CASP5

gene product
ICE(rel)III
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Aug 2010]
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Novus Biologicals
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antibodies-online
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Enzo Life Sciences
5 antibodies
Invitrogen Antibodies
7 antibodies
OriGene
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Rockland Immunochemicals, Inc.
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Cell Signaling Technology, Inc
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RabMAbs
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Creative Diagnostics
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Creative Biolabs
4 antibodies
Abbkine Scientific Co.Ltd.
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Bioworld Technology, Inc
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MyBioSource
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Atlas Antibodies
1 antibody
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St John's Laboratory
2 antibodies
Leading Biology
4 antibodies
Abbiotec
2 antibodies
RayBiotech, Inc.
3 antibodies
GenWay
8 antibodies
Sigma-Aldrich
3 antibodies
Exalpha Biologicals, Inc.
2 antibodies
EMD Millipore
1 antibody
Abbexa
3 antibodies