Degeneration and Inhibits NLRP3 Inflammasome Activation in Osteoarthritis.
Fang L, Wang Z, Liu J, Lin Y, Hao W
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2024 Feb;72(2):95-108
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2024 Feb;72(2):95-108
Nrf2 protects against cartilage endplate degeneration through inhibiting NCOA4‑mediated ferritinophagy.
Ma Z, Lu H, Feng X, Du T, Li J, Zhang Q, Gu X, Shao Y, Jing X, Su C
International journal of molecular medicine 2024 Feb;53(2)
International journal of molecular medicine 2024 Feb;53(2)
The sonic hedgehog pathway suppresses oxidative stress and senescence in nucleus pulposus cells to alleviate intervertebral disc degeneration via GPX4.
Zhuang Y, Liu L, Liu M, Fu J, Ai X, Long D, Leng X, Zhang Y, Gong X, Shang X, Li C, Huang B, Zhou Y, Ning X, Dong S, Feng C
Biochimica et biophysica acta. Molecular basis of disease 2024 Feb;1870(2):166961
Biochimica et biophysica acta. Molecular basis of disease 2024 Feb;1870(2):166961
Network Pharmacology and Experimental Verifications to Discover Scutellaria baicalensis Georgi's Effects on Joint Inflammation, Destruction, and Pain in Osteoarthritis.
Jo HG, Baek CY, Song HS, Lee D
International journal of molecular sciences 2024 Feb 9;25(4)
International journal of molecular sciences 2024 Feb 9;25(4)
Loss of Slc39a12 in hippocampal neurons is responsible for anxiety-like behavior caused by temporomandibular joint osteoarthritis.
Shen Z, Fan C, Ding C, Xu M, Wu X, Wang Y, Xing T
Heliyon 2024 Feb 29;10(4):e26271
Heliyon 2024 Feb 29;10(4):e26271
Fisetin suppresses chondrocyte senescence and attenuates osteoarthritis progression by targeting sirtuin 6.
Wang X, Li X, Zhou J, Lei Z, Yang X
Chemico-biological interactions 2024 Feb 25;390:110890
Chemico-biological interactions 2024 Feb 25;390:110890
P21 resists ferroptosis in osteoarthritic chondrocytes by regulating GPX4 protein stability.
Zheng Z, Shang X, Sun K, Hou Y, Zhang X, Xu J, Liu H, Ruan Z, Hou L, Guo Z, Wang G, Xu F, Guo F
Free radical biology & medicine 2024 Feb 20;212:336-348
Free radical biology & medicine 2024 Feb 20;212:336-348
Inhibition of HOXD11 promotes cartilage degradation and induces osteoarthritis development.
Hong Q, Liu ZX, Liang HF, Wu DG, Chen Y, Yu B
Journal of orthopaedic surgery and research 2024 Feb 2;19(1):111
Journal of orthopaedic surgery and research 2024 Feb 2;19(1):111
Analysis and identification of ferroptosis-related diagnostic markers in rheumatoid arthritis.
Cai Y, Deng L, Yao J
Annals of medicine 2024 Dec;56(1):2397572
Annals of medicine 2024 Dec;56(1):2397572
Novel injectable adhesive hydrogel loaded with exosomes for holistic repair of hemophilic articular cartilage defect.
Yang Q, Liu G, Chen G, Chen G, Chen K, Fan L, Tu Y, Chen J, Shi Z, Chen C, Liu S, Deng G, Deng X, Sun C, Li X, Yang S, Zheng S, Chen B
Bioactive materials 2024 Dec;42:85-111
Bioactive materials 2024 Dec;42:85-111
Esculin Alleviates Osteoarthritis Progression Through the Sirt1/NF-κB Pathway.
Sun T, Bai B, Wu H, Xing H, Li J
Phytotherapy research : PTR 2024 Dec;38(12):5793-5805
Phytotherapy research : PTR 2024 Dec;38(12):5793-5805
An injectable self-lubricating supramolecular polymer hydrogel loaded with platelet lysate to boost osteoarthritis treatment.
Zhang P, Yang J, Wang Z, Wang H, An M, Yakufu M, Wang W, Liu Y, Liu W, Li C
Journal of controlled release : official journal of the Controlled Release Society 2024 Dec;376:20-36
Journal of controlled release : official journal of the Controlled Release Society 2024 Dec;376:20-36
Enhanced therapeutic potential of a self-healing hyaluronic acid hydrogel for early intervention in osteoarthritis.
Wu D, Yang S, Gong Z, Zhu X, Hong J, Wang H, Xu W, Lai J, Wang X, Lu J, Fang X, Jiang G, Zhu J
Materials today. Bio 2024 Dec;29:101353
Materials today. Bio 2024 Dec;29:101353
MSCs-derived ECM functionalized hydrogel regulates macrophage reprogramming for osteoarthritis treatment by improving mitochondrial function and energy metabolism.
Chen Z, Pang Q, Zhan J, Liu J, Zhao W, Dong L, Huang W
Materials today. Bio 2024 Dec;29:101340
Materials today. Bio 2024 Dec;29:101340
The active ingredient of Evodia rutaecarpa reduces inflammation in knee osteoarthritis rats through blocking calcium influx and NF-κB pathway.
Gao Y, Wang S, Gao Y, Yang L
Basic & clinical pharmacology & toxicology 2024 Dec;135(6):705-719
Basic & clinical pharmacology & toxicology 2024 Dec;135(6):705-719
Lycopodium japonicum Thunb. inhibits chondrocyte apoptosis, senescence and inflammation in osteoarthritis through STING/NF-κB signaling pathway.
Ma J, Zhang H, Wang Z, Xu C, Tan H, Sun Y, Zheng R, Jin Z, Li Y, Ge X, Wu Y, Zhou Y
Journal of ethnopharmacology 2024 Dec 5;335:118660
Journal of ethnopharmacology 2024 Dec 5;335:118660
A human organoid drug screen identifies α2-adrenergic receptor signaling as a therapeutic target for cartilage regeneration.
Wei X, Qiu J, Lai R, Wei T, Lin Z, Huang S, Jiang Y, Kuang Z, Zeng H, Gong Y, Xie X, Yang J, Zhang Y, Zhang S, Zou Z, Gao X, Bai X
Cell stem cell 2024 Dec 5;31(12):1813-1830.e8
Cell stem cell 2024 Dec 5;31(12):1813-1830.e8
Ginkgolide A enhances FoxO1 expression and reduces endoplasmic reticulum stress to mitigate osteoarthritis in mice.
Yu H, Liang J, Bao Y, Chen K, Jin Y, Li X, Chen H, Gou Y, Lu K, Lin Z
International immunopharmacology 2024 Dec 5;142(Pt B):113116
International immunopharmacology 2024 Dec 5;142(Pt B):113116
Kongensin A targeting PI3K attenuates inflammation-induced osteoarthritis by modulating macrophage polarization and alleviating inflammatory signaling.
Guo Y, Wang P, Hu B, Wang L, Zhang Y, Wang J
International immunopharmacology 2024 Dec 5;142(Pt A):112948
International immunopharmacology 2024 Dec 5;142(Pt A):112948
High-Intensity Interval Training Increases Osteoarthritis-Associated Pain-Sensitive Threshold Through Reduction of Perineuronal Nets of the Medial Prefrontal Cortex in Rats.
Zhang X, Kong FE, Lin CS, Ye ZQ, Chen AL, Cheng K, Li XP
Physiological research 2024 Dec 31;73(6):1085-1097
Physiological research 2024 Dec 31;73(6):1085-1097
Guilu Erxian glue reduces endoplasmic reticulum stress-mediated apoptosis and restores the balance of extracellular matrix synthesis and degradation in chondrocytes by inhibiting the ATF6/GRP78/CHOP signaling pathway.
Geng Q, Wu W, Yang M, Gu F, Cai W, Qin Y, Wei L, Wang H, Li N
Heliyon 2024 Dec 30;10(24):e39987
Heliyon 2024 Dec 30;10(24):e39987
Identification and validation of up-regulated TNFAIP6 in osteoarthritis with type 2 diabetes mellitus.
Liu S, Chen H, Yang X, Wen Y, Chen L
Scientific reports 2024 Dec 28;14(1):31450
Scientific reports 2024 Dec 28;14(1):31450
T-2 toxin induces chondrocyte extracellular matrix degradation by regulating the METTL3-mediated Ctsk m6A modification.
Zhang B, Li H, Qi F, Yu Q, Jiang H, Lin B, Dong H, Li H, Yu J
International immunopharmacology 2024 Dec 25;143(Pt 2):113390
International immunopharmacology 2024 Dec 25;143(Pt 2):113390
Wedelolactone alleviates inflammation and cartilage degeneration by suppressing the NF-κB signaling pathway in osteoarthritis.
Sun W, Yue J, Cui Y, Feng J, He Q, Liang J, You W, Shi H, Sun W, Yi Q
International immunopharmacology 2024 Dec 25;143(Pt 1):113359
International immunopharmacology 2024 Dec 25;143(Pt 1):113359
Targeted lipid nanoparticles distributed in hydrogel treat osteoarthritis by modulating cholesterol metabolism and promoting endogenous cartilage regeneration.
Zhao Z, Wang P, Li Z, Wei X, Li S, Lu X, Dai S, Huang B, Man Z, Li W
Journal of nanobiotechnology 2024 Dec 20;22(1):786
Journal of nanobiotechnology 2024 Dec 20;22(1):786
Celecoxib Combined with Tocilizumab Has Anti-Inflammatory Effects and Promotes the Recovery of Damaged Cartilage via the Nrf2/HO-1 Pathway In Vitro.
Shimasaki M, Ueda S, Sakurai M, Kawahara N, Ueda Y, Ichiseki T
Biomolecules 2024 Dec 20;14(12)
Biomolecules 2024 Dec 20;14(12)
Potential Effects of Indomethacin on Alleviating Osteoarthritis Progression in Vitro.
Zhao X, Wang T, Li N, Meng Z, Wang W, Wang B, Song D
Journal of musculoskeletal & neuronal interactions 2024 Dec 1;24(4):409-419
Journal of musculoskeletal & neuronal interactions 2024 Dec 1;24(4):409-419
Nrf2 activation by pyrroloquinoline quinone inhibits natural aging-related intervertebral disk degeneration in mice.
Xue Q, Li J, Qin R, Li M, Li Y, Zhang J, Wang R, Goltzman D, Miao D, Yang R
Aging cell 2024 Aug;23(8):e14202
Aging cell 2024 Aug;23(8):e14202
Excessive mechanical loading promotes osteoarthritis development by upregulating Rcn2.
Liu Y, Chen P, Hu B, Xiao Y, Su T, Luo X, Tu M, Cai G
Biochimica et biophysica acta. Molecular basis of disease 2024 Aug;1870(6):167251
Biochimica et biophysica acta. Molecular basis of disease 2024 Aug;1870(6):167251
Zwitterion-Lubricated Hydrogel Microspheres Encapsulated with Metformin Ameliorate Age-Associated Osteoarthritis.
Hou J, Lin Y, Zhu C, Chen Y, Lin R, Lin H, Liu D, Guan D, Yu B, Wang J, Wu H, Cui Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(30):e2402477
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(30):e2402477
Mulberroside A mitigates intervertebral disc degeneration by inhibiting MAPK and modulating Ppar-γ/NF-κB pathways.
Xu T, Zhao H, Fang X, Wang S, Li J, Wu H, Hu W, Lu R
Journal of inflammation (London, England) 2024 Aug 28;21(1):32
Journal of inflammation (London, England) 2024 Aug 28;21(1):32
4-Octyl itaconate protects chondrocytes against IL-1β-induced oxidative stress and ferroptosis by inhibiting GPX4 methylation in osteoarthritis.
Pan X, Kong X, Feng Z, Jin Z, Wang M, Lu H, Chen G
International immunopharmacology 2024 Aug 20;137:112531
International immunopharmacology 2024 Aug 20;137:112531
Oxygen vacancy-engineered cerium oxide mediated by copper-platinum exhibit enhanced SOD/CAT-mimicking activities to regulate the microenvironment for osteoarthritis therapy.
Yang J, Xiao S, Deng J, Li Y, Hu H, Wang J, Lu C, Li G, Zheng L, Wei Q, Zhong J
Journal of nanobiotechnology 2024 Aug 18;22(1):491
Journal of nanobiotechnology 2024 Aug 18;22(1):491
Matrix stiffness aggravates osteoarthritis progression through H3K27me3 demethylation induced by mitochondrial damage.
Kan T, Li H, Hou L, Cui J, Wang Y, Sun L, Wang L, Yan M, Yu Z
iScience 2024 Aug 16;27(8):110507
iScience 2024 Aug 16;27(8):110507
METTL3 Promotes Nucleus Pulposus Cell Senescence in Intervertebral Disc Degeneration by Regulating TLR2 m6A Methylation and Gut Microbiota.
Ni S, Huang X, Li X, Shi C, Fan M, Zhao L, Rong Z, Zhang H
The journals of gerontology. Series A, Biological sciences and medical sciences 2024 Aug 1;79(8)
The journals of gerontology. Series A, Biological sciences and medical sciences 2024 Aug 1;79(8)
Inhibiting DNA methyltransferase DNMT3B confers protection against ferroptosis in nucleus pulposus and ameliorates intervertebral disc degeneration via upregulating SLC40A1.
Chen J, Yang X, Li Q, Ma J, Li H, Wang L, Chen Z, Quan Z
Free radical biology & medicine 2024 Aug 1;220:139-153
Free radical biology & medicine 2024 Aug 1;220:139-153
Scutellarein Ameliorated Chondrocyte Inflammation and Osteoarthritis in Rats.
Jing SZ, Yang SH, Qu YK, Hao HH, Wu H
Current medical science 2024 Apr;44(2):355-368
Current medical science 2024 Apr;44(2):355-368
Baicalin Maintains Articular Cartilage Homeostasis and Alleviates Osteoarthritis by Activating FOXO1.
Wei Q, Yu Z, Yang P, Chen X
Journal of medicinal food 2024 Apr;27(4):301-311
Journal of medicinal food 2024 Apr;27(4):301-311
Spermidine ameliorates osteoarthritis via altering macrophage polarization.
Ou Q, Tang S, Zhu J, Xue S, Huang H, Zhao Y, Cai Y, Wu C, Chen J, Ruan G, Ding C
Biochimica et biophysica acta. Molecular basis of disease 2024 Apr;1870(4):167083
Biochimica et biophysica acta. Molecular basis of disease 2024 Apr;1870(4):167083
Inflammatory Fibroblast-Like Synoviocyte-Derived Exosomes Aggravate Osteoarthritis via Enhancing Macrophage Glycolysis.
Liu B, Xian Y, Chen X, Shi Y, Dong J, Yang L, An X, Shen T, Wu W, Ma Y, He Y, Gong W, Peng R, Lin J, Liu N, Guo B, Jiang Q
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Apr;11(14):e2307338
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Apr;11(14):e2307338
Gold nanoparticles exhibit anti-osteoarthritic effects via modulating interaction of the "microbiota-gut-joint" axis.
Deng Z, Yang C, Xiang T, Dou C, Sun D, Dai Q, Ling Z, Xu J, Luo F, Chen Y
Journal of nanobiotechnology 2024 Apr 8;22(1):157
Journal of nanobiotechnology 2024 Apr 8;22(1):157
Confirmation of pain-related neuromodulation mechanism of Bushen Zhuangjin Decoction on knee osteoarthritis.
Tan X, Zheng D, Lin Q, Wang L, Zhu Z, Huang Y, Lin J, Zeng Y, Mao M, Yi Z, Liu L, Ma D, Wang J, Li X
Journal of ethnopharmacology 2024 Apr 24;324:117772
Journal of ethnopharmacology 2024 Apr 24;324:117772
AP39 through AMPK-ULK1-FUNDC1 pathway regulates mitophagy, inhibits pyroptosis, and improves doxorubicin-induced myocardial fibrosis.
Zhao J, Yang T, Yi J, Hu H, Lai Q, Nie L, Liu M, Chu C, Yang J
iScience 2024 Apr 19;27(4):109321
iScience 2024 Apr 19;27(4):109321
Verapamil Attenuates the Severity of Tendinopathy by Mitigating Mitochondrial Dysfunction through the Activation of the Nrf2/HO-1 Pathway.
Wang Z, Dong Z, Li Y, Jiao X, Liu Y, Chang H, Gan Y
Biomedicines 2024 Apr 18;12(4)
Biomedicines 2024 Apr 18;12(4)
Biomimetic zwitterionic copolymerized chitosan as an articular lubricant.
Deng J, Wei R, Qiu H, Wu X, Yang Y, Huang Z, Miao J, Liu A, Chai H, Cen X, Wang R
Carbohydrate polymers 2024 Apr 15;330:121821
Carbohydrate polymers 2024 Apr 15;330:121821
pH-Responsive Delivery of H2 through Ammonia Borane-Loaded Hollow Polydopamine for Intervertebral Disc Degeneration Therapy.
Wang W, Xiao B, Qiu Y, Liu Y, Tang G, Deng G, Xi Y, Xu G, Wang Y
Oxidative medicine and cellular longevity 2023;2023:7773609
Oxidative medicine and cellular longevity 2023;2023:7773609
The Role of the miR-548au-3p/CA12 Axis in Tracheal Chondrogenesis in Congenital Pulmonary Airway Malformations.
Zeng J, Zhang X, Yang Q, Peng J, Wang F, Tang J, Xu Y, Huang D, Liang J, Li L
Oxidative medicine and cellular longevity 2023;2023:6428579
Oxidative medicine and cellular longevity 2023;2023:6428579
Betulinic Acid Attenuates Osteoarthritis via Limiting NLRP3 Inflammasome Activation to Decrease Interleukin-1β Maturation and Secretion.
Liu B, Wu Y, Liang T, Zhou Y, Chen G, He J, Ji C, Liu P, Zhang C, Lin J, Shi K, Luo Z, Liu N, Su X
Mediators of inflammation 2023;2023:3706421
Mediators of inflammation 2023;2023:3706421
1,25-Dihydroxyvitamin D Deficiency Accelerates Aging-related Osteoarthritis via Downregulation of Sirt1 in Mice.
Chen J, Zhang J, Li J, Qin R, Lu N, Goltzman D, Miao D, Yang R
International journal of biological sciences 2023;19(2):610-624
International journal of biological sciences 2023;19(2):610-624
Pioglitazone-Loaded Cartilage-Targeted Nanomicelles (Pio@C-HA-DOs) for Osteoarthritis Treatment.
Chen J, Xu W, Dai T, Jiao S, Xue X, Jiang J, Li S, Meng Q
International journal of nanomedicine 2023;18:5871-5890
International journal of nanomedicine 2023;18:5871-5890
The Protective Effect of Selenium Nanoparticles in Osteoarthritis: In vitro and in vivo Studies.
Li Y, Zhu S, Luo J, Tong Y, Zheng Y, Ji L, He Z, Jing Q, Huang J, Zhang Y, Bi Q
Drug design, development and therapy 2023;17:1515-1529
Drug design, development and therapy 2023;17:1515-1529
Therapeutic Effect of Acupotomy at Sanheyang for Cartilage Collagen Damage in Moderate Knee Osteoarthritis: A Rabbit Model.
Li Y, Hou Y, Sun J, Wei J, Chai Y, Guo M, Wang R
Journal of inflammation research 2023;16:2241-2254
Journal of inflammation research 2023;16:2241-2254
Digoxin protects against intervertebral disc degeneration via TNF/NF-κB and LRP4 signaling.
Meng Q, Liu K, Liu Z, Liu J, Tian Z, Qin S, Wei J, Cheng L
Frontiers in immunology 2023;14:1251517
Frontiers in immunology 2023;14:1251517
Identification of EGFR as an essential regulator in chondrocytes ferroptosis of osteoarthritis using bioinformatics, in vivo, and in vitro study.
Sun H, Peng G, Chen K, Xiong Z, Zhuang Y, Liu M, Ning X, Yang H, Deng J
Heliyon 2023 Sep;9(9):e19975
Heliyon 2023 Sep;9(9):e19975
Donor-Matched Peripheral Blood-Derived Mesenchymal Stem Cells Combined With Platelet-Rich Plasma Synergistically Ameliorate Surgery-Induced Osteoarthritis in Rabbits: An In Vitro and In Vivo Study.
Zhang K, Xu T, Xie H, Li J, Fu W
The American journal of sports medicine 2023 Sep;51(11):3008-3024
The American journal of sports medicine 2023 Sep;51(11):3008-3024
Notopterol alleviates the progression of osteoarthritis: An in vitro and in vivo study.
Qu Y, Qiu L, Qiu H, Shen Y, Tang M, Huang Y, Peng Y, Wang J, Fu Q
Cytokine 2023 Sep;169:156309
Cytokine 2023 Sep;169:156309
Cynarin alleviates intervertebral disc degeneration via protecting nucleus pulposus cells from ferroptosis.
Zhang P, Rong K, Guo J, Cui L, Kong K, Zhao C, Yang H, Xu H, Qin A, Ma P, Yang X, Zhao J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Sep;165:115252
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Sep;165:115252
Engineering exosomes derived from subcutaneous fat MSCs specially promote cartilage repair as miR-199a-3p delivery vehicles in Osteoarthritis.
Zhao S, Xiu G, Wang J, Wen Y, Lu J, Wu B, Wang G, Yang D, Ling B, Du D, Xu J
Journal of nanobiotechnology 2023 Sep 22;21(1):341
Journal of nanobiotechnology 2023 Sep 22;21(1):341
Genistein Suppresses IL-6 and MMP-13 to Attenuate Osteoarthritis in Obese Diabetic Mice.
Lopez J, Al-Nakkash L, Broderick TL, Castro M, Tobin B, Plochocki JH
Metabolites 2023 Sep 14;13(9)
Metabolites 2023 Sep 14;13(9)
Rutaecarpine ameliorates osteoarthritis by inhibiting PI3K/AKT/NF‑κB and MAPK signalling transduction through integrin αVβ3.
Wan J, Li M, Yuan X, Yu X, Chen A, Shao M, Kang H, Cheng P
International journal of molecular medicine 2023 Oct;52(4)
International journal of molecular medicine 2023 Oct;52(4)
An in vitro and in vivo study: Valencene protects cartilage and alleviates the progression of osteoarthritis by anti-oxidative stress and anti-inflammatory effects.
Chen S, Meng C, He Y, Xu H, Qu Y, Wang Y, Fan Y, Huang X, You H
International immunopharmacology 2023 Oct;123:110726
International immunopharmacology 2023 Oct;123:110726
Ganoderma lucidum polysaccharide peptide (GLPP) attenuates rheumatic arthritis in rats through inactivating NF-κB and MAPK signaling pathways.
Meng M, Wang L, Yao Y, Lin D, Wang C, Yao J, Sun H, Liu M
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Oct;119:155010
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Oct;119:155010
Systemic pharmacology reveal the mechanism by which the Qiangjin Zhuanggu Qufeng mixture inhibits LPS-induced pyroptosis of rat nucleus pulposus cells.
Wang D, Zhang L, He D, Zhang Y, Bao J, Gao W, Cheng W, Zhu C, Jin H, Zhang W, Zhu H, Pan H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Oct;119:154998
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Oct;119:154998
Clock gene Per1 regulates rat temporomandibular osteoarthritis through NF-κB pathway: an in vitro and in vivo study.
Wei JM, Tu SQ, Wang YX, Zhang S, Feng Y, Ai H, Chen Z
Journal of orthopaedic surgery and research 2023 Oct 31;18(1):817
Journal of orthopaedic surgery and research 2023 Oct 31;18(1):817
Low-intensity pulsed ultrasound irradiation attenuates collagen degradation of articular cartilage in early osteoarthritis-like model mice.
Kojima Y, Watanabe T
Journal of experimental orthopaedics 2023 Oct 23;10(1):106
Journal of experimental orthopaedics 2023 Oct 23;10(1):106
ALKBH5-mediated m(6)A demethylation of HS3ST3B1-IT1 prevents osteoarthritis progression.
Tang Y, Liu Y, Zhu X, Chen Y, Jiang X, Ding S, Zheng Q, Zhang M, Yang J, Ma Y, Xing M, Zhang Z, Ding H, Jin Y, Ma C
iScience 2023 Oct 20;26(10):107838
iScience 2023 Oct 20;26(10):107838
Focused low-intensity pulsed ultrasound alleviates osteoarthritis via restoring impaired FUNDC1-mediated mitophagy.
Ye H, Li D, Wei X, Yu L, Jia L
iScience 2023 Oct 20;26(10):107772
iScience 2023 Oct 20;26(10):107772
Repair of osteochondral defects: efficacy of a tissue-engineered hybrid implant containing both human MSC and human iPSC-cartilaginous particles.
Nakagawa S, Ando W, Shimomura K, Hart DA, Hanai H, Jacob G, Chijimatsu R, Yarimitu S, Fujie H, Okada S, Tsumaki N, Nakamura N
NPJ Regenerative medicine 2023 Oct 19;8(1):59
NPJ Regenerative medicine 2023 Oct 19;8(1):59
Pentraxin 3 deficiency ameliorates the severity of osteoarthritis and alleviates inflammation.
Qiu C, Liu J, Li J, Di D, Li M, Liu T, Wang X, Zhao Y, Wang L, Liu X
Biochemical and biophysical research communications 2023 Oct 15;677:20-25
Biochemical and biophysical research communications 2023 Oct 15;677:20-25
Dapagliflozin suppress endoplasmic reticulum stress mediated apoptosis of chondrocytes by activating Sirt1.
Liu Z, Huang J, Wang X, Deng S, Zhou J, Gong Z, Li X, Wang Y, Yang J, Hu Y
Chemico-biological interactions 2023 Oct 1;384:110724
Chemico-biological interactions 2023 Oct 1;384:110724
α-Ketoglutaric acid ameliorates intervertebral disk degeneration by blocking the IL-6/JAK2/STAT3 pathway.
Xu HW, Fang XY, Liu XW, Zhang SB, Yi YY, Chang SJ, Chen H, Wang SJ
American journal of physiology. Cell physiology 2023 Oct 1;325(4):C1119-C1130
American journal of physiology. Cell physiology 2023 Oct 1;325(4):C1119-C1130
Xanthohumol alleviates palmitate-induced inflammation and prevents osteoarthritis progression by attenuating mitochondria dysfunction/NLRP3 inflammasome axis.
Sun W, Yue J, Xu T, Cui Y, Huang D, Shi H, Xiong J, Sun W, Yi Q
Heliyon 2023 Nov;9(11):e21282
Heliyon 2023 Nov;9(11):e21282
Orientin inhibits inflammation in chondrocytes and attenuates osteoarthritis through Nrf2/NF-κB and SIRT6/NF-κB pathway.
Xia W, Xiao J, Tong C, Lu J, Tu Y, Li S, Ni L, Shi Y, Luo P, Zhang X, Wang X
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2023 Nov;41(11):2405-2417
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2023 Nov;41(11):2405-2417
Pacenta polypeptide injection alleviates the fibrosis and inflammation in cigarette smoke extracts-induced BEAS-2B cells by modulating MMP-9/TIMP-1 signaling.
Xu W, Li F, Zhu L, Cheng M, Cheng Y
Journal of biochemical and molecular toxicology 2023 Nov;37(11):e23453
Journal of biochemical and molecular toxicology 2023 Nov;37(11):e23453
Acetyl zingerone ameliorates osteoarthritis by inhibiting chondrocyte programmed cell death.
Chen X, Chen J, Miao C, Yin G, Zhang Z, Sun R, Ni S
Molecular medicine reports 2023 Nov;28(5)
Molecular medicine reports 2023 Nov;28(5)
Epigenetic PPARγ preservation attenuates temporomandibular joint osteoarthritis.
Hua B, Qiu J, Ye X, Kuang Y, Liu X
International immunopharmacology 2023 Nov;124(Pt B):111014
International immunopharmacology 2023 Nov;124(Pt B):111014
Pyroptosis of chondrocytes activated by synovial inflammation accelerates TMJ osteoarthritis cartilage degeneration via ROS/NLRP3 signaling.
Liu X, Li Y, Zhao J, Hu Z, Fang W, Ke J, Li W, Long X
International immunopharmacology 2023 Nov;124(Pt A):110781
International immunopharmacology 2023 Nov;124(Pt A):110781
Rspo2 exacerbates rheumatoid arthritis by targeting aggressive phenotype of fibroblast-like synoviocytes and disrupting chondrocyte homeostasis via Wnt/β-catenin pathway.
Guo D, Pan H, Lu X, Chen Z, Zhou L, Chen S, Huang J, Liang X, Xiao Z, Zeng H, Shao Y, Qi W, Xie D, Lin C
Arthritis research & therapy 2023 Nov 9;25(1):217
Arthritis research & therapy 2023 Nov 9;25(1):217
Resatorvid alleviates experimental inflammatory TMJOA by restraining chondrocyte pyroptosis and synovial inflammation.
Liu X, Li H, Feng Y, Guo H, Li Y, Ke J, Long X
Arthritis research & therapy 2023 Nov 29;25(1):230
Arthritis research & therapy 2023 Nov 29;25(1):230
Effect of intra-articular injection of a hyaluronic acid-alendronate conjugate on post-traumatic osteoarthritis induced by destabilization of the medial meniscus in rats.
Scanu A, Luisetto R, Pavan M, Guarise C, Beninatto R, Giraudo C, Galuppini F, Lazzarin V, Guzzardo V, Pennelli G, Galesso D, Masiero S
Scientific reports 2023 Nov 24;13(1):20692
Scientific reports 2023 Nov 24;13(1):20692
Activation of the Nrf-2 pathway by pinocembrin safeguards vertebral endplate chondrocytes against apoptosis and degeneration caused by oxidative stress.
Wang H, Liu X, Yang H, Jing X, Wang W, Liu X, Zhang B, Liu X, Shao Y, Cui X
Life sciences 2023 Nov 15;333:122162
Life sciences 2023 Nov 15;333:122162
Oleanolic acid, a small-molecule natural product, inhibits ECM degeneration in osteoarthritis by regulating the Hippo/YAP and Wnt/β-catenin pathways.
Ma T, Ruan H, Lv L, Wei C, Yu Y, Jia L, Song X, Zhang J, Li Y
Food & function 2023 Nov 13;14(22):9999-10013
Food & function 2023 Nov 13;14(22):9999-10013
Docosahexaenoic acid alleviates the excessive degradation of extracellular matrix in the nucleus pulposus by reducing the content of lncRNA NEAT1 to prevent the progression of intervertebral disc degeneration.
Shang L, Ma H, Zhang X, Mao R, Ma C, Ruan Z
Clinical and experimental pharmacology & physiology 2023 May;50(5):403-414
Clinical and experimental pharmacology & physiology 2023 May;50(5):403-414
Sirt1 protects against intervertebral disc degeneration induced by 1,25-dihydroxyvitamin D insufficiency in mice by inhibiting the NF-κB inflammatory pathway.
Wang P, Yang C, Lu J, Ren Y, Goltzman D, Miao D
Journal of orthopaedic translation 2023 May;40:13-26
Journal of orthopaedic translation 2023 May;40:13-26
Gli1 depletion induces oxidative stress and apoptosis of nucleus pulposus cells via Fos in intervertebral disc degeneration.
Liu L, Zhang Y, Fu J, Ai X, Long D, Leng X, Zhang Y, Huang B, Li C, Zhou Y, Feng C
Journal of orthopaedic translation 2023 May;40:116-131
Journal of orthopaedic translation 2023 May;40:116-131
Circular RNA SLTM as a miR-421-competing endogenous RNA to mediate HMGB2 expression stimulates apoptosis and inflammation in arthritic chondrocytes.
Zhang H, Xiang X, Zhou B, Chen J, Sun Y, Zhang S, Li A, Li J
Journal of biochemical and molecular toxicology 2023 May;37(5):e23306
Journal of biochemical and molecular toxicology 2023 May;37(5):e23306
Bone mesenchymal stem cell-derived exosomes involved co-delivery and synergism effect with icariin via mussel-inspired multifunctional hydrogel for cartilage protection.
Zeng J, Sun P, Zhao Y, Fang X, Wu Z, Qi X
Asian journal of pharmaceutical sciences 2023 May;18(3):100799
Asian journal of pharmaceutical sciences 2023 May;18(3):100799
The Bcr-Abl inhibitor DCC-2036 inhibits necroptosis and ameliorates osteoarthritis by targeting RIPK1 and RIPK3 kinases.
Piao L, Wu D, Rui C, Yang Y, Liu S, Liu J, Jin Z, Zhang H, Feng X, Bai L
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 May;161:114528
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 May;161:114528
Down-regulated GAS6 impairs synovial macrophage efferocytosis and promotes obesity-associated osteoarthritis.
Yao Z, Qi W, Zhang H, Zhang Z, Liu L, Shao Y, Zeng H, Yin J, Pan H, Guo X, Liu A, Cai D, Bai X, Zhang H
eLife 2023 May 5;12
eLife 2023 May 5;12
An injectable liposome-anchored teriparatide incorporated gallic acid-grafted gelatin hydrogel for osteoarthritis treatment.
Li G, Liu S, Chen Y, Zhao J, Xu H, Weng J, Yu F, Xiong A, Udduttula A, Wang D, Liu P, Chen Y, Zeng H
Nature communications 2023 May 31;14(1):3159
Nature communications 2023 May 31;14(1):3159
Accelerated aging in articular cartilage by ZMPSTE24 deficiency leads to osteoarthritis with impaired metabolic signaling and epigenetic regulation.
Suo J, Shao R, Yang R, Wang J, Zhang Z, Wang D, Niu N, Zheng X, Zou W
Cell death & disease 2023 May 22;14(5):336
Cell death & disease 2023 May 22;14(5):336
Polydopamine-Pd nanozymes as potent ROS scavengers in combination with near-infrared irradiation for osteoarthritis treatment.
Hu H, Yang J, Zhong Y, Wang J, Cai J, Luo C, Jin Z, Gao M, He M, Zheng L
iScience 2023 May 19;26(5):106605
iScience 2023 May 19;26(5):106605
Preparation of Melatonin-Loaded Nanoparticles with Targeting and Sustained Release Function and Their Application in Osteoarthritis.
Liang H, Yan Y, Sun W, Ma X, Su Z, Liu Z, Chen Y, Yu B
International journal of molecular sciences 2023 May 14;24(10)
International journal of molecular sciences 2023 May 14;24(10)
Physalin A alleviates intervertebral disc degeneration via anti-inflammatory and anti-fibrotic effects.
Lu R, Xu H, Deng X, Wang Y, He Z, Xu S, Liang S, Huang X, You H, Guo F, Cheng P, Chen AM
Journal of orthopaedic translation 2023 Mar;39:74-87
Journal of orthopaedic translation 2023 Mar;39:74-87
hASCs-derived exosomal miR-155-5p targeting TGFβR2 promotes autophagy and reduces pyroptosis to alleviate intervertebral disc degeneration.
Chen D, Jiang X, Zou H
Journal of orthopaedic translation 2023 Mar;39:163-176
Journal of orthopaedic translation 2023 Mar;39:163-176
METTL3 promotes SMSCs chondrogenic differentiation by targeting the MMP3, MMP13, and GATA3.
Hu B, Zou X, Yu Y, Jiang Y, Xu H
Regenerative therapy 2023 Mar;22:148-159
Regenerative therapy 2023 Mar;22:148-159
The Effect of Gut Microbiota on the Progression of Intervertebral Disc Degeneration.
Yao B, Cai Y, Wang W, Deng J, Zhao L, Han Z, Wan L
Orthopaedic surgery 2023 Mar;15(3):858-867
Orthopaedic surgery 2023 Mar;15(3):858-867
Hepatic TREM2(+) macrophages express matrix metalloproteinases to control fibrotic scar formation.
Lee KJ, An S, Kim MY, Kim SM, Jeong WI, Ko HJ, Yang YM, Noh M, Han YH
Immunology and cell biology 2023 Mar;101(3):216-230
Immunology and cell biology 2023 Mar;101(3):216-230
Apigenin Inhibits the Progression of Osteoarthritis by Mediating Macrophage Polarization.
Ji X, Du W, Che W, Wang L, Zhao L
Molecules (Basel, Switzerland) 2023 Mar 24;28(7)
Molecules (Basel, Switzerland) 2023 Mar 24;28(7)
PTEN inhibitor VO-OHpic protects endplate chondrocytes against apoptosis and calcification via activating Nrf-2 signaling pathway.
Cui X, Liu X, Kong P, Du T, Li T, Yang G, Zhang W, Jing X, Wang W
Aging 2023 Mar 24;15(6):2275-2292
Aging 2023 Mar 24;15(6):2275-2292
Pan-cancer analysis reveals the associations between MMP13 high expression and carcinogenesis and its value as a serum diagnostic marker.
Zhang X, Deng Q, Wan X, Zhao J, Zheng X, Wang H, Wang HQ, Yang W
Aging 2023 Mar 22;15(6):2115-2135
Aging 2023 Mar 22;15(6):2115-2135
Therapeutic effects of kefir peptides on adjuvant-induced arthritis in rats through anti-inflammation and downregulation of matrix metalloproteinases.
Chuang KC, Lai YW, Ko CH, Yen CC, Chen HL, Lan YW, Chen CF, Chen W, Chen CM
Life sciences 2023 Mar 15;317:121411
Life sciences 2023 Mar 15;317:121411
Thermosensitive hydrogel for cartilage regeneration via synergistic delivery of SDF-1α like polypeptides and kartogenin.
Yuan X, Wan J, Yang Y, Huang L, Zhou C, Su J, Hua S, Pu H, Zou Y, Zhu H, Jiang X, Xiao J
Carbohydrate polymers 2023 Mar 15;304:120492
Carbohydrate polymers 2023 Mar 15;304:120492
ROS-responsive magnesium-containing microspheres for antioxidative treatment of intervertebral disc degeneration.
Zhang T, Wang Y, Li R, Xin J, Zheng Z, Zhang X, Xiao C, Zhang S
Acta biomaterialia 2023 Mar 1;158:475-492
Acta biomaterialia 2023 Mar 1;158:475-492
BACH1 promotes intervertebral disc degeneration by regulating HMOX1/GPX4 to mediate oxidative stress, ferroptosis, and lipid metabolism in nucleus pulposus cells.
Yao B, Cai Y, Wan L, Deng J, Zhao L, Wang W, Han Z
The journal of gene medicine 2023 Jun;25(6):e3488
The journal of gene medicine 2023 Jun;25(6):e3488
Luteolin ameliorates cornea stromal collagen degradation and inflammatory damage in rats with corneal alkali burn.
Wang H, Guo Z, Liu P, Yang X, Li Y, Lin Y, Zhao X, Liu Y
Experimental eye research 2023 Jun;231:109466
Experimental eye research 2023 Jun;231:109466
Excess Growth Hormone Triggers Inflammation-Associated Arthropathy, Subchondral Bone Loss, and Arthralgia.
Poudel SB, Ruff RR, Yildirim G, Dixit M, Michot B, Gibbs JL, Ortiz SD, Kopchick JJ, Kirsch T, Yakar S
The American journal of pathology 2023 Jun;193(6):829-842
The American journal of pathology 2023 Jun;193(6):829-842
Stevioside protects primary articular chondrocytes against IL-1β-induced inflammation and catabolism by targeting integrin.
Wan J, Zhu Z, He Z, Wu H, Chen A, Zhu W, Cheng P
International immunopharmacology 2023 Jun;119:110261
International immunopharmacology 2023 Jun;119:110261
Astaxanthin suppresses oxidative stress and calcification in vertebral cartilage endplate via activating Nrf-2/HO-1 signaling pathway.
Yang G, Liu X, Jing X, Wang J, Wang H, Chen F, Wang W, Shao Y, Cui X
International immunopharmacology 2023 Jun;119:110159
International immunopharmacology 2023 Jun;119:110159
Isobavachalcone ameliorates the progression of osteoarthritis by suppressing NF-κB signaling pathway.
Guo Q, Zhang M, Dong Y, Liu K, Wang D, Zheng J
International immunopharmacology 2023 Jun;119:110102
International immunopharmacology 2023 Jun;119:110102
ADSCs increase the autophagy of chondrocytes through decreasing miR-7-5p in Osteoarthritis rats by targeting ATG4A.
Zhao S, Liu Y, Wang J, Wen Y, Wu B, Yang D, Wang G, Xiu G, Ling B, Du D, Xu J
International immunopharmacology 2023 Jul;120:110390
International immunopharmacology 2023 Jul;120:110390
Suramin ameliorates osteoarthritis by acting on the Nrf2/HO-1 and NF-κB signaling pathways in chondrocytes and promoting M2 polarization in macrophages.
Shen PC, Huang SH, Liu ZM, Lu CC, Chou SH, Tien YC
International immunopharmacology 2023 Jul;120:110295
International immunopharmacology 2023 Jul;120:110295
SIRT5-related desuccinylation modification of AIFM1 protects against compression-induced intervertebral disc degeneration by regulating mitochondrial homeostasis.
Mao J, Wang D, Wang D, Wu Q, Shang Q, Gao C, Wang H, Wang H, Du M, Peng P, Jia H, Xu X, Wang J, Yang L, Luo Z
Experimental & molecular medicine 2023 Jan;55(1):253-268
Experimental & molecular medicine 2023 Jan;55(1):253-268
Novel insights into the effect of deer IGF-1 on chondrocyte viability and IL-1β-induced inflammation response.
Zhong J, Zhang J, Zhou Z, Pan D, Zhao D, Dong H, Yao B
Journal of biochemical and molecular toxicology 2023 Jan;37(1):e23227
Journal of biochemical and molecular toxicology 2023 Jan;37(1):e23227
miR-140-5p protects cartilage progenitor/stem cells from fate changes in knee osteoarthritis.
Chen Y, Huang H, Zhong W, Li L, Lu Y, Si HB
International immunopharmacology 2023 Jan;114:109576
International immunopharmacology 2023 Jan;114:109576
Methyl gallate prevents oxidative stress induced apoptosis and ECM degradation in chondrocytes via restoring Sirt3 mediated autophagy and ameliorates osteoarthritis progression.
Li Y, Shen B, Lv C, Zhu X, Naren Q, Xu D, Chen H, Wu F
International immunopharmacology 2023 Jan;114:109489
International immunopharmacology 2023 Jan;114:109489
Transglutaminase 2 inhibitors attenuate osteoarthritic degeneration of TMJ-osteoarthritis by suppressing NF-κB activation.
Li Y, Sun H, Liu X, Hu Z, Jiang H, Guo H, Long X
International immunopharmacology 2023 Jan;114:109486
International immunopharmacology 2023 Jan;114:109486
Knockdown of LINC01138 protects human chondrocytes against IL-1β-induced damage by regulating the hsa-miR-1207-5p/KIAA0101 axis.
Zhang J, Lv G
Immunity, inflammation and disease 2023 Jan;11(1):e744
Immunity, inflammation and disease 2023 Jan;11(1):e744
N-acetylglucosamine-bearing polymers mimicking O-GlcNAc-modified proteins elicit anti-fibrotic activities in myofibroblasts and activated stellate cells.
Ise H, Araki Y, Song I, Akatsuka G
Glycobiology 2023 Jan 8;33(1):17-37
Glycobiology 2023 Jan 8;33(1):17-37
Indole-3-propionic acid alleviates chondrocytes inflammation and osteoarthritis via the AhR/NF-κB axis.
Zhuang H, Ren X, Jiang F, Zhou P
Molecular medicine (Cambridge, Mass.) 2023 Jan 31;29(1):17
Molecular medicine (Cambridge, Mass.) 2023 Jan 31;29(1):17
LncRNA WDR11-AS1 Promotes Extracellular Matrix Synthesis in Osteoarthritis by Directly Interacting with RNA-Binding Protein PABPC1 to Stabilize SOX9 Expression.
Huang H, Yan J, Lan X, Guo Y, Sun M, Zhao Y, Zhang F, Sun J, Lu S
International journal of molecular sciences 2023 Jan 3;24(1)
International journal of molecular sciences 2023 Jan 3;24(1)
Ginsenoside Compound K Ameliorates Osteoarthritis by Inhibiting the Chondrocyte Endoplasmic Reticulum Stress-Mediated IRE1α-TXNIP-NLRP3 Axis and Pyroptosis.
Tian Y, Feng X, Zhou Z, Qin S, Chen S, Zhao J, Hou J, Liu D
Journal of agricultural and food chemistry 2023 Jan 25;71(3):1499-1509
Journal of agricultural and food chemistry 2023 Jan 25;71(3):1499-1509
Dendrobine Alleviates Cellular Senescence and Osteoarthritis via the ROS/NF-κB Axis.
Chen H, Tu M, Liu S, Wen Y, Chen L
International journal of molecular sciences 2023 Jan 25;24(3)
International journal of molecular sciences 2023 Jan 25;24(3)
Inhibition of Klf10 Attenuates Oxidative Stress-Induced Senescence of Chondrocytes via Modulating Mitophagy.
Shang J, Lin N, Peng R, Jiang N, Wu B, Xing B, Lin S, Xu X, Lu H
Molecules (Basel, Switzerland) 2023 Jan 17;28(3)
Molecules (Basel, Switzerland) 2023 Jan 17;28(3)
Targeting TRMT5 suppresses hepatocellular carcinoma progression via inhibiting the HIF-1α pathways.
Zhao Q, Zhang L, He Q, Chang H, Wang Z, Cao H, Zhou Y, Pan R, Chen Y
Journal of Zhejiang University. Science. B 2023 Jan 15;24(1):50-63
Journal of Zhejiang University. Science. B 2023 Jan 15;24(1):50-63
Type 1 diabetes mellitus leads to gingivitis and an early compensatory increase in bone remodeling.
Yuan X, Amin V, Zhu T, Kittaka M, Ueki Y, Bellido TM, Turkkahraman H
Journal of periodontology 2023 Feb;94(2):277-289
Journal of periodontology 2023 Feb;94(2):277-289
Hypoxia-Inducible Factor-1α Protects Against Intervertebral Disc Degeneration Through Antagonizing Mitochondrial Oxidative Stress.
Yang W, Jia C, Liu L, Fu Y, Wu Y, Liu Z, Yu R, Ma X, Gong A, Liu F, Xia Y, Hou Y, Li Y, Zhang L
Inflammation 2023 Feb;46(1):270-284
Inflammation 2023 Feb;46(1):270-284
Cyasterone inhibits IL-1β-mediated apoptosis and inflammation via the NF-κB and MAPK signaling pathways in rat chondrocytes and ameliorates osteoarthritisin vivo.
Teng L, Shen Y, Qu Y, Yang L, Yang Y, Jian X, Fan S, Zhang L, Fu Q
Chinese journal of natural medicines 2023 Feb;21(2):99-112
Chinese journal of natural medicines 2023 Feb;21(2):99-112
Platelet-derived extracellular vesicles ameliorate intervertebral disc degeneration by alleviating mitochondrial dysfunction.
Dai Z, Xia C, Zhao T, Wang H, Tian H, Xu O, Zhu X, Zhang J, Chen P
Materials today. Bio 2023 Feb;18:100512
Materials today. Bio 2023 Feb;18:100512
Analyses of Transcriptomics upon IL-1β-Stimulated Mouse Chondrocytes and the Protective Effect of Catalpol through the NOD2/NF-κB/MAPK Signaling Pathway.
Pang Y, Zhao L, Ji X, Guo K, Yin X
Molecules (Basel, Switzerland) 2023 Feb 7;28(4)
Molecules (Basel, Switzerland) 2023 Feb 7;28(4)
Mulberroside A alleviates osteoarthritis via restoring impaired autophagy and suppressing MAPK/NF-κB/PI3K-AKT-mTOR signaling pathways.
Lu R, Wei Z, Wang Z, Xu S, Sun K, Cheng P, Huang X, You H, Guo F, Liang S, Chen AM
iScience 2023 Feb 17;26(2):105936
iScience 2023 Feb 17;26(2):105936
Matrix Stiffness Activating YAP/TEAD1-Cyclin B1 in Nucleus Pulposus Cells Promotes Intervertebral Disc Degeneration.
Zhou Z, Suo Y, Bai J, Lin F, Gao X, Shan H, Ni Y, Zhou X, Sheng L, Dai J
Aging and disease 2023 Feb 11;
Aging and disease 2023 Feb 11;
Treadmill Exercise Suppresses Histological Progression of Disuse Atrophy in Articular Cartilage in Rat Knee Joints during Hindlimb Suspension.
Takahashi I, Matsuzaki T, Kuroki H, Hoso M
Cartilage 2023 Dec;14(4):482-491
Cartilage 2023 Dec;14(4):482-491
FUNDC1/PFKP-mediated mitophagy induced by KD025 ameliorates cartilage degeneration in osteoarthritis.
Fang G, Wen X, Jiang Z, Du X, Liu R, Zhang C, Huang G, Liao W, Zhang Z
Molecular therapy : the journal of the American Society of Gene Therapy 2023 Dec 6;31(12):3594-3612
Molecular therapy : the journal of the American Society of Gene Therapy 2023 Dec 6;31(12):3594-3612
MiR-146b-5p enriched bioinspired exosomes derived from fucoidan-directed induction mesenchymal stem cells protect chondrocytes in osteoarthritis by targeting TRAF6.
Lou C, Jiang H, Lin Z, Xia T, Wang W, Lin C, Zhang Z, Fu H, Iqbal S, Liu H, Lin J, Wang J, Pan X, Xue X
Journal of nanobiotechnology 2023 Dec 18;21(1):486
Journal of nanobiotechnology 2023 Dec 18;21(1):486
MiR-203a-3p attenuates apoptosis and pyroptosis of chondrocytes by regulating the MYD88/NF-κB pathway to alleviate osteoarthritis progression.
Chen J, Liu Z, Sun H, Liu M, Wang J, Zheng C, Cao X
Aging 2023 Dec 13;15(23):14457-14472
Aging 2023 Dec 13;15(23):14457-14472
Hsa_circ_0001946 Ameliorates Mechanical Stress-induced Intervertebral Disk Degeneration Via Targeting miR-432-5p and SOX9.
Xiang Q, Wang J, Cheng Z, Zhao K, Gan W, Chen Y, Zhang Y
Spine 2023 Dec 1;48(23):E401-E408
Spine 2023 Dec 1;48(23):E401-E408
Bauhinia championii alleviates extracellular matrix degradation in IL-1β induced chondrocytes via miRNA-145-5p/TLR4/NF-κB axis.
Lin J, Huang Y, Lin X, Liu W, Wu X, Qiu H, Wang R
Heliyon 2023 Aug;9(8):e19138
Heliyon 2023 Aug;9(8):e19138
Ginsenoside compound K alleviates osteoarthritis by inhibiting NLRP3‑mediated pyroptosis.
Li Y, Wu J, Zhuo N
Experimental and therapeutic medicine 2023 Aug;26(2):406
Experimental and therapeutic medicine 2023 Aug;26(2):406
YY1/miR-140-5p/Jagged1/Notch axis mediates cartilage progenitor/stem cells fate reprogramming in knee osteoarthritis.
Chen Y, Liao G, Ma T, Li L, Yang J, Shen B, Lu Y, Si H
International immunopharmacology 2023 Aug;121:110438
International immunopharmacology 2023 Aug;121:110438
ROR1/STAT3 positive feedback loop facilitates cartilage degeneration in Osteoarthritis through activation of NF-κB signaling pathway.
Huang W, Tang H, Liu Y, Li W, Shimu AS, Li B, Zhu C
International immunopharmacology 2023 Aug;121:110433
International immunopharmacology 2023 Aug;121:110433
Induced skin aging by blue-light irradiation in human skin fibroblasts via TGF-β, JNK and EGFR pathways.
Ge G, Wang Y, Xu Y, Pu W, Tan Y, Liu P, Ding H, Lu YM, Wang J, Liu W, Ma Y
Journal of dermatological science 2023 Aug;111(2):52-59
Journal of dermatological science 2023 Aug;111(2):52-59
Adseverin, an actin-binding protein, modulates hypertrophic chondrocyte differentiation and osteoarthritis progression.
Chan B, Glogauer M, Wang Y, Wrana J, Chan K, Beier F, Bali S, Hinz B, Parreno J, Ashraf S, Kandel R
Science advances 2023 Aug 4;9(31):eadf1130
Science advances 2023 Aug 4;9(31):eadf1130
ADRM1/RPN13 attenuates cartilage extracellular matrix degradation via enhancing UCH37-mediated ALK5 deubiquitination.
Zhu M, Cao Z, Mo F, Shi S, Hu J, Xu Q, Quan K, Liang J, Li W, Hong X, Zhang B, Liu X, Dai M
International journal of biological macromolecules 2023 Aug 30;247:125670
International journal of biological macromolecules 2023 Aug 30;247:125670
Injectable photocrosslinking spherical hydrogel-encapsulated targeting peptide-modified engineered exosomes for osteoarthritis therapy.
Wan J, He Z, Peng R, Wu X, Zhu Z, Cui J, Hao X, Chen A, Zhang J, Cheng P
Journal of nanobiotechnology 2023 Aug 21;21(1):284
Journal of nanobiotechnology 2023 Aug 21;21(1):284
Skin Extracellular Matrix Breakdown Following Paclitaxel Therapy in Patients with Chemotherapy-Induced Peripheral Neuropathy.
Staff NP, Hrstka SC, Dasari S, Capobianco E, Rieger S
Cancers 2023 Aug 21;15(16)
Cancers 2023 Aug 21;15(16)
WITHDRAWN: Expression of Tmem41b and MMP13 associated with poor outcome in osteosarcomas.
Li GH, Liu X, Feng LJ, Zhang L
Neoplasma 2023 Aug 20;
Neoplasma 2023 Aug 20;
Hederagenin Suppresses Inflammation and Cartilage Degradation to Ameliorate the Progression of Osteoarthritis: An In vivo and In vitro Study.
Shen Y, Teng L, Qu Y, Huang Y, Peng Y, Tang M, Fu Q
Inflammation 2023 Apr;46(2):655-678
Inflammation 2023 Apr;46(2):655-678
Intra-articular treatment of temporomandibular joint osteoarthritis by injecting actively-loaded meloxicam liposomes with dual-functions of anti-inflammation and lubrication.
Zhong Y, Zhou Y, Ding R, Zou L, Zhang H, Wei X, He D
Materials today. Bio 2023 Apr;19:100573
Materials today. Bio 2023 Apr;19:100573
Cardamonin alleviates chondrocytes inflammation and cartilage degradation of osteoarthritis by inhibiting ferroptosis via p53 pathway.
Gong Z, Wang Y, Li L, Li X, Qiu B, Hu Y
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Apr;174:113644
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Apr;174:113644
Integrated Cascade Nanozyme Remodels Chondrocyte Inflammatory Microenvironment in Temporomandibular Joint Osteoarthritis via Inhibiting ROS-NF-κB and MAPK Pathways.
Zhang Z, Yuan L, Liu Y, Wang R, Zhang Y, Yang Y, Wei H, Ma J
Advanced healthcare materials 2023 Apr;12(10):e2203195
Advanced healthcare materials 2023 Apr;12(10):e2203195
Dihydrocaffeic acid improves IL-1β-induced inflammation and cartilage degradation via inhibiting NF-κB and MAPK signalling pathways.
