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- References [24]
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- Western blot [1]
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- Product number
- 11856-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11856-1-AP, RRID:AB_2070053
- Product name
- Caspase 4/p20/p10 antibody
- Antibody type
- Polyclonal
- Description
- Caspase 4/p20/p10 antibody (Cat. #11856-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Molecular Mechanism of Caspase-8-Dependent Interleukin-18 Activation in Pancreatic Cancer Cells Induced by 5-Fluorouracil and Nutrient Starvation.
Selenium accumulated exposure aggravates the progression of type 2 diabetes mellitus via activating the IRF2/Caspase-4/GSDMD pyroptosis pathway.
Caspase-4/11-mediated non-canonical pyroptosis disrupts blood-brain barrier integrity via VEGFA/VEGFR2 signaling in Escherichia coli meningitis.
The TRAF6-TXNIP-NLRP3 signaling axis regulates LPS-induced pyroptosis in glomerular podocytes.
Aurantii Fructus alleviates depression via modulating hippocampal caspase-4-linked neurogenesis and synaptic plasticity in mice.
Micro-/nano-structured zirconia surface promotes osteogenic differentiation of human bone marrow mesenchymal stem cells by reducing pyroptosis under inflammatory conditions.
Integrated Multi-Omics Profiling Reveals That Highly Pyroptotic MDMs Contribute to Psoriasis Progression Through CXCL16.
Diagnostic PANoptosis-related genes in acute kidney injury: bioinformatics, machine learning, and validation.
GSDMB involvement in the pathogenesis of abdominal aortic aneurysm through regulation of macrophage non-canonical pyroptosis.
Palmitic acid induces GSDMD-mediated pyroptosis in periodontal ligament cells via the NF-κB pathway.
Regulation of NLRP3 inflammasome and Caspase-3/4/11 by 2',4'-dihydroxychalcone contributes to anti-colorectal cancer.
Outer membrane vesicles derived from gut microbiota mediate tubulointerstitial inflammation: a potential new mechanism for diabetic kidney disease.
A Pyroptosis-Related Gene Signature Associated with Prognosis and Tumor Immune Microenvironment in Gliomas.
Crosstalk of necroptosis and pyroptosis defines tumor microenvironment characterization and predicts prognosis in clear cell renal carcinoma.
VX-765 ameliorates renal injury and fibrosis in diabetes by regulating caspase-1-mediated pyroptosis and inflammation.
Enterovirus 71 Induces INF2 Cleavage via Activated Caspase-2 in Infected RD Cells.
IGF2BP2 knockdown inhibits LPS-induced pyroptosis in BEAS-2B cells by targeting caspase 4, a crucial molecule of the non-canonical pyroptosis pathway.
Aspergillus fumigatus-Stimulated Human Corneal Epithelial Cells Induce Pyroptosis of THP-1 Macrophages by Secreting TSLP.
The Role of Caspase-4 and NLRP1 in MCF7 Cell Pyroptosis Induced by hUCMSC-Secreted Factors.
Porphyromonas gingivalis-Induced NLRP3 Inflammasome Activation and Its Downstream Interleukin-1β Release Depend on Caspase-4.
Effects of autophage on the proliferation and apoptosis of clear cell renal carcinoma 786-O cells.
Mechanisms of IFNalpha-1a-Induced Apoptosis in a Laryngeal Cancer Cell Line.
Atypical Gasdermin D and Mixed Lineage Kinase Domain-like Protein Leakage Aggravates Tetrachlorobenzoquinone-Induced Nod-like Receptor Protein 3 Inflammasome Activation.
Interferon α Induces the Apoptosis of Cervical Cancer HeLa Cells by Activating both the Intrinsic Mitochondrial Pathway and Endoplasmic Reticulum Stress-Induced Pathway.
Kamino H, Nariai Y, Urano T
Genes to cells : devoted to molecular & cellular mechanisms 2026 May;31(3):e70111
Genes to cells : devoted to molecular & cellular mechanisms 2026 May;31(3):e70111
Selenium accumulated exposure aggravates the progression of type 2 diabetes mellitus via activating the IRF2/Caspase-4/GSDMD pyroptosis pathway.
