abx304984

antibody from Abbexa

Targeting: PSMC3 TBP-1, TBP1

No application information provided.

Antibody Data

Product number

abx304984

Provider

Abbexa

Product name

26S Proteasome Regulatory Subunit 6A (PSMC3) Antibody (FITC)

Antibody type

Polyclonal

Description

26S Proteasome Regulatory Subunit 6A (PSMC3) Antibody (FITC) is a Rabbit Polyclonal against 26S Proteasome Regulatory Subunit 6A (PSMC3) conjugated to FITC. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9.

Reactivity

Human

Host

Rabbit

Conjugate

Green dye

Isotype

IgG

Vial size

100 µg

Storage

Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles.