Tissue expression
Cell line expression
Protein structure
DRAP1
DR1 associated protein 1NC2-alpha
Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans. Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly of a large multiprotein complex consisting of RNA polymerase II and general transcription factors such as TFIIA, TFIIB, and TFIID. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex. The protein encoded by this gene is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. The interaction between this corepressor and DR1 is required for corepressor function and appears to stabilize the TBP-DR1-DNA complex. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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NSJ Bioreagents | V4173 | Monoclonal |
ICC
IHC
FC
PA
OA
|
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Proteintech Group | 11020-1-AP | Polyclonal |
WB
EL
ICC
IHC |
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NovoPro Bioscience Inc. | 110014 | Polyclonal |
WB
EL
ICC
IHC |
||
Invitrogen Antibodies | 11020-1-AP | Polyclonal |
WB
ICC
IHC
|
||
Cusabio Biotech Co., Ltd | CSB-PA007177GA01HU | Polyclonal |
WB
EL
ICC
IHC |
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