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- Product number
- 13426-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13426-1-AP, RRID:AB_2091774
- Product name
- DLAT antibody
- Antibody type
- Polyclonal
- Description
- DLAT antibody (Cat. #13426-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Histone Lactylation Couples FSH-Driven Lactate Metabolism to Mitochondrial Biogenesis by Enhancing HDAC4-Mediated Deacetylation of PGC-1α in Granulosa Cells.
Electroacupuncture Alleviates Oxidative Stress and Cuproptosis in Metabolic Dysfunction-Associated Steatotic Liver Disease Mice Through Activation of the NRF2/ARE Pathway.
Injectable Cu(2+) loaded rhein hydrogel for cross-amplifying osteosarcoma apoptosis and cuproptosis epitranscriptomically.
Dysregulated Copper Metabolism-Induced Cuproptosis Contributes to Mitochondrial Dysfunction and Macrophage Inflammatory Response in Acute Lung Injury.
Hyaluronic acid-coated Cu/Mn Prussian blue nanocubes amplify cuproptosis and cGAS-STING signaling for synergistic prostate cancer therapy.
Glutathione metabolic reprogramming by ferroptosis inducers potentiates cuproptosis and antitumor immunity in osteosarcoma.
Polygonatum Sibiricum polysaccharide ameliorates Alzheimer's disease by alleviating cuproptosis and activating the PI3K/AKT signaling pathway.
Biomineralized Bacterial Biohybrid for Coordinated and Self-Sustained In Situ Synthesis of Antitumor Photothermal Agent and Photosensitizer.
SIRT3 deficiency impairs mitochondrial bioenergetics via hyperacetylation of TCA cycle enzymes in chronic heart failure.
Tudor domain-containing protein 9-targeting siRNA nanoparticles alleviate Pseudomonas aeruginosa lung injury in preclinical models by promoting neutrophil cuproptosis.
Glutathione-depleting mitochondria-targeting nanodrugs for stress amplification and immune activation via synergistic photodynamic therapy and cuproptosis.
Copper depletion ameliorates neuronal damage after intracerebral hemorrhage.
Copper potentiates PUFA-mediated antitumor activity by activating Lipophagy.
Layered double hydroxide nanoplatform synergizes with sonodynamic therapy to induce dual activation of cuproptosis and ferroptosis for breast cancer treatment.
LIAS Promotes Cuproptosis in Prostate Cancer Cells by Suppressing Glycolysis via the p53 Signaling Pathway.
Ginsenoside Ro alleviated cuproptosis induced by high oxalate via inhibiting zinc transporter ZnT1 in renal tubular epithelial cells.
Omeprazole-mediated nanodelivery of copper for synchronous remodeling of copper influx and efflux in cuproptotic glioblastoma therapy.
Xinfeng Capsule ameliorates RA joint injury by inhibiting cuproptosis via the METTL3/miR-221/222-3p/ATP7A Axis.
Cuproptosis of bronchial epithelial cells triggers airway remodeling in chronic asthma.
Tumor lysate-cloaked CuMOF-sorafenib nanoassembler: A synergistic cuproptosis-ferroptosis nanoweapon against tumors.
Nitric oxide-driven copper homeostasis and osteogenesis in cranial defect regeneration using l-arginine-loaded HKUST-1.
SERPINE1-Driven MAPK Activation Enhances Cuproptosis Resistance and Angiogenic Potential in Colorectal Cancer.
PDHA1-acetylation signaling suppresses cuproptosis to attenuate anti-androgen effect in prostate cancer.
Mitochondrial uncoupling sensitizes gastric cancer cells to elesclomol-induced cuproptosis via FDX1/DLAT upregulation.
Unraveling the role of cuproptosis in pulmonary fibrosis pathogenesis and prognosis: an integrative single-cell transcriptomics and microarray analysis.
Transdermal siRNA delivery via biomineralized nanoparticle-incorporated microneedles modulates cuproptosis-ferroptosis interaction for psoriasis therapy.
A precise theranostic nanoplatform amplifies anti-tumor efficacy via copper ionophores and sonodynamic therapy.
Copper-based nanozymes synergistically enhance Cuproptosis for psoriasis treatment.
Multi-Ion Channel Nanomedicines Targeting Zinc Transporter 1/ATPase Copper Transporters Disrupt Copper/Iron Homeostasis to Enhance Tumor Immunotherapy.
Nucleolin-Targeted DNA Nanoflowers Enable Multimodal Synergistic Cancer Therapy.
Yttrium Oxide Nanoparticles Affect Both Cognitive and Memory Function by Disrupting Copper Output in Neuronal Cells in a Rat Model.
To Explore the Mechanism of Cuproptosis in Psoriasis Based on Bioinformatics and in vivo Experiments.
Suppressing chondrocyte cuproptosis by syringaresinol-4-O-β-d-glucoside alleviates gouty arthritis.
Dexmedetomidine alleviates lung ischemia-reperfusion injury by inhibiting cuproptosis: an in vivo study.
Hypoxia, cuproptosis, and osteoarthritis: Unraveling the molecular crosstalk.
LncRNA PVT1 promotes cuproptosis through transcriptional activation of FDX1 in colorectal cancer.
Targeting Dlat-Trpv3 pathway by hyperforin elicits non-canonical promotion of adipose thermogenesis as an effective anti-obesity strategy.
Cuproptosis involvement in neonatal ischemic-hypoxic encephalopathy through the COMMD1/ATP7A signaling axis.
Light-Activated CD36-Targeted Cuproptosis Triggers Metabolic-Immune Synergy for Precision Breast Cancer Therapy.
Antimitochondrial antibodies in systemic sclerosis target enteric neurons and are associated with GI dysmotility.
Cuproptosis is involved in small intestinal toxicity in the paraffins during pregnancy.
Dendritic Cell-Depleted Mice Develop the Autoimmune Biliary Disease That Serologically and Pathogenically Models Human Primary Biliary Cholangitis.
α-Synuclein targeted therapy with multiple pathological improvement for Parkinson's disease by macrocyclic amphiphile nanomedicine.
Microwave-Activated Bacterial Biorobot for Multimodal Cancer Therapy.
A Tumor Microenvironment-Responsive Self-Oxygenating Nanoplatform for Dual-Enhanced Cuproptosis and Sonodynamic Synergistic Immunotherapy.
Targeting cuproptosis by FDX1 in acetaminophen-induced liver injury.
Targeting the cuproptosis‑associated gene COL22A1 in glioblastoma using EMD‑1204831 and kaempferol.
One-Step Symbiosis of Bimetallic Peroxides Nanoparticles to Induce Ferroptosis/Cuproptosis and Activate cGAS-STING Pathway for Enhanced Tumor Immunotherapy.
Induced cuproptosis by targeting the ESCRT-III complex potentiates copper-based control of smut diseases.
Mitochondrial NADPH fuels mitochondrial fatty acid synthesis and lipoylation to power oxidative metabolism.
AKT1 Phosphorylates FDX1 to Promote Cuproptosis Resistance in Triple-Negative Breast Cancer.
Tetrathiomolybdate alleviates bleomycin-induced pulmonary fibrosis by reducing copper concentration and suppressing EMT.
Novel Pt@PCN-Cu-induced cuproptosis amplifies αPD-L1 immunotherapy in pancreatic ductal adenocarcinoma through mitochondrial HK2-mediated PD-L1 upregulation.
Integrated bioinformatics and experiment validation reveal cuproptosis-related biomarkers and therapeutic targets in sepsis-induced myocardial dysfunction.
Pyruvate Regulates the Expression of DLAT to Promote Follicular Growth.
Functional nanozyme system for synergistic tumor immunotherapy via cuproptosis and ferroptosis activation.
Sirtuin3 attenuates pressure overload-induced pathological myocardial remodeling by inhibiting cardiomyocyte cuproptosis.
Mitochondria-localized MBD2c facilitates mtDNA transcription and drug resistance.
Porous Fe/Cu Nanoreactor with Dual Insurance Design for Precision Chemotherapy and Chemodynamic Therapy.
C5a/C5aR pathway blocking promoted CuS-mediated cancer therapy effect by inhibiting cuproptosis resistance.
A Novel Copper Ionophore Nanoshuttle (Winged Cu) for Inducing Cuproptosis in B16 Melanoma Cells.
Copper Peroxide-Ring Stabilized Bicelle Loaded with GSH-Responsive Derivative of Doxorubicin to Induce Amplified Cuproptosis.
Increased CDKN2A expression correlates with resistance to platinum-based therapy and decreased infiltration of B lymphocytes in colon adenocarcinoma.
Mitochondrial thermal proteome profiling reveals aberrant activation of pyruvate dehydrogenase upon cuproptosis.
CuOTeDsP nanotherapeutics enhance cuproptosis-mediated immunotherapy by modulating cholesterol metabolism in bladder cancer.
Copper/calcium co-doped carbon dots for targeted cancer therapy with dual-mode imaging and synergistic induction of cuproptosis and calcium-mediated apoptosis.
Tanshinone IIA induces oxidative stress in trophoblast cells and enhances copper dependent death.
Exploiting mitochondrial dysfunction to overcome BRAF inhibitor resistance in advanced melanoma: the role of disulfiram as a copper ionophore.
Multiorgan proteomic analysis of infected animal models predict potential host factors for chikungunya virus.
Cupric Doping Hollow Prussian Blue Nanoplatform for Enhanced Cholesterol Depletion: a Promising Strategy for Breast Cancer Therapy and Metastasis Inhibition.
Novel insights into cuproptosis in alcoholic liver disease using bioinformatics analysis and experimental validation.
A metal-organic framework functionalized CaO(2)-based cascade nanoreactor induces synergistic cuproptosis/ferroptosis and Ca(2+) overload-mediated mitochondrial damage for enhanced sono-chemodynamic immunotherapy.
Multifunctional drug delivery nanoparticles for combined chemotherapy/chemodynamic/photothermal therapy against colorectal cancer through synergistic cuproptosis/ferroptosis/apoptosis.
Glutathione Induced In Situ Activation of Dual-Locked Cuproptosis Nanoamplifier with Glycolysis Metabolism Inhibition to Boost Cancer Immunotherapy.
Graphene Quantum Dot Sensitized Heterojunctions Induce Tumor-Specific Cuproptosis to Boost Sonodynamic and Chemodynamic Enhanced Cancer Immunotherapy.
Aprocitentan mitigates doxorubicin-induced cardiotoxicity by inhibiting cuproptosis, oxidative stress, and mitochondrial impairments via the activation of sirtuin 7.
A photothermally triggered cascade bioreactor for cuproptosis and ferroptosis-driven cancer immunotherapy.
Regulating SLC7A11/GSH/GPX4 axis by glucose dyshomeostasis to simultaneously promote disulfidptosis, cuproptosis and ferroptosis.
Unraveling the miR-144-3p/PUMA pathway: a novel regulator of FDX1-mediated cuproptosis in colorectal cancer.
Cu-doped dendritic biodegradable nanoplatforms for augmenting cuproptosis and tumor-starvation therapy through mitochondrial metabolic cascade modulation.
Biodegradable Cu-based sonozymes for tumor-specific cuproptosis-enhanced sono-immunotherapy through activating cGAS-STING pathway and sensitizing immune checkpoint blockade.
Clinically friendly smart hydrogel boosts cuproptosis and PD-L1 upregulation to enhance anti-tumor immunotherapy.
Carrier-Free Self-Assembled Nanoparticles for Triple-Amplified Tumor Chemodynamic Therapy and Cuproptosis Induction.
Disruption of NF-κB-Mediated Copper Homeostasis Sensitizes Breast Cancer to Cuproptosis.
Functional nano-nucleic acid platform promotes copper-induced gastric cancer cell death.
LRPPRC-Driven Oxidative Phosphorylation Is Associated with Elesclomol-Induced Cuproptosis in Ovarian Cancer.
Vitisin A inhibits liver fibrosis by promoting Nrf2/HO-1 pathway and inhibiting Cuproptosis.
MTF1 attenuates ferroptosis and cuproptosis synergistic potentiation in gastric cancer.
Melanoma MHC-I-membrane-encapsulated Cu@ferrihydrite induces ferroptosis/cuproptosis and systematic immunity against tumor.
An Activatable Dual-Engine Metabolic Inhibition Switch: Sequential Blockade of Glycolysis and Mitochondrial Respiration Potentiates Photodynamic Therapy via Tumor Reoxygenation.
Immunogenic cuproptosis in cancer immunotherapy via an in situ cuproptosis-inducing system.
High-Efficiency Carriers' Separation Strategy Based Ultrasmall-Bandgap CuWO(4) Sono-Enhances GSH Antagonism for Cuproptosis Cascade Immunotherapy.
Copper-Induced Cuproptosis and Immunogenic Cell Death Synergize with Radiotherapy and PD-1 Blockade in Osteosarcoma.
Triphenylphosphine-Chitosan Functionalized MoS(2) Nanosheets Delivering Elesclomol-Cu(II) Complex for Enhanced Cuproptosis-Mediated Cancer Therapy.
Responsive plasmonic hybrid nanorods enables metabolism reprogramming via cuproptosis-photothermal combined cancer therapy.
Engineering M2 macrophage-derived exosomes modulate activated T cell cuproptosis to promote immune tolerance in rheumatoid arthritis.
Multifunctional porous organic polymer-based hybrid nanoparticles for sonodynamically enhanced cuproptosis and synergistic tumor therapy.
Engineering Dual-Responsive Nanoplatform Achieves Copper Metabolism Disruption and Glutathione Consumption to Provoke Cuproptosis/Ferroptosis/Apoptosis for Cancer Therapy.
Chlorophyllin exerts synergistic anti-tumor effect with gemcitabine in pancreatic cancer by inducing cuproptosis.
Impact of diabetes and metformin on cuproptosis and ferroptosis in breast cancer patients: an immunohistochemical analysis.
Copper-mediated SEC14L3 promotes cuproptosis to inhibit hepatocellular carcinoma growth via ERK/YY1/FDX1 axis.
Serum DLAT Is a Potential Diagnostic Marker in AFP-Negative HCC.
Exploring prognosis and therapeutic strategies for HBV-HCC patients based on disulfidptosis-related genes.
Cuproptosis-related lncRNAs emerge as a novel signature for predicting prognosis in prostate carcinoma and functional experimental validation.
GSH exhaustion via inhibition of xCT-GSH-GPX4 pathway synergistically enhanced DSF/Cu-induced cuproptosis in myelodysplastic syndromes.
Metal-Doping Strategy for Carbon-Based Sonosensitizer in Sonodynamic Therapy of Glioblastoma.
Identification of diagnostic signature and immune infiltration for ischemic cardiomyopathy based on cuproptosis-related genes through bioinformatics analysis and experimental validation.
Novel Insights Into DLAT's Role in Alzheimer's Disease-Related Copper Toxicity Through Microglial Exosome Dynamics.
CuO Nanozymes Catalyze Cysteine and Glutathione Depletion Induced Ferroptosis and Cuproptosis for Synergistic Tumor Therapy.
Three Birds with One Stone: Copper Ions Assisted Synergistic Cuproptosis/Chemodynamic/Photothermal Therapy by a Three-Pronged Approach.
Copper-Based Composites Nanoparticles Improve Triple-Negative Breast Cancer Treatment with Induction of Apoptosis-Cuproptosis and Immune Activation.
Biomimetic Nano-Regulator that Induces Cuproptosis and Lactate-Depletion Mediated ROS Storm for Metalloimmunotherapy of Clear Cell Renal Cell Carcinoma.
Anti-mitochondrial antibodies in systemic sclerosis target enteric neurons and are associated with GI dysmotility.
Inhalable metal-organic framework-mediated cuproptosis combined with PD-L1 checkpoint blockade for lung metastasis synergistic immunotherapy.
Comprehensive molecular analyses of cuproptosis-related genes with regard to prognosis, immune landscape, and response to immune checkpoint blockers in lung adenocarcinoma.
Prognostic value and immunological function of cuproptosis-related genes in lung adenocarcinoma.
Retinoic acid mitigates the NSC319726-induced spermatogenesis dysfunction through cuproptosis-independent mechanisms.
Decreased pyruvate dehydrogenase activity in Tafazzin-deficient cells is caused by dysregulation of pyruvate dehydrogenase phosphatase 1 (PDP1).
Precision targeting of CuET overload to disrupt mitochondrial unfolded protein response by integrated liposome.
Acetyl-CoA production by Mediator-bound 2-ketoacid dehydrogenases boosts de novo histone acetylation and is regulated by nitric oxide.
MUC20 regulated by extrachromosomal circular DNA attenuates proteasome inhibitor resistance of multiple myeloma by modulating cuproptosis.
A cuproptosis-related gene expression signature predicting clinical prognosis and immune responses in intrahepatic cholangiocarcinoma detected by single-cell RNA sequence analysis.
Integrated analysis identifies cuproptosis-related gene DLAT and its competing endogenous RNAs network to predict the prognosis of pancreatic adenocarcinoma patients.
Clinical features and molecular landscape of cuproptosis signature-related molecular subtype in gastric cancer.
Elesclomol-copper synergizes with imidazole ketone erastin by promoting cuproptosis and ferroptosis in myelodysplastic syndromes.
Combating Atherosclerosis with Chirality/Phase Dual-Engineered Nanozyme Featuring Microenvironment-Programmed Senolytic and Senomorphic Actions.
Mitochondrial-Targeted Copper Delivery for Cuproptosis-Based Synergistic Cancer Therapy.
Molecular characterization and clinical relevance of metabolic signature subtypes in gastric cancer.
Biomarker Identification and Risk Prediction Model Development for Differentiated Thyroid Carcinoma Lung Metastasis Based on Primary Lesion Proteomics.
Hypoxia induces mitochondrial protein lactylation to limit oxidative phosphorylation.
Identification of cuproptosis-related molecular classification and characteristic genes in ulcerative colitis.
Engineered Microbial Nanohybrids for Tumor-Mediated NIR II Photothermal Enhanced Ferroptosis/Cuproptosis and Immunotherapy.
Sirtuin 7 ameliorates cuproptosis, myocardial remodeling and heart dysfunction in hypertension through the modulation of YAP/ATP7A signaling.
Tumor Microenvironment Reprogrammed Bimetallic Hybrid Nanostimulator for Triggering Radio-Cuproptosis-Immunotherapy.
Synergistic enhancement of low-dose radiation therapy via cuproptosis and metabolic reprogramming for radiosensitization in in situ hepatocellular carcinoma.
Metabolic shifts in lipid utilization and reciprocal interactions within the lung metastatic niche of triple-negative breast cancer revealed by spatial multi-omics.
Optimization of protocols for immunohistochemical assessment of enteric nervous system in formalin fixed human tissue.
TRIM24-DTNBP1-ATP7A mediated astrocyte cuproptosis in cognition and memory dysfunction caused by Y(2)O(3) NPs.
Inhalable nanoparticles with enhanced cuproptosis and cGAS-STING activation for synergistic lung metastasis immunotherapy.
Helicobacter Pylori-Enhanced hnRNPA2B1 Coordinates with PABPC1 to Promote Non-m(6)A Translation and Gastric Cancer Progression.
Mitochondrial copper overload promotes renal fibrosis via inhibiting pyruvate dehydrogenase activity.
A singular plasmonic-thermoelectric hollow nanostructure inducing apoptosis and cuproptosis for catalytic cancer therapy.
Injectable Hydrogel-Encapsulating Pickering Emulsion for Overcoming Lenvatinib-Resistant Hepatocellular Carcinoma via Cuproptosis Induction and Stemness Inhibition.
Cuproptosis associated cytoskeletal destruction contributes to podocyte injury in chronic kidney disease.
Monocarboxylate transporter 4 deficiency enhances high-intensity interval training-induced metabolic adaptations in skeletal muscle.
Demystifying the landscape of endometrial immune microenvironment in luteal-phase from cuprotosis: Implications for the mechanism and treatment of RPL.
Cellular Trojan Horse initiates bimetallic Fe-Cu MOF-mediated synergistic cuproptosis and ferroptosis against malignancies.
A Y374X TDP43 truncation leads to an altered metabolic profile in amyotrophic lateral sclerosis fibroblasts driven by pyruvate and TCA cycle intermediate alterations.
Prediction of prognosis, immune infiltration, and personalized treatment of hepatocellular carcinoma by analysis of cuproptosis-related long noncoding RNAs and verification in vitro.
ITGB1-mediated molecular landscape and cuproptosis phenotype induced the worse prognosis in diffuse gastric cancer.
Cuproptosis enhances docetaxel chemosensitivity by inhibiting autophagy via the DLAT/mTOR pathway in prostate cancer.
DLAT is a promising prognostic marker and therapeutic target for hepatocellular carcinoma: a comprehensive study based on public databases.
Identification of a novel cuproptosis-related gene signature for rheumatoid arthritis-A prospective study.
Cuproptosis-related gene DLAT serves as a prognostic biomarker for immunotherapy in clear cell renal cell carcinoma: multi-database and experimental verification.
Cuproptosis-Related Gene DLAT as a Novel Biomarker Correlated with Prognosis, Chemoresistance, and Immune Infiltration in Pancreatic Adenocarcinoma: A Preliminary Study Based on Bioinformatics Analysis.
DLAT as a Cuproptosis Promoter and a Molecular Target of Elesclomol in Hepatocellular Carcinoma.
Comprehensive analysis identifies cuproptosis-related gene DLAT as a potential prognostic and immunological biomarker in pancreatic adenocarcinoma.
Molecular subtypes based on cuproptosis-related genes and tumor microenvironment infiltration characteristics in pancreatic adenocarcinoma.
Tetrathiomolybdate Decreases the Expression of Alkaline Phosphatase in Dermal Papilla Cells by Increasing Mitochondrial ROS Production.
Cuproptosis-related molecular patterns and gene (ATP7A) in hepatocellular carcinoma and their relationships with tumor immune microenvironment and clinical features.
Dexmedetomidine enables copper homeostasis in cerebral ischemia/reperfusion via ferredoxin 1.
A novel signature to guide osteosarcoma prognosis and immune microenvironment: Cuproptosis-related lncRNA.
Comprehensive analysis of cuproptosis-related genes in immune infiltration and diagnosis in ulcerative colitis.
Establishment and experimental validation of a novel cuproptosis-related gene signature for prognostic implication in cholangiocarcinoma.
Beneficial effects of aloperine on inflammation and oxidative stress by suppressing necroptosis in lipopolysaccharide-induced acute lung injury mouse model.
A new thinking: deciphering the aberrance and clinical implication of copper-death signatures in clear cell renal cell carcinoma.
Luteolin Improves Cyclophosphamide-Induced Cystitis through TXNIP/NLRP3 and NF-κB Pathways.
Potential hazardous effects of printing room PM2.5 exposure include promotion of lung inflammation and subsequent injury.
RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis.
Wu G, Chen M, Li C, Wei M, Pan Y, He T, Liu Z, Li H, Zhang C, Zhang JQ, Sheng Y, Liu Y, Liu H, Shen M
Research (Washington, D.C.) 2026;9:1045
Research (Washington, D.C.) 2026;9:1045
Electroacupuncture Alleviates Oxidative Stress and Cuproptosis in Metabolic Dysfunction-Associated Steatotic Liver Disease Mice Through Activation of the NRF2/ARE Pathway.
Deng J, Liao C, Liu H, Tang X, Yang Y, Yang Y, Guo X, Zhang S, Xing K, Liao M, Tang C
Diabetes, metabolic syndrome and obesity : targets and therapy 2026;19:568066
Diabetes, metabolic syndrome and obesity : targets and therapy 2026;19:568066
Injectable Cu(2+) loaded rhein hydrogel for cross-amplifying osteosarcoma apoptosis and cuproptosis epitranscriptomically.
Zhu J, Zhou T, Tang X, Gao Y, Teng Q, Zhang Y, Lv Z, Chen X, Zou J, Shi H
Biomaterials 2026 Sep;332:124170
Biomaterials 2026 Sep;332:124170
Dysregulated Copper Metabolism-Induced Cuproptosis Contributes to Mitochondrial Dysfunction and Macrophage Inflammatory Response in Acute Lung Injury.
Chen S, Zhou Z, Wang Y, Yang D, Jiang J, Chen S
Antioxidants & redox signaling 2026 May;44(13-15):770-791
Antioxidants & redox signaling 2026 May;44(13-15):770-791
Hyaluronic acid-coated Cu/Mn Prussian blue nanocubes amplify cuproptosis and cGAS-STING signaling for synergistic prostate cancer therapy.
Yao X, Ruan Y, Rao T, Lin F, Zhang W
International journal of biological macromolecules 2026 May;362:152036
International journal of biological macromolecules 2026 May;362:152036
Glutathione metabolic reprogramming by ferroptosis inducers potentiates cuproptosis and antitumor immunity in osteosarcoma.
Xu S, Zhao Y, Yao J, Chen H, Lyu J, Ding Y, Zeng H, Chen H, Hu C, Zhao C
International immunopharmacology 2026 May 15;177:116495
International immunopharmacology 2026 May 15;177:116495
Polygonatum Sibiricum polysaccharide ameliorates Alzheimer's disease by alleviating cuproptosis and activating the PI3K/AKT signaling pathway.
Wang S, Guo Y, Wang S, Wang Y, Huo S, Li M, Chen Q, Zhang L, Kuang H, Pan J, Liu Y
Journal of ethnopharmacology 2026 May 10;362:121359
Journal of ethnopharmacology 2026 May 10;362:121359
Biomineralized Bacterial Biohybrid for Coordinated and Self-Sustained In Situ Synthesis of Antitumor Photothermal Agent and Photosensitizer.
Jin K, Zhang Y, Huang Y, Yu L, Zhong Y, Niu L, Wu Y
Advanced healthcare materials 2026 Mar;15(10):e04077
Advanced healthcare materials 2026 Mar;15(10):e04077
SIRT3 deficiency impairs mitochondrial bioenergetics via hyperacetylation of TCA cycle enzymes in chronic heart failure.
Liao Y, Tan X, Peng G, Ren Y, Liu R, Liao H, Luo Z, Cao Z, Wu Y, Ashrafizadeh M, Conde J, Duan C, Hu J, Ma R
Journal of translational medicine 2026 Mar 9;24(1)
Journal of translational medicine 2026 Mar 9;24(1)
Tudor domain-containing protein 9-targeting siRNA nanoparticles alleviate Pseudomonas aeruginosa lung injury in preclinical models by promoting neutrophil cuproptosis.
Zhang W, Li H, Jia H, Xuan W, Ding L, Tan Z, Wu Q, Zhao M, Wu X
Nature communications 2026 Mar 6;17(1)
Nature communications 2026 Mar 6;17(1)
Glutathione-depleting mitochondria-targeting nanodrugs for stress amplification and immune activation via synergistic photodynamic therapy and cuproptosis.
Zhang P, Lin H, Guan Q, Xiong S, Tian Z, Wu W, Dai T, Wang X, Ruan J, Yang S, Dou H
Acta biomaterialia 2026 Jun;216:389-402
Acta biomaterialia 2026 Jun;216:389-402
Copper depletion ameliorates neuronal damage after intracerebral hemorrhage.
Zhang W, Wu G, Wang L, Ren S
Neurochemistry international 2026 Jun;196:106150
Neurochemistry international 2026 Jun;196:106150
Copper potentiates PUFA-mediated antitumor activity by activating Lipophagy.
He X, Yang Q, Lin X, Chen Z, Ren K, Yang J, An X, Yang S, Yang L, Xue Q, Chen X, Wang Y, Yu G, Yan D, Chen X
Cellular signalling 2026 Jun;142:112454
Cellular signalling 2026 Jun;142:112454
Layered double hydroxide nanoplatform synergizes with sonodynamic therapy to induce dual activation of cuproptosis and ferroptosis for breast cancer treatment.
Zhu Q, Wang Z, Xia L, Zhou F, Zhou Z, Sun J, Li Y, Wang L, Li Y, Yan L, Mei W, Yang Q, Zhang M, Wang W
Bioorganic chemistry 2026 Jun 15;174:109746
Bioorganic chemistry 2026 Jun 15;174:109746
LIAS Promotes Cuproptosis in Prostate Cancer Cells by Suppressing Glycolysis via the p53 Signaling Pathway.
Tang Z, Guo P, Liu Y
The Prostate 2026 Jan;86(1):12-19
The Prostate 2026 Jan;86(1):12-19
Ginsenoside Ro alleviated cuproptosis induced by high oxalate via inhibiting zinc transporter ZnT1 in renal tubular epithelial cells.
Li C, Zhou Y, Nie Y, Fu J, Zeng J, Zhang S, Han L, Li Z, Yang H, Li S, Yu B, Ying X, Wu W
Journal of ginseng research 2026 Jan;50(1):100908
Journal of ginseng research 2026 Jan;50(1):100908
Omeprazole-mediated nanodelivery of copper for synchronous remodeling of copper influx and efflux in cuproptotic glioblastoma therapy.
Feng W, Weng C, Li C, Yang R, Shi W, Liu Y, Ge P, Zhang H
Acta biomaterialia 2026 Jan;210:499-515
Acta biomaterialia 2026 Jan;210:499-515
Xinfeng Capsule ameliorates RA joint injury by inhibiting cuproptosis via the METTL3/miR-221/222-3p/ATP7A Axis.
Wang H, Wang A, Liu J, Zhu NF, Cao Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157644
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157644
Cuproptosis of bronchial epithelial cells triggers airway remodeling in chronic asthma.
Wang M, Liu C, Li Z, Wang Y, Li Y, Pei F
Scientific reports 2026 Jan 13;16(1):4621
Scientific reports 2026 Jan 13;16(1):4621
Tumor lysate-cloaked CuMOF-sorafenib nanoassembler: A synergistic cuproptosis-ferroptosis nanoweapon against tumors.
Zhang M, Zhang K, Guo S, Chen P, Yang B, Wang X, Lu X, Zhuo Y, Chen S, Yu D, Fu LH, Qi C, Cai K
Materials today. Bio 2026 Feb;36:102623
Materials today. Bio 2026 Feb;36:102623
Nitric oxide-driven copper homeostasis and osteogenesis in cranial defect regeneration using l-arginine-loaded HKUST-1.
Zhou F, Xu Z, Wang Q, Wang D, Bai F, Xiang L, Man Y, Wu Y
Biomaterials 2026 Feb;325:123557
Biomaterials 2026 Feb;325:123557
SERPINE1-Driven MAPK Activation Enhances Cuproptosis Resistance and Angiogenic Potential in Colorectal Cancer.
Gao P, Li H, Luo J, Zhang C, Wei J, Li X, Ma H
Digestive diseases and sciences 2026 Feb 9;
Digestive diseases and sciences 2026 Feb 9;
PDHA1-acetylation signaling suppresses cuproptosis to attenuate anti-androgen effect in prostate cancer.
Zhuang R, Zhou Q, Cheng B, Peng S, Xiong Z, Xie Z, Lin W, Su T, Li Z, Yao K, Wu Z, Huang H, Li K
Cell death & disease 2026 Feb 23;17(1)
Cell death & disease 2026 Feb 23;17(1)
Mitochondrial uncoupling sensitizes gastric cancer cells to elesclomol-induced cuproptosis via FDX1/DLAT upregulation.
Lu Y, Li Y, Sun X, Li X, Zhao S, Fang Y, Qiu W, Luo C, Qi W
Free radical biology & medicine 2026 Feb 16;244:284-295
Free radical biology & medicine 2026 Feb 16;244:284-295
Unraveling the role of cuproptosis in pulmonary fibrosis pathogenesis and prognosis: an integrative single-cell transcriptomics and microarray analysis.
Chen M, Chen J, Zhang J, Zhu Y, Meng X, Yang Z, Wang R
Molecular and cellular biochemistry 2026 Apr;481(4):1857-1874
Molecular and cellular biochemistry 2026 Apr;481(4):1857-1874
Transdermal siRNA delivery via biomineralized nanoparticle-incorporated microneedles modulates cuproptosis-ferroptosis interaction for psoriasis therapy.
Hao L, Yu P, Yan R, Li K, Luo Z, Xiang S, Wang Y, Fang C, Wang G, Ma S, Peng C, Hu S, Liu P
Materials today. Bio 2026 Apr;37:102991
Materials today. Bio 2026 Apr;37:102991
A precise theranostic nanoplatform amplifies anti-tumor efficacy via copper ionophores and sonodynamic therapy.
Luo X, Wang X, Li S, Chen Q, Song J, Chen J
Materials today. Bio 2026 Apr;37:102957
Materials today. Bio 2026 Apr;37:102957
Copper-based nanozymes synergistically enhance Cuproptosis for psoriasis treatment.
Zhou J, Yu N, Yang X, Li S, Huang M, Pang T, Zhong D, Wen Y, Liu H
Materials today. Bio 2026 Apr;37:102855
Materials today. Bio 2026 Apr;37:102855
Multi-Ion Channel Nanomedicines Targeting Zinc Transporter 1/ATPase Copper Transporters Disrupt Copper/Iron Homeostasis to Enhance Tumor Immunotherapy.
Ma G, Li Y, Li X, Yu D, Chao M, Li J, Guo J, Wang K, Liu Z, Sun R, Gao F
ACS nano 2026 Apr 21;20(15):11801-11821
ACS nano 2026 Apr 21;20(15):11801-11821
Nucleolin-Targeted DNA Nanoflowers Enable Multimodal Synergistic Cancer Therapy.
Ren A, Liu H, Tang Z, Zheng P, Hu Q, Huang T
Biomaterials research 2025;29:0254
Biomaterials research 2025;29:0254
Yttrium Oxide Nanoparticles Affect Both Cognitive and Memory Function by Disrupting Copper Output in Neuronal Cells in a Rat Model.
Zheng M, Chen Z, Xie J, Yang Q, Mo M, Chen L
International journal of nanomedicine 2025;20:5799-5815
International journal of nanomedicine 2025;20:5799-5815
To Explore the Mechanism of Cuproptosis in Psoriasis Based on Bioinformatics and in vivo Experiments.
Ma Y, Sun Y, Yao J, Zhang J, Wang H, Yang S
Journal of inflammation research 2025;18:17433-17456
Journal of inflammation research 2025;18:17433-17456
Suppressing chondrocyte cuproptosis by syringaresinol-4-O-β-d-glucoside alleviates gouty arthritis.
Fu S, Du H, Ling X, Wang H, Chen J, Zhang H, Chen W, Liu C, Ma H, Lin C, Ma P, Qin A
Frontiers in pharmacology 2025;16:1565422
Frontiers in pharmacology 2025;16:1565422
Dexmedetomidine alleviates lung ischemia-reperfusion injury by inhibiting cuproptosis: an in vivo study.
Liu H, Wang Z, Qiu T, Du W, Wu Z, Chen S, Jiao W
Frontiers in pharmacology 2025;16:1562535
Frontiers in pharmacology 2025;16:1562535
Hypoxia, cuproptosis, and osteoarthritis: Unraveling the molecular crosstalk.
Jiang Z, Li J, Shi M, Li Y, Sun N, Xi K, Li X, Zhao D, Leng X, Zhou Z, Dong H
Redox biology 2025 Sep;85:103757
Redox biology 2025 Sep;85:103757
LncRNA PVT1 promotes cuproptosis through transcriptional activation of FDX1 in colorectal cancer.
Ma J, Zhang Y, Sun Z, Guo H, Li X, Cai J, Zhang M, Chen M, Jiang J, Zhang L
Redox biology 2025 Sep;85:103722
Redox biology 2025 Sep;85:103722
Targeting Dlat-Trpv3 pathway by hyperforin elicits non-canonical promotion of adipose thermogenesis as an effective anti-obesity strategy.
Lu S, Jiang Q, Zhou P, Yin L, Wang N, Xu J, Qian Q, Tao M, Yin H, Han L, Gu Y, Gao F, Liu J, Chen S
Journal of advanced research 2025 Sep;75:793-809
Journal of advanced research 2025 Sep;75:793-809
Cuproptosis involvement in neonatal ischemic-hypoxic encephalopathy through the COMMD1/ATP7A signaling axis.
Luo J, Zhang X, Bharati L, Hua Z, Chen S, Dong Z
Biochemical pharmacology 2025 Sep;239:117054
Biochemical pharmacology 2025 Sep;239:117054
Light-Activated CD36-Targeted Cuproptosis Triggers Metabolic-Immune Synergy for Precision Breast Cancer Therapy.
Wang S, Shen Y, Hu B, Wu Q, Wang N, Wang Z, Zhang Z, Li Y, Jiang J
ACS applied materials & interfaces 2025 Sep 10;17(36):50317-50336
ACS applied materials & interfaces 2025 Sep 10;17(36):50317-50336
Antimitochondrial antibodies in systemic sclerosis target enteric neurons and are associated with GI dysmotility.
McMahan ZH, Puttapaka SN, Casciola-Rosen L, Kaniecki T, Gutierrez-Alamillo L, Ming SH, Seika P, Kulkarni S
Annals of the rheumatic diseases 2025 Oct;84(10):1721-1732
Annals of the rheumatic diseases 2025 Oct;84(10):1721-1732
Cuproptosis is involved in small intestinal toxicity in the paraffins during pregnancy.
Tang J, Xu Z, Jiang M, Luo C, Li X, Jiang Y, Qu Y, Ruan J, Wang X, Zheng M, Law WC, Zhao X
Toxicology letters 2025 Oct;412:85-94
Toxicology letters 2025 Oct;412:85-94
Dendritic Cell-Depleted Mice Develop the Autoimmune Biliary Disease That Serologically and Pathogenically Models Human Primary Biliary Cholangitis.
Zhang J, Nakagawa R, Xu Q, Hu K, Ru L, Nakagawa H, Hirata Y
Hepatology research : the official journal of the Japan Society of Hepatology 2025 Nov;55(11):1471-1485
Hepatology research : the official journal of the Japan Society of Hepatology 2025 Nov;55(11):1471-1485
α-Synuclein targeted therapy with multiple pathological improvement for Parkinson's disease by macrocyclic amphiphile nanomedicine.
Gao JM, Li WB, Yi Y, Wei JJ, Gong MX, Pan BB, Su XC, Pan YC, Guo DS, Gong QH
Biomaterials 2025 Nov;322:123378
Biomaterials 2025 Nov;322:123378
Microwave-Activated Bacterial Biorobot for Multimodal Cancer Therapy.
Zhuang H, Zhang Y, Fu Y, Ke D, Chen Q, Shao S, Xue P, Chen Y, Zeng X, Yan S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(41):e04603
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(41):e04603
A Tumor Microenvironment-Responsive Self-Oxygenating Nanoplatform for Dual-Enhanced Cuproptosis and Sonodynamic Synergistic Immunotherapy.
Tang Y, Ge L, Zhu D, Hu R, Chen W, Zhen X, Jiang X
ACS nano 2025 Nov 18;19(45):39228-39240
ACS nano 2025 Nov 18;19(45):39228-39240
Targeting cuproptosis by FDX1 in acetaminophen-induced liver injury.
Liu Y, Yang Y, Peng B, Ou Z, Zuo A, Jiang Z, Wu C, Kwan HY, Ma K, Yu L, Zhao X
Chemico-biological interactions 2025 Nov 1;421:111753
Chemico-biological interactions 2025 Nov 1;421:111753
Targeting the cuproptosis‑associated gene COL22A1 in glioblastoma using EMD‑1204831 and kaempferol.
Chen Y, Zhang Y, Yang H, Liu Q, Sui R, Shi J, Liang H, Liu J, Xu H, Piao H
International journal of oncology 2025 May;66(5)
International journal of oncology 2025 May;66(5)
One-Step Symbiosis of Bimetallic Peroxides Nanoparticles to Induce Ferroptosis/Cuproptosis and Activate cGAS-STING Pathway for Enhanced Tumor Immunotherapy.
Liu B, Chen X, Zhu Y, Chen H, Tan J, Yang Z, Li J, Zheng P, Feng L, Wang Q, Gai S, Zhong L, Yang P, Cheng Z, Lin J
Advanced materials (Deerfield Beach, Fla.) 2025 May;37(21):e2500337
Advanced materials (Deerfield Beach, Fla.) 2025 May;37(21):e2500337
Induced cuproptosis by targeting the ESCRT-III complex potentiates copper-based control of smut diseases.
Jia H, Wu R, Li L, Zhang L, Sun X, Feng X, Wang Y, Cai E, Sun S, Chang C
International journal of biological macromolecules 2025 May;305(Pt 2):141292
International journal of biological macromolecules 2025 May;305(Pt 2):141292
Mitochondrial NADPH fuels mitochondrial fatty acid synthesis and lipoylation to power oxidative metabolism.
Kim D, Kesavan R, Ryu K, Dey T, Marckx A, Menezes C, Praharaj PP, Morley S, Ko B, Soflaee MH, Tom HJ, Brown H, Vu HS, Tso SC, Brautigam CA, Lemoff A, Mettlen M, Mishra P, Cai F, Allen DK, Hoxhaj G
Nature cell biology 2025 May;27(5):790-800
Nature cell biology 2025 May;27(5):790-800
AKT1 Phosphorylates FDX1 to Promote Cuproptosis Resistance in Triple-Negative Breast Cancer.
Sun Z, Xu H, Lu G, Yang C, Gao X, Zhang J, Liu X, Chen Y, Wang K, Guo J, Li J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(17):e2408106
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(17):e2408106
Tetrathiomolybdate alleviates bleomycin-induced pulmonary fibrosis by reducing copper concentration and suppressing EMT.
Wang Y, Chen S, Zhou Z, Jiang J, Chen S
European journal of medical research 2025 May 19;30(1):394
European journal of medical research 2025 May 19;30(1):394
Novel Pt@PCN-Cu-induced cuproptosis amplifies αPD-L1 immunotherapy in pancreatic ductal adenocarcinoma through mitochondrial HK2-mediated PD-L1 upregulation.
Wang P, Guo W, Liu S, Li S, Li J, Ding B, Yin F, Yang Y, Li X, Cao P, Ma C, Zhang W, Song Y, Geng Y, Liu L, Hu J, Hao J, Feng Y
Journal of experimental & clinical cancer research : CR 2025 May 17;44(1):149
Journal of experimental & clinical cancer research : CR 2025 May 17;44(1):149
Integrated bioinformatics and experiment validation reveal cuproptosis-related biomarkers and therapeutic targets in sepsis-induced myocardial dysfunction.
Shi X, Yan Z, Ding R, Xia F, Du Y, Wang X, Peng Q
BMC infectious diseases 2025 Mar 31;25(1):445
BMC infectious diseases 2025 Mar 31;25(1):445
Pyruvate Regulates the Expression of DLAT to Promote Follicular Growth.
Zhang L, Guo Y, Huang E, Lu J, Wang T, Shi Y, Lv M, Chen Y, Li S, Yuan X, Li J
Cells 2025 Mar 17;14(6)
Cells 2025 Mar 17;14(6)
Functional nanozyme system for synergistic tumor immunotherapy via cuproptosis and ferroptosis activation.
Gu L, Sun Y, Bai T, Shao S, Tang S, Xue P, Cai W, Qin X, Zeng X, Yan S
Journal of nanobiotechnology 2025 Mar 15;23(1):212
Journal of nanobiotechnology 2025 Mar 15;23(1):212
Sirtuin3 attenuates pressure overload-induced pathological myocardial remodeling by inhibiting cardiomyocyte cuproptosis.
Kong B, Zheng X, Hu Y, Zhao Y, Hai J, Ti Y, Bu P
Pharmacological research 2025 Jun;216:107739
Pharmacological research 2025 Jun;216:107739
Mitochondria-localized MBD2c facilitates mtDNA transcription and drug resistance.
Hao Y, Zhou Z, Liu R, Shen S, Liu H, Zhou Y, Sun Y, Mao Q, Zhang T, Li ST, Liu Z, Chu Y, Sun L, Gao P, Zhang H
Nature chemical biology 2025 Jun;21(6):926-938
Nature chemical biology 2025 Jun;21(6):926-938
Porous Fe/Cu Nanoreactor with Dual Insurance Design for Precision Chemotherapy and Chemodynamic Therapy.
Zhu X, Gao L, Zheng Y, Zhao PF, Wei H, Liu R, Zhao L, Zhang J, Sun Q, Zheng L, Lv H, Yang J, Gong J, Wang Z
Advanced healthcare materials 2025 Jun;14(16):e2405229
Advanced healthcare materials 2025 Jun;14(16):e2405229
C5a/C5aR pathway blocking promoted CuS-mediated cancer therapy effect by inhibiting cuproptosis resistance.
Yang H, Deng B, Han X, Wang L, Zhao J, Zhao Y, Sun Z, Wang S, Liu G, Wu Y, Chen J
Journal for immunotherapy of cancer 2025 Jun 8;13(6)
Journal for immunotherapy of cancer 2025 Jun 8;13(6)
A Novel Copper Ionophore Nanoshuttle (Winged Cu) for Inducing Cuproptosis in B16 Melanoma Cells.
Wu Y, Chang Z, Wang W, Wu C, Pan X, Huang Z
Biomolecules 2025 Jun 18;15(6)
Biomolecules 2025 Jun 18;15(6)
Copper Peroxide-Ring Stabilized Bicelle Loaded with GSH-Responsive Derivative of Doxorubicin to Induce Amplified Cuproptosis.
Fu Y, Hao H, Fang Y, Sun S, Wen S, Liu Y, Tang J, Wang T, Wu M
Advanced healthcare materials 2025 Jul;14(18):e2500691
Advanced healthcare materials 2025 Jul;14(18):e2500691
Increased CDKN2A expression correlates with resistance to platinum-based therapy and decreased infiltration of B lymphocytes in colon adenocarcinoma.
Gu R, Li S, Yu B, Gu J, Guan B, Wu H
Functional & integrative genomics 2025 Jul 3;25(1):144
Functional & integrative genomics 2025 Jul 3;25(1):144
Mitochondrial thermal proteome profiling reveals aberrant activation of pyruvate dehydrogenase upon cuproptosis.
Huang Z, Liu Y, Zeng Y, Wang J, Sun S, Heng Tan CS, Chen PR
Cell reports 2025 Jul 22;44(7):115937
Cell reports 2025 Jul 22;44(7):115937
CuOTeDsP nanotherapeutics enhance cuproptosis-mediated immunotherapy by modulating cholesterol metabolism in bladder cancer.
Cai H, Xue P, Liu S, Ma Y, Zeng X, Yan S, Xu N
Journal of nanobiotechnology 2025 Jul 22;23(1):534
Journal of nanobiotechnology 2025 Jul 22;23(1):534
Copper/calcium co-doped carbon dots for targeted cancer therapy with dual-mode imaging and synergistic induction of cuproptosis and calcium-mediated apoptosis.
Zheng W, Liu Y, Liu J, Zhao Y, Wang P, Wang Y, Wang Y, Lu Z, Liu X, Shi Y, Zhou N, González FE, Sun H, Zhou D, Xu X
Journal of colloid and interface science 2025 Jul 15;690:137337
Journal of colloid and interface science 2025 Jul 15;690:137337
Tanshinone IIA induces oxidative stress in trophoblast cells and enhances copper dependent death.
Du J, Wang X, Zeng Y, Feng J, Yang L, Huang Y, Deng G
Scientific reports 2025 Jul 11;15(1):25012
Scientific reports 2025 Jul 11;15(1):25012
Exploiting mitochondrial dysfunction to overcome BRAF inhibitor resistance in advanced melanoma: the role of disulfiram as a copper ionophore.
Zhao B, Ban F, Li Y, Shi Q, Guo S, Yi X, Wang H, Gao T, Li C, Zhu G
Cell death & disease 2025 Jul 1;16(1):482
Cell death & disease 2025 Jul 1;16(1):482
Multiorgan proteomic analysis of infected animal models predict potential host factors for chikungunya virus.
Lin D, Tang C, Wang J, Yang Y, Yang H, Zhou Y, Yu W, Li B, Huang Q, Wang H, An R, Liang X, Yan Y, Yuan L, Du X, Yuan Y, Li Y, Lu S
MedComm 2025 Jan;6(1):e70013
MedComm 2025 Jan;6(1):e70013
Cupric Doping Hollow Prussian Blue Nanoplatform for Enhanced Cholesterol Depletion: a Promising Strategy for Breast Cancer Therapy and Metastasis Inhibition.
Yan S, Xue P, Sun Y, Bai T, Shao S, Zeng X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jan;12(3):e2409967
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jan;12(3):e2409967
Novel insights into cuproptosis in alcoholic liver disease using bioinformatics analysis and experimental validation.
Pan T, Wu S, Wang S, Wang X, Chen D, Chen Y
International immunopharmacology 2025 Jan 27;146:113828
International immunopharmacology 2025 Jan 27;146:113828
A metal-organic framework functionalized CaO(2)-based cascade nanoreactor induces synergistic cuproptosis/ferroptosis and Ca(2+) overload-mediated mitochondrial damage for enhanced sono-chemodynamic immunotherapy.
Tang C, Liu K, Gao X, Kang H, Xie W, Chang J, Yin L, Kang J
Acta biomaterialia 2025 Jan 24;193:455-473
Acta biomaterialia 2025 Jan 24;193:455-473
Multifunctional drug delivery nanoparticles for combined chemotherapy/chemodynamic/photothermal therapy against colorectal cancer through synergistic cuproptosis/ferroptosis/apoptosis.
Yan X, Liu H, Guo L, Liu C, Zhang S, Wang X, Tang Y, Zhou R, Jiang X, Wang E, Gao S, Xu C
Materials today. Bio 2025 Feb;30:101427
Materials today. Bio 2025 Feb;30:101427
Glutathione Induced In Situ Activation of Dual-Locked Cuproptosis Nanoamplifier with Glycolysis Metabolism Inhibition to Boost Cancer Immunotherapy.
Wu X, Zhang S, Feng M, Sun H, Lan X, Liang W, Liu C, Li Y
Advanced healthcare materials 2025 Feb;14(4):e2403380
Advanced healthcare materials 2025 Feb;14(4):e2403380
Graphene Quantum Dot Sensitized Heterojunctions Induce Tumor-Specific Cuproptosis to Boost Sonodynamic and Chemodynamic Enhanced Cancer Immunotherapy.
Yan L, Chang L, Tian Y, Hu J, Cao Z, Guo X, Geng B
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(7):e2410606
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(7):e2410606
Aprocitentan mitigates doxorubicin-induced cardiotoxicity by inhibiting cuproptosis, oxidative stress, and mitochondrial impairments via the activation of sirtuin 7.
Chen YF, Qi RQ, Zhao L, Liang LR, Song JW, Zhou XY, Chen YH, Wang SY, Wang Q, Liu Y, Dong Y, Liu XY, Li J, Zhong JC
International immunopharmacology 2025 Feb 20;148:114141
International immunopharmacology 2025 Feb 20;148:114141
A photothermally triggered cascade bioreactor for cuproptosis and ferroptosis-driven cancer immunotherapy.
Xu J, Wang Y, Williams GR, Zheng Y, Zhang Y, Wang T, Du C, Wang Y, Wu YL, Zhu LM
Journal of colloid and interface science 2025 Dec;699(Pt 1):138100
Journal of colloid and interface science 2025 Dec;699(Pt 1):138100
Regulating SLC7A11/GSH/GPX4 axis by glucose dyshomeostasis to simultaneously promote disulfidptosis, cuproptosis and ferroptosis.
Zhang M, Zheng H, Jin H, Zhu X, Liu S, Chen Y, Zhang H, Zhang S
Bioactive materials 2025 Dec;54:744-758
Bioactive materials 2025 Dec;54:744-758
Unraveling the miR-144-3p/PUMA pathway: a novel regulator of FDX1-mediated cuproptosis in colorectal cancer.
Jia G, Li J, Jiang M, Liu N, Ding N, Jiang X, Zhang G, Tan X, Kang Y, Zhang L, Wang F, Zhang Y
Cellular oncology (Dordrecht, Netherlands) 2025 Dec;48(6):1693-1710
Cellular oncology (Dordrecht, Netherlands) 2025 Dec;48(6):1693-1710
Cu-doped dendritic biodegradable nanoplatforms for augmenting cuproptosis and tumor-starvation therapy through mitochondrial metabolic cascade modulation.
Shi H, Xie Z, Zhang J, Lu F, Luo H, Guo P, Jiang M, Weng Z, Luo X, Chen B, Huang H, Teng T
Materials today. Bio 2025 Dec;35:102477
Materials today. Bio 2025 Dec;35:102477
Biodegradable Cu-based sonozymes for tumor-specific cuproptosis-enhanced sono-immunotherapy through activating cGAS-STING pathway and sensitizing immune checkpoint blockade.
Wu Y, Xu S, Cai J, Hu J, Pan D, Geng B, Gao W, Wu Y
Materials today. Bio 2025 Dec;35:102397
Materials today. Bio 2025 Dec;35:102397
Clinically friendly smart hydrogel boosts cuproptosis and PD-L1 upregulation to enhance anti-tumor immunotherapy.
Fu B, Li G, Yao Y, Zhang M, Zhong Y, Wang X, Chen Y, Liang W, Wang Y, Lin H, Zhang Y, Du Q, Xu Z, Cui H, Shi L, Chen X, Zhang J
Materials today. Bio 2025 Dec;35:102268
Materials today. Bio 2025 Dec;35:102268
Carrier-Free Self-Assembled Nanoparticles for Triple-Amplified Tumor Chemodynamic Therapy and Cuproptosis Induction.
Cheng J, Chen S, Geng M, Wei X, Meng S, Gong L, Chen K, Wang Z, Liu Y, Li X, Li A, Li X, Dai L
Advanced healthcare materials 2025 Dec;14(32):e2501507
Advanced healthcare materials 2025 Dec;14(32):e2501507
Disruption of NF-κB-Mediated Copper Homeostasis Sensitizes Breast Cancer to Cuproptosis.
