CHRM2

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]

Description

Cholinergic receptor muscarinic 2

Tissue specificity

Tissue enhanced (heart muscle, intestine)

Predicted location

Membrane

Protein family

Disease related genes
FDA approved drug targets
G-protein coupled receptors
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Kim et al 2014)

Chromosome

7 (136868652 - 137020255)

Ensembl ID

ENSG00000181072  (ver. 103.38)

Orthologs

Mouse Chrm2: ENSMUSG00000045613

UniProt

P08172

neXtProt

NX_P08172

Human splice variants
Mouse splice variants

Protein structure