MMP13

This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. Mutations in this gene are associated with metaphyseal anadysplasia. This gene is part of a cluster of MMP genes on chromosome 11. [provided by RefSeq, Jan 2016]

Description

Matrix metallopeptidase 13

Tissue specificity

Tissue enriched (urinary bladder)

Predicted location

Secreted to extracellular matrix

Protein family

Cancer-related genes
Disease related genes
Enzymes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Potential drug targets
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

11 (102942995 - 102955732)

Ensembl ID

ENSG00000137745  (ver. 103.38)

Orthologs

Mouse Mmp13: ENSMUSG00000050578

UniProt

P45452

neXtProt

NX_P45452

Human splice variants
Mouse splice variants

Protein structure