DLAT

gene product
DLTA, PDC-E2
This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure. Mutations in this gene are also a cause of pyruvate dehydrogenase E2 deficiency which causes primary lactic acidosis in infancy and early childhood. [provided by RefSeq, Oct 2009]
More gene data

Featured antibodies

Antibodies

 

Filters

Application

Antibodypedia Validation Initiative

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

  or   Clear
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Validated within AVI
Eligible for validation within AVI
289 antibodies from 26 providers.

Antibody properties

General

Applications

or Cancel
AntibodyRefsTypeWBELICCIPIHCFC
Atlas Antibodies
2 antibodies
Biorbyt
16 antibodies
antibodies-online
95 antibodies
NovoPro Bioscience Inc.
3 antibodies
GeneTex
5 antibodies
Novus Biologicals
7 antibodies
LifeSpan BioSciences, Inc.
64 antibodies
OriGene
4 antibodies
Abgent
1 antibody
Arigo
1 antibody
Invitrogen Antibodies
6 antibodies
Aviva Systems Biology
3 antibodies
St John's Laboratory
5 antibodies
ProSci
2 antibodies
Cell Signaling Technology, Inc
1 antibody
Abnova Corporation
5 antibodies
Bioworld Technology, Inc
2 antibodies
Proteintech Group
1 antibody
Boster Biological Technology
2 antibodies
Creative Biolabs
11 antibodies
Creative Diagnostics
4 antibodies
MyBioSource
5 antibodies
RabMAbs
1 antibody
United States Biological
37 antibodies
Sigma-Aldrich
5 antibodies
GenWay
1 antibody