Lu R, Wang YG, Qu Y, Wang SX, Peng C, You H, Zhu W, Chen A
Bone & joint research 2023 Apr 6;12(4):259-273
Bone & joint research 2023 Apr 6;12(4):259-273
Maintaining hypoxia environment of subchondral bone alleviates osteoarthritis progression.
Zhang H, Wang L, Cui J, Wang S, Han Y, Shao H, Wang C, Hu Y, Li X, Zhou Q, Guo J, Zhuang X, Sheng S, Zhang T, Zhou D, Chen J, Wang F, Gao Q, Jing Y, Chen X, Su J
Science advances 2023 Apr 5;9(14):eabo7868
Science advances 2023 Apr 5;9(14):eabo7868
Monotropein attenuates apoptosis and pyroptosis in chondrocytes and alleviates osteoarthritis progression in mice.
Li Z, Chen Z, Chen J, Liu Z, Li Z, Sun H, Wang X, Wei J, Cao X, Zheng D
Chinese medicine 2023 Apr 19;18(1):42
Chinese medicine 2023 Apr 19;18(1):42
Dioscin alleviates the progression of osteoarthritis: an in vitro and in vivo study.
Ding Q, Zhang R, Sheng G, Wang T, Jing S, Ma T, Wang S, Zhao H, Wu H, Li W
Journal of inflammation (London, England) 2023 Apr 13;20(1):14
Journal of inflammation (London, England) 2023 Apr 13;20(1):14
Natural product, bilobalide, improves joint health in rabbits with osteoarthritis by anti-matrix degradation and antioxidant activities.
Ma T, Chen H, Ruan H, Lv L, Yu Y, Jia L, Zhao J, Li X, Zang Y, Xu X, Zhang J, Gao L
Frontiers in veterinary science 2022;9:1034623
Frontiers in veterinary science 2022;9:1034623
Gastrocnemius Muscle Injury Is the Condition to Induce Cartilage Degeneration of the Rabbit Tibiofemoral Joint: A New Perspective.
Li Y, Sun J, Hou Y, Wei J, Chai Y, Zhu X, Wang R
BioMed research international 2022;2022:7532434
BioMed research international 2022;2022:7532434
Selenium Attenuates TBHP-Induced Apoptosis of Nucleus Pulposus Cells by Suppressing Mitochondrial Fission through Activating Nuclear Factor Erythroid 2-Related Factor 2.
Wang P, Zhang S, Liu W, Chen S, Lv X, Hu B, Shao Z
Oxidative medicine and cellular longevity 2022;2022:7531788
Oxidative medicine and cellular longevity 2022;2022:7531788
Cyclic Polypeptide D7 Protects Bone Marrow Mesenchymal Cells and Promotes Chondrogenesis during Osteonecrosis of the Femoral Head via Growth Differentiation Factor 15-Mediated Redox Signaling.
Chen J, Cui Z, Wang Y, Lyu L, Feng C, Feng D, Cheng Y, Li Z, Sun S
Oxidative medicine and cellular longevity 2022;2022:3182368
Oxidative medicine and cellular longevity 2022;2022:3182368
Theaflavin-3,3'-Digallate Protects Cartilage from Degradation by Modulating Inflammation and Antioxidant Pathways.
Teng Y, Jin Z, Ren W, Lu M, Hou M, Zhou Q, Wang W, Yang H, Zou J
Oxidative medicine and cellular longevity 2022;2022:3047425
Oxidative medicine and cellular longevity 2022;2022:3047425
Oxymatrine Protects Chondrocytes against IL-1β-triggered Apoptosis in Vitro and Inhibits Osteoarthritis in Mice Model.
Mohetaer D, Cao L, Wang Y
Evidence-based complementary and alternative medicine : eCAM 2022;2022:2745946
Evidence-based complementary and alternative medicine : eCAM 2022;2022:2745946
Corynoline Alleviates Osteoarthritis Development via the Nrf2/NF-κB Pathway.
Li S, Shi Y, Zhang S, Li H, Ye Z, Kong J, Hong W, Tu Y, Ren J, Meftah Z, Xie C, Wang X, Zhang X
Oxidative medicine and cellular longevity 2022;2022:2188145
Oxidative medicine and cellular longevity 2022;2022:2188145
Silencing of Angiopoietin-Like Protein 4 (Angptl4) Decreases Inflammation, Extracellular Matrix Degradation, and Apoptosis in Osteoarthritis via the Sirtuin 1/NF-κB Pathway.
Jia C, Li X, Pan J, Ma H, Wu D, Lu H, Wang W, Zhang X, Yi X
Oxidative medicine and cellular longevity 2022;2022:1135827
Oxidative medicine and cellular longevity 2022;2022:1135827
Spheroid Formation Enhances the Regenerative Capacity of Nucleus Pulposus Cells via Regulating N-CDH and ITGβ1 Interaction.
Wang Y, Wang H, Zhuo Y, Hu Y, Li X, Xu Y, Sun B, Liu M, Zou L, Liu L, Luo L, Zhao C, Li P, Zhou Q
International journal of biological sciences 2022;18(9):3676-3696
International journal of biological sciences 2022;18(9):3676-3696
Corosolic Acid Protects Rat Chondrocytes Against IL-1β-Induced ECM Degradation by Activating Autophagy via PI3K/AKT/mTOR Pathway and Ameliorates Rat Osteoarthritis.
Han H, Chen M, Li Z, Zhou S, Wu Y, Wei J
Drug design, development and therapy 2022;16:2627-2637
Drug design, development and therapy 2022;16:2627-2637
3,3'-diindolylmethane inhibits LPS-induced human chondrocytes apoptosis and extracellular matrix degradation by activating PI3K-Akt-mTOR-mediated autophagy.
Tang H, Qin K, Wang A, Li S, Fang S, Gao W, Lu M, Huang W, Zhang H, Yin Z
Frontiers in pharmacology 2022;13:999851
Frontiers in pharmacology 2022;13:999851
NRF2-directed PRPS1 upregulation to promote the progression and metastasis of melanoma.
Xiong G, Feng Y, Yi X, Zhang X, Li X, Yang L, Yi Z, Sai B, Yang Z, Zhang Q, Kuang Y, Zhu Y
Frontiers in immunology 2022;13:989263
Frontiers in immunology 2022;13:989263
Omaveloxolone inhibits IL-1β-induced chondrocyte apoptosis through the Nrf2/ARE and NF-κB signalling pathways in vitro and attenuates osteoarthritis in vivo.
Jiang Z, Qi G, Lu W, Wang H, Li D, Chen W, Ding L, Yang X, Yuan H, Zeng Q
Frontiers in pharmacology 2022;13:952950
Frontiers in pharmacology 2022;13:952950
Icariin protects vertebral endplate chondrocytes against apoptosis and degeneration via activating Nrf-2/HO-1 pathway.
Shao Y, Sun L, Yang G, Wang W, Liu X, Du T, Chen F, Jing X, Cui X
Frontiers in pharmacology 2022;13:937502
Frontiers in pharmacology 2022;13:937502
The Protective Effect of Evodiamine in Osteoarthritis: An In Vitro and In Vivo Study in Mice Model.
Xian S, Lin Z, Zhou C, Wu X
Frontiers in pharmacology 2022;13:899108
Frontiers in pharmacology 2022;13:899108
Cepharanthine Ameliorates Chondrocytic Inflammation and Osteoarthritis via Regulating the MAPK/NF-κB-Autophagy Pathway.
Yao M, Zhang C, Ni L, Ji X, Hong J, Chen Y, Wang J, Li C, Lin J, Lu T, Sheng Y, Sun M, Shi M, Zhou C, Cai X
Frontiers in pharmacology 2022;13:854239
Frontiers in pharmacology 2022;13:854239
Saikosaponin D Inhibited IL-1β Induced ATDC 5 Chondrocytes Apoptosis In Vitro and Delayed Articular Cartilage Degeneration in OA Model Mice In Vivo.
Wu X, Zhao K, Fang X, Lu F, Cheng P, Song X, Zhang W, Yao C, Zhu J, Chen H
Frontiers in pharmacology 2022;13:845959
Frontiers in pharmacology 2022;13:845959
Deferoxamine Alleviates Osteoarthritis by Inhibiting Chondrocyte Ferroptosis and Activating the Nrf2 Pathway.
Guo Z, Lin J, Sun K, Guo J, Yao X, Wang G, Hou L, Xu J, Guo J, Guo F
Frontiers in pharmacology 2022;13:791376
Frontiers in pharmacology 2022;13:791376
Oroxin B alleviates osteoarthritis through anti-inflammation and inhibition of PI3K/AKT/mTOR signaling pathway and enhancement of autophagy.
Lu R, He Z, Zhang W, Wang Y, Cheng P, Lv Z, Yuan X, Guo F, You H, Chen AM, Hu W
Frontiers in endocrinology 2022;13:1060721
Frontiers in endocrinology 2022;13:1060721
XMU-MP-1 attenuates osteoarthritis via inhibiting cartilage degradation and chondrocyte apoptosis.
Hao X, Zhao J, Jia L, He T, Wang H, Fan J, Yang Y, Su F, Lu Q, Zheng C, Yang L, Jie Q
Frontiers in bioengineering and biotechnology 2022;10:998077
Frontiers in bioengineering and biotechnology 2022;10:998077
Enhancing autophagy and energy metabolism in the meniscus can delay the occurrence of PTOA in ACLT rat.
Zhu H, Liu H, Chen X, Xu X, Zhang S, Xie D
Frontiers in cell and developmental biology 2022;10:971736
Frontiers in cell and developmental biology 2022;10:971736
Flavokawain A alleviates the progression of mouse osteoarthritis: An in vitro and in vivo study.
Jing S, Wan J, Wang T, He Z, Ding Q, Sheng G, Wang S, Zhao H, Zhu Z, Wu H, Li W
Frontiers in bioengineering and biotechnology 2022;10:1071776
Frontiers in bioengineering and biotechnology 2022;10:1071776
Hyaluronic acid ameliorates intervertebral disc degeneration via promoting mitophagy activation.
Zhang F, Wang S, Gao M, Li B, He Z, Tang T, Zhu Z, Liu S, Zhou Z
Frontiers in bioengineering and biotechnology 2022;10:1057429
Frontiers in bioengineering and biotechnology 2022;10:1057429
Transcriptomic analysis supports collective endometrial cell migration in the pathogenesis of adenomyosis.
Zhai J, Li S, Sen S, Vallvé-Juanico J, Irwin JC, Vo KC, Wan J, Du Y, Chen ZJ, Giudice LC
Reproductive biomedicine online 2022 Sep;45(3):519-530
Reproductive biomedicine online 2022 Sep;45(3):519-530
CD40/TRAF1 decreases synovial cell apoptosis in patients with rheumatoid arthritis through JNK/NF-κB pathway.
Cheng T, Wu J, Xu Y, Liu C, Zhang H, Wang M
Journal of bone and mineral metabolism 2022 Sep;40(5):819-828
Journal of bone and mineral metabolism 2022 Sep;40(5):819-828
Iron overload promotes intervertebral disc degeneration via inducing oxidative stress and ferroptosis in endplate chondrocytes.
Wang W, Jing X, Du T, Ren J, Liu X, Chen F, Shao Y, Sun S, Yang G, Cui X
Free radical biology & medicine 2022 Sep;190:234-246
Free radical biology & medicine 2022 Sep;190:234-246
Nanosilicate-Reinforced Silk Fibroin Hydrogel for Endogenous Regeneration of Both Cartilage and Subchondral Bone.
Sheng R, Chen J, Wang H, Luo Y, Liu J, Chen Z, Mo Q, Chi J, Ling C, Tan X, Yao Q, Zhang W
Advanced healthcare materials 2022 Sep;11(17):e2200602
Advanced healthcare materials 2022 Sep;11(17):e2200602
Magnoflorine attenuates inflammatory responses in RA by regulating the PI3K/Akt/NF-κB and Keap1-Nrf2/HO-1 signalling pathways in vivo and in vitro.
Shen Y, Fan X, Qu Y, Tang M, Huang Y, Peng Y, Fu Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Sep;104:154339
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Sep;104:154339
Omentin-1 promoted proliferation and ameliorated inflammation, apoptosis, and degeneration in human nucleus pulposus cells.
Cabral VLF, Wang F, Peng X, Gao J, Zhou Z, Sun R, Bao J, Wu X
Archives of gerontology and geriatrics 2022 Sep-Oct;102:104748
Archives of gerontology and geriatrics 2022 Sep-Oct;102:104748
Vasorin-containing small extracellular vesicles retard intervertebral disc degeneration utilizing an injectable thermoresponsive delivery system.
Liao Z, Ke W, Liu H, Tong B, Wang K, Feng X, Hua W, Wang B, Song Y, Luo R, Liang H, Zhang W, Zhao K, Li S, Yang C
Journal of nanobiotechnology 2022 Sep 19;20(1):420
Journal of nanobiotechnology 2022 Sep 19;20(1):420
ALPK1 Accelerates the Pathogenesis of Osteoarthritis by Activating NLRP3 Signaling.
Liu X, Zhao J, Jiang H, Guo H, Li Y, Li H, Feng Y, Ke J, Long X
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2022 Oct;37(10):1973-1985
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2022 Oct;37(10):1973-1985
Chicoric acid attenuates tumor necrosis factor-α-induced inflammation and apoptosis via the Nrf2/HO-1, PI3K/AKT and NF-κB signaling pathways in C28/I2 cells and ameliorates the progression of osteoarthritis in a rat model.
Qu Y, Shen Y, Teng L, Huang Y, Yang Y, Jian X, Fan S, Wu P, Fu Q
International immunopharmacology 2022 Oct;111:109129
International immunopharmacology 2022 Oct;111:109129
Self-amplifying loop of NF-κB and periostin initiated by PIEZO1 accelerates mechano-induced senescence of nucleus pulposus cells and intervertebral disc degeneration.
Wu J, Chen Y, Liao Z, Liu H, Zhang S, Zhong D, Qiu X, Chen T, Su D, Ke X, Wan Y, Zhou T, Su P
Molecular therapy : the journal of the American Society of Gene Therapy 2022 Oct 5;30(10):3241-3256
Molecular therapy : the journal of the American Society of Gene Therapy 2022 Oct 5;30(10):3241-3256
Calycosin mitigates chondrocyte inflammation and apoptosis by inhibiting the PI3K/AKT and NF-κB pathways.
Shi X, Jie L, Wu P, Zhang N, Mao J, Wang P, Yin S
Journal of ethnopharmacology 2022 Oct 28;297:115536
Journal of ethnopharmacology 2022 Oct 28;297:115536
Runx2 and Runx3 differentially regulate articular chondrocytes during surgically induced osteoarthritis development.
Nagata K, Hojo H, Chang SH, Okada H, Yano F, Chijimatsu R, Omata Y, Mori D, Makii Y, Kawata M, Kaneko T, Iwanaga Y, Nakamoto H, Maenohara Y, Tachibana N, Ishikura H, Higuchi J, Taniguchi Y, Ohba S, Chung UI, Tanaka S, Saito T
Nature communications 2022 Oct 19;13(1):6187
Nature communications 2022 Oct 19;13(1):6187
Astaxanthin attenuates osteoarthritis progression via inhibiting ferroptosis and regulating mitochondrial function in chondrocytes.
Wang X, Liu Z, Peng P, Gong Z, Huang J, Peng H
Chemico-biological interactions 2022 Oct 1;366:110148
Chemico-biological interactions 2022 Oct 1;366:110148
Dual-dynamic-bond cross-linked injectable hydrogel of multifunction for intervertebral disc degeneration therapy.
Yang L, Yu C, Fan X, Zeng T, Yang W, Xia J, Wang J, Yao L, Hu C, Jin Y, Zhu Y, Chen J, Hu Z
Journal of nanobiotechnology 2022 Oct 1;20(1):433
Journal of nanobiotechnology 2022 Oct 1;20(1):433
Caffeic acid phenethyl ester attenuates osteoarthritis progression by activating NRF2/HO‑1 and inhibiting the NF‑κB signaling pathway.
Sun W, Xie W, Huang D, Cui Y, Yue J, He Q, Jiang L, Xiong J, Sun W, Yi Q
International journal of molecular medicine 2022 Nov;50(5)
International journal of molecular medicine 2022 Nov;50(5)
Selenium-sensitive histone deacetylase 2 is required for forkhead box O3A and regulates extracellular matrix metabolism in cartilage.
Zhao Y, Guo Y, Sun M, Hussion S, Zheng Y, Huang H, Huo X, Zhao Y, Zhang F, Han Y, Ning Q, Xu P, Sun J, Lu S
Journal of bone and mineral metabolism 2022 Nov;40(6):914-926
Journal of bone and mineral metabolism 2022 Nov;40(6):914-926
LncRNA TM1-3P Regulates Proliferation, Apoptosis and Inflammation of Fibroblasts in Osteoarthritis through miR-144-3p/ONECUT2 Axis.
Yi Y, Yang N, Yang Z, Tao X, Li Y
Orthopaedic surgery 2022 Nov;14(11):3078-3091
Orthopaedic surgery 2022 Nov;14(11):3078-3091
ALPK1 Aggravates TMJOA Cartilage Degradation via NF-κB and ERK1/2 Signaling.
Liu X, Zhao J, Jiang H, Li H, Feng Y, Ke J, Long X
Journal of dental research 2022 Nov;101(12):1499-1509
Journal of dental research 2022 Nov;101(12):1499-1509
Carbon dots derived from folic acid attenuates osteoarthritis by protecting chondrocytes through NF-κB/MAPK pathway and reprogramming macrophages.
Jin Y, Zhang Q, Qin X, Liu Z, Li Z, Zhong X, Xia L, He J, Fang B
Journal of nanobiotechnology 2022 Nov 3;20(1):469
Journal of nanobiotechnology 2022 Nov 3;20(1):469
Gaseous signal molecule SO(2) regulates autophagy through PI3K/AKT pathway inhibits cardiomyocyte apoptosis and improves myocardial fibrosis in rats with type II diabetes.
Zhao J, Wu Q, Yang T, Nie L, Liu S, Zhou J, Chen J, Jiang Z, Xiao T, Yang J, Chu C
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2022 Nov 1;26(6):541-556
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2022 Nov 1;26(6):541-556
Piceatannol suppresses inflammation and promotes apoptosis in rheumatoid arthritis‑fibroblast‑like synoviocytes by inhibiting the NF‑κB and MAPK signaling pathways.
Gao X, Kang X, Lu H, Xue E, Chen R, Pan J, Ma J
Molecular medicine reports 2022 May;25(5)
Molecular medicine reports 2022 May;25(5)
Intra-articular injection of a novel Wnt pathway inhibitor, SM04690, upregulates Wnt16 expression and reduces disease progression in temporomandibular joint osteoarthritis.
Hua B, Qiu J, Ye X, Liu X
Bone 2022 May;158:116372
Bone 2022 May;158:116372
Dual functions of microRNA-17 in maintaining cartilage homeostasis and protection against osteoarthritis.
Zhang Y, Li S, Jin P, Shang T, Sun R, Lu L, Guo K, Liu J, Tong Y, Wang J, Liu S, Wang C, Kang Y, Zhu W, Wang Q, Zhang X, Yin F, Sun YE, Cui L
Nature communications 2022 May 4;13(1):2447
Nature communications 2022 May 4;13(1):2447
Asporin regulated by miR-26b-5p mediates chondrocyte senescence and exacerbates osteoarthritis progression via TGF-β1/Smad2 pathway.
Liu L, Zhao C, Zhang H, Lu Y, Luo B, Yao Z, Shao Y, Zeng H, Zeng C, Zhang R, Fang H, Pan J, Bai X, Cai D
Rheumatology (Oxford, England) 2022 May 30;61(6):2631-2643
Rheumatology (Oxford, England) 2022 May 30;61(6):2631-2643
TGF-β1 regulates chondrocyte proliferation and extracellular matrix synthesis via circPhf21a-Vegfa axis in osteoarthritis.
Lin S, Li H, Wu B, Shang J, Jiang N, Peng R, Xing B, Xu X, Lu H
Cell communication and signaling : CCS 2022 May 30;20(1):75
Cell communication and signaling : CCS 2022 May 30;20(1):75
The lncRNA PILA promotes NF-κB signaling in osteoarthritis by stimulating the activity of the protein arginine methyltransferase PRMT1.
Tang S, Cao Y, Cai Z, Nie X, Ruan J, Zhou Z, Ruan G, Zhu Z, Han W, Ding C
Science signaling 2022 May 24;15(735):eabm6265
Science signaling 2022 May 24;15(735):eabm6265
Exosomes-derived miR-125-5p from cartilage endplate stem cells regulates autophagy and ECM metabolism in nucleus pulposus by targeting SUV38H1.
Chen D, Jiang X
Experimental cell research 2022 May 1;414(1):113066
Experimental cell research 2022 May 1;414(1):113066
Paeoniflorin inhibits pyroptosis of nucleus pulposus cells in an acidic environment and alleviates the degeneration of the intervertebral disc in rats.
Dai WY, Luo ZP
Cellular signalling 2022 Mar;91:110243
Cellular signalling 2022 Mar;91:110243
HSP70 attenuates compression-induced apoptosis of nucleus pulposus cells by suppressing mitochondrial fission via upregulating the expression of SIRT3.
Hu B, Wang P, Zhang S, Liu W, Lv X, Shi D, Zhao L, Liu H, Wang B, Chen S, Shao Z
Experimental & molecular medicine 2022 Mar;54(3):309-323
Experimental & molecular medicine 2022 Mar;54(3):309-323
Oxidative stress-induced circKIF18A downregulation impairs MCM7-mediated anti-senescence in intervertebral disc degeneration.
Wang J, Xia D, Lin Y, Xu W, Wu Y, Chen J, Chu J, Shen P, Weng S, Wang X, Shen L, Fan S, Shen S
Experimental & molecular medicine 2022 Mar;54(3):285-297
Experimental & molecular medicine 2022 Mar;54(3):285-297
Regulation of osteoarthritis development by ADAM17/Tace in articular cartilage.
Kaneko T, Horiuchi K, Chijimatsu R, Mori D, Nagata K, Omata Y, Yano F, Inui H, Moro T, Tanaka S, Saito T
Journal of bone and mineral metabolism 2022 Mar;40(2):196-207
Journal of bone and mineral metabolism 2022 Mar;40(2):196-207
Use of mesoporous polydopamine nanoparticles as a stable drug-release system alleviates inflammation in knee osteoarthritis.
Wang Y, Ge W, Ma Z, Ji G, Wang M, Zhou G, Wang X
APL bioengineering 2022 Jun;6(2):026101
APL bioengineering 2022 Jun;6(2):026101
Arctiin-reinforced antioxidant microcarrier antagonizes osteoarthritis progression.
Liu Y, Hou M, Pan Z, Tian X, Zhao Z, Liu T, Yang H, Shi Q, Chen X, Zhang Y, He F, Zhu X
Journal of nanobiotechnology 2022 Jun 27;20(1):303
Journal of nanobiotechnology 2022 Jun 27;20(1):303
FABP4 secreted by M1-polarized macrophages promotes synovitis and angiogenesis to exacerbate rheumatoid arthritis.
Guo D, Lin C, Lu Y, Guan H, Qi W, Zhang H, Shao Y, Zeng C, Zhang R, Zhang H, Bai X, Cai D
Bone research 2022 Jun 22;10(1):45
Bone research 2022 Jun 22;10(1):45
Inhibition of HMGB1 suppresses inflammation and catabolism in temporomandibular joint osteoarthritis via NF-κB signaling pathway.
Li YY, Feng YP, Liu L, Ke J, Long X
European journal of histochemistry : EJH 2022 Jun 21;66(3)
European journal of histochemistry : EJH 2022 Jun 21;66(3)
Upregulation of P2Y12 inhibits chondrocyte apoptosis in lumbar osteoarthritis through the PI3K/AKT signaling pathway.
Wu G, Xue P, Jin H, Zhang M, Gui C, Bao G, Xu G, Jiang J, Zhang J, Cui S, Cui Z, Sun Y
Molecular biology reports 2022 Jul;49(7):6459-6466
Molecular biology reports 2022 Jul;49(7):6459-6466
Periostin promotes nucleus pulposus cells apoptosis by activating the Wnt/β-catenin signaling pathway.
Zhu D, Wang Z, Zhang G, Ma C, Qiu X, Wang Y, Liu M, Guo X, Chen H, Deng Q, Kang X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Jul;36(7):e22369
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Jul;36(7):e22369
Asiaticoside ameliorates osteoarthritis progression through activation of Nrf2/HO-1 and inhibition of the NF-κB pathway.
Luo P, Huang Q, Chen S, Wang Y, Dou H
International immunopharmacology 2022 Jul;108:108864
International immunopharmacology 2022 Jul;108:108864
Epigallocatechin-3-O-gallate ameliorates oxidative stress-induced chondrocyte dysfunction and exerts chondroprotective effects via the Keap1/Nrf2/ARE signaling pathway.
Zhu W, Tang H, Cao L, Zhang J, Li J, Ma D, Guo C
Chemical biology & drug design 2022 Jul;100(1):108-120
Chemical biology & drug design 2022 Jul;100(1):108-120
Extracellular vesicles derived from human umbilical cord mesenchymal stem cells alleviate osteoarthritis of the knee in mice model by interacting with METTL3 to reduce m6A of NLRP3 in macrophage.
Zhou H, Shen X, Yan C, Xiong W, Ma Z, Tan Z, Wang J, Li Y, Liu J, Duan A, Liu F
Stem cell research & therapy 2022 Jul 16;13(1):322
Stem cell research & therapy 2022 Jul 16;13(1):322
Histone demethylase JMJD3 downregulation protects against aberrant force-induced osteoarthritis through epigenetic control of NR4A1.
Jin Y, Liu Z, Li Z, Li H, Zhu C, Li R, Zhou T, Fang B
International journal of oral science 2022 Jul 14;14(1):34
International journal of oral science 2022 Jul 14;14(1):34
Mettl3 inhibits the apoptosis and autophagy of chondrocytes in inflammation through mediating Bcl2 stability via Ythdf1-mediated m(6)A modification.
He Y, Wang W, Xu X, Yang B, Yu X, Wu Y, Wang J
Bone 2022 Jan;154:116182
Bone 2022 Jan;154:116182
T-2 toxin induces articular cartilage damage by increasing the expression of MMP-13 via the TGF-β receptor pathway.
Zhang Y, Li Z, He Y, Liu Y, Mi G, Chen J
Human & experimental toxicology 2022 Jan-Dec;41:9603271221075555
Human & experimental toxicology 2022 Jan-Dec;41:9603271221075555
Exosomes derived from platelet-rich plasma administration in site mediate cartilage protection in subtalar osteoarthritis.
Zhang Y, Wang X, Chen J, Qian D, Gao P, Qin T, Jiang T, Yi J, Xu T, Huang Y, Wang Q, Zhou Z, Bao T, Zhao X, Liu H, Zheng Z, Fan J, Zhao S, Li Q, Yin G
Journal of nanobiotechnology 2022 Jan 29;20(1):56
Journal of nanobiotechnology 2022 Jan 29;20(1):56
Mesenchymal stromal cell-derived septoclasts resorb cartilage during developmental ossification and fracture healing.
Sivaraj KK, Majev PG, Jeong HW, Dharmalingam B, Zeuschner D, Schröder S, Bixel MG, Timmen M, Stange R, Adams RH
Nature communications 2022 Jan 28;13(1):571
Nature communications 2022 Jan 28;13(1):571
Anti-inflammatory and immunomodulatory effects of the extracellular vesicles derived from human umbilical cord mesenchymal stem cells on osteoarthritis via M2 macrophages.
Li K, Yan G, Huang H, Zheng M, Ma K, Cui X, Lu D, Zheng L, Zhu B, Cheng J, Zhao J
Journal of nanobiotechnology 2022 Jan 20;20(1):38
Journal of nanobiotechnology 2022 Jan 20;20(1):38
Fermentation supernatant of Staphylococcus aureus drives catabolism in chondrocytes via NF-κB signaling mediated increase of cholesterol metabolism.
Wang Q, Huang J, Li S, Zhang Y, Sun R, Ren J, Shi S, Cui L
Experimental cell research 2022 Jan 1;410(1):112952
Experimental cell research 2022 Jan 1;410(1):112952
SKI knockdown suppresses apoptosis and extracellular matrix degradation of nucleus pulposus cells via inhibition of the Wnt/β-catenin pathway and ameliorates disc degeneration.
Wu ZL, Chen YJ, Zhang GZ, Xie QQ, Wang KP, Yang X, Liu TC, Wang ZQ, Zhao GH, Zhang HH
Apoptosis : an international journal on programmed cell death 2022 Feb;27(1-2):133-148
Apoptosis : an international journal on programmed cell death 2022 Feb;27(1-2):133-148
Transforming growth factor-β receptors mediates matrix degradation and abnormal hypertrophy in T-2 toxin-induced hypertrophic chondrocytes.
Zhang Y, Li Z, He Y, Zhang M, Feng Y, Fang Q, Ma T, Deng X, Chen J
Toxicon : official journal of the International Society on Toxinology 2022 Feb;207:13-20
Toxicon : official journal of the International Society on Toxinology 2022 Feb;207:13-20
Restoring the dampened expression of the core clock molecule BMAL1 protects against compression-induced intervertebral disc degeneration.
Wang D, Peng P, Dudek M, Hu X, Xu X, Shang Q, Wang D, Jia H, Wang H, Gao B, Zheng C, Mao J, Gao C, He X, Cheng P, Wang H, Zheng J, Hoyland JA, Meng QJ, Luo Z, Yang L
Bone research 2022 Feb 25;10(1):20
Bone research 2022 Feb 25;10(1):20
Cartilage Repair Using Clematis Triterpenoid Saponin Delivery Microcarrier, Cultured in a Microgravity Bioreactor Prior to Application in Rabbit Model.
Tu P, Pan Y, Wu C, Yang G, Zhou X, Sun J, Wang L, Liu M, Wang Z, Liang Z, Guo Y, Ma Y
ACS biomaterials science & engineering 2022 Feb 14;8(2):753-764
ACS biomaterials science & engineering 2022 Feb 14;8(2):753-764
dsRNA Induced IFNβ-MMP13 Axis Drives Corneal Wound Healing.
Lan X, Zhang W, Zhu J, Huang H, Mo K, Guo H, Zhu L, Liu J, Li M, Wang L, Liu C, Ji J, Ouyang H
Investigative ophthalmology & visual science 2022 Feb 1;63(2):14
Investigative ophthalmology & visual science 2022 Feb 1;63(2):14
Stabilization of hypoxia-inducible factor-1α alleviates osteoarthritis via interacting with Per2 and resetting the circadian clock.
Wang C, Zhang Y, Wang Z, Yu W, Tong M, Yan Z
Tissue & cell 2022 Dec;79:101942
Tissue & cell 2022 Dec;79:101942
S100A10 regulates tumor necrosis factor alpha-induced apoptosis in chondrocytes via the reactive oxygen species/nuclear factor-kappa B pathway.
Guo Y, Li R, Dang X
Biotechnology and applied biochemistry 2022 Dec;69(6):2284-2295
Biotechnology and applied biochemistry 2022 Dec;69(6):2284-2295
A plant-derived natural photosynthetic system for improving cell anabolism.
Chen P, Liu X, Gu C, Zhong P, Song N, Li M, Dai Z, Fang X, Liu Z, Zhang J, Tang R, Fan S, Lin X
Nature 2022 Dec;612(7940):546-554
Nature 2022 Dec;612(7940):546-554
Shoc2 controls ERK1/2-driven neural crest development by balancing components of the extracellular matrix.
Norcross RG, Abdelmoti L, Rouchka EC, Andreeva K, Tussey O, Landestoy D, Galperin E
Developmental biology 2022 Dec;492:156-171
Developmental biology 2022 Dec;492:156-171
Nodakenin attenuates cartilage degradation and inflammatory responses in a mice model of knee osteoarthritis by regulating mitochondrial Drp1/ROS/NLRP3 axis.
Yi N, Mi Y, Xu X, Li N, Chen B, Yan K, Tan K, Zhang B, Wang L, Kuang G, Lu M
International immunopharmacology 2022 Dec;113(Pt A):109349
International immunopharmacology 2022 Dec;113(Pt A):109349
Traumatic temporomandibular joint bony ankylosis in growing rats.
Ma Z, Wang Y, Xue Y, Zhang W, Li D, Li Y, Li G, Zhou H, Hu X, Deng T, Hu K
BMC oral health 2022 Dec 9;22(1):585
BMC oral health 2022 Dec 9;22(1):585
Osthole Suppresses Knee Osteoarthritis Development by Enhancing Autophagy Activated via the AMPK/ULK1 Pathway.
Ma T, Wang X, Qu W, Yang L, Jing C, Zhu B, Zhang Y, Xie W
Molecules (Basel, Switzerland) 2022 Dec 6;27(23)
Molecules (Basel, Switzerland) 2022 Dec 6;27(23)
Metformin mitigates cholesterol accumulation via the AMPK/SIRT1 pathway to protect osteoarthritis chondrocytes.
Xing H, Liang C, Wang C, Xu X, Hu Y, Qiu B
Biochemical and biophysical research communications 2022 Dec 3;632:113-121
Biochemical and biophysical research communications 2022 Dec 3;632:113-121
An Injectable Hydrogel Scaffold Loaded with Dual-Drug/Sustained-Release PLGA Microspheres for the Regulation of Macrophage Polarization in the Treatment of Intervertebral Disc Degeneration.
Cheng H, Guo Q, Zhao H, Liu K, Kang H, Gao F, Guo J, Yuan X, Hu S, Li F, Yang Q, Fang Z
International journal of molecular sciences 2022 Dec 26;24(1)
International journal of molecular sciences 2022 Dec 26;24(1)
Protective role of Achyranthes bidentata polysaccharides against chondrocyte extracellular matrix degeneration through lncRNA GAS5 in osteoarthritis.
Fu C, Qiu Z, Huang Y, Mei Y, Lin Q, Zeng J, Zhong W, Ma D
Experimental and therapeutic medicine 2022 Aug;24(2):532
Experimental and therapeutic medicine 2022 Aug;24(2):532
Circular RNA circNFKB1 promotes osteoarthritis progression through interacting with ENO1 and sustaining NF-κB signaling.
Tang S, Nie X, Ruan J, Cao Y, Kang J, Ding C
Cell death & disease 2022 Aug 9;13(8):695
Cell death & disease 2022 Aug 9;13(8):695
PCB153 suppressed autophagy via PI3K/Akt/mTOR and RICTOR/Akt/mTOR signaling by the upregulation of microRNA-155 in rat primary chondrocytes.
Liu Z, Huang Y, Jin X, Liu L, Gu H
Toxicology and applied pharmacology 2022 Aug 15;449:116135
Toxicology and applied pharmacology 2022 Aug 15;449:116135
Tri-n-butyl phosphate delays tissue repair by dysregulating neutrophil function in zebrafish.
Wang Y, Cheng Z, Zhang H, Li S, Pan Y, Zhang W, Huang S, He X, Zou F, Yuan Z, Yan W, Huang H
Toxicology and applied pharmacology 2022 Aug 15;449:116114
Toxicology and applied pharmacology 2022 Aug 15;449:116114
TET enzymes regulate skeletal development through increasing chromatin accessibility of RUNX2 target genes.
Wang L, You X, Ruan D, Shao R, Dai HQ, Shen W, Xu GL, Liu W, Zou W
Nature communications 2022 Aug 11;13(1):4709
Nature communications 2022 Aug 11;13(1):4709
Tangeretin suppresses osteoarthritis progression via the Nrf2/NF-κB and MAPK/NF-κB signaling pathways.
Shi Y, Chen J, Li S, Wu Y, Yu C, Ni L, Xiao J, Shao Z, Zhu H, Wang J, Wang X, Zhang X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Apr;98:153928
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Apr;98:153928
Itaconate attenuates osteoarthritis by inhibiting STING/NF-κB axis in chondrocytes and promoting M2 polarization in macrophages.
Ni L, Lin Z, Hu S, Shi Y, Jiang Z, Zhao J, Zhou Y, Wu Y, Tian N, Sun L, Wu A, Pan Z, Zhang X, Wang X
Biochemical pharmacology 2022 Apr;198:114935
Biochemical pharmacology 2022 Apr;198:114935
Ellagic acid attenuates interleukin-1β-induced oxidative stress and exerts protective effects on chondrocytes through the Kelch-like ECH-associated protein 1 (Keap1)/ Nuclear factor erythroid 2-related factor 2 (Nrf2) pathway.
Zhu W, Tang H, Li J, Guedes RM, Cao L, Guo C
Bioengineered 2022 Apr;13(4):9233-9247
Bioengineered 2022 Apr;13(4):9233-9247
Elevation of α-1,3 fucosylation promotes the binding ability of TNFR1 to TNF-α and contributes to osteoarthritic cartilage destruction and apoptosis.
