Tissue expression
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Protein structure

DLAT

Dihydrolipoamide S-acetyltransferase
DLTA, E2, PDC-E2 
This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure. Mutations in this gene are also a cause of pyruvate dehydrogenase E2 deficiency which causes primary lactic acidosis in infancy and early childhood. [provided by RefSeq, Oct 2009]
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407 antibodies from 31 providers.

Antibody properties

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AntibodyRefsTypeWBELICCIPIHCFC
Proteintech Group
1 antibody
NSJ Bioreagents
2 antibodies
Atlas Antibodies
2 antibodies
Invitrogen Antibodies
20 antibodies
Biorbyt
78 antibodies
FineTest Biotech
1 antibody
Cusabio Biotech Co., Ltd
8 antibodies
St John's Laboratory
5 antibodies
antibodies-online
95 antibodies
NovoPro Bioscience Inc.
3 antibodies
GeneTex
5 antibodies
OriGene
4 antibodies
Abgent
1 antibody
Arigo
1 antibody
Novus Biologicals
7 antibodies
Boster Biological Technology
2 antibodies
Aviva Systems Biology
3 antibodies
ProSci
2 antibodies
Cell Signaling Technology, Inc
1 antibody
Abnova Corporation
5 antibodies
Bioworld Technology, Inc
2 antibodies
Creative Biolabs
20 antibodies
Creative Diagnostics
4 antibodies
MyBioSource
5 antibodies
RabMAbs
1 antibody
United States Biological
37 antibodies
Abbexa
10 antibodies
Leading Biology
2 antibodies
MilliporeSigma / Merck KGaA
7 antibodies
GenWay
1 antibody