13426-1-AP

antibody from Proteintech Group

Targeting: DLAT DLTA, E2, PDC-E2

Provider product page for 13426-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Antibody data

Antibody Data
Antigen structure
References [38]
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Validations
Western blot [1]

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Product number: 13426-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#13426-1-AP, RRID:AB_2091774
Product name: DLAT antibody
Antibody type: Polyclonal
Description: DLAT antibody (Cat. #13426-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

DLAT protein structure - 13426-1-AP shown in red.

Submitted references GSH exhaustion via inhibition of xCT-GSH-GPX4 pathway synergistically enhanced DSF/Cu-induced cuproptosis in myelodysplastic syndromes.

Li H, Li Y, Yu Y, Ren X, Yang C, Jin W, Li K, Zhou Y, Wu C, Shen Y, Hu W, Liu Y, Yu L, Tong X, Du J, Wang Y
Free radical biology & medicine 2024 Sep;222:130-148

Prognostic value and immunological function of cuproptosis-related genes in lung adenocarcinoma.

Zhang L, Wang S, Wang L
Heliyon 2024 May 15;10(9):e30446

Retinoic acid mitigates the NSC319726-induced spermatogenesis dysfunction through cuproptosis-independent mechanisms.

Yi H, Chen T, He G, Liu L, Zhao J, Guo K, Cao Y, Sun P, Zhou X, Zhang B, Li C, Wang H
Cell biology and toxicology 2024 May 1;40(1):26

Decreased pyruvate dehydrogenase activity in Tafazzin-deficient cells is caused by dysregulation of pyruvate dehydrogenase phosphatase 1 (PDP1).

Liang Z, Ralph-Epps T, Schmidtke MW, Kumar V, Greenberg ML
The Journal of biological chemistry 2024 Mar;300(3):105697

Precision targeting of CuET overload to disrupt mitochondrial unfolded protein response by integrated liposome.

Yin X, Wu B, Yang Y, Shi J, Fu Y, Zhang H, Ye J, Sun Y, Chen C, Zhu Y, Zhang W
International journal of biological macromolecules 2024 Mar;262(Pt 1):129974

Acetyl-CoA production by Mediator-bound 2-ketoacid dehydrogenases boosts de novo histone acetylation and is regulated by nitric oxide.

Russo M, Gualdrini F, Vallelonga V, Prosperini E, Noberini R, Pedretti S, Borriero C, Di Chiaro P, Polletti S, Imperato G, Marenda M, Ghirardi C, Bedin F, Cuomo A, Rodighiero S, Bonaldi T, Mitro N, Ghisletti S, Natoli G
Molecular cell 2024 Mar 7;84(5):967-980.e10

MUC20 regulated by extrachromosomal circular DNA attenuates proteasome inhibitor resistance of multiple myeloma by modulating cuproptosis.

Wang X, Shi Y, Shi H, Liu X, Liao A, Liu Z, Orlowski RZ, Zhang R, Wang H
Journal of experimental & clinical cancer research : CR 2024 Mar 5;43(1):68

A cuproptosis-related gene expression signature predicting clinical prognosis and immune responses in intrahepatic cholangiocarcinoma detected by single-cell RNA sequence analysis.

Ren H, Liu C, Zhang C, Wu H, Zhang J, Wang Z, Chen L, Wang H, Shao C, Zhou L
Cancer cell international 2024 Mar 2;24(1):92

Integrated analysis identifies cuproptosis-related gene DLAT and its competing endogenous RNAs network to predict the prognosis of pancreatic adenocarcinoma patients.

Zhou C, Jin L, Yu J, Gao Z
Medicine 2024 Mar 1;103(9):e37322

Clinical features and molecular landscape of cuproptosis signature-related molecular subtype in gastric cancer.

Chong W, Ren H, Chen H, Xu K, Zhu X, Liu Y, Sang Y, Li H, Liu J, Ye C, Shang L, Jing C, Li L
iMeta 2024 Jun;3(3):e190

Elesclomol-copper synergizes with imidazole ketone erastin by promoting cuproptosis and ferroptosis in myelodysplastic syndromes.