Yu H, Li M, Wen X, Yang J, Liang X, Li X, Bao X, Shu J, Ren X, Chen W, Li Z, Li Y
Arthritis research & therapy 2022 Apr 29;24(1):93
Arthritis research & therapy 2022 Apr 29;24(1):93
Exosomes derived from hypoxia preconditioned mesenchymal stem cells laden in a silk hydrogel promote cartilage regeneration via the miR-205-5p/PTEN/AKT pathway.
Shen K, Duan A, Cheng J, Yuan T, Zhou J, Song H, Chen Z, Wan B, Liu J, Zhang X, Zhang Y, Xie R, Liu F, Fan W, Zuo Q
Acta biomaterialia 2022 Apr 15;143:173-188
Acta biomaterialia 2022 Apr 15;143:173-188
Apigenin Alleviates Intervertebral Disc Degeneration via Restoring Autophagy Flux in Nucleus Pulposus Cells.
Xie C, Shi Y, Chen Z, Zhou X, Luo P, Hong C, Tian N, Wu Y, Zhou Y, Lin Y, Dou H, Wu A, Huang Q, Zhang X, Wang X
Frontiers in cell and developmental biology 2021;9:787278
Frontiers in cell and developmental biology 2021;9:787278
LncRNA Malat-1 From MSCs-Derived Extracellular Vesicles Suppresses Inflammation and Cartilage Degradation in Osteoarthritis.
Pan C, Huang W, Chen Q, Xu J, Yao G, Li B, Wu T, Yin C, Cheng X
Frontiers in bioengineering and biotechnology 2021;9:772002
Frontiers in bioengineering and biotechnology 2021;9:772002
Reducing Inflammation and Vascular Invasion in Intervertebral Disc Degeneration via Cystathionine-γ-Lyase Inhibitory Effect on E-Selectin.
Xu H, Wei K, Tu J, Chen Y, He Y, Ding Y, Xu H, Bao X, Xie H, Fang H, Wang H
Frontiers in cell and developmental biology 2021;9:741046
Frontiers in cell and developmental biology 2021;9:741046
Osteocyte Apoptosis Contributes to Cold Exposure-induced Bone Loss.
Du J, He Z, Cui J, Li H, Xu M, Zhang S, Zhang S, Yan M, Qu X, Yu Z
Frontiers in bioengineering and biotechnology 2021;9:733582
Frontiers in bioengineering and biotechnology 2021;9:733582
Exosomes Isolated From Bone Marrow Mesenchymal Stem Cells Exert a Protective Effect on Osteoarthritis via lncRNA LYRM4-AS1-GRPR-miR-6515-5p.
Wang X, Li Z, Cui Y, Cui X, Chen C, Wang Z
Frontiers in cell and developmental biology 2021;9:644380
Frontiers in cell and developmental biology 2021;9:644380
Single-Cell Profiles of Age-Related Osteoarthritis Uncover Underlying Heterogeneity Associated With Disease Progression.
Liu W, Chen Y, Zeng G, Yang S, Yang T, Ma M, Song W
Frontiers in molecular biosciences 2021;8:748360
Frontiers in molecular biosciences 2021;8:748360
Leptin Induced TLR4 Expression via the JAK2-STAT3 Pathway in Obesity-Related Osteoarthritis.
Jiang M, He J, Sun Y, Dong X, Yao J, Gu H, Liu L
Oxidative medicine and cellular longevity 2021;2021:7385160
Oxidative medicine and cellular longevity 2021;2021:7385160
MCC950, the NLRP3 Inhibitor, Protects against Cartilage Degradation in a Mouse Model of Osteoarthritis.
Ni B, Pei W, Qu Y, Zhang R, Chu X, Wang Y, Huang X, You H
Oxidative medicine and cellular longevity 2021;2021:4139048
Oxidative medicine and cellular longevity 2021;2021:4139048
Bardoxolone-Methyl Prevents Oxidative Stress-Mediated Apoptosis and Extracellular Matrix Degradation in vitro and Alleviates Osteoarthritis in vivo.
Pang Z, Jiang Z, Zhu R, Song C, Tang H, Cao L, Guo C
Drug design, development and therapy 2021;15:3735-3747
Drug design, development and therapy 2021;15:3735-3747
1,25-Dihydroxyvitamin D Inhibits Osteoarthritis by Modulating Interaction Between Vitamin D Receptor and NLRP3 in Macrophages.
Duan A, Ma Z, Liu W, Shen K, Zhou H, Wang S, Kong R, Shao Y, Chen Y, Guo W, Liu F
Journal of inflammation research 2021;14:6523-6542
Journal of inflammation research 2021;14:6523-6542
Aberrant Fluid Shear Stress Contributes to Articular Cartilage Pathogenesis via Epigenetic Regulation of ZBTB20 by H3K4me3.
Jin Y, Li Z, Wu Y, Li H, Liu Z, Liu L, Ouyang N, Zhou T, Fang B, Xia L
Journal of inflammation research 2021;14:6067-6083
Journal of inflammation research 2021;14:6067-6083
Exosome-Encapsulated microRNA-127-3p Released from Bone Marrow-Derived Mesenchymal Stem Cells Alleviates Osteoarthritis Through Regulating CDH11-Mediated Wnt/β-Catenin Pathway.
Dong J, Li L, Fang X, Zang M
Journal of pain research 2021;14:297-310
Journal of pain research 2021;14:297-310
Isovitexin Depresses Osteoarthritis Progression via the Nrf2/NF-κB Pathway: An in vitro Study.
Hu X, Li R, Sun M, Kong Y, Zhu H, Wang F, Wan Q
Journal of inflammation research 2021;14:1403-1414
Journal of inflammation research 2021;14:1403-1414
Physalin A Inhibits MAPK and NF-κB Signal Transduction Through Integrin αVβ3 and Exerts Chondroprotective Effect.
Lu R, Yu X, Liang S, Cheng P, Wang Z, He ZY, Lv ZT, Wan J, Mo H, Zhu WT, Chen AM
Frontiers in pharmacology 2021;12:761922
Frontiers in pharmacology 2021;12:761922
Therapeutic Effects of Naringin in Rheumatoid Arthritis: Network Pharmacology and Experimental Validation.
Aihaiti Y, Song Cai Y, Tuerhong X, Ni Yang Y, Ma Y, Shi Zheng H, Xu K, Xu P
Frontiers in pharmacology 2021;12:672054
Frontiers in pharmacology 2021;12:672054
Exhausting circ_0136474 and Restoring miR-766-3p Attenuate Chondrocyte Oxidative Injury in IL-1β-Induced Osteoarthritis Progression Through Regulating DNMT3A.
Zhu H, Zhu S, Shang X, Meng X, Jing S, Yu L, Deng Y
Frontiers in genetics 2021;12:648709
Frontiers in genetics 2021;12:648709
MicroRNA-497 Reduction and Increase of Its Family Member MicroRNA-424 Lead to Dysregulation of Multiple Inflammation Related Genes in Synovial Fibroblasts With Rheumatoid Arthritis.
Wang S, Xu J, Guo Y, Cai Y, Ren X, Zhu W, Geng M, Meng L, Jiang C, Lu S
Frontiers in immunology 2021;12:619392
Frontiers in immunology 2021;12:619392
Injectable exosome-functionalized extracellular matrix hydrogel for metabolism balance and pyroptosis regulation in intervertebral disc degeneration.
Xing H, Zhang Z, Mao Q, Wang C, Zhou Y, Zhou X, Ying L, Xu H, Hu S, Zhang N
Journal of nanobiotechnology 2021 Sep 6;19(1):264
Journal of nanobiotechnology 2021 Sep 6;19(1):264
Integrative analysis of genome-wide DNA methylation and single-nucleotide polymorphism identified ACSM5 as a suppressor of lumbar ligamentum flavum hypertrophy.
Cao Y, Zhan Y, Qiu S, Chen Z, Gong K, Ni S, Duan Y
Arthritis research & therapy 2021 Sep 30;23(1):251
Arthritis research & therapy 2021 Sep 30;23(1):251
18β-Glycyrrhetinic acid inhibits IL-1β-induced inflammatory response in mouse chondrocytes and prevents osteoarthritic progression by activating Nrf2.
Chen B, Zhu D, Xie C, Shi Y, Ni L, Zhang H, Li S, Lu J, Xiao J, Xia W, Huang C, Wang X
Food & function 2021 Sep 20;12(18):8399-8410
Food & function 2021 Sep 20;12(18):8399-8410
Therapeutic effect of neohesperidin on TNF-α-stimulated human rheumatoid arthritis fibroblast-like synoviocytes.
Wang XH, Dai C, Wang J, Liu R, Li L, Yin ZS
Chinese journal of natural medicines 2021 Oct;19(10):741-749
Chinese journal of natural medicines 2021 Oct;19(10):741-749
Frugoside delays osteoarthritis progression via inhibiting miR-155-modulated synovial macrophage M1 polarization.
Wang H, Zhang H, Fan K, Zhang D, Hu A, Zeng X, Liu YL, Tan G, Wang H
Rheumatology (Oxford, England) 2021 Oct 2;60(10):4899-4909
Rheumatology (Oxford, England) 2021 Oct 2;60(10):4899-4909
SP600125 Restored TNF-α-Induced Impaired Chondrogenesis in Bone Mesenchymal Stem Cells and Its Antiosteoarthritis Effect in Mice.
Ding N, Zeng MY, Song WJ, Xiao CX, Li EM, Wei B
Stem cells and development 2021 Oct 15;30(20):1028-1036
Stem cells and development 2021 Oct 15;30(20):1028-1036
Compressive force regulates cementoblast migration via downregulation of autophagy.
Yang Y, Huang Y, Liu H, Zheng Y, Jia L, Li W
Journal of periodontology 2021 Nov;92(11):128-138
Journal of periodontology 2021 Nov;92(11):128-138
Effects of mechanical stress and deficiency of dihydrotestosterone or 17β-estradiol on Temporomandibular Joint Osteoarthritis in mice.
Ootake T, Ishii T, Sueishi K, Watanabe A, Ishizuka Y, Amano K, Nagao M, Nishimura K, Nishii Y
Osteoarthritis and cartilage 2021 Nov;29(11):1575-1589
Osteoarthritis and cartilage 2021 Nov;29(11):1575-1589
Zonal-Layered Chondrocyte Sheets for Repairment of Full-Thickness Articular Cartilage Defect: A Mini-Pig Model.
Shen PC, Lu CC, Chou SH, Liu ZM, Su SJ, Tien YC
Biomedicines 2021 Nov 30;9(12)
Biomedicines 2021 Nov 30;9(12)
MFG-E8 regulated by miR-99b-5p protects against osteoarthritis by targeting chondrocyte senescence and macrophage reprogramming via the NF-κB pathway.
Lu Y, Liu L, Pan J, Luo B, Zeng H, Shao Y, Zhang H, Guan H, Guo D, Zeng C, Zhang R, Bai X, Zhang H, Cai D
Cell death & disease 2021 May 25;12(6):533
Cell death & disease 2021 May 25;12(6):533
Decreased miR-214-3p activates NF-κB pathway and aggravates osteoarthritis progression.
Cao Y, Tang S, Nie X, Zhou Z, Ruan G, Han W, Zhu Z, Ding C
EBioMedicine 2021 Mar;65:103283
EBioMedicine 2021 Mar;65:103283
Senolytic agent Quercetin ameliorates intervertebral disc degeneration via the Nrf2/NF-κB axis.
Shao Z, Wang B, Shi Y, Xie C, Huang C, Chen B, Zhang H, Zeng G, Liang H, Wu Y, Zhou Y, Tian N, Wu A, Gao W, Wang X, Zhang X
Osteoarthritis and cartilage 2021 Mar;29(3):413-422
Osteoarthritis and cartilage 2021 Mar;29(3):413-422
d-Mannose suppresses osteoarthritis development in vivo and delays IL-1β-induced degeneration in vitro by enhancing autophagy activated via the AMPK pathway.
Lin Z, Miao J, Zhang T, He M, Zhou X, Zhang H, Gao Y, Bai L
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Mar;135:111199
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Mar;135:111199
Cardamonin protects nucleus pulposus cells against IL-1β-induced inflammation and catabolism via Nrf2/NF-κB axis.
Xie C, Ma H, Shi Y, Li J, Wu H, Wang B, Shao Z, Huang C, Chen J, Sun L, Zhou Y, Tian N, Wu Y, Gao W, Wu A, Wang X, Zhang X
Food & function 2021 Mar 21;12(6):2703-2714
Food & function 2021 Mar 21;12(6):2703-2714
Inhibition of HDAC6 by Tubastatin A reduces chondrocyte oxidative stress in chondrocytes and ameliorates mouse osteoarthritis by activating autophagy.
Shen Z, Ji K, Cai Z, Huang C, He X, Xu H, Chen G
Aging 2021 Mar 19;13(7):9820-9837
Aging 2021 Mar 19;13(7):9820-9837
BMP5 silencing inhibits chondrocyte senescence and apoptosis as well as osteoarthritis progression in mice.
Shao Y, Zhao C, Pan J, Zeng C, Zhang H, Liu L, Fan K, Liu X, Luo B, Fang H, Bai X, Zhang H, Cai D
Aging 2021 Mar 19;13(7):9646-9664
Aging 2021 Mar 19;13(7):9646-9664
Staphylococcus aureus on the effect of expression of MMPs/TIMPs and uPA system in bovine mammary fibroblasts.
Miao Z, Ding Y, Bi Y, Chen M, Cao X, Wang F
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 2021 Jun;54(3):411-419
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 2021 Jun;54(3):411-419
Phgdh serves a protective role in Il‑1β induced chondrocyte inflammation and oxidative‑stress damage.
Huang H, Liu K, Ou H, Qian X, Wan J
Molecular medicine reports 2021 Jun;23(6)
Molecular medicine reports 2021 Jun;23(6)
AMD3465 (hexahydrobromide) rescues the MG63 osteoblasts against the apoptosis induced by high glucose.
Zhang Z, Wu H, Huang S, Chen L, Chen X, Zhang W, Liao L, Zhang X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jun;138:111476
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jun;138:111476
Global Deletion of Pannexin 3 Resulting in Accelerated Development of Aging-Induced Osteoarthritis in Mice.
Moon PM, Shao ZY, Wambiekele G, Appleton CTG, Laird DW, Penuela S, Beier F
Arthritis & rheumatology (Hoboken, N.J.) 2021 Jul;73(7):1178-1188
Arthritis & rheumatology (Hoboken, N.J.) 2021 Jul;73(7):1178-1188
TGF-β/Alk5 signaling prevents osteoarthritis initiation via regulating the senescence of articular cartilage stem cells.
Tan Q, Wang Q, Kuang L, Zhang J, Peng X, Liang S, Liu M, Chen H, Chen S, Luo X, Qi H, Li C, Luo F, Huang S, Ni Z, Jin M, Su N, Yang J, Yang P, Chen B, Chen L, Du X, Xie Y, Chen L
Journal of cellular physiology 2021 Jul;236(7):5278-5292
Journal of cellular physiology 2021 Jul;236(7):5278-5292
α-Cyperone (CYP) down-regulates NF-κB and MAPKs signaling, attenuating inflammation and extracellular matrix degradation in chondrocytes, to ameliorate osteoarthritis in mice.
Zhang H, Li S, Lu J, Jin J, Zhu G, Wang L, Yan Y, He L, Wang B, Wang X, Yu H
Aging 2021 Jul 8;13(13):17690-17706
Aging 2021 Jul 8;13(13):17690-17706
Activation of transient receptor potential vanilloid 4 protects articular cartilage against inflammatory responses via CaMKK/AMPK/NF-κB signaling pathway.
Hattori K, Takahashi N, Terabe K, Ohashi Y, Kishimoto K, Yokota Y, Suzuki M, Kojima T, Imagama S
Scientific reports 2021 Jul 30;11(1):15508
Scientific reports 2021 Jul 30;11(1):15508
Metabolic reprogramming in chondrocytes to promote mitochondrial respiration reduces downstream features of osteoarthritis.
Ohashi Y, Takahashi N, Terabe K, Tsuchiya S, Kojima T, Knudson CB, Knudson W, Imagama S
Scientific reports 2021 Jul 23;11(1):15131
Scientific reports 2021 Jul 23;11(1):15131
LncRNA H19-Derived miR-675-5p Accelerates the Invasion of Extravillous Trophoblast Cells by Inhibiting GATA2 and Subsequently Activating Matrix Metalloproteinases.
Ogoyama M, Ohkuchi A, Takahashi H, Zhao D, Matsubara S, Takizawa T
International journal of molecular sciences 2021 Jan 27;22(3)
International journal of molecular sciences 2021 Jan 27;22(3)
The Role of Panx3 in Age-Associated and Injury-Induced Intervertebral Disc Degeneration.
Serjeant M, Moon PM, Quinonez D, Penuela S, Beier F, Séguin CA
International journal of molecular sciences 2021 Jan 22;22(3)
International journal of molecular sciences 2021 Jan 22;22(3)
Endoplasmic reticulum stress pathway mediates T-2 toxin-induced chondrocyte apoptosis.
Liu YN, Mu YD, Wang H, Zhang M, Shi YW, Mi G, Peng LX, Chen JH
Toxicology 2021 Dec;464:152989
Toxicology 2021 Dec;464:152989
Acetabular development and fate of inverted limbus in rabbits: Experimental observation from an animal model.
Liu J, Zhou W, Chen Y, Li L
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2021 Dec;39(12):2595-2603
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2021 Dec;39(12):2595-2603
Glucagon-like peptide-1 receptor activation maintains extracellular matrix integrity by inhibiting the activity of mitogen-activated protein kinases and activator protein-1.
Peng Y, Lin H, Tian S, Liu S, Li J, Lv X, Chen S, Zhao L, Pu F, Chen X, Shu H, Qing X, Shao Z
Free radical biology & medicine 2021 Dec;177:247-259
Free radical biology & medicine 2021 Dec;177:247-259
Silencing BLNK protects against interleukin-1β-induced chondrocyte injury through the NF-κB signaling pathway.
Cheng Y, Li F, Zhang WS, Zou GY, Shen YX
Cytokine 2021 Dec;148:155686
Cytokine 2021 Dec;148:155686
Physiological Reloading Recovers Histologically Disuse Atrophy of the Articular Cartilage and Bone by Hindlimb Suspension in Rat Knee Joint.
Takahashi I, Matsuzaki T, Kuroki H, Hoso M
Cartilage 2021 Dec;13(2_suppl):1530S-1539S
Cartilage 2021 Dec;13(2_suppl):1530S-1539S
MicroRNA-4423-3p inhibits proliferation of fibroblast-like synoviocytes by targeting matrix metalloproteinase 13 in rheumatoid arthritis.
