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- Antibody Data
- Antigen structure
- References [23]
- Comments [0]
- Validations
- Western blot [5]
- Immunohistochemistry [1]
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- Product number
- ABIN265762 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) antibody
- Antibody type
- Monoclonal
- Description
- Protein G purified
- Reactivity
- Human, Mouse
- Host
- Rat
- Isotype
- IgG
- Antibody clone number
- 17D9
- Vial size
- 0.1 mL
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
- Handling
- Avoid freeze-thaw cycles
Submitted references cGAS drives noncanonical-inflammasome activation in age-related macular degeneration.
Caspase-11-mediated endothelial pyroptosis underlies endotoxemia-induced lung injury.
Lipopolysaccharide-primed heterotolerant dendritic cells suppress experimental autoimmune uveoretinitis by multiple mechanisms.
Differential roles of caspase-1 and caspase-11 in infection and inflammation.
Differential Sensitivity of Target Genes to Translational Repression by miR-17~92.
NLRP3 regulates a non-canonical platform for caspase-8 activation during epithelial cell apoptosis.
SESN2/sestrin2 suppresses sepsis by inducing mitophagy and inhibiting NLRP3 activation in macrophages.
Canonical Inflammasomes Drive IFN-γ to Prime Caspase-11 in Defense against a Cytosol-Invasive Bacterium.
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling.
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death.
The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease.
Escherichia coli α-hemolysin counteracts the anti-virulence innate immune response triggered by the Rho GTPase activating toxin CNF1 during bacteremia.
Molecular mechanisms of cell death: central implication of ATP synthase in mitochondrial permeability transition.
Activation of the NLRP1b inflammasome independently of ASC-mediated caspase-1 autoproteolysis and speck formation.
Triggering receptor expressed on myeloid cells 1 (TREM-1)-mediated Bcl-2 induction prolongs macrophage survival.
FADD and caspase-8 mediate priming and activation of the canonical and noncanonical Nlrp3 inflammasomes.
Caspase-11 stimulates rapid flagellin-independent pyroptosis in response to Legionella pneumophila.
MicroRNA-17~92 plays a causative role in lymphomagenesis by coordinating multiple oncogenic pathways.
Microglial cathepsin B contributes to the initiation of peripheral inflammation-induced chronic pain.
An inactivating caspase 11 passenger mutation originating from the 129 murine strain in mice targeted for c-IAP1.
Non-canonical inflammasome activation targets caspase-11.
Distinct downstream pathways of caspase-11 in regulating apoptosis and cytokine maturation during septic shock response.
Dual role of caspase-11 in mediating activation of caspase-1 and caspase-3 under pathological conditions.
Kerur N, Fukuda S, Banerjee D, Kim Y, Fu D, Apicella I, Varshney A, Yasuma R, Fowler BJ, Baghdasaryan E, Marion KM, Huang X, Yasuma T, Hirano Y, Serbulea V, Ambati M, Ambati VL, Kajiwara Y, Ambati K, Hirahara S, Bastos-Carvalho A, Ogura Y, Terasaki H, Oshika T, Kim KB, Hinton DR, Leitinger N, Cambier JC, Buxbaum JD, Kenney MC, Jazwinski SM, Nagai H, Hara I, West AP, Fitzgerald KA, Sadda SR, Gelfand BD, Ambati J
Nature medicine 2018 Jan;24(1):50-61
Nature medicine 2018 Jan;24(1):50-61
Caspase-11-mediated endothelial pyroptosis underlies endotoxemia-induced lung injury.
Cheng KT, Xiong S, Ye Z, Hong Z, Di A, Tsang KM, Gao X, An S, Mittal M, Vogel SM, Miao EA, Rehman J, Malik AB
The Journal of clinical investigation 2017 Nov 1;127(11):4124-4135
The Journal of clinical investigation 2017 Nov 1;127(11):4124-4135
Lipopolysaccharide-primed heterotolerant dendritic cells suppress experimental autoimmune uveoretinitis by multiple mechanisms.
Klaska IP, Muckersie E, Martin-Granados C, Christofi M, Forrester JV
Immunology 2017 Mar;150(3):364-377
Immunology 2017 Mar;150(3):364-377
Differential roles of caspase-1 and caspase-11 in infection and inflammation.
Man SM, Karki R, Briard B, Burton A, Gingras S, Pelletier S, Kanneganti TD
Scientific reports 2017 Mar 27;7:45126
Scientific reports 2017 Mar 27;7:45126
Differential Sensitivity of Target Genes to Translational Repression by miR-17~92.
Jin HY, Oda H, Chen P, Yang C, Zhou X, Kang SG, Valentine E, Kefauver JM, Liao L, Zhang Y, Gonzalez-Martin A, Shepherd J, Morgan GJ, Mondala TS, Head SR, Kim PH, Xiao N, Fu G, Liu WH, Han J, Williamson JR, Xiao C
PLoS genetics 2017 Feb;13(2):e1006623
PLoS genetics 2017 Feb;13(2):e1006623
NLRP3 regulates a non-canonical platform for caspase-8 activation during epithelial cell apoptosis.
Chung H, Vilaysane A, Lau A, Stahl M, Morampudi V, Bondzi-Simpson A, Platnich JM, Bracey NA, French MC, Beck PL, Chun J, Vallance BA, Muruve DA
Cell death and differentiation 2016 Aug;23(8):1331-46
Cell death and differentiation 2016 Aug;23(8):1331-46
SESN2/sestrin2 suppresses sepsis by inducing mitophagy and inhibiting NLRP3 activation in macrophages.
Kim MJ, Bae SH, Ryu JC, Kwon Y, Oh JH, Kwon J, Moon JS, Kim K, Miyawaki A, Lee MG, Shin J, Kim YS, Kim CH, Ryter SW, Choi AM, Rhee SG, Ryu JH, Yoon JH
Autophagy 2016 Aug 2;12(8):1272-91
Autophagy 2016 Aug 2;12(8):1272-91
Canonical Inflammasomes Drive IFN-γ to Prime Caspase-11 in Defense against a Cytosol-Invasive Bacterium.
Aachoui Y, Kajiwara Y, Leaf IA, Mao D, Ting JP, Coers J, Aderem A, Buxbaum JD, Miao EA
Cell host & microbe 2015 Sep 9;18(3):320-32
Cell host & microbe 2015 Sep 9;18(3):320-32
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling.
Kayagaki N, Stowe IB, Lee BL, O'Rourke K, Anderson K, Warming S, Cuellar T, Haley B, Roose-Girma M, Phung QT, Liu PS, Lill JR, Li H, Wu J, Kummerfeld S, Zhang J, Lee WP, Snipas SJ, Salvesen GS, Morris LX, Fitzgerald L, Zhang Y, Bertram EM, Goodnow CC, Dixit VM
Nature 2015 Oct 29;526(7575):666-71
Nature 2015 Oct 29;526(7575):666-71
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death.
Shi J, Zhao Y, Wang K, Shi X, Wang Y, Huang H, Zhuang Y, Cai T, Wang F, Shao F
Nature 2015 Oct 29;526(7575):660-5
Nature 2015 Oct 29;526(7575):660-5
The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease.
Youm YH, Nguyen KY, Grant RW, Goldberg EL, Bodogai M, Kim D, D'Agostino D, Planavsky N, Lupfer C, Kanneganti TD, Kang S, Horvath TL, Fahmy TM, Crawford PA, Biragyn A, Alnemri E, Dixit VD
Nature medicine 2015 Mar;21(3):263-9
Nature medicine 2015 Mar;21(3):263-9
Escherichia coli α-hemolysin counteracts the anti-virulence innate immune response triggered by the Rho GTPase activating toxin CNF1 during bacteremia.
Diabate M, Munro P, Garcia E, Jacquel A, Michel G, Obba S, Goncalves D, Luci C, Marchetti S, Demon D, Degos C, Bechah Y, Mege JL, Lamkanfi M, Auberger P, Gorvel JP, Stuart LM, Landraud L, Lemichez E, Boyer L
PLoS pathogens 2015 Mar;11(3):e1004732
PLoS pathogens 2015 Mar;11(3):e1004732
Molecular mechanisms of cell death: central implication of ATP synthase in mitochondrial permeability transition.