Wei L, Li Z, Shan J, Chen X, Zhou H, Zhong J, Yang Y, Chi J, Zhang B, Liang H, Mo Z, Xie L, Lin R, Lv Y, Li S, Zhang H
The Journal of nutritional biochemistry 2026 Jul;153:110326
The Journal of nutritional biochemistry 2026 Jul;153:110326
Caspase-4/11-mediated non-canonical pyroptosis disrupts blood-brain barrier integrity via VEGFA/VEGFR2 signaling in Escherichia coli meningitis.
Du Y, Yu X, Lu Y, Jia K, Peng L, Fang R, Zhang J, Li Z
Microbiological research 2026 Aug;309:128531
Microbiological research 2026 Aug;309:128531
The TRAF6-TXNIP-NLRP3 signaling axis regulates LPS-induced pyroptosis in glomerular podocytes.
Ye C, Liu H, Ming Z, Yi Q, Xiang R, Chen Y
Journal of molecular histology 2026 Apr 20;57(3)
Journal of molecular histology 2026 Apr 20;57(3)
Aurantii Fructus alleviates depression via modulating hippocampal caspase-4-linked neurogenesis and synaptic plasticity in mice.
Wu L, Tian L, Wei Z, Jiang Y, Shao M, Zhu Y, Sun Y, Lu C
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120406
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120406
Micro-/nano-structured zirconia surface promotes osteogenic differentiation of human bone marrow mesenchymal stem cells by reducing pyroptosis under inflammatory conditions.
Wang HM, Ding Q, Chen Y, Zhang YJ, Wu ZX, Zhang X, Zhang L
Journal of dental sciences 2025 Jul;20(3):1422-1435
Journal of dental sciences 2025 Jul;20(3):1422-1435
Integrated Multi-Omics Profiling Reveals That Highly Pyroptotic MDMs Contribute to Psoriasis Progression Through CXCL16.
Jin L, Xie X, Zhang M, Zhu W, Zhang G, Chen W
Biomedicines 2025 Jul 18;13(7)
Biomedicines 2025 Jul 18;13(7)
Diagnostic PANoptosis-related genes in acute kidney injury: bioinformatics, machine learning, and validation.
Chen Z, Wang X, Shao Y, Wang K, Xue D
Annals of medicine 2025 Dec;57(1):2553930
Annals of medicine 2025 Dec;57(1):2553930
GSDMB involvement in the pathogenesis of abdominal aortic aneurysm through regulation of macrophage non-canonical pyroptosis.
Xie X, Shen X, Liu Y, Zuo Y, Wang S, Zhou Y, Li X, Wang K, Li B, Wang Z
Archives of biochemistry and biophysics 2024 Sep;759:110102
Archives of biochemistry and biophysics 2024 Sep;759:110102
Palmitic acid induces GSDMD-mediated pyroptosis in periodontal ligament cells via the NF-κB pathway.
Sun BJ, Chen MH, Zhang WH, Zhao BJ, Zhang MH, Han XX, Yu LM, Liu YH
Oral diseases 2024 May;30(4):2546-2557
Oral diseases 2024 May;30(4):2546-2557
Regulation of NLRP3 inflammasome and Caspase-3/4/11 by 2',4'-dihydroxychalcone contributes to anti-colorectal cancer.
Zhang G, Yao Y, Zhang Z, Xiao J, Yu H, Zhao J, Yao C, Wang Y, Luo H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156194
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156194
Outer membrane vesicles derived from gut microbiota mediate tubulointerstitial inflammation: a potential new mechanism for diabetic kidney disease.
Chen PP, Zhang JX, Li XQ, Li L, Wu QY, Liu L, Wang GH, Ruan XZ, Ma KL
Theranostics 2023;13(12):3988-4003
Theranostics 2023;13(12):3988-4003
A Pyroptosis-Related Gene Signature Associated with Prognosis and Tumor Immune Microenvironment in Gliomas.
Zhou Z, Xu J, Huang N, Tang J, Ma P, Cheng Y
International journal of general medicine 2022;15:4753-4769
International journal of general medicine 2022;15:4753-4769
Crosstalk of necroptosis and pyroptosis defines tumor microenvironment characterization and predicts prognosis in clear cell renal carcinoma.
Fu L, Bao J, Li J, Li Q, Lin H, Zhou Y, Li J, Yan Y, Langston ME, Sun T, Guo S, Zhou X, Chen Y, Liu Y, Zhao Y, Lu J, Huang Y, Chen W, Chung BI, Luo J
Frontiers in immunology 2022;13:1021935
Frontiers in immunology 2022;13:1021935
VX-765 ameliorates renal injury and fibrosis in diabetes by regulating caspase-1-mediated pyroptosis and inflammation.
Wen S, Deng F, Li L, Xu L, Li X, Fan Q
Journal of diabetes investigation 2022 Jan;13(1):22-33
Journal of diabetes investigation 2022 Jan;13(1):22-33
Enterovirus 71 Induces INF2 Cleavage via Activated Caspase-2 in Infected RD Cells.
Wang B, Zhang C, Yu C, Zhu Y, Tang Q, Huang H, Zhao Z
Frontiers in microbiology 2021;12:684953
Frontiers in microbiology 2021;12:684953
IGF2BP2 knockdown inhibits LPS-induced pyroptosis in BEAS-2B cells by targeting caspase 4, a crucial molecule of the non-canonical pyroptosis pathway.
Wang J, Yuan X, Ding N
Experimental and therapeutic medicine 2021 Jun;21(6):593
Experimental and therapeutic medicine 2021 Jun;21(6):593
Aspergillus fumigatus-Stimulated Human Corneal Epithelial Cells Induce Pyroptosis of THP-1 Macrophages by Secreting TSLP.
Ji Q, Wang L, Liu J, Wu Y, Lv H, Wen Y, Shi L, Qu B, Szentmáry N
Inflammation 2021 Apr;44(2):682-692
Inflammation 2021 Apr;44(2):682-692
The Role of Caspase-4 and NLRP1 in MCF7 Cell Pyroptosis Induced by hUCMSC-Secreted Factors.
Jiao Y, Wang L, Lu L, Liu J, Li X, Zhao H, Hou Z, Zheng B
Stem cells international 2020;2020:8867115
Stem cells international 2020;2020:8867115
Porphyromonas gingivalis-Induced NLRP3 Inflammasome Activation and Its Downstream Interleukin-1β Release Depend on Caspase-4.
Ding PH, Yang MX, Wang NN, Jin LJ, Dong Y, Cai X, Chen LL
Frontiers in microbiology 2020;11:1881
Frontiers in microbiology 2020;11:1881
Effects of autophage on the proliferation and apoptosis of clear cell renal carcinoma 786-O cells.
Wang Z, Deng Q, Wang Z, Chong T
International journal of clinical and experimental pathology 2019;12(4):1342-1349
International journal of clinical and experimental pathology 2019;12(4):1342-1349
Mechanisms of IFNalpha-1a-Induced Apoptosis in a Laryngeal Cancer Cell Line.
Xin XL, Zhang R, Yuan XM, Liu L
Medical science monitor : international medical journal of experimental and clinical research 2019 Sep 22;25:7100-7114
Medical science monitor : international medical journal of experimental and clinical research 2019 Sep 22;25:7100-7114
Atypical Gasdermin D and Mixed Lineage Kinase Domain-like Protein Leakage Aggravates Tetrachlorobenzoquinone-Induced Nod-like Receptor Protein 3 Inflammasome Activation.
Xia X, Lu B, Dong W, Yang B, Wang Y, Qin Q, Liu Z, Song E, Song Y
Chemical research in toxicology 2018 Dec 17;31(12):1418-1425
Chemical research in toxicology 2018 Dec 17;31(12):1418-1425
Interferon α Induces the Apoptosis of Cervical Cancer HeLa Cells by Activating both the Intrinsic Mitochondrial Pathway and Endoplasmic Reticulum Stress-Induced Pathway.
Shi WY, Cao C, Liu L
International journal of molecular sciences 2016 Nov 2;17(11)
International journal of molecular sciences 2016 Nov 2;17(11)
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- SGC-7901 cells were subjected to SDS PAGE followed by western blot with 11856-1-AP(CASP4 antibody) at dilution of 1:300
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Caspase 4 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Caspase 4. This antibody recognizes human antigen. The Caspase 4 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