Gao Y, Jin F, Zhang P, Zheng C, Zheng X, Xie J, Lu Y, Tong X, Du J, Zhang J, Wang Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jun;175:116727

Combating Atherosclerosis with Chirality/Phase Dual-Engineered Nanozyme Featuring Microenvironment-Programmed Senolytic and Senomorphic Actions.

Ding C, Min J, Tan Y, Zheng L, Ma R, Zhao R, Zhao H, Ding Q, Chen H, Huo D
Advanced materials (Deerfield Beach, Fla.) 2024 Jul;36(29):e2401361

Mitochondrial-Targeted Copper Delivery for Cuproptosis-Based Synergistic Cancer Therapy.

Deng J, Zhuang H, Shao S, Zeng X, Xue P, Bai T, Wang X, Shangguan S, Chen Y, Yan S, Huang W
Advanced healthcare materials 2024 Jul;13(18):e2304522

Biomarker Identification and Risk Prediction Model Development for Differentiated Thyroid Carcinoma Lung Metastasis Based on Primary Lesion Proteomics.

Peng X, Zhao H, Ye L, Hou F, Yi Z, Ren Y, Lu L, Chen F, Lv J, Wang Y, Cai H, Zheng X, Yang Q, Chen T
Clinical cancer research : an official journal of the American Association for Cancer Research 2024 Jul 15;30(14):3059-3072

Hypoxia induces mitochondrial protein lactylation to limit oxidative phosphorylation.

Mao Y, Zhang J, Zhou Q, He X, Zheng Z, Wei Y, Zhou K, Lin Y, Yu H, Zhang H, Zhou Y, Lin P, Wu B, Yuan Y, Zhao J, Xu W, Zhao S
Cell research 2024 Jan;34(1):13-30

Engineered Microbial Nanohybrids for Tumor-Mediated NIR II Photothermal Enhanced Ferroptosis/Cuproptosis and Immunotherapy.

Ruan Y, Zhuang H, Zeng X, Lin L, Wang X, Xue P, Xu S, Chen Q, Yan S, Huang W
Advanced healthcare materials 2024 Feb;13(4):e2302537

Monocarboxylate transporter 4 deficiency enhances high-intensity interval training-induced metabolic adaptations in skeletal muscle.

Tamura Y, Jee E, Kouzaki K, Kotani T, Nakazato K
The Journal of physiology 2024 Apr;602(7):1313-1340

Cellular Trojan Horse initiates bimetallic Fe-Cu MOF-mediated synergistic cuproptosis and ferroptosis against malignancies.

Chen K, Zhou A, Zhou X, He J, Xu Y, Ning X
Science advances 2024 Apr 12;10(15):eadk3201

A Y374X TDP43 truncation leads to an altered metabolic profile in amyotrophic lateral sclerosis fibroblasts driven by pyruvate and TCA cycle intermediate alterations.

Allen SP, Al Sultan A, Kabucho Kibirige E, Tonkiss E, Hamer KJ, Castelli LM, Lin YH, Roscoe S, Stefanidis N, Mead RJ, Highley JR, Cooper-Knock J, Hautbergue GM, Heath PR, Kirby J, Shaw PJ
Frontiers in aging neuroscience 2023;15:1151848

ITGB1-mediated molecular landscape and cuproptosis phenotype induced the worse prognosis in diffuse gastric cancer.

Zhu X, Chen H, Li H, Ren H, Ye C, Xu K, Liu J, Du F, Zhang Z, Liu Y, Xie X, Wang M, Ma T, Chong W, Shang L, Li L
Frontiers in oncology 2023;13:1115510

Cuproptosis enhances docetaxel chemosensitivity by inhibiting autophagy via the DLAT/mTOR pathway in prostate cancer.

Wen H, Qu C, Wang Z, Gao H, Liu W, Wang H, Sun H, Gu J, Yang Z, Wang X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Sep;37(9):e23145

DLAT is a promising prognostic marker and therapeutic target for hepatocellular carcinoma: a comprehensive study based on public databases.

Zhang P, Zhao JH, Yuan LX, Ju LL, Wang HX, Wang F, Chen L, Cai WH
Scientific reports 2023 Oct 12;13(1):17295

Identification of a novel cuproptosis-related gene signature for rheumatoid arthritis-A prospective study.

Hu H, Dou X, Hu X, Wang L, Ma Y, Liu J, Zhou X, Cao H, Liu X, Deng X, Li N
The journal of gene medicine 2023 Nov;25(11):e3535

Huang S, Cai C, Zhou K, Wang X, Wang X, Cen D, Weng G
Aging 2023 Nov 7;15(21):12314-12329

Fang Z, Wang W, Liu Y, Hua J, Liang C, Liu J, Zhang B, Shi S, Yu X, Meng Q, Xu J
Current oncology (Toronto, Ont.) 2023 Mar 2;30(3):2997-3019

DLAT as a Cuproptosis Promoter and a Molecular Target of Elesclomol in Hepatocellular Carcinoma.

Gao F, Yuan Y, Ding Y, Li PY, Chang Y, He XX
Current medical science 2023 Jun;43(3):526-538

Comprehensive analysis identifies cuproptosis-related gene DLAT as a potential prognostic and immunological biomarker in pancreatic adenocarcinoma.

Zhang X, Zhou Y, Hu J, Yu X, Xu H, Ba Z, Zhang H, Sun Y, Wang R, Du X, Mou R, Li X, Zhu J, Xie R
BMC cancer 2023 Jun 17;23(1):560

Molecular subtypes based on cuproptosis-related genes and tumor microenvironment infiltration characteristics in pancreatic adenocarcinoma.

Li J, Yin J, Li W, Wang H, Ni B
Cancer cell international 2023 Jan 16;23(1):7

Tetrathiomolybdate Decreases the Expression of Alkaline Phosphatase in Dermal Papilla Cells by Increasing Mitochondrial ROS Production.

Li F, Liu H, Wu X, Song Z, Tang H, Gong M, Liu L, Li F
International journal of molecular sciences 2023 Feb 4;24(4)

Li S, Weng J, Xiao C, Lu J, Cao W, Song F, He Z, Zhang P, Zhu Z, Xu J
Cancer reports (Hoboken, N.J.) 2023 Dec;6(12):e1904

Dexmedetomidine enables copper homeostasis in cerebral ischemia/reperfusion via ferredoxin 1.

Guo Q, Ma M, Yu H, Han Y, Zhang D
Annals of medicine 2023 Dec;55(1):2209735

Comprehensive analysis of cuproptosis-related genes in immune infiltration and diagnosis in ulcerative colitis.

Huang J, Zhang J, Wang F, Zhang B, Tang X
Frontiers in immunology 2022;13:1008146

Establishment and experimental validation of a novel cuproptosis-related gene signature for prognostic implication in cholangiocarcinoma.

Chen J, Yu X, Tong H, Tang C, Tang Z
Frontiers in oncology 2022;12:1054063

Beneficial effects of aloperine on inflammation and oxidative stress by suppressing necroptosis in lipopolysaccharide-induced acute lung injury mouse model.

Cui YR, Qu F, Zhong WJ, Yang HH, Zeng J, Huang JH, Liu J, Zhang MY, Zhou Y, Guan CX
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jun;100:154074

A new thinking: deciphering the aberrance and clinical implication of copper-death signatures in clear cell renal cell carcinoma.

Jiang A, Luo P, Chen M, Fang Y, Liu B, Wu Z, Qu L, Wang A, Wang L, Cai C
Cell & bioscience 2022 Dec 29;12(1):209

Luteolin Improves Cyclophosphamide-Induced Cystitis through TXNIP/NLRP3 and NF-κB Pathways.

Zhang H, Zhao J, Lu Q, Sun B, Liu X, Yang C, Li S, Li L, Yi S, Yang Z, Xu J
Evidence-based complementary and alternative medicine : eCAM 2021;2021:1718709

Potential hazardous effects of printing room PM2.5 exposure include promotion of lung inflammation and subsequent injury.

Zou C, Yang H, Cui L, Cao X, Huang H, Chen T
Molecular medicine reports 2020 Oct;22(4):3213-3224

RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis.

Yang Z, Wang Y, Zhang Y, He X, Zhong CQ, Ni H, Chen X, Liang Y, Wu J, Zhao S, Zhou D, Han J
Nature cell biology 2018 Feb;20(2):186-197

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The DLAT antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human DLAT. This antibody recognizes human,mouse,rat antigen. The DLAT antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 13426-1-AP.pdf

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