Bonora M, Wieckowsk MR, Chinopoulos C, Kepp O, Kroemer G, Galluzzi L, Pinton P
Oncogene 2015 Mar 19;34(12):1608
Oncogene 2015 Mar 19;34(12):1608
Activation of the NLRP1b inflammasome independently of ASC-mediated caspase-1 autoproteolysis and speck formation.
Van Opdenbosch N, Gurung P, Vande Walle L, Fossoul A, Kanneganti TD, Lamkanfi M
Nature communications 2014;5:3209
Nature communications 2014;5:3209
Triggering receptor expressed on myeloid cells 1 (TREM-1)-mediated Bcl-2 induction prolongs macrophage survival.
Yuan Z, Syed MA, Panchal D, Joo M, Colonna M, Brantly M, Sadikot RT
The Journal of biological chemistry 2014 May 23;289(21):15118-29
The Journal of biological chemistry 2014 May 23;289(21):15118-29
FADD and caspase-8 mediate priming and activation of the canonical and noncanonical Nlrp3 inflammasomes.
Gurung P, Anand PK, Malireddi RK, Vande Walle L, Van Opdenbosch N, Dillon CP, Weinlich R, Green DR, Lamkanfi M, Kanneganti TD
Journal of immunology (Baltimore, Md. : 1950) 2014 Feb 15;192(4):1835-46
Journal of immunology (Baltimore, Md. : 1950) 2014 Feb 15;192(4):1835-46
Caspase-11 stimulates rapid flagellin-independent pyroptosis in response to Legionella pneumophila.
Case CL, Kohler LJ, Lima JB, Strowig T, de Zoete MR, Flavell RA, Zamboni DS, Roy CR
Proceedings of the National Academy of Sciences of the United States of America 2013 Jan 29;110(5):1851-6
Proceedings of the National Academy of Sciences of the United States of America 2013 Jan 29;110(5):1851-6
MicroRNA-17~92 plays a causative role in lymphomagenesis by coordinating multiple oncogenic pathways.
Jin HY, Oda H, Lai M, Skalsky RL, Bethel K, Shepherd J, Kang SG, Liu WH, Sabouri-Ghomi M, Cullen BR, Rajewsky K, Xiao C
The EMBO journal 2013 Aug 28;32(17):2377-91
The EMBO journal 2013 Aug 28;32(17):2377-91
Microglial cathepsin B contributes to the initiation of peripheral inflammation-induced chronic pain.
Sun L, Wu Z, Hayashi Y, Peters C, Tsuda M, Inoue K, Nakanishi H
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Aug 15;32(33):11330-42
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Aug 15;32(33):11330-42
An inactivating caspase 11 passenger mutation originating from the 129 murine strain in mice targeted for c-IAP1.
Kenneth NS, Younger JM, Hughes ED, Marcotte D, Barker PA, Saunders TL, Duckett CS
The Biochemical journal 2012 Apr 15;443(2):355-9
The Biochemical journal 2012 Apr 15;443(2):355-9
Non-canonical inflammasome activation targets caspase-11.
Kayagaki N, Warming S, Lamkanfi M, Vande Walle L, Louie S, Dong J, Newton K, Qu Y, Liu J, Heldens S, Zhang J, Lee WP, Roose-Girma M, Dixit VM
Nature 2011 Oct 16;479(7371):117-21
Nature 2011 Oct 16;479(7371):117-21
Distinct downstream pathways of caspase-11 in regulating apoptosis and cytokine maturation during septic shock response.
Kang SJ, Wang S, Kuida K, Yuan J
Cell death and differentiation 2002 Oct;9(10):1115-25
Cell death and differentiation 2002 Oct;9(10):1115-25
Dual role of caspase-11 in mediating activation of caspase-1 and caspase-3 under pathological conditions.
Kang SJ, Wang S, Hara H, Peterson EP, Namura S, Amin-Hanjani S, Huang Z, Srinivasan A, Tomaselli KJ, Thornberry NA, Moskowitz MA, Yuan J
The Journal of cell biology 2000 May 1;149(3):613-22
The Journal of cell biology 2000 May 1;149(3):613-22
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Supportive validation
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