Xu W, Ye L, Wu H
Bioengineered 2021 Dec;12(2):9411-9423
Bioengineered 2021 Dec;12(2):9411-9423
Role of the hippo signaling pathway in the extracellular matrix degradation of chondrocytes induced by fluoride exposure.
Yu FF, Zuo J, Fu X, Gao MH, Sun L, Yu SY, Li Z, Zhou GY, Ba Y
Ecotoxicology and environmental safety 2021 Dec 1;225:112796
Ecotoxicology and environmental safety 2021 Dec 1;225:112796
TGF-β1-stimulation of NFATC2 and ATF3 proteins and their interaction for matrix metalloproteinase 13 expression in human breast cancer cells.
Rohini M, Vairamani M, Selvamurugan N
International journal of biological macromolecules 2021 Dec 1;192:1325-1330
International journal of biological macromolecules 2021 Dec 1;192:1325-1330
Involvement of Transient Receptor Potential Vanilloid Channel 2 in the Induction of Lubricin and Suppression of Ectopic Endochondral Ossification in Mouse Articular Cartilage.
Nakamoto H, Katanosaka Y, Chijimatsu R, Mori D, Xuan F, Yano F, Omata Y, Maenohara Y, Murahashi Y, Kawaguchi K, Yamagami R, Inui H, Taketomi S, Taniguchi Y, Kanagawa M, Naruse K, Tanaka S, Saito T
Arthritis & rheumatology (Hoboken, N.J.) 2021 Aug;73(8):1441-1450
Arthritis & rheumatology (Hoboken, N.J.) 2021 Aug;73(8):1441-1450
Scleraxis expressing scleral cells respond to inflammatory stimulation.
Atta G, Schroedl F, Kaser-Eichberger A, Spitzer G, Traweger A, Heindl LM, Tempfer H
Histochemistry and cell biology 2021 Aug;156(2):123-132
Histochemistry and cell biology 2021 Aug;156(2):123-132
Suramin attenuates intervertebral disc degeneration by inhibiting NF-κB signalling pathway.
Liu ZM, Lu CC, Shen PC, Chou SH, Shih CL, Chen JC, Tien YC
Bone & joint research 2021 Aug;10(8):498-513
Bone & joint research 2021 Aug;10(8):498-513
METTL3 involves the progression of osteoarthritis probably by affecting ECM degradation and regulating the inflammatory response.
Sang W, Xue S, Jiang Y, Lu H, Zhu L, Wang C, Ma J
Life sciences 2021 Aug 1;278:119528
Life sciences 2021 Aug 1;278:119528
Oroxylin A attenuates IL-1β-induced inflammatory reaction via inhibiting the activation of the ERK and PI3K/AKT signaling pathways in osteoarthritis chondrocytes.
Zhang Y, Weng Q, Chen J, Li M, Han J
Experimental and therapeutic medicine 2021 Apr;21(4):388
Experimental and therapeutic medicine 2021 Apr;21(4):388
Effects of HDAC4 on IL-1β-induced matrix metalloproteinase expression regulated partially through the WNT3A/β-catenin pathway.
Ning Q, Gan YH, Shi RR, Meng JH
Chinese medical journal 2021 Apr 8;134(8):963-970
Chinese medical journal 2021 Apr 8;134(8):963-970
ZIP8 mediates the extracellular matrix degradation of nucleus pulposus cells via NF-κB signaling pathway.
Ding W, Ge Y, Sun H, Xu J, Gu H, Bian C, Chen H, Jiang L, Yin X
Biochemical and biophysical research communications 2021 Apr 23;550:30-36
Biochemical and biophysical research communications 2021 Apr 23;550:30-36
OPN Deficiency Increases the Severity of Osteoarthritis Associated with Aberrant Chondrocyte Senescence and Apoptosis and Upregulates the Expression of Osteoarthritis-Associated Genes.
Tian J, Cheng C, Kuang SD, Su C, Zhao X, Xiong YL, Li YS, Gao SG
Pain research & management 2020;2020:3428587
Pain research & management 2020;2020:3428587
Punicalagin Inhibits Tert-Butyl Hydroperoxide-Induced Apoptosis and Extracellular Matrix Degradation in Chondrocytes by Activating Autophagy and Ameliorates Murine Osteoarthritis.
Kong J, Wang J, Gong X, Zheng X, Chen T
Drug design, development and therapy 2020;14:5521-5533
Drug design, development and therapy 2020;14:5521-5533
LncRNA TRPC7-AS1 regulates nucleus pulposus cellular senescence and ECM synthesis via competing with HPN for miR-4769-5p binding.
Wang X, Li D, Wu H, Liu F, Liu F, Zhang Q, Li J
Mechanisms of ageing and development 2020 Sep;190:111293
Mechanisms of ageing and development 2020 Sep;190:111293
A chondroprotective effect of moracin on IL-1β-induced primary rat chondrocytes and an osteoarthritis rat model through Nrf2/HO-1 and NF-κB axes.
Zhou S, Shi J, Wen H, Xie W, Han X, Li H
Food & function 2020 Sep 23;11(9):7935-7945
Food & function 2020 Sep 23;11(9):7935-7945
TLR4 contributes to the damage of cartilage and subchondral bone in discectomy-induced TMJOA mice.
Liu X, Cai HX, Cao PY, Feng Y, Jiang HH, Liu L, Ke J, Long X
Journal of cellular and molecular medicine 2020 Oct;24(19):11489-11499
Journal of cellular and molecular medicine 2020 Oct;24(19):11489-11499
S-allyl cysteine reduces osteoarthritis pathology in the tert-butyl hydroperoxide-treated chondrocytes and the destabilization of the medial meniscus model mice via the Nrf2 signaling pathway.
Shao Z, Pan Z, Lin J, Zhao Q, Wang Y, Ni L, Feng S, Tian N, Wu Y, Sun L, Gao W, Zhou Y, Zhang X, Wang X
Aging 2020 Oct 7;12(19):19254-19272
Aging 2020 Oct 7;12(19):19254-19272
IL-37 inhibits M1-like macrophage activation to ameliorate temporomandibular joint inflammation through the NLRP3 pathway.
Luo P, Peng S, Yan Y, Ji P, Xu J
Rheumatology (Oxford, England) 2020 Oct 1;59(10):3070-3080
Rheumatology (Oxford, England) 2020 Oct 1;59(10):3070-3080
Heparan sulfate deficiency leads to hypertrophic chondrocytes by increasing bone morphogenetic protein signaling.
Kawashima K, Ogawa H, Komura S, Ishihara T, Yamaguchi Y, Akiyama H, Matsumoto K
Osteoarthritis and cartilage 2020 Nov;28(11):1459-1470
Osteoarthritis and cartilage 2020 Nov;28(11):1459-1470
miR-873-3p targets HDAC4 to stimulate matrix metalloproteinase-13 expression upon parathyroid hormone exposure in rat osteoblasts.
Malavika D, Shreya S, Raj Priya V, Rohini M, He Z, Partridge NC, Selvamurugan N
Journal of cellular physiology 2020 Nov;235(11):7996-8009
Journal of cellular physiology 2020 Nov;235(11):7996-8009
Overexpression of MIG-6 in the cartilage induces an osteoarthritis-like phenotype in mice.
Bellini M, Pest MA, Miranda-Rodrigues M, Qin L, Jeong JW, Beier F
Arthritis research & therapy 2020 May 19;22(1):119
Arthritis research & therapy 2020 May 19;22(1):119
Reducing macrophage numbers alleviates temporomandibular joint ankylosis.
Zhao L, Xiao E, He L, Duan D, He Y, Chen S, Zhang Y, Gan Y
Cell and tissue research 2020 Mar;379(3):521-536
Cell and tissue research 2020 Mar;379(3):521-536
Oxymatrine suppresses IL-1β-induced degradation of the nucleus pulposus cell and extracellular matrix through the TLR4/NF-κB signaling pathway.
Wei K, Dai J, Wang Z, Pei Y, Chen Y, Ding Y, Ding Q, Ahati P, Zhou X, Wang H, Fang H
Experimental biology and medicine (Maywood, N.J.) 2020 Mar;245(6):532-541
Experimental biology and medicine (Maywood, N.J.) 2020 Mar;245(6):532-541
Paclitaxel-induced peripheral neuropathy is caused by epidermal ROS and mitochondrial damage through conserved MMP-13 activation.
Cirrincione AM, Pellegrini AD, Dominy JR, Benjamin ME, Utkina-Sosunova I, Lotti F, Jergova S, Sagen J, Rieger S
Scientific reports 2020 Mar 4;10(1):3970
Scientific reports 2020 Mar 4;10(1):3970
Long non-coding RNA SNHG15 is a competing endogenous RNA of miR-141-3p that prevents osteoarthritis progression by upregulating BCL2L13 expression.
Zhang X, Huang CR, Pan S, Pang Y, Chen YS, Zha GC, Guo KJ, Zheng X
International immunopharmacology 2020 Jun;83:106425
International immunopharmacology 2020 Jun;83:106425
Casticin Attenuates Osteoarthritis-Related Cartilage Degeneration by Inhibiting the ROS-Mediated NF-κB Signaling Pathway in vitro and in vivo.
Chu J, Yan B, Zhang J, Peng L, Ao X, Zheng Z, Jiang T, Zhang Z
Inflammation 2020 Jun;43(3):810-820
Inflammation 2020 Jun;43(3):810-820
Curcumol may reverse early and advanced liver fibrogenesis through downregulating the uPA/uPAR pathway.
Li G, Lin J, Peng Y, Qin K, Wen L, Zhao T, Feng Q
Phytotherapy research : PTR 2020 Jun;34(6):1421-1435
Phytotherapy research : PTR 2020 Jun;34(6):1421-1435
MicroRNA-675-3p regulates IL-1β-stimulated human chondrocyte apoptosis and cartilage degradation by targeting GNG5.
Shen XF, Cheng Y, Dong QR, Zheng MQ
Biochemical and biophysical research communications 2020 Jun 25;527(2):458-465
Biochemical and biophysical research communications 2020 Jun 25;527(2):458-465
The protective effect of myricitrin in osteoarthritis: An in vitro and in vivo study.
Yan Z, Lin Z, Wu Y, Zhan J, Qi W, Lin J, Shen J, Xue X, Pan X
International immunopharmacology 2020 Jul;84:106511
International immunopharmacology 2020 Jul;84:106511
MiR-455-3p reduces apoptosis and alleviates degeneration of chondrocyte through regulating PI3K/AKT pathway.
Wen X, Li H, Sun H, Zeng A, Lin R, Zhao J, Zhang Z
Life sciences 2020 Jul 15;253:117718
Life sciences 2020 Jul 15;253:117718
Hypoxic mast cells accelerate the proliferation, collagen accumulation and phenotypic alteration of human lung fibroblasts.
Wang X, Lin L, Chai X, Wu Y, Li Y, Liu X
International journal of molecular medicine 2020 Jan;45(1):175-185
International journal of molecular medicine 2020 Jan;45(1):175-185
Targeting exosome-associated human antigen R attenuates fibrosis and inflammation in diabetic heart.
Govindappa PK, Patil M, Garikipati VNS, Verma SK, Saheera S, Narasimhan G, Zhu W, Kishore R, Zhang J, Krishnamurthy P
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Feb;34(2):2238-2251
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Feb;34(2):2238-2251
MicroRNA-377-3p alleviates IL-1β-caused chondrocyte apoptosis and cartilage degradation in osteoarthritis in part by downregulating ITGA6.
Tu Y, Ma T, Wen T, Yang T, Xue L, Cai M, Wang F, Guan M, Xue H
Biochemical and biophysical research communications 2020 Feb 26;523(1):46-53
Biochemical and biophysical research communications 2020 Feb 26;523(1):46-53
Protective effect of resveratrol on obesity-related osteoarthritis via alleviating JAK2/STAT3 signaling pathway is independent of SOCS3.
Jiang M, He J, Gu H, Yang Y, Huang Y, Xu X, Liu L
Toxicology and applied pharmacology 2020 Feb 1;388:114871
Toxicology and applied pharmacology 2020 Feb 1;388:114871
Inhibition of PI3K/Akt/NF-κB signaling by Aloin for ameliorating the progression of osteoarthritis: In vitro and in vivo studies.
Zhang C, Shao Z, Hu X, Chen Z, Li B, Jiang R, Bsoul N, Chen J, Xu C, Gao W
International immunopharmacology 2020 Dec;89(Pt B):107079
International immunopharmacology 2020 Dec;89(Pt B):107079
Exogenous hydrogen sulfide inhibits apoptosis by regulating endoplasmic reticulum stress-autophagy axis and improves myocardial reconstruction after acute myocardial infarction.
Li Y, Liu M, Yi J, Song X, Zheng X, Liu D, Wang S, Chu C, Yang J
Acta biochimica et biophysica Sinica 2020 Dec 29;52(12):1325-1336
Acta biochimica et biophysica Sinica 2020 Dec 29;52(12):1325-1336
Stachydrine ameliorates the progression of intervertebral disc degeneration via the PI3K/Akt/NF-κB signaling pathway: in vitro and in vivo studies.
Shao Z, Lu J, Zhang C, Zeng G, Chen B, Liang H, Wu A, Zhang X, Wang X
Food & function 2020 Dec 1;11(12):10864-10875
Food & function 2020 Dec 1;11(12):10864-10875
Glycitin Suppresses Cartilage Destruction of Osteoarthritis in Mice.
Wang W, Yang R, Zhang M, Li J, Peng J, Xu M, Zhao Y, Li H, Pan X
Inflammation 2020 Aug;43(4):1312-1322
Inflammation 2020 Aug;43(4):1312-1322
Crenigacestat, a selective NOTCH1 inhibitor, reduces intrahepatic cholangiocarcinoma progression by blocking VEGFA/DLL4/MMP13 axis.
Mancarella S, Serino G, Dituri F, Cigliano A, Ribback S, Wang J, Chen X, Calvisi DF, Giannelli G
Cell death and differentiation 2020 Aug;27(8):2330-2343
Cell death and differentiation 2020 Aug;27(8):2330-2343
Macromechanics and polycaprolactone fiber organization drive macrophage polarization and regulate inflammatory activation of tendon in vitro and in vivo.
Schoenenberger AD, Tempfer H, Lehner C, Egloff J, Mauracher M, Bird A, Widmer J, Maniura-Weber K, Fucentese SF, Traweger A, Silvan U, Snedeker JG
Biomaterials 2020 Aug;249:120034
Biomaterials 2020 Aug;249:120034
Vitamin D3 protects articular cartilage by inhibiting the Wnt/β-catenin signaling pathway.
Yang T, Sun W, Duan YH, Sun YB, Ren YM, Hou WY, Tian MQ
Experimental and therapeutic medicine 2020 Aug;20(2):1775-1781
Experimental and therapeutic medicine 2020 Aug;20(2):1775-1781
IκB kinase α: an independent prognostic factor that promotes the migration and invasion of oral squamous cell carcinoma.
Lv S, Wang F, Wang K, Fan Y, Xu J, Zheng J, Zeng Y
The British journal of oral & maxillofacial surgery 2020 Apr;58(3):296-303
The British journal of oral & maxillofacial surgery 2020 Apr;58(3):296-303
Keratocytes promote corneal neovascularization through VEGFr3 induced by PPARα-inhibition.
Wang X, Tang L, Zhang Z, Li W, Chen Y
Experimental eye research 2020 Apr;193:107982
Experimental eye research 2020 Apr;193:107982
FTO promotes cell proliferation and migration in esophageal squamous cell carcinoma through up-regulation of MMP13.
Liu S, Huang M, Chen Z, Chen J, Chao Q, Yin X, Quan M
Experimental cell research 2020 Apr 1;389(1):111894
Experimental cell research 2020 Apr 1;389(1):111894
25-HC promotes hepatocellular carcinoma metastasis through up-regulation of TLR4 dependent FABP4.
Wang S, Yao Y, Wang X, Zheng G, Ouyang W, Chen W
American journal of cancer research 2019;9(10):2140-2155
American journal of cancer research 2019;9(10):2140-2155
A Compound of Chinese Herbs Protects against Alcoholic Liver Fibrosis in Rats via the TGF-β1/Smad Signaling Pathway.
Li X, Liu Y, Yue W, Tan Y, Wang H, Zhang L, Chen J
Evidence-based complementary and alternative medicine : eCAM 2019;2019:9121347
Evidence-based complementary and alternative medicine : eCAM 2019;2019:9121347
KLF2 Protects against Osteoarthritis by Repressing Oxidative Response through Activation of Nrf2/ARE Signaling In Vitro and In Vivo.
Gao X, Jiang S, Du Z, Ke A, Liang Q, Li X
Oxidative medicine and cellular longevity 2019;2019:8564681
Oxidative medicine and cellular longevity 2019;2019:8564681
Nobiletin Inhibits IL-1β-Induced Inflammation in Chondrocytes via Suppression of NF-κB Signaling and Attenuates Osteoarthritis in Mice.
Lin Z, Wu D, Huang L, Jiang C, Pan T, Kang X, Pan J
Frontiers in pharmacology 2019;10:570
Frontiers in pharmacology 2019;10:570
Targeting the IL-1β/IL-1Ra pathways for the aggregation of human islet amyloid polypeptide in an ex vivo organ culture system of the intervertebral disc.
Wu X, Liao Z, Wang K, Hua W, Liu X, Song Y, Zhang Y, Yang S, Yang C
Experimental & molecular medicine 2019 Sep 25;51(9):1-16
Experimental & molecular medicine 2019 Sep 25;51(9):1-16
Effects of simvastatin on matrix metalloproteinase regulation in IL-1β-induced SW1353 cells.
Cecen B, Keles D, Oktay G, Kozaci LD
Chemico-biological interactions 2019 Sep 1;310:108730
Chemico-biological interactions 2019 Sep 1;310:108730
Alleviation of murine osteoarthritis by deletion of the focal adhesion mechanosensitive adapter, Hic-5.
Miyauchi A, Kim-Kaneyama JR, Lei XF, Chang SH, Saito T, Haraguchi S, Miyazaki T, Miyazaki A
Scientific reports 2019 Oct 31;9(1):15770
Scientific reports 2019 Oct 31;9(1):15770
Development of a Mouse Model of Knee Osteoarthritis Based on Obesity and Bipedal Walking.
Son KM, Jung HA, Hong JI, Park IY, Kim HA
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2019 Nov;37(11):2411-2419
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2019 Nov;37(11):2411-2419
ZnO nanoparticles inhibit the activity of Porphyromonas gingivalis and Actinomyces naeslundii and promote the mineralization of the cementum.
Wang J, Du L, Fu Y, Jiang P, Wang X
BMC oral health 2019 May 14;19(1):84
BMC oral health 2019 May 14;19(1):84
25-HC decreases the sensitivity of human gastric cancer cells to 5-fluorouracil and promotes cells invasion via the TLR2/NF-κB signaling pathway.
Wang S, Yao Y, Rao C, Zheng G, Chen W
International journal of oncology 2019 Mar;54(3):966-980
International journal of oncology 2019 Mar;54(3):966-980
Cortistatin binds to TNF-α receptors and protects against osteoarthritis.
Zhao Y, Li Y, Qu R, Chen X, Wang W, Qiu C, Liu B, Pan X, Liu L, Vasilev K, Hayball J, Dong S, Li W
EBioMedicine 2019 Mar;41:556-570
EBioMedicine 2019 Mar;41:556-570
miR-100-5p-abundant exosomes derived from infrapatellar fat pad MSCs protect articular cartilage and ameliorate gait abnormalities via inhibition of mTOR in osteoarthritis.
Wu J, Kuang L, Chen C, Yang J, Zeng WN, Li T, Chen H, Huang S, Fu Z, Li J, Liu R, Ni Z, Chen L, Yang L
Biomaterials 2019 Jun;206:87-100
Biomaterials 2019 Jun;206:87-100
miR-93-5p attenuates IL-1β-induced chondrocyte apoptosis and cartilage degradation in osteoarthritis partially by targeting TCF4.
Xue H, Tu Y, Ma T, Wen T, Yang T, Xue L, Cai M, Wang F, Guan M
Bone 2019 Jun;123:129-136
Bone 2019 Jun;123:129-136
Adamts17 is involved in skeletogenesis through modulation of BMP-Smad1/5/8 pathway.
Oichi T, Taniguchi Y, Soma K, Oshima Y, Yano F, Mori Y, Chijimatsu R, Kim-Kaneyama JR, Tanaka S, Saito T
Cellular and molecular life sciences : CMLS 2019 Dec;76(23):4795-4809
Cellular and molecular life sciences : CMLS 2019 Dec;76(23):4795-4809
Quercetin alleviates rat osteoarthritis by inhibiting inflammation and apoptosis of chondrocytes, modulating synovial macrophages polarization to M2 macrophages.
Hu Y, Gui Z, Zhou Y, Xia L, Lin K, Xu Y
Free radical biology & medicine 2019 Dec;145:146-160
Free radical biology & medicine 2019 Dec;145:146-160
Reduced PDGF-AA in subchondral bone leads to articular cartilage degeneration after strenuous running.
Yao Z, Chen P, Wang S, Deng G, Hu Y, Lin Q, Zhang X, Yu B
Journal of cellular physiology 2019 Aug;234(10):17946-17958
Journal of cellular physiology 2019 Aug;234(10):17946-17958
Inhibition of Ihh Reverses Temporomandibular Joint Osteoarthritis via a PTH1R Signaling Dependent Mechanism.
Yang H, Zhang M, Liu Q, Zhang H, Zhang J, Lu L, Xie M, Chen D, Wang M
International journal of molecular sciences 2019 Aug 3;20(15)
International journal of molecular sciences 2019 Aug 3;20(15)
Effects of IL-1β on MMP-9 Expression in Cementoblast-Derived Cell Line and MMP-Mediated Degradation of Type I Collagen.
Du M, Wang Y, Liu Z, Wang L, Cao Z, Zhang C, Hao Y, He H
Inflammation 2019 Apr;42(2):413-425
Inflammation 2019 Apr;42(2):413-425
SIRT3 Activation by Dihydromyricetin Suppresses Chondrocytes Degeneration via Maintaining Mitochondrial Homeostasis.
Wang J, Wang K, Huang C, Lin D, Zhou Y, Wu Y, Tian N, Fan P, Pan X, Xu D, Hu J, Zhou Y, Wang X, Zhang X
International journal of biological sciences 2018;14(13):1873-1882
International journal of biological sciences 2018;14(13):1873-1882
mTOR-mediated inactivation of 4E-BP1, an inhibitor of translation, precedes cartilage degeneration in rat osteoarthritic knees.
Katsara O, Kolupaeva V
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2018 Oct;36(10):2728-2735
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2018 Oct;36(10):2728-2735
Differential effects of high-physiological oestrogen on the degeneration of mandibular condylar cartilage and subchondral bone.
Ye T, Sun D, Mu T, Chu Y, Miao H, Zhang M, Yang H, Liu Q, Lu L, Xing X, Yu S
Bone 2018 Jun;111:9-22
Bone 2018 Jun;111:9-22
Loss of Fgfr1 in chondrocytes inhibits osteoarthritis by promoting autophagic activity in temporomandibular joint.
Wang Z, Huang J, Zhou S, Luo F, Tan Q, Sun X, Ni Z, Chen H, Du X, Xie Y, Chen L
The Journal of biological chemistry 2018 Jun 8;293(23):8761-8774
The Journal of biological chemistry 2018 Jun 8;293(23):8761-8774
ETV4 transcription factor and MMP13 metalloprotease are interplaying actors of breast tumorigenesis.
Dumortier M, Ladam F, Damour I, Vacher S, Bièche I, Marchand N, de Launoit Y, Tulasne D, Chotteau-Lelièvre A
Breast cancer research : BCR 2018 Jul 11;20(1):73
Breast cancer research : BCR 2018 Jul 11;20(1):73
Postnatal deletion of Alk5 gene in meniscal cartilage accelerates age-dependent meniscal degeneration in mice.
Wang Q, Tan Q, Xu W, Kuang L, Zhang B, Wang Z, Ni Z, Su N, Jin M, Li C, Jiang W, Huang J, Li F, Zhu Y, Chen H, Du X, Chen D, Deng C, Qi H, Xie Y, Chen L
Journal of cellular physiology 2018 Jan;234(1):595-605
Journal of cellular physiology 2018 Jan;234(1):595-605
Stromal cell‑derived factor‑1 induces matrix metalloproteinase expression in human endplate chondrocytes, cartilage endplate degradation in explant culture, and the amelioration of nucleus pulposus degeneration in vivo.
Zhang H, Zhu T, Zhang L, Wu Q
International journal of molecular medicine 2018 Feb;41(2):969-976
International journal of molecular medicine 2018 Feb;41(2):969-976
Toxoplasma gondii GRA15(II) effector-induced M1 cells ameliorate liver fibrosis in mice infected with Schistosomiasis japonica.
Xie Y, Wen H, Yan K, Wang S, Wang X, Chen J, Li Y, Xu Y, Zhong Z, Shen J, Chu D
Cellular & molecular immunology 2018 Feb;15(2):120-134
Cellular & molecular immunology 2018 Feb;15(2):120-134
Emodin ameliorates cartilage degradation in osteoarthritis by inhibiting NF-κB and Wnt/β-catenin signaling in-vitro and in-vivo.
Ding QH, Ye CY, Chen EM, Zhang W, Wang XH
International immunopharmacology 2018 Aug;61:222-230
International immunopharmacology 2018 Aug;61:222-230
Tumor-derived exosomes educate dendritic cells to promote tumor metastasis via HSP72/HSP105-TLR2/TLR4 pathway.
Shen Y, Guo D, Weng L, Wang S, Ma Z, Yang Y, Wang P, Wang J, Cai Z
Oncoimmunology 2017;6(12):e1362527
Oncoimmunology 2017;6(12):e1362527
Chondroprotective Effects and Multitarget Mechanisms of Fu Yuan Capsule in a Rat Osteoarthritis Model.
Zeng L, Xiao CZ, Deng ZT, Li RH
Evidence-based complementary and alternative medicine : eCAM 2017;2017:8985623
Evidence-based complementary and alternative medicine : eCAM 2017;2017:8985623
Upregulation of FBXW7 Suppresses Renal Cancer Metastasis and Epithelial Mesenchymal Transition.
Cai Y, Zhang M, Qiu X, Wang B, Fu Y, Zeng J, Bai J, Yang G
Disease markers 2017;2017:8276939
Disease markers 2017;2017:8276939
Cartilage-specific deletion of Alk5 gene results in a progressive osteoarthritis-like phenotype in mice.
Wang Q, Tan QY, Xu W, Qi HB, Chen D, Zhou S, Ni ZH, Kuang L, Guo JY, Huang JL, Wang XX, Wang ZQ, Su N, Chen L, Chen B, Jiang WL, Gao Y, Chen HG, Du XL, Xie YL, Chen L
Osteoarthritis and cartilage 2017 Nov;25(11):1868-1879
Osteoarthritis and cartilage 2017 Nov;25(11):1868-1879
Icariin inhibits MMP‑1, MMP‑3 and MMP‑13 expression through MAPK pathways in IL‑1β‑stimulated SW1353 chondrosarcoma cells.
Zeng L, Rong XF, Li RH, Wu XY
Molecular medicine reports 2017 May;15(5):2853-2858
Molecular medicine reports 2017 May;15(5):2853-2858
Simvastatin Inhibits IL-1β-Induced Apoptosis and Extracellular Matrix Degradation by Suppressing the NF-kB and MAPK Pathways in Nucleus Pulposus Cells.
Tu J, Li W, Zhang Y, Wu X, Song Y, Kang L, Liu W, Wang K, Li S, Hua W, Yang C
Inflammation 2017 Jun;40(3):725-734
Inflammation 2017 Jun;40(3):725-734
Potential Involvement of the IL-6/JAK/STAT3 Pathway in the Pathogenesis of Intervertebral Disc Degeneration.
Suzuki S, Fujita N, Fujii T, Watanabe K, Yagi M, Tsuji T, Ishii K, Miyamoto T, Horiuchi K, Nakamura M, Matsumoto M
Spine 2017 Jul 15;42(14):E817-E824
Spine 2017 Jul 15;42(14):E817-E824
AMPK deficiency in chondrocytes accelerated the progression of instability-induced and ageing-associated osteoarthritis in adult mice.
Zhou S, Lu W, Chen L, Ge Q, Chen D, Xu Z, Shi D, Dai J, Li J, Ju H, Cao Y, Qin J, Chen S, Teng H, Jiang Q
Scientific reports 2017 Feb 22;7:43245
Scientific reports 2017 Feb 22;7:43245
Chlorogenic acid prevents inflammatory responses in IL‑1β‑stimulated human SW‑1353 chondrocytes, a model for osteoarthritis.
Liu CC, Zhang Y, Dai BL, Ma YJ, Zhang Q, Wang Y, Yang H
Molecular medicine reports 2017 Aug;16(2):1369-1375
Molecular medicine reports 2017 Aug;16(2):1369-1375
Conditional knockdown of hyaluronidase 2 in articular cartilage stimulates osteoarthritic progression in a mice model.
Higuchi Y, Nishida Y, Kozawa E, Zhuo L, Arai E, Hamada S, Morita D, Ikuta K, Kimata K, Ushida T, Ishiguro N
Scientific reports 2017 Aug 1;7(1):7028
Scientific reports 2017 Aug 1;7(1):7028
Fibroblast Growth Factor Receptor 3 Inhibits Osteoarthritis Progression in the Knee Joints of Adult Mice.
Tang J, Su N, Zhou S, Xie Y, Huang J, Wen X, Wang Z, Wang Q, Xu W, Du X, Chen H, Chen L
Arthritis & rheumatology (Hoboken, N.J.) 2016 Oct;68(10):2432-43
Arthritis & rheumatology (Hoboken, N.J.) 2016 Oct;68(10):2432-43
Iron overload in a murine model of hereditary hemochromatosis is associated with accelerated progression of osteoarthritis under mechanical stress.
Camacho A, Simão M, Ea HK, Cohen-Solal M, Richette P, Branco J, Cancela ML
Osteoarthritis and cartilage 2016 Mar;24(3):494-502
Osteoarthritis and cartilage 2016 Mar;24(3):494-502
Conditional knockout of tissue factor pathway inhibitor 2 in vascular endothelial cells accelerates atherosclerotic plaque development in mice.
Hong J, Liu R, Chen L, Wu B, Yu J, Gao W, Pan J, Luo X, Shi H
Thrombosis research 2016 Jan;137:148-156
Thrombosis research 2016 Jan;137:148-156
Exogenous fibroblast growth factor 9 attenuates cartilage degradation and aggravates osteophyte formation in post-traumatic osteoarthritis.
Zhou S, Wang Z, Tang J, Li W, Huang J, Xu W, Luo F, Xu M, Wang J, Wen X, Chen L, Chen H, Su N, Shen Y, Du X, Xie Y, Chen L
Osteoarthritis and cartilage 2016 Dec;24(12):2181-2192
Osteoarthritis and cartilage 2016 Dec;24(12):2181-2192
Conditional Deletion of Fgfr3 in Chondrocytes leads to Osteoarthritis-like Defects in Temporomandibular Joint of Adult Mice.
Zhou S, Xie Y, Li W, Huang J, Wang Z, Tang J, Xu W, Sun X, Tan Q, Huang S, Luo F, Xu M, Wang J, Wu T, Chen L, Chen H, Su N, Du X, Shen Y, Chen L
Scientific reports 2016 Apr 4;6:24039
Scientific reports 2016 Apr 4;6:24039
Levofloxacin increases apoptosis of rat annulus fibrosus cells via the mechanism of upregulating MMP-2 and MMP-13.
Wei HK, Yang SD, Bai ZL, Zhang X, Yang DL, Ding WY
International journal of clinical and experimental medicine 2015;8(11):20198-207
International journal of clinical and experimental medicine 2015;8(11):20198-207
Deletion of Dual Specificity Phosphatase 1 Does Not Predispose Mice to Increased Spontaneous Osteoarthritis.
Pest MA, Pest CA, Bellini MR, Feng Q, Beier F
PloS one 2015;10(11):e0142822
PloS one 2015;10(11):e0142822
17β-estradiol protects against apoptosis induced by interleukin-1β in rat nucleus pulposus cells by down-regulating MMP-3 and MMP-13.
Yang SD, Yang DL, Sun YP, Wang BL, Ma L, Feng SQ, Ding WY
Apoptosis : an international journal on programmed cell death 2015 Mar;20(3):348-57
Apoptosis : an international journal on programmed cell death 2015 Mar;20(3):348-57
Deletion of Panx3 Prevents the Development of Surgically Induced Osteoarthritis.
Moon PM, Penuela S, Barr K, Khan S, Pin CL, Welch I, Attur M, Abramson SB, Laird DW, Beier F
Journal of molecular medicine (Berlin, Germany) 2015 Aug;93(8):845-56
Journal of molecular medicine (Berlin, Germany) 2015 Aug;93(8):845-56
Potent effects of dioscin against liver fibrosis.
Zhang X, Han X, Yin L, Xu L, Qi Y, Xu Y, Sun H, Lin Y, Liu K, Peng J
Scientific reports 2015 Apr 8;5:9713
Scientific reports 2015 Apr 8;5:9713
Keratocytes create stromal spaces to promote corneal neovascularization via MMP13 expression.
Ma J, Zhou D, Fan M, Wang H, Huang C, Zhang Z, Wu Y, Li W, Chen Y, Liu Z
Investigative ophthalmology & visual science 2014 Sep 4;55(10):6691-703
Investigative ophthalmology & visual science 2014 Sep 4;55(10):6691-703
Protective effects of biochanin A on articular cartilage: in vitro and in vivo studies.
Wu DQ, Zhong HM, Ding QH, Ba L
BMC complementary and alternative medicine 2014 Nov 15;14:444
BMC complementary and alternative medicine 2014 Nov 15;14:444
Chondroprotective effects and multi-target mechanisms of Icariin in IL-1 beta-induced human SW 1353 chondrosarcoma cells and a rat osteoarthritis model.
Zeng L, Wang W, Rong XF, Zhong Y, Jia P, Zhou GQ, Li RH
International immunopharmacology 2014 Jan;18(1):175-81
International immunopharmacology 2014 Jan;18(1):175-81
Loss of Vhl in cartilage accelerated the progression of age-associated and surgically induced murine osteoarthritis.
Weng T, Xie Y, Yi L, Huang J, Luo F, Du X, Chen L, Liu C, Chen D, Chen L
Osteoarthritis and cartilage 2014 Aug;22(8):1197-205
Osteoarthritis and cartilage 2014 Aug;22(8):1197-205
Suppression of hyaluronan synthesis alleviates inflammatory responses in murine arthritis and in human rheumatoid synovial fibroblasts.
Yoshioka Y, Kozawa E, Urakawa H, Arai E, Futamura N, Zhuo L, Kimata K, Ishiguro N, Nishida Y
Arthritis and rheumatism 2013 May;65(5):1160-70
Arthritis and rheumatism 2013 May;65(5):1160-70
Celastrol, an inhibitor of heat shock protein 90β potently suppresses the expression of matrix metalloproteinases, inducible nitric oxide synthase and cyclooxygenase-2 in primary human osteoarthritic chondrocytes.
Ding QH, Cheng Y, Chen WP, Zhong HM, Wang XH
European journal of pharmacology 2013 May 15;708(1-3):1-7
European journal of pharmacology 2013 May 15;708(1-3):1-7
Anti-arthritic effects of crocin in interleukin-1β-treated articular chondrocytes and cartilage in a rabbit osteoarthritic model.
Ding Q, Zhong H, Qi Y, Cheng Y, Li W, Yan S, Wang X
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2013 Jan;62(1):17-25
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2013 Jan;62(1):17-25
Genetic inhibition of fibroblast growth factor receptor 1 in knee cartilage attenuates the degeneration of articular cartilage in adult mice.
Weng T, Yi L, Huang J, Luo F, Wen X, Du X, Chen Q, Deng C, Chen D, Chen L
Arthritis and rheumatism 2012 Dec;64(12):3982-92
Arthritis and rheumatism 2012 Dec;64(12):3982-92
Drug delivery from internally implanted biomedical devices used in traumatology and in orthopedic surgery.
Arruebo M, Vilaboa N, Santamaria J
Expert opinion on drug delivery 2010 May;7(5):589-603
Expert opinion on drug delivery 2010 May;7(5):589-603
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- MDA-MB-453s cells were subjected to SDS PAGE followed by western blot with 18165-1-AP( MMP13 Antibody) at dilution of 1:600
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human breast cancer using 18165-1-AP(MMP13 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The MMP13 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human MMP13. This antibody recognizes human,mouse,rat,zebrafish antigen. The MMP13 antibody has been validated for the following applications: ELISA, IHC, WB analysis.