Zhang X, Su Y, Yang W, Song Z, Sun Z, Wu X, Chen J, Gao B, Wang Z, Wang L, Jiang Q, Bu L, Li J, Lin Y, Xie W, Li J, Guo J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(47):e06201
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(47):e06201
Functional nano-nucleic acid platform promotes copper-induced gastric cancer cell death.
Zhang H, Ding B, Kou Q
RSC advances 2025 Dec 8;15(57):49643-49651
RSC advances 2025 Dec 8;15(57):49643-49651
LRPPRC-Driven Oxidative Phosphorylation Is Associated with Elesclomol-Induced Cuproptosis in Ovarian Cancer.
Wu Y, Zhang W, Jiang S, Liu S, Su J, Sun L
International journal of molecular sciences 2025 Dec 31;27(1)
International journal of molecular sciences 2025 Dec 31;27(1)
Vitisin A inhibits liver fibrosis by promoting Nrf2/HO-1 pathway and inhibiting Cuproptosis.
Ding S, Hu D, Pan Y, Wang J, Wang L
Scientific reports 2025 Dec 19;15(1):44186
Scientific reports 2025 Dec 19;15(1):44186
MTF1 attenuates ferroptosis and cuproptosis synergistic potentiation in gastric cancer.
Luan M, Zhu W, Feng Z, Jing F, Xing Y, Ma X, Wang Y, Ning B, Jia Y
Cell death and differentiation 2025 Dec 19;
Cell death and differentiation 2025 Dec 19;
Melanoma MHC-I-membrane-encapsulated Cu@ferrihydrite induces ferroptosis/cuproptosis and systematic immunity against tumor.
Yang R, Deng F, Gao Z, Li X, Huangfu S, Tian Q, Wang H, Liu H, Wang X, Chen Y, Yang Y, Cheng G, Zhang L
Journal of controlled release : official journal of the Controlled Release Society 2025 Dec 10;388(Pt 1):114281
Journal of controlled release : official journal of the Controlled Release Society 2025 Dec 10;388(Pt 1):114281
An Activatable Dual-Engine Metabolic Inhibition Switch: Sequential Blockade of Glycolysis and Mitochondrial Respiration Potentiates Photodynamic Therapy via Tumor Reoxygenation.
Liu X, Sikong Y, Sun Y, Li J, Li R, Yang Z
ACS applied materials & interfaces 2025 Dec 10;17(49):66407-66418
ACS applied materials & interfaces 2025 Dec 10;17(49):66407-66418
Immunogenic cuproptosis in cancer immunotherapy via an in situ cuproptosis-inducing system.
Li J, Zhang G, Sun Z, Jiang M, Jia G, Liu H, Liu N, Shi L, Zhang L, Nie L, Zhang Y, Fu Y
Biomaterials 2025 Aug;319:123201
Biomaterials 2025 Aug;319:123201
High-Efficiency Carriers' Separation Strategy Based Ultrasmall-Bandgap CuWO(4) Sono-Enhances GSH Antagonism for Cuproptosis Cascade Immunotherapy.
Zhu L, Guo Z, Luo Y, Huang H, Zhang K, Duan B, Peng R, Yao H, Liang C, Wang K
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(29):e00576
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(29):e00576
Copper-Induced Cuproptosis and Immunogenic Cell Death Synergize with Radiotherapy and PD-1 Blockade in Osteosarcoma.
Yao J, Chen P, Xie D, Chen J, Lin X, Xu Y
ACS applied materials & interfaces 2025 Aug 20;17(33):46635-46650
ACS applied materials & interfaces 2025 Aug 20;17(33):46635-46650
Triphenylphosphine-Chitosan Functionalized MoS(2) Nanosheets Delivering Elesclomol-Cu(II) Complex for Enhanced Cuproptosis-Mediated Cancer Therapy.
Xu S, Chen Z, Huang Y, Zhong Y, Chen W
Biomacromolecules 2025 Aug 11;26(8):5438-5449
Biomacromolecules 2025 Aug 11;26(8):5438-5449
Responsive plasmonic hybrid nanorods enables metabolism reprogramming via cuproptosis-photothermal combined cancer therapy.
Xie Q, Sun T, Zhang L, Gong M, Zhang W, Liu X, Zhao Y, Wang M, Yang X, Zhang Z, Liu G, Zhou C, Zhang D
Biomaterials 2025 Apr;315:122971
Biomaterials 2025 Apr;315:122971
Engineering M2 macrophage-derived exosomes modulate activated T cell cuproptosis to promote immune tolerance in rheumatoid arthritis.
Wu G, Su T, Zhou P, Tang R, Zhu X, Wang J, Chao M, Fan L, Yan H, Ye P, Yu D, Gao F, Chen H
Biomaterials 2025 Apr;315:122943
Biomaterials 2025 Apr;315:122943
Multifunctional porous organic polymer-based hybrid nanoparticles for sonodynamically enhanced cuproptosis and synergistic tumor therapy.
Li M, Liu Z, Peng D, Liu Y, Cheng L, Chen B, Liu J
Acta biomaterialia 2025 Apr;196:350-363
Acta biomaterialia 2025 Apr;196:350-363
Engineering Dual-Responsive Nanoplatform Achieves Copper Metabolism Disruption and Glutathione Consumption to Provoke Cuproptosis/Ferroptosis/Apoptosis for Cancer Therapy.
Zhang M, Xu H, Wu X, Chen B, Gong X, He Y
ACS applied materials & interfaces 2025 Apr 9;17(14):20726-20740
ACS applied materials & interfaces 2025 Apr 9;17(14):20726-20740
Chlorophyllin exerts synergistic anti-tumor effect with gemcitabine in pancreatic cancer by inducing cuproptosis.
Ren J, Su T, Ding J, Chen F, Mo J, Li J, Wang Z, Han L, Wu Z, Wu S
Molecular medicine (Cambridge, Mass.) 2025 Apr 4;31(1):126
Molecular medicine (Cambridge, Mass.) 2025 Apr 4;31(1):126
Impact of diabetes and metformin on cuproptosis and ferroptosis in breast cancer patients: an immunohistochemical analysis.
Li C, Chen T, Li Y, Zhou C, Du J, Li X, Tang C, Ma C, Deng N, Cui H
Discover oncology 2025 Apr 29;16(1):634
Discover oncology 2025 Apr 29;16(1):634
Copper-mediated SEC14L3 promotes cuproptosis to inhibit hepatocellular carcinoma growth via ERK/YY1/FDX1 axis.
Wu C, Long L, Wang M, Shen L, Hu J, Tang H, Feng S, Liu X, Shi Y, Tang S, Chen Y
Communications biology 2025 Apr 24;8(1):658
Communications biology 2025 Apr 24;8(1):658
Serum DLAT Is a Potential Diagnostic Marker in AFP-Negative HCC.
Huang F, Bai J, Hu L, Luo C, Ning L
Biological & pharmaceutical bulletin 2024;47(12):2127-2137
Biological & pharmaceutical bulletin 2024;47(12):2127-2137
Exploring prognosis and therapeutic strategies for HBV-HCC patients based on disulfidptosis-related genes.
Zhang C, Zhang X, Dai S, Yang W
Frontiers in genetics 2024;15:1522484
Frontiers in genetics 2024;15:1522484
Cuproptosis-related lncRNAs emerge as a novel signature for predicting prognosis in prostate carcinoma and functional experimental validation.
Lu Y, Wu J, Li X, Leng Q, Tan J, Huang H, Zhong R, Chen Z, Zhang Y
Frontiers in immunology 2024;15:1471198
Frontiers in immunology 2024;15:1471198
GSH exhaustion via inhibition of xCT-GSH-GPX4 pathway synergistically enhanced DSF/Cu-induced cuproptosis in myelodysplastic syndromes.
Li H, Li Y, Yu Y, Ren X, Yang C, Jin W, Li K, Zhou Y, Wu C, Shen Y, Hu W, Liu Y, Yu L, Tong X, Du J, Wang Y
Free radical biology & medicine 2024 Sep;222:130-148
Free radical biology & medicine 2024 Sep;222:130-148
Metal-Doping Strategy for Carbon-Based Sonosensitizer in Sonodynamic Therapy of Glioblastoma.
Cheng M, Liu Y, You Q, Lei Z, Ji J, Zhang F, Dong WF, Li L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Sep;11(34):e2404230
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Sep;11(34):e2404230
Identification of diagnostic signature and immune infiltration for ischemic cardiomyopathy based on cuproptosis-related genes through bioinformatics analysis and experimental validation.
Tan X, Xu S, Zeng Y, Qin Z, Yu F, Jiang H, Xu H, Li X, Wang X, Zhang G, Ma B, Zhang T, Fan J, Bo X, Kang P, Tang J, Fan H, Zhou Y
International immunopharmacology 2024 Sep 10;138:112574
International immunopharmacology 2024 Sep 10;138:112574
Novel Insights Into DLAT's Role in Alzheimer's Disease-Related Copper Toxicity Through Microglial Exosome Dynamics.
Ma X, Sun Y, Li C, Wang M, Zang Q, Zhang X, Wang F, Niu Y, Hua J
CNS neuroscience & therapeutics 2024 Oct;30(10):e70064
CNS neuroscience & therapeutics 2024 Oct;30(10):e70064
CuO Nanozymes Catalyze Cysteine and Glutathione Depletion Induced Ferroptosis and Cuproptosis for Synergistic Tumor Therapy.
Bai J, Zhang X, Zhao Z, Sun S, Cheng W, Yu H, Chang X, Wang B
Small (Weinheim an der Bergstrasse, Germany) 2024 Oct;20(40):e2400326
Small (Weinheim an der Bergstrasse, Germany) 2024 Oct;20(40):e2400326
Three Birds with One Stone: Copper Ions Assisted Synergistic Cuproptosis/Chemodynamic/Photothermal Therapy by a Three-Pronged Approach.
Chen M, Xu C, Wang C, Huang N, Bian Z, Xiao Y, Ruan J, Sun F, Shi S
Advanced healthcare materials 2024 Nov;13(29):e2401567
Advanced healthcare materials 2024 Nov;13(29):e2401567
Copper-Based Composites Nanoparticles Improve Triple-Negative Breast Cancer Treatment with Induction of Apoptosis-Cuproptosis and Immune Activation.
Wang N, Liu Y, Peng D, Zhang Q, Zhang Z, Xu L, Yin L, Zhao X, Lu Z, Peng J
Advanced healthcare materials 2024 Nov;13(28):e2401646
Advanced healthcare materials 2024 Nov;13(28):e2401646
Biomimetic Nano-Regulator that Induces Cuproptosis and Lactate-Depletion Mediated ROS Storm for Metalloimmunotherapy of Clear Cell Renal Cell Carcinoma.
Xu X, Li H, Tong B, Zhang W, Wang X, Wang Y, Tian G, Xu Z, Zhang G
Advanced healthcare materials 2024 Nov;13(28):e2400204
Advanced healthcare materials 2024 Nov;13(28):e2400204
Anti-mitochondrial antibodies in systemic sclerosis target enteric neurons and are associated with GI dysmotility.
McMahan ZH, Casciola-Rosen L, Kaniecki T, Gutierrez-Alamillo L, Ming SH, Seika P, Kulkarni S
medRxiv : the preprint server for health sciences 2024 Nov 30;
medRxiv : the preprint server for health sciences 2024 Nov 30;
Inhalable metal-organic framework-mediated cuproptosis combined with PD-L1 checkpoint blockade for lung metastasis synergistic immunotherapy.
Yan C, Liu Y, Zhao G, Yang H, Lv H, Li G, Li Y, Fu Y, Sun F, Feng Y, Li Y, Zhao Z
Acta pharmaceutica Sinica. B 2024 May;14(5):2281-2297
Acta pharmaceutica Sinica. B 2024 May;14(5):2281-2297
Comprehensive molecular analyses of cuproptosis-related genes with regard to prognosis, immune landscape, and response to immune checkpoint blockers in lung adenocarcinoma.
Li R, Tong R, Zhang JL, Zhang Z, Deng M, Hou G
Journal of cancer research and clinical oncology 2024 May 9;150(5):246
Journal of cancer research and clinical oncology 2024 May 9;150(5):246
Prognostic value and immunological function of cuproptosis-related genes in lung adenocarcinoma.
Zhang L, Wang S, Wang L
Heliyon 2024 May 15;10(9):e30446
Heliyon 2024 May 15;10(9):e30446
Retinoic acid mitigates the NSC319726-induced spermatogenesis dysfunction through cuproptosis-independent mechanisms.
Yi H, Chen T, He G, Liu L, Zhao J, Guo K, Cao Y, Sun P, Zhou X, Zhang B, Li C, Wang H
Cell biology and toxicology 2024 May 1;40(1):26
Cell biology and toxicology 2024 May 1;40(1):26
Decreased pyruvate dehydrogenase activity in Tafazzin-deficient cells is caused by dysregulation of pyruvate dehydrogenase phosphatase 1 (PDP1).
Liang Z, Ralph-Epps T, Schmidtke MW, Kumar V, Greenberg ML
The Journal of biological chemistry 2024 Mar;300(3):105697
The Journal of biological chemistry 2024 Mar;300(3):105697
Precision targeting of CuET overload to disrupt mitochondrial unfolded protein response by integrated liposome.
Yin X, Wu B, Yang Y, Shi J, Fu Y, Zhang H, Ye J, Sun Y, Chen C, Zhu Y, Zhang W
International journal of biological macromolecules 2024 Mar;262(Pt 1):129974
International journal of biological macromolecules 2024 Mar;262(Pt 1):129974
Acetyl-CoA production by Mediator-bound 2-ketoacid dehydrogenases boosts de novo histone acetylation and is regulated by nitric oxide.
Russo M, Gualdrini F, Vallelonga V, Prosperini E, Noberini R, Pedretti S, Borriero C, Di Chiaro P, Polletti S, Imperato G, Marenda M, Ghirardi C, Bedin F, Cuomo A, Rodighiero S, Bonaldi T, Mitro N, Ghisletti S, Natoli G
Molecular cell 2024 Mar 7;84(5):967-980.e10
Molecular cell 2024 Mar 7;84(5):967-980.e10
MUC20 regulated by extrachromosomal circular DNA attenuates proteasome inhibitor resistance of multiple myeloma by modulating cuproptosis.
Wang X, Shi Y, Shi H, Liu X, Liao A, Liu Z, Orlowski RZ, Zhang R, Wang H
Journal of experimental & clinical cancer research : CR 2024 Mar 5;43(1):68
Journal of experimental & clinical cancer research : CR 2024 Mar 5;43(1):68
A cuproptosis-related gene expression signature predicting clinical prognosis and immune responses in intrahepatic cholangiocarcinoma detected by single-cell RNA sequence analysis.
Ren H, Liu C, Zhang C, Wu H, Zhang J, Wang Z, Chen L, Wang H, Shao C, Zhou L
Cancer cell international 2024 Mar 2;24(1):92
Cancer cell international 2024 Mar 2;24(1):92
Integrated analysis identifies cuproptosis-related gene DLAT and its competing endogenous RNAs network to predict the prognosis of pancreatic adenocarcinoma patients.
Zhou C, Jin L, Yu J, Gao Z
Medicine 2024 Mar 1;103(9):e37322
Medicine 2024 Mar 1;103(9):e37322
Clinical features and molecular landscape of cuproptosis signature-related molecular subtype in gastric cancer.
Chong W, Ren H, Chen H, Xu K, Zhu X, Liu Y, Sang Y, Li H, Liu J, Ye C, Shang L, Jing C, Li L
iMeta 2024 Jun;3(3):e190
iMeta 2024 Jun;3(3):e190
Elesclomol-copper synergizes with imidazole ketone erastin by promoting cuproptosis and ferroptosis in myelodysplastic syndromes.
Gao Y, Jin F, Zhang P, Zheng C, Zheng X, Xie J, Lu Y, Tong X, Du J, Zhang J, Wang Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jun;175:116727
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jun;175:116727
Combating Atherosclerosis with Chirality/Phase Dual-Engineered Nanozyme Featuring Microenvironment-Programmed Senolytic and Senomorphic Actions.
Ding C, Min J, Tan Y, Zheng L, Ma R, Zhao R, Zhao H, Ding Q, Chen H, Huo D
Advanced materials (Deerfield Beach, Fla.) 2024 Jul;36(29):e2401361
Advanced materials (Deerfield Beach, Fla.) 2024 Jul;36(29):e2401361
Mitochondrial-Targeted Copper Delivery for Cuproptosis-Based Synergistic Cancer Therapy.
Deng J, Zhuang H, Shao S, Zeng X, Xue P, Bai T, Wang X, Shangguan S, Chen Y, Yan S, Huang W
Advanced healthcare materials 2024 Jul;13(18):e2304522
Advanced healthcare materials 2024 Jul;13(18):e2304522
Molecular characterization and clinical relevance of metabolic signature subtypes in gastric cancer.
Chen H, Jing C, Shang L, Zhu X, Zhang R, Liu Y, Wang M, Xu K, Ma T, Jing H, Wang Z, Li X, Chong W, Li L
Cell reports 2024 Jul 23;43(7):114424
Cell reports 2024 Jul 23;43(7):114424
Biomarker Identification and Risk Prediction Model Development for Differentiated Thyroid Carcinoma Lung Metastasis Based on Primary Lesion Proteomics.
Peng X, Zhao H, Ye L, Hou F, Yi Z, Ren Y, Lu L, Chen F, Lv J, Wang Y, Cai H, Zheng X, Yang Q, Chen T
Clinical cancer research : an official journal of the American Association for Cancer Research 2024 Jul 15;30(14):3059-3072
Clinical cancer research : an official journal of the American Association for Cancer Research 2024 Jul 15;30(14):3059-3072
Hypoxia induces mitochondrial protein lactylation to limit oxidative phosphorylation.
Mao Y, Zhang J, Zhou Q, He X, Zheng Z, Wei Y, Zhou K, Lin Y, Yu H, Zhang H, Zhou Y, Lin P, Wu B, Yuan Y, Zhao J, Xu W, Zhao S
Cell research 2024 Jan;34(1):13-30
Cell research 2024 Jan;34(1):13-30
Identification of cuproptosis-related molecular classification and characteristic genes in ulcerative colitis.
Bai X, Zhang F, Zhou C, Yan J, Liang H, Zhu R, Gong M, Song H, Niu J, Miao Y
Heliyon 2024 Jan 30;10(2):e24875
Heliyon 2024 Jan 30;10(2):e24875
Engineered Microbial Nanohybrids for Tumor-Mediated NIR II Photothermal Enhanced Ferroptosis/Cuproptosis and Immunotherapy.
Ruan Y, Zhuang H, Zeng X, Lin L, Wang X, Xue P, Xu S, Chen Q, Yan S, Huang W
Advanced healthcare materials 2024 Feb;13(4):e2302537
Advanced healthcare materials 2024 Feb;13(4):e2302537
Sirtuin 7 ameliorates cuproptosis, myocardial remodeling and heart dysfunction in hypertension through the modulation of YAP/ATP7A signaling.
Chen YF, Qi RQ, Song JW, Wang SY, Dong ZJ, Chen YH, Liu Y, Zhou XY, Li J, Liu XY, Zhong JC
Apoptosis : an international journal on programmed cell death 2024 Dec;29(11-12):2161-2182
Apoptosis : an international journal on programmed cell death 2024 Dec;29(11-12):2161-2182
Tumor Microenvironment Reprogrammed Bimetallic Hybrid Nanostimulator for Triggering Radio-Cuproptosis-Immunotherapy.
Jiang X, Wang J, Huang W, Ma H, Zhang S, Cai Z, Lin W, Zheng J
Advanced healthcare materials 2024 Dec;13(30):e2401902
Advanced healthcare materials 2024 Dec;13(30):e2401902
Synergistic enhancement of low-dose radiation therapy via cuproptosis and metabolic reprogramming for radiosensitization in in situ hepatocellular carcinoma.
Shao N, Yang Y, Hu G, Luo Q, Cheng N, Chen J, Huang Y, Zhang H, Luo L, Xiao Z
Journal of nanobiotechnology 2024 Dec 19;22(1):772
Journal of nanobiotechnology 2024 Dec 19;22(1):772
Metabolic shifts in lipid utilization and reciprocal interactions within the lung metastatic niche of triple-negative breast cancer revealed by spatial multi-omics.
Kan JY, Lee HC, Hou MF, Tsai HP, Jian SF, Chang CY, Tsai PH, Lin YS, Tsai YM, Wu KL, Huang YC, Hsu YL
Cell death & disease 2024 Dec 18;15(12):899
Cell death & disease 2024 Dec 18;15(12):899
Optimization of protocols for immunohistochemical assessment of enteric nervous system in formalin fixed human tissue.
Hong SM, Qian X, Deshpande V, Kulkarni S
bioRxiv : the preprint server for biology 2024 Dec 17;
bioRxiv : the preprint server for biology 2024 Dec 17;
TRIM24-DTNBP1-ATP7A mediated astrocyte cuproptosis in cognition and memory dysfunction caused by Y(2)O(3) NPs.
Chen Z, Liu J, Zheng M, Mo M, Hu X, Liu C, Pathak JL, Wang L, Chen L
The Science of the total environment 2024 Dec 1;954:176353
The Science of the total environment 2024 Dec 1;954:176353
Inhalable nanoparticles with enhanced cuproptosis and cGAS-STING activation for synergistic lung metastasis immunotherapy.
Yan C, Lv H, Feng Y, Li Y, Zhao Z
Acta pharmaceutica Sinica. B 2024 Aug;14(8):3697-3710
Acta pharmaceutica Sinica. B 2024 Aug;14(8):3697-3710
Helicobacter Pylori-Enhanced hnRNPA2B1 Coordinates with PABPC1 to Promote Non-m(6)A Translation and Gastric Cancer Progression.
Yu Y, Yang YL, Chen XY, Chen ZY, Zhu JS, Zhang J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(30):e2309712
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(30):e2309712
Mitochondrial copper overload promotes renal fibrosis via inhibiting pyruvate dehydrogenase activity.
Zhu S, Niu Y, Zhou W, Liu Y, Liu J, Liu X, Lu L, Yu C
Cellular and molecular life sciences : CMLS 2024 Aug 9;81(1):340
Cellular and molecular life sciences : CMLS 2024 Aug 9;81(1):340
A singular plasmonic-thermoelectric hollow nanostructure inducing apoptosis and cuproptosis for catalytic cancer therapy.
Yang L, Zhao Z, Tian B, Yang M, Dong Y, Zhou B, Gai S, Xie Y, Lin J
Nature communications 2024 Aug 29;15(1):7499
Nature communications 2024 Aug 29;15(1):7499
Injectable Hydrogel-Encapsulating Pickering Emulsion for Overcoming Lenvatinib-Resistant Hepatocellular Carcinoma via Cuproptosis Induction and Stemness Inhibition.
Li X, Tang C, Ye H, Fang C
Polymers 2024 Aug 26;16(17)
Polymers 2024 Aug 26;16(17)
Cuproptosis associated cytoskeletal destruction contributes to podocyte injury in chronic kidney disease.
Li H, Fu Y, Xu Y, Miao H, Wang H, Zhang T, Mei X, He Y, Zhang A, Ge X
American journal of physiology. Cell physiology 2024 Aug 1;327(2):C254-C269
American journal of physiology. Cell physiology 2024 Aug 1;327(2):C254-C269
Monocarboxylate transporter 4 deficiency enhances high-intensity interval training-induced metabolic adaptations in skeletal muscle.
Tamura Y, Jee E, Kouzaki K, Kotani T, Nakazato K
The Journal of physiology 2024 Apr;602(7):1313-1340
The Journal of physiology 2024 Apr;602(7):1313-1340
Demystifying the landscape of endometrial immune microenvironment in luteal-phase from cuprotosis: Implications for the mechanism and treatment of RPL.
Zhao X, Wang S, Du T, Jiang Y, Zhao Y, Ma Y, Shen D, Shen Y, Ma J
Gene 2024 Apr 20;903:148191
Gene 2024 Apr 20;903:148191
Cellular Trojan Horse initiates bimetallic Fe-Cu MOF-mediated synergistic cuproptosis and ferroptosis against malignancies.
Chen K, Zhou A, Zhou X, He J, Xu Y, Ning X
Science advances 2024 Apr 12;10(15):eadk3201
Science advances 2024 Apr 12;10(15):eadk3201
A Y374X TDP43 truncation leads to an altered metabolic profile in amyotrophic lateral sclerosis fibroblasts driven by pyruvate and TCA cycle intermediate alterations.
Allen SP, Al Sultan A, Kabucho Kibirige E, Tonkiss E, Hamer KJ, Castelli LM, Lin YH, Roscoe S, Stefanidis N, Mead RJ, Highley JR, Cooper-Knock J, Hautbergue GM, Heath PR, Kirby J, Shaw PJ
Frontiers in aging neuroscience 2023;15:1151848
Frontiers in aging neuroscience 2023;15:1151848
Prediction of prognosis, immune infiltration, and personalized treatment of hepatocellular carcinoma by analysis of cuproptosis-related long noncoding RNAs and verification in vitro.
Li S, Zhu Z, Lu J, Cao W, Song F, Xiao C, Zhang P, He Z, Weng J, Xu J
Frontiers in oncology 2023;13:1159126
Frontiers in oncology 2023;13:1159126
ITGB1-mediated molecular landscape and cuproptosis phenotype induced the worse prognosis in diffuse gastric cancer.
Zhu X, Chen H, Li H, Ren H, Ye C, Xu K, Liu J, Du F, Zhang Z, Liu Y, Xie X, Wang M, Ma T, Chong W, Shang L, Li L
Frontiers in oncology 2023;13:1115510
Frontiers in oncology 2023;13:1115510
Cuproptosis enhances docetaxel chemosensitivity by inhibiting autophagy via the DLAT/mTOR pathway in prostate cancer.
Wen H, Qu C, Wang Z, Gao H, Liu W, Wang H, Sun H, Gu J, Yang Z, Wang X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Sep;37(9):e23145
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Sep;37(9):e23145
DLAT is a promising prognostic marker and therapeutic target for hepatocellular carcinoma: a comprehensive study based on public databases.
Zhang P, Zhao JH, Yuan LX, Ju LL, Wang HX, Wang F, Chen L, Cai WH
Scientific reports 2023 Oct 12;13(1):17295
Scientific reports 2023 Oct 12;13(1):17295
Identification of a novel cuproptosis-related gene signature for rheumatoid arthritis-A prospective study.
Hu H, Dou X, Hu X, Wang L, Ma Y, Liu J, Zhou X, Cao H, Liu X, Deng X, Li N
The journal of gene medicine 2023 Nov;25(11):e3535
The journal of gene medicine 2023 Nov;25(11):e3535
Cuproptosis-related gene DLAT serves as a prognostic biomarker for immunotherapy in clear cell renal cell carcinoma: multi-database and experimental verification.
Huang S, Cai C, Zhou K, Wang X, Wang X, Cen D, Weng G
Aging 2023 Nov 7;15(21):12314-12329
Aging 2023 Nov 7;15(21):12314-12329
Cuproptosis-Related Gene DLAT as a Novel Biomarker Correlated with Prognosis, Chemoresistance, and Immune Infiltration in Pancreatic Adenocarcinoma: A Preliminary Study Based on Bioinformatics Analysis.
Fang Z, Wang W, Liu Y, Hua J, Liang C, Liu J, Zhang B, Shi S, Yu X, Meng Q, Xu J
Current oncology (Toronto, Ont.) 2023 Mar 2;30(3):2997-3019
Current oncology (Toronto, Ont.) 2023 Mar 2;30(3):2997-3019
DLAT as a Cuproptosis Promoter and a Molecular Target of Elesclomol in Hepatocellular Carcinoma.
Gao F, Yuan Y, Ding Y, Li PY, Chang Y, He XX
Current medical science 2023 Jun;43(3):526-538
Current medical science 2023 Jun;43(3):526-538
Comprehensive analysis identifies cuproptosis-related gene DLAT as a potential prognostic and immunological biomarker in pancreatic adenocarcinoma.
Zhang X, Zhou Y, Hu J, Yu X, Xu H, Ba Z, Zhang H, Sun Y, Wang R, Du X, Mou R, Li X, Zhu J, Xie R
BMC cancer 2023 Jun 17;23(1):560
BMC cancer 2023 Jun 17;23(1):560
Molecular subtypes based on cuproptosis-related genes and tumor microenvironment infiltration characteristics in pancreatic adenocarcinoma.
Li J, Yin J, Li W, Wang H, Ni B
Cancer cell international 2023 Jan 16;23(1):7
Cancer cell international 2023 Jan 16;23(1):7
Tetrathiomolybdate Decreases the Expression of Alkaline Phosphatase in Dermal Papilla Cells by Increasing Mitochondrial ROS Production.
Li F, Liu H, Wu X, Song Z, Tang H, Gong M, Liu L, Li F
International journal of molecular sciences 2023 Feb 4;24(4)
International journal of molecular sciences 2023 Feb 4;24(4)
Cuproptosis-related molecular patterns and gene (ATP7A) in hepatocellular carcinoma and their relationships with tumor immune microenvironment and clinical features.
Li S, Weng J, Xiao C, Lu J, Cao W, Song F, He Z, Zhang P, Zhu Z, Xu J
Cancer reports (Hoboken, N.J.) 2023 Dec;6(12):e1904
Cancer reports (Hoboken, N.J.) 2023 Dec;6(12):e1904
Dexmedetomidine enables copper homeostasis in cerebral ischemia/reperfusion via ferredoxin 1.
Guo Q, Ma M, Yu H, Han Y, Zhang D
Annals of medicine 2023 Dec;55(1):2209735
Annals of medicine 2023 Dec;55(1):2209735
A novel signature to guide osteosarcoma prognosis and immune microenvironment: Cuproptosis-related lncRNA.
Yang M, Zheng H, Xu K, Yuan Q, Aihaiti Y, Cai Y, Xu P
Frontiers in immunology 2022;13:919231
Frontiers in immunology 2022;13:919231
Comprehensive analysis of cuproptosis-related genes in immune infiltration and diagnosis in ulcerative colitis.
Huang J, Zhang J, Wang F, Zhang B, Tang X
Frontiers in immunology 2022;13:1008146
Frontiers in immunology 2022;13:1008146
Establishment and experimental validation of a novel cuproptosis-related gene signature for prognostic implication in cholangiocarcinoma.
Chen J, Yu X, Tong H, Tang C, Tang Z
Frontiers in oncology 2022;12:1054063
Frontiers in oncology 2022;12:1054063
Beneficial effects of aloperine on inflammation and oxidative stress by suppressing necroptosis in lipopolysaccharide-induced acute lung injury mouse model.
Cui YR, Qu F, Zhong WJ, Yang HH, Zeng J, Huang JH, Liu J, Zhang MY, Zhou Y, Guan CX
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jun;100:154074
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jun;100:154074
A new thinking: deciphering the aberrance and clinical implication of copper-death signatures in clear cell renal cell carcinoma.
Jiang A, Luo P, Chen M, Fang Y, Liu B, Wu Z, Qu L, Wang A, Wang L, Cai C
Cell & bioscience 2022 Dec 29;12(1):209
Cell & bioscience 2022 Dec 29;12(1):209
Luteolin Improves Cyclophosphamide-Induced Cystitis through TXNIP/NLRP3 and NF-κB Pathways.
Zhang H, Zhao J, Lu Q, Sun B, Liu X, Yang C, Li S, Li L, Yi S, Yang Z, Xu J
Evidence-based complementary and alternative medicine : eCAM 2021;2021:1718709
Evidence-based complementary and alternative medicine : eCAM 2021;2021:1718709
Potential hazardous effects of printing room PM2.5 exposure include promotion of lung inflammation and subsequent injury.
Zou C, Yang H, Cui L, Cao X, Huang H, Chen T
Molecular medicine reports 2020 Oct;22(4):3213-3224
Molecular medicine reports 2020 Oct;22(4):3213-3224
RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis.
Yang Z, Wang Y, Zhang Y, He X, Zhong CQ, Ni H, Chen X, Liang Y, Wu J, Zhao S, Zhou D, Han J
Nature cell biology 2018 Feb;20(2):186-197
Nature cell biology 2018 Feb;20(2):186-197
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The DLAT antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human DLAT. This antibody recognizes human,mouse,rat antigen. The DLAT antibody has been validated for the following applications: ELISA, WB analysis.
